Senior Faculty, Center for Women’s Health Research
(2020)
School of Medicine,
Pediatrics
NRP Instructor
(2003)
School of Medicine,
Pediatrics
Associate Professor of Pediatrics
(2007)
School of Medicine,
Pediatrics
Fetal growth, fetal programming, skeletal muscle metabolism, neonatal nutrition, neonatal resuscitation
Publications
Stremming J, White A, Donthi A, Batt DG, Hetrick B, Chang EI, Wesolowski SR, Seefeldt MB, McCurdy CE, Rozance PJ, Brown LD. Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep. Front Physiol. 2022;13:954948. PubMed PMID: 36091374
Hesse H, Palmer C, Rigdon CD, Galan HL, Hobbins JC, Brown LD. Differences in body composition and growth persist postnatally in fetuses diagnosed with severe compared to mild fetal growth restriction. J Neonatal Perinatal Med. 2022;15(3):589-598. PubMed PMID: 35342050
Jones AK, Wang D, Goldstrohm DA, Brown LD, Rozance PJ, Limesand SW, Wesolowski SR. Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep. Am J Physiol Endocrinol Metab. 2022 Feb 1;322(2):E181-E196. PubMed PMID: 34957858
Stremming J, Chang EI, Knaub LA, Armstrong ML, Baker PR 2nd, Wesolowski SR, Reisdorph N, Reusch JEB, Brown LD. Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth-restricted fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2022 Mar 1;322(3):R228-R240. PubMed PMID: 34907787
Brown LD, Palmer C, Teynor L, Boehmer BH, Stremming J, Chang EI, White A, Jones AK, Cilvik SN, Wesolowski SR, Rozance PJ. Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency. Reprod Sci. 2022 Jun;29(6):1776-1789. PubMed PMID: 34611848
Steller JG, Gumina D, Driver C, Palmer C, Brown LD, Reeves S, Hobbins JC, Galan HL. 3D Fractional Limb Volume Identifies Reduced Subcutaneous and Lean Mass in Fetal Growth Restriction. J Ultrasound Med. 2022 Jul;41(7):1623-1632. PubMed PMID: 34580892
Brown LD, Palmer C, Teynor L, Boehmer BH, Stremming J, Chang EI, White A, Jones AK, Cilvik SN, Wesolowski SR, Rozance PJ. Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency. Reprod Sci. 2021 Oct 5. [Epub ahead of print] PubMed PMID: 34611848
Steller JG, Gumina D, Driver C, Palmer C, Brown LD, Reeves S, Hobbins JC, Galan HL. 3D Fractional Limb Volume Identifies Reduced Subcutaneous and Lean Mass in Fetal Growth Restriction. J Ultrasound Med. 2021 Sep 28. [Epub ahead of print] PubMed PMID: 34580892
Jones AK, Rozance PJ, Brown LD, Lorca RA, Julian CG, Moore LG, Limesand SW, Wesolowski SR. Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. Physiol Rep. 2021 Sep;9(18):e15033. PubMed PMID: 34558219
Rozance PJ, Wesolowski SR, Jonker SS, Brown LD. Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2021 Sep 1;321(3):R352-R363. PubMed PMID: 34287074
White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ. Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab. 2021 Jun 1;320(6):E1138-E1147. PubMed PMID: 33938236
Cilvik SN, Wesolowski SR, Anthony RV, Brown LD, Rozance PJ. Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth. J Physiol. 2021 Jul;599(13):3403-3427. PubMed PMID: 33878802
Tang M, Weaver NE, Berman LM, Brown LD, Hendricks AE, Krebs NF. Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet. Nutrients. 2021 Jan 27;13(2). PubMed PMID: 33513734
Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 Apr;40:101827. PubMed PMID: 33485059
Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD. IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus. Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E527-E538. PubMed PMID: 33427051
Boehmer BH, Wesolowski SR, Brown LD, Rozance PJ. Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep. J Nutr. 2021 Feb 1;151(2):312-319. PubMed PMID: 33326574
Schinkel ER, Nelson ER, Young BE, Bernstein RM, Taylor SN, Brown LD, Hay WW Jr, Brown KJ, Prenni J. Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants. J Perinatol. 2021 Mar;41(3):582-589. PubMed PMID: 33060780
Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW Jr, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E721-E733. PubMed PMID: 32830555
Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ß Cells in Late-Gestation Sheep. J Nutr. 2020 Aug 1;150(8):2061-2069. PubMed PMID: 32470982
Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na(+) K(+) -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 Apr;598(8):1625-1639. PubMed PMID: 31909825
Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW Jr, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E721-E733. PubMed PMID: 32830555
Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ß Cells in Late-Gestation Sheep. J Nutr. 2020 Aug 1;150(8):2061-2069. PubMed PMID: 32470982
Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na( ) K( ) -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 Apr;598(8):1625-1639. PubMed PMID: 31909825
Schinkel ER, Nelson ER, Young BE, Bernstein RM, Taylor SN, Brown LD, Hay WW Jr, Brown KJ, Prenni J. Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants. J Perinatol. 2020 Oct 15. [Epub ahead of print] PubMed PMID: 33060780
Chang EI, Wesolowski SR, Gilje EA, Baker PR 2nd, Reisz JA, D'Alessandro A, Hay WW Jr, Rozance PJ, Brown LD. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth restricted fetal sheep hindlimb. Am J Physiol Regul Integr Comp Physiol. 2019 Sep 4. [Epub ahead of print] PubMed PMID: 31483682
Jones AK, Rozance PJ, Brown LD, Goldstrohm DA, Hay WW Jr, Limesand SW, Wesolowski SR. Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E1-E10. PubMed PMID: 30964701
Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW Jr, Friedman JE, Wesolowski SR. Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R427-R440. PubMed PMID: 30758974
Chang EI, Rozance PJ, Wesolowski SR, Nguyen LM, Shaw SC, Sclafani RA, Bjorkman KK, Peter AK, Hay W, Brown LD. Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep. J Endocrinol. 2019 Nov 1. [Epub ahead of print] PubMed PMID: 31751294
