Ryan Aleong, MD

Publications

• Adrenergic Receptor Polymorphisms and Prevention of Ventricular Arrhythmias with Bucindolol in Patients with Chronic Heart Failure. Requested to resubmit to Circulation Arrhythmia after revision.
• Clinical Subtype of Atrial Fibrillation and Heart Failure Outcomes among Veterans with Implantable Defibrillators. Requested to resubmit to the Journal of the American College of Cardiology after revision.
• Abstract 10386: Is New Onset Atrial Fibrillation a Surrogate Marker for Heart Failure Progression? Ryan Aleong, Gordon Davis, William Sauer, Alastair D Robertson, and Michael R Bristow Circulation. 124:A10386,
• Abstract 10438: Prevention of Atrial Fibrillation by Bucindolol is Completely Dependent on the Beta-1 389 Arg/Gly Adrenergic Receptor Polymorphism Ryan Aleong, Gordon Davis, William Sauer, Alastair D Robertson, and Michael R Bristow Circulation. 124:A10438,
• Bristow MR, Aleong RG. Treatment of the heart failure patient with atrial fibrillation: a major unmet need. JACC Heart Fail. 2013 Feb;1(1):29-30. PubMed PMID: 24621796
• Aleong RG, Sauer WH, Davis G, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR. Prevention of Atrial Fibrillation by Bucindolol Is Dependent on the Beta(1)389 Arg/Gly Adrenergic Receptor Polymorphism. JACC Heart Fail. 2013 Aug 1;1(4):338-344. PubMed PMID: 24159564
• Abstract 9250: Endocardial Electrogram Characteristics Indicating an Epicardial Origin of Focal Ventricular Arrhythmias William H Sauer, Wendy Tzou, Joseph L Schuller, Russell Heath, David Katz, Duy T Nguyen, Ryan G Aleong, and Paul D Varosy Circulation. 124:A9250
• A Mobile Tubular Mass Visualized by Transesophageal Echocardiography After Successful Lead Extraction Russell R. Heath, Joseph L. Schuller, William H. Sauer, Paul D. Varosy, Duy T. Nguyen, and Ryan G. Aleong Circulation. 2011;123:e590-e591, doi:10.1161/CIRCULATIONAHA.110.009886
• Olson MD, Phreaner N, Schuller JL, Nguyen DT, Katz DF, Aleong RG, Tzou WS, Sung R, Varosy PD, Sauer WH. Effect of catheter movement and contact during application of radiofrequency energy on ablation lesion characteristics. J Interv Card Electrophysiol. 2013 Nov;38(2):123-9. PubMed PMID: 24022756
• The irregular tachycardia that was not atrial fibrillation. Katz DF, Varosy PD, Nguyen DT, Schuller JL, Aleong RG, Heath RR, Sauer WH. Arch Intern Med. 2011 Dec 12;171(22):1985-8.
• Tzou WS, Nguyen DT, Aleong RG, Varosy PD, Katz DF, Heath RR, Schuller JL, Lowery CM, Lewkowiez L, Sauer WH. Endocardial electrogram characteristics of epicardial ventricular arrhythmias. J Cardiovasc Electrophysiol. 2013 Jun;24(6):649-54. PubMed PMID: 23397974
• Cardiac levels of NOS1AP RNA from right ventricular tissue recovered during lead extraction. Saba S, Mehdi H, Shah H, Islam Z, Aoun E, Termanini S, Mahjoub R, Aleong R, McTiernan CF, London B. Heart Rhythm. 2012 Mar;9(3):399-404. Epub 2011 Oct 19.
• Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure. Circ Arrhythm Electrophysiol. 2013 Feb;6(1):137-43. PubMed PMID: 23275278
• Unusual fibrillation in the emergency department after fall. Zalkind D, Aleong R, Sauer W, Nguyen DT. Circulation. 2011 Jun 28;123(25):e641-2. No abstract available.
