A. Samy Youssef, MD, PhD, MSc, FAANS
Professor of Clinical Neurosurgery, Neurosurgery

Professional Titles

• Professor of Clinical Otolaryngology
• Director of Complex Cranial and Skull Base Surgery
• Program Director of Skull Base Surgery Fellowship
• Vice Chair of Education

Teaching

Publications

• Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Youssef AS, Lillehei KO, Jensen RL, Graner MW, Ormond DR. High-Throughput Screening of Epigenetic Inhibitors in Meningiomas Identifies HDAC, G9a, and Jumonji-Domain Inhibition as Potential Therapies. J Neurol Surg B Skull Base. 2023 Oct;84(5):452-462. PubMed PMID: 37671294
• Ung TH, Freeman L, Hirt L, Kortz M, Belanger K, Baird-Daniel E, Hosokawa P, Thaker A, Thompson JA, Youssef AS. Surgical outcomes in large vestibular schwannomas: should cerebellopontine edema be considered in the grading systems?. Acta Neurochir (Wien). 2023 Jul;165(7):1749-1755. PubMed PMID: 37204532
• Youssef AS, Schroeder HWS. Indication for a skull base approach in microvascular decompression for hemifacial spasm. Acta Neurochir (Wien). 2022 Dec;164(12):3247-3248. PubMed PMID: 36279011
• Hoffman JE, Wittenberg B, Morel B, Folzenlogen Z, Case D, Roark C, Youssef S, Seinfeld J. Tailored Treatment Options for Cerebral Cavernous Malformations. J Pers Med. 2022 May 20;12(5). PubMed PMID: 35629253
• Labib MA, Zhao X, Houlihan LM, Abramov I, Inoue M, Martinez-Perez R, Catapano JS, Lawton MT, Preul MC, Youssef AS. A two-stage combined anterolateral and endoscopic endonasal approach to the petroclival region: an anatomical study and clinical application. Acta Neurochir (Wien). 2022 Jul;164(7):1899-1910. PubMed PMID: 35416540
• Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Lillehei KO, Jensen RL, Youssef AS, Ormond DR, Graner MW. Targeting DNA Methyl Transferases with Decitabine in Cultured Meningiomas. World Neurosurg. 2022 Jun;162:e99-e119. PubMed PMID: 35248772
• Martinez-Perez R, Kortz MW, Florez-Perdomo W, Ung TH, Youssef AS. Endocrinological outcomes after transcranial resection of tuberculum sellae meningiomas: a systematic review and meta-analysis. Neurosurg Rev. 2022 Jun;45(3):1965-1975. PubMed PMID: 35149901
• Ung TH, Inoue M, Marty E, Ward RC, Martinez-Perez R, Kunigelis KE, Arnone GD, Cass S, Youssef AS. Nervus Intermedius Outcomes After Vestibular Schwannoma Surgery and Radiosurgery: A Single-Institution Experience. World Neurosurg. 2022 Apr;160:e328-e334. PubMed PMID: 35017075
• Martinez-Perez R, Kunigelis KE, Ward RC, Ung TH, Arnone GD, Cass SP, Gubbels SP, Youssef AS. Hydroxyapatite cement cranioplasty for reconstruction of translabyrinthine approach: aesthetic results, long-term satisfaction, quality of life, and complications. Acta Neurochir (Wien). 2022 Mar;164(3):669-677. PubMed PMID: 34642820
• Labib MA, Zhao X, Houlihan LM, Abramov I, Catapano JS, Naeem K, Preul MC, Youssef AS, Lawton MT. Comparative analysis of the combined petrosal and the pretemporal transcavernous anterior petrosal approach to the petroclival region. J Neurosurg. 2022 Mar 1;136(3):905-916. PubMed PMID: 34507299
• Inoue M, Labib M, Yang A, Youssef AS. Recurrent Sphenocavernous Meningioma. J Neurol Surg B Skull Base. 2022 Aug;83(Suppl 3):e610. PubMed PMID: 36068907
• Martinez-Perez R., Youssef AS.: Evolution of the Multidisciplinary Skull Base Team in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Martinez-Perez R., Youssef AS.: The Operating Room, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Martinez-Perez R., Youssef AS.: Cranial Nerve Functional Preservation: Tricks of the Trade, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Martinez-Perez R., Downes AE., Youssef AS.: Neurophysiologic Monitoring, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Youssef AS.: Microdissection Tools, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Reddy VP, Benet A, Labib M, Youssef AS.: The Pretemporal transcavernous Approach, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Folzenlogen Z, Yang A, Youssef AS.: Keyhole Approaches to the Posterior Fossa: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Martinez-Perez R., Downes AE., Youssef AS.: Pineal Tumors, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Martinez-Perez R., Youssef AS.: Anterior Skull Base Meningiomas, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Sethi A, Youssef AS.: Open Surgical Approaches to Meckel’s Cave, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Martinez-Perez R., Youssef AS.: Schwannomas of the Infratemporal Fossa, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Martinez-Perez R., Gubbels S, Youssef AS.: Cholesterol Granulomas and Endolymphatic Sac Tumors, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Labib M., Youssef AS.: The Cavernous Sinus: Surgical Approaches, Open and Endoscopic, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Martinez-Perez R., Youssef AS.: Jugular Foramen Chondrosarcoma, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Cho SS., Labib M., Youssef AS.: Petroclival Meningiomas, in Contemporary Skull base Surgery: A Comprehensive Guide to Functional Preservation. Springer Nature, 2022. ISBN: 978-3-030-99320-7.
