Eric Clambey, PhD

Clambey, E.T., E.N. McNamee, J.A. Westrich, L.E. Glover, E.L. Campbell, P. Jedlicka, E.F. de Zoeten, J. Cambier, K.R. Stenmark, S.P. Colgan and H.K. Eltzschig. "Hypoxia-inducible factor-1 alpha dependent induction of FoxP3 drives regulatory T cell abundance and function during inflammatory hypoxia." Proc Natl Acad Sci USA. 2012 Oct 9;109(41):E2784-93. doi: 10.1073/pnas.1202366109. Epub 2012 Sep 17.

Grenz, A., J.H. Kim, J.D. Bauerle, E. Tak, H.K. Eltzschig, E.T. Clambey. "Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNFa release." J Immunol. 2012 Nov 1; 189(9):4566-73. doi: 10.4049/jimmunol.1201651. Epub 2012 Oct 1.

Collins, B., E.T. Clambey, J. Scott-Browne, J. White, P. Marrack, J. Hagman, J.W. Kappler. "Ikaros promotes rearrangement of TCR alpha genes in an Ikaros null thymoma cell line." Eur J Immunol. 2013 Feb;43(2):521-32. doi: 10.1002/eji.201242757. Epub 2012 Dec 27.

McNamee, E.N., D. Korns Johnson, D. Homann, E.T. Clambey. "Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation and function." Immunol Res. 2013 Mar;55(1-3):58-70. doi: 10.1007/s12026-012-8349-8.

Ehrentraut, H., E.T. Clambey, E.N. McNamee, K.S. Brodsky, S.F. Ehrentraut, J.M. Poth, A.K. Riegel, J.A. Westrich, S.P. Colgan, H.K. Eltzschig. "CD73+ Regulatory T Cells Contribute to Adenosine-Mediated Resolution of Acute Lung Injury." FASEB J, 2013 Feb 14. [Epub ahead of print]

Clambey ET, Collins B, Young MH, Eberlein J, David A, Kappler JW, Marrack P. "The Ikaros Transcription Factor Regulates Responsiveness to IL-12 and Expression of IL-2 Receptor Alpha in Mature, Activated CD8 T Cells." PLoS ONE. 2013: 8(2): e57435. doi:10.1371/journal.pone.0057435

Bartels K, Karhausen J, Clambey ET, Grenz A, Eltzschig HK. Perioperative organ injury. Anesthesiology. 2013 Dec;119(6):1474-89. PubMed PMID: 24126264

Tak E, Ridyard D, Badulak A, Giebler A, Shabeka U, Werner T, Clambey E, Moldovan R, Zimmerman MA, Eltzschig HK, Grenz A. Protective role for netrin-1 during diabetic nephropathy. J Mol Med (Berl). 2013 Sep;91(9):1071-80. PubMed PMID: 23636509

Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun. 2014 Aug 19;5:4674. PubMed PMID: 25135627

Clambey ET, Collins B, Young MH, Eberlein J, David A, Kappler JW, Marrack P. The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells. PLoS One. 2013;8(2):e57435. PubMed PMID: 23483882

Clambey ET, Davenport B, Kappler JW, Marrack P, Homann D. Molecules in medicine mini review: the aß T cell receptor. J Mol Med (Berl). 2014 Jul;92(7):735-41. PubMed PMID: 24848996

"Gammaherpesvirus Small Noncoding RNAs Are Bifunctional Elements That Regulate Infection and Contribute to Virulence In Vivo." Kevin W. Diebel, Lauren M. Oko, Eva M. Medina, Brian F. Niemeyer, Cody J. Warren, David J. Claypool, Scott A. Tibbetts, Carlyne D. Cool, Eric T. Clambey, Linda F. van Dyk. mBio, in press, Dec 28, 2014.

Ehrentraut H, Clambey ET, McNamee EN, Brodsky KS, Ehrentraut SF, Poth JM, Riegel AK, Westrich JA, Colgan SP, Eltzschig HK. CD73 regulatory T cells contribute to adenosine-mediated resolution of acute lung injury. FASEB J. 2013 Jun;27(6):2207-19. PubMed PMID: 23413361

Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec 1;125(12):4666-80. PubMed PMID: 26551682

Collins B, Clambey ET, Scott-Browne J, White J, Marrack P, Hagman J, Kappler JW. Ikaros promotes rearrangement of TCR a genes in an Ikaros null thymoma cell line. Eur J Immunol. 2013 Feb;43(2):521-32. PubMed PMID: 23172374

