Kathryn Hassell, MD

Recognitions

• Top Doctor, 5280 Magazine (2008)
  Awarded since 2003
• Faculty Community Service Award, Bank One Colorado (2003)
  
• Community Service Award, Colorado Coalition for the Medically Underserved (2005)
  
• Clinical Excellence Award, Vascular Disease Foundation (2007)
  
• Top Doctor in Denver, 5280 Magazine (2011)
  Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?"

Research Interests

Dr. Hassell is interested in coagulation disorders including antiphospholipid antibody syndrome and heparin-induced thrombocytopenia, investigation of novel anticoagulant therapies and strategies, hemoglobinopathies/sickle cell disease including mechanisms of vascular injury and chronic organ damage.

Publications

• Hassell, KL. The management of patients with HIT who require anticoagulant therapy. Chest 127;2:1S-8S, 2005.
• Hassell KL. Hematologic Ramifications of Patent Foramen Ovale-role of Hypercoagu-lable State. Cardiol Clin 23:65-71, 2005.
• Lottenberg R, Hassell K. An evidence-based approach to the treatment of adults with sickle cell disease. Hematology 58-65, Jan 2005.
• Hassell KL, Heit JA, Raskob GE, Sacher RA. Mechanisms of Thrombosis and their Im-plications for Therapy. Monograph. University of Colorado Statewide Extended Cam-pus, 2005.
• Hassell K. Pregnancy and Sickle Cell Disease. Hematol Oncol Clin of N Am 19 (2005) 903-916.
• Hassell KL. Hemoglobinopathies in Pregnancy. Current Women’s Health Reviews, 2(1), 2006.
• Hassell, K and Heeney M. Transfusion Therapy for Sickle Cell Disease: Indications and Practical Considerations. Monograph. Health Science Center for Continuing Medical Education, New York, NY, 2005.
• Hassell KL. Deep Venous Thrombosis/Pulmonary Embolism and Heparin-Induced Thrombocytopenia: Recognizing the Overlap Syndrome. ACCP Monograph in press.
• Treadwell MJ, Hassell K, Levine R, Keller S. Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me): Conceptual Model Based on Review of the Literature and Formative Research. Clin J Pain. 2013 Nov 28. [Epub ahead of print] PubMed PMID: 24300219
• Lisk C, Kominsky D, Ehrentraut S, Bonaventura J, Nuss R, Hassell K, Nozik-Grayck E, Irwin DC. Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism. Am J Respir Cell Mol Biol. 2013 Oct;49(4):619-26. PubMed PMID: 23713977
• Delaney KM, Axelrod KC, Buscetta A, Hassell KL, Adams-Graves PE, Seamon C, Kato GJ, Minniti CP. Leg ulcers in sickle cell disease: current patterns and practices. Hemoglobin. 2013;37(4):325-32. PubMed PMID: 23600469
• Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Goldsmith JC, Gordeuk VR, Gladwin MT, Walk-PHASST Investigators and Patients. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica. 2013 Mar;98(3):464-72. PubMed PMID: 22983573
• Hassell K. Hemoglobinopathies in Pregnancy. Current Women's Health Reviews, 2(1),2006
• Best Practices Guidelines for the Managment of Acute and chronic Sickle Cell Pain in Adults. In preparation, 2007
• Irwin DC, Hyen Baek J, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW. Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Free Radic Biol Med. 2015 Feb 2;82:50-62. [Epub ahead of print] PubMed PMID: 25656991
• Savage WJ, Buchanan GR, Yawn BP, Afenyi-Annan AN, Ballas SK, Goldsmith JC, Hassell KL, James AH, John-Sowah J, Jordan L, Lottenberg R, Murad MH, Ortiz E, Tanabe PJ, Ware RE, Lanzkron SM. Evidence gaps in the management of sickle cell disease: A summary of needed research. Am J Hematol. 2015 Jan 12. [Epub ahead of print] PubMed PMID: 25639238
• Yawn BP, Buchanan G, Hassell K. Management of patients with sickle cell disease--reply. JAMA. 2015 Jan 6;313(1):91-2. PubMed PMID: 25562275
• Goodman J, Hassell K, Irwin D, Witkowski EH, Nuss R. The splenic syndrome in individuals with sickle cell trait. High Alt Med Biol. 2014 Dec;15(4):468-71. PubMed PMID: 25361178
• Vinchinsky E, Onyekwere O, Porter J, Swerlow P, Eckman J, Lane P, Files B, Hassell K, et al. A randomized comparison of desferasirox versus deferoxamine for the treatment of trans fusional iron overload in sickle cell disease. Br J Haem, 2006.
• National Quality Forum, technical Review Panel. National Voluntary Consensus Standards for Prevention and Care of Venous Thromboembolism: Policy, Preferred Practices, and Initial Perfomance Measures. A Consensus Report, 2006 ISBM 1-933875-05-4.
• Kluger BM, Hughes RL, Anderson CA, Hassell KL. Non-trumatic carotid dissection and stroke associated with anti-phospholipid antibody syndrome: Report of a case of the literature. 2007, Neurology, India