Wai SG, Rozance PJ, Wesolowski SR, Hay WW Jr, Brown LD. Prolonged amino acid infusion into intrauterine growth restricted fetal sheep increases leucine oxidation rates. Am J Physiol Endocrinol Metab. 2018 Sep 11. [Epub ahead of print] PubMed PMID: 30205012
Jonker SS, Kamna D, Loturco D, Kailey J, Brown LD. IUGR impairs cardiomyocyte growth and maturation in fetal sheep. J Endocrinol. 2018 Aug 24. [Epub ahead of print] PubMed PMID: 30143557
Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. Pulsatile hyperglycemia increases insulin secretion but not pancreatic ß-cell mass in intrauterine growth-restricted fetal sheep. J Dev Orig Health Dis. 2018 Oct;9(5):492-499. PubMed PMID: 29973299
Stremming JE, Wright CJ, Brown LD. Is paracetamol as effective as indomethacin or ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants?. Acta Paediatr. 2018 Oct;107(10):1836. PubMed PMID: 29873417
Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 Jan 1;596(1):67-82. PubMed PMID: 28940557
Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2017 Sep 22. [Epub ahead of print] PubMed PMID: 28940557
Brown LD, Kohn JR, Rozance PJ, Hay WW Jr, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R654-R663. PubMed PMID: 28179229
Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1;312(4):R492-R500. PubMed PMID: 28100476
Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 Mar;232(3):475-491. PubMed PMID: 28053000
Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW Jr, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct;157(10):3788-3799. PubMed PMID: 27501184
Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R200-8. PubMed PMID: 27170658
Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW Jr, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 Jun;157(6):2447-60. PubMed PMID: 27049667
Hay WW Jr, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug;105(8):881-9. PubMed PMID: 27028695
Brown LD, Hay WW Jr. Impact of placental insufficiency on fetal skeletal muscle growth. Mol Cell Endocrinol. 2016 Nov 5;435:69-77. PubMed PMID: 26994511
Barry JS, Rozance PJ, Brown LD, Anthony RV, Thornburg KL, Hay WW Jr. Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood). 2016 Apr;241(8):839-47. PubMed PMID: 26873920
Brown LD, Rozance PJ. A Sweet Addition for the Treatment of Neonatal Hypoglycemia. J Pediatr. 2016 Mar;170:10-2. PubMed PMID: 26746122
Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;1(1):367-76. PubMed PMID: 25343274
Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW Jr, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R920-8. PubMed PMID: 26224688
Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E306-14. PubMed PMID: 25516551
Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;156(1):367-76. PubMed PMID: 25343274
Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2014 Dec 16;:ajpendo.00396.2014. [Epub ahead of print] PubMed PMID: 25516551
Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18;2(6). PubMed PMID: 24944291
Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014;5(1):28. PubMed PMID: 24917928
Hay WW Jr, Brown LD, Denne SC. Energy requirements, protein-energy metabolism and balance, and carbohydrates in preterm infants. World Rev Nutr Diet. 2014;110:64-81. PubMed PMID: 24751622
Brown LD. Endocrine regulation of fetal skeletal muscle growth: impact on future metabolic health. J Endocrinol. 2014 May;221(2):R13-29. PubMed PMID: 24532817
Brown LD, Hendrickson K, Masor ML, Hay WW Jr. High-protein formulas: evidence for use in preterm infants. Clin Perinatol. 2014 Jun;41(2):383-403. PubMed PMID: 24873839
Lavezzi JR, Thorn SR, O'Meara MC, Loturco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan;304(1):R50-8. PubMed PMID: 23135788
Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
Macko AR, Yates DT, Chen X, Green AS, Kelly AC, Brown LD, Limesand SW. Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced ß-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation. J Dev Orig Health Dis. 2013 Oct 1;4(5). PubMed PMID: 24358443
Brown LD, Hay WW Jr. The nutritional dilemma for preterm infants: how to promote neurocognitive development and linear growth, but reduce the risk of obesity. J Pediatr. 2013 Dec;163(6):1543-5. PubMed PMID: 24018016
Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ß-cell mass in fetal sheep. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E352-62. PubMed PMID: 23211516
Lavezzi JR, Thorn SR, O'Meara MC, LoTurco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 1;304(1):R50-8. PubMed PMID: 23135788
Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. INCREASED AMINO ACID SUPPLY POTENTIATES GLUCOSE STIMULATED INSULIN SECRETION BUT DOES NOT INCREASE BETA CELL MASS IN FETAL SHEEP. Am J Physiol Endocrinol Metab. 2012 Dec 4. [Epub ahead of print] PubMed PMID: 23211516
Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW Jr, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15;303(8):R861-9. PubMed PMID: 22933022
Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW Jr. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E352-64. PubMed PMID: 22649066
Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1483-92. PubMed PMID: 22454287
Thorn SR, Rozance PJ, Brown LD, Hay WW Jr. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med. 2011 May;29(3):225-36. PubMed PMID: 21710398
Care Philosophy
Caring for the entire family of a critically-ill newborn is essential to my practice. I form strong care alliances and trust with families so that I can provide the best care to my patients.
General Information
Medical Schools:
MD, University of Colorado Denver School of Medicine
(1999)
Undergraduate Schools:
BA, University of Colorado - Boulder (CO)
(1995)
Residency Programs:
University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2002)
Fellowships:
University of Colorado (University Hospital) Program, Neonatal-Perinatal Medicine
(2005)