Victorino F, Sojka DK, Brodsky KS, McNamee EN, Masterson JC, Homann D, Yokoyama WM, Eltzschig HK, Clambey ET. Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody. J Immunol. 2015 Nov 15;195(10):4973-85. PubMed PMID: 26453755

Williams LM, Niemeyer BF, Franklin DS, Clambey ET, van Dyk LF. A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency. J Virol. 2015 Nov;89(21):10821-31. PubMed PMID: 26292318

McNamee EN, Korns Johnson D, Homann D, Clambey ET. Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function. Immunol Res. 2013 Mar;55(1-3):58-70. PubMed PMID: 22961658

Diebel KW, Oko LM, Medina EM, Niemeyer BF, Warren CJ, Claypool DJ, Tibbetts SA, Cool CD, Clambey ET, van Dyk LF. Gammaherpesvirus small noncoding RNAs are bifunctional elements that regulate infection and contribute to virulence in vivo. MBio. 2015 Feb 17;6(1):e01670-14. PubMed PMID: 25691585

Nelsen MK, Beard KS, Plenter RJ, Kedl RM, Clambey ET, Gill RG. Disruption of Transplant Tolerance by an 'Incognito' Form of CD8( ) T Cell-Dependent Memory. Am J Transplant. 2017 Jan 9. [Epub ahead of print] PubMed PMID: 28066981

Eberlein J, Davenport B, Nguyen T, Victorino F, Haist K, Jhun K, Karimpour-Fard A, Hunter L, Kedl R, Clambey ET, Homann D. Aging promotes acquisition of naive-like CD8 memory T cell traits and enhanced functionalities. J Clin Invest. 2016 Oct 3;126(10):3942-3960. PubMed PMID: 27617858

Bartek IL, Reichlen MJ, Honaker RW, Leistikow RL, Clambey ET, Scobey MS, Hinds AB, Born SE, Covey CR, Schurr MJ, Lenaerts AJ, Voskuil MI. Antibiotic Bactericidal Activity Is Countered by Maintaining pH Homeostasis in Mycobacterium smegmatis. mSphere. 2016 Aug 24;1(4). PubMed PMID: 27579369

Cicchini L, Westrich JA, Xu T, Vermeer DW, Berger JN, Clambey ET, Lee D, Song JI, Lambert PF, Greer RO, Lee JH, Pyeon D. Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14. MBio. 2016 May 3;7(3). PubMed PMID: 27143385

Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017;6(10):e1356153. PubMed PMID: 29123967

Abbate LM, Perman SM, Ginde AA, Clambey ET, Van Pelt RE. Age Modifies the Association Between Obesity and Mortality in Individuals Hospitalized with Severe Sepsis. J Am Geriatr Soc. 2016 Apr;64(4):882-3. PubMed PMID: 27100585

Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris J, Clambey ET, Thurman JM, Nemenoff RA. Complement activation via a C3a receptor pathway alters CD4 T lymphocytes and mediates lung cancer progression. Cancer Res. 2017 Nov 8. [Epub ahead of print] PubMed PMID: 29118090

Clambey, E.T. L.F. van Dyk. “Multifaceted Roles of the Viral Cyclin in Gammaherpesvirus Pathogenesis.” Current Clinical Microbiology Reports, September 2016, Volume 3, Issue 3, pp 162–169, DOI 10.1007/s40588-016-0042-6

Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20;9(408). PubMed PMID: 28931657

Li, H.Y., M. McSharry, B. Bullock, T.T. Nguyen, J. Kwak, J.M. Poczobutt, T.R. Sippel, M.C. Weiser-Evans, E.T. Clambey, and R.A. Nemenoff. "Sensitivity of K-Ras Mutant Lung Tumors to PD-1/PD-L1 Antibody Blockade is Dependent on the Appropriate Tumor Microenvironment in Syngeneic Mouse Models." UNDER REVIEW, Clinical Cancer Research

Li HY, McSharry M, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC, Clambey ET, Nemenoff RA. The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade. Cancer Immunol Res. 2017 Sep;5(9):767-777. PubMed PMID: 28819064

Nelsen MK, Beard KS, Plenter RJ, Kedl RM, Clambey ET, Gill RG. Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory. Am J Transplant. 2017 Jul;17(7):1742-1753. PubMed PMID: 28066981

Kimball, A.K., L.M. Oko, B.L. Bullock, R.A. Nemenoff, L.F. van Dyk, E.T. Clambey. "A Beginner’s Guide To Analyzing and Visualizing Mass Cytometry Data." Journal of Immunology, in press with anticipated publication January 1, 2018.