• Hassell KL. Optimizing Clinical Outcomes for Patients with transfusion Dependent Hematologic Disorders: A CME Certified Highlights Newsletter, published, March 2006
• Quirolo K, Bertolone S, Hassell K, Howard T, King KE, Rhodes DK, Bill J. The evaluation of a new apheresis device for automated red blood cell exchange procedures in patients with sickle cell disease. Transfusion. 2014 Oct 21. [Epub ahead of print] PubMed PMID: 25330984
• Anderson M, Hassell KL, Trujillo TC, Wolfe B. When patients on target-specific oral anticoagulants need surgery. Cleve Clin J Med. 2014 Oct;81(10):629-39. PubMed PMID: 25274657
• Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, Jordan L, Lanzkron SM, Lottenberg R, Savage WJ, Tanabe PJ, Ware RE, Murad MH, Goldsmith JC, Ortiz E, Fulwood R, Horton A, John-Sowah J. Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA. 2014 Sep 10;312(10):1033-48. PubMed PMID: 25203083
• Keller SD, Yang M, Treadwell MJ, Werner EM, Hassell KL. Patient reports of health outcome for adults living with sickle cell disease: development and testing of the ASCQ-Me item banks. Health Qual Life Outcomes. 2014 Aug 22;12:125. PubMed PMID: 25146160
• Hassell KL, Afenyi-Annan A, Ballas SK, Buchanan GR, Eckman JR, Jordan L, Lanzkron S, Lottenberg R, Ware R. Practice guideline for pulmonary hypertension in sickle cell: direct evidence needed before universal adoption. Am J Respir Crit Care Med. 2014 Jul 15;190(2):237-8. PubMed PMID: 25025359
• Hassell KL. Advances in the management of Venous Thromboembolic Disorders Associated with cancer and the Antiphospholipid Syndrome. Mongraph, American Society of Hematology, Dec. 2006
• Dowling NF, Beckman MG, Manco-Johnson M, Hassell KL. The U.S. Thrombosis and Hemostasis Center Pilot Sites Program. J Thromb Thrombolysis, 23(1):1, 2007.
• Hassell K. Venous Thromboembolism and Heparin Induced Thrombocytopenia: A Critical Care Planner. Society of Critical Care Medicine, 2007
• Hassell KL, Gillette S, Accornero N, Holstein D. Identification of Specific Community Needs when Planning Sickle Cell Trait Counseling Programs: The Colorado Experience. Presented at the 35th Anniversary Convention of the National Sickle Cell Disease Pro-gram and the Sickle Cell Disease Association of America, Inc., September 2007, Wash-ington DC.
• Babilonia KM, Golightly LK, Gutman JA, Hassell KL, Kaiser JN, Kiser TH, Klem PM, Trujillo TC. Antithrombotic therapy in patients with thrombocytopenic cancer: outcomes associated with reduced-dose, low-molecular-weight heparin during hospitalization. Clin Appl Thromb Hemost. 2014 Nov;20(8):799-806. PubMed PMID: 25022565
• Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Berman Rosenzweig E, Badesch DB, Lanzkron S, Castro OL, Taylor JG 6th, Goldsmith JC, Kato GJ, Gordeuk VR, Machado RF, walk-PHaSST Investigators and Patients. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. PLoS One. 2014;9(7):e99489. PubMed PMID: 24988120
• Treadwell MJ, Hassell K, Levine R, Keller S. Adult sickle cell quality-of-life measurement information system (ASCQ-Me): conceptual model based on review of the literature and formative research. Clin J Pain. 2014 Oct;30(10):902-14. PubMed PMID: 24300219
• Hassell KL. Sickle Cell Disease Population Estimation: Application of Available Con-temporary Data to traditional Methods. Presented at the 35th Anniversary Convention of the National Sickle Cell Disease Program and the Sickle Cell Disease Association of America, Inc., September 2007, Washington DC.
• Hassell KL. Characteristics of Sucessfully Completed Clinical Studies in Sickle Cell Disease. Presented at the 35th Anniversary Convention of the National Sickle Cell Dis-ease Program and the Sickle Cell Disease Association of America, Inc., September 2007, Washington DC.
• Ambruso DR, LaSalle-Williams M, Le T, Cole L, Hassell KL, Billington C, Nuss R. Extended, Flexible Program Matching Red Cell Antigens for Patients with Sickle Cell Anemia Provides for both Chronic and Intermittent Transfusions. American Society of Hematolog Annual Meetingy, December 2006
• Ambruso DR, LaSalle-Williams M, Le T, Cole L, Hassell KL, Billington C, Nuss R. Autoantibodies in Patients with Sickle Cell Anemia Receiving Extended Antigen Matched Packed Red Cell Exchange. American Society of Hematology Annual Meeting, December 2006.
• Morris CR, Kim HY, Klings ES, Wood J, Porter JB, Trachtenberg F, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Hassell K, Taher A, Neufeld EJ, Thompson AA, Larkin S, Suh JH, Vichinsky EP, Kuypers FA. Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassaemia. Br J Haematol. 2015 Jun;169(6):887-98. PubMed PMID: 25907665