• Contemporary Skull Base Surgery: A Comprehensive Guide to Functional Preservation Publisher: Springer Nature Editor: A Samy Youssef ISBN: 978-3-030-99320-7 Published: 7/2022
• Labib MA, Inoue M, Banakis Hartl RM, Cass S, Gubbels S, Lawton MT, Youssef AS. Impact of vestibular nerve preservation on facial and hearing outcomes in small vestibular schwannoma surgery: a technical feasibility study. Acta Neurochir (Wien). 2021 Jan 3. [Epub ahead of print] PubMed PMID: 33389124
• Arnone GD, Kunigelis KE, Gurau A, Coulter I, Thompson J, Youssef AS. Acute Sigmoid Sinus Compromise Following Skull Base Procedures: Is a "Laissez-Faire" Approach Best?. J Neurol Surg B Skull Base. 2021 Dec;82(6):652-658. PubMed PMID: 34745833
• Martinez-Perez R, Kunigelis KE, Ward RC, Ung TH, Arnone GD, Cass SP, Gubbels SP, Youssef AS. Hydroxyapatite cement cranioplasty for reconstruction of translabyrinthine approach: aesthetic results, long-term satisfaction, quality of life, and complications. Acta Neurochir (Wien). 2021 Oct 13. [Epub ahead of print] PubMed PMID: 34642820
• Martinez-Perez R, Aref M, Ramakhrisnan V, Youssef AS. Combined biportal unilateral endoscopic endonasal and endoscopic anterior transmaxillary approach for resection of lesions involving the infratemporal fossa. Acta Neurochir (Wien). 2021 Dec;163(12):3439-3445. PubMed PMID: 34633545
• Labib MA, Zhao X, Houlihan LM, Abramov I, Catapano JS, Naeem K, Preul MC, Youssef AS, Lawton MT. Comparative analysis of the combined petrosal and the pretemporal transcavernous anterior petrosal approach to the petroclival region. J Neurosurg. 2021 Sep 10;:1-12. [Epub ahead of print] PubMed PMID: 34507299
• Kunigelis KE, Kleinschmidt-DeMasters BK, Youssef AS, Lillehei KO, Ormond DR. Clinical Features of Pineal Parenchymal Tumors of Intermediate Differentiation (PPTID): A Single-Institution Series. World Neurosurg. 2021 Nov;155:e229-e235. PubMed PMID: 34418607
• Martinez-Perez R, Florez-Perdomo W, Freeman L, Ung TH, Youssef AS. Long-term disease control and treatment outcomes of stereotactic radiosurgery in cavernous sinus meningiomas. J Neurooncol. 2021 May;152(3):439-449. PubMed PMID: 33772678
• Martinez-Perez R, Ung TH, Youssef AS. The 100 most-cited articles on vestibular schwannoma: historical perspectives, current limitations, and future research directions. Neurosurg Rev. 2021 Dec;44(6):2965-2975. PubMed PMID: 33523339
• Labib MA, Inoue M, Banakis Hartl RM, Cass S, Gubbels S, Lawton MT, Youssef AS. Impact of vestibular nerve preservation on facial and hearing outcomes in small vestibular schwannoma surgery: a technical feasibility study. Acta Neurochir (Wien). 2021 Aug;163(8):2219-2224. PubMed PMID: 33389124
• Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Lillehei K, Youssef AS, Jensen RL, Graner MW, Ormond DR. High-Throughput Mechanistic Screening of Epigenetic Compounds for the Potential Treatment of Meningiomas. J Clin Med. 2021 Jul 16;10(14). PubMed PMID: 34300316
• Youssef AS, Arnone GD, Farell NF, Thompson JA, Ramakrishnan VR, Gubbels S, Cohen-Gadol AA, Cass S, Labib MA. The Combined Endoscopic Endonasal Far Medial and Open Postauricular Transtemporal Approaches As a Lesser Invasive Approach to the Jugular Foramen: Anatomic Morphometric Study With Case Illustration. Oper Neurosurg (Hagerstown). 2020 Sep 15;19(4):471-479. PubMed PMID: 32510567
