Claudia Staab-Weijnitz, PhD

Visiting Associate Professor, Pediatrics-Pulmonary Medicine

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Languages
English, German, Swedish, French
Department
Pediatrics-Pulmonary Medicine

Professional Titles

  • Associate Professor

Publications

  • Chakraborty A, Zöller M, Sardogan A, Klotz M, Mastalerz M, Marchi H, Meixner R, Hatz RA, Behr J, Hilgendorff A, Nakayama M, Staab-Weijnitz CA. Development of a Polidocanol-based Human In Vitro Model to Explore Airway Epithelial Repair. Am J Respir Cell Mol Biol. 2025 Apr 16. [Epub ahead of print] PubMed PMID: 40239015
  • Staab-Weijnitz CA and Lehmann, M. Environmental exposure and the ageing lung. In: “ERS Monograph on Respiratory Physiology: New Knowledge, Better Diagnosis” (Dellacà R. and Aliverti A., eds; ISBN 978-1-84984-187-0), European Respiratory Society, Lausanne, Switzerland; Book chapter (accepted on Nov 20, 2024)
  • Darula Z, McCabe MC, Barrett A, Schmitt LR, Maslanka MD, Saviola AJ, Orgel J, Burlingame A, Staab-Weijnitz CA, Stenmark K, Weaver V, Chalkley RJ, Hansen KC. Proteomic characterization of type I collagen N-terminal crosslinked peptides. Matrix Biol Plus. 2025 Aug;27:100179. PubMed PMID: 40612548
  • Sierra-Marquez J, Schaller L, Sassenbach L, Ramírez-Fernández A, Alt P, Rissiek B, Zimmer B, Schredelseker J, Hector J, Stähler T, Koch-Nolte F, Staab-Weijnitz CA, Dietrich A, Kopp R, Nicke A. Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction. Front Immunol. 2024;15:1425938. PubMed PMID: 38953020
  • Darula Z, McCabe MC, Barrett A, Schmitt LR, Maslanka MD, Saviola AJ, Orgel J, Burlingame A, Staab-Weijnitz CA, Stenmark K, Weaver V, Chalkley RJ, Hansen KC. Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry. bioRxiv. 2024 Mar 31. PubMed PMID: 38585857
  • Staab-Weijnitz CA. A NEAT Discovery Hints at Altered Golgi Signaling in Lung Fibrosis. Am J Respir Cell Mol Biol. 2024 Mar;70(3):155-156. PubMed PMID: 38060429
  • Staab-Weijnitz CA, Onursal C, Nambiar D, Vanacore R. Assessment of Collagen in Translational Models of Lung Research. Adv Exp Med Biol. 2023;1413:213-244. PubMed PMID: 37195533
  • Chen J, Wang X, Schmalen A, Haines S, Wolff M, Ma H, Zhang H, Stoleriu MG, Nowak J, Nakayama M, Bueno M, Brands J, Mora AL, Lee JS, Krauss-Etschmann S, Dmitrieva A, Frankenberger M, Hofer TP, Noessner E, Moosmann A, Behr J, Milger K, Deeg CA, Staab-Weijnitz CA, Hauck SM, Adler H, Goldmann T, Gaede KI, Behrends J, Kammerl IE, Meiners S. Antiviral CD8(+) T-cell immune responses are impaired by cigarette smoke and in COPD. Eur Respir J. 2023 Aug;62(2). PubMed PMID: 37385655
  • Geiger F, Zeitlmayr S, Staab-Weijnitz CA, Rajan S, Breit A, Gudermann T, Dietrich A. An Inhibitory Function of TRPA1 Channels in TGF-ß1-driven Fibroblast-to-Myofibroblast Differentiation. Am J Respir Cell Mol Biol. 2023 Mar;68(3):314-325. PubMed PMID: 36378826
  • Beck C, Ramanujam D, Vaccarello P, Widenmeyer F, Feuerherd M, Cheng CC, Bomhard A, Abikeeva T, Schädler J, Sperhake JP, Graw M, Safi S, Hoffmann H, Staab-Weijnitz CA, Rad R, Protzer U, Frischmuth T, Engelhardt S. Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage. Nat Commun. 2023 Jul 28;14(1):4564. PubMed PMID: 37507393
  • Nakayama M, Marchi H, Dmitrieva AM, Chakraborty A, Merl-Pham J, Hennen E, Le Gleut R, Ruppert C, Guenther A, Kahnert K, Behr J, Hilgendorff A, Hauck SM, Adler H, Staab-Weijnitz CA. Quantitative proteomics of differentiated primary bronchial epithelial cells from chronic obstructive pulmonary disease and control identifies potential novel host factors post-influenza A virus infection. Front Microbiol. 2022;13:957830. PubMed PMID: 36713229