• Ambruso DR, LaSalle-Williams M, Le T, Cole L, Hassell KL, Billington C, Nuss R. Extended Matching of Red Cell Antigens for Patients with Sickle Cell Anemia Decreases the rate of Alloimmunization. American Society of Hematology Annual Meeting, De-cember 2006.
• Hassell KL. Venous Thromboembolism and Heparin-Induced Thrombocytopenia: A Critical Care Planner. Monograph. Society of Critical Care Medicine, 2007.
• Dowling NF, Beckman MG, Manco-Johnson M, Hassell K, Philipp K, Michaels LA, Moll S, Heit JA, Penner JA, Kulkarni J, Pipe R, Bockenstedt S, Andersen P, Crudder J, James S, Zimmerman AH, Ortel TL. The U.S. Thrombosis and Hemostasis Centers pilot sites program. J Thromb Thrombolysis 23(1):1, 2007
• Vincinsky E, Onyekwere O, Porter J, Swerlow P, Eckamn J, Lane P, Files B, Hassell K, et al. A randomized comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease. Br J Haem, 135(3):501, 2007.
• Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW. Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Free Radic Biol Med. 2015 May;82:50-62. PubMed PMID: 25656991
• Savage WJ, Buchanan GR, Yawn BP, Afenyi-Annan AN, Ballas SK, Goldsmith JC, Hassell KL, James AH, John-Sowah J, Jordan L, Lottenberg R, Murad MH, Ortiz E, Tanabe PJ, Ware RE, Lanzkron SM. Evidence gaps in the management of sickle cell disease: A summary of needed research. Am J Hematol. 2015 Apr;90(4):273-5. PubMed PMID: 25639238
• Yawn BP, Buchanan G, Hassell K. Management of patients with sickle cell disease--reply. JAMA. 2015 Jan 6;313(1):91-2. PubMed PMID: 25562275
• Lanzkron S, Hassell KL et al. Provider Barriers to Hydroxyurea use in Adults with Sickle Cell Disease: A survey of the Sickle Cell Disease Adult Provider Network. JNMA 7-260, in press 2008.
• Quirolo K, Bertolone S, Hassell K, Howard T, King KE, Rhodes DK, Bill J. The evaluation of a new apheresis device for automated red blood cell exchange procedures in patients with sickle cell disease. Transfusion. 2015 Apr;55(4):775-81. PubMed PMID: 25330984
• Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, et al. Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA. 2014; 312(10):1033-48. PubMed [journal] PMID: 25203083
• Treadwell MJ, Werner EM, Hassell KL. Patient reports of health outcome for adults living with sickle cell disease: development and testing of the ASCQ-Me item banks. Health Qual Life Outcomes. 2014 Aug 22;12:125. PubMed PMID: 25146160; PubMed Central PMCID: PMC4243820.
• Overholser L, Hassell K, Nuss R, et al. Using patient navigators to help adults with sickle cell disease obtain a primary care home. J Clin Outcomes. 2014;21(7):1
• Goodman J, Hassell K, Irwin D, Witkowska HE, Nuss R. The splenic syndrome: supportive care is generally ideal. High Altitude Medicine & Biology. 2014 Dec;15(4):468-71.
• Pratte K, Baron A, Ogden L, Hassell KL et al. Plasminogen Activator Inhibitor-1 is Associated with Coronary Artery Calcium in Type 1 Diabetes. Journal of Diabetes and Its Complications, in press 2008.
• Keller SD, Yang M, Treadwell MJ, Werner EM, Hassell KL. Patient reports of health outcome for adults living with sickle cell disease: development and testing of the ASCQ-Me item banks. Health Qual Life Outcomes. 2014 Aug 22;12:125. doi: 10.1186/s12955-014-0125-0.
• Babilonia KM, Golightly LK, Gutman JA, Hassell KL, Kaiser JN, Kiser TH, Klem PM, Trujillo TC. Antithrombotic therapy in patients with thrombocytopenic cancer: out-comes associated with reduced-dose, low-molecular-weight heparin during hospitaliza-tion. Clin Appl Thromb Hemost. 2014 Nov;20(8):799-806.
• Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Berman Rosenzweig E, Badesch DB, Lanzkron S, Castro OL, Taylor JG 6th, Goldsmith JC, Kato GJ, Gordeuk VR, Machado RF; walk-PHaSST Investigators and Patients. Risk factors for death in 632 patients with sickle cell disease in the United States and United King-dom. PLoS One 9(7):e99489, 2014
• Kiser T, Hassell KL, Klem P, Burch J. Evaluation of Bivalirudin Dosing Requirements in Patients with Heparin Induces Thrombocytopenia. Pharmacotherapy, in press
• Hassell KL, Afenyi-Annan A, Ballas SK, Buchanan GR, Eckman JR, Jordan L, Lanzkron S, Lottenberg R, Ware R. Practice Guideline for Pulmonary Hypertension in Sickle Cell: Direct Evidence Needed Before Universal Adoption (letter to editor). Am J Resp Crit Care Med 2014 Jul 15;190(2):237-8.
• Kluger BM, Hughes RL, Anderson CA, Hassell KL. Non-trumatic carotid dissection and stroke associated with anti-phospholipid antibody syndrome: Report of a case of the literature. 2007, Neurology, India
