Alison Liu, MD, PhD, MPH

Professional Titles

• Associate Research Professor

Recognitions

• Philip and Elaine Ellis New Investigator in Ophthalmology Research Award, Sue Anschutz-Rodgers Eye Center, Department of Ophthalmology, University of Colorado School of Medicine (2023)

Research Interests

Since the appointment of my current position as assistant research professor at CU Anschutz in 2021, with my involvement in dry eye research and the recent emphasis on upstream drivers of differences in health outcomes, I am intrigued by the challenging task to identify multi-level, multidimensional barriers to accessing eye care by dry eye patients and how those inequities lead to unfavorable prognosis of dry eye. Coupling with my expertise and experiences in evidence synthesis, my long-term career goal is to generate and dissemination quality scientific knowledge that can be further translated into clinical practice or public health policies. With the strong support from the collaborators in the team and the rich resources provided by the Department and the University, I am optimistic about the positive contributions made from the proposed work.

Publications

• Piyasena MP, Daka Q, Qureshi R, Roberti G, Michelessi M, Liu SH, Li T, Takwoingi Y, Azuara-Blanco A, Virgili G. Prognostic factors associated with progression of open-angle glaucoma in adults. Cochrane Database Syst Rev. 2025 Dec 10;12(12):CD015436. PubMed PMID: 41370133
• Kruoch Z, Choo AY, Kemp A, Gonzales M, Yim TW, McCann P, Liu SH, Ting DSJ, Kuo IC. Medical and surgical interventions for neurotrophic keratopathy. Cochrane Database Syst Rev. 2025 Dec 5;12(12):CD015723. PubMed PMID: 41347649
• Chong P, Young BK, McNamara S, Ng SM, Liu SH, Li T, Campbell JP, Kalpathy-Cramer J, Singh P. Artificial intelligence-based algorithms for the diagnosis of retinopathy of prematurity. Cochrane Database Syst Rev. 2025 Oct 7;10(10):CD016047. PubMed PMID: 41055082
• Leslie L, Liu SH, Kuo IC. Topical ophthalmic anesthetics for corneal abrasions: findings from a Cochrane systematic review and meta-analysis. Commun Med (Lond). 2025 Sep 24;5(1):393. PubMed PMID: 40993211
• Liu SH, Mandava N, Li T. Metformin and Age-Related Macular Degeneration-No Causal Evidence Yet. JAMA Ophthalmol. 2025 Oct 1;143(10):853-854. PubMed PMID: 40965880
• Srinivasan G, Kerber KL, Liu SH, Manh VM, Huang K, Williamson A, Sadhu S, Ollinger MC, Tajbakhsh Z, Fisher JH, Cheung NL, Junge J, Chan KCH, Hussaindeen JR, Simard P, Trast KR, Morettin CE, Krueger S, Nti AN, Lee Chen DM, Roberts TL. Optical correction of hyperopia in school-aged children: a scoping review protocol. BMJ Open. 2025 Aug 17;15(8):e103546. PubMed PMID: 40819922
• Tiong EWW, Soon CYS, Ong ZZ, Liu SH, Qureshi R, Rauz S, Ting DSJ. Deep learning for diagnosing and grading pterygium: A systematic review and meta-analysis. Comput Biol Med. 2025 Sep;196(Pt A):110743. PubMed PMID: 40644893
• Assi L, Lutfallah SC, Yim TW, Liu SH, Duffy SJ, Weiss J. Topical lifitegrast therapy for dry eye disease. Cochrane Database Syst Rev. 2025 Jun 20;6(6):CD016117. PubMed PMID: 40539519
