Paul Maclean, PhD

MacLean PS, Jackman M, Bessesen DH. Compensatory response to reducing weight. Drug Discovery Today: Disease Mechanisms 2(3):313-319, 2005.

MacLean PS, Higgins JA, Jackman M, Johnson GC, Fleming-Elder BK, Wyatt H, Melanson EL, Hill JO. Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol (in press, 2006).

Morris EM, Jackman MR, Meers GM, Johnson GC, Lopez JL, MacLean PS, Thyfault JP. Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1a overexpression. Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G868-80. PubMed PMID: 24091599

Crunk AE, Monks J, Murakami A, Jackman M, Maclean PS, Ladinsky M, Bales ES, Cain S, Orlicky DJ, McManaman JL. Dynamic regulation of hepatic lipid droplet properties by diet. PLoS One. 2013;8(7):e67631. PubMed PMID: 23874434

MacLean, PS, Higgins JA, Jackman MR, Johnson GC, Fleming-Elder BK, Roper MD, Friedman JE, Klemann LP, Finley JW. Saturated fats enhance metabolic efficiency and reduce lipid utilization in the context of a low carbohydrate, energy-restricted diet. Nutrition and Metabolism Society, Brooklyn, 2006.

Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov;58(5):1632-43. PubMed PMID: 23813872

Qiao L, MacLean PS, You H, Schaack J, Shao J. Knocking down liver C/EBPa by adenovirus-transduced siRNA improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology (in press, 2006).

MacLean PS, Higgins JA, Jackman M, Johnson GC, Fleming-Elder BK, Wyatt H, Melanson EL, Hill JO. Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol 290:1577-1588, 2006.

Strohacker K, McCaffery JM, Maclean PS, Wing RR. Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature. Int J Obes (Lond). 2014 Mar;38(3):388-96. PubMed PMID: 23801147

Qiao L, MacLean PS, You H, Schaack J, Shao J. Knocking down liver C/EBPa by adenovirus-transduced siRNA improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology 147(6):3060-3069, 2006.

McManaman JL, Bales ES, Orlicky DJ, Jackman M, MacLean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS. Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res. 2013 May;54(5):1346-59. PubMed PMID: 23402988

? Jackman MR, Kramer R, MacLean PS, Bessesen DH. Trafficking of dietary fat in obesity prone and obesity resistant rats. Am J Physiol Endocrinol Metab 291: E1083-E1091, 2006.

MacLean, PS. Expanding the Target for Obesity Therapeutics. Metabolic Diseases World Summit, Long Beach, 2006.

Jankowski CM, Gozansky WS, MacLean PS, Shulman B, Wolfe P, Schwartz RS, Kohrt WM. N-acetyl-4-aminophenol and musculoskeletal adaptations to resistance exercise training. Eur J Appl Physiol. 2013 May;113(5):1127-36. PubMed PMID: 23108581

Pender JR, Barakat HA, MacDonald KG, Chapman WH, Dohm GL, MacLean PS, Hickner RC, Pories WJ. Racial Variations in fat metabolism may affect the success of diets and bariatric surgery. American Society for Bariatric Surgery, San Francisco, 2006.

MacLean PS, Higgins JA, Jackman MR, Johnson GC, Fleming-Elder BK, Wyatt H, Melanson EL, Brown IL, Hill JO. Metabolic responses to prolonged weight reduction that promote rapid, efficient regain, Kern Aspen Lipid Conference, Aspen, 2006.

Jackman, MR, Kramer R, MacLean PS, Bessesen DH. Trafficking of dietary fat in obesity prone and obesity resistant rats. Kern Aspen Lipid Conference, Aspen, 2006.

MacLean PS, Rudolph MC, Jackman MR, Fleming BK, Johnson GC, Higgins JA, Hill JO, Neville MC. Weight reduction alters skeletal muscle expression of metabolic pathway genes in a manner that promotes energetically efficient fuel utilization and weight regain. International Conference on Obesity, Sydney, 2006.

MacLean PS, Higgins JA, Giles ED, Sherk VD, Jackman MR. The role for adipose tissue in weight regain after weight loss. Obes Rev. 2015 Feb;16 Suppl 1:45-54. PubMed PMID: 25614203

Irwin DC, Garat CV, Crossno JT Jr, MacLean PS, Sullivan TM, Erickson PF, Jackman MR, Harral JW, Reusch JE, Klemm DJ. Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia. Pulm Circ. 2014 Dec;4(4):638-53. PubMed PMID: 25610600

MacLean PS, Wing RR, Davidson T, Epstein L, Goodpaster B, Hall KD, Levin BE, Perri MG, Rolls BJ, Rosenbaum M, Rothman AJ, Ryan D. NIH working group report: Innovative research to improve maintenance of weight loss. Obesity (Silver Spring). 2015 Jan;23(1):7-15. PubMed PMID: 25469998

Morris EM, Jackman MR, Johnson GC, Liu TW, Lopez JL, Kearney ML, Fletcher JA, Meers GM, Koch LG, Britton SL, Rector RS, Ibdah JA, MacLean PS, Thyfault JP. Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis. Am J Physiol Endocrinol Metab. 2014 Aug 15;307(4):E355-64. PubMed PMID: 24961240

Saben JL, Bales ES, Jackman MR, Orlicky D, MacLean PS, McManaman JL. Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis. PLoS One. 2014;9(5):e98066. PubMed PMID: 24849657

Strohacker K, McCaffery JM, MacLean PS, Wing RR. Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature. Int J Obes (Lond). 2014 Mar;38(3):388-96. PubMed PMID: 23801147

Higgins JA, MacLean PS, Johnston GC, Fleming-Elder BK, Wyatt HR, Brown IL. The effect of starch subtypes on energy metabolism. Australian Cereal Chemistry Conference, Perth, 2006.