• Electrocardiographic characteristics in patients with pulmonary sarcoidosis indicating cardiac involvement. Schuller JL, Olson MD, Zipse MM, Schneider PM, Aleong RG, Wienberger HD, Varosy PD, Sauer WH. J Cardiovasc Electrophysiol. 2011 Nov;22(11):1243-8. doi: 10.1111/j.1540-8167.2011.02099.x. Epub 2011 May 26.
• Kao DP, Davis G, Aleong R, O'Connor CM, Fiuzat M, Carson PE, Anand IS, Plehn JF, Gottlieb SS, Silver MA, Lindenfeld J, Miller AB, White M, Murphy GA, Sauer W, Bristow MR. Effect of bucindolol on heart failure outcomes and heart rate response in patients with reduced ejection fraction heart failure and atrial fibrillation. Eur J Heart Fail. 2013 Mar;15(3):324-33. PubMed PMID: 23223178
• Life-threatening ST-segment elevation without coronary artery disease. Heath RR, Varosy PD, Katz DF, Schuller JL, Aleong RG, Sauer WH, Nguyen DT. Arch Intern Med. 2011 May 9;171(9):801, 802-3.
• Lowery CM, Tzou WS, Aleong RG, Nguyen DT, Varosy PD, Katz DF, Heath RR, Schuller JL, Lewkowiez L, Sauer WH. Use of stored implanted cardiac defibrillator electrograms in catheter ablation of ventricular fibrillation. Pacing Clin Electrophysiol. 2013 Jan;36(1):76-85. PubMed PMID: 23078144
• Treatment of the Heart Failure Patient With Atrial Fibrillation: A Major Unmet Need* Michael R. Bristow, MD, PhD; Ryan G. Aleong, MD; JCHF. 2013;1(1):29-30. doi:10.1016/j.jchf.2012.10.001
• Adrenergic Receptor Polymorphisms and Prevention of Ventricular Arrhythmias with Bucindolol in Patients with Chronic Heart Failure. Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. Circ Arrhythm Electrophysiol. 2012 Dec 30.
• Endocardial Electrogram Characteristics of Epicardial Ventricular Arrhythmias. Tzou WS, Nguyen DT, Aleong RG, Varosy PD, Katz DF, Heath RR, Schuller JL, Lowery CM, Lewkowiez L, Sauer WH. J Cardiovasc Electrophysiol. 2013 Jan 14. doi: 10.1111/jce.12096.
• Use of stored implanted cardiac defibrillator electrograms in catheter ablation of ventricular fibrillation. Lowery CM, Tzou WS, Aleong RG, Nguyen DT, Varosy PD, Katz DF, Heath RR, Schuller JL, Lewkowiez L, Sauer WH. Pacing Clin Electrophysiol. 2013 Jan;36(1):76-85. doi: 10.1111/pace.12019. Epub 2012 Oct 18.
• Katz DF, Turakhia MP, Sauer WH, Tzou WS, Heath RR, Zipse MM, Aleong RG, Varosy PD, Kao DP. Safety of Ventricular Tachycardia Ablation in Clinical Practice: Findings from 9,699 Hospital Discharge Records. Circ Arrhythm Electrophysiol. 2015 Feb 15. [Epub ahead of print] PubMed PMID: 25688143
• Narayanan K, Reinier K, Teodorescu C, Uy-Evanado A, Aleong R, Chugh H, Nichols GA, Gunson K, London B, Jui J, Chugh SS. Left ventricular diameter and risk stratification for sudden cardiac death. J Am Heart Assoc. 2014 Sep 16;3(5):e001193. PubMed PMID: 25227407
• Zipse MM, Sauer WH, Varosy PD, Aleong RG, Nguyen DT. Inappropriate shocks due to subcutaneous air in a patient with a subcutaneous cardiac defibrillator. Circ Arrhythm Electrophysiol. 2014 Aug;7(4):768-70. PubMed PMID: 25140025
• Aleong RG, Sauer WH, Davis G, Bristow MR. New-onset atrial fibrillation predicts heart failure progression. Am J Med. 2014 Oct;127(10):963-71. PubMed PMID: 24931393
• Implantable cardioverter defibrillator therapy in patients with cardiac sarcoidosis. Schuller JL, Zipse M, Crawford T, Bogun F, Beshai J, Patel AR, Sweiss NJ, Nguyen DT, Aleong RG, Varosy PD, Weinberger HD, Sauer WH. J Cardiovasc Electrophysiol. 2012 Sep;23(9):925-9. doi: 10.1111/j.1540-8167.2012.02350.x. Epub 2012 Jul 19.