• Vemulapalli K, Gandhewar R, Safitri A, Ng SM, Michelessi M, Azuara-Blanco A, Liu SH, Virgili G, Hu K. Artificial intelligence for glaucoma. Cochrane Database Syst Rev. 2025 Jun 17;6(6):CD016114. PubMed PMID: 40525544
• Abbott KS, Gregory DG, Liu SH. Cochrane corner: lubricating drops for contact lens discomfort in adults. Eye (Lond). 2025 Aug;39(12):2330-2331. PubMed PMID: 40399650
• Lan HM, Wu CC, Liu SH, Li CH, Tu YK, Chen KF. Comparison of the diagnostic accuracies of various biomarkers and scoring systems for sepsis: A systematic review and Bayesian diagnostic test accuracy network meta-analysis. J Crit Care. 2025 Aug;88:155087. PubMed PMID: 40245524
• Chen AM, Salzano AD, Burgher AP, Greenspan LD, Yap TP, Theis J, Liu SH, Scheiman M, Roberts TL. Scoping review: Intervention for ocular motor disorders in children and adults with mild traumatic brain injury. Optom Vis Sci. 2025 Apr 1;102(4):204-214. PubMed PMID: 39951336
• Liu SH, Chen YY, Nurmatov U, van Schayck OCP, Kuo IC. Antibiotics Versus Placebo for Acute Bacterial Conjunctivitis: Findings From a Cochrane Systematic Review. Am J Ophthalmol. 2024 Jan;257:143-153. PubMed PMID: 37482371
• Ong ZZ, Sadek Y, Qureshi R, Liu SH, Li T, Liu X, Takwoingi Y, Sounderajah V, Ashrafian H, Ting DSW, Mehta JS, Rauz S, Said DG, Dua HS, Burton MJ, Ting DSJ. Diagnostic performance of deep learning for infectious keratitis: a systematic review and meta-analysis. EClinicalMedicine. 2024 Nov;77:102887. PubMed PMID: 39469534
• Kang C, Lo JE, Zhang H, Ng SM, Lin JC, Scott IU, Kalpathy-Cramer J, Liu SA, Greenberg PB. Artificial intelligence for diagnosing exudative age-related macular degeneration. Cochrane Database Syst Rev. 2024 Oct 17;10(10):CD015522. PubMed PMID: 39417312
• Tiong EWW, Liu SH, Ting DSJ. Cochrane corner: artificial intelligence for keratoconus. Eye (Lond). 2024 Dec;38(18):3406-3408. PubMed PMID: 39300189
• Caffery B, Pucker AD, Chidi-Egboka NC, Obinwanne CJ, Harkness B, Carnt NA, Liu SH, Ng A. Lubricating drops for contact lens discomfort in adults. Cochrane Database Syst Rev. 2024 Sep 5;9(9):CD015751. PubMed PMID: 39234924
• Liu SH, Virgili G. Cochrane Corner: Anti-vascular endothelial growth factor biosimilar for macular degeneration. Eye (Lond). 2024 Nov;38(16):3045-3046. PubMed PMID: 39030410
• Kuo I, Leslie L, Liu SH. Topical Ophthalmic Anesthetics for CornealAbrasions: Findings from a Cochrane SystematicReview and Meta-Analysis. Res Sq. 2024 Jun 4. PubMed PMID: 38883773
• Liu SH, Hawkins BS. Does Systemic Fluoroquinolone Use Increase Risk of Retinal Detachment?. JAMA Ophthalmol. 2024 Jul 1;142(7):646-647. PubMed PMID: 38814580
• Fung TH, Yim TW, Lois N, Wright DM, Liu SH, Williamson T. Face-down positioning or posturing after pars plana vitrectomy for macula-involving rhegmatogenous retinal detachments. Cochrane Database Syst Rev. 2024 Mar 15;3(3):CD015514. PubMed PMID: 38488250
• Saldanha IJ, Petris R, Ifantides C, Hauswirth SG, Gregory DG, Qureshi R, McCann P, Liu SH, Abraham AG, Li T. Patient barriers and facilitators for making environmental and behavioral modifications for dry eye in the United States. Optom Vis Sci. 2024 Feb 1;101(2):84-89. PubMed PMID: 38408305