Gilman KA, Schedin P, MacLean PS. Obesity alters mammary tumor survival and estrogen receptor status after ovariectomy. AFMR Meetings, Carmel, 2007.

Jackman MJ, Johnson GC, Fleming-Elder BK, Bessesen DH, MacLean PS. Enhanced metabolic flexibility with long term weight reduction facilitates weight regain in obesity-prone rats. Accepted for Experimental Biology, Washington DC, 2007.

MacLean PS, Gilman KA, Johnson GC, Andrianakos AG, Fleming-Elder BK, McDaniel SM, Jackman MR, Shroyer KG, Schedin PJ. Obesity enhances mammary tumor progression in ovariectomized rats. Submitted for Endocrinology, Toronto, 2007.

Sladek CD, Stevens W, Song Z, Johnson GC, MacLean PS. The 'Metabolic Sensor' Function of Rat Supraoptic Oxytocin and Vasopressin Neurons is Attenuated during Lactation but not in Diet-Induced Obesity. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 9;:ajpregu.00422.2015. [Epub ahead of print] PubMed PMID: 26661099

Frank DN, Bales ES, Monks J, Jackman MJ, MacLean PS, Ir D, Robertson CE, Orlicky DJ, McManaman JL. Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine. PLoS One. 2015;10(7):e0131944. PubMed PMID: 26147095

MacLean PS, Higgins JA, Giles ED, Sherk VD, Jackman MR. The role for adipose tissue in weight regain after weight loss. Obes Rev. 2015 Feb;16 Suppl 1:45-54. PubMed PMID: 25614203

Civitarese AE, MacLean PS, Carling S, Moro C, Pierce A, Wang Z, Bayless L, Cefalu W, Becker TC, Newgard CB, Walder K, Collier GR, Smith SR, and Ravussin E. Regulation of Skeletal Muscle Oxidative Capacity and Insulin Signaling by the Mitochondrial Protease PARL. North American Association for the Study of Obesity, New Orleans, 2007.

MacLean PS, Wing RR, Davidson T, Epstein L, Goodpaster B, Hall KD, Levin BE, Perri MG, Rolls BJ, Rosenbaum M, Rothman AJ, Ryan D. NIH working group report: Innovative research to improve maintenance of weight loss. Obesity (Silver Spring). 2015 Jan;23(1):7-15. PubMed PMID: 25469998

Jackman MJ, Johnson GC, Fleming-Elder BK, Bessesen DH, MacLean PS. Enhanced metabolic flexibility with long term weight reduction facilitates weight regain in obesity-prone rats. Experimental Biology, Washington DC, 2007.

MacLean PS, Gilman KA, Johnson GC, Andrianakos AG, Fleming-Elder BK, McDaniel SM, Jackman MR, Shroyer KG, Schedin PJ. Obesity enhances mammary tumor progression in ovariectomized rats. Endocrinology, Toronto, 2007.

MacLean PS, Blundell JE, Mennella JA, Batterham RL. Biological control of appetite: A daunting complexity. Obesity (Silver Spring). 2017 Mar;25 Suppl 1:S8-S16. PubMed PMID: 28229538

Checkley LA, Rudolph MC, Wellberg EA, Giles ED, Wahdan-Alaswad RS, Houck JA, Edgerton SM, Thor AD, Schedin P, Anderson SM, MacLean PS. Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo . Cancer Prev Res (Phila). 2017 Mar;10(3):198-207. PubMed PMID: 28154203

Sherk VD, Carpenter RD, Giles ED, Higgins JA, Oljira RM, Johnson GC, Mills S, MacLean PS. Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training. Med Sci Sports Exerc. 2017 Jan 10. [Epub ahead of print] PubMed PMID: 28079706

Giles ED, Jackman MR, MacLean PS. Modeling Diet-Induced Obesity with Obesity-Prone Rats: Implications for Studies in Females. Front Nutr. 2016 Nov 24;3:50. PubMed PMID: 27933296

Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2016 Dec 13. [Epub ahead of print] PubMed PMID: 27876761

Melanson E, Bessesen D, Cornier M, MacLean P, Grunwald, G, Hill JO. Resting metabolic rate following diet-induced weight loss. North American Association for the Study of Obesity, New Orleans, 2007.

Fleming-Elder BK, Steig A, Johnson GC, Melanson E, Jackman MJ, Wyatt H, Higgins JA, Hill JO, MacLean PS. Regular exercise in weight-reduced, obesity-prone rats attenuates weight regain on a high fat diet. North American Association for the Study of Obesity, New Orleans, 2007.

Johnson GC, Higgins JA, Steig A, Jackman MJ, Fleming-Elder BK, Brown I, Hill JO, MacLean PS. Resistant starch attenuates weight regain on a high fat diet after long term weight reduction. North American Association for the Study of Obesity, New Orleans, 2007.