• Kunigelis KE, Hosokawa P, Arnone G, Raban D, Starr A, Gurau A, Sunshine A, Bunn J, Thaker AA, Youssef AS. The predictive value of preoperative apparent diffusion coefficient (ADC) for facial nerve outcomes after vestibular schwannoma resection: clinical study. Acta Neurochir (Wien). 2020 Aug;162(8):1995-2005. PubMed PMID: 32440924
• Kunigelis KE, Arnone G, Chatain G, Hoffman J, Chatain O, Coulter I, Sunshine A, Lillehei KO, Youssef AS. Defining the timing and role of acute postoperative imaging in pituitary adenoma surgery: clinical study. Acta Neurochir (Wien). 2020 Oct;162(10):2353-2360. PubMed PMID: 32779027
• Labib MA, Belykh E, Cavallo C, Zhao X, Prevedello DM, Carrau RL, Little AS, Ferreira MAT, Preul MC, Youssef AS, Nakaji P. The endoscopic endonasal eustachian tube anterolateral mobilization strategy: minimizing the cost of the extreme-medial approach. J Neurosurg. 2020 Mar 13;:1-12. [Epub ahead of print] PubMed PMID: 32168475
• Cossu G, Jouanneau E, Cavallo LM, Elbabaa SK, Giammattei L, Starnoni D, Barges-Coll J, Cappabianca P, Benes V, Baskaya MK, Bruneau M, Meling T, Schaller K, Chacko AG, Youssef AS, Mazzatenta D, Ammirati M, Dufour H, Laws E, Berhouma M, Daniel RT, Messerer M. Surgical management of craniopharyngiomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section. Acta Neurochir (Wien). 2020 May;162(5):1159-1177. PubMed PMID: 32112169
• Arnone G, Kunigelis K, Gurau A, Coulter I, Thompson J, Youssef AS: Acute sigmoid sinus compromise following skull base procedures: Is a “Laissez-faire” approach best? Accepted for publication. JNLS-B 2020
• Youssef AS, Yang A, Getz AE, Mizuho I, Labib M. Clival Chordoma: Endoscopic Bilateral Transmaxillary Approach. J Neurol Surg B Skull Base. 2019 Dec;80(Suppl 4):S371. PubMed PMID: 31750067
• Vasquez C, Yang A, Youssef AS. Foramen Magnum Meningioma: Far Lateral Approach. J Neurol Surg B Skull Base. 2019 Dec;80(Suppl 4):S363-S364. PubMed PMID: 31750063
• Labib MA, Borba Moreira L, Zhao X, Gandhi S, Cavallo C, Tayebi Meybodi A, Youssef AS, Little AS, Nakaji P, Preul MC, Lawton MT. The side door and front door to the upper retroclival region: a comparative analysis of the open pretemporal and the endoscopic endonasal transcavernous approaches. J Neurosurg. 2019 Nov 8;:1-13. [Epub ahead of print] PubMed PMID: 31703195
• Vasquez CA, Downes A, Kleinschmidt-DeMasters BK, Youssef AS. Functioning Pituitary Adenoma with Xanthogranulomatous Features: Review of Literature and Case Report. J Neurol Surg B Skull Base. 2019 Oct;80(5):449-457. PubMed PMID: 31534885
• Aref M, Kunigelis K, Cass SP, Youssef AS. Retrosigmoid Approach for Vestibular Schwannoma. J Neurol Surg B Skull Base. 2019 Jun;80(Suppl 3):S271. PubMed PMID: 31143585
• Ung TH, Yang A, Aref M, Folzenlogen Z, Ramakrishnan V, Youssef AS. Preservation of olfaction in anterior midline skull base meningiomas: a comprehensive approach. Acta Neurochir (Wien). 2019 Apr;161(4):729-735. PubMed PMID: 30715605
• Farrell NF, Kingdom TT, Getz AE, Lillehei KO, Youssef AS, Ramakrishnan VR. Development of Chronic Sphenoid Sinusitis After Sellar Reconstruction with Medpor Porous Polyethylene Implant. World Neurosurg. 2019 Mar;123:e781-e786. PubMed PMID: 30579017
• Ung TH, Ney DE, Damek D, Rusthoven CG, Youssef AS, Lillehei KO, Ormond DR. The Neurologic Assessment in Neuro-Oncology (NANO) Scale as an Assessment Tool for Survival in Patients With Primary Glioblastoma. Neurosurgery. 2019 Mar 1;84(3):687-695. PubMed PMID: 29618103