• Treadwell MJ, Hassell K, Levine R, Keller S. Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me): Conceptual Model Based on Review of the Literature and Formative Research. Clin J Pain 2014 Oct;30(10):902-14
• Anderson M, Hassell KL, Trujillo TC, Wolfe B. Perioperative Management of the Target-Specific Oral Anticoagulants. Clev Clin J Med. 2014 Oct;81(10):629-39
• Hassell KL. Venous Thromboembolism and Heparin-Induced Thrombocytopenia: A Critical Care Planner. Monograph. Society of Critical Care Medicine, 2007.
• Sickle Cell Disease in Disease of the Kidney & Urinary Tract, Lippencott, Williams and Wilkins (Eds), Chapter 77, 2007
• Sickle Cell Disease, Critical Care Secrets, Parsons, P., and Wiener-Kronish, J. (Eds), Harley & Balfers, Inc., Philadelphia, PA, March, Second Edition 1992, Third Edition, 2002 and Fourth Edition 2007.
• Evensen CT, Treadwell MJ, Keller S, Levine R, Hassell KL, Werner EM, Smith WR. Quality of care in sickle cell disease: Cross-sectional study and development of a measure for adults reporting on ambulatory and emergency department care. Medicine (Baltimore). 2016 Aug;95(35):e4528. PubMed PMID: 27583862
• Hassell KL. Sickle Cell Disease: A Continued Call to Action. Am J Prev Med. 2016 Jul;51(1 Suppl 1):S1-2. PubMed PMID: 27320458
• Hinton CF, Homer CJ, Thompson AA, Williams A, Hassell KL, Feuchtbaum L, Berry SA, Comeau AM, Therrell BL, Brower A, Harris KB, Brown C, Monaco J, Ostrander RJ, Zuckerman AE, Kaye C, Dougherty D, Greene C, Green NS. A framework for assessing outcomes from newborn screening: on the road to measuring its promise. Mol Genet Metab. 2016 Aug;118(4):221-9. PubMed PMID: 27268406
• Luchtman-Jones L, Pressel S, Hilliard L, Brown RC, Smith MG, Thompson AA, Lee MT, Rothman J, Rogers ZR, Owen W, Imran H, Thornburg C, Kwiatkowski JL, Aygun B, Nelson S, Roberts C, Gauger C, Piccone C, Kalfa T, Alvarez O, Hassell K, Davis BR, Ware RE. Effects of hydroxyurea treatment for patients with hemoglobin SC disease. Am J Hematol. 2016 Feb;91(2):238-42. PubMed PMID: 26615793
• Walters MC, De Castro LM, Sullivan KM, Krishnamurti L, Kamani N, Bredeson C, Neuberg D, Hassell KL, Farnia S, Campbell A, Petersdorf E. Indications and Results of HLA-Identical Sibling Hematopoietic Cell Transplantation for Sickle Cell Disease. Biol Blood Marrow Transplant. 2016 Feb;22(2):207-11. PubMed PMID: 26500093
• Eckman JR, Hassell KL, Huggins W, Werner EM, Klings ES, Adams RJ, Panepinto JA, Hamilton CM. Standard measures for sickle cell disease research: the PhenX Toolkit sickle cell disease collections. Blood Adv. 2017 Dec 26;1(27):2703-2711. PubMed PMID: 29296922
• Hulihan M, Hassell KL, Raphael JL, Smith-Whitley K, Thorpe P. CDC Grand Rounds: Improving the Lives of Persons with Sickle Cell Disease. MMWR Morb Mortal Wkly Rep. 2017 Nov 24;66(46):1269-1271. PubMed PMID: 29166365
• Schofield JR, Hassell K. Dosing considerations in the use of the direct oral anticoagulants in the antiphospholipid syndrome. J Clin Pharm Ther. 2018 Feb;43(1):104-106. PubMed PMID: 28656623
• Keller S, Yang M, Treadwell MJ, Hassell KL. Sensitivity of alternative measures of functioning and wellbeing for adults with sickle cell disease: comparison of PROMIS® to ASCQ-Me?. Health Qual Life Outcomes. 2017 Jun 2;15(1):117. PubMed PMID: 28577358
• Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark KR, Buehler PW, Irwin DC. Correction: Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017;12(3):e0173652. PubMed PMID: 28264019
• Nutrition Guide for Clinicians, First Edition, Barnard ND, and Weissinger R, (EDs), Physicians Committee for Responsible Medicine, 2007
• Dowling NF, Beckman MG, Manco-Johnson M, Hassell K et al. The U.S. Thrombosis and Hemostasis Centers pilot sites program. J Thromb Throbolysis 23:1-7, 2007.
• Hassell KL, Gillette S, Accornero N, Holstein D. Identification of Specific Community Needs when Planning Sickle Cell Trait Counseling Programs: The Colorado Experience. Presented at the 35th Anniversary Convention of the National Sickle Cell Disease Pro-gram and the Sickle Cell Disease Association of America, Inc., September 2007, Wash-ington DC.
• Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017;12(2):e0171219. PubMed PMID: 28152051
• Dampier C, Palermo TM, Darbari DS, Hassell K, Smith W, Zempsky W. AAPT Diagnostic Criteria for Chronic Sickle Cell Disease Pain. J Pain. 2017 May;18(5):490-498. PubMed PMID: 28065813
