Richard Johnson, MD

Professor Emeritus, Medicine-Renal Med Diseases/Hypertension

FacultyPhoto
Medical School
  • MD, University of Minnesota Medical School (1979)
Undergraduate School
  • BS, University of Wisconsin–Madison (WI) (1975)
Internship
  • University of Washington Program (1980)
Residency
  • University of Washington Program, Internal Medicine (1982)
Fellowships
  • University of Washington Program, Infectious Disease (1986)
  • University of Washington Program, Nephrology (1986)
Languages
English
Department
Medicine-Renal Med Diseases/Hypertension

Professional Titles

  • Professor Emeritus

Publications

  • Sánchez-Lozada LG, Tapia E, Vega-Campos IP, Cristóbal M, Soto V, T Ávila-Casado C, Franco M, Zhao L, Johnson RJ. Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricemia. Nephrol Dial Transpl 2008 Apr;23(4):1179-85
  • Reungjui S, Roncal CA, Sato W, Glushakova OY, Ouyang X, Tungsanga K, Nakagawa T, Johnson RJ, Mu W. Hypokalemic Nephropathy is associated with Impaired Angiogenesis J Am Soc Nephrol 2008 Jan;19(1):125-34
  • Hohenstein B, Braun A, Amann K, Johnson RJ, Hugo CPM. A Murine Model of Site specific Renal Microvascular Endothelial Injury and thrombotic microangiopathy. Nephrol Dial Transpl 2008 Apr;23(4):1144-56
  • Franco M, Sanchez-Lozada LG, , Bautista R, Johnson R, Rodriguez-Iturbe B. Pathophysiology of salt sensitive hypertension: a new scope of an old problem.Blood Purification 2008;26(1):45-8.
  • Johnson RJ, Gaucher E, Sautin YY, Henderson GN, Angerhofer AJ, Benner SA. The Planetary Biology of Ascorbate and Uric acid and their Relationship with the Epidemic of Obesity and Cardiovascular Disease. Med Hypotheses 2008;71(1):22-31
  • Sanchez-Lozada LG, Tapia E, Bautista-Garcia P, Soto V, Avila-Casado C, Vega-Campos I, Nakagawa T, Zhao L, Franco M, Johnson RJ. Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2008 Apr;294(4):F710-8
  • Ouyang X, Cirillo P, Sautin YY, McCall S, Bruchette JL, Diehl AM, Johnson RJ, Abdelmalak M. Fructose Consumption as a Risk Factor for Nonalcoholic Fatty Liver Disease. J Hepatol 2008 Jun;48(6):993-9
  • Sanchez-Lozada LG, Tapia E, Soto V, Avila-Casado C, Franco M, Wessale J, Zhao L, Johnson RJ. Effect of febuxostat on the progression of renal disease in 5/6th nephrectomy rats with and without hyperuricemia. Nephron Physiology 2008;108(4):p69-78
  • Bjornstad P, Snell-Bergeon JK, McFann K, Wadwa RP, Rewers M, Rivard CJ, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Serum uric acid and insulin sensitivity in adolescents and adults with and without type 1 diabetes. J Diabetes Complications. 2013 Dec 27. [Epub ahead of print] PubMed PMID: 24461546
  • Nakagawa T, Sato W, Kosugi T, Johnson RJ. Uncoupling of VEGF with endothelial NO as a potential mechanism for abnormal angiogenesis in the diabetic nephropathy. J Diabetes Res. 2013;2013:184539. PubMed PMID: 24386643
  • Roncal Jimenez CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, González MA, Aragón A, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2013 Dec 11. [Epub ahead of print] PubMed PMID: 24336030
  • Cara-Fuentes G, Wei C, Segarra A, Ishimoto T, Rivard C, Johnson RJ, Reiser J, Garin EH. CD80 and suPAR in patients with minimal change disease and focal segmental glomerulosclerosis: diagnostic and pathogenic significance. Pediatr Nephrol. 2013 Nov 22. [Epub ahead of print] PubMed PMID: 24263531
  • Stenvinkel P, Johnson RJ. Kidney biomimicry--a rediscovered scientific field that could provide hope to patients with kidney disease. Arch Med Res. 2013 Nov;44(8):584-90. PubMed PMID: 24220764
  • Johnson RJ, Nakagawa T, Sánchez-Lozada LG, Lanaspa MA, Tamura Y, Tanabe K, Ishimoto T, Thomas J, Inaba S, Kitagawa W, Rivard CJ. Umami: the taste that drives purine intake. J Rheumatol. 2013 Nov;40(11):1794-6. PubMed PMID: 24187156
  • Cara-Fuentes G, Araya C, Wei C, Rivard C, Ishimoto T, Reiser J, Johnson RJ, Garin EH. CD80, suPAR and nephrotic syndrome in a case of NPHS2 mutation. Nefrologia. 2013;33(5):727-31. PubMed PMID: 24089165
  • Stenvinkel P, Fröbert O, Anderstam B, Palm F, Eriksson M, Bragfors-Helin AC, Qureshi AR, Larsson T, Friebe A, Zedrosser A, Josefsson J, Svensson M, Sahdo B, Bankir L, Johnson RJ. Metabolic changes in summer active and anuric hibernating free-ranging brown bears (Ursus arctos). PLoS One. 2013;8(9):e72934. PubMed PMID: 24039826
  • Rodriguez Iturbe B, Johnson RJ. Reply to Dr Jenkins. Am J Kid Dis (letter) 2008; 51:1075.
  • Bjornstad P, Snell-Bergeon JK, Rewers M, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Early diabetic nephropathy: a complication of reduced insulin sensitivity in type 1 diabetes. Diabetes Care. 2013 Nov;36(11):3678-83. PubMed PMID: 24026551
  • Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434. PubMed PMID: 24022321
  • Reungjui S, Pratipanawatr T, Johnson RJ, and Nakagawa T. Do Thiazides Worsen Metabolic Syndrome and Renal Disease: The pivotal roles for Hyperuricemia and Hypokalemia. Current Opinion in Nephrology and Hypertension 2008; 17:470-476.
  • Johnson RJ, Sánchez-Lozada LG. Chronic kidney disease: Mesoamerican nephropathy--new clues to the cause. Nat Rev Nephrol. 2013 Oct;9(10):560-1. PubMed PMID: 23999393
  • Hernández-Ríos R, Hernández-Estrada S, Cruz-Robles D, Hernández-Lobato S, Villalobos-Martín M, Johnson RJ, Rodríguez-Castellanos F, Salazar J, García-Arroyo F, Sánchez-Lozada LG, Madero M. Low fructose and low salt diets increase mitochondrial DNA in white blood cells of overweight subjects. Exp Clin Endocrinol Diabetes. 2013 Oct;121(9):535-8. PubMed PMID: 23934680
  • Fini MA, Johnson RJ, Stenmark KR, Wright RM. Hypertension, nitrate-nitrite, and xanthine oxidoreductase catalyzed nitric oxide generation: pros and cons. Hypertension. 2013 Sep;62(3):e9. PubMed PMID: 23897071
  • Maahs DM, Jalal D, Chonchol M, Johnson RJ, Rewers M, Snell-Bergeon JK. Impaired renal function further increases odds of 6-year coronary artery calcification progression in adults with type 1 diabetes: the CACTI study. Diabetes Care. 2013 Sep;36(9):2607-14. PubMed PMID: 23835686
  • Lotan Y, Daudon M, Bruyère F, Talaska G, Strippoli G, Johnson RJ, Tack I. Impact of fluid intake in the prevention of urinary system diseases: a brief review. Curr Opin Nephrol Hypertens. 2013 May;22 Suppl 1:S1-10. PubMed PMID: 23673384
  • Dharnidharka VR, Johnson RJ. Uric acid-- a bad acid for the kidney? Pediatric Transplantation 2008; 12(8): p. 821-2.
  • Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, Maclean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov;58(5):1632-43. PubMed PMID: 23813872
  • Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides and Nucleic Acids 2008 Jun;27(6):608-19
  • Luks AM, Johnson RJ, Swenson ER. Chronic kidney disease at high altitude. J Am Soc Nephrol 2008;19:2262-71.
  • Eckardt KU, Coresh J, Devuyst O, Johnson RJ, Köttgen A, Levey AS, Levin A. Evolving importance of kidney disease: from subspecialty to global health burden. Lancet. 2013 Jul 13;382(9887):158-69. PubMed PMID: 23727165
  • Ishimoto T, Cara-Fuentes G, Wang H, Shimada M, Wasserfall CH, Winter WE, Rivard CJ, Araya CE, Saleem MA, Mathieson PW, Johnson RJ, Garin EH. Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes. Pediatr Nephrol. 2013 Sep;28(9):1803-12. PubMed PMID: 23689904
  • Kanbay M, Turak O, Johnson RJ. REPLY TO: Serum uric acid still carries controversies about its role in endothelial dysfunction. J Clin Hypertens (Greenwich). 2013 Apr;15(4):297. PubMed PMID: 23551732
  • Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E. Uric acid and chronic kidney disease: which is chasing which?. Nephrol Dial Transplant. 2013 Sep;28(9):2221-8. PubMed PMID: 23543594
  • Johnson RJ, Sánchez-Lozada LG, Mazzali M, Feig DI, Kanbay M, Sautin YY. What are the key arguments against uric acid as a true risk factor for hypertension?. Hypertension. 2013 May;61(5):948-51. PubMed PMID: 23460277
  • Johnson RJ, Rivard C, Lanaspa MA, Otabachian-Smith S, Ishimoto T, Cicerchi C, Cheeke PR, Macintosh B, Hess T. Fructokinase, Fructans, Intestinal Permeability, and Metabolic Syndrome: An Equine Connection?. J Equine Vet Sci. 2013 Feb;33(2):120-126. PubMed PMID: 23439477
  • Inaba S, Sautin Y, Garcia GE, Johnson RJ. What can asymptomatic hyperuricaemia and systemic inflammation in the absence of gout tell us?. Rheumatology (Oxford). 2013 Jun;52(6):963-5. PubMed PMID: 23413026
  • Nakagawa T, Cirillo P, Sato W, Sautin M, Roncal C, Sanchez-Lozada, Johnson RJ.. The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med 2008; 3:313-8.
  • Shroff RC, Price KL, Kolatsi-Joannou M, Todd AF, Wells D, Deanfield J, Johnson RJ, Rees L, Woolf AS, Long DA. Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis. PLoS One. 2013;8(2):e56273. PubMed PMID: 23409162
  • Segal MS, Sanchez-Lozada LG, Johnson RJ. Reply to RJ Hine and JS White. Am J Clin Nutr (letter) 2008; 87:1063-1065
  • Glushakova O, Kosugi T, Roncal C, Mu W, Heinig M, Cirillo P, Sanchez-Lozada LG, Johnson RJ, Nakagawa T. Fructose Induces the Inflammatory Molecule ICAM-1 in Endothelial Cells J Am Soc Nephrol 2008; 19:1712-1720
  • Rivard C, Thomas J, Lanaspa MA, Johnson RJ. Sack and sugar, and the aetiology of gout in England between 1650 and 1900. Rheumatology (Oxford). 2013 Mar;52(3):421-6. PubMed PMID: 23175570
  • Rodriguez-Iturbe B, Franco M, Johnson RJ. Impaired pressure natriuresis is associated with interstitial inflammation in salt-sensitive hypertension. Curr Opin Nephrol Hypertens. 2013 Jan;22(1):37-44. PubMed PMID: 23165109
  • Sirota JC, McFann K, Targher G, Johnson RJ, Chonchol M, Jalal DI. Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism. 2013 Mar;62(3):392-9. PubMed PMID: 23036645
  • Stenvinkel P, Jani AH, Johnson RJ. Hibernating bears (Ursidae): metabolic magicians of definite interest for the nephrologist. Kidney Int. 2013 Feb;83(2):207-12. PubMed PMID: 23254895
  • Turak O, Ozcan F, Tok D, Isleyen A, Sökmen E, Tasoglu I, Aydogdu S, Sen N, McFann K, Johnson RJ, Kanbay M. Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. J Clin Hypertens (Greenwich). 2013 Jan;15(1):7-13. PubMed PMID: 23282120
  • Le M, Shafiu M, Mu W, Johnson RJ. SLC2A9—a fructose transporter identified as a novel uric acid transporter. Nephrol Dial Transpl 2008; 23:2746-9
  • Pons H, Ferrebuz A, Quiroz Y, Romero-Vasquez F, Parra G, Johnson RJ, Rodriguez-Iturbe B. Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension. Am J Physiol Renal Physiol. 2013 Feb 1;304(3):F289-99. PubMed PMID: 23097471
  • Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med 2008; 359:1811-21.
  • Sanchez-Lozada LG, Soto V, Tapia E, Avila-Casado C, Sautin YY, Nakagawa T, Franco M, Rodriguez-Iturbe B, Johnson RJ. Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. Am J Physiol Renal Physiol 2008; 295:F1134-41.
  • Feig DI, Soletsky B, Johnson RJ. Effect of Allopurinol on the Blood Pressure of Adolescents with Newly Diagnosed Essential Hypertension. JAMA 2008;300(8):922-30
  • Ejaz AA, Dass B, Lingegowda V, Shimada M, Beaver TM, Ejaz NI, Abouhamze AS, Johnson RJ. Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. Int Urol Nephrol. 2013 Apr;45(2):449-58. PubMed PMID: 22648289
  • Le MT, Lobmeyer MT, Campbell M, Cheng J, Wang Z, Turner ST, Chapman AB, Boerwinkle E, Gums JG, Gong Y, Johnson RJ, Johnson JA. Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individuals. PLoS One. 2013;8(1):e52062. PubMed PMID: 23341889
  • Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ, Scarpace PJ. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol 2008;295:R1370-5.
  • Rodriguez-Iturbe B, Vaziri ND, Johnson RJ. Inflammation, angiotensin II, and hypertension. Hypertension 2008;52:e135; author reply e6.
  • Vasiliou V, Sandoval M, Backos DS, Jackson BC, Chen Y, Reigan P, Lanaspa MA, Johnson RJ, Koppaka V, Thompson DC. ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1. Chem Biol Interact. 2013 Feb 25;202(1-3):22-31. PubMed PMID: 23348497
  • Tapia E, Cristóbal M, García-Arroyo FE, Soto V, Monroy-Sánchez F, Pacheco U, Lanaspa MA, Roncal-Jiménez CA, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sánchez-Lozada LG. Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F727-36. PubMed PMID: 23303409
  • Franco M, Tapia E, Bautista R, Pacheco U, Santamaria J, Quiroz Y, Johnson RJ, Rodriguez-Iturbe B. Impaired pressure natriuresis resulting in salt-sensitive hypertension is caused by tubulointerstitial immune cell infiltration in the kidney. Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F982-90. PubMed PMID: 23364804
  • Feig DI, Madero M, Jalal DI, Sanchez-Lozada LG, Johnson RJ. Uric acid and the origins of hypertension. J Pediatr. 2013 May;162(5):896-902. PubMed PMID: 23403249
  • Hohenstein B, Daniel C, Johnson RJ, Amann KU, Hugo CP. Platelets are not critical effector cells for the time course of murine passive crescentic glomerulonephritis. Platelets. 2013;24(4):267-74. PubMed PMID: 22779773
  • Kanbay M, Segal M, Afsar B, Kang DH, Rodriguez-Iturbe B, Johnson RJ. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart. 2013 Jun;99(11):759-66. PubMed PMID: 23343689
  • Johnson RJ, Stenvinkel P, Martin SL, Jani A, Sánchez-Lozada LG, Hill JO, Lanaspa MA. Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. Obesity (Silver Spring). 2013 Apr;21(4):659-64. PubMed PMID: 23401356
  • Sanchez-Lozada LG, Le M, Segal M, Johnson RJ. How safe is fructose for persons with or without diabetes? Am J Clin Nutr 2008; 88:1189-90.
  • Ishimoto T, Shimada M, Gabriela G, Kosugi T, Sato W, Lee PY, Lanaspa MA, Rivard C, Maruyama S, Garin EH, Johnson RJ. Toll-like receptor 3 ligand, polyIC, induces proteinuria and glomerular CD80, and increases urinary CD80 in mice. Nephrol Dial Transplant. 2013 Jun;28(6):1439-46. PubMed PMID: 23262434
  • Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, Ishimoto T, Sautin YY, Lanaspa MA. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes. 2013 Oct;62(10):3307-15. PubMed PMID: 24065788
  • Reungjui S, Johnson RJ. Response to “Thiazide diuretics: rat versus man”. Kidney Int 2008; 74:831
  • Chen W, Roncal-Jimenez C, Lanaspa M, Smits G, Chonchol M, Johnson RJ, Jalal D. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism 2014 Jan;63(1):150-60
  • Rodriguez-Iturbe B, Pons H, Quiroz Y, Lanaspa MA, Johnson RJ. Autoimmunity in the pathogenesis of hypertension. Nat Rev Nephrol 2014 Jan;63(1):150-60
  • Solak Y, Akilli H, Kayrak M, Aribas A, Galpov A, Turk S, Perez-Pozo SE, Covic A, McFann K, Johnson RJ, Kanbay M. Uric acid level and erectile dysfunction in patients with coronary artery disease: A new link? Journal of Sexual Medicine 2014;11:165–172
  • Tharabenjasin P, Douard V, Patel C, Krishnamara N, Johnson RJ, Zuo J, Ferraris RP. Acute interactions between intestinal sugar and calcium transport in vitro. Am J Physiol Gastroenterol Liver Physiol 2014 Jan;306(1):G1-G12
  • Correa-Rotter R, Wesseling C, Johnson RJ. Chronic Kidney Disease of unknown origin in Central America: the case for a Mesoamerican Nephropathy. Am J Kid Dis 2014; 63(3):506-520.
  • Maeda-Hori M, Kosugi T, Kojima H, Sato W, Inaba S, Maeda K, Nagaya H, Sato Y, Ishimoto T, Ozaki T, Tsuboi N, Muro Y, Yuzawa Y, Imai E, Johnson RJ, Matsuo S, Kadomatsu K, and Maruyama S. Plasma CD147 reflects histological features in patients with lupus nephritis. Lupus 2014; 23:342-352
  • Bjornstad P, Wadwa RP, Sirota JC, Snell-Bergen JK, McFann K, Rewers M, Rivard CJ, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes J Clin Hypertens (Greenwich). 2014 Apr;16(4):283-8)
  • Kratzer J, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher E. Evolutionary history and metabolic insights of ancient mammalian uricases. Proc Natl Acad Sci USA 2014 Mar 11;111(10):3763-8
  • Thomas J, Lanaspa MA, Schreiner G, Johnson RJ. Epicatechin Protects against Corticosteroid Induced Hepatic Steatosis, Journal of Steroids & Hormonal Science 2014; 5:1
  • Kanbay M, Siriopol D, Nistor I, Elcioglu OC, Telci O, Takir M, Johnson RJ, Covic A. Effect of allopurinol on endothelial dysfunction: A Meta-analysis. Am J Nephrol 2014; 39:348-356
  • Zharikov S, Krotova K, Hu H, Baylis C, Johnson RJ, Block ER, Patel JM. Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells. Am J Physiol Cell Physiol 2008; 295:C1183-90.