• Utility of cardiac magnetic resonance imaging to differentiate cardiac sarcoidosis from arrhythmogenic right ventricular cardiomyopathy. Steckman DA, Schneider PM, Schuller JL, Aleong RG, Nguyen DT, Sinagra G, Vitrella G, Brun F, Cova MA, Pagnan L, Mestroni L, Varosy PD, Sauer WH.
• Zipse MM, Aleong RG. Acquired Pulmonary Vein Isolation in a Patient with Friedreich Ataxia. Card Electrophysiol Clin. 2016 Mar;8(1):151-3. PubMed PMID: 26920184
• Effect of bucindolol on heart failure outcomes and heart rate response in patients with reduced ejection fraction heart failure and atrial fibrillation. Kao DP, Davis G, Aleong R, O'Connor CM, Fiuzat M, Carson PE, Anand IS, Plehn JF, Gottlieb SS, Silver MA, Lindenfeld J, Miller AB, White M, Murphy GA, Sauer W, Bristow MR. Eur J Heart Fail. 2012 Dec 7.
• Sandhu A, Krantz MJ, Taylor M, Aleong RG, Stichman J, Schuller JL. Syncope and cardiac arrest during strenuous exercise associated with a novel mutation in LQTS1. Clin Case Rep. 2015 Dec;3(12):971-4. PubMed PMID: 26734131
• Anesthetic management of a surgical patient with cardiac implantable electrical device. Ramachandran S, Janelle G, Aleong R, Berger J, Krumerman A, McKillop M, Weitzel N. Semin Cardiothorac Vasc Anesth. 2012 Sep;16(3):166-75. doi: 10.1177/1089253212453621.
• Aleong RG, Mulvahill MJ, Halder I, Carlson NE, Singh M, Bloom HL, Dudley SC, Ellinor PT, Shalaby A, Weiss R, Gutmann R, Sauer WH, Narayanan K, Chugh SS, Saba S, London B. Left Ventricular Dilatation Increases the Risk of Ventricular Arrhythmias in Patients With Reduced Systolic Function. J Am Heart Assoc. 2015 Jul 31;4(8):e001566. PubMed PMID: 26231842
• Aryana A, Singh SM, Kowalski M, Pujara DK, Cohen AI, Singh SK, Aleong RG, Banker RS, Fuenzalida CE, Prager NA, Bowers MR, D'Avila A, O'Neill PG. Acute and Long-Term Outcomes of Catheter Ablation of Atrial Fibrillation Using the Second-Generation Cryoballoon versus Open-Irrigated Radiofrequency: A Multicenter Experience. J Cardiovasc Electrophysiol. 2015 Aug;26(8):832-9. PubMed PMID: 25917655
• Tachycardia-induced tachycardia. Heath R, Sauer WH, Aleong R, Nguyen DT. J Cardiovasc Electrophysiol. 2012 Dec;23(12):1390-2
• Katz DF, Turakhia MP, Sauer WH, Tzou WS, Heath RR, Zipse MM, Aleong RG, Varosy PD, Kao DP. Safety of ventricular tachycardia ablation in clinical practice: findings from 9699 hospital discharge records. Circ Arrhythm Electrophysiol. 2015 Apr;8(2):362-70. PubMed PMID: 25688143
• Prevention of Atrial Fibrillation by Bucindolol is Dependent on the Beta-1 389 Arg/Gly Adrenergic Receptor Polymorphism Ryan G. Aleong, MD;*,** William H. Sauer, MD;* Gordon Davis, MS;† Guinevere A. Murphy, PhD;† J. David Port, PhD;,†,‡ Inder S. Anand, MD, FACC;§ Mona Fiuzat Pharm D;? Christopher M. O'Connor, MD, FACC;? William T. Abraham, MD, FACC;¶Stephen B. Liggett, MD,# Michael R. Bristow, MD, PhD, FACC†,‡,? Accepted for publication to JACC-Heart Failure
• Impact of payor status on presentation, therapies, and outcomes in 31,614 patients hospitalized with Wolff-Parkinson-White syndrome David P Kao MD, Paul Varosy MD, Ryan Aleong MD Presented at American Heart Association Scientific Sessions 2012
• Brett Oestreich, MD; Bryan Ahlgren, MD; Tames Seres, MD; Matthew M. Zipse, MD; Christine Tompkins, MD; Paul D. Varosy, MD; Ryan G. Aleong, MD. Use of Transesophageal Echocardiography to Improve the Safety of Transvenous Lead Extraction. JACC: Clinical Electrophysiology. 2015; 1(5): 442-448.