• Hassell KL. Sickle Cell Disease Population Estimation: Application of Available Con-temporary Data to traditional Methods. Presented at the 35th Anniversary Convention of the National Sickle Cell Disease Program and the Sickle Cell Disease Association of America, Inc., September 2007, Washington DC.
• Hassell KL. Characteristics of Sucessfully Completed Clinical Studies in Sickle Cell Disease. Presented at the 35th Anniversary Convention of the National Sickle Cell Dis-ease Program and the Sickle Cell Disease Association of America, Inc., September 2007, Washington DC.
• Burch JC, Klem PM, Hassell KL, Kiser TH. Evaluation of bivalirudin dosing require-ments in patients with heparin indiced thrombocytopenia (HIT). ACCP Annual Meeting, Denver, CO Oct. 2007.
• Naik RP, Smith-Whitley K, Hassell KL, Umeh NI, de Montalembert M, Sahota P, Haywood C Jr, Jenkins J, Lloyd-Puryear MA, Joiner CH, Bonham VL, Kato GJ. Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review. Ann Intern Med. 2018 Nov 6;169(9):619-627. PubMed PMID: 30383109
• Yalamanoglu A, Deuel JW, Hunt RC, Baek JH, Hassell K, Redinius K, Irwin DC, Schär DJ, Buehler PW. Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 26. [Epub ahead of print] PubMed PMID: 30047285
• Ferguson SK, Redinius K, Yalamanoglu A, Harral JW, Hyen Baek J, Pak D, Loomis Z, Hassell D, Eigenberger P, Nozik-Grayck E, Nuss R, Hassell K, Stenmark KR, Buehler PW, Irwin DC. Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia. J Physiol. 2018 Jun 21. [Epub ahead of print] PubMed PMID: 29931797
• Krishnamurti L, Neuberg DS, Sullivan KM, Kamani NR, Abraham A, Campigotto F, Zhang W, Dahdoul T, De Castro L, Parikh S, Bakshi N, Haight A, Hassell KL, Loving R, Rosenthal J, Smith SL, Smith W, Spearman M, Stevenson K, Wu CJ, Wiedl C, Waller EK, Walters MC. Bone Marrow Transplantation for Adolescents and Young Adults with Sickle Cell Disease: Results of a Prospective Multicenter Pilot Study. Am J Hematol. 2019 Jan 13. [Epub ahead of print] PubMed PMID: 30637784
• Schofield JR, Hassell K. Dosing considerations in the use of the direct oral anticoagulants in the antiphospholipid syndrome. J Clin Pharm Ther. 2018 Feb;43(1):104-106. PubMed PMID: 28656623
• Ambruso DR, LaSalle-Williams M, Le T, Cole L, Hassell KL, Billington C, Nuss R. Extended, Flexible Program Matching Red Cell Antigens for Patients with Sickle Cell Anemia Provides for both Chronic and Intermittent Transfusions. American Society of Hematolog Annual Meetingy, December 2007
• Farrell AT, Panepinto J, Desai AA, Kassim AA, Lebensburger J, Walters MC, Bauer DE, Blaylark RM, DiMichele DM, Gladwin MT, Green NS, Hassell K, Kato GJ, Klings ES, Kohn DB, Krishnamurti L, Little J, Makani J, Malik P, McGann PT, Minniti C, Morris CR, Odame I, Oneal PA, Setse R, Sharma P, Shenoy S. End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings. Blood Adv. 2019 Dec 10;3(23):4002-4020. PubMed PMID: 31809537
• Ambruso DR, LaSalle-Williams M, Le T, Cole L, Hassell KL, Billington C, Nuss R. Autoantibodies in Patients with Sickle Cell Anemia Receiving Extended Antigen Matched Packed Red Cell Exchange. American Society of Hematology Annual Meeting, December 2007.
• Ambruso DR, LaSalle-Williams M, Le T, Cole L, Hassell KL, Billington C, Nuss R. Extended Matching of Red Cell Antigens for Patients with Sickle Cell Anemia Decreases the rate of Alloimmunization. American Society of Hematology Annual Meeting, De-cember 2007
• Redinus K, Baek JH, Yalamanoglu A, Shin HKH, Moldova R, Harral JW, Swindle D, Pak D, Ferguson SK, Nuss R, Hassell K, Nozik-Grayck E, Palmer AF, Fini MA, Karoor V, Stenmark KR, Buehler PW, Irwin DC. An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI Insight. 2019 Aug 8;4(15). PubMed PMID: 31391342
• Krishnamurti L, Neuberg DS, Sullivan KM, Kamani NR, Abraham A, Campigotto F, Zhang W, Dahdoul T, De Castro L, Parikh S, Bakshi N, Haight A, Hassell KL, Loving R, Rosenthal J, Smith SL, Smith W, Spearman M, Stevenson K, Wu CJ, Wiedl C, Waller EK, Walters MC. Bone marrow transplantation for adolescents and young adults with sickle cell disease: Results of a prospective multicenter pilot study. Am J Hematol. 2019 Apr;94(4):446-454. PubMed PMID: 30637784
• Ferguson SK, Redinius K, Yalamanoglu A, Harral JW, Hyen Baek J, Pak D, Loomis Z, Hassell D, Eigenberger P, Nozik-Grayck E, Nuss R, Hassell K, Stenmark KR, Buehler PW, Irwin DC. Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia. J Physiol. 2019 Feb;597(4):1073-1085. PubMed PMID: 29931797
• Sickle cell disease summit: from clinical and research disparity to action. Hassell K, Pace B, Wang W, Kulkarni R, Luban N, Johnson CS, Eckman J, Lane P, Woods WG; American Society of Pediatric Hematology Oncology. Am J Hematol. 2009 Jan;84(1):39-45.