Niemeyer, B., L.M. Oko, E. Medina, D. Oldenburg, D. White, C. Cool, E.T. Clambey, and L.F. van Dyk. “Host Tumor Suppressor p18INK4c functions as a potent cell-intrinsic inhibitor of ?HV68 reactivation and pathogenesis.” J Virology, in press.

Bennett Davenport, Jens Eberlein, Verena van der Heide, Kevin Jhun, Tom Nguyen, Francisco Victorino, Andrew Trotta, Jerry Chipuk, Zhengzi Yi, Weijia Zhang, Eric Clambey, Donald K Scott, Dirk Homann. "Aging Of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations And Lymphoid Tissue Homing."

Kleczko EK, Marsh KH, Tyler LC, Furgeson SB, Bullock BL, Altmann CJ, Miyazaki M, Gitomer BY, Harris PC, Weiser-Evans MCM, Chonchol MB, Clambey ET, Nemenoff RA, Hopp K. CD8( ) T cells modulate autosomal dominant polycystic kidney disease progression. Kidney Int. 2018 Sep 17. [Epub ahead of print] PubMed PMID: 30249452

Kwak, J.W., J. Laskowski, H. Li, M. McSharry, T. Sippel, B. Bullock, A.J. Johnson, J.M. Poczobutt, A. Neuwelt, S. Malkoski, M. Weiser-Evans, J.D. Lambris, E.T. Clambey, J.M. Thurman, R.A. Nemenoff. "Complement Activation Mediates Lung Cancer Progression Through a C3a Receptor Pathway Resulting in Alterations in CD4+ T Lymphocytes." UNDER REVIEW, Clinical Cancer Research

Oweida A, Hararah MK, Phan A, Binder D, Bhatia S, Lennon S, Bukkapatnam S, Van Court B, Uyanga N, Darragh L, Kim HM, Raben D, Tan AC, Heasley L, Clambey E, Nemenoff R, Karam SD. Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration. Clin Cancer Res. 2018 Nov 1;24(21):5368-5380. PubMed PMID: 30042205

Li HY, McSharry M, Walker D, Johnson A, Kwak J, Bullock B, Neuwelt A, Poczobutt JM, Sippel TR, Keith RL, Weiser-Evans MCM, Clambey E, Nemenoff RA. Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4 T lymphocytes in tumors that express MHC class II. Oncoimmunology. 2018;7(5):e1423182. PubMed PMID: 29721380

Neudecker, N., K.S. Brodsky, E.T. Clambey, E.P. Schmidt, T.A. Packard, B. Davenport, T.J. Standiford, T. Weng, A.A. Fletcher, L. Barthel, J.C. Masterson, G.T. Furuta, M.R. Blackburn, A.A. Ginde, W.J. Janssen, R.L. Zemans, C.M. Evans, E.L. Burnham, D. Homann, M. Moss, S. Kreth, K. Zacharowski, P.M. Henson and H.K. Eltzschig. "Neutrophil-epithelial miR-223 shuttling dampens acute lung injury." IN REVISION, Science Translational Medicine.

Oko, L.M., A.K. Kimball, T. Chang, B. Alderete, L.F. van Dyk, E.T. Clambey. "Characterizing virus infection heterogeneity by simultaneous measurement of RNA expression and degradation", UNDER REVIEW, Nature Methods

Mahalingam R, Kaufer BB, Ouwendijk WJD, Verjans GMGM, Coleman C, Hunter M, Das A, Palmer BE, Clambey E, Nagel MA, Traina-Dorge V. Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques. J Virol. 2018 Apr 1;92(7). PubMed PMID: 29343566

Niemeyer BF, Oko LM, Medina EM, Oldenburg DG, White DW, Cool CD, Clambey ET, van Dyk LF. Host Tumor Suppressor p18(INK4c) Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis. J Virol. 2018 Mar 15;92(6). PubMed PMID: 29298882

Kimball AK, Oko LM, Bullock BL, Nemenoff RA, van Dyk LF, Clambey ET. A Beginner's Guide to Analyzing and Visualizing Mass Cytometry Data. J Immunol. 2018 Jan 1;200(1):3-22. PubMed PMID: 29255085

Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017;6(10):e1356153. PubMed PMID: 29123967

Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4( ) T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 1;78(1):143-156. PubMed PMID: 29118090

Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20;9(408). PubMed PMID: 28931657