• Sri Sundaram, MD; Mam Chandara, MD, William Choe, MD; Ryan G Aleong, MD; Kartik Reddy, MD; T. Jared Bunch, MD. Atrial Fibrillation Ablation performed in the developing world: A description of the first atrial fibrillation ablation performed in Cambodia. Heart Rhythm Case Reports. 2015. 1(5): 360-362.
• William H. Sauer, MD; David A. Steckman, MD; Mathew M. Zipse, MD; Wendy S. Tzou, MD, Ryan G. Aleong, MD. High-power bipolar ablation for incessant ventricular tachycardia utilizing a deep mid-myocardial septal circuit. Heart Rhythm Case Reports. 2015. 1(6): 397-400.
• Single Beat Resetting Response can be used Instead of Entrainment to Identify Proximity to an Arrhythmia Circuit Ryan G. Aleong, MD, Joseph L. Schuller, MD, Russell Heath, MD, Duy T. Nguyen, DM, Paul D. Varosy, MD, William H. Sauer, MD Accepted for presented at American College of Cardiology Scientic Session 2013
• Ryan G. Aleong et al. Risk Score to Predict Adverse Events in 57,220 patients undergoing lead extraction. Presented at Heart Rhythm 2015
• Ryan G. Aleong et al. Analysis of Outcomes of 8,304 patients undergoing lead extraction for Infection. Presented at Heart Rhythm 2015.
• Infra-Hisian Atrioventricular Block. Wendy S. Tzou, Ryan Foley, Duy T. Nguyen and Ryan G. Aleong. Cardiac Electrophysiology Clinics. 2012 Dec; 4(4): 645-649.
• Atrial Oversensing and Mode Switching Caused by Lead Polarization Artifact During an Automatic Ventricular Capture Threshold Test. Russell R. Heath, William H. Sauer, Duy Thai Nguyen, Ryan G. Aleong. Cardiac Electrophysiology Clinics. 2012 Dec; 4(4): 633-636.
• Nguyen DT, Tzou WS, Brunnquell M, Zipse M, Schuller JL, Zheng L, Aleong RA, Sauer WH. Clinical and biophysical evaluation of variable bipolar configurations during radiofrequency ablation for treatment of ventricular arrhythmias. Heart Rhythm. 2016 Nov;13(11):2161-2171. PubMed PMID: 27424078
• Zipse MM, Aleong RG. Acquired Pulmonary Vein Isolation in a Patient with Friedreich Ataxia. Card Electrophysiol Clin. 2016 Mar;8(1):151-3. PubMed PMID: 26920184
• Aleong RG, Sauer WH. Paradox of Appropriate Implantable Cardioverter-Defibrillator Therapy: Saving Lives But Revealing an Increased Mortality Risk. J Am Heart Assoc. 2017 Aug 19;6(8). PubMed PMID: 28862958
• Sandhu A, Borne RT, Mam C, Bunch TJ, Aleong RG. Double jeopardy: long QT3 and Brugada syndromes. Clin Case Rep. 2017 Aug;5(8):1315-1319. PubMed PMID: 28781849
• Heart Block after Discharge in Patients Undergoing TAVR with the Latest Generation Valves. Journal of the American College of Cardiology.