• Chen H, McCann P, Lien T, Xiao M, Abraham AG, Gregory DG, Hauswirth SG, Qureshi R, Liu SH, Saldanha IJ, Li T. Prevalence of dry eye and Meibomian gland dysfunction in Central and South America: a systematic review and meta-analysis. BMC Ophthalmol. 2024 Jan 31;24(1):50. PubMed PMID: 38297204
• Liu SH, Shaughnessy D, Leslie L, Abbott K, Abraham AG, McCann P, Saldanha IJ, Qureshi R, Li T. Social Determinants of Dry Eye in the United States: A Systematic Review. Am J Ophthalmol. 2024 May;261:36-53. PubMed PMID: 38242339
• Liu SH, Chen YY, Nurmatov U, van Schayck OCP, Kuo IC. Antibiotics Versus Placebo for Acute Bacterial Conjunctivitis: Findings From a Cochrane Systematic Review. Am J Ophthalmol. 2024 Jan;257:143-153. PubMed PMID: 37482371
• Chen KF, Feng TW, Wu CC, Yunusa I, Liu SH, Yeh CF, Han ST, Mao CY, Harika D, Rothman R, Pekosz A. Diagnostic accuracy of clinical signs and symptoms of COVID-19: A systematic review and meta-analysis to investigate the different estimates in a different stage of the pandemic outbreak. J Glob Health. 2023 Jul 14;13:06026. PubMed PMID: 37441773
• Ong ZZ, Sadek Y, Liu X, Qureshi R, Liu SH, Li T, Sounderajah V, Ashrafian H, Ting DSW, Said DG, Mehta JS, Burton MJ, Dua HS, Ting DSJ. Diagnostic performance of deep learning in infectious keratitis: a systematic review and meta-analysis protocol. BMJ Open. 2023 May 10;13(5):e065537. PubMed PMID: 37164459
• Nucci P, Liu SH, Villani E. Cochrane corner: interventions for myopia control in children. Eye (Lond). 2023 Dec;37(17):3526-3527. PubMed PMID: 37142779
• Sullivan DA, da Costa AX, Del Duca E, Doll T, Grupcheva CN, Lazreg S, Liu SH, McGee SR, Murthy R, Narang P, Ng A, Nistico S, O'Dell L, Roos J, Shen J, Markoulli M. TFOS Lifestyle: Impact of cosmetics on the ocular surface. Ocul Surf. 2023 Jul;29:77-130. PubMed PMID: 37061220
• Downie LE, Britten-Jones AC, Hogg RE, Jalbert I, Li T, Lingham G, Liu SH, Qureshi R, Saldanha IJ, Singh S, Craig JP. TFOS Lifestyle - Evidence quality report: Advancing the evaluation and synthesis of research evidence. Ocul Surf. 2023 Apr;28:200-212. PubMed PMID: 37054912
• Chen YY, Liu SH, Nurmatov U, van Schayck OC, Kuo IC. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev. 2023 Mar 13;3(3):CD001211. PubMed PMID: 36912752
• Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG. Corticosteroid implants for chronic non-infectious uveitis. Cochrane Database Syst Rev. 2023 Jan 16;1(1):CD010469. PubMed PMID: 36645716
• Liu SH, Kuo IC. Topical antibiotics and artificial tears associated with reduced infective-conjunctivitis symptoms. J Pediatr. 2023 Oct;261:113320. PubMed PMID: 37741681
• Li T, McCann PM, Wilting S, McNamara S, Gregory DG, Hauswirth SG, Ifantides C, Benning L, Sequeira TA, Qureshi R, Liu SH, Clark MA, Saldanha IJ, Abraham AG. Prolonged facemask wearing among hospital workers and dry eye - a mixed-methods study. BMC Ophthalmol. 2023 Oct 19;23(1):420. PubMed PMID: 37858059