Li HY, McSharry M, Bullock B, Nguyen TT, Kwak J, Poczobutt JM, Sippel TR, Heasley LE, Weiser-Evans MC, Clambey ET, Nemenoff RA. The Tumor Microenvironment Regulates Sensitivity of Murine Lung Tumors to PD-1/PD-L1 Antibody Blockade. Cancer Immunol Res. 2017 Sep;5(9):767-777. PubMed PMID: 28819064

Nelsen MK, Beard KS, Plenter RJ, Kedl RM, Clambey ET, Gill RG. Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory. Am J Transplant. 2017 Jul;17(7):1742-1753. PubMed PMID: 28066981

Karuppuchamy T, Tyler CJ, Lundborg LR, Pérez-Jeldres T, Kimball AK, Clambey ET, Jedlicka P, Rivera-Nieves J. Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn's-Like Ileitis by Suppressing Thymocyte Maturation. Inflamm Bowel Dis. 2020 Jan 6;26(2):216-228. PubMed PMID: 31807751

Kimball AK, Oko LM, Kaspar RE, van Dyk LF, Clambey ET. High-Dimensional Characterization of IL-10 Production and IL-10-Dependent Regulation during Primary Gammaherpesvirus Infection. Immunohorizons. 2019 Mar 21;3(3):94-109. PubMed PMID: 31356152

Oweida AJ, Mueller AC, Piper M, Milner D, Van Court B, Bhatia S, Phan A, Bickett T, Jordan K, Proia T, Schulick R, Messersmith WA, Del Chiaro M, Clambey E, Gough MJ, Williams J, Hansen K, Goodman K, Karam SD. Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide. Cancer Immunol Immunother. 2020 Oct 23. [Epub ahead of print] PubMed PMID: 33097963

Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2020 Sep 15. [Epub ahead of print] PubMed PMID: 32931017

Oko LM, Kimball AK, Kaspar RE, Knox AN, Coleman CB, Rochford R, Chang T, Alderete B, van Dyk LF, Clambey ET. Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression. PLoS Pathog. 2019 Jun;15(6):e1007849. PubMed PMID: 31166996

Laskowski J, Renner B, Pickering MC, Serkova NJ, Smith-Jones PM, Clambey ET, Nemenoff RA, Thurman JM. Complement factor H-deficient mice develop spontaneous hepatic tumors. J Clin Invest. 2020 Aug 3;130(8):4039-4054. PubMed PMID: 32369457

Bullock BL, Kimball AK, Poczobutt JM, Neuwelt AJ, Li HY, Johnson AM, Kwak JW, Kleczko EK, Kaspar RE, Wagner EK, Hopp K, Schenk EL, Weiser-Evans MC, Clambey ET, Nemenoff RA. Tumor-intrinsic response to IFN? shapes the tumor microenvironment and anti-PD-1 response in NSCLC. Life Sci Alliance. 2019 Jun;2(3). PubMed PMID: 31133614

Neuwelt AJ, Kimball AK, Johnson AM, Arnold BW, Bullock BL, Kaspar RE, Kleczko EK, Kwak JW, Wu MH, Heasley LE, Doebele RC, Li HY, Nemenoff RA, Clambey ET. Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms. J Immunother Cancer. 2020 Apr;8(1). PubMed PMID: 32312906

Johnson AM, Bullock BL, Neuwelt AJ, Poczobutt JM, Kaspar RE, Li HY, Kwak JW, Hopp K, Weiser-Evans MCM, Heasley LE, Schenk EL, Clambey ET, Nemenoff RA. Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma. J Immunol. 2020 Apr 15;204(8):2295-2307. PubMed PMID: 32179637

Borgers JSW, Tobin RP, Vorwald VM, Smith JM, Davis DM, Kimball AK, Clambey ET, Couts KL, McWilliams JA, Jordan KR, Torphy RJ, Schulick R, McCarter MD. High-Dimensional Analysis of Postsplenectomy Peripheral Immune Cell Changes. Immunohorizons. 2020 Feb 18;4(2):82-92. PubMed PMID: 32071067

Karuppuchamy T, Tyler CJ, Lundborg LR, Pérez-Jeldres T, Kimball AK, Clambey ET, Jedlicka P, Rivera-Nieves J. Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn's-Like Ileitis by Suppressing Thymocyte Maturation. Inflamm Bowel Dis. 2020 Jan 6;26(2):216-228. PubMed PMID: 31807751

Kimball AK, Oko LM, Kaspar RE, van Dyk LF, Clambey ET. High-Dimensional Characterization of IL-10 Production and IL-10-Dependent Regulation during Primary Gammaherpesvirus Infection. Immunohorizons. 2019 Mar 21;3(3):94-109. PubMed PMID: 31356152