Jackman MJ, Steig A, Johnson GC, Fleming-Elder BK, Higgins JA, Bessesen DH, MacLean PS. Dietary fat is trafficked away from oxidation and toward visceral adipose tissue after long term weight reduction. North American Association for the Study of Obesity, New Orleans, 2007.

Jensen DR, Knaub LA, Konhilas JP, MacLean PS, Eckel RH. Increased Thermoregulation in Cold Exposed Transgenic Mice Overexpressing Lipoprotein Lipase in Skeletal Muscle: An Avian Phenotype? J Lipid Res (in press).

Song ??? Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, Oppelt SA, Kuwabara M, Jensen T, Milagres T, Andres-Hernando A, Ishimoto T, Garcia GE, Johnson G, MacLean PS, Sanchez-Lozada LG, Tolan DR, Johnson RJ. Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice. J Neurophysiol. 2017 Feb 1;117(2):646-654. PubMed PMID: 27852737

Rudolph MC, Young BE, Jackson KH, Krebs NF, Harris WS, MacLean PS. Human Milk Fatty Acid Composition: Comparison of Novel Dried Milk Spot Versus Standard Liquid Extraction Methods. J Mammary Gland Biol Neoplasia. 2016 Dec;21(3-4):131-138. PubMed PMID: 27796616

Catenacci VA, Pan Z, Ostendorf D, Brannon S, Gozansky WS, Mattson MP, Martin B, MacLean PS, Melanson EL, Troy Donahoo W. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (Silver Spring). 2016 Sep;24(9):1874-83. PubMed PMID: 27569118

Jackman MR, Steig A, Higgins JA, Johnson GC, Fleming-Elder BK, Bessesen DH, MacLean PS. Weight Regain After Sustained Weight Reduction is Accompanied by Suppressed Oxidation of Dietary Fat and Adipocyte Hyperplasia. Am J Physiol Regul Integr Comp Physiol (in press).

Matthew Morris E, Meers GM, Koch LG, Britton SL, MacLean PS, Thyfault JP. Increased aerobic capacity reduces susceptibility to acute high-fat diet-induced weight gain. Obesity (Silver Spring). 2016 Sep;24(9):1929-37. PubMed PMID: 27465260

Jackman MR, Steig A, Higgins JA, Johnson GC, Fleming-Elder BK, Bessesen DH, MacLean PS. Weight Regain After Sustained Weight Reduction is Accompanied by Suppressed Oxidation of Dietary Fat and Adipocyte Hyperplasia. Am J Physiol Regul Integr Comp Physiol 294: R1117-R1129, 2008.

Giles ED, Hagman J, Pan Z, MacLean PS, Higgins JA. Weight restoration on a high carbohydrate refeeding diet promotes rapid weight regain and hepatic lipid accumulation in female anorexic rats. Nutr Metab (Lond). 2016 Mar 1;13:18. PubMed PMID: 26937246

Giles ED, Steig AJ, Jackman MR, Higgins JA, Johnson GC, Lindstrom RC, MacLean PS. Exercise Decreases Lipogenic Gene Expression in Adipose Tissue and Alters Adipocyte Cellularity during Weight Regain After Weight Loss. Front Physiol. 2016 Feb 10;7:32. PubMed PMID: 26903882

Sladek CD, Stevens W, Song Z, Johnson GC, MacLean PS. The "metabolic sensor" function of rat supraoptic oxytocin and vasopressin neurons is attenuated during lactation but not in diet-induced obesity. Am J Physiol Regul Integr Comp Physiol. 2016 Feb 15;310(4):R337-45. PubMed PMID: 26661099

Melanson EL, MacLean PS, Hill JO. Exercise Improves Fat Metabolism in Muscle But Does Not Increase 24-h Fat Oxidation. Exerc Sports Sci Rev (in press, 2009).

MacLean PS, Giles ED, Johnson GC, McDaniel SM, Fleming-Elder BK, Gilman KA, Andrianakos AG, Jackman AR, Shroyer KR, Schedin PJ. A surprising link between the energetics of weight gain and mammary tumor progression in a model of postmenopausal obesity. Obesity (in revision).

Rosenbaum M, Agurs-Collins T, Bray MS, Hall KD, Hopkins M, Laughlin M, MacLean PS, Maruvada P, Savage CR, Small DM, Stoeckel L. Accumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain. Obesity (Silver Spring). 2018 Apr;26 Suppl 2:S25-S34. PubMed PMID: 29575784

MacLean PS, Rothman AJ, Nicastro HL, Czajkowski SM, Agurs-Collins T, Rice EL, Courcoulas AP, Ryan DH, Bessesen DH, Loria CM. The Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) Core Measures Project: Rationale and Approach. Obesity (Silver Spring). 2018 Apr;26 Suppl 2:S6-S15. PubMed PMID: 29575780

MacLean PS, Higgins JA, Jackman MR, Giles ED, Steig AJ, Wyatt H, Melanson E, Johnson GC, Brown I, Eckel RH, Hill JO. Regular exercise: a counter to biology’s drive to regain lost weight. Science (in review).

Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3138-3143. PubMed PMID: 29507217

Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC. Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight. 2018 Feb 8;3(3). [Epub ahead of print] PubMed PMID: 29415895

MacLean PS, Higgins JA, Wyatt H, Melanson E, Johnson GC, Jackman MR, Giles ED, Brown I, Hill JO. Regular exercise attenuates the metabolic drive to regain weight after long term weight loss. Am J Physiol Regul Integr Comp 297(3):R793-802, 2009. PMID: 19587114, PMC2739786

MacLean PS, Giles ED, Johnson GC, McDaniel SM, Fleming-Elder BK, Gilman KA, Andrianakos AG, Jackman AR, Shroyer KR, Schedin PJ. A surprising link between the energetics of weight gain and mammary tumor progression in a model of postmenopausal obesity. Obesity (in press, 2009).

Melanson EL, Gozansky WS, Barry DW, Maclean PS, Grunwald GK, Hill JO. When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals. J Appl Physiol 107(6):1847-56, 2009. PMID: 19833807

Civitarese AE, MacLean PS, Carling S, Moro C, Pierce A, Wang Z, Bayless L, Cefalu W, Becker TC, Newgard CB, Walder K, Collier GR, Smith SR, and Ravussin E. Regulation of Skeletal Muscle Oxidative Capacity and Insulin Signaling by the Mitochondrial Protease PARL. Cell Metab (accepted, 2010).

Foright RM, Presby DM, Sherk VD, Kahn D, Checkley LA, Giles ED, Bergouignan A, Higgins JA, Jackman MR, Hill JO, MacLean PS. Is regular exercise an effective strategy for weight loss maintenance?. Physiol Behav. 2018 May 1;188:86-93. PubMed PMID: 29382563

Rudolph MC, Jackman MR, Presby DM, Houck JA, Webb PG, Johnson GC, Soderborg TK, de la Houssaye BA, Yang IV, Friedman JE, MacLean PS. Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance. Diabetes. 2018 Apr;67(4):651-661. PubMed PMID: 29138256

Wellberg EA, Checkley LA, Giles ED, Johnson SJ, Oljira R, Wahdan-Alaswad R, Foright RM, Dooley G, Edgerton SM, Jindal S, Johnson GC, Richer JK, Kabos P, Thor AD, Schedin P, MacLean PS, Anderson SM. The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer. Horm Cancer. 2017 Dec;8(5-6):269-285. PubMed PMID: 28741260

Sherk VD, Jackman MR, Giles ED, Higgins JA, Foright RM, Presby DM, Johnson GC, Houck JA, Houser JL, Oljira R, MacLean PS. Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function. Physiol Rep. 2017 May;5(10). PubMed PMID: 28533263

Wahlig J, Bales E, Jackman M, Johnson G, MacLean P, McManaman J. Differences in whole body metabolism and nutrient utilization in obese and lean mice; Effects on lactation. Rocky Mountain Reproductive Sciences Symposium, Fort Collins, Colorado, 2009.

Giles ED, Steig AJ, Jackman MR, Higgins JA, Johnson GC, Mahan MC, Wyatt HR, Eckel RH , Hill JO, MacLean PS. Exercise reduces trafficking of dietary fat to adipose tissue during the relapse to obesity. FASEB Summer Research Conference, “The Physiological Basis for Obesity Therapeutics.” Snowmass, Colorado, 2009.

MacLean PS, Blundell JE, Mennella JA, Batterham RL. Biological control of appetite: A daunting complexity. Obesity (Silver Spring). 2017 Mar;25 Suppl 1:S8-S16. PubMed PMID: 28229538

Houser JL, Giles ED, Johnson GC, Mahan MC, Jackman MR, Higgins JA, Schedin PJ, MacLean PS. Energy balance, fuel utilization, and activity levels in lean and obese rats before and after surgical ovariectomy. FASEB Summer Research Conference, “The Physiological Basis for Obesity Therapeutics.” Snowmass, Colorado, 2009.

Wahlig J, Bales E, Jackman M, Johnson G, McManaman J, MacLean P. The Effects of Maternal Obesity on Energy Balance, Dietary Fat Trafficking, and De Novo Lipogenesis During Lactation. FASEB Summer Research Conference, “The Physiological Basis for Obesity Therapeutics.” Snowmass, Colorado, 2009.

Jackman MR, Steig AJ, Giles ED, Johnson GC, Higgins JA, Erickson C, Mahan MC, Eckel RH, MacLean PS. Adipose tissue hyperplasia may facilitate the relapse to obesity after long term weight loss. FASEB Summer Research Conference, “The Physiological Basis for Obesity Therapeutics.” Snowmass, Colorado, 2009.

Checkley LA, Rudolph MC, Wellberg EA, Giles ED, Wahdan-Alaswad RS, Houck JA, Edgerton SM, Thor AD, Schedin P, Anderson SM, MacLean PS. Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo . Cancer Prev Res (Phila). 2017 Mar;10(3):198-207. PubMed PMID: 28154203

Sherk VD, Carpenter RD, Giles ED, Higgins JA, Oljira RM, Johnson GC, Mills S, Maclean PS. Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training. Med Sci Sports Exerc. 2017 May;49(5):888-895. PubMed PMID: 28079706

Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2017 Apr;41(4):510-517. PubMed PMID: 27876761

Song ??? Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, Oppelt SA, Kuwabara M, Jensen T, Milagres T, Andres-Hernando A, Ishimoto T, Garcia GE, Johnson G, MacLean PS, Sanchez-Lozada LG, Tolan DR, Johnson RJ. Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice. J Neurophysiol. 2017 Feb 1;117(2):646-654. PubMed PMID: 27852737

Melanson EL, Gozansky WS, Barry DS, MacLean PS, Grunwald GK, Hill JO. Adaptation to high fat diets in lean, obese, and endurance-trained individuals. The Obesity Society, Washington D.C., 2009.

