Jonathan Kurche, MD
Assistant Professor, Medicine-Pulmonary Sciences & Critical Care

Professional Titles

• Assistant Professor

Recognition & Awards

• Fellow, Parker B. Francis Family Foundation (2019)
  "Epithelial biology of the gain-of-function MUC5B promoter risk variant for IPF"

Research Interests

Publications

• Blumhagen RZ, Kurche JS, Cool CD, Walts AD, Heinz D, Fingerlin TE, Yang IV, Schwartz DA. Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis. Respir Res. 2023 Nov 17;24(1):287. PubMed PMID: 37978501
• Dobrinskikh E, Hennessy CE, Kurche JS, Kim E, Estrella AM, Cardwell J, Yang IV, Schwartz DA. Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-associated Lung Fibrosis. Am J Respir Cell Mol Biol. 2023 Jan;68(1):62-74. PubMed PMID: 36108173
• Kurche JS, Stancil IT, Michalski JE, Yang IV, Schwartz DA. Dysregulated Cell-Cell Communication Characterizes Pulmonary Fibrosis. Cells. 2022 Oct 21;11(20). PubMed PMID: 36291184
• Stancil IT, Michalski JE, Hennessy CE, Hatakka KL, Yang IV, Kurche JS, Rincon M, Schwartz DA. Interleukin-6-dependent epithelial fluidization initiates fibrotic lung remodeling. Sci Transl Med. 2022 Jul 20;14(654):eabo5254. PubMed PMID: 35857823
• Ma X, Zhu L, Kurche JS, Xiao H, Dai H, Wang C. Global and regional burden of interstitial lung disease and pulmonary sarcoidosis from 1990 to 2019: results from the Global Burden of Disease study 2019. Thorax. 2022 Jun;77(6):596-605. PubMed PMID: 34556551
• Michalski JE, Kurche JS, Schwartz DA. From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?. Transl Res. 2022 Mar;241:13-24. PubMed PMID: 34547499
• Dobrinskikh E, Estrella AM, Hennessy CE, Hara N, Schwarz MI, Kurche JS, Yang IV, Schwartz DA. Genes, other than Muc5b, play a role in bleomycin-induced lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L440-L450. PubMed PMID: 34160296
• Gally F, Sasse SK, Kurche JS, Gruca MA, Cardwell JH, Okamoto T, Chu HW, Hou X, Poirion OB, Buchanan J, Preissl S, Ren B, Colgan SP, Dowell RD, Yang IV, Schwartz DA, Gerber AN. The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2021 Jan 25;6(2). PubMed PMID: 33320836
• Furusawa H, Cardwell JH, Okamoto T, Walts AD, Konigsberg IR, Kurche JS, Bang TJ, Schwarz MI, Brown KK, Kropski JA, Rojas M, Cool CD, Lee JS, Wolters PJ, Yang IV, Schwartz DA. Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures. Am J Respir Crit Care Med. 2020 Nov 15;202(10):1430-1444. PubMed PMID: 32602730
• Kurche JS, Schwartz DA. Deciphering the Genetics of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2019 Jan 1;199(1):4-5. PMID: 30130126.
• Kurche JS, Dobrinskikh E, Hennessy CE, Huber J, Estrella A, Hancock LA, Schwarz MI, Okamoto T, Cool CD, Yang IV, Evans CM, Schwartz DA. Muc5b Enhances Murine Honeycomb-like Cyst Formation. Am J Respir Cell Mol Biol. 2019 Oct;61(4):544-546. PubMed PMID: 31573335
• Evans CM, Fingerlin TE, Schwarz MI, Lynch D, Kurche J, Warg L, Yang IV, Schwartz DA. Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways. Physiol Rev. 2016 Oct;96(4):1567-91. PubMed PMID: 27630174
• Laub M, Fraser R, Kurche J, Lara A, Kiser TH, Reynolds PM. Use of a Cholestyramine Washout in a Patient With Septic Shock on Leflunomide Therapy: A Case Report and Review of the Literature. J Intensive Care Med. 2016 Jul;31(6):412-4. PubMed PMID: 26446104
• Kelmenson DA, Kurche JS, Geraci M. Spontaneous hemothorax resulting from tissue plasminogen activator in a patient with ischemic stroke and unrecognized recent myocardial infarction. Ann Am Thorac Soc. 2015 Jul;12(7):1105-6. PubMed PMID: 26203614
• Burchill MA, Tamburini BA, Pennock ND, White JT, Kurche JS, Kedl RM. T cell vaccinology: exploring the known unknowns. Vaccine. 2013 Jan 2;31(2):297-305. PubMed PMID: 23137843
• Kurche JS, Haluszczak C, McWilliams JA, Sanchez PJ, Kedl RM. Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression. J Immunol. 2012 Jan 15;188(2):585-93. PubMed PMID: 22156349
• Oh JZ, Kurche JS, Burchill MA, Kedl RM. TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway. Blood. 2011 Sep 15;118(11):3028-38. PubMed PMID: 21813451
• Kurche JS, Burchill MA, Sanchez PJ, Haluszczak C, Kedl RM. Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses. J Immunol. 2010 Aug 15;185(4):2106-15. PubMed PMID: 20639485
• Grazia TJ, Plenter RJ, Doan AN, Kelly BP, Weber SM, Kurche JS, Cushing SO, Gill RG, Pietra BA. Spontaneous allograft tolerance in B7-deficient mice independent of preexisting endogenous CD4+CD25+ regulatory T-cells. Transplantation. 2007 Jun 15;83(11):1449-58. PubMed PMID: 17565318

Professional Memberships

• American Thoracic Society, Member