Oko LM, Kimball AK, Kaspar RE, Knox AN, Coleman CB, Rochford R, Chang T, Alderete B, van Dyk LF, Clambey ET. Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression. PLoS Pathog. 2019 Jun;15(6):e1007849. PubMed PMID: 31166996

Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D, Serkova NJ, Wang XJ, Jimeno A, Clambey ET, Pasquale EB, Karam SD. Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers. Cancer Res. 2019 May 15;79(10):2722-2735. PubMed PMID: 30894369

Bullock BL, Kimball AK, Poczobutt JM, Neuwelt AJ, Li HY, Johnson AM, Kwak JW, Kleczko EK, Kaspar RE, Wagner EK, Hopp K, Schenk EL, Weiser-Evans MC, Clambey ET, Nemenoff RA. Tumor-intrinsic response to IFN? shapes the tumor microenvironment and anti-PD-1 response in NSCLC. Life Sci Alliance. 2019 Jun;2(3). PubMed PMID: 31133614

Oweida AJ, Darragh L, Phan A, Binder D, Bhatia S, Mueller A, Court BV, Milner D, Raben D, Woessner R, Heasley L, Nemenoff R, Clambey E, Karam SD. STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. J Natl Cancer Inst. 2019 Dec 1;111(12):1339-1349. PubMed PMID: 30863843

Tu MM, Lee FYF, Jones RT, Kimball AK, Saravia E, Graziano RF, Coleman B, Menard K, Yan J, Michaud E, Chang H, Abdel-Hafiz HA, Rozhok AI, Duex JE, Agarwal N, Chauca-Diaz A, Johnson LK, Ng TL, Cambier JC, Clambey ET, Costello JC, Korman AJ, Theodorescu D. Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy. Sci Adv. 2019 Feb;5(2):eaav2437. PubMed PMID: 30801016

Davenport B, Eberlein J, van der Heide V, Jhun K, Nguyen TT, Victorino F, Trotta A, Chipuk J, Yi Z, Zhang W, Clambey ET, Scott DK, Homann D. Aging of Antiviral CD8( ) Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing. J Immunol. 2019 Jan 15;202(2):460-475. PubMed PMID: 30552164

Ashley N. Knox, Alice Mueller, Eva M. Medina, Eric T. Clambey, Linda F. van Dyk. Lytic infection with murine gammaherpesvirus 68 activates host and viral RNA polymerase III-dependent promoters to enhance non-coding RNA expression. bioRxiv 795278; doi: https://doi.org/10.1101/795278

Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D, Serkova NJ, Wang XJ, Jimeno A, Clambey ET, Pasquale EB, Karam SD. Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers. Cancer Res. 2019 May 15;79(10):2722-2735. PubMed PMID: 30894369

Oweida AJ, Darragh L, Phan A, Binder D, Bhatia S, Mueller A, Court BV, Milner D, Raben D, Woessner R, Heasley L, Nemenoff R, Clambey E, Karam SD. STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. J Natl Cancer Inst. 2019 Dec 1;111(12):1339-1349. PubMed PMID: 30863843

Tu MM, Lee FYF, Jones RT, Kimball AK, Saravia E, Graziano RF, Coleman B, Menard K, Yan J, Michaud E, Chang H, Abdel-Hafiz HA, Rozhok AI, Duex JE, Agarwal N, Chauca-Diaz A, Johnson LK, Ng TL, Cambier JC, Clambey ET, Costello JC, Korman AJ, Theodorescu D. Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy. Sci Adv. 2019 Feb;5(2):eaav2437. PubMed PMID: 30801016

Brian F Niemeyer, Joy E Gibson, Jennifer N Berger, Lauren M Oko, Eva Medina, Eric T Clambey, Linda F van Dyk. The gammaherpesvirus 68 viral cyclin facilitates reactivation by promoting latent gene expression. bioRxiv 761700; doi: https://doi.org/10.1101/761700

Davenport B, Eberlein J, van der Heide V, Jhun K, Nguyen TT, Victorino F, Trotta A, Chipuk J, Yi Z, Zhang W, Clambey ET, Scott DK, Homann D. Aging of Antiviral CD8( ) Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing. J Immunol. 2019 Jan 15;202(2):460-475. PubMed PMID: 30552164