  • Bjornstad P, Snell Bergeon J,K, McFann K, Wadwa RP, Rivard CJ, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Serum uric acid and insulin sensitivity in adolescents with and without type 1 diabetes. J Diabetes Complications 2014; 16:283-288
  • Vandell AG, McDonough CW, Gong Y, Langaee TY, Lucas AM, Chapman AB, Gums JG, Beitelshees AL, Bailey KR, Johnson RJ, Boerwinkle E, Turner ST, Cooper-DeHoff RM, Johnson JA. Hydrochlorothiazide-Induced Hyperuricemia in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) Study. J Intern Med. 2014 Feb 12. [Epub ahead of print]. PMID: 24612202
  • Kanbay A, Inonu H, Solak Y, Erden A, Uslu E, Yuksel SA, Ozturk MA, McFann K, Johnson RJ, Kanbay M. Uric acid as a potential mediator of cardiovascular morbidity in obstructive sleep apnea syndrome. Eur J Int Med 2014 Jun;25(5):471-6
  • 2. Johnson RJ, Rodriguez-Iturbe B, Roncal-Jimenez C, Lanaspa MA, Ishimoto T, Nakagawa T, Correa-Rotter R, Wesseling C, Bankir L, Sánchez-Lozada LG. Hyperosmolarity drives hypertension and CKD—Water and Salt revisited. Nat Rev Nephrol 2014 Jul;10(7):415-20
  • Roncal-Jimenez, C, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, Gonzalez MA, Aragon A, Wesseling C, Sanchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration induced renal injury. Kidney International 2014; 86:294-302
  • Gersch C, Palii SP, Kim KM, Angerhofer A, Johnson RJ, Henderson GN. Inactivation of nitric oxide by uric acid. Nucleosides Nucleotides Nucleic Acids 2008; 27:967-78.
  • Cara-Fuentes G, Wei C, Alfons S, Ishimoto T, Rivard C, Johnson RJ, Reiser J, Garin EH. CD80 and suPAR in patients with Minimal Change Disease and Focal Segmental Glomerulosclerosis: Diagnostic and Pathogenic Significance. Pediatr Nephrol 2014; 29:1363-71
  • Johnson RJ, Glaser J, Sánchez-Lozada LG. Chronic Kidney Disease of Unknown Etiology: A Disease of Global Warming? MEDICC Review 2014; 16:79-81
  • Becker GJ, Abboud O, Bellerin-Font E, Field M, Li PKT, Johnson RJ, Wanner C. The ISN clinical practice guidelines committee. Nature Medicine Clinical Practice Nephrol 2008; 4:463
  • Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Ishimoto T, Rivard CJ, Sautin YY, Gaucher E, Johnson RJ, Lanaspa MA. Uric Acid-dependent inhibition of AMP Kinase induces hepatic glucose production in diabetes and starvation: Evolutionary Implications of the Uricase loss in hominids. FASEB J 2014; 28:3339-50
  • Turak O, Afsar B, Ozcan F, Canpolat U, Grbovic E, Mendi MA, Oksuz, F, Siriopol D, Covic A, Caliskan M, McFann K, Johnson RJ, Kanbay M. Relationship between Elevated Morning Blood Pressure Surge, Uric Acid and Cardiovascular Outcomes in Hypertensive Patients. J Clin Hypertens 2014; 16:530-535
  • Mohandas R, Sautina L, Beem E, Schuler A, Chan WY, Domsic J, McKenna R, Johnson RJ, Segal MS.Uric Acid Inhibition of Dipeptidyl Peptidase IV In Vitro is Dependent on the Intracellular Formation of Triuret. Exp Cell Res 2014; 326136-142
  • Bjornstad P, Maahs DM, Rivard CJ, Pyle L, Rewers M, Johnson RJ, Snell-Bergeon JK. Serum Uric Acid Predicts Vascular Complications in Adults with Type 1 Diabetes: the Coronary Artery Calcification in Type 1 Diabetes Study. Acta Diabetologia. 2014 Oct;51(5):783-91
  • Cara-Fuentes G, Kairalla J, Ishimoto T, et al. Rituximab in Idiopathic Nephrotic Syndrome: Does it Make Sense? Pediatr Nephrol 2014; 2014 Aug;29(8):1313-9
  • Johnson RJ, Lanaspa MA, Sanchez-Lozada LG, Rivard CJ, Bjornstad P, Merriman TR, Sundborn G. Fat Storage syndrome in Pacific Peoples: A Combination of Environment and Genetics? Public Health Dialogue 2014; 20:11-16
  • Merriman TR, Dalbeth N, Johnson RJ. Sugar-sweetened beverages, genes, urate and gout. Public Health Dialogue 2014; 20:31-38
  • Choi YJ, Shin HS, Choi HS, Park JW, Jo I, Oh ES, Lee KY, Johnson RJ, Kang DH. Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. Lab Invest 2014; 94:1114-25
  • Rodriguez-Iturbe B, Pons H, Quiroz Y, Johnson RJ. The immunological basis of hypertension. Am J Hypertens 2014; 27:1327-37
  • Couser WG, Johnson RJ. The etiology of glomerulonephritis: Roles of infection and autoimmunity. Kidney Int 2014; 86:905-914
  • Lanaspa MA, Ishimoto T, Cicerchi C, Tamura , Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz A, Kitagawa W, Garcia G, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy. JASN 2014;25:2526-38
  • Cara-Fuentes G, Wasserfal CH, Wang H, Johnson RJ, Garin EH. Minimal Change Disease: A dysregulation of the podocyte CD80-CTLA-4 Axis? Pediatric Nephrol 2014; 29: 2333-40
  • Bjornstad P, Maahs D, Rewers M, Johnson RJ, Snell-Bergeon J. ABC goal achievement predicts microvascular but not macrovascular complications over 6-years in adults with type 1 diabetes: the Coronary Artery Calcification in Type 1 Diabetes Study. J Diabetes Complications 2014; 28:762-6
  • Garin EH, Reiser J, Cara-Fuentes G, Wei C, Matar D, Wang H, Alachkar N, Johnson RJ. Case series: CTLA4-IgG1 therapy in minimal change disease and focal segmental glomerulosclerosis. Pediatr Nephrol. 2014 Sep 20. [Epub ahead of print]
  • Shirashi T, Tamura Y, Taniguchi K, HIagaki M, Ueda S, Shima T, Nagura M, Nakagawa T, Johnson RJ, Uchida S. Combination of ACE inhibitor with nicroandil provides further protection in chronic kidney disease. Am J Physiol Renal Physiol 2014; 307:F1313-1322
  • Andrews P, Johnson RJ. Gibbons and hominoid ancestry. In Taxonomic Tapestries: the threads of behavioural, evolutionary and conservation research. Eds AM Behie and MF Oxenham. 2014. London, UK.
  • Wadhwa A, Inaba S, Johnson RJ. Uric acid and hypertension—is there really a link? In Chronic Kidney Disease and Hypertension, Edited by Edgar Lerma and Matt Weir, Springer, 2014
  • Sanchez-Lozada LG, Madero M, Reungjui S, Johnson R.J. Sugars, Fructose, Hypertension and Kidney Disease, in Dietary Sugars and Health, eds Goran MI, Tappy L, Le K-A, and Ulijaszek S, Taylor and Francis, London, 2014.
  • Kang DH, Johnson RJ. Chapter 35. Uric acid metabolism and the Kidney. In Chronic Kidney Disease, eds M Rosenberg and P Kimmel, Elsevier, Philadelphia, 2014
  • Fini MA, Wright RM, Stenmark KR, Daniels SR, Johnson RJ. Metabolically Healthy but Overweight and/or Obese: Is Uric Acid an Underdiagnosed Mediator of Adverse Outcome? Am J Med (letter) 2014;127; e21
  • Jefferson JA, Escudero E, Johnson RJ, Swenson ER, Hurtado A. Increased Oxidative Stress at High altitude. Chest 2014; 145:423
  • Cara-Fuentes G, Johnson RJ, Reiser J, Garin EH. CD80 and suPAR in patients with minimal change disease and focal segmental glomerulosclerosis: diagnostic and pathogenic significance: Response. Pediatr Nephrol. 2014 Aug;29(8):1467-8
  • Parra G, Quiroz Y, Salazar J, Bravo J, Pons H,Chavez M, Johnson RJ, Rodríguez-Iturbe B. Experimental induction of salt sensitive hypertension is associated with lymphocyte proliferative response to HSP70. Kidney Int (suppl) 2008; 111:S55-9
  • Hu H, Lu L, Mu W, Johnson RJ, Block ER, Patel JM. Priming donor lungs with thioredoxin-1 attenuates acute allograft injury in a rat model of lung transplantation. J Heart Lung Transplant 2008; 27:1142-9.
  • Mohandas R, Johnson RJ. Uric acid levels increase risk for new-onset kidney disease. J Am Soc Nephrol 2008; 19:2251-3.
  • Tapia E, Sanchez-Gonzalez DJ, Medina-Campos ON, Soto V, Avila-Casado C, Martinez-Martinez CM, Johnson RJ, Rodriguez-Iturbe B, Pedraza-Chaverri J, Franco M, Sanchez-Lozada LG. Treatment with pyrroldine dithiocarbamate improves proteinuria, oxidative stress and glomerular hypertension in overload proteinuria. Am J Physiol Renal Physiol 2008; 295:F1431-9
  • Garin EH, Diaz LN, Mu W, Wasserfal C, Arraya C, Johnson RJ. Urinary CD80 Excretion Increases in Idiopathic Minimal-Change Disease. J Am Soc Nephrol 2009; 20:260-266
  • Kosugi T, Nakagawa T, Kamath D, Johnson RJ. Uric acid and hypertension: an age-related relationship? J Hum Hypertens 2009; 23:75-6.
  • Johnson RJ, Sautin YY, Oliver WJ, et al. Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? J Comp Physiol [B] 2009;179:67-76.
  • Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, Shafiu M, Segal M, Glassock RJ, Shimada M, Roncal C, Nakagawa T. Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes? Endocr Rev 2009; 30: 96-116
  • Stenvinkel P, Painer J, Kuro-O M, Lanaspa M, Arnold W, Ruf T, Shiels PG, Johnson RJ. Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nat Rev Nephrol. 2018 Jan 15. [Epub ahead of print] PubMed PMID: 29332935
  • Harland TA, Winston KR, Jovanovich AJ, Johnson RJ. Shunt Nephritis: An Increasingly Unfamiliar Diagnosis. World Neurosurg. 2018 Jan 8. [Epub ahead of print] PubMed PMID: 29325951
  • Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, Nakagawa T, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Rodriguez-Iturbe B, Ohno M, Lanaspa MA, Johnson RJ. Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study. Hypertension. 2018 Jan;71(1):78-86. PubMed PMID: 29203632
  • Hurtado-Arestegui A, Plata-Cornejo R, Cornejo A, Mas G, Carbajal L, Sharma S, Swenson ER, Johnson RJ, Pando J. Higher prevalence of unrecognized kidney disease at high altitude. J Nephrol. 2017 Nov 8. [Epub ahead of print] PubMed PMID: 29119539
  • Bjornstad P, Pyle L, Cherney DZI, Johnson RJ, Sippl R, Wong R, Rewers M, Snell-Bergeon JK. Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant. 2017 Aug 21. [Epub ahead of print] PubMed PMID: 28992280
  • Lee SM, Lee AL, Winters TJ, Tam E, Jaleel M, Stenvinkel P, Johnson RJ. Low Serum Uric Acid Level is a Risk Factor for Death in Incident Hemodialysis Patients Am J Nephrol 2009; 29:79-85
  • Chen W, Chen W, Wang H, Dong X, Liu Q, Mao H, Tan J, Lin J, Zhou F, Luo N, He H, Johnson RJ, Yu X. Prevalence and risk factors associated with chronic kidney disease in an adult population from Southern China. Nephrol Dial Transpl (in press, 2009)
  • Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KY, Gesualdo T, Henderson GN, Johnson RJ, Sautin YY. Ketohexokinase-Dependent Metabolism of Fructose Induces Proinflammatory Mediators in Proximal Tubular Cells. J Am Soc Nephrol 2009 (in press).
  • Cirillo P, Sautin YY, Kanellis J, Kang DH, Gesualdo L, Nakagawa T, Johnson RJ. Systemic inflammation, metabolic syndrome, and progressive renal disease. Nephrol Dial Transpl 2009 (in press)
  • Yamada K, Shah JA, Tanabe T, Lanaspa MA, Johnson RJ. Xenotransplantation: Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials. Curr Transplant Rep. 2017 Jun;4(2):101-109. PubMed PMID: 28989853
  • Mu W, Long DA, Ouyang X, Agarwal A, Connor T, Cruz PE, Roncal CA, Johnson RJ. Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism. Am J Physiol Renal Physiol 2009;296:F145-52.
  • Todd AS, Walker RJ, MacGinley RJ, Kelly J, Merriman TR, Major TJ, Johnson RJ. Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans. Am J Hypertens. 2017 Nov 6;30(12):1196-1202. PubMed PMID: 28985270
  • García-Arroyo FE, Tapia E, Blas-Marron MG, Gonzaga G, Silverio O, Cristóbal M, Osorio H, Arellano-Buendía AS, Zazueta C, Aparicio-Trejo OE, Reyes-García JG, Pedraza-Chaverri J, Soto V, Roncal-Jiménez C, Johnson RJ, Sánchez-Lozada LG. Vasopressin Mediates the Renal Damage Induced by Limited Fructose Rehydration in Recurrently Dehydrated Rats. Int J Biol Sci. 2017;13(8):961-975. PubMed PMID: 28924378
  • Kuwabara M, Kuwabara R, Hisatome I, Niwa K, Roncal-Jimenez CA, Bjornstad P, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Ohno M, Hill JO, Lanaspa MA, Johnson RJ. "Metabolically Healthy" Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study. Obesity (Silver Spring). 2017 Nov;25(11):1997-2008. PubMed PMID: 28922565
  • Johnson RJ, Shimada M. Contemporary Management of Hepatitis C in Patients with CKD. Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1563-1565. PubMed PMID: 28882856
  • Sharma S, Gralla J, Ordonez JG, Hurtado ME, Swenson ER, Schoene RB, Kelly JP, Callacondo D, Rivard C, Roncal-Jimenez C, Sirota J, Fuquay R, Jackson BP, Swenson KE, Johnson RJ, Hurtado A, Escudero E. Acetazolamide and N-acetylcysteine in the treatment of chronic mountain sickness (Monge's disease). Respir Physiol Neurobiol. 2017 Dec;246:1-8. PubMed PMID: 28720395
  • Hahn K, Kanbay M, Lanaspa MA, Johnson RJ, Ejaz AA. Serum uric acid and acute kidney injury: A mini review. J Adv Res. 2017 Sep;8(5):529-536. PubMed PMID: 28748118
  • Rodriguez-Iturbe B, Pons H, Johnson RJ. Role of the Immune System in Hypertension. Physiol Rev. 2017 Jul 1;97(3):1127-1164. PubMed PMID: 28566539
  • Feig DI, Kang DH, Johnson RJ. Reply to N Trivedi. N Engl J Med 2009; 360:539-41.
  • Feig DI, Johnson RJ. Allopurinol and the Role of Uric acid in hypertension. Reply to Dr Brinker. JAMA 2009; 301:270-271.
  • Kim KM, Henderson GN, Frye RF, Galloway CD, Brown NJ, Segal MS, Imaran W, Angerhofer A, Johnson RJ. Simultaneous Determination of Uric Acid Metabolites Allantoin, 6-Aminouracil, and Triuret in Human Urine Using Liquid Chromatography-Mass Spectrometry J Chromatogr B Analyt Technol Biomed Life Sci 2009; 877;65-70
  • Johnson RJ, Sánchez-Lozada LG, Andrews P, Lanaspa MA. Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes. Adv Nutr. 2017 May;8(3):412-422. PubMed PMID: 28507007
  • Cara-Fuentes G, Segarra A, Silva-Sanchez C, Wang H, Lanaspa MA, Johnson RJ, Garin EH. Angiopoietin-like-4 and minimal change disease. PLoS One. 2017;12(4):e0176198. PubMed PMID: 28441404
  • Nakayama T, Sato W, Kosugi T, Zhang L, Campbell-Thompson M, Yoshimura A, Croker BP, Johnson RJ, Nakagawa T. Endothelial injury due to eNOS deficiency acclerates the progression of chronic renal disease in the mouse. Am J Physiol Renal Physiol 2009; 296:F317-F27
  • Gersch C, Palii SP, Imaram W, Kim KM, Karumanchi SA, Angerhofer A, Johnson RJ, Henderson GN. Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alklyated products and triuret, and in vivo production of triuret under conditions of oxidative stress. Nucleosides, Nucleotides, and Nucleic Acids. 2009 (in press)
  • Johnson RJ. Pro: Heat stress as a potential etiology of Mesoamerican and Sri Lankan nephropathy: a late night consult with Sherlock Holmes. Nephrol Dial Transplant. 2017 Apr 1;32(4):598-602. PubMed PMID: 28407135
  • Johnson RJ, Tisher CC. Chapter 6. Glomerular diseases. In Handbook of Nephrology and Hypetension, eds CS Wilcox and CC Tisher, 6th edition, Lippincott Williams and Wilkins, Philadelphia, 2008.
  • Johnson RJ. Opponent's comments. Nephrol Dial Transplant. 2017 Apr 1;32(4):606-607. PubMed PMID: 28407134
  • Kuwabara M, Niwa K, Hisatome I, Nakagawa T, Roncal-Jimenez CA, Andres-Hernando A, Bjornstad P, Jensen T, Sato Y, Milagres T, Garcia G, Ohno M, Lanaspa MA, Johnson RJ. Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study. Hypertension. 2017 Jun;69(6):1036-1044. PubMed PMID: 28396536
  • Kuwabara M, Bjornstad P, Hisatome I, Niwa K, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Milagres T, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ. Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function. Am J Nephrol. 2017;45(4):330-337. PubMed PMID: 28285309
  • Andres-Hernando A, Li N, Cicerchi C, Inaba S, Chen W, Roncal-Jimenez C, Le MT, Wempe MF, Milagres T, Ishimoto T, Fini M, Nakagawa T, Johnson RJ, Lanaspa MA. Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice. Nat Commun. 2017 Feb 13;8:14181. PubMed PMID: 28194018
  • Kuwabara M, Sato Y, Kanbay M, Johnson RJ. Uric Acid and Left Ventricular Hypertrophy: A Potentially New Modifiable Target?. Am J Hypertens. 2017 Mar 1;30(3):229-231. PubMed PMID: 28096149
  • Kuwabara M, Hisatome I, Roncal-Jimenez CA, Niwa K, Andres-Hernando A, Jensen T, Bjornstad P, Milagres T, Cicerchi C, Song Z, Garcia G, Sánchez-Lozada LG, Ohno M, Lanaspa MA, Johnson RJ. Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study. PLoS One. 2017;12(1):e0169137. PubMed PMID: 28081152
  • Roncal-Jimenez CA, Milagres T, Andres-Hernando A, Kuwabara M, Jensen T, Song Z, Bjornstad P, Garcia GE, Sato Y, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Effects of exogenous desmopressin on a model of heat stress nephropathy in mice. Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F418-F426. PubMed PMID: 28003190
  • Bjornstad P, Johnson RJ, Snell-Bergeon JK, Pyle L, Davis A, Foster N, Cherney DZ, Maahs DM. Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank. J Diabetes Complications. 2017 Feb;31(2):387-389. PubMed PMID: 27979439
  • Segal MS, Johnson RJ. Chapter 11. Renal Involvement in Systemic Lupus Erythematosus. In Handbook of Nephrology and Hypetension, eds. CS Wilcox and CC Tisher, 6th edition, Lippincott Williams and Wilkins, Philadelphia, 2008.