• Sandhu A, Tzou W, Ream K, Valle J, Tompkins C, Nguyen DT, Sauer WH, Carroll JD, Messenger J, Aleong RG. Heart Block After Discharge in Patients Undergoing TAVR With Latest-Generation Valves. J Am Coll Cardiol. 2018 Feb 6;71(5):577-578. PubMed PMID: 29406864
• Piccini JP, Connolly SJ, Abraham WT, Healey JS, Steinberg BA, Al-Khalidi HR, Dignacco P, van Veldhuisen DJ, Sauer WH, White M, Wilton SB, Anand IS, Dufton C, Marshall DA, Aleong RG, Davis GW, Clark RL, Emery LL, Bristow MR. A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial. Am Heart J. 2018 May;199:51-58. PubMed PMID: 29754666
• Tzou WS, Rothstein PA, Cowherd M, Zipse MM, Tompkins C, Marzec L, Aleong RG, Schuller JL, Varosy PD, Borne RT, Mathew J, Tumolo A, Sandhu A, Nguyen DT, Sauer WH. Repeat ablation of refractory ventricular arrhythmias in patients with nonischemic cardiomyopathy: Impact of midmyocardial substrate and role of adjunctive ablation techniques. J Cardiovasc Electrophysiol. 2018 Oct;29(10):1403-1412. PubMed PMID: 30033528
• Sandhu A, Zipse MM, Borne RT, Aleong RG, Tompkins C, Schuller J, Rosenberg M, Varosy PD, Tzou WS, Nguyen DT, Sauer WH. Esophageal position, measured luminal temperatures, and risk of atrioesophageal fistula with atrial fibrillation ablation. Pacing Clin Electrophysiol. 2019 Feb 19. [Epub ahead of print] PubMed PMID: 30779183
• Aleong RG, Zipse MM, Tompkins C, Aftab M, Varosy P, Sauer W, Kao D. Analysis of Outcomes in 8304 Patients Undergoing Lead Extraction for Infection. J Am Heart Assoc. 2020 Apr 7;9(7):e011473. PubMed PMID: 32192410
• Aleong RG, Chang S. Can Ablation for Atrial Fibrillation Be Simpler?: Are Urethral Catheters Unnecessary in Atrial Fibrillation Ablations?. JACC Clin Electrophysiol. 2020 Feb;6(2):191-192. PubMed PMID: 32081222
• Fleeman BE, Aleong RG. Optimal Strategies to Reduce Inappropriate Implantable Cardioverter-defibrillator Shocks. J Innov Card Rhythm Manag. 2019 Apr;10(4):3623-3632. PubMed PMID: 32477727
• Aleong RG, Sandhu A. Does Coffee Reduce the Risk of Atrial Fibrillation?. J Am Heart Assoc. 2019 Aug 6;8(15):e012862. PubMed PMID: 31378125
• Piccini JP, Abraham WT, Dufton C, Carroll IA, Healey JS, van Veldhuisen DJ, Sauer WH, Anand IS, White M, Wilton SB, Aleong R, Rienstra M, Krueger SK, Ayala-Paredes F, Khaykin Y, Merkely B, Miloradovic V, Wranicz JK, Ilkhanoff L, Ziegler PD, Davis G, Emery LL, Marshall D, Kao DP, Bristow MR, Connolly SJ. Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population: The GENETIC-AF Trial. JACC Heart Fail. 2019 Jul;7(7):586-598. PubMed PMID: 31042551
• Sandhu A, Varosy PD, Du C, Aleong RG, Tumolo AZ, West JJ, Tzou WS, Curtis JP, Freeman JV, Friedman DJ, Hess PL. Device-Sizing and Associated Complications With Left Atrial Appendage Occlusion: Findings From the NCDR LAAO Registry. Circ Cardiovasc Interv. 2022 Dec 6;:e012183. [Epub ahead of print] PubMed PMID: 36472194