• Liu SH, Kuo IC. Topical antibiotics and artificial tears associated with reduced infective-conjunctivitis symptoms. J Pediatr. 2023 Oct;261:113320. PubMed PMID: 37741681
• Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG. Corticosteroid implants for chronic non-infectious uveitis. Cochrane Database Syst Rev. 2023 Aug 29;8(8):CD010469. PubMed PMID: 37642198
• Sulewski M, Leslie L, Liu SH, Ifantides C, Cho K, Kuo IC. Topical ophthalmic anesthetics for corneal abrasions. Cochrane Database Syst Rev. 2023 Aug 9;8(8):CD015091. PubMed PMID: 37555621
• Downie LE, Britten-Jones AC, Hogg RE, Jalbert I, Li T, Lingham G, Liu SH, Qureshi R, Saldanha IJ, Singh S, Craig JP. TFOS Lifestyle - Evidence quality report: Advancing the evaluation and synthesis of research evidence. Ocul Surf. 2023 Apr;28:200-212. PubMed PMID: 37054912
• Sullivan DA, da Costa AX, Del Duca E, Doll T, Grupcheva CN, Lazreg S, Liu SH, McGee SR, Murthy R, Narang P, Ng A, Nistico S, O'Dell L, Roos J, Shen J, Markoulli M. TFOS Lifestyle: Impact of cosmetics on the ocular surface. Ocul Surf. 2023 Jul;29:77-130. PubMed PMID: 37061220
• Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG. Corticosteroid implants for chronic non-infectious uveitis. Cochrane Database Syst Rev. 2023 Aug 29;8(8):CD010469. PubMed PMID: 37642198
• Sulewski M, Leslie L, Liu SH, Ifantides C, Cho K, Kuo IC. Topical ophthalmic anesthetics for corneal abrasions. Cochrane Database Syst Rev. 2023 Aug 9;8:CD015091. PubMed PMID: 37555621
• Liu SH, Chen YY, Nurmatov U, van Schayck OC, Kuo IC. Antibiotics versus placebo for acute bacterial conjunctivitis: findings from a Cochrane Systematic Review. Am J Ophthalmol. 2023 Jul 21. [Epub ahead of print] PubMed PMID: 37482371
• Chen KF, Feng TW, Wu CC, Yunusa I, Liu SH, Yeh CF, Han ST, Mao CY, Harika D, Rothman R, Pekosz A. Diagnostic accuracy of clinical signs and symptoms of COVID-19: A systematic review and meta-analysis to investigate the different estimates in a different stage of the pandemic outbreak. J Glob Health. 2023 Jul 14;13:06026. PubMed PMID: 37441773
• Ong ZZ, Sadek Y, Liu X, Qureshi R, Liu SH, Li T, Sounderajah V, Ashrafian H, Ting DSW, Said DG, Mehta JS, Burton MJ, Dua HS, Ting DSJ. Diagnostic performance of deep learning in infectious keratitis: a systematic review and meta-analysis protocol. BMJ Open. 2023 May 10;13(5):e065537. PubMed PMID: 37164459
• Nucci P, Liu SH, Villani E. Cochrane corner: interventions for myopia control in children. Eye (Lond). 2023 May 4. [Epub ahead of print] PubMed PMID: 37142779
• Chen YY, Liu SH, Nurmatov U, van Schayck OC, Kuo IC. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev. 2023 Mar 13;3(3):CD001211. PubMed PMID: 36912752
• Liu SH, Hawkins BS, Ng SM, Ren M, Leslie L, Han G, Kuo IC. Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis. Cochrane Database Syst Rev. 2022 Mar 3;3(3):CD013520. PubMed PMID: 35238405
• Liu SH, Hawkins BS, Ren M, Ng SM, Leslie L, Han G, Kuo IC. Topical Pharmacologic Interventions Versus Active Control, Placebo, or No Treatment for Epidemic Keratoconjunctivitis: Findings From a Cochrane Systematic Review. Am J Ophthalmol. 2022 Aug;240:265-275. PubMed PMID: 35331686