  • Shafiu M, Johnson RJ. Uric acid, fructose, and the kidney. Handbook of Chronic Kidney Disease Management, 1e JT Daugirdas, MD, editor, Lippincott Williams & Wilkins, Philadelphia, 2009
  • Johnson RJ, Rodriguez-Iturbe B, Bakris GL. Primary hypertension , In Comprehensive Clinical Nephrology, edition 4, Feehally J, Johnson RJ, Floege J. Elsevier 2010
  • Johnson RJ, Floege J, Feehally J. Introduction to Glomerular Disease: Histologic Classi?cation and Pathogenesis. In Comprehensive Clinical Nephrology, edition 4, Feehally J, Johnson RJ, Floege J. Elsevier 2010
  • The Sugar Fix, Rodale, New York, 346 pp
  • Song ??? Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, Oppelt SA, Kuwabara M, Jensen T, Milagres T, Andres-Hernando A, Ishimoto T, Garcia GE, Johnson G, MacLean PS, Sanchez-Lozada LG, Tolan DR, Johnson RJ. Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice. J Neurophysiol. 2017 Feb 1;117(2):646-654. PubMed PMID: 27852737
  • Jalal DI, Decker E, Perrenoud L, Nowak KL, Bispham N, Mehta T, Smits G, You Z, Seals D, Chonchol M, Johnson RJ. Vascular Function and Uric Acid-Lowering in Stage 3 CKD. J Am Soc Nephrol. 2017 Mar;28(3):943-952. PubMed PMID: 27620990
  • Bjornstad P, Pyle L, Kinney GL, Rewers M, Johnson RJ, Maahs DM, Snell-Bergeon JK. Adiponectin is associated with early diabetic kidney disease in adults with type 1 diabetes: A Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. J Diabetes Complications. 2017 Feb;31(2):369-374. PubMed PMID: 27368123
  • Kanbay M, Solak Y, Afsar B, Nistor I, Aslan G, Çaglayan OH, Aykanat A, Donciu MD, Lanaspa MA, Ejaz AA, Johnson RJ, Covic A. Serum Uric Acid and Risk for Acute Kidney Injury Following Contrast. Angiology. 2017 Feb;68(2):132-144. PubMed PMID: 27106252
  • Mendi MA, Afsar B, Oksuz F, Turak O, Yayla C, Ozcan F, Johnson RJ, Kanbay M. Uric Acid is a Useful Tool to Predict Contrast-Induced Nephropathy. Angiology. 2017 Aug;68(7):627-632. PubMed PMID: 27006404
  • Bjornstad P, Wiromrat P, Johnson RJ, Sippl R, Cherney DZ, Wong R, Rewers MJ, Snell-Bergeon JK. Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 years in Adults With Type 1 Diabetes: The CACTI Study. Diabetes Care. 2018 Nov 27. [Epub ahead of print] PubMed PMID: 30482755
  • Rodriguez-Iturbe B, Johnson RJ. Genetic polymorphisms in Hypertension: are we missing the Immune Connection?. Am J Hypertens. 2018 Nov 10. [Epub ahead of print] PubMed PMID: 30418477
  • Johnson RJ, Perez-Pozo SE, Lillo JL, Grases F, Schold JD, Kuwabara M, Sato Y, Hernando AA, Garcia G, Jensen T, Rivard C, Sanchez-Lozada LG, Roncal C, Lanaspa MA. Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress. BMC Nephrol. 2018 Nov 8;19(1):315. PubMed PMID: 30409184
  • Sánchez-Lozada LG, García-Arroyo FE, Gonzaga G, Silverio O, Blas-Marron MG, Muñoz-Jimenez I, Tapia E, Osorio-Alonso H, Madero M, Roncal-Jiménez CA, Weiss I, Glaser J, Johnson RJ. Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate. Am J Nephrol. 2018;48(5):339-348. PubMed PMID: 30391956
  • Dally M, Butler-Dawson J, Krisher L, Monaghan A, Weitzenkamp D, Sorensen C, Johnson RJ, Carlton EJ, Asensio C, Tenney L, Newman LS. The impact of heat and impaired kidney function on productivity of Guatemalan sugarcane workers. PLoS One. 2018;13(10):e0205181. PubMed PMID: 30289894
  • Comprehensive Clinical Nephrology, eds J Feehally, RJ Johnson, J Floege. 1400 pp, Elsevier, Philadelphia
  • Griffin BR, Butler-Dawson J, Dally M, Krisher L, Cruz A, Weitzenkamp D, Sorensen C, Tenney L, Johnson RJ, Newman LS. Unadjusted point of care creatinine results overestimate acute kidney injury incidence during field testing in Guatemala. PLoS One. 2018;13(9):e0204614. PubMed PMID: 30261074
  • Araya CE, Diaz LN, Wasserfall C, Atkinson M, Mu W, Johnson RJ, Garin EH. T regulatory cell function in idiopathic minimal lesion nephrotic syndrome. Pediatr nephrol 2009; 20:260-266
  • Ejaz AA, Martin TD, Johnson RJ, Winterstein AG, Klodell CT, Hess PJ, Ali AK, Whidden WM, Staples NL, Alexander JA, House-Francher MA, Beaver TM. Prophylactic Nesiritide Does Not Prevent Dialysis or All Cause Mortality in patients undegoing High-Risk Cardiac Surgery J Thorac Cardiovas Surgery 2009; 138:959-964
  • Ejaz AA, Beaver TM, Shimada M, Sood P, Lingegowda V, Schold J, Kim T, Johnson RJ. Uric acid: A novel risk factor for acute kidney injury in high risk cardiac surgery patients? Am J Nephrol 2009; 30:425-429
  • Kanbay M, Aslan G, Afsar B, Dagel T, Siriopol D, Kuwabara M, Incir S, Camkiran V, Rodriguez-Iturbe B, Lanaspa MA, Covic A, Johnson RJ. Acute effects of salt on blood pressure are mediated by serum osmolality. J Clin Hypertens (Greenwich). 2018 Oct;20(10):1447-1454. PubMed PMID: 30232829
  • García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Blas-Marron MG, Silverio O, Tapia E, Soto V, Ranganathan N, Ranganathan P, Vyas U, Irvin A, Ir D, Robertson CE, Frank DN, Johnson RJ, Sánchez-Lozada LG. Probiotic supplements prevented oxonic acid-induced hyperuricemia and renal damage. PLoS One. 2018;13(8):e0202901. PubMed PMID: 30142173
  • Jensen T, Niwa K, Hisatome I, Kanbay M, Andres-Hernando A, Roncal-Jimenez CA, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ, Kuwabara M. Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver. Sci Rep. 2018 Aug 6;8(1):11735. PubMed PMID: 30082907
  • Kuwabara M, Kuwabara R, Niwa K, Hisatome I, Smits G, Roncal-Jimenez CA, MacLean PS, Yracheta JM, Ohno M, Lanaspa MA, Johnson RJ, Jalal DI. Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects. Nutrients. 2018 Aug 3;10(8). PubMed PMID: 30081468
  • Jensen T, Bjornstad P, Johnson RJ, Sippl R, Rewers M, Snell-Bergeon JK. Copeptin and Estimated Insulin Sensitivity in Adults With and Without Type 1 Diabetes: The CACTI Study. Can J Diabetes. 2018 Mar 14. [Epub ahead of print] PubMed PMID: 30026043
  • Milagres T, García-Arroyo FE, Lanaspa MA, Garcia G, Ishimoto T, Andres-Hernando A, Kuwabara M, Jensen T, Sato Y, Glaser J, Sánchez-Lozada LG, Johnson RJ, Roncal-Jimenez C. Rehydration with fructose worsens dehydration-induced renal damage. BMC Nephrol. 2018 Jul 13;19(1):180. PubMed PMID: 30005632
  • Johnson RJ. Finding the truth: multivariable analysis and the assassination of Abraham Lincoln. J R Coll Physicians Edinb. 2018 Jun;48(2):153-154. PubMed PMID: 29992207
  • Kuwabara M, Hisatome I, Roncal-Jimenez CA, Niwa K, Andres-Hernando A, Jensen T, Bjornstad P, Milagres T, Cicerchi C, Song Z, Garcia G, Sánchez-Lozada LG, Ohno M, Lanaspa MA, Johnson RJ. Correction: Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study. PLoS One. 2018;13(5):e0197941. PubMed PMID: 29772014
  • Roncal CA, Reungjui S, Sanchez-Lozada LG, Mu W, Sautin YY, Nakagawa T, Johnson RJ. Combination of Captopril and Allopurinol Retards Fructose-Induced Metabolic Syndrome Am J Nephrol 2009; 30:399-404. PMC- 149478
  • Afsar B, Kuwabara M, Ortiz A, Yerlikaya A, Siriopol D, Covic A, Rodriguez-Iturbe B, Johnson RJ, Kanbay M. Salt Intake and Immunity. Hypertension. 2018 Jul;72(1):19-23. PubMed PMID: 29760151
  • Rivard CJ, Tanabe T, Lanaspa MA, Watanabe H, Nomura S, Andres-Hernando A, Garth K, Sekijima M, Ishimoto T, Ariyoshi Y, Garcia GE, Shah J, Lennan B, Tasaki M, Pomposelli T, Shimizu A, Sachs DH, Johnson RJ, Yamada K. Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - an experimental study. Transpl Int. 2018 Oct;31(10):1164-1177. PubMed PMID: 29722117
  • Trostel J, Truong LD, Roncal-Jimenez C, Miyazaki M, Miyazaki-Anzai S, Kuwabara M, McMahan R, Andres-Hernando A, Sato Y, Jensen T, Lanaspa MA, Johnson RJ, Garcia GE. Different effects of global osteopontin and macrophage osteopontin in glomerular injury. Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F759-F768. PubMed PMID: 29717936
  • Johnson RJ, Rodriguez-Iturbe B. Rethinking progression of CKD as a process of punctuated equilibrium. Nat Rev Nephrol. 2018 Jul;14(7):411-412. PubMed PMID: 29717190
  • Shah JA, Lanaspa MA, Tanabe T, Watanabe H, Johnson RJ, Yamada K. Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation. J Immunol Res. 2018;2018:6413012. PubMed PMID: 29687010
  • Rodriguez-Iturbe B, Lanaspa MA, Johnson RJ. The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension. Br J Pharmacol. 2018 Apr 21. [Epub ahead of print] PubMed PMID: 29679484
  • Kosugi T, Nakayama T, Heinig M, Zhang L, Yuzawa Y, Sanchez-Lozada LG, Roncal C, Johnson RJ, Nakagawa T. The Effect of Lowering Uric Acid on Renal Disease in the Type 2 Diabetic db/db Mice. Am J Physiol Renal Physiol 2009; 297:F481-8
  • Johnson RJ. Finding the truth: blind faith and the lemming phenomenon. J R Soc Med. 2018 May;111(5):175-176. PubMed PMID: 29672200
  • Roncal-Jimenez CA, Sato Y, Milagres T, Andres Hernando A, García G, Bjornstad P, Dawson JB, Sorensen C, Newman L, Krisher L, Madero M, Glaser J, Gárcía-Trabanino R, Romero EJ, Song Z, Jensen T, Kuwabara M, Rodriguez-Iturbe B, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Experimental heat stress nephropathy and liver injury are improved by allopurinol. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F726-F733. PubMed PMID: 29667911
  • Doke T, Ishimoto T, Hayasaki T, Ikeda S, Hasebe M, Hirayama A, Soga T, Kato N, Kosugi T, Tsuboi N, Lanaspa MA, Johnson RJ, Kadomatsu K, Maruyama S. Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice. Metabolism. 2018 Aug;85:161-170. PubMed PMID: 29604362
  • Rodríguez-Iturbe B, Johnson RJ. Heat shock proteins and cardiovascular disease. Physiol Int. 2018 Mar 1;105(1):19-37. PubMed PMID: 29602292
  • Kuwabara M, Borghi C, Cicero AFG, Hisatome I, Niwa K, Ohno M, Johnson RJ, Lanaspa MA. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan. Int J Cardiol. 2018 Jun 15;261:183-188. PubMed PMID: 29551256
  • Kim KM, Henderson GN, Ouyang X, Frye RF, Sautin YY, Feig DI, Johnson RJ. A Sensitive and Specific Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Intracellular and Intercellular Uric Acid. J Chromatogr B Analyt Technol Biomed Life Sci 2009; 877:2032-2038
  • Hovind P, Rossing P, Tarnow L, Johnson RJ, Parving HH. Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes – an inception cohort study. Diabetes 2009; 58:1668-71. PMC- 2699868
  • Johnson RJ, Rivard C, Nakagawa T, Sautin YY, Sanvhez-Lozada LG. Uric acid: More to Learn, More Experiments to Do. Am J Hypertens 2009; 22:952-3 (commentary)
  • Shimada M, Johnson RJ, May WS, Lingegowda V, Sood P, Nakagawa T, Van QC, Das B, Ejaz AA. A novel role for uric acid in acute kidney injury associated with tumour lysis syndrome. Nephrol Dial Transpl 2009; 24:2960-4
  • Sánchez-Lozada LG, Mu W, Roncal C, Sautin YY, Abdelmalak M, Reungjui S, Le M, Nakagawa T, Lan HY, Yu X , Johnson RJ. Comparison of Free Fructose and Glucose to Sucrose in the Ability to Cause Fatty Liver. Eur J Nutr 2010 Feb;49(1):1-9
  • Abdel-Hafez M, Shimada M, Lee PY, Johnson RJ, Garin EH. Idiopathic nephrotic syndrome and atopy: Is there a common link? Am J Kid Dis 2009;54(5):945-53
  • Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. J Clin Invest. 2018 Jun 1;128(6):2226-2238. PubMed PMID: 29533924
  • Sánchez-Lozada LG, Roncal C, Soto V, Madero M, Jalal D, Rivard C, Franco M, Feig DI, Nakagawa T, Johnson RJ. Hiperuricemia como factor de riesgo para el desarrollo de hipertensión, daño renal crónico y síndrome metabólico. Archivos Latinoamericanos de Nefrologia Pediatrica" (Latinamerican archives of pediatric nephrology) 2009; 9:3-9.
  • Kazumel R, Mazzali M, Johnson RJ. Could uric acid have a Pathogenic Role in Chronic Allograft Nephropathy? Arab J Nephrol Transpl 2009; 3: 37-41
  • Perez-Pozo S, Schold J, Nakagawa T, Sanchez-Lozada, LG, Johnson RJ, Lopez Lillo J. Excessive Fructose Intake Induces Features of Metabolic Syndrome in Healthy Adult Males: Role of Uric Acid in the Hypertensive Response. Int J Obesity (in press)
  • Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3138-3143. PubMed PMID: 29507217
  • Bjornstad P, Maahs DM, Roncal CA, Snell-Bergeon JK, Shah VN, Milagres T, Ellis SL, Hatch M, Chung LT, Rewers MJ, Garg S, Cherney DZ, Pyle L, Nadeau KJ, Johnson RJ. Role of bicarbonate supplementation on urine uric acid crystals and diabetic tubulopathy in adults with type 1 diabetes. Diabetes Obes Metab. 2018 Jul;20(7):1776-1780. PubMed PMID: 29498467
  • Johnson RJ, Bakris GL, Borghi C, Chonchol MB, Feldman D, Lanaspa MA, Merriman TR, Moe OW, Mount DB, Sanchez Lozada LG, Stahl E, Weiner DE, Chertow GM. Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation. Am J Kidney Dis. 2018 Jun;71(6):851-865. PubMed PMID: 29496260
  • Cara-Fuentes G, Lanaspa MA, Garcia GE, Banks M, Garin EH, Johnson RJ. Urinary CD80: a biomarker for a favorable response to corticosteroids in minimal change disease. Pediatr Nephrol. 2018 Jul;33(7):1101-1103. PubMed PMID: 29492674
  • Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018 May;68(5):1063-1075. PubMed PMID: 29408694
  • King C, Lanaspa MA, Jensen T, Tolan DR, Sánchez-Lozada LG, Johnson RJ. Uric Acid as a Cause of the Metabolic Syndrome. Contrib Nephrol. 2018;192:88-102. PubMed PMID: 29393133
  • Stenvinkel P, Painer J, Kuro-O M, Lanaspa M, Arnold W, Ruf T, Shiels PG, Johnson RJ. Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nat Rev Nephrol. 2018 Apr;14(4):265-284. PubMed PMID: 29332935
  • Harland TA, Winston KR, Jovanovich AJ, Johnson RJ. Shunt Nephritis: An Increasingly Unfamiliar Diagnosis. World Neurosurg. 2018 Mar;111:346-348. PubMed PMID: 29325951
  • Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, Nakagawa T, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Rodriguez-Iturbe B, Ohno M, Lanaspa MA, Johnson RJ. Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study. Hypertension. 2018 Jan;71(1):78-86. PubMed PMID: 29203632
  • Hurtado-Arestegui A, Plata-Cornejo R, Cornejo A, Mas G, Carbajal L, Sharma S, Swenson ER, Johnson RJ, Pando J. Higher prevalence of unrecognized kidney disease at high altitude. J Nephrol. 2018 Apr;31(2):263-269. PubMed PMID: 29119539
  • Bjornstad P, Pyle L, Cherney DZI, Johnson RJ, Sippl R, Wong R, Rewers M, Snell-Bergeon JK. Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant. 2018 Jul 1;33(7):1189-1196. PubMed PMID: 28992280
  • Osterberg KL, Horswill CA, Johnson RJ, Pallardy SE. Carbohydrate exerts a mild influence on fluid retention following exercise-induced dehydration. J Applied Physiology (in press)
  • Johnson RJ, Sanchez-Lozada LG, Rodriguez-Iturbe B. New treatment for systolic blood pressure? Nat Rev Nephrol. 2009 Dec;5(12):675-6
  • Cirillo P, Sautin YY, Johnson RJ. Reply to Dr White. Nephrol Dial Transpl 2009 24: 3257-3258
  • Imaram W, Johnson RJ, Angerhofer A. ESR Spin Trapping of the Reaction Between Urate. 3 and Peroxynitrite: the Hydrogen Adduct. Appl Magnet Reson (in press)
  • Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR. Fructose and hepatic insulin resistance. Crit Rev Clin Lab Sci. 2020 Jan 14;:1-15. [Epub ahead of print] PubMed PMID: 31935149
  • Aslan G, Afsar B, Sag AA, Camkiran V, Erden N, Yilmaz S, Siriopol D, Incir S, You Z, Garcia ML, Covic A, Cherney DZI, Johnson RJ, Kanbay M. The Effect of Urine pH and Urinary Uric Acid Levels on the Development of Contrast Nephropathy. Kidney Blood Press Res. 2019 Dec 20;:1-11. [Epub ahead of print] PubMed PMID: 31865342
  • Joosten LAB, Crisan TO, Bjornstad P, Johnson RJ. Asymptomatic hyperuricaemia: a silent activator of the innate immune system. Nat Rev Rheumatol. 2019 Dec 10. [Epub ahead of print] PubMed PMID: 31822862
  • García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Corrigendum to "Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages" [Free Radic. Biol. Med. 141 (2019) 182-191]. Free Radic Biol Med. 2019 Dec 5. [Epub ahead of print] PubMed PMID: 31813623
  • Thornley S, King R, Marshall R, Oakley A, Sundborn G, Harrower J, Reynolds E, Arbuckle M, Johnson RJ. How strong is the relationship between scabies and acute rheumatic fever? An analysis of neighbourhood factors. J Paediatr Child Health. 2019 Nov 27. [Epub ahead of print] PubMed PMID: 31774599