• Heparin-induced thrombocytopenia: diagnosis and management. Hassell K. Thromb Res. 2008;123 Suppl 1:S16-21. Epub 2008 Oct 1. Review.
• Plasminogen activator inhibitor-1 is associated with coronary artery calcium in Type 1 diabetes. Pratte KA, Barón AE, Ogden LG, Hassell KL, Rewers M, Hokanson JE. J Diabetes Complications. 2008 Sep 1. [Epub ahead of print]
• Cabana MD, Marsh A, Treadwell MJ, Stemmler P, Rowland M, Bender MA, Bhasin N, Chung JH, Hassell K, Abdul Rashid NFN, Wong TE, Bardach NS. Improving Preventive Care for Children With Sickle Cell Anemia: A Quality Improvement Initiative. Pediatr Qual Saf. 2021 Jan-Feb;6(1):e379. PubMed PMID: 33409431
• Schofield JR, Hughes HN, Birlea M, Hassell KL. A trial of antithrombotic therapy in patients with refractory migraine and antiphospholipid antibodies: A retrospective study of 75 patients. Lupus. 2021 Jan 5;:961203320983913. [Epub ahead of print] PubMed PMID: 33402037
• Bender MA, Yusuf C, Davis T, Dorley MC, Del Pilar Aguinaga M, Ingram A, Chan MS, Ubaike JC, Hassell K, Ojodu J, Hulihan M. Newborn Screening Practices and Alpha-Thalassemia Detection - United States, 2016. MMWR Morb Mortal Wkly Rep. 2020 Sep 11;69(36):1269-1272. PubMed PMID: 32915167
• Safety, efficacy, and dosing requirements of bivalirudin in patients with heparin-induced thrombocytopenia. Kiser TH, Burch JC, Klem PM, Hassell KL. Pharmacotherapy. 2008 Sep;28(9):1115-24.
• Provider barriers to hydroxyurea use in adults with sickle cell disease: a survey of the Sickle Cell Disease Adult Provider Network. Lanzkron S, Haywood C Jr, Hassell KL, Rand C. J Natl Med Assoc. 2008 Aug;100(8):968-73.
• Population estimates of sickle cell disease in the U.S. Hassell KL. Hassell KL. Population estimates of sickle cell disease in the U.S. Am J Prev Med. 2010 Apr;38(4 Suppl):S512-21
• Karoor V, Swindle D, Pak DI, Strassheim D, Fini MA, Dempsey E, Stenmark KR, Hassell K, Nuss R, Buehler PW, Irwin DC. Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia. Pulm Circ. 2021 Oct-Dec;11(4):20458940211056806. PubMed PMID: 34777787
• Tyree H. Kiser, Allison M. Mann, Toby C. Trujillo, and Kathryn L. Hassell. Evaluation of empiric versus nomogram-based direct thrombin inhibitor management in patients with suspected heparin-induced thrombocytopenia. American J Hematology 2011 Mar;86(3):267-72
• Lasalle-Williams M, Nuss R, Le T, Cole L, Hassell K, Murphy JR, Ambruso DR. Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14-year experience from a single center. Transfusion. 2011 Feb 18. doi: 10.1111/j.1537-2995
• Quinn CT, Johnson VL, Kim HY, Trachtenberg F, Vogiatzi MG, Kwiatkowski JL, Neufeld EJ, Fung E, Oliveri N, Kirby M, Giardina PJ; Thalassemia Clinical Research Network. Renal dysfunction in patients with thalassaemia Br J Haematol. 2011 Apr;153(1):111-7. doi: 10.1111/j.1365-2141.2010.08477.x. Epub 2011 Feb 21.
• Thompson AA, Cunningham MJ, Singer ST, Neufeld EJ, Vichinsky E, Yamashita R, Giardina P, Kim HY, Trachtenberg F, Kwiatkowski JL; Thalassemia Clinical Research Network Investigators. Red cell alloimmunization in a diverse population of transfused patients with thalassaemia. Br J Haematol. 2011 Apr;153(1):121-8. doi: 10.1111/j.1365-2141.2011.08576.x. Epub 2011 Feb 17
• Tanabe P, Porter J, Creary M, Kirkwood E, Miller S, Ahmed-Williams E, Hassell K. A qualitative analysis of best self-management practices: sickle cell disease J Natl Med Assoc. 2010 Nov;102(11):1033-41.
• Buehler PW, Swindle D, Pak DI, Fini MA, Hassell K, Nuss R, Wilkerson RB, D'Alessandro A, Irwin DC. Murine models of sickle cell disease and beta-thalassemia demonstrate pulmonary hypertension with distinctive features. Pulm Circ. 2021 Oct-Dec;11(4):20458940211055996. PubMed PMID: 34777785
• Sobota A, Yamashita R, Xu Y, Trachtenberg F, Kohlbry P, Kleinert DA, Giardina PJ, Kwiatkowski JL, Foote D, Thayalasuthan V, Porter JB, Thompson AA, Schilling L, Quinn CT, Neufeld EJ; Thalassemia Clinical Research Network. Quality of life in thalassemia: a comparison of SF-36 results from the thalassemia longitudinal cohort to reported literature and the US norms Am J Hematol. 2011 Jan;86(1):92-5
• Liles DK, Shah NR, Scullin B, Gordeuk VR, Smith WR, Kanter J, Achebe MM, Boccia R, Crary SE, Kraft WK, Archer N, Cataldo V, Hardesty BM, Idowu M, Desai PC, Ikeda A, Puthenveetil G, Hassell KL, Sarnaik S, Kutlar A. Long-term biological effects in sickle cell disease: insights from a post-crizanlizumab study. Br J Haematol. 2021 Nov;195(4):e150-e153. PubMed PMID: 34611900