  • Berthold EJ, Ma-Lauer Y, Chakraborty A, von Brunn B, Hilgendorff A, Hatz R, Behr J, Hausch F, Staab-Weijnitz CA, von Brunn A. Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models. Front Cell Infect Microbiol. 2022;12:958634. PubMed PMID: 36211973
  • Zeitlmayr S, Zierler S, Staab-Weijnitz CA, Dietrich A, Geiger F, Horgen FD, Gudermann T, Breit A. TRPM7 restrains plasmin activity and promotes transforming growth factor-ß1 signaling in primary human lung fibroblasts. Arch Toxicol. 2022 Oct;96(10):2767-2783. PubMed PMID: 35864199
  • Mastalerz M, Dick E, Chakraborty A, Hennen E, Schamberger AC, Schröppel A, Lindner M, Hatz R, Behr J, Hilgendorff A, Schmid O, Staab-Weijnitz CA. Validation of in vitro models for smoke exposure of primary human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2022 Jan 1;322(1):L129-L148. PubMed PMID: 34668416
  • Staab-Weijnitz CA. Fighting the Fiber: Targeting Collagen in Lung Fibrosis. Am J Respir Cell Mol Biol. 2022 Apr;66(4):363-381. PubMed PMID: 34861139
  • Krick S, Geraghty P, Jourdan Le Saux C, Rojas M, Staab-Weijnitz CA. Editorial: Defining and Characterizing Respiratory Disease in an Aging Population. Front Med (Lausanne). 2022;9:889834. PubMed PMID: 35462999
  • Preisendörfer S, Ishikawa Y, Hennen E, Winklmeier S, Schupp JC, Knüppel L, Fernandez IE, Binzenhöfer L, Flatley A, Juan-Guardela BM, Ruppert C, Guenther A, Frankenberger M, Hatz RA, Kneidinger N, Behr J, Feederle R, Schepers A, Hilgendorff A, Kaminski N, Meinl E, Bächinger HP, Eickelberg O, Staab-Weijnitz CA. FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Cells. 2022 Apr 14;11(8). PubMed PMID: 35456020
  • Chakraborty A, Mastalerz M, Ansari M, Schiller HB, Staab-Weijnitz CA. Emerging Roles of Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis. Cells. 2022 Mar 19;11(6). PubMed PMID: 35326501
  • Kratzel A, Kelly JN, V'kovski P, Portmann J, Brüggemann Y, Todt D, Ebert N, Shrestha N, Plattet P, Staab-Weijnitz CA, von Brunn A, Steinmann E, Dijkman R, Zimmer G, Pfaender S, Thiel V. A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets. PLoS Biol. 2021 Dec;19(12):e3001490. PubMed PMID: 34962926
  • Merl-Pham J, Basak T, Knüppel L, Ramanujam D, Athanason M, Behr J, Engelhardt S, Eickelberg O, Hauck SM, Vanacore R, Staab-Weijnitz CA. Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an in vitro model of lung fibrosis. Matrix Biol Plus. 2019 Feb;1:100005. PubMed PMID: 33543004
  • Andrault PM, Schamberger AC, Chazeirat T, Sizaret D, Renault J, Staab-Weijnitz CA, Hennen E, Petit-Courty A, Wartenberg M, Saidi A, Baranek T, Guyetant S, Courty Y, Eickelberg O, Lalmanach G, Lecaille F. Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD. Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L625-L638. PubMed PMID: 31553637
  • Maldonado M, Salgado-Aguayo A, Herrera I, Cabrera S, Ortíz-Quintero B, Staab-Weijnitz CA, Eickelberg O, Ramírez R, Manicone AM, Selman M, Pardo A. Upregulation and Nuclear Location of MMP28 in Alveolar Epithelium of Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 Jul;59(1):77-86. PubMed PMID: 29373068
  • Zhang W, Ohno S, Steer B, Klee S, Staab-Weijnitz CA, Wagner D, Lehmann M, Stoeger T, Königshoff M, Adler H. S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis. Front Immunol. 2018;9:1216. PubMed PMID: 29910813