  • Zharikov SI, Swenson ER, Block ER, Patel, JM, Johnson RJ. Pulmonary Hypertension and Hyperuricemia: Association with Features of the Metabolic Syndrome. Medical Hypotheses (in press)
  • García-Arroyo FE, Muñoz-Jiménez I, Gonzaga G, Tapia E, Osorio-Alonso H, Roncal-Jiménez CA, Iroz A, Vecchio M, Reyes-García JG, Johnson RJ, Sánchez-Lozada LG. A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose. Int J Mol Sci. 2019 Nov 16;20(22). PubMed PMID: 31744099
  • Jalal DI, Rivard CJ, Johnson RJ, Maahs DM, Rewers M, Snell-Bergeon JK. Serum Uric Acid Levels Predict the Development of Albuminuria over 6 years in Patients with Type 1 Diabetes. Findings from the Coronary Artery Calcification in Type 1 Diabetes study. Nephrol Dial Transpl (in press)
  • Abdelmalek MF, Suzuki A, Guy C, Unalp-Arida C, Colvin R, Johnson RJ, Diehl AM.. Increased fructose consumption is associated with fibrosis severity in patients with NAFLD. Hepatology (in press)
  • Brigham MD, Milgroom A, Lenco MO, Tudor T, Kent JD, LaMoreaux B, Johnson RJ, Mandell BF, Hadker N, Francis K, Sanchez H, Radeck LP, Li JW. Prevalence of Gout in the Surviving United States Solid Organ Transplantation Population. Transplant Proc. 2019 Dec;51(10):3449-3455. PubMed PMID: 31733798
  • Nakayama T, Kosugi T, Connor T, Gersch M, Sanchez-Lozada LG, Roncal C, Perez-Pozo, SE, Johnson RJ, Nakagawa T. Dietary Fructose Causes Tubulointerstitial Injury In The Normal Rat Kidney Am J Physiol. (in press)
  • Andrews P, Johnson RJ. Evolutionary basis for the human diet: consequences for human health. J Intern Med. 2019 Nov 16. [Epub ahead of print] PubMed PMID: 31733113
  • Stenvinkel P, Painer J, Johnson RJ, Natterson-Horowitz B. Biomimetics - Nature's roadmap to insights and solutions for burden of lifestyle diseases. J Intern Med. 2019 Oct 22. [Epub ahead of print] PubMed PMID: 31639885
  • Johnson RJ, Stenvinkel P, Andrews P, Sánchez-Lozada LG, Nakagawa T, Gaucher E, Andres-Hernando A, Rodriguez-Iturbe B, Jimenez CR, Garcia G, Kang DH, Tolan DR, Lanaspa MA. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med. 2019 Oct 17. [Epub ahead of print] PubMed PMID: 31621967
  • García-Arroyo FE, Monroy-Sánchez F, Muñoz-Jiménez I, Gonzaga G, Andrés-Hernando A, Zazueta C, Juárez-Rojas JG, Lanaspa MA, Johnson RJ, Sánchez-Lozada LG. Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats. Biomolecules. 2019 Oct 11;9(10). PubMed PMID: 31614639
  • Yu, MA, Sanchez-Lozada LG, Johnson RJ, Kang DH. Uric Acid : An Inducer of Oxidative Stress and the Renin-Angiotensin System in Human Vascular Endothelial Cells . J Hypertens (in press)
  • Ko J, Kang HJ, Kim DA, Kim MJ, Ryu ES, Lee S, Ryu JH, Roncal C, Johnson RJ, Kang DH. Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding. FASEB J. 2019 Dec;33(12):13334-13345. PubMed PMID: 31553887
  • Isom R, Shoor S, Higgins J, Cara-Fuentes G, Johnson RJ. Abatacept in Steroid-Dependent Minimal Change Disease and CD80-uria. Kidney Int Rep. 2019 Sep;4(9):1349-1353. PubMed PMID: 31517155
  • Bursill D, Taylor WJ, Terkeltaub R, Abhishek A, So AK, Vargas-Santos AB, Gaffo AL, Rosenthal A, Tausche AK, Reginato A, Manger B, Sciré C, Pineda C, van Durme C, Lin CT, Yin C, Albert DA, Biernat-Kaluza E, Roddy E, Pascual E, Becce F, Perez-Ruiz F, Sivera F, Lioté F, Schett G, Nuki G, Filippou G, McCarthy G, da Rocha Castelar Pinheiro G, Ea HK, Tupinambá HA, Yamanaka H, Choi HK, Mackay J, ODell JR, Vázquez Mellado J, Singh JA, Fitzgerald JD, Jacobsson LTH, Joosten L, Harrold LR, Stamp L, Andrés M, Gutierrez M, Kuwabara M, Dehlin M, Janssen M, Doherty M, Hershfield MS, Pillinger M, Edwards NL, Schlesinger N, Kumar N, Slot O, Ottaviani S, Richette P, MacMullan PA, Chapman PT, Lipsky PE, Robinson P, Khanna PP, Gancheva RN, Grainger R, Johnson RJ, Te Kampe R, Keenan RT, Tedeschi SK, Kim S, Choi SJ, Fields TR, Bardin T, Uhlig T, Jansen T, Merriman T, Pascart T, Neogi T, Klück V, Louthrenoo W, Dalbeth N. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. Ann Rheum Dis. 2019 Nov;78(11):1592-1600. PubMed PMID: 31501138
  • Al-Ozairi E, Rivard CJ, Sanchez Lozada LG, Lanaspa MA, Bjornstad P, Al Salem D, Alhubail A, Megahed A, Kuwabara M, Johnson RJ, Asad RA. Fructose tolerance test in obese people with and without type 2 diabetes. J Diabetes. 2019 Aug 31. [Epub ahead of print] PubMed PMID: 31472036
  • Wiromrat P, Bjornstad P, Vinovskis C, Chung LT, Roncal C, Pyle L, Lanaspa MA, Johnson RJ, Cherney DZ, Reznick-Lipina TK, Bishop F, Maahs DM, Wadwa RP. Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes. Pediatr Diabetes. 2019 Dec;20(8):1110-1117. PubMed PMID: 31433534
  • Todd AS, MacGinley RJ, Schollum JBW, Johnson RJ, Williams SM, Sutherland WHF, Mann JI, Walker RJ. Dietary Salt Loading Leads to a Deterioration in Arterial Vascular Reactivity. Am J Clin Nutr (in press)
  • Jalal DI, Smits G, Johnson RJ, Chonchol M. Increased Fructose Intake is Independently Associated with Elevated Blood Pressure. Findings from the National Health and Nutrition Examination Survey (2003-2006). J Am Soc Nephrol (in press)
  • Johnson RJ, Wesseling C, Newman LS. Chronic Kidney Disease of Unknown Cause in Agricultural Communities. Reply. N Engl J Med. 2019 Aug 15;381(7):689. PubMed PMID: 31412197
  • Johnson RJ, Murray R. Fructose, exercise and health. Current Sports Medicine Reports (in press)
  • Andres-Hernando A, Lanaspa MA, Kuwabara M, Orlicky DJ, Cicerchi C, Bales E, Garcia GE, Roncal-Jimenez CA, Sato Y, Johnson RJ. Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F941-F948. PubMed PMID: 31411075
  • Johnson RJ, Andrews P, Benner SA, Oliver W. The evolution of obesity: Insights from the mid Miocene Trans Am Climatol Assoc (in press)
  • Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ. Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1111-F1121. PubMed PMID: 31390229
  • Kanbay M, Yilmaz S, Dincer N, Ortiz A, Sag AA, Covic A, Sánchez-Lozada LG, Lanaspa MA, Cherney DZI, Johnson RJ, Afsar B. Antidiuretic Hormone and Serum Osmolarity Physiology and Related Outcomes: What Is Old, What Is New, and What Is Unknown?. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5406-5420. PubMed PMID: 31365096
  • Sato Y, Feig DI, Stack AG, Kang DH, Lanaspa MA, Ejaz AA, Sánchez-Lozada LG, Kuwabara M, Borghi C, Johnson RJ. The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD. Nat Rev Nephrol. 2019 Dec;15(12):767-775. PubMed PMID: 31296965
  • Hayasaki T, Ishimoto T, Doke T, Hirayama A, Soga T, Furuhashi K, Kato N, Kosugi T, Tsuboi N, Lanaspa MA, Johnson RJ, Maruyama S, Kadomatsu K. Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase. J Nutr Biochem. 2019 Sep;71:54-62. PubMed PMID: 31276916
  • Mazzali M, Kanbay M, Segal MS, Shafiu M, Jalal D, Feig DI, Johnson RJ. Uric acid and hypertension: Cause or Effect? Current Rheumatol Reports (in press)
  • Brigham MD, Radeck LP, Mendonca CM, Lang I, Li JW, Kent JD, LaMoreaux B, Mandell BF, Johnson RJ. Gout Severity in Recipients of Kidney Transplant. Transplant Proc. 2019 Jul - Aug;51(6):1816-1821. PubMed PMID: 31256872
  • Wiromrat P, Bjornstad P, Roncal C, Pyle L, Johnson RJ, Cherney DZ, Lipina T, Bishop F, Maahs DM, Wadwa RP. Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes. J Diabetes Complications. 2019 Sep;33(9):648-650. PubMed PMID: 31253490
  • García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages. Free Radic Biol Med. 2019 Sep;141:182-191. PubMed PMID: 31212064
  • Johnson RJ, Sánchez-Lozada LG, Newman LS, Lanaspa MA, Diaz HF, Lemery J, Rodriguez-Iturbe B, Tolan DR, Butler-Dawson J, Sato Y, Garcia G, Hernando AA, Roncal-Jimenez CA. Climate Change and the Kidney. Ann Nutr Metab. 2019;74 Suppl 3:38-44. PubMed PMID: 31203298
  • Johnson RJ, Rodriguez-Iturbe B, Bakris GL. Primary hypertension , In Comprehensive Clinical Nephrology, edition 4, Feehally J, Johnson RJ, Floege J. Elsevier 2010
  • Andres-Hernando A, Johnson RJ, Lanaspa MA. Endogenous fructose production: what do we know and how relevant is it?. Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):289-294. PubMed PMID: 31166222
  • Hooper PL, Swenson ER, Johnson RJ. Carbonic Anhydrase Inhibitors for the Treatment of High-Altitude Hypoxemia. Am J Med. 2019 Nov;132(11):e799-e800. PubMed PMID: 31152716
  • Johnson RJ, Choi HK, Yeo AE, Lipsky PE. Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout. Hypertension. 2019 Jul;74(1):95-101. PubMed PMID: 31079535
  • Johnson RJ, Wesseling C, Newman LS. Chronic Kidney Disease of Unknown Cause in Agricultural Communities. N Engl J Med. 2019 May 9;380(19):1843-1852. PubMed PMID: 31067373
  • Johnson RJ, Floege J, Feehally J. Introduction to Glomerular Disease: Histologic Classi?cation and Pathogenesis. In Comprehensive Clinical Nephrology, edition 4, Feehally J, Johnson RJ, Floege J. Elsevier 2010
  • Sundborn G, Thornley S, Merriman TR, Lang B, King C, Lanaspa MA, Johnson RJ. Are Liquid Sugars Different from Solid Sugar in Their Ability to Cause Metabolic Syndrome?. Obesity (Silver Spring). 2019 Jun;27(6):879-887. PubMed PMID: 31054268
  • Nakagawa T, Lanaspa MA, Johnson RJ. The effects of fruit consumption in patients with hyperuricaemia or gout. Rheumatology (Oxford). 2019 Jul 1;58(7):1133-1141. PubMed PMID: 31004140
  • Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 Jun;33(6):434-436. PubMed PMID: 31003921
  • Butler-Dawson J, Krisher L, Yoder H, Dally M, Sorensen C, Johnson RJ, Asensio C, Cruz A, Johnson EC, Carlton EJ, Tenney L, Asturias EJ, Newman LS. Evaluation of heat stress and cumulative incidence of acute kidney injury in sugarcane workers in Guatemala. Int Arch Occup Environ Health. 2019 Oct;92(7):977-990. PubMed PMID: 30997573
  • Ejaz AA, Johnson RJ, Shimada M, Mohandas R, Alquadan KF, Beaver TM, Lapsia V, Dass B. The Role of Uric Acid in Acute Kidney Injury. Nephron. 2019;142(4):275-283. PubMed PMID: 30991383
  • James WPT, Johnson RJ, Speakman JR, Wallace DC, Frühbeck G, Iversen PO, Stover PJ. Nutrition and its role in human evolution. J Intern Med. 2019 May;285(5):533-549. PubMed PMID: 30772945
  • Sánchez-Lozada LG, Roncal-Jimenez CA, García-Arroyo FE, Jensen T, Lanaspa MA, Johnson RJ. The perils of rehydrating with soft drinks following heat and exercise. Am J Physiol Regul Integr Comp Physiol. 2019 Mar 1;316(3):R187-R188. PubMed PMID: 30673300
  • Sanchez-Lozada LG, Andres-Hernando A, Garcia-Arroyo FE, Cicerchi C, Li N, Kuwabara M, Roncal-Jimenez CA, Johnson RJ, Lanaspa MA. Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. J Biol Chem. 2019 Mar 15;294(11):4272-4281. PubMed PMID: 30651350
  • Eren OC, Ortiz A, Afsar B, Covic A, Kuwabara M, Lanaspa MA, Johnson RJ, Kanbay M. Multilayered Interplay Between Fructose and Salt in Development of Hypertension. Hypertension. 2019 Feb;73(2):265-272. PubMed PMID: 30595116
  • Pichler R Hugo CH, Johnson RJ. Aging and the Kidney. In Comprehensive Clinical Nephrology, edition 4, Feehally J, Johnson RJ, Floege J. 4th edition, Elsevier 2010
  • Sorensen CJ, Butler-Dawson J, Dally M, Krisher L, Griffin BR, Johnson RJ, Lemery J, Asensio C, Tenney L, Newman LS. Risk Factors and Mechanisms Underlying Cross-Shift Decline in Kidney Function in Guatemalan Sugarcane Workers. J Occup Environ Med. 2019 Mar;61(3):239-250. PubMed PMID: 30575695
  • Kuwabara M, Chintaluru Y, Kanbay M, Niwa K, Hisatome I, Andres-Hernando A, Roncal-Jimenez C, Ohno M, Johnson RJ, Lanaspa MA. Fasting blood glucose is predictive of hypertension in a general Japanese population. J Hypertens. 2019 Jan;37(1):167-174. PubMed PMID: 30507865
  • Bjornstad P, Wiromrat P, Johnson RJ, Sippl R, Cherney DZI, Wong R, Rewers MJ, Snell-Bergeon JK. Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 Years in Adults With Type 1 Diabetes: The CACTI Study. Diabetes Care. 2019 Feb;42(2):297-302. PubMed PMID: 30482755
  • Rodriguez-Iturbe B, Johnson RJ. Genetic Polymorphisms in Hypertension: Are We Missing the Immune Connection?. Am J Hypertens. 2019 Jan 15;32(2):113-122. PubMed PMID: 30418477
  • Jensen T, Bjornstad P, Johnson RJ, Sippl R, Rewers M, Snell-Bergeon JK. Copeptin and Estimated Insulin Sensitivity in Adults With and Without Type 1 Diabetes: The CACTI Study. Can J Diabetes. 2019 Feb;43(1):34-39. PubMed PMID: 30026043
  • Rodriguez-Iturbe B, Lanaspa MA, Johnson RJ. The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension. Br J Pharmacol. 2019 Jun;176(12):1829-1838. PubMed PMID: 29679484
  • Sautin YY, Imaram W, Kim KY, Angerhofer A, Henderson GN, Johnson RJ. Uric acid and oxidative stress. In Oxidative Stress in Applied Basic Research and Clinical Practice: Renal Disorders, and the publisher is The Humana Press / Springer Science, 2010
  • Current Comprehensive Clinical Nephrology (eds Juergen Floege, RJ Johnson and John Feehally), Elsevier, Philadelphia USA, 1500 pages, 2010
  • 426. Jalal DI, Smits G, Johnson RJ, Chonchol M. Increased Fructose Associates with Elevated Blood Pressure. Findings from the National Health and Nutrition Examination Survey (2003-2006). J Am Soc Nephrol 2010 Sep;21(9):1543-9
  • 429. Garin EH, Mu W, Arthur JM, Araya C, Shimada M, Johnson RJ. Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis. Kidney Int 2010 Aug;78(3):296-302
  • Piani F, Melena I, Tommerdahl KL, Nokoff N, Nelson RG, Pavkov ME, van Raalte DH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P. Sex-related differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications. J Diabetes Complications. 2020 Dec 31;:107841. [Epub ahead of print] PubMed PMID: 33423908
  • Piani F, Johnson RJ. Does gouty nephropathy exist, and is it more common than we think?. Kidney Int. 2021 Jan;99(1):31-33. PubMed PMID: 33390238
  • Floege J, Johnson RJ. Hyperuricemia and progression of chronic kidney disease: to treat or not to treat?. Kidney Int. 2021 Jan;99(1):14-16. PubMed PMID: 33390225
  • Maier S, Wieland A, Cree-Green M, Nadeau K, Sullivan S, Lanaspa MA, Johnson RJ, Jensen T. Lean NAFLD: an underrecognized and challenging disorder in medicine. Rev Endocr Metab Disord. 2021 Jan 3. [Epub ahead of print] PubMed PMID: 33389543
  • García-Arroyo FE, Tapia E, Muñoz-Jiménez I, Gonzaga-Sánchez G, Arellano-Buendía AS, Osorio-Alonso H, Manterola-Romero L, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage. Oxid Med Cell Longev. 2020;2020:8850266. PubMed PMID: 33354281
  • Andres-Hernando A, Jensen TJ, Kuwabara M, Orlicky DJ, Cicerchi C, Li N, Roncal-Jimenez CA, Garcia GE, Ishimoto T, Maclean PS, Bjornstad P, Sanchez-Lozada LG, Kanbay M, Nakagawa T, Johnson RJ, Lanaspa MA. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. JCI Insight. 2021 Jan 11;6(1). PubMed PMID: 33320834
  • 430. Johnson RJ, Murray R. Fructose, exercise and health. Current Sports Medicine Reports 2010 Jul-Aug;9(4):253-8
  • Johnson RJ, Lanaspa MA, Fox JW. Upper Paleolithic Figurines Showing Women with Obesity may Represent Survival Symbols of Climatic Change. Obesity (Silver Spring). 2020 Dec 1. [Epub ahead of print] PubMed PMID: 33258218
  • Ebert T, Painer J, Bergman P, Qureshi AR, Giroud S, Stalder G, Kublickiene K, Göritz F, Vetter S, Bieber C, Fröbert O, Arnemo JM, Zedrosser A, Redtenbacher I, Shiels PG, Johnson RJ, Stenvinkel P. Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears. Sci Rep. 2020 Nov 23;10(1):20323. PubMed PMID: 33230252
  • Li JW, Yin D, Wang Z, Brigham MD, LaMoreaux BD, Kent JD, Francis-Sedlak M, Johnson RJ, Hadker N, Francis KM, Sanchez HA, Miyasato G. New-Onset Gout as an Independent Risk Factor for Returning to Dialysis After Kidney Transplantation. Transplant Direct. 2020 Dec;6(12):e634. PubMed PMID: 33225059
  • 431. Johnson RJ, Andrews P, Benner SA, Oliver W. Theodore E Woodward Award. The evolution of obesity: Insights from the mid Miocene. Trans Am Clin Climatol Assoc. 2010;121:295-305
  • 433. Imaram W, Gersch C, Kim KM, Johnson RJ, Henderson GN, Angerhofer A. Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry. Free Radical Biol and Medicine 2010 Jul 15;49(2):275-81
  • Kang DH, Sanchez-Lozada LG, Johnson RJ. Allopurinol and Chronic Kidney Disease. N Engl J Med. 2020 Oct 22;383(17):1687-1688. PubMed PMID: 33085871