MacLean PS, Giles ED, Johnson GC, McDaniel SM, Fleming-Elder BK, Gilman KA, Andrianakos AG, Jackman AR, Shroyer KR, Schedin PJ. A surprising link between the energetics of weight gain and mammary tumor progression in a model of postmenopausal obesity. Obesity 18(4):696-703, 2010. PMID: 19798068, PMCID in process

Ostendorf DM, Caldwell AE, Creasy SA, Pan Z, Lyden K, Bergouignan A, MacLean PS, Wyatt HR, Hill JO, Melanson EL, Catenacci VA. Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers. Obesity (Silver Spring). 2019 Mar;27(3):496-504. PubMed PMID: 30801984

Civitarese AE, MacLean PS, Carling S, Moro C, Pierce A, Wang Z, Bayless L, Cefalu W, Becker TC, Newgard CB, Walder K, Collier GR, Smith SR, and Ravussin E. Regulation of Skeletal Muscle Oxidative Capacity and Insulin Signaling by the Mitochondrial Protease PARL. Cell Metab 11(5):412-26, 2010. PMID: 20444421, PMCID in process

Ostendorf DM, Melanson EL, Caldwell AE, Creasy SA, Pan Z, MacLean PS, Wyatt HR, Hill JO, Catenacci VA. No consistent evidence of a disproportionately low resting energy expenditure in long-term successful weight-loss maintainers. Am J Clin Nutr. 2018 Oct 1;108(4):658-666. PubMed PMID: 30321282

Jackman JR, MacLean PS, Bessesen DH. Energy expenditure in obesity prone and obesity resistant rats before and after the introduction of a high fat diet. Am J Physiol Regul Integr Comp Physiol 299(4):R1097-105, 2010. PMID: 20686168, PMC2957378

Kuwabara M, Kuwabara R, Niwa K, Hisatome I, Smits G, Roncal-Jimenez CA, MacLean PS, Yracheta JM, Ohno M, Lanaspa MA, Johnson RJ, Jalal DI. Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects. Nutrients. 2018 Aug 3;10(8). PubMed PMID: 30081468

Wellberg EA, Kabos P, Gillen AE, Jacobsen BM, Brechbuhl HM, Johnson SJ, Rudolph MC, Edgerton SM, Thor AD, Anderson SM, Elias A, Zhou XK, Iyengar NM, Morrow M, Falcone DJ, El-Hely O, Dannenberg AJ, Sartorius CA, MacLean PS. FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation. JCI Insight. 2018 Jul 26;3(14). PubMed PMID: 30046001

Giles ED, Jindal S, Wellberg EA, Schedin T, Anderson SM, Thor AD, Edwards DP, MacLean PS, Schedin P. Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast Cancer Res. 2018 Jun 14;20(1):50. PubMed PMID: 29898754

Giles ED, Jackman MR, Johnson GC, Schedin PJ, Houser JL, MacLean PS. Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats. Am J Physiol Regul Integr Comp Physiol 299: R1634-1642, 2010. PMID: 20926768, PMC3007190

Monks J, Orlicky DJ, Stefanski AL, Libby AE, Bales ES, Rudolph MC, Johnson GC, Sherk VD, Jackman MR, Williamson K, Carlson NE, MacLean PS, McManaman JL. Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction. Nutr Diabetes. 2018 Apr 25;8(1):18. PubMed PMID: 29695710

MacLean PS. Comment on: Kaiyala et al. (2010) Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes 59:1657-1666. Diabetes 60: e3; author reply e4, 2011. PMID: 21193727, PMCID in progress

Giles ED, Anderson SM, Schedin PJ, Thor AD, Johnson GC, Hedman KJ, Mahan MC, Houser JL, MacLean PS. Metformin enhances tumor regression and reduces tumor burden in a preclinical paradigm modeling obesity’s impact on postmenopausal breast cancer. American Association for Cancer Research, Washington D.C., 2010.

Wahlig JL, Bales ES, Jackman MR, Johnson GC, MacLean PS, McManaman JL. The effect of high fat diet and obesity on maternal and neonatal lipid metabolism. International Society for Research in Human Milk and Lactation, Lima, Peru, 2010. (dual senior author)

Bergouignan A, Draznin B, Gozansky WS, Barry D, Jackman MR, MacLean PS, Hill JO, Melanson EL. Effect of increasing dietary fat intake on markers of skeletal muscle oxidative capacity in lean and obese adults. The Obesity Society, San Diego, 2010.