  • Knüppel L, Heinzelmann K, Lindner M, Hatz R, Behr J, Eickelberg O, Staab-Weijnitz CA. FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis. Respir Res. 2018 Apr 19;19(1):67. PubMed PMID: 29673351
  • Schiller HB, Mayr CH, Leuschner G, Strunz M, Staab-Weijnitz C, Preisendörfer S, Eckes B, Moinzadeh P, Krieg T, Schwartz DA, Hatz RA, Behr J, Mann M, Eickelberg O. Deep Proteome Profiling Reveals Common Prevalence of MZB1-Positive Plasma B Cells in Human Lung and Skin Fibrosis. Am J Respir Crit Care Med. 2017 Nov 15;196(10):1298-1310. PubMed PMID: 28654764
  • Alsafadi HN, Staab-Weijnitz CA, Lehmann M, Lindner M, Peschel B, Königshoff M, Wagner DE. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L896-L902. PubMed PMID: 28314802
  • Loerz C, Staab-Weijnitz C, Huebbe P, Giller K, Metges C, Rimbach G, Maser E. Regulation of 11ß-hydroxysteroid dehydrogenase type 1 following caloric restriction and re-feeding is species dependent. Chem Biol Interact. 2017 Oct 1;276:95-104. PubMed PMID: 28254522
  • Knüppel L, Ishikawa Y, Aichler M, Heinzelmann K, Hatz R, Behr J, Walch A, Bächinger HP, Eickelberg O, Staab-Weijnitz CA. A Novel Antifibrotic Mechanism of Nintedanib and Pirfenidone. Inhibition of Collagen Fibril Assembly. Am J Respir Cell Mol Biol. 2017 Jul;57(1):77-90. PubMed PMID: 28257580
  • Mossina A, Lukas C, Merl-Pham J, Uhl FE, Mutze K, Schamberger A, Staab-Weijnitz C, Jia J, Yildirim AÖ, Königshoff M, Hauck SM, Eickelberg O, Meiners S. Cigarette smoke alters the secretome of lung epithelial cells. Proteomics. 2017 Jan;17(1-2). PubMed PMID: 27891773
  • Staab-Weijnitz CA, Eickelberg O. Repositioning compounds from cancer drug discovery to IPF: PI3K inhibition. Thorax. 2016 Aug;71(8):675-6. PubMed PMID: 27307018
  • Schamberger AC, Schiller HB, Fernandez IE, Sterclova M, Heinzelmann K, Hennen E, Hatz R, Behr J, Vašáková M, Mann M, Eickelberg O, Staab-Weijnitz CA. Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease. Sci Rep. 2016 Jul 20;6:29952. PubMed PMID: 27435875
  • Schamberger AC, Staab-Weijnitz CA, Mise-Racek N, Eickelberg O. Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface. Sci Rep. 2015 Feb 2;5:8163. PubMed PMID: 25641363
  • Staab-Weijnitz CA, Fernandez IE, Knüppel L, Maul J, Heinzelmann K, Juan-Guardela BM, Hennen E, Preissler G, Winter H, Neurohr C, Hatz R, Lindner M, Behr J, Kaminski N, Eickelberg O. FK506-Binding Protein 10, a Potential Novel Drug Target for Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2015 Aug 15;192(4):455-67. PubMed PMID: 26039104
  • Herold S, Staab-Weijnitz CA. Glutathione on the fas track. A novel drug target for the treatment of pseudomonas infection?. Am J Respir Crit Care Med. 2014 Feb 15;189(4):386-9. PubMed PMID: 24528316
  • Velroyen A, Bech M, Zanette I, Schwarz J, Rack A, Tympner C, Herrler T, Staab-Weijnitz C, Braunagel M, Reiser M, Bamberg F, Pfeiffer F, Notohamiprodjo M. X-ray phase-contrast tomography of renal ischemia-reperfusion damage. PLoS One. 2014;9(10):e109562. PubMed PMID: 25299243
  • Han Y, Staab-Weijnitz CA, Xiong G, Maser E. Identification of microRNAs as a potential novel regulatory mechanism in HSD11B1 expression. J Steroid Biochem Mol Biol. 2013 Jan;133:129-39. PubMed PMID: 23017470
  • Hartmanová T, Tambor V, Lenco J, Staab-Weijnitz CA, Maser E, Wsól V. S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity. Chem Biol Interact. 2013 Feb 25;202(1-3):136-45. PubMed PMID: 23295225
  • Blum A, Loerz C, Martin HJ, Staab-Weijnitz CA, Maser E. Momordica charantia extract, a herbal remedy for type 2 diabetes, contains a specific 11ß-hydroxysteroid dehydrogenase type 1 inhibitor. J Steroid Biochem Mol Biol. 2012 Jan;128(1-2):51-5. PubMed PMID: 22001161