  • 434. Johnson RJ, Andrews P. Fructose, Uricase and the ‘Back to Africa’ Hypothesis. Evolutionary Anthropol 2010; 19:250-257
  • Johnson RJ, Gomez-Pinilla F, Nagel M, Nakagawa T, Rodriguez-Iturbe B, Sanchez-Lozada LG, Tolan DR, Lanaspa MA. Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer's Disease. Front Aging Neurosci. 2020;12:560865. PubMed PMID: 33024433
  • 435. Li Q, Verma A, Han PY, Nakagawa T, Johnson RJ, Grant MB, Campbell-Thompson M, Jarajapu YP, Lei B, Hauswirth WW. Diabetic eNOS knockout mice developed advanced retinopathy. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5240-6010
  • 436. Imaram W, Johnson RJ, Angerhofer A. ESR Spin Trapping of the Reaction Between Urate. 3 and Peroxynitrite: the Hydrogen Adduct. Appl Magnet Reson 2010,37: 463-472
  • Khanna P, Johnson RJ, Marder B, LaMoreaux B, Kumar A. Systemic Urate Deposition: An Unrecognized Complication of Gout?. J Clin Med. 2020 Oct 3;9(10). PubMed PMID: 33023045
  • 437. Rodrigues TC, Maahs DM, Johnson RJ, Jalal D, Kinney GL, Rivard C, Rewers M, Snell-Bergeon JK. Serum Uric Acid Predicts Progression of Subclinical Coronary Atherosclerosis in Individuals without Renal Disease. Diabetes Care 2010; 33:2471-3
  • Dally M, Butler-Dawson J, Johnson RJ, Krisher L, Jaramillo D, Newman KL, Newman LS. Creatinine Fluctuations Forecast Cross-Harvest Kidney Function Decline Among Sugarcane Workers in Guatemala. Kidney Int Rep. 2020 Sep;5(9):1558-1566. PubMed PMID: 32954081
  • 438. Goldberg R, Nakagawa T, Johnson RJ, Thurman J. The role of endothelial cell injury in thrombotic microangiopathy. Am J Kid Dis 2010 ;56:1168-74
  • 439. Rodriguez-Iturbe B, Johnson RJ. The role of renal microvascular disease and interstitial inflammation in salt- sensitive hypertension. Hypertens Res 2010; 33:975-80
  • Schaeffer JW, Adgate JL, Reynolds SJ, Butler-Dawson J, Krisher L, Dally M, Johnson RJ, James KA, Jaramillo D, Newman LS. A Pilot Study to Assess Inhalation Exposures among Sugarcane Workers in Guatemala: Implications for Chronic Kidney Disease of Unknown Origin. Int J Environ Res Public Health. 2020 Aug 7;17(16). PubMed PMID: 32784623
  • 440. Nakagawa T, Reungjui S, Segal M, Johnson RJ. Is There a Dark Side to the Use of Thiazides in Subjects with Chronic Kidney Disease? Nature Reviews Nephrology 2010; 6:564-6
  • Borghi C, Agabiti-Rosei E, Johnson RJ, Kielstein JT, Lurbe E, Mancia G, Redon J, Stack AG, Tsioufis KP. Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease. Eur J Intern Med. 2020 Oct;80:1-11. PubMed PMID: 32739239
  • 441. Nakagawa T, Sanchez-Lozada LG, Johnson RJ. The effect of fructose on renal biology and disease. J Am Soc Nephrol 2010; 21:2036-9
  • Vinovskis C, Li LP, Prasad P, Tommerdahl K, Pyle L, Nelson RG, Pavkov ME, van Raalte D, Rewers M, Pragnell M, Mahmud FH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P. Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes. Diabetes. 2020 Dec;69(12):2700-2708. PubMed PMID: 32737116
  • Stenvinkel P, Shiels PG, Painer J, Miranda JJ, Natterson-Horowitz B, Johnson RJ. A planetary health perspective for kidney disease. Kidney Int. 2020 Aug;98(2):261-265. PubMed PMID: 32709283
  • Nakagawa T, Lanaspa MA, Millan IS, Fini M, Rivard CJ, Sanchez-Lozada LG, Andres-Hernando A, Tolan DR, Johnson RJ. Fructose contributes to the Warburg effect for cancer growth. Cancer Metab. 2020;8:16. PubMed PMID: 32670573
  • Stenvinkel P, Painer J, Shiels PG, Bansal A, Fereidouni S, Natterson-Horowitz B, Johnson RJ, Miranda JJ. SARS-COV-2 and biomimetics: What saves the planet will save our health. J Intern Med. 2020 Jun 24. [Epub ahead of print] PubMed PMID: 32583447
  • Andres-Hernando A, Kuwabara M, Orlicky DJ, Vandenbeuch A, Cicerchi C, Kinnamon SC, Finger TE, Johnson RJ, Lanaspa MA. Sugar causes obesity and metabolic syndrome in mice independently of sweet taste. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E276-E290. PubMed PMID: 32574112
  • 442. Nakagawa T, Tanabe K, Croker BP, Johnson RJ, Grant MA, Kosugi T, Li Q. Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nature Rev Nephrol 2011; 7:36-44
  • 443. Hovind P, Rossing P, Johnson RJ, Parving HH. Serum uric acid as a new player in the development of diabetic nephropathy. J Renal Nutr (review) 2011; 21: 124–127
  • 444. Chen W, Wang H, Liu Q, Chen W, Johnson RJ, Dong X, Li H, Sangba, Tan J, Luo N, He H,Yu X. Prevalence and risk factors of chronic kidney disease: a population study in the Tibetan population. Nephrol Dial Transpl (in press)
  • 445. Kanbay M, Sanchez-Lozada LG, Franco M, Madero M, Solak Y, Rodriguez-Iturbe, B, Covic A, Johnson RJ. Microvascular Disease and Its Role In Brain And Cardiovascular System: A Potential Role For Uric Acid As A Cardiorenal Toxin. Nephrol Dial Transpl (in press)
  • 446. Perez-Pozo SE, Schold J, Nakagawa T, Sanchez-Lozada LG, Johnson RJ, Lopez-Lillo J. Response to Dr White. Int J Obes (Lond). 2010 Sep 21(in press)
  • Andres-Hernando A, Orlicky DJ, Kuwabara M, Ishimoto T, Nakagawa T, Johnson RJ, Lanaspa MA. Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction. Cell Metab. 2020 Jul 7;32(1):117-127.e3. PubMed PMID: 32502381
  • Hansson E, Glaser J, Jakobsson K, Weiss I, Wesseling C, Lucas RAI, Wei JLK, Ekström U, Wijkström J, Bodin T, Johnson RJ, Wegman DH. Pathophysiological Mechanisms by which Heat Stress Potentially Induces Kidney Inflammation and Chronic Kidney Disease in Sugarcane Workers. Nutrients. 2020 Jun 2;12(6). PubMed PMID: 32498242
  • Aguilar-Ramirez D, Raña-Custodio A, Villa A, Rubilar X, Olvera N, Escobar A, Johnson RJ, Sanchez-Lozada L, Obrador GT, Madero M. Decreased kidney function and agricultural work: a cross-sectional study in middle-aged adults from Tierra Blanca, Mexico. Nephrol Dial Transplant. 2020 May 22. [Epub ahead of print] PubMed PMID: 32443156
  • Kuwabara M, Kanbay M, Niwa K, Ae R, Andres-Hernando A, Roncal-Jimenez CA, Garcia G, Sánchez-Lozada LG, Rodriguez-Iturbe B, Hisatome I, Lanaspa MA, Johnson RJ. Hyperosmolarity and Increased Serum Sodium Concentration Are Risks for Developing Hypertension Regardless of Salt Intake: A Five-Year Cohort Study in Japan. Nutrients. 2020 May 14;12(5). PubMed PMID: 32423124
  • Cara-Fuentes G, Venkatareddy M, Verma R, Segarra A, Cleuren AC, Martínez-Ramos A, Johnson RJ, Garg P. Glomerular endothelial cells and podocytes can express CD80 in patients with minimal change disease during relapse. Pediatr Nephrol. 2020 Oct;35(10):1887-1896. PubMed PMID: 32399663
  • Phadke G, Kaushal A, Tolan DR, Hahn K, Jensen T, Bjornstad P, Roncal-Jimenez C, Hernando AA, Lanaspa MA, Alexander MP, Kukla A, Johnson RJ. Osmotic Nephrosis and Acute Kidney Injury Associated With SGLT2 Inhibitor Use: A Case Report. Am J Kidney Dis. 2020 Jul;76(1):144-147. PubMed PMID: 32387022
  • Sato Y, Feig DI, Stack AG, Kang DH, Lanaspa MA, Ejaz AA, Sánchez-Lozada LG, Kuwabara M, Borghi C, Johnson RJ. Reply to 'The case for evidence-based medicine for the association between hyperuricaemia and CKD'. Nat Rev Nephrol. 2020 Jul;16(7):422-423. PubMed PMID: 32313213
  • Li JW, Suh M, Brigham MD, Kent JD, LaMoreaux B, Johnson RJ, Mandell BF, Hadker N, Sanchez H, Francis K, Miyasato G. A Retrospective Cohort Study of the Effect of Gout on Mortality Among Patients with a History of Kidney Transplantation. Ann Transplant. 2020 Apr 14;25:e920553. PubMed PMID: 32284525
  • Nakagawa T, Johnson RJ, Andres-Hernando A, Roncal-Jimenez C, Sanchez-Lozada LG, Tolan DR, Lanaspa MA. Fructose Production and Metabolism in the Kidney. J Am Soc Nephrol. 2020 May;31(5):898-906. PubMed PMID: 32253274
  • Kuwabara M, Hisatome I, Niwa K, Bjornstad P, Roncal-Jimenez CA, Andres-Hernando A, Kanbay M, Johnson RJ, Lanaspa MA. The Optimal Range of Serum Uric Acid for Cardiometabolic Diseases: A 5-Year Japanese Cohort Study. J Clin Med. 2020 Mar 30;9(4). PubMed PMID: 32235468
  • 447. Shimada M, Araya C, Ishimoto T, Johnson RJ, Garin EH. Minimal change disease: a "two-hit" podocyte immune disorder? Pediatr Nephrol (in press)
  • Kuwabara M, Borghi C, Johnson RJ. Febuxostat and atrial fibrillation. Eur Heart J. 2020 Aug 7;41(30):2916-2917. PubMed PMID: 32227166
  • Brigham MD, Milgroom A, Lenco MO, Wang Z, Kent JD, LaMoreaux B, Johnson RJ, Mandell BF, Hadker N, Sanchez H, Francis K, Radeck LP, Miyasato G, Li JW. Immunosuppressant Use and Gout in the Prevalent Solid Organ Transplantation Population. Prog Transplant. 2020 Jun;30(2):103-110. PubMed PMID: 32208882
  • 448. Madero M, Perez-Pozo SE, Jalal D, Johnson RJ, Sanchez-Lozada LG. Dietary fructose and hypertension. Curr Hypertens Reports. 2010 (in press)
  • 449. Lanaspa MA, Sautin YY, Ejaz AA, Madero M, Le M, Manitius J, Sanchez-Lozada LG, Nakagawa T, Johnson RJ. Uric acid and metabolic syndrome: What is the relationship? Current Rheumatol Reviews 2011; 7:xx-xx
  • Sanchez-Lozada LG, Rodriguez-Iturbe B, Kelley EE, Nakagawa T, Madero M, Feig DI, Borghi C, Piani F, Cara-Fuentes G, Bjornstad P, Lanaspa MA, Johnson RJ. Uric Acid and Hypertension: An Update With Recommendations. Am J Hypertens. 2020 Jul 18;33(7):583-594. PubMed PMID: 32179896
  • Butler-Dawson J, Dally M, Johnson RJ, Johnson EC, Krisher L, Sánchez-Lozada LG, Griffin BR, Brindley S, Newman LS. Association of Copeptin, a Surrogate Marker of Arginine Vasopressin, with Decreased Kidney Function in Sugarcane Workers in Guatemala. Ann Nutr Metab. 2020;76(1):30-36. PubMed PMID: 32172243
  • Dally M, Butler-Dawson J, Cruz A, Krisher L, Johnson RJ, Asensio C, Pilloni WD, Asturias EJ, Newman LS. Longitudinal trends in renal function among first time sugarcane harvesters in Guatemala. PLoS One. 2020;15(3):e0229413. PubMed PMID: 32142520
  • Golembiewska E, Qureshi AR, Dai L, Lindholm B, Heimbürger O, Söderberg M, Brismar TB, Ripsweden J, Barany P, Johnson RJ, Stenvinkel P. Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5. BMC Nephrol. 2020 Feb 7;21(1):43. PubMed PMID: 32033584
  • Kanbay M, Siriopol D, Ozdogan E, Afsar B, Ertuglu LA, Grigore M, Sag AA, Kuwabara M, Lanaspa MA, Ortiz A, Johnson RJ, Covic A. Serum osmolarity as a potential predictor for contrast-induced nephropathy following elective coronary angiography. Int Urol Nephrol. 2020 Mar;52(3):541-547. PubMed PMID: 32008199
  • Wesseling C, Glaser J, Rodríguez-Guzmán J, Weiss I, Lucas R, Peraza S, da Silva AS, Hansson E, Johnson RJ, Hogstedt C, Wegman DH, Jakobsson K. Chronic kidney disease of non-traditional origin in Mesoamerica: a disease primarily driven by occupational heat stress. Rev Panam Salud Publica. 2020;44:e15. PubMed PMID: 31998376
  • 450. Baldwin W, McCrae S, Wymer D, Johnson RJ, Sautin YY. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome Diabetes (in press)
  • Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR. Fructose and hepatic insulin resistance. Crit Rev Clin Lab Sci. 2020 Aug;57(5):308-322. PubMed PMID: 31935149
  • Aslan G, Afsar B, Sag AA, Camkiran V, Erden N, Yilmaz S, Siriopol D, Incir S, You Z, Garcia ML, Covic A, Cherney DZI, Johnson RJ, Kanbay M. The Effect of Urine pH and Urinary Uric Acid Levels on the Development of Contrast Nephropathy. Kidney Blood Press Res. 2020;45(1):131-141. PubMed PMID: 31865342
  • 451. Johnson RJ, Lanaspa MA, Gaucher EA. Uric acid: A Danger Signal from the RNA World that may have a role in the Epidemic of Obesity, Metabolic Syndrome and CardioRenal Disease: Evolutionary Considerations Seminars Nephrol (in press)
  • Joosten LAB, Crisan TO, Bjornstad P, Johnson RJ. Asymptomatic hyperuricaemia: a silent activator of the innate immune system. Nat Rev Rheumatol. 2020 Feb;16(2):75-86. PubMed PMID: 31822862
  • García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Corrigendum to "Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages" [Free Radic. Biol. Med. 141 (2019) 182-191]. Free Radic Biol Med. 2020 May 20;152:865-866. PubMed PMID: 31813623
  • Thornley S, King R, Marshall R, Oakley A, Sundborn G, Harrower J, Reynolds E, Arbuckle M, Johnson RJ. How strong is the relationship between scabies and acute rheumatic fever? An analysis of neighbourhood factors. J Paediatr Child Health. 2020 Apr;56(4):600-606. PubMed PMID: 31774599
  • Andrews P, Johnson RJ. Evolutionary basis for the human diet: consequences for human health. J Intern Med. 2020 Mar;287(3):226-237. PubMed PMID: 31733113
  • Stenvinkel P, Painer J, Johnson RJ, Natterson-Horowitz B. Biomimetics - Nature's roadmap to insights and solutions for burden of lifestyle diseases. J Intern Med. 2020 Mar;287(3):238-251. PubMed PMID: 31639885
  • Johnson RJ, Stenvinkel P, Andrews P, Sánchez-Lozada LG, Nakagawa T, Gaucher E, Andres-Hernando A, Rodriguez-Iturbe B, Jimenez CR, Garcia G, Kang DH, Tolan DR, Lanaspa MA. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med. 2020 Mar;287(3):252-262. PubMed PMID: 31621967
  • Al-Ozairi E, Rivard CJ, Sanchez Lozada LG, Lanaspa MA, Bjornstad P, Al Salem D, Alhubail A, Megahed A, Kuwabara M, Johnson RJ, Asad RA. Fructose tolerance test in obese people with and without type 2 diabetes. J Diabetes. 2020 Mar;12(3):197-204. PubMed PMID: 31472036
  • 452. Johnson RJ, Kanbay M, Sanchez-Lozada LG. Introduction: The Rediscovery of Uric acid in CardioRenal Disease Sem Nephrol (in press)
  • 453. Kanbay M, et al Elevated Admission Serum Uric Acid Predicts Angiographic Impaired Reperfusion and One-Year Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention. Journal Investig Med (in press)
  • 454. Rodríguez-Iturbe B, Franco M, Tapia E, Quiroz Y, and Johnson RJ. Renal inflammation, autoimmunity and salt-sensitive hypertension (submitted) Clin Exp Pharm Physiol (in press)
  • Volek JS, Phinney SD, Krauss RM, Johnson RJ, Saslow LR, Gower B, Yancy WS Jr, King JC, Hecht FM, Teicholz N, Bistrian BR, Hamdy O. Alternative Dietary Patterns for Americans: Low-Carbohydrate Diets. Nutrients. 2021 Sep 22;13(10). PubMed PMID: 34684300
  • Goldberg A, Garcia-Arroyo F, Sasai F, Rodriguez-Iturbe B, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Mini Review: Reappraisal of Uric Acid in Chronic Kidney Disease. Am J Nephrol. 2021 Oct 21;:1-8. [Epub ahead of print] PubMed PMID: 34673651
  • Andres-Hernando A, Cicerchi C, Kuwabara M, Orlicky DJ, Sanchez-Lozada LG, Nakagawa T, Johnson RJ, Lanaspa MA. Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation. Nat Metab. 2021 Sep;3(9):1189-1201. PubMed PMID: 34552272
  • Fini MA, Lanaspa MA, Gaucher EA, Boutwell B, Nakagawa T, Wright RM, Sanchez-Lozada LG, Andrews P, Stenmark KR, Johnson RJ. Brief report: The uricase mutation in humans increases our risk for cancer growth. Cancer Metab. 2021 Sep 15;9(1):32. PubMed PMID: 34526149
  • Butler-Dawson J, Krisher L, Dally M, James KA, Johnson RJ, Jaramillo D, Yoder H, Johnson EC, Pilloni D, Asensio C, Cruz A, Newman LS. Sugarcane Workweek Study: Risk Factors for Daily Changes in Creatinine. Kidney Int Rep. 2021 Sep;6(9):2404-2414. PubMed PMID: 34514201
  • Garcia GE, Truong LD, Johnson RJ. Angiotensin-converting enzyme 2 decreased expression during kidney inflammatory diseases: implications to predisposing to COVID-19 kidney complications. Kidney Int. 2021 Nov;100(5):1138-1140. PubMed PMID: 34474076
  • 455. Garcia GE, Truong LD, Chen JF, Johnson RJ, Feng L. Adenosine A2A Receptor Activation Prevents Progressive Kidney Fibrosis in a Model of Immune-Associated Chronic Inflammation. Kidney Int (in press)
  • Sasai F, Roncal-Jimenez C, Rogers K, Sato Y, Brown JM, Glaser J, Garcia G, Sanchez-Lozada LG, Rodriguez-Iturbe B, Dawson JB, Sorensen C, Hernando AA, Gonzalez-Quiroz M, Lanaspa M, Newman L, Johnson RJ. Climate Change and Nephrology. Nephrol Dial Transplant. 2021 Sep 2. [Epub ahead of print] PubMed PMID: 34473287
  • Garcia GE, Lu YJ, Truong LD, Roncal-Jiménez CA, Miyazaki M, Miyazaki-Anzai S, Cara-Fuentes G, Andres-Hernando A, Lanaspa M, Johnson RJ, Leamon CP. A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats. Cells. 2021 Aug 17;10(8). PubMed PMID: 34440885
  • 461. Roncal Jimenez CA, Lanaspa MA, Rivard CJ, Nakagawa T, Sanchez-Lozada LG, Andres-Hernando A, Tanabe K, Madero M, Sautin YY, Johnson RJ. Sucrose induces Fatty Liver and Type II Diabetes in Rats Independent of Energy Intake. Metabolism (in press)