• Edward JA, Chang SC, Gill EA, Tzou WS, Aleong RG. Esophago-Pericardial Fistula as a Rare and Life-Threatening Complication of Epicardial Ventricular Tachycardia Ablation. JACC Case Rep. 2022 Sep 21;4(18):1180-1185. PubMed PMID: 36213880
• Sabzwari SRA, Rosenberg MA, Mann J, Cerbin L, Barrett C, Garg L, Aleong RG, Sandhu A, West J, Tumolo AZ, Varosy PD, Sauer WH, Zipse MM, Tzou WS. Limitations of Unipolar Signals in Guiding Successful Outflow Tract Premature Ventricular Contraction Ablation. JACC Clin Electrophysiol. 2022 Jul;8(7):843-853. PubMed PMID: 35643806
• Groh WJ, Bhakta D, Tomaselli GF, Aleong RG, Teixeira RA, Amato A, Asirvatham SJ, Cha YM, Corrado D, Duboc D, Goldberger ZD, Horie M, Hornyak JE, Jefferies JL, Kääb S, Kalman JM, Kertesz NJ, Lakdawala NK, Lambiase PD, Lubitz SA, McMillan HJ, McNally EM, Milone M, Namboodiri N, Nazarian S, Patton KK, Russo V, Sacher F, Santangeli P, Shen WK, Sobral Filho DC, Stambler BS, Stöllberger C, Wahbi K, Wehrens XHT, Weiner MM, Wheeler MT, Zeppenfeld K. 2022 HRS expert consensus statement on evaluation and management of arrhythmic risk in neuromuscular disorders. Heart Rhythm. 2022 Oct;19(10):e61-e120. PubMed PMID: 35500790
• Abraham WT, Piccini JP, Dufton C, Carroll IA, Healey JS, O'Connor CM, Marshall D, Aleong R, van Veldhuisen DJ, Rienstra M, Wilton SB, White M, Sauer WH, Anand IS, Huebler SP, Connolly SJ, Bristow MR. Dose-limiting, adverse event-associated bradycardia with ß-blocker treatment of atrial fibrillation in the GENETIC-AF trial. Heart Rhythm O2. 2022 Feb;3(1):40-49. PubMed PMID: 35243434
• Kim RS, Simon S, Powers B, Sandhu A, Sanchez J, Borne RT, Tumolo A, Zipse M, West JJ, Aleong R, Tzou W, Rosenberg MA. Machine Learning Methodologies for Prediction of Rhythm-Control Strategy in Patients Diagnosed With Atrial Fibrillation: Observational, Retrospective, Case-Control Study. JMIR Med Inform. 2021 Dec 6;9(12):e29225. PubMed PMID: 34874889
• Kunkel M, Rothstein P, Sauer P, Zipse MM, Sandhu A, Tumolo AZ, Borne RT, Aleong RG, Cleveland JC Jr, Fullerton D, Pal JD, Davies AS, Lane C, Nguyen DT, Sauer WH, Tzou WS. Open surgical ablation of ventricular tachycardia: Utility and feasibility of contemporary mapping and ablation tools. Heart Rhythm O2. 2021 Jun;2(3):271-279. PubMed PMID: 34337578
• Piccini JP, Dufton C, Carroll IA, Healey JS, Abraham WT, Khaykin Y, Aleong R, Krueger SK, Sauer WH, Wilton SB, Rienstra M, van Veldhuisen DJ, Anand IS, White M, Camm AJ, Ziegler PD, Marshall D, Bristow MR, Connolly SJ. Bucindolol Decreases Atrial Fibrillation Burden in Patients With Heart Failure and the ADRB1 Arg389Arg Genotype. Circ Arrhythm Electrophysiol. 2021 Aug;14(8):e009591. PubMed PMID: 34270905

Specialty Information

• Internal Medicine, Board Certification (2003)
• General Cardiology, Board Certification (2006)
• Cardiology, Board Certification (2006)
• Cardiac Electrophysiology, Board Certification (2008)

• Heart and Circulation - Arrhythmia
• Heart and Circulation - Heart Diseases
• Heart and Circulation