  • Staab CA, Hartmanová T, El-Hawari Y, Ebert B, Kisiela M, Wsol V, Martin HJ, Maser E. Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3. Chem Biol Interact. 2011 May 30;191(1-3):95-103. PubMed PMID: 21256830
  • Staab CA, Stegk JP, Haenisch S, Neiss E, Köbsch K, Ebert B, Cascorbi I, Maser E. Analysis of alternative promoter usage in expression of HSD11B1 including the development of a transcript-specific quantitative real-time PCR method. Chem Biol Interact. 2011 May 30;191(1-3):104-12. PubMed PMID: 21215738
  • Hellgren M, Carlsson J, Ostberg LJ, Staab CA, Persson B, Höög JO. Enrichment of ligands with molecular dockings and subsequent characterization for human alcohol dehydrogenase 3. Cell Mol Life Sci. 2010 Sep;67(17):3005-15. PubMed PMID: 20405162
  • Staab CA, Maser E. 11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation. J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):56-72. PubMed PMID: 20045052
  • Staab CA, Alander J, Morgenstern R, Grafström RC, Höög JO. The Janus face of alcohol dehydrogenase 3. Chem Biol Interact. 2009 Mar 16;178(1-3):29-35. PubMed PMID: 19038239
  • Staab CA, Hellgren M, Grafström RC, Höög JO. Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3. Chem Biol Interact. 2009 Jun 15;180(1):113-8. PubMed PMID: 19428350
  • Staab CA, Ceder R, Roberg K, Grafström RC, Höög JO. Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes. Cell Mol Life Sci. 2008 Nov;65(22):3653-63. PubMed PMID: 18854940
  • Staab CA, Hellgren M, Höög JO. Medium- and short-chain dehydrogenase/reductase gene and protein families : Dual functions of alcohol dehydrogenase 3: implications with focus on formaldehyde dehydrogenase and S-nitrosoglutathione reductase activities. Cell Mol Life Sci. 2008 Dec;65(24):3950-60. PubMed PMID: 19011746
  • Staab CA, Alander J, Brandt M, Lengqvist J, Morgenstern R, Grafström RC, Höög JO. Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors. Biochem J. 2008 Aug 1;413(3):493-504. PubMed PMID: 18412547
  • Staab CA, Ceder R, Jägerbrink T, Nilsson JA, Roberg K, Jörnvall H, Höög JO, Grafström RC. Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma. J Proteome Res. 2007 Sep;6(9):3705-17. PubMed PMID: 17696463
  • Ceder R, Merne M, Staab CA, Nilsson JA, Höög JO, Dressler D, Engelhart K, Grafström RC. The application of normal, SV40 T-antigen-immortalised and tumour-derived oral keratinocytes, under serum-free conditions, to the study of the probability of cancer progression as a result of environmental exposure to chemicals. Altern Lab Anim. 2007 Dec;35(6):621-39. PubMed PMID: 18186669
  • Wunderlich M, Martin A, Staab CA, Schmid FX. Evolutionary protein stabilization in comparison with computational design. J Mol Biol. 2005 Sep 2;351(5):1160-8. PubMed PMID: 16051264
  • Staab CA, Vondracek M, Custodio H, Johansson K, Nilsson JA, Morgan P, Höög JO, Cotgreave I, Grafström RC. Modelling of normal and premalignant oral tissue by using the immortalised cell line, SVpgC2a: a review of the value of the model. Altern Lab Anim. 2004 Oct;32(4):401-5. PubMed PMID: 15651925
  • Nilsson JA, Hedberg JJ, Vondracek M, Staab CA, Hansson A, Höög JO, Grafström RC. Alcohol dehydrogenase 3 transcription associates with proliferation of human oral keratinocytes. Cell Mol Life Sci. 2004 Mar;61(5):610-617. PubMed PMID: 15004699

Public Speaking
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