  • Piani F, Melena I, Severn C, Chung LT, Vinovskis C, Cherney D, Pyle L, Roncal-Jimenez CA, Lanaspa MA, Rewers A, van Raalte DH, Obeid W, Parikh C, Nelson RG, Pavkov ME, Nadeau KJ, Johnson RJ, Bjornstad P. Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study. Pediatr Diabetes. 2021 Nov;22(7):1031-1039. PubMed PMID: 34435718
  • 469. Kanbay M, Yilmaz MI, Sonmez A, Turgut F, SaglamM, Cakir E, Yenicesu M, Covic A, Jalal D, JohnsonRJ. Serum Uric Acid Level and Endothelial Dysfunction in Patients with Nondiabetic Chronic Kidney Disease Am J Nephrol (in press)
  • Takeuchi K, Ariyoshi Y, Shimizu A, Okumura Y, Cara-Fuentes G, Garcia GE, Pomposelli T, Watanabe H, Boyd L, Ekanayake-Alper DK, Amarnath D, Sykes M, Sachs DH, Johnson RJ, Yamada K. Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig-to-baboon xenotransplantation. Xenotransplantation. 2021 Aug 21. [Epub ahead of print] PubMed PMID: 34418164
  • Shiels PG, Painer J, Natterson-Horowitz B, Johnson RJ, Miranda JJ, Stenvinkel P. Manipulating the exposome to enable better ageing. Biochem J. 2021 Jul 30;478(14):2889-2898. PubMed PMID: 34319404
  • Nakagawa T, Sanchez-Lozada LG, Andres-Hernando A, Kojima H, Kasahara M, Rodriguez-Iturbe B, Bjornstad P, Lanaspa MA, Johnson RJ. Endogenous Fructose Metabolism Could Explain the Warburg Effect and the Protection of SGLT2 Inhibitors in Chronic Kidney Disease. Front Immunol. 2021;12:694457. PubMed PMID: 34220855
  • Piani F, Reinicke T, Borghi C, Tommerdahl KL, Cara-Fuentes G, Johnson RJ, Bjornstad P. Acute Kidney Injury in Pediatric Diabetic Kidney Disease. Front Pediatr. 2021;9:668033. PubMed PMID: 34211943
  • 455. Garcia GE, Truong LD, Chen JF, Johnson RJ, Feng L. Adenosine A2A Receptor Activation Prevents Progressive Kidney Fibrosis in a Model of Immune-Associated Chronic Inflammation. Kidney Int (in press)
  • Kanbay M, Guler B, Ertuglu LA, Dagel T, Afsar B, Incir S, Baygul A, Covic A, Andres-Hernando A, Sánchez-Lozada LG, Lanaspa MA, Johnson RJ. The Speed of Ingestion of a Sugary Beverage Has an Effect on the Acute Metabolic Response to Fructose. Nutrients. 2021 Jun 2;13(6). PubMed PMID: 34199607
  • Carn D, Lanaspa MA, Benner SA, Andrews P, Dudley R, Andres-Hernando A, Tolan DR, Johnson RJ. The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis. Alcohol Clin Exp Res. 2021 Aug;45(8):1519-1526. PubMed PMID: 34120350
  • 458. PanzerU, Jan-Eric Turner J-E, Steinmetz OM, Kurts C, Johnson RJ, Stahl RAK. ISN Forefront Symposium 2010 in Sylt, Germany: ‘Induction and Resolution of Renal Inflammation’ Kidney Int (in press)
  • Johnson RJ, Wilson WL, Bland ST, Lanaspa MA. Fructose and Uric Acid as Drivers of a Hyperactive Foraging Response: A Clue to Behavioral Disorders Associated with Impulsivity or Mania?. Evol Hum Behav. 2021 May;42(3):194-203. PubMed PMID: 33994772
  • Demiray A, Afsar B, Covic A, Kuwabara M, Ferro CJ, Lanaspa MA, Johnson RJ, Kanbay M. The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review. Angiology. 2021 Apr 27;:33197211012546. [Epub ahead of print] PubMed PMID: 33902350
  • Johnson RJ, Lanaspa MA, Fox JW. Response to "Female Figurines, Climate Sensationalism, and Archaeological Shortcomings". Obesity (Silver Spring). 2021 May;29(5):782. PubMed PMID: 33733576
  • Piani F, Sasai F, Bjornstad P, Borghi C, Yoshimura A, Sanchez-Lozada LG, Roncal-Jimenez C, Garcia GE, Hernando AA, Fuentes GC, Rodriguez-Iturbe B, Lanaspa MA, Johnson RJ. Hyperuricemia and chronic kidney disease: to treat or not to treat. J Bras Nefrol. 2021 Mar 5. [Epub ahead of print] PubMed PMID: 33704350
  • Ejaz AA, Nakagawa T, Kanbay M, Kuwabara M, Kumar A, Garcia Arroyo FE, Roncal-Jimenez C, Sasai F, Kang DH, Jensen T, Hernando AA, Rodriguez-Iturbe B, Garcia G, Tolan DR, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Hyperuricemia in Kidney Disease: A Major Risk Factor for Cardiovascular Events, Vascular Calcification, and Renal Damage. Semin Nephrol. 2020 Nov;40(6):574-585. PubMed PMID: 33678312
  • García-Arroyo FE, Gonzaga-Sánchez G, Tapia E, Muñoz-Jiménez I, Manterola-Romero L, Osorio-Alonso H, Arellano-Buendía AS, Pedraza-Chaverri J, Roncal-Jiménez CA, Lanaspa MA, Johnson RJ, Sánchez-Lozada LG. Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet. Int J Mol Sci. 2021 Feb 28;22(5). PubMed PMID: 33670975
  • Butler-Dawson J, James KA, Krisher L, Jaramillo D, Dally M, Neumann N, Pilloni D, Cruz A, Asensio C, Johnson RJ, Adgate J, Newman LS. Environmental metal exposures and kidney function of Guatemalan sugarcane workers. J Expo Sci Environ Epidemiol. 2021 Feb 18. [Epub ahead of print] PubMed PMID: 33603096
  • Fox J, Macaluso F, Moore C, Mesenbring E, Johnson RJ, Hamman RF, James KA. Urine tungsten and chronic kidney disease in rural Colorado. Environ Res. 2021 Apr;195:110710. PubMed PMID: 33460634
  • Piani F, Melena I, Tommerdahl KL, Nokoff N, Nelson RG, Pavkov ME, van Raalte DH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P. Sex-related differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications. J Diabetes Complications. 2021 Apr;35(4):107841. PubMed PMID: 33423908
  • Piani F, Johnson RJ. Does gouty nephropathy exist, and is it more common than we think?. Kidney Int. 2021 Jan;99(1):31-33. PubMed PMID: 33390238
  • 459. Ishimoto T, Shimada M, Araya CE, Huskey J, Garin EH, Johnson RJ/ Minimal Change Disease: A CD80 Podocytopathy? Sem Nephrol (in press)
  • 460. Kanbay M, Ikizek M, Solak Y, Selcoki Y, Uysal S, Armutcu F, Eryonucu B, Covic A, Johnson RJ.Serum Uric and Pentraxine-3 Levels are Independently Associated with Extent of Coronary Artery Disease in a Patient Cohort with Mild Chronic Kidney Disease Am J Nephrol (in press)
  • 454. Johnson RJ, Lanaspa MA, Gaucher EA. Uric acid: A Danger Signal from the RNA World that may have a role in the Epidemic of Obesity, Metabolic Syndrome and CardioRenal Disease: Evolutionary Considerations Semin Nephrol 2011 Sep; 31:394-399
  • 455. Lanaspa MA, Sautin YY, Ejaz AA, Madero M, Le M, Manitius J, Sanchez-Lozada LG, Nakagawa T, Johnson RJ. Uric acid and metabolic syndrome: What is the relationship? Current Rheumatol Reviews 2011; 7:162-169
  • 456. Johnson RJ, Kanbay M, Sanchez-Lozada LG. Introduction: The Rediscovery of Uric acid in CardioRenal Disease: Introduction Sem Nephrol 2011; Sep 31:391-3
  • Floege J, Johnson RJ. Hyperuricemia and progression of chronic kidney disease: to treat or not to treat?. Kidney Int. 2021 Jan;99(1):14-16. PubMed PMID: 33390225
  • Maier S, Wieland A, Cree-Green M, Nadeau K, Sullivan S, Lanaspa MA, Johnson RJ, Jensen T. Lean NAFLD: an underrecognized and challenging disorder in medicine. Rev Endocr Metab Disord. 2021 Jun;22(2):351-366. PubMed PMID: 33389543
  • García-Arroyo FE, Tapia E, Muñoz-Jiménez I, Gonzaga-Sánchez G, Arellano-Buendía AS, Osorio-Alonso H, Manterola-Romero L, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage. Oxid Med Cell Longev. 2020;2020:8850266. PubMed PMID: 33354281
  • Andres-Hernando A, Jensen TJ, Kuwabara M, Orlicky DJ, Cicerchi C, Li N, Roncal-Jimenez CA, Garcia GE, Ishimoto T, Maclean PS, Bjornstad P, Sanchez-Lozada LG, Kanbay M, Nakagawa T, Johnson RJ, Lanaspa MA. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. JCI Insight. 2021 Jan 11;6(1). PubMed PMID: 33320834
  • Johnson RJ, Lanaspa MA, Fox JW. Upper Paleolithic Figurines Showing Women with Obesity may Represent Survival Symbols of Climatic Change. Obesity (Silver Spring). 2021 Jan;29(1):11-15. PubMed PMID: 33258218
  • Ebert T, Painer J, Bergman P, Qureshi AR, Giroud S, Stalder G, Kublickiene K, Göritz F, Vetter S, Bieber C, Fröbert O, Arnemo JM, Zedrosser A, Redtenbacher I, Shiels PG, Johnson RJ, Stenvinkel P. Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears. Sci Rep. 2020 Nov 23;10(1):20323. PubMed PMID: 33230252
  • Li JW, Yin D, Wang Z, Brigham MD, LaMoreaux BD, Kent JD, Francis-Sedlak M, Johnson RJ, Hadker N, Francis KM, Sanchez HA, Miyasato G. New-Onset Gout as an Independent Risk Factor for Returning to Dialysis After Kidney Transplantation. Transplant Direct. 2020 Dec;6(12):e634. PubMed PMID: 33225059
  • Kang DH, Sanchez-Lozada LG, Johnson RJ. Allopurinol and Chronic Kidney Disease. N Engl J Med. 2020 Oct 22;383(17):1687-1688. PubMed PMID: 33085871
  • Johnson RJ, Gomez-Pinilla F, Nagel M, Nakagawa T, Rodriguez-Iturbe B, Sanchez-Lozada LG, Tolan DR, Lanaspa MA. Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer's Disease. Front Aging Neurosci. 2020;12:560865. PubMed PMID: 33024433
  • Khanna P, Johnson RJ, Marder B, LaMoreaux B, Kumar A. Systemic Urate Deposition: An Unrecognized Complication of Gout?. J Clin Med. 2020 Oct 3;9(10). PubMed PMID: 33023045
  • 457. Basar N, Sen N, Ozcan F, Erden G, Kanat S, Sokmen E, Isleyen A, Yuzgecer H, Ozlu MF, Yildirimkaya M, Maden O, Covic A, Johnson RJ, Kanbay M. Elevated Serum Uric Acid Predicts Angiographic Impaired Reperfusion and 1-Year Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention. J Investig Med. 2011 Aug;59(6):931-937
  • Dally M, Butler-Dawson J, Johnson RJ, Krisher L, Jaramillo D, Newman KL, Newman LS. Creatinine Fluctuations Forecast Cross-Harvest Kidney Function Decline Among Sugarcane Workers in Guatemala. Kidney Int Rep. 2020 Sep;5(9):1558-1566. PubMed PMID: 32954081
  • 458. Rodríguez-Iturbe B, Franco M, Tapia E, Quiroz Y, and Johnson RJ. Renal inflammation, autoimmunity and salt-sensitive hypertension. Clin Exp Pharm Physiol 2012; 39:96-103
  • 459. Garcia GE, Truong LD, Chen JF, Johnson RJ, Feng L. Adenosine A2A Receptor Activation Prevents Progressive Kidney Fibrosis in a Model of Immune-Associated Chronic Inflammation. Kidney Int 2011 Aug;80(4):378-88
  • Schaeffer JW, Adgate JL, Reynolds SJ, Butler-Dawson J, Krisher L, Dally M, Johnson RJ, James KA, Jaramillo D, Newman LS. A Pilot Study to Assess Inhalation Exposures among Sugarcane Workers in Guatemala: Implications for Chronic Kidney Disease of Unknown Origin. Int J Environ Res Public Health. 2020 Aug 7;17(16). PubMed PMID: 32784623
  • Borghi C, Agabiti-Rosei E, Johnson RJ, Kielstein JT, Lurbe E, Mancia G, Redon J, Stack AG, Tsioufis KP. Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease. Eur J Intern Med. 2020 Oct;80:1-11. PubMed PMID: 32739239
  • Vinovskis C, Li LP, Prasad P, Tommerdahl K, Pyle L, Nelson RG, Pavkov ME, van Raalte D, Rewers M, Pragnell M, Mahmud FH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P. Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes. Diabetes. 2020 Dec;69(12):2700-2708. PubMed PMID: 32737116
  • Stenvinkel P, Shiels PG, Painer J, Miranda JJ, Natterson-Horowitz B, Johnson RJ. A planetary health perspective for kidney disease. Kidney Int. 2020 Aug;98(2):261-265. PubMed PMID: 32709283
  • Nakagawa T, Lanaspa MA, Millan IS, Fini M, Rivard CJ, Sanchez-Lozada LG, Andres-Hernando A, Tolan DR, Johnson RJ. Fructose contributes to the Warburg effect for cancer growth. Cancer Metab. 2020;8:16. PubMed PMID: 32670573
  • Stenvinkel P, Painer J, Shiels PG, Bansal A, Fereidouni S, Natterson-Horowitz B, Johnson RJ, Miranda JJ. SARS-COV-2 and biomimetics: What saves the planet will save our health. J Intern Med. 2021 Feb;289(2):244-246. PubMed PMID: 32583447
  • Andres-Hernando A, Kuwabara M, Orlicky DJ, Vandenbeuch A, Cicerchi C, Kinnamon SC, Finger TE, Johnson RJ, Lanaspa MA. Sugar causes obesity and metabolic syndrome in mice independently of sweet taste. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E276-E290. PubMed PMID: 32574112
  • Andres-Hernando A, Orlicky DJ, Kuwabara M, Ishimoto T, Nakagawa T, Johnson RJ, Lanaspa MA. Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction. Cell Metab. 2020 Jul 7;32(1):117-127.e3. PubMed PMID: 32502381
  • Hansson E, Glaser J, Jakobsson K, Weiss I, Wesseling C, Lucas RAI, Wei JLK, Ekström U, Wijkström J, Bodin T, Johnson RJ, Wegman DH. Pathophysiological Mechanisms by which Heat Stress Potentially Induces Kidney Inflammation and Chronic Kidney Disease in Sugarcane Workers. Nutrients. 2020 Jun 2;12(6). PubMed PMID: 32498242
  • Aguilar-Ramirez D, Raña-Custodio A, Villa A, Rubilar X, Olvera N, Escobar A, Johnson RJ, Sanchez-Lozada L, Obrador GT, Madero M. Decreased kidney function and agricultural work: a cross-sectional study in middle-aged adults from Tierra Blanca, Mexico. Nephrol Dial Transplant. 2021 May 27;36(6):1030-1038. PubMed PMID: 32443156
  • Kuwabara M, Kanbay M, Niwa K, Ae R, Andres-Hernando A, Roncal-Jimenez CA, Garcia G, Sánchez-Lozada LG, Rodriguez-Iturbe B, Hisatome I, Lanaspa MA, Johnson RJ. Hyperosmolarity and Increased Serum Sodium Concentration Are Risks for Developing Hypertension Regardless of Salt Intake: A Five-Year Cohort Study in Japan. Nutrients. 2020 May 14;12(5). PubMed PMID: 32423124
  • 460. Roncal Jimenez CA, Lanaspa MA, Rivard CJ, Nakagawa T, Sanchez-Lozada LG, Andres-Hernando A, Tanabe K, Madero M, Sautin YY, Johnson RJ. Sucrose induces Fatty Liver and Type II Diabetes in Rats Independent of Energy Intake. Metabolism 2011 Sep;60(9):1259-70
  • 461. Ishimoto T, Shimada M, Araya CE, Huskey J, Garin EH, Johnson RJ/ Minimal Change Disease: A CD80 Podocytopathy? Sem Nephrol 2011 Jul;31(4):320-5.
  • Cara-Fuentes G, Venkatareddy M, Verma R, Segarra A, Cleuren AC, Martínez-Ramos A, Johnson RJ, Garg P. Glomerular endothelial cells and podocytes can express CD80 in patients with minimal change disease during relapse. Pediatr Nephrol. 2020 Oct;35(10):1887-1896. PubMed PMID: 32399663
  • 462. Arestegui AH, Fuquay R, Sirota J, Swenson ER, Schoene RB, Jefferson JA, Chen W, Yu X, Kelly JP , Johnson RJ, Escudero E. High Altitude Renal Syndrome. J Am Soc Nephrol 2011 Nov;22(11):1963-8
  • 463. Madero M, Arriaga JC, Jalal D, Rivard C, McFann K, Pérez-Méndez O, Vázquez A, Ruiz A, Lanaspa MA, Jimenez CR, Johnson RJ, Lozada LG. The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial. Metabolism. 2011 Nov;60(11):1551-9
  • Phadke G, Kaushal A, Tolan DR, Hahn K, Jensen T, Bjornstad P, Roncal-Jimenez C, Hernando AA, Lanaspa MA, Alexander MP, Kukla A, Johnson RJ. Osmotic Nephrosis and Acute Kidney Injury Associated With SGLT2 Inhibitor Use: A Case Report. Am J Kidney Dis. 2020 Jul;76(1):144-147. PubMed PMID: 32387022
  • Sato Y, Feig DI, Stack AG, Kang DH, Lanaspa MA, Ejaz AA, Sánchez-Lozada LG, Kuwabara M, Borghi C, Johnson RJ. Reply to 'The case for evidence-based medicine for the association between hyperuricaemia and CKD'. Nat Rev Nephrol. 2020 Jul;16(7):422-423. PubMed PMID: 32313213
  • Li JW, Suh M, Brigham MD, Kent JD, LaMoreaux B, Johnson RJ, Mandell BF, Hadker N, Sanchez H, Francis K, Miyasato G. A Retrospective Cohort Study of the Effect of Gout on Mortality Among Patients with a History of Kidney Transplantation. Ann Transplant. 2020 Apr 14;25:e920553. PubMed PMID: 32284525
  • Nakagawa T, Johnson RJ, Andres-Hernando A, Roncal-Jimenez C, Sanchez-Lozada LG, Tolan DR, Lanaspa MA. Fructose Production and Metabolism in the Kidney. J Am Soc Nephrol. 2020 May;31(5):898-906. PubMed PMID: 32253274
  • Kuwabara M, Hisatome I, Niwa K, Bjornstad P, Roncal-Jimenez CA, Andres-Hernando A, Kanbay M, Johnson RJ, Lanaspa MA. The Optimal Range of Serum Uric Acid for Cardiometabolic Diseases: A 5-Year Japanese Cohort Study. J Clin Med. 2020 Mar 30;9(4). PubMed PMID: 32235468
  • 464. Kanbay M, Huddam B, Azak A, Solak Y, Kadioglu GK, Kirbas I, Duranay M, Covic A, Johnson RJ. Allopurinol improves endothelial dysfunction, and eGFR in asymptomatic hyperuricemic subjects with normal renal function: A prospective randomized study. CJASN 2011 Aug;6(8):1887-94
  • 465. Afsar B, Elsurer R, Covic A, Johnson RJ, Kanbay M Relationship between Uric Acid and Subtle Cognitive Dysfunction in Chronic Kidney Disease. Am J Nephrol. 2011 Jun 10;34(1):49-54
  • 466. Kanbay M, Sanchez-Lozada LG, Madero M, Johnson RJ. Reply to Dr White. Nephrol Dial Transpl 2011 Oct; 26:3420-3421
  • 467. Johnson RJ, Avena N, Ishimoto T, Johnson DR, Zahniser N, Gold M. Attention Deficit Hyperactivity Disorder: Time to Reappraise the Role of Sugar? Postgraduate Medicine 2011 Sep;123(5):39-49.