Rosenbaum M, Agurs-Collins T, Bray MS, Hall KD, Hopkins M, Laughlin M, MacLean PS, Maruvada P, Savage CR, Small DM, Stoeckel L. Accumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain. Obesity (Silver Spring). 2018 Apr;26 Suppl 2:S25-S34. PubMed PMID: 29575784

MacLean PS, Rothman AJ, Nicastro HL, Czajkowski SM, Agurs-Collins T, Rice EL, Courcoulas AP, Ryan DH, Bessesen DH, Loria CM. The Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) Core Measures Project: Rationale and Approach. Obesity (Silver Spring). 2018 Apr;26 Suppl 2:S6-S15. PubMed PMID: 29575780

Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3138-3143. PubMed PMID: 29507217

Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC. Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight. 2018 Feb 8;3(3). PubMed PMID: 29415895

Foright RM, Presby DM, Sherk VD, Kahn D, Checkley LA, Giles ED, Bergouignan A, Higgins JA, Jackman MR, Hill JO, MacLean PS. Is regular exercise an effective strategy for weight loss maintenance?. Physiol Behav. 2018 May 1;188:86-93. PubMed PMID: 29382563

Rudolph MC, Jackman MR, Presby DM, Houck JA, Webb PG, Johnson GC, Soderborg TK, de la Houssaye BA, Yang IV, Friedman JE, MacLean PS. Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance. Diabetes. 2018 Apr;67(4):651-661. PubMed PMID: 29138256

Giles ED, Wellberg EA, Jackman MR, Johnson GC, Anderson SM, Schedin PJ, Thor AD, MacLean PS. Progesterone receptor and excess energy links obesity to enhanced mammary tumor glucose uptake in a model of menopause. American Institute for Cancer Research, Washington DC, 2010.

Ishimoto T, Garcia ML, Roncal C, Johnson GC, Jackman MR, MacLean PS, Rivard C, Johnson RJ. Fructokinase is an essential factor for developing obesity, fatty liver and insulin resistance induced by high fructose consumption. World Congress of Nephrology Vancouver, Canada, 2011.

Correlates of Successful Maintenance of Weight Loss. Victoria Catenacci, Paul MacLean, Lorri Ogden, Sarit Polsky, Holly Wyatt, and James Hill. The Oxford Handbook of the Social Science of Obesity (Chapter 46). John Cawley, Cornell University, Ithaca, NY, 2011.

MacLean PS. Comment on: Kaiyala et al. (2010) Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes 59:1657-1666. Diabetes 60: e3; author reply e4, 2011. PMID: 21193727, PMCID in progress

Giles ED, Brown IL, MacLean PS, Pan Z, Melanson EL, Heard KJ, Cornier MA, Marden T, Higgins JA. The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults. Nutrients. 2019 Oct 16;11(10). PubMed PMID: 31623184

MacLean PS, Bergouignan A, Cornier M, Jackman MR. Biology’s response to dieting: the impetus for weight regain. Am J Physiol Regul Integr Comp Physiol 301(3):R581-600, 2011.

Presby DM, Checkley LA, Jackman MR, Higgins JA, Jones KL, Giles ED, Houck JA, Webb PG, Steig AJ, Johnson GC, Rudolph MC, MacLean PS. Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. Am J Physiol Regul Integr Comp Physiol. 2019 Nov 1;317(5):R684-R695. PubMed PMID: 31553623

Sherk VD, Jackman MR, Higgins JA, Giles ED, Foright RM, Presby DM, Carpenter RD, Johnson GC, Oljira R, Houck JA, Maclean PS. Impact of Exercise and Activity on Weight Regain and Musculoskeletal Health Post-Ovariectomy. Med Sci Sports Exerc. 2019 Dec;51(12):2465-2473. PubMed PMID: 31274683

Higgins JA, Brown IL, Johnson GC, Jackman MR, Steig A, Wyatt HR, Melanson EL, Hill JO, MacLean PS. Dietary resistant starch attenuates weight regain on a high fat diet and enhances the beneficial effects of regular exercise. Nutri Metabolism 8:49(pg 1-15), 2011.

Grinman DY, Careaga VP, Wellberg EA, Dansey MV, Kordon EC, Anderson SM, Maier MS, Burton G, MacLean PS, Rudolph MC, Pecci A. Liver X receptor-a activation enhances cholesterol secretion in lactating mammary epithelium. Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1136-E1145. PubMed PMID: 30964702

Presby DM, Jackman MR, Rudolph MC, Sherk VD, Foright RM, Houck JA, Johnson GC, Orlicky DJ, Melanson EL, Higgins JA, MacLean PS. Compensation for cold-induced thermogenesis during weight loss maintenance and regain. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E977-E986. PubMed PMID: 30912962

Ostendorf DM, Caldwell AE, Creasy SA, Pan Z, Lyden K, Bergouignan A, MacLean PS, Wyatt HR, Hill JO, Melanson EL, Catenacci VA. Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers. Obesity (Silver Spring). 2019 Mar;27(3):496-504. PubMed PMID: 30801984

Steig AJ, Jackman MR, Giles ED, Higgins JA, Johnson GC, Mahan C, Melanson EL, Wyatt HR, Eckel RH, Hill JO, MacLean PS. Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain. Am J Physiol Regul Integr Comp Physiol 301(3): R656-667, 2011.

Wahlig JL, Bales ES, Jackman MR, Johnson GC, McManaman JL, MacLean PS. Impact of high fat diet and obesity on energy balance and fuel utilization during the metabolic challenge of lactation. Obesity 20(1):65-75, 2012.