• Liu SH, Saldanha IJ, Abraham AG, Rittiphairoj T, Hauswirth S, Gregory D, Ifantides C, Li T. Topical corticosteroids for dry eye. Cochrane Database Syst Rev. 2022 Oct 21;10(10):CD015070. PubMed PMID: 36269562
• McCann P, Abraham AG, Mukhopadhyay A, Panagiotopoulou K, Chen H, Rittiphairoj T, Gregory DG, Hauswirth SG, Ifantides C, Qureshi R, Liu SH, Saldanha IJ, Li T. Prevalence and Incidence of Dry Eye and Meibomian Gland Dysfunction in the United States: A Systematic Review and Meta-analysis. JAMA Ophthalmol. 2022 Dec 1;140(12):1181-1192. PubMed PMID: 36301551
• Wingert AM, Liu SH, Lin JC, Sridhar J. Non-steroidal anti-inflammatory agents for treating cystoid macular edema following cataract surgery. Cochrane Database Syst Rev. 2022 Dec 15;12(12):CD004239. PubMed PMID: 36520144
• Sena DF, Kilian R, Liu SH, Rizzo S, Virgili G. Pneumatic retinopexy versus scleral buckle for repairing simple rhegmatogenous retinal detachments. Cochrane Database Syst Rev. 2021 Nov 11;11:CD008350. PubMed PMID: 34762741
• Weng HJ, Shih MH, Tsai TF, Song YC, Pan YC, Hu JY, Chung-Yee Hui R, Lee WR, Huang YH, Liu SH. Clinical validation and utility of Chinese Eppendorf Itch Questionnaire in adults with chronic pruritus symptoms. J Formos Med Assoc. 2021 Jan;120(1 Pt 2):492-500. PubMed PMID: 32600865
• Liu SH, Yu HY, Chang YC, Chung-Yee Hui R, Huang YC, Huang YH. Host characteristics and dynamics of Staphylococcus aureus colonization in patients with moderate-to-severe psoriasis before and after treatment: A prospective cohort study. J Am Acad Dermatol. 2019 Aug;81(2):605-607. PubMed PMID: 29803905
• Kuo G, Chen SW, Huang JY, Wu CY, Fu CM, Chang CH, Liu SH, Chan YH, Wu IW, Yang HY. Short-term heart rate variability as a predictor of long-term survival in patients with chronic hemodialysis: A prospective cohort study. J Formos Med Assoc. 2018 Dec;117(12):1058-1064. PubMed PMID: 30293929
• Liu SH, Huang YC, Chen LY, Yu SC, Yu HY, Chuang SS. The skin microbiome of wound scars and unaffected skin in patients with moderate to severe burns in the subacute phase. Wound Repair Regen. 2018 Mar;26(2):182-191. PubMed PMID: 29663582
• Chen KF, Liu SH, Li CH, Wu CC, Chaou CH, Tzeng IS, Hsieh YH, Blaney GN, Liu ZY, Han ST, Chan YL. Development and validation of a parsimonious and pragmatic CHARM score to predict mortality in patients with suspected sepsis. Am J Emerg Med. 2017 Apr;35(4):640-646. PubMed PMID: 27832977
• Ng CY, Huang YH, Chu CF, Wu TC, Liu SH. Risks for Staphylococcus aureus colonization in patients with psoriasis: a systematic review and meta-analysis. Br J Dermatol. 2017 Oct;177(4):967-977. PubMed PMID: 28160277
• Liu SH, Chen KF, Chen CJ, Lin YH, Huang YC. Intermittent nasal carriage with Staphylococcus aureus within a menstrual cycle: Results from a prospective cohort of healthy carriers. Medicine (Baltimore). 2016 Jun;95(26):e4040. PubMed PMID: 27368032
• Hsu CY, Liu SH, Chao CH, Chan YL, Tsai TC, Chen LM, Wu CC, Chen KF. STROBE-compliant article: Blood Transfusions within the First 24 Hours of Hospitalization Did Not Impact Mortality Among Patients with Severe Sepsis. Medicine (Baltimore). 2016 Jan;95(4):e2601. PubMed PMID: 26825911