  • Kuwabara M, Borghi C, Johnson RJ. Febuxostat and atrial fibrillation. Eur Heart J. 2020 Aug 7;41(30):2916-2917. PubMed PMID: 32227166
  • 468. Johnson RJ, Kanbay M, Kang DH, Sanchez-Lozada LG, Feig D. Uric acid: A Clinically Useful Marker to Distinguish Preeclampsia from Gestational Hypertension. Hypertension 2011 Oct;58(4):548-9
  • Brigham MD, Milgroom A, Lenco MO, Wang Z, Kent JD, LaMoreaux B, Johnson RJ, Mandell BF, Hadker N, Sanchez H, Francis K, Radeck LP, Miyasato G, Li JW. Immunosuppressant Use and Gout in the Prevalent Solid Organ Transplantation Population. Prog Transplant. 2020 Jun;30(2):103-110. PubMed PMID: 32208882
  • Sanchez-Lozada LG, Rodriguez-Iturbe B, Kelley EE, Nakagawa T, Madero M, Feig DI, Borghi C, Piani F, Cara-Fuentes G, Bjornstad P, Lanaspa MA, Johnson RJ. Uric Acid and Hypertension: An Update With Recommendations. Am J Hypertens. 2020 Jul 18;33(7):583-594. PubMed PMID: 32179896
  • Butler-Dawson J, Dally M, Johnson RJ, Johnson EC, Krisher L, Sánchez-Lozada LG, Griffin BR, Brindley S, Newman LS. Association of Copeptin, a Surrogate Marker of Arginine Vasopressin, with Decreased Kidney Function in Sugarcane Workers in Guatemala. Ann Nutr Metab. 2020;76(1):30-36. PubMed PMID: 32172243
  • Dally M, Butler-Dawson J, Cruz A, Krisher L, Johnson RJ, Asensio C, Pilloni WD, Asturias EJ, Newman LS. Longitudinal trends in renal function among first time sugarcane harvesters in Guatemala. PLoS One. 2020;15(3):e0229413. PubMed PMID: 32142520
  • Golembiewska E, Qureshi AR, Dai L, Lindholm B, Heimbürger O, Söderberg M, Brismar TB, Ripsweden J, Barany P, Johnson RJ, Stenvinkel P. Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5. BMC Nephrol. 2020 Feb 7;21(1):43. PubMed PMID: 32033584
  • Kanbay M, Siriopol D, Ozdogan E, Afsar B, Ertuglu LA, Grigore M, Sag AA, Kuwabara M, Lanaspa MA, Ortiz A, Johnson RJ, Covic A. Serum osmolarity as a potential predictor for contrast-induced nephropathy following elective coronary angiography. Int Urol Nephrol. 2020 Mar;52(3):541-547. PubMed PMID: 32008199
  • Wesseling C, Glaser J, Rodríguez-Guzmán J, Weiss I, Lucas R, Peraza S, da Silva AS, Hansson E, Johnson RJ, Hogstedt C, Wegman DH, Jakobsson K. Chronic kidney disease of non-traditional origin in Mesoamerica: a disease primarily driven by occupational heat stress. Rev Panam Salud Publica. 2020;44:e15. PubMed PMID: 31998376
  • Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR. Fructose and hepatic insulin resistance. Crit Rev Clin Lab Sci. 2020 Aug;57(5):308-322. PubMed PMID: 31935149
  • 469. Shi Y, Chen W, Jalal D, Li Z, Chen W, Mao H, Yang Q, Johnson RJ, Yu X. Clinical outcome of hyperuricemia in IgA nephropathy clinical outcome: A retrospective cohort study and randomized controlled trial Kidney Blood Pressure Res 2011; Nov; 35:153-160
  • Aslan G, Afsar B, Sag AA, Camkiran V, Erden N, Yilmaz S, Siriopol D, Incir S, You Z, Garcia ML, Covic A, Cherney DZI, Johnson RJ, Kanbay M. The Effect of Urine pH and Urinary Uric Acid Levels on the Development of Contrast Nephropathy. Kidney Blood Press Res. 2020;45(1):131-141. PubMed PMID: 31865342
  • 470. Sulikowska B, Johnson RJ, Odrowaz-Sypniewska G, Manitius J. Uric acid, Renal Vasoconstriction and Erythropoietin Relationship in IgA Nephropathy Revealed by Dopamine-induced Glomerular Filtration Response. Kidney Blood Pressure Res 2011; 35:161-166
  • 471. Mazali FC, Johnson RJ, Mazzali M. Use of Uric acid lowering agents limits experimental cyclosporine nephropathy. Nephron Exp Nephrol 2011; 120:e12-e19 (in press)
  • 472. Lapsia V, Johnson RJ, Dass B, Shimada M, Kambhampati G, Ejaz NI, Arif AA, Ejaz AA. Elevated Uric Acid Increases the Risk for Acute Kidney Injury in Cardiovascular Surgery. Am J Med (in press)
  • 473. Kretowicz M, Johnson RJ, Ishimoto T, Nakagawa T, Manitius J. The impact of fructose on renal function and blood pressure. Int J Nephrol 2011 (in press)
  • 474. Brymora A, Flisinski M, Johnson RJ, Goszka G, Stefanska A, Manitius J. Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease. Nephrol Dial Transpl (in press
  • 475. Shimada M, Ishimoto T, Lee PY, Lanaspa MA, Rivard C, Roncal-Jimenez CA, Wymer D, Mathieson PW, Saleem MA, Garin EH, Johnson RJ. Toll-like receptor 3 ligands induce CD80 expression in Human Podocytes via an NF?B Dependent Pathway. Nephrol Dial Transpl (in press)
  • 476. Le MT, Frye RF, Rivard CJ, Cheng J, McFann KK, Segal MS, Johnson RJ, Johnson JA. Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism. 2011 (in press)
  • Joosten LAB, Crisan TO, Bjornstad P, Johnson RJ. Asymptomatic hyperuricaemia: a silent activator of the innate immune system. Nat Rev Rheumatol. 2020 Feb;16(2):75-86. PubMed PMID: 31822862
  • García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Corrigendum to "Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages" [Free Radic. Biol. Med. 141 (2019) 182-191]. Free Radic Biol Med. 2020 May 20;152:865-866. PubMed PMID: 31813623
  • Thornley S, King R, Marshall R, Oakley A, Sundborn G, Harrower J, Reynolds E, Arbuckle M, Johnson RJ. How strong is the relationship between scabies and acute rheumatic fever? An analysis of neighbourhood factors. J Paediatr Child Health. 2020 Apr;56(4):600-606. PubMed PMID: 31774599
  • Andrews P, Johnson RJ. Evolutionary basis for the human diet: consequences for human health. J Intern Med. 2020 Mar;287(3):226-237. PubMed PMID: 31733113
  • Stenvinkel P, Painer J, Johnson RJ, Natterson-Horowitz B. Biomimetics - Nature's roadmap to insights and solutions for burden of lifestyle diseases. J Intern Med. 2020 Mar;287(3):238-251. PubMed PMID: 31639885
  • Johnson RJ, Stenvinkel P, Andrews P, Sánchez-Lozada LG, Nakagawa T, Gaucher E, Andres-Hernando A, Rodriguez-Iturbe B, Jimenez CR, Garcia G, Kang DH, Tolan DR, Lanaspa MA. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med. 2020 Mar;287(3):252-262. PubMed PMID: 31621967
  • Al-Ozairi E, Rivard CJ, Sanchez Lozada LG, Lanaspa MA, Bjornstad P, Al Salem D, Alhubail A, Megahed A, Kuwabara M, Johnson RJ, Asad RA. Fructose tolerance test in obese people with and without type 2 diabetes. J Diabetes. 2020 Mar;12(3):197-204. PubMed PMID: 31472036
  • 477. Ishimoto T, Lanaspa MA, Le MT, Garcia G, Diggle CP, MacLean PS, Jackman MR, Asipu A, Roncal C, Kosugi T, Rivard C, Maruyama S, Rodriguez-Iturbe B, Sanchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ. Opposing effects of fructokinase C and A isoforms on Fructose-induced Metabolic Syndrome. Proc Natl Acad Sci USA (in press)
  • 478. Tanabe K, KitagawaW, Garcia ML, RivardC, Miyazaki M, Schreiner G, Johnson RJ, Nakagawa T. Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS deficient mice. Am J Physiol (in press)
  • 53. Nakagawa T, Johnson RJ. Endothelial nitric oxide synthase. Contrib Nephrol. 2011;170:93-101. Kar N Lai (and Sydney Tang (editors)
  • 54. Kang DH, Kanbay M, Johnson RJ. Hyperuricemia, Gout and the Kidney. In Diseases of the Kidney, Tenth Edition. Eds RW , Ron Falk, Bruce Molitoris, Eric Neilson. Little Brown Co., Boston, 2011.
  • The Fat Switch, by Richard J Johnson, mercola.com publisher, Chicago, 300 pp
  • 491. Shafiu M, Johnson RJ, Lanagaee T, Johnson J. Uric acid transporter gene SLC22A12 polymorphisms associated with obesity, low HDL and metabolic syndrome in Caucasians with Primary Hypertension. Kidney Blood Pressure Research (in press)
  • Nakagawa T, Ana Andres-Hernando, Kosugi T, Sanchez-Lozada LG, Stenvinkel P, Kublickiene K, Ananth Karumanchi S, Kang DH, Kojima H, Rodriguez-Iturbe B, Tolan DR, Lanaspa MA, Johnson RJ. Fructose might be a clue to the origin of preeclampsia insights from nature and evolution. Hypertens Res. 2022 Dec 20. [Epub ahead of print] PubMed PMID: 36539464
  • 479. Abdelmalak MF, Lazo M, Horska H, Bonnekamp S, Lipkin EW, Balasubramanyam A, Bantle JP,Johnson RJ, Diehl AM, Clark JM. Higher Dietary Fructose Is Associated with Impaired Hepatic ATP Homeostasis in Obese individuals with type 2 diabetes Hepatology (in press)
  • Stenvinkel P, Shiels PG, Johnson RJ. Lessons from evolution by natural selection: An unprecedented opportunity to use biomimetics to improve planetary health. J Environ Manage. 2022 Dec 9;328:116981. [Epub ahead of print] PubMed PMID: 36508982
  • Young SE, Khoshnaw LJ, Johnson RJ. Climate and the Nephrologist: The Intersection of Climate Change, Kidney Disease, and Clinical Care. Clin J Am Soc Nephrol. 2022 Nov 1. [Epub ahead of print] PubMed PMID: 36319069
  • Schostak T, San Millan I, Jani A, Johnson RJ. Thiamine deficiency: a commonly unrecognised but easily treatable condition. Postgrad Med J. 2022 Sep 9. [Epub ahead of print] PubMed PMID: 36190946
  • Johnson RJ. Intestinal Hyperuricemia as a Driving Mechanism for CKD. Am J Kidney Dis. 2022 Sep 24. [Epub ahead of print] PubMed PMID: 36167757
  • Johnson RJ, Sánchez-Lozada LG, Nakagawa T, Rodriguez-Iturbe B, Tolan D, Gaucher EA, Andrews P, Lanaspa MA. Do thrifty genes exist? Revisiting uricase. Obesity (Silver Spring). 2022 Oct;30(10):1917-1926. PubMed PMID: 36150210
  • Majumder N, Deepak V, Hadique S, Aesoph D, Velayutham M, Ye Q, Mazumder MHH, Lewis SE, Kodali V, Roohollahi A, Guo NL, Hu G, Khramtsov VV, Johnson RJ, Wen S, Kelley EE, Hussain S. Redox imbalance in COVID-19 pathophysiology. Redox Biol. 2022 Oct;56:102465. PubMed PMID: 36116160
  • Cara-Fuentes G, Andres-Hernando A, Bauer C, Banks M, Garcia GE, Cicerchi C, Kuwabara M, Shimada M, Johnson RJ, Lanaspa MA. Pulmonary surfactants and the respiratory-renal connection in steroid-sensitive nephrotic syndrome of childhood. iScience. 2022 Aug 19;25(8):104694. PubMed PMID: 35847557
  • Sasai F, Rogers KL, Orlicky DJ, Stem A, Schaeffer J, Garcia G, Fox J, Ray MS, Butler-Dawson J, Gonzalez-Quiroz M, Leiva R, Taduri G, Anutrakululchai S, Venugopal V, Madero M, Glaser J, Wijkstrom J, Wernerson A, Brown JM, Johnson RJ, Roncal-Jimenez CA. Inhaled silica nanoparticles cause chronic kidney disease in rats. Am J Physiol Renal Physiol. 2022 Jul 1;323(1):F48-F58. PubMed PMID: 35635324
  • Johnson RJ, García-Arroyo FE, Gonzaga-Sánchez G, Vélez-Orozco KA, Álvarez-Álvarez YQ, Aparicio-Trejo OE, Tapia E, Osorio-Alonso H, Andrés-Hernando A, Nakagawa T, Kuwabara M, Kanbay M, Lanaspa MA, Sánchez-Lozada LG. Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases. Nutrients. 2022 May 15;14(10). PubMed PMID: 35631211
  • Melena I, Piani F, Tommerdahl KL, Severn C, Chung LT, MacDonald A, Vinovskis C, Cherney D, Pyle L, Roncal-Jimenez CA, Lanaspa MA, Rewers A, van Raalte DH, Cara-Fuentes G, Parikh CR, Nelson RG, Pavkov ME, Nadeau KJ, Johnson RJ, Bjornstad P. Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: Results from the diabetic kidney alarm (DKA) study. J Diabetes Complications. 2022 Jun;36(6):108203. PubMed PMID: 35523653
  • Bauer C, Piani F, Banks M, Ordoñez FA, de Lucas-Collantes C, Oshima K, Schmidt EP, Zakharevich I, Segarra A, Martinez C, Roncal-Jimenez C, Satchell SC, Bjornstad P, Lucia MS, Blaine J, Thurman JM, Johnson RJ, Cara-Fuentes G. Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation. Kidney Int Rep. 2022 Apr;7(4):797-809. PubMed PMID: 35497798
  • Rodriguez-Iturbe B, Johnson RJ, Lanaspa MA, Nakagawa T, Garcia-Arroyo FE, Sánchez-Lozada LG. Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis. Am J Physiol Regul Integr Comp Physiol. 2022 May 1;322(5):R347-R359. PubMed PMID: 35271385
  • Johnson RJ, Lanaspa MA, Rodriguez-Iturbe B. Insights into Salt Handling and Blood Pressure. N Engl J Med. 2022 Feb 17;386(7):e18. PubMed PMID: 35172069
  • Chauhan K, Pattharanitima P, Piani F, Johnson RJ, Uribarri J, Chan L, Coca SG. Prevalence and Outcomes Associated with Hyperuricemia in Hospitalized Patients with COVID-19. Am J Nephrol. 2022;53(1):78-86. PubMed PMID: 34883482
  • Watters A, Johnson RJ, Bauschka M, Oakes J, Kelley M, Mehler PS. Uric acid levels in adult patients with severe eating disorders. Int J Eat Disord. 2022 Jan;55(1):141-144. PubMed PMID: 34850969
  • Demiray A, Afsar B, Covic A, Kuwabara M, Ferro CJ, Lanaspa MA, Johnson RJ, Kanbay M. The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review. Angiology. 2022 Jan;73(1):9-17. PubMed PMID: 33902350
  • 482. Madero M, Sanchez-Lozada LG, Johnson RJ. Fructose likely does have a role in hypertension. Hypertension 2012 in press (letter to editor)
  • Butler-Dawson J, James KA, Krisher L, Jaramillo D, Dally M, Neumann N, Pilloni D, Cruz A, Asensio C, Johnson RJ, Adgate J, Newman LS. Environmental metal exposures and kidney function of Guatemalan sugarcane workers. J Expo Sci Environ Epidemiol. 2022 May;32(3):461-471. PubMed PMID: 33603096
  • 481. Ejaz AA, Dass B, Kambhampati G, Ejaz NI, Maroz N, Dhatt GS, Arif AA, Faldu C, Lanaspan MA, Shah G, Johnson RJ. Lowering serum uric acid to prevent acute kidney injury. Medical Hypothesis 2012 (in press)
  • 465. Tanabe K, KitagawaW, Garcia ML, RivardC, Miyazaki M, Schreiner G, Johnson RJ, Nakagawa T. Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS deficient mice. Am J Physiol Renal Physiol. 2012 May;302(9):F1151-60
  • Bjornstad P, Choi YJ, Platnick C, Gross S, Narongkiatikhun P, Melena I, Remmers L, Baca M, Schutte G, Dobbs T, Vigers T, Pyle L, Driscoll L, Tommerdahl K, Kendrick J, Looker HC, Dart A, Cherney D, van Raalte DH, Srivastava A, Li L, Prasad P, Saulnier P, Nelson RG, Johnson RJ, Nadeau KJ. Insulin Secretion, Sensitivity, and Kidney Function in Young Individuals With Type 2 Diabetes. Diabetes Care. 2023 Dec 28. [Epub ahead of print] PubMed PMID: 38153805
  • Rodríguez-Iturbe B, Johnson RJ, Sánchez-Lozada LG. Relationship between hyperuricemia, HSP70 and NLRP3 inflammasome in arterial hypertension. Arch Cardiol Mex. 2023;93(4):458-463. PubMed PMID: 37972372
  • Andres-Hernando A, Orlicky DJ, Kuwabara M, Cicerchi C, Pedler M, Petrash MJ, Johnson RJ, Tolan DR, Lanaspa MA. Endogenous Fructose Production and Metabolism Drive Metabolic Dysregulation and Liver Disease in Mice with Hereditary Fructose Intolerance. Nutrients. 2023 Oct 16;15(20). PubMed PMID: 37892451
  • Rogers KL, Roncal-Jimenez CA, Leiva R, Stem A, Wijkstrom J, Serpas L, González-Quiroz MA, Sasai F, Wernerson A, Schaeffer J, Fox J, Ray M, Bansal A, Urra M, Butler-Dawson J, Lucia S, Newman LS, Glaser J, Johnson RJ, Brown JM. Silica Nanoparticles and Mesoamerican Nephropathy: A Case Series. Am J Kidney Dis. 2023 Oct 19. [Epub ahead of print] PubMed PMID: 37877930
  • 466. Shafiu M, Johnson RJ, Turner ST, Langaee T, Gong Y, Chapman AB, Gums JG, Johnson JA. Uric acid transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with Hypertension. Kidney Blood Press Res. 2012 Jun 8;35(6):477-482
  • Johnson RJ, Sánchez-Lozada LG, Lanaspa MA. The fructose survival hypothesis as a mechanism for unifying the various obesity hypotheses. Obesity (Silver Spring). 2024 Jan;32(1):12-22. PubMed PMID: 37846155
  • Sánchez-Lozada LG, Madero M, Mazzali M, Feig DI, Nakagawa T, Lanaspa MA, Kanbay M, Kuwabara M, Rodriguez-Iturbe B, Johnson RJ. Sugar, salt, immunity and the cause of primary hypertension. Clin Kidney J. 2023 Aug;16(8):1239-1248. PubMed PMID: 37529651
  • Johnson RJ, Lanaspa MA, Sanchez-Lozada LG, Tolan D, Nakagawa T, Ishimoto T, Andres-Hernando A, Rodriguez-Iturbe B, Stenvinkel P. The fructose survival hypothesis for obesity. Philos Trans R Soc Lond B Biol Sci. 2023 Sep 11;378(1885):20220230. PubMed PMID: 37482773
  • Kalogeropoulu SK, Rauch-Schmücking H, Lloyd EJ, Stenvinkel P, Shiels PG, Johnson RJ, Fröbert O, Redtenbacher I, Burgener IA, Painer-Gigler J. Formerly bile-farmed bears as a model of accelerated ageing. Sci Rep. 2023 Jun 15;13(1):9691. PubMed PMID: 37322151
  • Stem AD, Rogers KL, Roede JR, Roncal-Jimenez CA, Johnson RJ, Brown JM. Sugarcane ash and sugarcane ash-derived silica nanoparticles alter cellular metabolism in human proximal tubular kidney cells. Environ Pollut. 2023 Sep 1;332:121951. PubMed PMID: 37301454
  • Andres-Hernando A, Orlicky DJ, Cicerchi C, Kuwabara M, Garcia GE, Nakagawa T, Sanchez-Lozada LG, Johnson RJ, Lanaspa MA. High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome. Biomolecules. 2023 Apr 30;13(5). PubMed PMID: 37238651