• Buehler PW, Swindle D, Pak DI, Ferguson SK, Majka SM, Karoor V, Moldovan R, Sintas C, Black J, Gentinetta T, Buzzi RM, Vallelian F, Wassmer A, Edler M, Bain J, Schu D, Hassell K, Nuss R, Schaer DJ, Irwin DC. Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease. Free Radic Biol Med. 2021 Nov 1;175:95-107. PubMed PMID: 34478834
• Farrar JE, Trujillo TC, Mueller SW, Beltran L, Nguyen C, Hassell K, Kiser TH. Evaluation of a patient specific, targeted-intensity pharmacologic thromboprophylaxis protocol in hospitalized patients with COVID-19. J Thromb Thrombolysis. 2021 Aug 19. [Epub ahead of print] PubMed PMID: 34410561
• Kiser TH, MacLaren R, Fish DN, Hassell KL, Teitelbaum I. Bivalirudin versus unfractionated heparin for prevention of hemofilter occlusion during continuous renal replacement therapy Pharmacotherapy. 2010 Nov;30(11):1117-26
• Machado RF, Barst RJ, Yovetich NA, Hassell KL, Kato GJ, Gordeuk VR,Gibbs JSR,Little JA, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR,Berman Rosenzweig E, Badesch DB, Lanzkron S, Onyekwere O, Castro OL, Sachdev V, Waclawiw MA, Woolson R, Goldsmith J, and Gladwin MT, on behalf of the Walk-PHASST Investigators and Patients. Hospitalization for Pain in Patients with Sickle Cell Disease Treated with Sildenafil for Elevated TRV and Low Exercise Capacity. Blood, accepted for publication, in press.
• Vichinsky E, Bernaudin F, Forni GL,Gardner R,Hassell KL, Heeney M, Inusa B, Kutlar A, Lane P, Mathias L, Porter J, Tebbi C, Wilson F, Griffel L, Deng W, Giannone V, and Coates T. Long-term safety and efficacy of deferasirox (Exjade®) for up to 5 years in transfusional iron overloaded patients with sickle cell disease. Accepted British J Haematology, in press, 2011
• Pulmonary hypertension, tricuspid regurgitant velocity screening, and the nitric oxide pathway.Hematology Am Soc Hematol Educ Program, 2011;2011:419-26.
• Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Taylor JG 6th, Hannoush H, Goldsmith JC, Gladwin MT, Gordeuk VR; Walk-PHASST Investigators. Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom. Circulation. 2011 Sep 27;124(13):1452-60. Epub 2011 Sep 6.
• Morris CR, Kim HY, Trachtenberg F, Wood J, Quinn CT, Sweeters N, Kwiatkowski JL, Thompson AA, Giardina PJ, Boudreaux J, Olivieri NF, Porter JB, Neufeld EJ, Vichinsky EP; Thalassemia Clinical Research Network. Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report. Blood, 2011 Oct 6;118(14):3794-802. Acknowledgement as part of Network during NIH duty - contributed but scientific study and manuscriptcouldn't be listed as author)
• Olivieri NF, Saunthararajah Y, Thayalasuthan V, Kwiatkowski J, Ware RE, Kuypers FA, Kim HY, Trachtenberg FL, Vichinsky EP; Thalassemia Clinical Research Network. A pilot study of subcutaneous decitabine in ß-thalassemia intermedia. Blood. 2011 Sep 8;118(10):2708-11. Epub 2011 Jun 23. (Acknowledgement as part of Network during NIH duty - contributed to scientific study and manuscript but couldn't be listed as author)
• Ruchika Goel, MD, MPH1, Kathryn L. Hassell, MD, Roberto F Machado, MD, Robyn J. Barst, MD, Nancy Yovetich, Gregory J. Kato, MD, Victor R. Gordeuk, MD, Jane A Little8, J Simon R Gibbs, MD, Dean E. Schraufnagel, MD, Reda E. Girgis, MD, Erika Berman Rosenzweig, MD, Claudia R. Morris, MD, David B. Badesch, MD, Sophie Lanzkron, MD, MHS, Onyinye Onyekwere, MD, MS, Mehdi Nouraie, MD, PhD, Oswaldo L Castro, MD, Vandana Sachdev, MD*, Myron Waclawiw, Robert Woolson, Jonathan C. Goldsmith, MD, Mark T Gladwin, MD and Lakshmanan Krishnamurti, MD. Non-Cardiopulmonary Factors Affecting the Six-Minute Walk Distance in Patients with Sickle Cell Disease: Results From the Walk-PHaSST Study. ASH Meeting, 2011
• Rushing JS, Appiah L, Polotsky AJ, Murray S, Foust E, Hassell K, Roeca C. Ovarian stimulation for fertility preservation in an oncology patient with etonogestrel implant in place. J Assist Reprod Genet. 2021 Feb;38(2):513-516. PubMed PMID: 33409752
• Cabana MD, Marsh A, Treadwell MJ, Stemmler P, Rowland M, Bender MA, Bhasin N, Chung JH, Hassell K, Abdul Rashid NFN, Wong TE, Bardach NS. Improving Preventive Care for Children With Sickle Cell Anemia: A Quality Improvement Initiative. Pediatr Qual Saf. 2021 Jan-Feb;6(1):e379. PubMed PMID: 33409431
• Schofield JR, Hughes HN, Birlea M, Hassell KL. A trial of antithrombotic therapy in patients with refractory migraine and antiphospholipid antibodies: A retrospective study of 75 patients. Lupus. 2021 Apr;30(4):568-577. PubMed PMID: 33402037
