Darleen Sandoval, PhD
Professor, Pediatrics-Nutrition

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Department: Pediatrics-Nutrition

Publications

  • Vollbrecht PJ, Nesbitt KM, Addis VM, Boulnemour KM, Micheli DA, Smith KB, Sandoval DA, Kennedy RT, Ferrario CR. Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats. J Neurochem. 2022 Nov 6. [Epub ahead of print] PubMed PMID: 36336816
  • Sandoval DA, Patti ME. Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia. Nat Rev Endocrinol. 2022 Oct 26. [Epub ahead of print] PubMed PMID: 36289368
  • Shin JH, Bozadjieva-Kramer N, Shao Y, Lyons-Abbott S, Rupp AC, Sandoval DA, Seeley RJ. The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function. Cell Metab. 2022 Nov 1;34(11):1765-1778.e6. PubMed PMID: 36240758
  • Kim KS, Peck BC, Hung YH, Koch-Laskowski K, Wood L, Dedhia PH, Spence JR, Seeley RJ, Sethupathy P, Sandoval DA. Vertical sleeve gastrectomy induces enteroendocrine cell differentiation of intestinal stem cells through bile acid signaling. JCI Insight. 2022 Jun 8;7(11). PubMed PMID: 35503251
  • Evers SS, Shao Y, Ramakrishnan SK, Shin JH, Bozadjieva-Kramer N, Irmler M, Stemmer K, Sandoval DA, Shah YM, Seeley RJ. Gut HIF2a signaling is increased after VSG, and gut activation of HIF2a decreases weight, improves glucose, and increases GLP-1 secretion. Cell Rep. 2022 Jan 18;38(3):110270. PubMed PMID: 35045308
  • Shao Y, Evers SS, Shin JH, Ramakrishnan SK, Bozadjieva-Kramer N, Yao Q, Shah YM, Sandoval DA, Seeley RJ. Vertical sleeve gastrectomy increases duodenal Lactobacillus spp. richness associated with the activation of intestinal HIF2a signaling and metabolic benefits. Mol Metab. 2022 Mar;57:101432. PubMed PMID: 34998940
  • Bethea M, Sandoval DA. Gut Factors Mediating the Physiological Impact of Bariatric Surgery. Curr Diab Rep. 2022 Aug;22(8):371-383. PubMed PMID: 35723770
  • Bozadjieva-Kramer N, Shin JH, Shao Y, Gutierrez-Aguilar R, Li Z, Heppner KM, Chiang S, Vargo SG, Granger K, Sandoval DA, MacDougald OA, Seeley RJ. Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice. Nat Commun. 2021 Aug 6;12(1):4768. PubMed PMID: 34362888
  • Bethea M, Bozadjieva-Kramer N, Sandoval DA. Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion. Endocrinology. 2021 Oct 1;162(10). PubMed PMID: 34318874
  • Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes Care. 2021 Aug;44(8):1744-1747. PubMed PMID: 34131046
  • de Lima JBM, Debarba LK, Rupp AC, Qi N, Ubah C, Khan M, Didyuk O, Ayyar I, Koch M, Sandoval DA, Sadagurski M. ARC(GHR) Neurons Regulate Muscle Glucose Uptake. Cells. 2021 May 3;10(5). PubMed PMID: 34063647
  • Hutch CR, Stelmak D, Kanke M, Koch-Laskowski K, Cummings B, Griffin C, Leix K, Sethupathy P, Singer K, Sandoval DA. Diet-dependent sex differences in the response to vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2021 Jul 1;321(1):E11-E23. PubMed PMID: 33998293
  • Sandoval D. Updating the Role of a-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. 2020 Nov;69(11):2238-2245. PubMed PMID: 33082272