• Tzeng IS, Liu SH, Chiou YT, Huang CH, Lee CJ, Chien CY, Hsu SC, Weng YM, Chen KF, Chen JC. Predicting emergency departments visit rates from septicemia in Taiwan using an age-period-cohort model, 1998 to 2012. Medicine (Baltimore). 2016 Dec;95(50):e5598. PubMed PMID: 27977595
• Liu SH, Tseng CY, Lin CC. Is neostigmine effective in severe pufferfish-associated tetrodotoxin poisoning?. Clin Toxicol (Phila). 2015 Jan;53(1):13-21. PubMed PMID: 25410493
• Shih MH, Lazo M, Liu SH, Bonekamp S, Hernaez R, Clark JM. Association between serum uric acid and nonalcoholic fatty liver disease in the US population. J Formos Med Assoc. 2015 Apr;114(4):314-20. PubMed PMID: 25839764
• Yang HY, Hung CC, Liu SH, Guo YG, Chen YC, Ko YC, Huang CT, Chou LF, Tian YC, Chang MY, Hsu HH, Lin MY, Hwang SJ, Yang CW. Overlooked Risk for Chronic Kidney Disease after Leptospiral Infection: A Population-Based Survey and Epidemiological Cohort Evidence. PLoS Negl Trop Dis. 2015;9(10):e0004105. PubMed PMID: 26452161
• Liu SH, Chen HJ, Hsieh TH, Chen JC, Huang YC. Excessive adiposity, metabolic health, and risks for genital human papillomavirus infection in adult women: a population-based cross-sectional study. BMC Obes. 2015;2:39. PubMed PMID: 26442154
• Huynh L, Johns B, Liu SH, Vedula SS, Li T, Puhan MA. Cost-effectiveness of health research study participant recruitment strategies: a systematic review. Clin Trials. 2014 Oct;11(5):576-83. PubMed PMID: 24980278
• Liu SH, Cummings DA, Zenilman JM, Gravitt PE, Brotman RM. Characterizing the temporal dynamics of human papillomavirus DNA detectability using short-interval sampling. Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):200-8. PubMed PMID: 24130223
• Liu SH, Rositch AF, Viscidi RP, Silver MI, Burke AE, Gravitt PE. Obesity and human papillomavirus infection in perimenopausal women. J Infect Dis. 2013 Oct 1;208(7):1071-80. PubMed PMID: 23840046
• Liu SH, Lazo M, Koteish A, Kao WH, Shih MH, Bonekamp S, Hernaez R, Clark JM. Oral contraceptive pill use is associated with reduced odds of nonalcoholic fatty liver disease in menstruating women: results from NHANES III. J Gastroenterol. 2013 Oct;48(10):1151-9. PubMed PMID: 23188092
• Liu SH, Brotman RM, Zenilman JM, Gravitt PE, Cummings DA. Menstrual cycle and detectable human papillomavirus in reproductive-age women: a time series study. J Infect Dis. 2013 Nov 1;208(9):1404-15. PubMed PMID: 23885113
• Bennett WL, Liu SH, Yeh HC, Nicholson WK, Gunderson EP, Lewis CE, Clark JM. Changes in weight and health behaviors after pregnancies complicated by gestational diabetes mellitus: the CARDIA study. Obesity (Silver Spring). 2013 Jun;21(6):1269-75. PubMed PMID: 23666593
• Liu SH, Srikrishnan AK, Zelaya CE, Solomon S, Celentano DD, Sherman SG. Measuring perceived stigma in female sex workers in Chennai, India. AIDS Care. 2011 May;23(5):619-27. PubMed PMID: 21293991

Professional Memberships

• ARVO, Member

Practice Locations

Hospital Affiliation

• University of Colorado Hospital