Presby DM, Rudolph MC, Sherk VD, Jackman MR, Foright RM, Jones KL, Houck JA, Johnson GC, Higgins JA, Neufer PD, Eckel RH, MacLean PS. Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure. Diabetes. 2021 Feb 3. [Epub ahead of print] PubMed PMID: 33536195

Sherk VD, Heveran CM, Foright RM, Johnson GC, Presby DM, Ferguson VL, MacLean PS. Sex differences in the effect of diet, obesity, and exercise on bone quality and fracture toughness. Bone. 2021 Jan 6;145:115840. [Epub ahead of print] PubMed PMID: 33418101

Bergouignan A, Gozansky WS, Barry DW, Leitner W, MacLean PS, Hill JO, Draznin B, Melanson EL. Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans. PLoS ONE 7(1): e30164, 2012. doi:10.1371/journal.pone.0030164

Andres-Hernando A, Jensen TJ, Kuwabara M, Orlicky DJ, Cicerchi C, Li N, Roncal-Jimenez CA, Garcia GE, Ishimoto T, Maclean PS, Bjornstad P, Sanchez-Lozada LG, Kanbay M, Nakagawa T, Johnson RJ, Lanaspa MA. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. JCI Insight. 2021 Jan 11;6(1). PubMed PMID: 33320834

Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CE, MacLean PS, Jackman MR, Asipu A, Roncal C, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ. Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci (accepted, in press, 2012).

Ishimoto T, Garcia ML, Roncal C, Johnson GC, Jackman MR, MacLean PS, Rivard C, Johnson RJ. Fructokinase is an essential factor for developing obesity, fatty liver and insulin resistance induced by high fructose consumption. World Congress of Nephrology Vancouver, Canada, 2011.

Wellberg EA, Giles ED, Rudolph MC, Schedin PJ, Anderson SM, Thor AD, Edgerton S, MacLean PS. The Progesterone Receptor is Targeted by Metformin in a Rat Model of Post-Menopausal Obesity and is Associated with Tumor Glucose Metabolism. Mammary Gland Gordon Conference, Vermont, 2011.

Giles ED, Wellberg EA, Schedin PJ, Anderson SM, Thor AD, Edgerton S, MacLean PS. Effect of obesity on whole body and tumor specific metabolism: A role for the progesterone receptor in promoting the glycolytic/lipogenic tumor profile. Mammary Gland Gordon Conference, Vermont, 2011.

MacLean PS. Maternal Obesity Impairs Lactation and Produces Offspring with Enhanced Metabolic Efficiency. 11th Annual Ben Franklyn/Lafayette Seminar, Frejus, France, 2011.

Martin Carli JF, Trahan GD, Jones KL, Hirsch N, Rolloff KP, Dunn EZ, Friedman JE, Barbour LA, Hernandez TL, MacLean PS, Monks J, McManaman JL, Rudolph MC. Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology. J Mammary Gland Biol Neoplasia. 2020 Nov 20. [Epub ahead of print] PubMed PMID: 33216249

Foright RM, Johnson GC, Kahn D, Charleston CA, Presby DM, Bouchet CA, Wellberg EA, Sherk VD, Jackman MR, Greenwood BN, MacLean PS. Compensatory eating behaviors in male and female rats in response to exercise training. Am J Physiol Regul Integr Comp Physiol. 2020 Aug 1;319(2):R171-R183. PubMed PMID: 32551825

Nahomi RB, Nam MH, Rankenberg J, Rakete S, Houck JA, Johnson GC, Stankowska DL, Pantcheva MB, MacLean PS, Nagaraj RH. Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice. Int J Mol Sci. 2020 Mar 5;21(5). PubMed PMID: 32151061

Correlates of Successful Maintenance of Weight Loss. Victoria Catenacci, Paul MacLean, Lorri Ogden, Sarit Polsky, Holly Wyatt, and James Hill. The Oxford Handbook of the Social Science of Obesity (Chapter 46). John Cawley, Cornell University, Ithaca, NY, 2011.

Wahlig JL, Bales ES, Jackman MR, Johnson GC, McManaman JL, MacLean PS. Impact of high fat diet and obesity on energy balance and fuel utilization during the metabolic challenge of lactation. Obesity 20(1):65-75, 2012. URL: http://www.ncbi.nlm.nih.gov/pubmed/21720435

Hopp K, Catenacci VA, Dwivedi N, Kline TL, Wang W, You Z, Nguyen DT, Bing K, Poudyal B, Johnson GC, Jackman MR, Miller M, Steele CN, Serkova NJ, MacLean PS, Nemenoff RA, Gitomer B, Chonchol M, Nowak KL. Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease. iScience. 2022 Jan 21;25(1):103697. PubMed PMID: 35059607

Stanislawski MA, Frank DN, Borengasser SJ, Ostendorf DM, Ir D, Jambal P, Bing K, Wayland L, Siebert JC, Bessesen DH, MacLean PS, Melanson EL, Catenacci VA. The Gut Microbiota during a Behavioral Weight Loss Intervention. Nutrients. 2021 Sep 18;13(9). PubMed PMID: 34579125

Bergouignan A, Gozansky WS, Barry DW, Leitner W, MacLean PS, Hill JO, Draznin B, Melanson EL. Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans. PLoS ONE 7(1): e30164, 2012. doi:10.1371/journal.pone.0030164

Dahle JH, Ostendorf DM, Pan Z, MacLean PS, Bessesen DH, Heymsfield SB, Melanson EL, Catenacci VA. Weight and body composition changes affect resting energy expenditure predictive equations during a 12-month weight-loss intervention. Obesity (Silver Spring). 2021 Oct;29(10):1596-1605. PubMed PMID: 34431624

Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CE, MacLean PS, Jackman MR, Asipu A, Roncal C, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ. Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci 13;109(11):4320-5, 2012.