Brian F Niemeyer, Joy E Gibson, Jennifer N Berger, Lauren M Oko, Eva Medina, Eric T Clambey, Linda F van Dyk. The gammaherpesvirus 68 viral cyclin facilitates reactivation by promoting latent gene expression. bioRxiv 761700; doi: https://doi.org/10.1101/761700

Ashley N. Knox, Alice Mueller, Eva M. Medina, Eric T. Clambey, Linda F. van Dyk. Lytic infection with murine gammaherpesvirus 68 activates host and viral RNA polymerase III-dependent promoters to enhance non-coding RNA expression. bioRxiv 795278; doi: https://doi.org/10.1101/795278

Jennifer N. Berger, Bridget Sanford, Abigail K. Kimball, Lauren M. Oko, Rachael E. Kaspar, Brian F. Niemeyer, Kenneth L. Jones, Eric T. Clambey, Linda F. van Dyk. Redefining De Novo Gammaherpesvirus Infection Through High-Dimensional, Single-Cell Analysis of Virus and Host. bioRxiv 2020.08.11.203117; doi: https://doi.org/10.1101/2020.08.11.203117

Julianne B. Riggs, Eva M. Medina, Loni J. Perrenoud, Diana L. Bonilla, Eric T. Clambey, Linda F. van Dyk, Leslie J. Berg. Optimized detection of acute MHV68 infection with a reporter system identifies large peritoneal macrophages as a dominant target of primary infection. bioRxiv 2020.11.17.387969; doi: https://doi.org/10.1101/2020.11.17.387969

Bickett TE, Knitz M, Darragh LB, Bhatia S, Van Court B, Gadwa J, Bhuvane S, Piper M, Nguyen D, Tu H, Lenz L, Clambey ET, Barry K, Karam SD. FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC. Clin Cancer Res. 2021 Sep 13. [Epub ahead of print] PubMed PMID: 34518311

Johnson AM, Boland JM, Wrobel J, Klezcko EK, Weiser-Evans M, Hopp K, Heasley L, Clambey ET, Jordan K, Nemenoff RA, Schenk EL. Cancer Cell-Specific Major Histocompatibility Complex II Expression as a Determinant of the Immune Infiltrate Organization and Function in the NSCLC Tumor Microenvironment. J Thorac Oncol. 2021 Oct;16(10):1694-1704. PubMed PMID: 34048945

Knox AN, Mueller A, Medina EM, Clambey ET, van Dyk LF. Lytic Infection with Murine Gammaherpesvirus 68 Activates Host and Viral RNA Polymerase III Promoters and Enhances Noncoding RNA Expression. J Virol. 2021 Jun 24;95(14):e0007921. PubMed PMID: 33910955

Knitz MW, Bickett TE, Darragh LB, Oweida AJ, Bhatia S, Van Court B, Bhuvane S, Piper M, Gadwa J, Mueller AC, Nguyen D, Nangia V, Osborne DG, Bai X, Ferrara SE, Boss MK, Goodspeed A, Burchill MA, Tamburini BAJ, Chan ED, Pickering CR, Clambey ET, Karam SD. Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis. J Immunother Cancer. 2021 Apr;9(4). PubMed PMID: 33883256

Riggs JB, Medina EM, Perrenoud LJ, Bonilla DL, Clambey ET, van Dyk LF, Berg LJ. Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection. Front Microbiol. 2021;12:656979. PubMed PMID: 33767688

Korpela SP, Hinz TK, Oweida A, Kim J, Calhoun J, Ferris R, Nemenoff RA, Karam SD, Clambey ET, Heasley LE. Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. J Transl Med. 2021 Jan 23;19(1):43. PubMed PMID: 33485341

Oweida AJ, Mueller AC, Piper M, Milner D, Van Court B, Bhatia S, Phan A, Bickett T, Jordan K, Proia T, Schulick R, Messersmith WA, Del Chiaro M, Clambey E, Gough MJ, Williams J, Hansen K, Goodman K, Karam SD. Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide. Cancer Immunol Immunother. 2021 Apr;70(4):989-1000. PubMed PMID: 33097963

Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2021 Jan;162(1):68-83. PubMed PMID: 32931017

NPEPPS regulates intracellular import and sensitivity to cisplatin by interaction with volume regulated anion channels Robert T. Jones, Andrew Goodspeed, Maryam C. Akbarzadeh, Mathijs Scholtes, Hedvig Vekony, Annie Jean, Charlene B. Tilton, Saswat Mohapatra, Michael V. Orman, Stephanie Araki, Molishree Joshi, Mahmood Javaid, Eric T. Clambey, Ryan Layer, Teemu D. Laajala, Sarah Parker, Tokameh Mahmoudi, Tahlita Zuiverloon, Dan Theodorescu, James C. Costello. bioRxiv 2021.03.04.433676; doi: https://doi.org/10.1101/2021.03.04.433676