• Yang A, Aref M, Youssef AS. Tuberculum Meningioma: Orbitopterional Approach. J Neurol Surg B Skull Base. 2018 Feb;79(2):S219-S220. PubMed PMID: 29404259
• Freeman JL, Sampath R, Quattlebaum SC, Casey MA, Folzenlogen ZA, Ramakrishnan VR, Youssef AS. Expanding the endoscopic transpterygoid corridor to the petroclival region: anatomical study and volumetric comparative analysis. J Neurosurg. 2018 Jun;128(6):1855-1864. PubMed PMID: 28731399
• Oushy S, Sillau SH, Ney DE, Damek DM, Youssef AS, Lillehei KO, Ormond DR. New-onset seizure during and after brain tumor excision: a risk assessment analysis. J Neurosurg. 2018 Jun;128(6):1713-1718. PubMed PMID: 28753117
• Yang A, Aref M, Youssef AS. Tuberculum Meningioma: Orbitopterional Approach. J Neurol Surg B Skull Base. 2018 Feb;79(2):S219-S220. PubMed PMID: 29404259
• Vasquez CA, Thompson JA, Youssef AS. The Tentorial Bridge to Deep Skull Base Exposure: Anatomic Morphometric Study. World Neurosurg. 2018 Jun;114:e588-e596. PubMed PMID: 29551719
• Ung TH, Ney DE, Damek D, Rusthoven CG, Youssef AS, Lillehei KO, Ormond DR. The Neurologic Assessment in Neuro-Oncology (NANO) Scale as an Assessment Tool for Survival in Patients With Primary Glioblastoma. Neurosurgery. 2018 Mar 30. [Epub ahead of print] PubMed PMID: 29618103
• Yang A, Folzenlogen Z, Youssef AS. Minimally invasive endoscopic-assisted approaches to the posterior fossa. J Neurosurg Sci. 2018 Dec;62(6):658-666. PubMed PMID: 29790722
• Aref MH, Youssef AS. Training the skull base surgeon of the future: a comprehensive approach. J Neurosurg Sci. 2018 Dec;62(6):627-635. PubMed PMID: 29790723
• Aref M, Kunigelis KE, Yang A, Subramanian PS, Ramakrishnan VR, Youssef AS. The Effect of Preoperative Direct Ligation of Ethmoidal Arteries on the Perioperative Outcomes of Large Anterior Skull Base Meningiomas Surgery: A Clinical Study. World Neurosurg. 2018 Dec;120:e776-e782. PubMed PMID: 30196172
• Kunigelis KE, Craig D, Yang A, Gubbels S, Youssef AS. Presigmoid Approach to Dumbbell Trigeminal Schwannoma. J Neurol Surg B Skull Base. 2018 Dec;79(Suppl 5):S391-S392. PubMed PMID: 30456036
• Yang A, Kunigelis K, Youssef AS. Retrosigmoid Approach to the Posterior Fossa Trigeminal Schwannoma. J Neurol Surg B Skull Base. 2018 Dec;79(Suppl 5):S393-S394. PubMed PMID: 30456037
• Kunigelis K, Yang A, Youssef AS. Endoscopic Assisted Retrosigmoid Approach for Cerebellopontine Angle Epidermoid Tumor. J Neurol Surg B Skull Base. 2018 Dec;79(Suppl 5):S413-S414. PubMed PMID: 30456046
• Farrell NF, Kingdom TK, Getz AE, Lillehei KO, Youssef AS, Ramakrishnan VR. Development of Chronic Sphenoid Sinusitis After Sellar Reconstruction with Medpor Porous Polyethylene Implant. World Neurosurg. 2018 Dec 19. [Epub ahead of print] PubMed PMID: 30579017
• Oushy S, Sillau SH, Ney DE, Damek DM, Youssef AS, Lillehei KO, Ormond DR. New-onset seizure during and after brain tumor excision: a risk assessment analysis. J Neurosurg. 2017 Jul 28;:1-6. [Epub ahead of print] PubMed PMID: 28753117
• Freeman JL, Sampath R, Quattlebaum SC, Casey MA, Folzenlogen ZA, Ramakrishnan VR, Youssef AS. Expanding the endoscopic transpterygoid corridor to the petroclival region: anatomical study and volumetric comparative analysis. J Neurosurg. 2017 Jul 21;:1-10. [Epub ahead of print] PubMed PMID: 28731399