  • García-Arroyo FE, Gonzaga-Sánchez G, Silva-Palacios A, Roldán FJ, Loredo-Mendoza ML, Alvarez-Alvarez YQ, de Los Santos Coyotl JA, Vélez Orozco KA, Tapia E, Osorio-Alonso H, Arellano-Buendía AS, Sánchez-Gloria JL, Lanaspa MA, Johnson RJ, Sánchez-Lozada LG. Osthole Prevents Heart Damage Induced by Diet-Induced Metabolic Syndrome: Role of Fructokinase (KHK). Antioxidants (Basel). 2023 Apr 28;12(5). PubMed PMID: 37237888
  • Cara-Fuentes G, Verma R, Venkatareddy M, Bauer C, Piani F, Aksoy ST, Vazzalwar N, Garcia GE, Banks M, Ordoñez FA, de Lucas-Collantes C, Bjornstad P, González Rodríguez JD, Johnson RJ, Garg P. ß1-Integrin blockade prevents podocyte injury in experimental models of minimal change disease. Nefrologia (Engl Ed). 2023 May 5. [Epub ahead of print] PubMed PMID: 37150673
  • Schostak T, San Millan I, Jani A, Johnson RJ. Thiamine deficiency: a commonly unrecognised but easily treatable condition. Postgrad Med J. 2023 Aug;99(1174):844-848. PubMed PMID: 37125640
  • Andres-Hernando A, Cicerchi C, Garcia GE, Orlicky DJ, Stenvinkel P, Johnson RJ, Lanaspa MA. Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease. iScience. 2023 Apr 21;26(4):106355. PubMed PMID: 36994079
  • 467. Ejaz AA, Dass B, Kambhampati G, Ejaz NI, Maroz N, Dhatt GS, Arif AA, Faldu C, Lanaspan MA, Shah G, Johnson RJ. Lowering serum uric acid to prevent acute kidney injury. Medical Hypothesis 2012 Jun;78(6):796-9
  • 468. Ejaz AA, Kambhampati G, Ejaz NI, Dass B, Lapsia V, Arif AA, Asmar A, Shimada M, Alsabbagh MM, Aiyer R, Johnson RJ. Post-operative serum uric acid and acute kidney injury J Nephrol. 2012; 25:497-505
  • 469. Abdelmalak MF, Lazo M, Horska H, Bonnekamp S, Lipkin EW, Balasubramanyam A, Bantle JP,Johnson RJ, Diehl AM, Clark JM. Higher Dietary Fructose Is Associated with Impaired Hepatic ATP Homeostasis in Obese individuals with type 2 diabetes Hepatology 2012; 56:952-60
  • 470. Tamura Y, Tanabe K, Kitagawa W, Uchida S, Schreiner GF, Johnson RJ. Nakagawa T. Nicorandil, a KATP channel opener, alleviates chronic renal injury by targeting podocyte and macrophage. Am J Physiol Renal Physiol 2012 Aug;303(3):F339-49
  • Johnson RJ, Lee SMK, Sánchez-Lozada LG, Kanbay M, Bansal A, Tolan DR, Bjornstad P, Lanaspa MA, Maesaka J. Fructose: A New Variable to Consider in SIADH and the Hyponatremia Associated With Long-Distance Running?. Am J Kidney Dis. 2023 Jul;82(1):105-112. PubMed PMID: 36940740
  • 471. Wei X, Xu R, Yang Z, Liao Y, Johnson RJ, Yu X, Chen W. Novel uromodulin mutation in familial juvenile hyperuricaemic nephropathy Am J Nephrol 2012; 36:114-20
  • 472. Johnson RJ, Thomas J, Lanaspa MA. Impact of beverage intake on health and the kidneys. Nutrition Today 2012; 47:S22-S24
  • Rodriguez-Iturbe B, Johnson RJ, Sanchez-Lozada LG, Pons H. HSP70 and Primary Arterial Hypertension. Biomolecules. 2023 Feb 1;13(2). PubMed PMID: 36830641
  • Johnson RJ, Sanchez Lozada LG, Lanaspa MA, Piani F, Borghi C. Uric Acid and Chronic Kidney Disease: Still More to Do. Kidney Int Rep. 2023 Feb;8(2):229-239. PubMed PMID: 36815099
  • Johnson RJ, Tolan DR, Bredesen D, Nagel M, Sánchez-Lozada LG, Fini M, Burtis S, Lanaspa MA, Perlmutter D. Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?. Am J Clin Nutr. 2023 Mar;117(3):455-466. PubMed PMID: 36774227
  • Ejaz AA, Mohandas R, Beaver TM, Johnson RJ. A Crystal-Independent Role for Uric Acid in AKI Associated with Tumor Lysis Syndrome. J Am Soc Nephrol. 2023 Jan 1;34(1):175. PubMed PMID: 36719148
  • Kanbay M, Altintas A, Yavuz F, Copur S, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Responses to Hypoxia: How Fructose Metabolism and Hypoxia-Inducible Factor-1a Pathways Converge in Health and Disease. Curr Nutr Rep. 2023 Mar;12(1):181-190. PubMed PMID: 36708463
  • Johnson RJ, Warady BA. Does kidney transplant improve health-related quality of life for youth with chronic kidney disease?. Kidney Int. 2023 Feb;103(2):256-258. PubMed PMID: 36681454
  • Nakagawa T, Kang DH, Johnson RJ. An elevation in serum uric acid precedes the development of preeclampsia. Hypertens Res. 2023 Mar;46(3):809-811. PubMed PMID: 36646882
  • Nakagawa T, Ana Andres-Hernando, Kosugi T, Sanchez-Lozada LG, Stenvinkel P, Kublickiene K, Ananth Karumanchi S, Kang DH, Kojima H, Rodriguez-Iturbe B, Tolan DR, Lanaspa MA, Johnson RJ. Fructose might be a clue to the origin of preeclampsia insights from nature and evolution. Hypertens Res. 2023 Mar;46(3):646-653. PubMed PMID: 36539464
  • Stenvinkel P, Shiels PG, Johnson RJ. Lessons from evolution by natural selection: An unprecedented opportunity to use biomimetics to improve planetary health. J Environ Manage. 2023 Feb 15;328:116981. PubMed PMID: 36508982
  • Young SE, Khoshnaw LJ, Johnson RJ. Climate and the Nephrologist: The Intersection of Climate Change, Kidney Disease, and Clinical Care. Clin J Am Soc Nephrol. 2023 Mar 1;18(3):411-417. PubMed PMID: 36319069
  • 473. Kanbay M, Yilmaz MI, Sonmez A, Solak Y, Saglam M, Cakir E, Unal HU, Arslan E, Verim S, Magdalero M, McFann K, Johnson RJ. Serum uric acid independently predicts cardiovascular events in advanced nephropathy. Am J Nephrol 2012 Sep 22;36(4):324-331
  • Johnson RJ. Intestinal Hyperuricemia as a Driving Mechanism for CKD. Am J Kidney Dis. 2023 Feb;81(2):127-130. PubMed PMID: 36167757
  • Sasai F, Roncal-Jimenez C, Rogers K, Sato Y, Brown JM, Glaser J, Garcia G, Sanchez-Lozada LG, Rodriguez-Iturbe B, Dawson JB, Sorensen C, Hernando AA, Gonzalez-Quiroz M, Lanaspa M, Newman LS, Johnson RJ. Climate change and nephrology. Nephrol Dial Transplant. 2023 Jan 23;38(1):41-48. PubMed PMID: 34473287
  • 474. Li Z, Liu Q, Mao H, Li Z, Dong X, Liu Y, Lin J, Chen W, Wang H, Johnson RJ, Yu X, Chen W. Gender Difference in the Association of Hyperuricemia with Chronic Kidney Disease in Southern China. Kidney Blood Press Res. 2012 Aug 29;36(1):98-106
  • 475. Kretowicz M, Johnson RJ, Ishimoto T, Nakagawa T, Manitius J. The impact of fructose on renal function and blood pressure. Int J Nephrol 2011; Article ID 315879, pp1-5
  • 476. Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, Li N, Roncal-Jimenez CA, IshimotoT, Garcia GE, Thomas JB, Rivard CJ, Andres-Hernando A, Hunter B, Schreiner G, Rodriguez-Iturbe B, Sautin YY and Johnson RJ. Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. PLOS One 2012;7(10):e47948
  • 477. Lanaspa MA, Garcia G, Cicerchi C, Li N, Roncal-Jimenez CA, Rivard CJ, Hunter B, Andres-Hernando A, Ishimoto T, Sanchez-Lozada LG, Thomas J, Hodges RS, Mant CT, Johnson RJ.Counteracting Roles of AMP Deaminase and AMP kinase in the development of fatty liver. PLOS One 2012; 7(11):e48801
  • 478. Lanaspa MA, Sanchez-Lozada LG, Choi YJ, Cicerchi C, Kanbay M, Roncal-Jimenenz CA, Li N, Marek G, Duranay M, Schreiner G, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Sautin YY, Johnson RJ. Uric acid-induced hepatic steatosis is mediated by generation of mitochondrial oxidative stress and activation of NADPH oxidase. J Biol Chem 2012; 287 (48):40732-44
  • 479. Tanabe K, Tamura Y, Lanaspa MA, Miyazaki M, Suzuki N, Sato W, Maeshima Y, Scheiner GF, Villareal F, Johnson RJ, Nakagawa T. Epicatechin limnts renal injury by mitochondrial protection in cisplatin nephropathy. Am J Physiol Renal Physiol 2012; 40(9):1978-84
  • 480. Liu Q, Li Z, Wang H, Chen X, Dong X, Mao H, Tan J, Luo N, Johnson RJ, Chen W, Yu X, Chen W. High prevalence and associated risk factors for impaired renal function and urinary abnormalities in a rural adult population from southern China. PLoS One. 2012;7(10):e47100
  • 481. Sánchez-Lozada LG, Lanaspa-García MA, Cristóbal-García M, García-Arroyo F, Soto V, Cruz-Robles D, Nakagawa T, YuMA, Kang DH, Johnson RJ. Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations Nephron Exp Nephrol 2012 Dec 7;121(3-4):e71-e78
  • 482. Fini MA, Elias A, Johnson RJ, Wright RM. Contribution of uric acid to cancer risk recurrence and mortality Clinical Translational Medicine 2012; 1:16 (15 August 2012)
  • 483. Ejaz AA, Das B, Lingegowda V, Shimada M, Beaver TM, Ejaz N, Abouhamze M, Johnson RJ. Effect of Uric Acid lowering Therapy on the Prevention of Acute Kidney Injury in Cardiovascular Surgery. Int Urol Nephrol 2013 (in press)
  • 484. Hohenstein B, Daniel C, Johnson RJ, Amann KU, Hugo CPM. Platelets are not critical effector cells for the time course of murine passive crescentic glomerulonephritis. Platelets 2013 (in press)
  • 485. Huskey J, Rivard C, Myint H, Lucia S, Smith M, Shimada M, Ishimoto T, Araya C, Garin EH, Johnson RJ. Minimal Change Disease in Graft versus Host Disease: A Podocyte Response to the Graft? Clin Nephrol 2013 in press
  • 486. Johnson RJ, Rivard C, Lanaspa MA, Otabachian-Smith S, Ishimoto T, Cicerchi C, Cheeke PR, MacIntosh B, Hess T. Fructokinase, Fructans, Intestinal Permeability, and Metabolic Syndrome: An Equine Connection?? J Equ Vet Science 2013; 33:120-126
  • 487. Quiroz Y, Johnson RJ, Rodriguez-Iturbe B. The role of T cells in the pathogenesis of primary hypertension. Nephrol Dial Transpl 2012; 27 (Suppl4):iv2-5
  • 488. Johnson RJ, Stenvkinkel P, Martin SL, Sanchez-Lozada LG, Hill JO, Lanaspa MA Redefining Metabolic Syndrome as a Fat Storage Condition Based on Studies of Comparative Physiology. Obesity 2013 (in press)
  • 489. Rivard C, Thomas J, Lanaspa MA and Johnson RJ. ‘Sack and Sugar’, and the Aetiology of Gout in England between 1650 and 1900. Rheumatology (Oxford) 2013; 52:421-26
  • 490. Hurtado A., Escudero E. Pando J, Sharma S, Johnson RJ. Cardiovascular and Renal effects of Chronic Exposure to High Altitude. Nephrol Dial Transpl 2012 Dec; 27 Suppl4:iv11-16
  • 491. Rodriguez-Iturbe B, Franco M, Johnson RJ. Impaired pressure natruiruresis is associated with interstitial inflammation in salt-sensitive hypertension. Curr Opn Nephrol Hypertens 2013, 22:37–44
  • 492. Sirota JC, McFann K, Targher G, Johnson RJ, Chonchol M, Jalal DI. Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism 2013 Mar; 62:392-9
  • 493. Stenvinkel P, Jani A, Johnson RJ. Hibernating bears (Ursidae) – Metabolic Magicians of definite interest for the Nephrologist. Kidney Int 2013 Feb; 83:207-212.
  • 494. Turak O, Ozcan F, Tok D, Isleyen A, Sokmen E, Tasoglu I, Aydogdu, S, Seri N, McFann K, Johnson RJ, Kanbay M. Serum Uric Acid, Inflammation and Nondipping Circadian Pattern in Essential Hypertension. J Clin Hypertens 2013 Jan; 15:7-13.
  • 495. Ishimoto T, Shimada M, Garcia G, Kosugi T, Sato W, Lee P, Lanasap M, Rivard C, Garin, E,Johnson RJ. Toll-like receptor 3 ligand, polyIC, induces proteinuria and glomerular CD80, and increases urinary CD80 in mice. Nephrol Dial Transpl 2013 (in press)
  • 496. Pons H, Ferrebu A, Quiroz Y, Romero F, Parra G, Johnson RJ, Rodriguez-Iturbe B. Immune reactivity to heat shock protein 70 Expressed in the Kidney is Cause of Salt-sensitive Hypertension. Am J Physiol Renal Physiol 2013 (Feb); 304:F289-99
  • 497. Kanbay M, Segal M, Afsar B, Kang DH, Rodriguez-Iturbe B, Johnson RJ. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart 2013 (in press)
  • 498. Le MT, Lobmeyer MT, Campbell M, Cheng J, Wang Z, Turner ST, Chapman AB, Boerwinkle E, Gums JG, Gong Y, Johnson RJ, Johnson JA. Impact of genetic polymorphisms of SLC2Aa2, SlC2A5, and KHK on metabolic phenotypes in hypertensive individuals. PLOS One 2013; 8(1):e52062
  • 499. Inaba S, Sautin YY, Garcia GE, Johnson RJ. What can asymptomatic hyperuricemia and systemic inflammation in the absence of gout tell us? Rheumatology (Oxford) in press
  • 500. Feig DI, Madero M, Jalal DI, Sanchez-Lozada LG, Johnson RJ. Uric acid and the origin of hypertension. J Peds 2013 (in press)
  • 501. Ryu ES, Kim MJ, Shin HS, Jang YH, Choi HS, Johnson RJ, Kang DH. Uric Acid-induced Phenotypic Transition of Renal Tubular Cells as a Novel Mechanism of Chronic Kidney Disease. Am J Physiol Renal Physiol 2013 (in press)
  • 502. Vasiliou V, Sandova M, Backos DS, Jackson BC, Chen Y, Reiga P, Lanaspa M, Johnson RJ, Koppaka V and Thompson DC. ALDH16A1 is a novel non-catalyic protein that may be involved in the etiology of gout via protein-protein interactions with HPRT1. Chemico-Biol Interactions 2013 (in press)
  • 503. Franco M, Edilia T, Pacheco U, Bautista R, Santamaria J, Quiroz Y, Johnson RJ, Rodriguea-Iturbe B. Impaired pressure natriuresis resulting in salt-sensitive hypertension is caused by tubulointerstital immune cell infiltration in the kidney. Am J Physiol Renal Physiol 2013(in press)
  • 504. Tapia E, Cristobal M, Garcia-Aroyo FE, Soto V, Monroy-Sanchez F, Pacheco U, Lanaspa MA, Roncal-Jimenez C, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sanchez Lozada LG. Synergistic effect of uricase blockade plus physiologic amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol (in press)
  • 505. Schroff RC, Price KL, Kolatsi-Joannour, Todd AF, Wells D, Deanfield J, Johnson RJ, Rees L, Long DA. Circulating angiopoietin-2 is a biomarker for early cardiovascular disease in children on long-term dialysis. PLOS One 2013; 8(2):e56273
  • 506. Johnson RJ, Sanchez-Lozada LG, Mazzali M, Feig DI, Kanbay M, Sautin YY. What are the key arguments against uric acid as a true risk factor for hypertension? Hypertension (invited) (in press)
  • 507. Johnson RJ, Nakagawa T, Jalal D, Sanchez-Lozada LG, Kang DH, Ritz E. Uric acid and chronic kidney disease: Which is chasing which? Nephrol Dial Transpl (in press)
  • 508. Lotan Y, Daudon M, Bruyère F, Talaska G, Strippoli G, Johnson RJ, Tack I Impact of fluid intake in the prevention of urinary system diseases. A brief review. Curr Opin Nephrol Hypertens (in press)
  • 509. Eckardt KU, Coresh J, Devuyst O, Johnson RJ, Kottgen A, Levin A, Levy A. The evolving importance of kidney disease – from a subspecialty focus to a global health burden. The Lancet (in press)
  • 510. Maahs DM, Jalal D, Chonchol M, Johnson RJ, Rewers M, Snell-Bergeon JI. Impaired renal function further increases odds of 6 year coronary artery calcification progression in adults with type 1 diabetes: the Cacti Study. Diabetes Care (in press)
  • 66. Johnson RJ, Lanaspa MA, Roncal-Jimenez C, Sanchez-Lozada LG Effects of excessive fructose intake on health. Annals of Internal Medicine 2012 Jun 19;156(12):905 (Letter)
  • 67. Madero M, Sanchez-Lozada LG, Johnson RJ. Fructose likely does have a role in hypertension. Hypertension 2012 Jun;59(6):e54 (letter to editor)
  • 68. Johnson RJ, Bakris GL, Rodriguez-Iturbe B. Primary Hypertension, in Comprehensive Clinical Nephrology, edition 5, Johnson RJ, Floege J and Feehally J, editors. Elsevier 2013
  • 69. Johnson RJ, Floege J, Feehally J. Introduction to Glomerular Disease: Histologic Classification and Pathogenesis, in Comprehensive Clinical Nephrology, edition 5, Johnson RJ, Floege J and Feehally J, editors. Elsevier 2013
  • 70. Kanbay M, Turak O, Johnson RJ. Reply to Serum Uric Acid Still Carries Controversies about its Role in Endothelial Dysfunction J Clin Hypertens 2013(letter)

Professional Memberships

  • American Heart Association (AHA), Member
  • American Society of Clinical Investigation, Member
  • American Society of Nephrology, Member
  • American College of Physicians (ACP), Fellow
  • American Federation of Clinical Research, Member
  • International Society of Nephrology, Member
  • Australian & New Zealand Society of Nephrology, Honorary Member
  • Association of Subspecialty Professors, Member
  • American Physiological Society, Member
  • Archaeological Institute of America, Member
  • National Kidney Foundation, Member
  • American Diabetes Association, Member
  • Western Association of Physicians, Member
  • Polish Society of Nephrology , Honorary Member

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1982)
  • Nephrology, Board Certification (1984)
  • Infectious Disease, Board Certification (1986)
Personal Interests
Role of Sugar and Uric acid in Metabolic Health

Public Speaking
Yes
Obesity, Kidney Disease, Diabetes, Nutrition


School of Medicine

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Aurora, CO 80045

303.724.5375

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