Redefining De Novo Gammaherpesvirus Infection Through High-Dimensional, Single-Cell Analysis of Virus and Host Jennifer N. Berger, Bridget Sanford, Abigail K. Kimball, Lauren M. Oko, Rachael E. Kaspar, Brian F. Niemeyer, Kenneth L. Jones, Eric T. Clambey, Linda F. van Dyk bioRxiv 2020.08.11.203117; doi: https://doi.org/10.1101/2020.08.11.203117

"The gammaherpesvirus 68 viral cyclin facilitates reactivation by promoting latent gene expression." Brian F Niemeyer, Joy E Gibson, Jennifer N Berger, Lauren M Oko, Eva Medina, Eric T Clambey, Linda F van Dyk. bioRxiv 761700; doi: https://doi.org/10.1101/761700

Niemeyer BF, Sanford B, Gibson JE, Berger JN, Oko LM, Medina E, Clambey ET, van Dyk LF. The gammaherpesvirus 68 viral cyclin facilitates expression of LANA. PLoS Pathog. 2021 Nov;17(11):e1010019. PubMed PMID: 34780571

Bickett TE, Knitz M, Darragh LB, Bhatia S, Van Court B, Gadwa J, Bhuvane S, Piper M, Nguyen D, Tu H, Lenz L, Clambey ET, Barry K, Karam SD. FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC. Clin Cancer Res. 2021 Nov 15;27(22):6235-6249. PubMed PMID: 34518311

Johnson AM, Boland JM, Wrobel J, Klezcko EK, Weiser-Evans M, Hopp K, Heasley L, Clambey ET, Jordan K, Nemenoff RA, Schenk EL. Cancer Cell-Specific Major Histocompatibility Complex II Expression as a Determinant of the Immune Infiltrate Organization and Function in the NSCLC Tumor Microenvironment. J Thorac Oncol. 2021 Oct;16(10):1694-1704. PubMed PMID: 34048945

Redefining De Novo Gammaherpesvirus Infection Through High-Dimensional, Single-Cell Analysis of Virus and Host. Jennifer N. Berger, Bridget Sanford, Abigail K. Kimball, Lauren M. Oko, Rachael E. Kaspar, Brian F. Niemeyer, Kenneth L. Jones, Eric T. Clambey, Linda F. van Dyk. bioRxiv 2020.08.11.203117; doi: https://doi.org/10.1101/2020.08.11.203117

Gammaherpesvirus ncRNAs share conserved features of binding and virulence despite lack of sequence conservation. Ashley N. Knox, Eva M. Medina, Darby G. Oldenburg, Eric T. Clambey, Linda F. van Dyk. bioRxiv 2022.05.09.491269; doi: https://doi.org/10.1101/2022.05.09.491269

The Tryptophan Metabolizing Enzyme Indoleamine 2,3-Dioxygenase 1 Regulates Polycystic Kidney Disease Progression. Dustin T. Nguyen, Emily K. Kleczko, Nidhi Dwivedi, Berenice Y. Gitomer, Michel B. Chonchol, Eric T. Clambey, Raphael A. Nemenoff, Jelena Klawitter, Katharina Hopp. bioRxiv 2022.05.04.490641; doi: https://doi.org/10.1101/2022.05.04.490641

NPEPPS regulates intracellular import and sensitivity to cisplatin by interaction with volume-regulated anion channels. Robert T. Jones, Andrew Goodspeed, Saswat Mohapatra, Lily Elizabeth Feldman, Mathijs Scholtes, Hedvig Vekony, Annie Jean, Charlene B. Tilton, Michael V. Orman, Cailin Deiter, Nathaniel Xander, Stephanie Araki, Molishree Joshi, Mahmood Javaid, Eric T. Clambey, Ryan Layer, Teemu D. Laajala, Sarah Parker, Tahlita Zuiverloon, Dan Theodorescu, James C. Costello. bioRxiv 2021.03.04.433676; doi: https://doi.org/10.1101/2021.03.04.433676

Immune Checkpoint Activity Regulates Polycystic Kidney Disease Progression. Emily K. Kleczko, Dustin T. Nguyen, Kenneth H. Marsh, Colin D. Bauer, Amy S. Li, Seth B. Furgeson, Berenice Y. Gitomer, Michel B. Chonchol, Eric T. Clambey, Kurt A. Zimmerman, Raphael A. Nemenoff, Katharina Hopp. bioRxiv 2022.04.24.489306; doi: https://doi.org/10.1101/2022.04.24.489306