• Vasquez CA, Casey M, Folzenlogen Z, Ormond DR, Lillehei K, Youssef AS. Third Ventricular Cerebrospinal Fluid Cysts of Thalamic Origin: Review of Embryologic Origin, Presentation, and Management Strategies with a Case Series. World Neurosurg. 2017 Jul;103:210-219. PubMed PMID: 28391023
• Freeman JL, Davern MS, Oushy S, Sillau S, Ormond DR, Youssef AS, Lillehei KO. Spheno-Orbital Meningiomas: A 16-Year Surgical Experience. World Neurosurg. 2017 Mar;99:369-380. PubMed PMID: 28017748
• Freeman JL, Davern MS, Oushy S, Sillau S, Ormond DR, Youssef AS, Lillehei KO. Spheno-Orbital Meningiomas: A 16-Year Surgical Experience. World Neurosurg. 2016 Dec 22. [Epub ahead of print] PubMed PMID: 28017748
• Youssef AS, Sampath R, Freeman JL, Mattingly JK, Ramakrishnan VR. Unilateral endonasal transcribriform approach with septal transposition for olfactory groove meningioma: can olfaction be preserved?. Acta Neurochir (Wien). 2016 Oct;158(10):1965-72. PubMed PMID: 27562683
• Freeman JL, Sampath R, Casey MA, Quattlebaum SC, Ramakrishnan VR, Youssef AS. Transposition of the paraclival carotid artery: a novel concept of self-retaining vascular retraction during endoscopic endonasal skull base surgery technical report. Acta Neurochir (Wien). 2016 Aug;158(8):1625-9. PubMed PMID: 27339269
• Freeman JL, Oushy S, Schowinsky J, Sillau S, Youssef AS. Invasive Giant Cell Tumor of the Lateral Skull Base: A Systematic Review, Meta-Analysis, and Case Illustration. World Neurosurg. 2016 Dec;96:47-57. PubMed PMID: 27269210
• Rusthoven CG, Koshy M, Sher DJ, Ney DE, Gaspar LE, Jones BL, Karam SD, Amini A, Ormond DR, Youssef AS, Kavanagh BD. Combined-Modality Therapy With Radiation and Chemotherapy for Elderly Patients With Glioblastoma in the Temozolomide Era: A National Cancer Database Analysis. JAMA Neurol. 2016 Jul 1;73(7):821-8. PubMed PMID: 27214765
• Rosen SA, Getz AE, Kingdom T, Youssef AS, Ramakrishnan VR. Systematic review of the effectiveness of perioperative prophylactic antibiotics for skull base surgeries. Am J Rhinol Allergy. 2016 Mar-Apr;30(2):e10-6. PubMed PMID: 26980379
• Gompel JJ, Alikhani P, Youssef AS, Loveren HR, Boyev KP, Agazzi S. Anterior Petrosectomy: Consecutive Series of 46 Patients with Attention to Approach-Related Complications. J Neurol Surg B Skull Base. 2015 Sep;76(5):379-84. PubMed PMID: 26401480
• Downes AE, Freeman JL, Ormond DR, Lillehei KO, Youssef AS. Unilateral Tailored Fronto-Orbital Approach for Giant Olfactory Groove Meningiomas: Technical Nuances. World Neurosurg. 2015 Oct;84(4):1166-73. PubMed PMID: 25986205
• Carlson AP, Loveren HR, Youssef AS, Agazzi S. Junctional Internal Carotid Artery Aneurysms: The Schrödinger's Cat of Vascular Neurosurgery. J Neurol Surg B Skull Base. 2015 Mar;76(2):150-6. PubMed PMID: 25844299
• Mizuho Inoue, Mohamed Labib, Alexander Yang, A. Samy Youssef: Recurrent Sphenocavernous Meningioma: Accepted for publication. J Neurol Surg B Skull Base 2020
• Labib M, Zhao X, Houlihan LM, Abramov IT, Catapano JS, Naeem K, Preul MS, Youssef AS, Lawton M: Comparative Analysis of The Combined Petrosal and The Pretemporal Transcavernous Anterior Petrosal Approach to The Petroclival Region: J Neurosurg. JNS 2020.

Professional Memberships

• Congress of Neurological Surgeons (CNS), Member
• American Association of Neurological Surgeons (AANS), Member
• North American Skull Base Society (NASBS), Member
• Mayfield Society, Member