Marilee Wick, PhD

Publications

• Wick MJ, Barr EJ, Wehling CA, Miller, YE, Voelkel NF, Dempsey EC. Lung Neprilysin Activity and Expression are Decreased in a Human Model of Chronic Hypoxic Pulmonary Hypertension. 2007. Am J Resp Crit Care Med, in press
• Wick MJ, Barr EJ, Wehling CA, Miller, YE, Voelkel NF, Dempsey EC. Lung Neprilysin Activity and Expression are Decreased in a Human Model of Chronic Hypoxic Pulmonary Hypertension. (In preparation) 2007.
• Dempsey EC, Tallman DW, Wehling CA, Karoor V, Fagan KA, Cool CD, Wick MJ, Morris KG, Jr., Le M, Hersh L, Gerard N, Gerard C, Miller YE. Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. (In preparation) 2007.
• Wick, M.J., Barr, E.J., Wehling, C.A., Miller, Y.E., Voelkel, N.F. and Dempsey, E.C. Lung Neprilysin Activity and Expression are Decreased in a Human Model of Chronic Hypoxic Pulmonary Hypertension. Presentation at 2007 ATS meeting; Am. J. Respir. Crit. Care Med. 2007, 175: A44.
• Dempsey, E.C., Wick, M.J., Karoor, V., Barr, E.J., Tallman, D.W., Wehling, C.A., Sandra J. Walchak, S.J., Laudi, S., Le, M., Oka, M., Majka, S., Cool, C.D., Fagan, K.A., Klemm, D.J., Hersh, L.B., Gerard, N.P., Gerard, C. and Miller, Y.E. (2008) Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia (Submitted).
• Wick, M.J., Barr, E.J., Wehling, C.A., Cool, C.D., Miller, Y.E., Hersh, L.B., Voelkel, N.F. and Dempsey, E.C. (2008) Lung Neprilysin Activity and Expression are Decreased in a Human Model of Chronic Hypoxic Pulmonary Hypertension (In preparation).
• Wick, M.J., Barr, E.J., Wehling, C.A., Cool, Zamora, M., C.D., Miller, Y.E., Hersh, L.B., Voelkel, N.F. and Dempsey, E.C. Lung Neprilysin Activity and Expression are Decreased in Humans with COPD and Pulmonary Vascular Remodeling. 2009 Exp. Biol. Meeting, FASEB J. 968, 770.3 (2009)
• Dempsey, E.C., Wick, M.J., Karoor, V., Barr, E.J., Tallman, D.W., Wehling, C.A., Sandra J. Walchak, S.J., Laudi, S., Le, M., Oka, M., Majka, S., Cool, C.D., Fagan, K.A., Klemm, D.J., Hersh, L.B., Gerard, N.P., Gerard, C. and Miller, Y.E. Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia. Am J. Pathol. (2009) 174: 782-796
• Wick, M.J., Barr, E.J., Wehling, C.A., Cool, C.D., Zamora, M., Miller, Y.E., Hersh, L.B., Voelkel, N.F. and Dempsey, E.C. (2008) Lung Neprilysin Activity and Expression are Decreased in a Human Model of Pulmonary Vascular Remodeling (In Preparation)
• Wick, M.J., Barr, E.J., Wehling, C.A., Loomis, Z.L., Cool, C.D., Zamora, M.R., Miller, Y. E., Colgan, S.P., Hersh, L.B., Voelkel, N.F., and Dempsey, E.C. (2010) Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease. Am J.Resp. Crit. Care Med., Submitted for publication.
• Wick, M.J., Miller, Y.E., and Dempsey, E.C., (2010) Neprilysin Peptidase-Independent Complex Formation In Pulmonary Artery Smooth Muscle Cells. Accepted for presentation at 2010 EB meeting.
• Wick, M.J., Barr, E.J., Wehling, C.A., Loomis, Z.L., Cool, C.D., Miller, Y. E., Hersh, L.B., Voelkel, N.F., and Dempsey, E.C. (2010) Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease. Accepted for presentation at 2010 ATS meeting.
• Wick, M.J., Buesing, E.J., Wehling, C.A., Loomis, Z.L., Cool, C.D., Zamora, M.R., Miller, Y. E., Colgan, S.P., Hersh, L.B., Voelkel, N.F., and Dempsey, E.C. (2011) Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease. Am J.Resp. Crit. Care Med.,183; 330-340.
• Dempsey, E.C., Loomis, Z.L., Wick, M.J. (2011) Recent Advances in Lung Neuropeptide Biology Using Neprilysin and VIP Knockout Mice. Drug Discovery Today, Disease Models. In press.