Adaptive immunity is required for durable responses to alectinib in murine models of EML4-ALK lung cancer. Emily K. Kleczko, Trista K. Hinz, Teresa T. Nguyen, Natalia J. Gurule, Andre Navarro, Anh T. Le, Amber M. Johnson, Jeff Kwak, Diana I. Polhac, Eric T. Clambey, Mary Weiser-Evans, Tejas Patil, Erin L. Schenk, Lynn E. Heasley, Raphael A. Nemenoff. bioRxiv 2022.04.14.488385; doi: https://doi.org/10.1101/2022.04.14.488385

Assante A, Lkhagvadorj K, Clambey ET, Danhorn T, Merrick DT, Keith RL, New ML, Degregori J, Miller YE, Ghosh M. Reduced Progenitor Function and Altered Immune Landscape Contribute to Field Cancerization of Lung Adenocarcinoma. Am J Respir Crit Care Med. 2023 Oct 15;208(8):903-905. PubMed PMID: 37639330

Vragel G, Gomez BD, Kostelecky RE, Noell KS, Tseng A, Cohen S, Dalwadi M, Medina EM, Nail EA, Goodspeed A, Clambey ET, van Dyk LF. Murine Gammaherpesvirus 68 Efficiently Infects Myeloid Cells Resulting In An Atypical, Restricted Form Of Infection. bioRxiv. 2023 Jun 29. PubMed PMID: 37425871

Kleczko EK, Nguyen DT, Marsh KH, Bauer CD, Li AS, Monaghan MT, Berger MD, Furgeson SB, Gitomer BY, Chonchol MB, Clambey ET, Zimmerman KA, Nemenoff RA, Hopp K. Immune checkpoint activity regulates polycystic kidney disease progression. JCI Insight. 2023 Jun 22;8(12). PubMed PMID: 37345660

Kleczko EK, Hinz TK, Nguyen TT, Gurule NJ, Navarro A, Le AT, Johnson AM, Kwak J, Polhac DI, Clambey ET, Weiser-Evans M, Merrick DT, Yang MC, Patil T, Schenk EL, Heasley LE, Nemenoff RA. Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity. NPJ Precis Oncol. 2023 Feb 4;7(1):15. PubMed PMID: 36739466

Kleczko EK, Le AT, Hinz TK, Nguyen TT, Navarro A, Hu CJ, Selman AM, Clambey ET, Merrick DT, Lu S, Weiser-Evans M, Nemenoff RA, Heasley LE. Novel EGFR-mutant mouse models of lung adenocarcinoma reveal adaptive immunity requirement for durable osimertinib response. Cancer Lett. 2023 Mar 1;556:216062. PubMed PMID: 36657561

Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2023 Jan;4(1):148. PubMed PMID: 36577897

Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2022 Nov;3(11):1300-1317. PubMed PMID: 36434392

Nguyen DT, Kleczko EK, Dwivedi N, Monaghan MT, Gitomer BY, Chonchol MB, Clambey ET, Nemenoff RA, Klawitter J, Hopp K. The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression. JCI Insight. 2023 Jan 10;8(1). PubMed PMID: 36422996

Jones RT, Scholtes M, Goodspeed A, Akbarzadeh M, Mohapatra S, Feldman LE, Vekony H, Jean A, Tilton CB, Orman MV, Romal S, Deiter C, Kan TW, Xander N, Araki SP, Joshi M, Javaid M, Clambey ET, Layer R, Laajala TD, Parker SJ, Mahmoudi T, Zuiverloon TCM, Theodorescu D, Costello JC. NPEPPS Is a Druggable Driver of Platinum Resistance. Cancer Res. 2024 May 15;84(10):1699-1718. PubMed PMID: 38535994

Yee EJ, Gilbert D, Kaplan J, van Dyk L, Kim SS, Berg L, Clambey E, Wani S, McCarter MD, Stewart CL. Immune Landscape of Epstein-Barr Virus-Associated Gastric Cancer: Analysis From a Western Academic Institution. J Surg Res. 2024 Apr;296:742-750. PubMed PMID: 38368775

Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. Publisher Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2024 Jan;5(1):210. PubMed PMID: 38200246

Associate Professor, Anesthesiology

Department

Publications

School of Medicine

CU Anschutz

Fitzsimons Building