  • Singha A, Palavicini JP, Pan M, Farmer S, Sandoval D, Han X, Fujikawa T. Leptin Receptors in RIP-Cre(25Mgn) Neurons Mediate Anti-dyslipidemia Effects of Leptin in Insulin-Deficient Mice. Front Endocrinol (Lausanne). 2020;11:588447. PubMed PMID: 33071988
  • Bozadjieva Kramer N, Evers SS, Shin JH, Silverwood S, Wang Y, Burant CF, Sandoval DA, Seeley RJ. The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation. Cell Rep. 2020 Oct 13;33(2):108239. PubMed PMID: 33053352
  • Myronovych A, Bhattacharjee J, Salazar-Gonzalez RM, Tan B, Mowery S, Ferguson D, Ryan KK, Zhang W, Zhao X, Oehrle M, Setchell KD, Seeley RJ, Sandoval DA, Kohli R. Assessment of the role of FGF15 in mediating the metabolic outcomes of murine Vertical Sleeve Gastrectomy (VSG). Am J Physiol Gastrointest Liver Physiol. 2020 Sep 23. [Epub ahead of print] PubMed PMID: 32967428
  • Panaro BL, Yusta B, Matthews D, Koehler JA, Song Y, Sandoval DA, Drucker DJ. Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion. Mol Metab. 2020 Jul;37:100990. PubMed PMID: 32278655
  • Cheng W, Ndoka E, Hutch C, Roelofs K, MacKinnon A, Khoury B, Magrisso J, Kim KS, Rhodes CJ, Olson DP, Seeley RJ, Sandoval D, Myers MG Jr. Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice. JCI Insight. 2020 Apr 9;5(7). PubMed PMID: 32182221
  • Davis EM, Sandoval DA. Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function. Compr Physiol. 2020 Mar 12;10(2):577-595. PubMed PMID: 32163198
  • Flak JN, Goforth PB, Dell'Orco J, Sabatini PV, Li C, Bozadjieva N, Sorensen M, Valenta A, Rupp A, Affinati AH, Cras-Méneur C, Ansari A, Sacksner J, Kodur N, Sandoval DA, Kennedy RT, Olson DP, Myers MG Jr. Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin. J Clin Invest. 2020 Jun 1;130(6):2943-2952. PubMed PMID: 32134398
  • Evers SS, Kim KS, Bozadjieva N, Lewis AG, Farris D, Sorensen MJ, Kim Y, Whitesall SE, Kennedy RT, Michele DE, Seeley RJ, Sandoval DA. Continuous glucose monitoring reveals glycemic variability and hypoglycemia after vertical sleeve gastrectomy in rats. Mol Metab. 2020 Feb;32:148-159. PubMed PMID: 32029224
  • Cheng W, Gonzalez I, Pan W, Tsang AH, Adams J, Ndoka E, Gordian D, Khoury B, Roelofs K, Evers SS, MacKinnon A, Wu S, Frikke-Schmidt H, Flak JN, Trevaskis JL, Rhodes CJ, Fukada SI, Seeley RJ, Sandoval DA, Olson DP, Blouet C, Myers MG Jr. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding. Cell Metab. 2020 Feb 4;31(2):301-312.e5. PubMed PMID: 31955990
  • Alvarez R, Sandoval DA, Seeley RJ. A rodent model of partial intestinal diversion: a novel metabolic operation. Surg Obes Relat Dis. 2020 Feb;16(2):270-281. PubMed PMID: 31874737
  • Framnes-DeBoer SN, Bakke E, Yalamanchili S, Peterson H, Sandoval DA, Seeley RJ, Arble DM. Bromocriptine improves glucose tolerance independent of circadian timing, prolactin, or the melanocortin-4 receptor. Am J Physiol Endocrinol Metab. 2020 Jan 1;318(1):E62-E71. PubMed PMID: 31794265
  • Hutch CR, Trakimas DR, Roelofs K, Pressler J, Sorrell J, Cota D, Obici S, Sandoval DA. Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy. Ann Surg. 2020 Mar;271(3):509-518. PubMed PMID: 30702457
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Department: Pediatrics-Nutrition
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