Laura Brown, MD
Professor, Pediatrics-Neonatology

Professional Titles

• Associate Professor of Pediatrics

Recognition & Awards

• President Elect, Perinatal Research Society (2019)
• President Elect, Western Society for Pediatric Research (2019)
• Invited Faculty Member, Annual Seminar on Neonatal-Perinatal Medicine, American Academy of Pediatrics (2016)
• Invited member speaker, Perinatal Research Society (2015)
• Abbott Nutrition Young Investigator Award, Western Society for Pediatric Research (2014)
• Jacqueline Leaffer Travel Award, Center for Women’s Health Research (2014)

Research Interests

Teaching

Publications

• Stremming J, White A, Donthi A, Batt DG, Hetrick B, Chang EI, Wesolowski SR, Seefeldt MB, McCurdy CE, Rozance PJ, Brown LD. Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep. Front Physiol. 2022;13:954948. PubMed PMID: 36091374
• Hesse H, Palmer C, Rigdon CD, Galan HL, Hobbins JC, Brown LD. Differences in body composition and growth persist postnatally in fetuses diagnosed with severe compared to mild fetal growth restriction. J Neonatal Perinatal Med. 2022;15(3):589-598. PubMed PMID: 35342050
• Jones AK, Wang D, Goldstrohm DA, Brown LD, Rozance PJ, Limesand SW, Wesolowski SR. Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep. Am J Physiol Endocrinol Metab. 2022 Feb 1;322(2):E181-E196. PubMed PMID: 34957858
• Stremming J, Chang EI, Knaub LA, Armstrong ML, Baker PR 2nd, Wesolowski SR, Reisdorph N, Reusch JEB, Brown LD. Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth-restricted fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2022 Mar 1;322(3):R228-R240. PubMed PMID: 34907787
• Brown LD, Palmer C, Teynor L, Boehmer BH, Stremming J, Chang EI, White A, Jones AK, Cilvik SN, Wesolowski SR, Rozance PJ. Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency. Reprod Sci. 2022 Jun;29(6):1776-1789. PubMed PMID: 34611848
• Steller JG, Gumina D, Driver C, Palmer C, Brown LD, Reeves S, Hobbins JC, Galan HL. 3D Fractional Limb Volume Identifies Reduced Subcutaneous and Lean Mass in Fetal Growth Restriction. J Ultrasound Med. 2022 Jul;41(7):1623-1632. PubMed PMID: 34580892
• Brown LD, Palmer C, Teynor L, Boehmer BH, Stremming J, Chang EI, White A, Jones AK, Cilvik SN, Wesolowski SR, Rozance PJ. Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency. Reprod Sci. 2021 Oct 5. [Epub ahead of print] PubMed PMID: 34611848
• Steller JG, Gumina D, Driver C, Palmer C, Brown LD, Reeves S, Hobbins JC, Galan HL. 3D Fractional Limb Volume Identifies Reduced Subcutaneous and Lean Mass in Fetal Growth Restriction. J Ultrasound Med. 2021 Sep 28. [Epub ahead of print] PubMed PMID: 34580892
• Jones AK, Rozance PJ, Brown LD, Lorca RA, Julian CG, Moore LG, Limesand SW, Wesolowski SR. Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. Physiol Rep. 2021 Sep;9(18):e15033. PubMed PMID: 34558219
• Rozance PJ, Wesolowski SR, Jonker SS, Brown LD. Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2021 Sep 1;321(3):R352-R363. PubMed PMID: 34287074
• White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ. Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab. 2021 Jun 1;320(6):E1138-E1147. PubMed PMID: 33938236
• Cilvik SN, Wesolowski SR, Anthony RV, Brown LD, Rozance PJ. Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth. J Physiol. 2021 Jul;599(13):3403-3427. PubMed PMID: 33878802
• Tang M, Weaver NE, Berman LM, Brown LD, Hendricks AE, Krebs NF. Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet. Nutrients. 2021 Jan 27;13(2). PubMed PMID: 33513734
• Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 Apr;40:101827. PubMed PMID: 33485059
• Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD. IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus. Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E527-E538. PubMed PMID: 33427051
• Boehmer BH, Wesolowski SR, Brown LD, Rozance PJ. Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep. J Nutr. 2021 Feb 1;151(2):312-319. PubMed PMID: 33326574
• Schinkel ER, Nelson ER, Young BE, Bernstein RM, Taylor SN, Brown LD, Hay WW Jr, Brown KJ, Prenni J. Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants. J Perinatol. 2021 Mar;41(3):582-589. PubMed PMID: 33060780
• Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW Jr, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E721-E733. PubMed PMID: 32830555
• Boehmer BH, Baker PR, Brown LD, Wesolowski SR, Rozance PJ. Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep. J Endocrinol. 2020 Oct;247(1):115-126. PubMed PMID: 32756000
• Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ß Cells in Late-Gestation Sheep. J Nutr. 2020 Aug 1;150(8):2061-2069. PubMed PMID: 32470982
• Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na(+) K(+) -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 Apr;598(8):1625-1639. PubMed PMID: 31909825
• Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW Jr, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E721-E733. PubMed PMID: 32830555
• Boehmer BH, Baker PR, Brown LD, Wesolowski SR, Rozance PJ. Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep. J Endocrinol. 2020 Oct;247(1):115-126. PubMed PMID: 32756000
• Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ß Cells in Late-Gestation Sheep. J Nutr. 2020 Aug 1;150(8):2061-2069. PubMed PMID: 32470982
• Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na( ) K( ) -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 Apr;598(8):1625-1639. PubMed PMID: 31909825
• Schinkel ER, Nelson ER, Young BE, Bernstein RM, Taylor SN, Brown LD, Hay WW Jr, Brown KJ, Prenni J. Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants. J Perinatol. 2020 Oct 15. [Epub ahead of print] PubMed PMID: 33060780
• Chang EI, Wesolowski SR, Gilje EA, Baker PR 2nd, Reisz JA, D'Alessandro A, Hay WW Jr, Rozance PJ, Brown LD. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth restricted fetal sheep hindlimb. Am J Physiol Regul Integr Comp Physiol. 2019 Sep 4. [Epub ahead of print] PubMed PMID: 31483682
• Jones AK, Rozance PJ, Brown LD, Goldstrohm DA, Hay WW Jr, Limesand SW, Wesolowski SR. Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E1-E10. PubMed PMID: 30964701
• Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW Jr, Friedman JE, Wesolowski SR. Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R427-R440. PubMed PMID: 30758974
• Chang EI, Rozance PJ, Wesolowski SR, Nguyen LM, Shaw SC, Sclafani RA, Bjorkman KK, Peter AK, Hay W, Brown LD. Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep. J Endocrinol. 2019 Nov 1. [Epub ahead of print] PubMed PMID: 31751294
• Wai SG, Rozance PJ, Wesolowski SR, Hay WW Jr, Brown LD. Prolonged amino acid infusion into intrauterine growth restricted fetal sheep increases leucine oxidation rates. Am J Physiol Endocrinol Metab. 2018 Sep 11. [Epub ahead of print] PubMed PMID: 30205012
• Jonker SS, Kamna D, Loturco D, Kailey J, Brown LD. IUGR impairs cardiomyocyte growth and maturation in fetal sheep. J Endocrinol. 2018 Aug 24. [Epub ahead of print] PubMed PMID: 30143557
• Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. Pulsatile hyperglycemia increases insulin secretion but not pancreatic ß-cell mass in intrauterine growth-restricted fetal sheep. J Dev Orig Health Dis. 2018 Oct;9(5):492-499. PubMed PMID: 29973299
• Stremming JE, Wright CJ, Brown LD. Is paracetamol as effective as indomethacin or ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants?. Acta Paediatr. 2018 Oct;107(10):1836. PubMed PMID: 29873417
• Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 Jan 1;596(1):67-82. PubMed PMID: 28940557
• Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2017 Sep 22. [Epub ahead of print] PubMed PMID: 28940557
• Brown LD, Kohn JR, Rozance PJ, Hay WW Jr, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R654-R663. PubMed PMID: 28179229
• Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1;312(4):R492-R500. PubMed PMID: 28100476
• Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 Mar;232(3):475-491. PubMed PMID: 28053000
• Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW Jr, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct;157(10):3788-3799. PubMed PMID: 27501184
• Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R200-8. PubMed PMID: 27170658
• Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW Jr, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 Jun;157(6):2447-60. PubMed PMID: 27049667
• Hay WW Jr, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug;105(8):881-9. PubMed PMID: 27028695
• Brown LD, Hay WW Jr. Impact of placental insufficiency on fetal skeletal muscle growth. Mol Cell Endocrinol. 2016 Nov 5;435:69-77. PubMed PMID: 26994511
• Barry JS, Rozance PJ, Brown LD, Anthony RV, Thornburg KL, Hay WW Jr. Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood). 2016 Apr;241(8):839-47. PubMed PMID: 26873920
• Brown LD, Rozance PJ. A Sweet Addition for the Treatment of Neonatal Hypoglycemia. J Pediatr. 2016 Mar;170:10-2. PubMed PMID: 26746122
• Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;1(1):367-76. PubMed PMID: 25343274
• Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW Jr, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R920-8. PubMed PMID: 26224688
• Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E306-14. PubMed PMID: 25516551
• Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;156(1):367-76. PubMed PMID: 25343274
• Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2014 Dec 16;:ajpendo.00396.2014. [Epub ahead of print] PubMed PMID: 25516551
• Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18;2(6). PubMed PMID: 24944291
• Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014;5(1):28. PubMed PMID: 24917928
• Hay WW Jr, Brown LD, Denne SC. Energy requirements, protein-energy metabolism and balance, and carbohydrates in preterm infants. World Rev Nutr Diet. 2014;110:64-81. PubMed PMID: 24751622
• Brown LD. Endocrine regulation of fetal skeletal muscle growth: impact on future metabolic health. J Endocrinol. 2014 May;221(2):R13-29. PubMed PMID: 24532817
• Funk T, Prok L, Brown LD, Bruckner AL. Multifocal vascular tumors and fetal hydrops. J Pediatr. 2014 May;164(5):1214-8. PubMed PMID: 24433827
• Brown LD, Hendrickson K, Masor ML, Hay WW Jr. High-protein formulas: evidence for use in preterm infants. Clin Perinatol. 2014 Jun;41(2):383-403. PubMed PMID: 24873839
• Lavezzi JR, Thorn SR, O'Meara MC, Loturco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan;304(1):R50-8. PubMed PMID: 23135788
• Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
• Macko AR, Yates DT, Chen X, Green AS, Kelly AC, Brown LD, Limesand SW. Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced ß-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation. J Dev Orig Health Dis. 2013 Oct 1;4(5). PubMed PMID: 24358443
• Brown LD, Hay WW Jr. The nutritional dilemma for preterm infants: how to promote neurocognitive development and linear growth, but reduce the risk of obesity. J Pediatr. 2013 Dec;163(6):1543-5. PubMed PMID: 24018016
• Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ß-cell mass in fetal sheep. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E352-62. PubMed PMID: 23211516
• Lavezzi JR, Thorn SR, O'Meara MC, LoTurco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 1;304(1):R50-8. PubMed PMID: 23135788
• Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
• Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. INCREASED AMINO ACID SUPPLY POTENTIATES GLUCOSE STIMULATED INSULIN SECRETION BUT DOES NOT INCREASE BETA CELL MASS IN FETAL SHEEP. Am J Physiol Endocrinol Metab. 2012 Dec 4. [Epub ahead of print] PubMed PMID: 23211516
• Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW Jr, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15;303(8):R861-9. PubMed PMID: 22933022
• Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW Jr. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E352-64. PubMed PMID: 22649066
• Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1483-92. PubMed PMID: 22454287
• Thorn SR, Rozance PJ, Brown LD, Hay WW Jr. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med. 2011 May;29(3):225-36. PubMed PMID: 21710398

Professional Memberships

• American Federation of Medical Research, Member
• Western Society for Pediatric Research (WSPR), Member
• American Academy of Pediatrics, Section of Perinatal Medicine, Member
• Perinatal Research Society (PRS), Member
• Society For Pediatric Research (SPR), Member