• Wick, M.J., Loomis, Z.L., Buesing, E.J., Wehling, C.A., Cool, C.D., Hersh, L.B., Voelkel, N.F., and Dempsey, E.C. (2011) Decreased lung neprilysin gene expression in humans with COPD and pulmonary vascular remodeling. 2011 EB meeting.
• Wick, M.J., Dempsey, E.C., Loomis, Z.L. (2011) Neprilysin and Pulmonary Vascular Remodeling in COPD: Peptidase-Independent Complex Formation. 2011 ATS meeting.
• Dempsey, E.C., Loomis, Z.L. and Wick, M.J., (2011) Recent Advances in Lung Neuropeptide Biology Using Neprilysin and VIP Knockout Mice. Drug Discovery Today, Disease Models. 7: 67-75.
• Maloney, J.P., Stearman, R.S., Bull, T.M., Calabrese, D.W., Tripp-Addison, M.L., Wick, M.J., Chuckran, A., Broeckel, U., Robbins, I.M., Wheeler, L.A., Cogan, J.D., and Loyd, J.E. (2012) Loss of Function Thrombospondin-1 Mutations in Familial Pulmonary Hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. In Press.
• Wick, M.J., Loomis, Z.L., Hersh, L.B., and Dempsey, E.C. (2012) Mechanisms that decrease human Neprilysin gene expression in cigarette smoke-induced pulmonary vascular disease. 2012 Experimental Biology meeting. In press.
• Maloney, J.P., Stearman, R.S., Bull, T.M., Calabrese, D.W., Tripp-Addison, M.L., Wick, M.J., Chuckran, A., Broeckel, U., Robbins, I.M., Wheeler, L.A., Cogan, J.D., and Loyd, J.E. Loss of Function Thrombospondin-1 Mutations in Familial Pulmonary Hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol., 302: L541-L554, 2012
• Wick, M.J., Loomis, Z.L., Hersh, L.B., and Dempsey, E.C. Mechanisms that decrease human Neprilysin gene expression in cigarette smoke-induced pulmonary vascular disease. FASEB J. 26:873.12, 2012
• Wick, M.J., Loomis, Z.L., Buesing, E.J., Wehling, C.A., Cool, C.D., Hersh, L.B., Voelkel, N.F., and Dempsey, E.C. (2013) Decreased lung neprilysin gene expression in humans with COPD and pulmonary vascular remodeling. Eastern Colorado Health Care System, VA Research Days, May 30, 2013.
• Methods to Assess Tissue and Cell Neprilysin Activity and Expression. Wick, M.J., Loomis, Z. L., Dempsey, E. C., in preparation.
• Neprilysin Transgenic Mouse with Complex Overexpression Pattern and Protection Against Vascular Leak. Wick, M.J., Loomis, Z.L., Le, M., Miller, Y.M., Dempsey, E.C., in preparation.
• Neprilysin transgenic mouse with complex overexpression pattern and protection against vascular leak Wick, M., Loomis, ZL, Harral, JW, Le, Wehling,CA, Miller, YE, and Dempsey, EC. Transgenic Res., 2016.
• Assessment and implications of tissue and cell Neprilysin activity and expression. Wick, MJ, Loomis, Z L, Dempsey, EC. Advances in Enzyme Research, 2016.
• Neprilysin transgenic mouse with complex over expression pattern. Wick, M.J., Loomis, Z.L., Harral, J., Le, M, Miller Y.E., and Dempsey, E.C. (2015).
• Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern. Wick, M.J., Loomis, Z.L., Harral, J.W., Le M., Wehling, C.A., Miller, Y.E., and Dempsey, E.C.Transgenic Research, 25(6): 773-784, 2016. DOI 10.1007/s11248-016-9969-x.
• Negative regulation of pulmonary neprilysin expression by cigarette smoke. Wick, MJ, Loomis, ZL, and Dempsey EC. (2017)
• Protection against vascular leak in neprilysin transgenic mice with a complex over expression pattern. Wick, M.J., Loomis, Z.L., Harral, J.W., Le M., Wehling, C.A., Miller, Y.E., and Dempsey, E.C.
• Measurement of vascular leak in selected tissues of the mouse. Wick, M.J., Loomis, Z.L., Harral, J.W., and Dempsey, E.C. J. Vis Exp. (2017).
• Wick,M.J., Harral,J.W., Loomis, Z.L., and Dempsey, E.C., (2018) An optimized Evans blue protocol to assess vascular leak in the mouse. J. Vis. Exp. (JoVE), accepted for publication and filming completed.
• Negative regulation of neprilysin in smoke- and hypoxia-induced pulmonary hypertension