• Yingze Zhang, PhD, Qilu Zeng, MS, Inna Belfer, MD, Ruchika Goel, MD, MPH, Martha Porter, Yanxia Chu, MD, Robyn J. Barst, MD, Kathryn L. Hassell, MD, Roberto F Machado, MD, Jonathan C. Goldsmith, MD, Mark T Gladwin, MD1, and Lakshmanan Krishnamurti, MD. Association of Genetic Variation in the Catechol-O-Methyl Transferase Gene with Pain and Six Minute Walk Distance in Sickle Cell Anemia Patients From the Walk-PHaSST Study. ASH Meeting 2011
• Ellen Werner, PhD and Kathryn Hassell, MD. Harmonization of Diagnostic Criteria for Hemoglobinopathies among State NBS Programs. Annual American Public Health Association Meeting, 2011
• Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Goldsmith JC, Gordeuk VR, Gladwin MT; Walk-PHASST Investigators and Patients. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica. 2013 Mar;98(3):464-72. doi: 10.3324/haematol.2012.068965. Epub 2012 Sep 14
• Dampier CD, Telen MJ, Wun T, Brown C, Desai PC, El Rassi F, Fuh B, Kanter J, Pastore YD, Rothman J, Taylor JG, Readett D, Sivamurthy KM, Tammara B, Tseng LJ, Lozier JN, Thackray HM, Magnani JL, Hassell K. A Randomized Clinical Trial of the Efficacy and Safety of Rivipansel for Sickle Cell Vaso-occlusive Crisis (VOC). Blood. 2022 Aug 18. [Epub ahead of print] PubMed PMID: 35981565
• Farrar JE, Trujillo TC, Mueller SW, Beltran L, Nguyen C, Hassell K, Kiser TH. Evaluation of a patient specific, targeted-intensity pharmacologic thromboprophylaxis protocol in hospitalized patients with COVID-19. J Thromb Thrombolysis. 2022 Feb;53(2):446-453. PubMed PMID: 34410561
• Lisk C, Cendali F, Setua S, Thangaraju K, Pak DI, Swindle D, Dzieciatkowska M, Gamboni F, Hassell K, Nuss R, George G, Davizon-Castillo P, Buehler PW, D'Alessandro A, Irwin DC. Metabolic and Proteomic Divergence Is Present in Circulating Monocytes and Tissue-Resident Macrophages from Berkeley Sickle Cell Anemia and ß-Thalassemia Mice. J Proteome Res. 2023 Sep 1;22(9):2925-2935. PubMed PMID: 37606205
• Lisk C, Cendali F, Pak DI, Swindle D, Hassell K, Nuss R, George G, Davizon-Castillo P, Buehler PW, D'Alessandro A, Irwin DC. Moderate hypoxia induces metabolic divergence in circulating monocytes and tissue resident macrophages from Berkeley sickle cell anemia mice. Front Med (Lausanne). 2023;10:1149005. PubMed PMID: 37502360
• Thangaraju K, Setua S, Lisk C, Swindle D, Stephenson D, Dzieciatkowska M, Lamb DR, Moitra P, Pak D, Hassell K, George G, Nuss R, Davizon-Castillo P, Stenmark KR, D'Alessandro A, Irwin DC, Buehler PW. Extracellular Vesicle Size Reveals Cargo Specific to Coagulation and Inflammation in Pediatric and Adult Sickle Cell Disease. Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231186144. PubMed PMID: 37469147
• Singh A, Sontag MK, Zhou M, Dasgupta M, Crume T, McLemore M, Galadanci N, Randall E, Steiner N, Brandow AM, Koch K, Field JJ, Hassell K, Snyder AB, Kanter J. Evaluating the Discriminatory Ability of the Sickle Cell Data Collection Program's Administrative Claims Case Definition in Identifying Adults With Sickle Cell Disease: Validation Study. JMIR Public Health Surveill. 2023 Jun 28;9:e42816. PubMed PMID: 37379070
• Schofield JR, Hassell KL. What you need to know about migraine in Hughes syndrome patients. Lupus. 2023 Mar;32(3):319-324. PubMed PMID: 36708185
• Dampier CD, Telen MJ, Wun T, Brown RC, Desai P, El Rassi F, Fuh B, Kanter J, Pastore Y, Rothman J, Taylor JG, Readett D, Sivamurthy KM, Tammara B, Tseng LJ, Lozier JN, Thackray H, Magnani JL, Hassell KL. A randomized clinical trial of the efficacy and safety of rivipansel for sickle cell vaso-occlusive crisis. Blood. 2023 Jan 12;141(2):168-179. PubMed PMID: 35981565

Professional Memberships

• American Heart Association (AHA), Council on Thrombosis Member
• American Society of Hematology, Member
• International Society of Thrombosis & Haemostasis, Member
• University of Colorado Cancer Center, Member
• American Society of Clinical Pathologists, Member
• Mountain States Regional Genetics Collaborative, Member
• American Pain Society, Member

Practice Locations

UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Blood Disorders and Cell Therapies Center - Anschutz Medical Campus
1665 Aurora Court
3rd floor, Anschutz Cancer Pavilion
Aurora, CO 80045
720-848-6400

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• University of Colorado Cancer Center
• Colorado Sickle Cell Treatment and Research Center

Specialty Information

Specialties

• Internal Medicine, Board Certification (1989)
• Hematology, Board Certification (2001)
• Medical Oncology, Board Certification (2001)

Conditions & Treatments

• Blood / Lymphatic System
• Blood / Lymphatic System - Clotting Disorders