Scalzo RL, Foright RM, Hull SE, Knaub LA, Johnson-Murguia S, Kinanee F, Kaplan J, Houck JA, Johnson G, Sharp RR, Gillen AE, Jones KL, Zhang AMY, Johnson JD, MacLean PS, Reusch JEB, Wright-Hobart S, Wellberg EA. Breast Cancer Endocrine Therapy Promotes Weight Gain With Distinct Adipose Tissue Effects in Lean and Obese Female Mice. Endocrinology. 2021 Nov 1;162(11). PubMed PMID: 34410380

Heitmann BL, Westerterp KR, Loos RJF, Sørensen TIA, O' Dea K, MacLean P, Jensen TK, Eisenmann J, Speakman JR, Simpson SJ, Reed DR, Westerterp-Plantenga MS. Obesity: Lessons from evolution and the environment. Obesity Rev 13(10):910-922, 2012. doi: 10.1111/j.1467-789X.2012.01007.x.

Siebert JC, Stanislawski MA, Zaman A, Ostendorf DM, Konigsberg IR, Jambal P, Ir D, Bing K, Wayland L, Scorsone JJ, Lozupone CA, Görg C, Frank DN, Bessesen D, MacLean PS, Melanson EL, Catenacci VA, Borengasser SJ. Multiomic Predictors of Short-Term Weight Loss and Clinical Outcomes During a Behavioral-Based Weight Loss Intervention. Obesity (Silver Spring). 2021 May;29(5):859-869. PubMed PMID: 33811477

Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs N, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow A, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia 17(2):167-88, 2012. doi: 10.1007/s10911-012-9261-5

Presby DM, Rudolph MC, Sherk VD, Jackman MR, Foright RM, Jones KL, Houck JA, Johnson GC, Higgins JA, Neufer PD, Eckel RH, MacLean PS. Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure. Diabetes. 2021 Apr;70(4):867-877. PubMed PMID: 33536195

Sherk VD, Heveran CM, Foright RM, Johnson GC, Presby DM, Ferguson VL, MacLean PS. Sex differences in the effect of diet, obesity, and exercise on bone quality and fracture toughness. Bone. 2021 Apr;145:115840. PubMed PMID: 33418101

Andres-Hernando A, Jensen TJ, Kuwabara M, Orlicky DJ, Cicerchi C, Li N, Roncal-Jimenez CA, Garcia GE, Ishimoto T, Maclean PS, Bjornstad P, Sanchez-Lozada LG, Kanbay M, Nakagawa T, Johnson RJ, Lanaspa MA. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. JCI Insight. 2021 Jan 11;6(1). PubMed PMID: 33320834

McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, Maclean PS, Majka SM, Klemm DJ, Friedman JE. Attenuated pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. Diabetes 61(10):2495-505, 2012.

Giles ED, Wellberg EA, Astling DP, Anderson SM, Thor AD, Jindal S, Tan AC, Schedin PS, MacLean PS. Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer. Cancer Research 15;72(24):6490-501, 2012. NIHMSID #415411 Publ.ID: CAN-12-1653

Jankowski CM, Gozansky WS, Maclean PS, Shulman B, Wolfe P, Schwartz RS, Kohrt WM. N-Acetyl-4-aminophenol and musculoskeletal adaptations to resistance exercise training. Eur J Appl Physiol (in press, 2012) PMID: 23108581

Varshney R, Das S, Trahan GD, Farriester JW, Mullen GP, Kyere-Davies G, Presby DM, Houck JA, Webb PG, Dzieciatkowska M, Jones KL, Rodeheffer MS, Friedman JE, MacLean PS, Rudolph MC. Neonatal intake of Omega-3 fatty acids enhances lipid oxidation in adipocyte precursors. iScience. 2023 Jan 20;26(1):105750. PubMed PMID: 36590177

Hill EB, Siebert JC, Yazza DN, Ostendorf DM, Bing K, Wayland L, Scorsone JJ, Bessesen DH, MacLean PS, Melanson EL, Catenacci VA, Borengasser SJ. Proteomics, dietary intake, and changes in cardiometabolic health within a behavioral weight-loss intervention: A pilot study. Obesity (Silver Spring). 2022 Nov;30(11):2134-2145. PubMed PMID: 36321274

Jankowski CM, Gozansky WS, Maclean PS, Shulman B, Wolfe P, Schwartz RS, Kohrt WM. N-Acetyl-4-aminophenol and musculoskeletal adaptations to resistance exercise training. Eur J Appl Physiol (in press, 2012) PMID: 23108581

Young BE, Kyere-Davies G, Farriester JW, Varshney R, MacLean PS, Krebs NF, Rudolph MC. Infant Red Blood Cell Arachidonic to Docosahexaenoic Acid Ratio Inversely Associates with Fat-Free Mass Independent of Breastfeeding Exclusivity. Nutrients. 2022 Oct 11;14(20). PubMed PMID: 36296922

Higgins JA, Pan X, MacLean PS, Hagman J. Increased physical activity not decreased energy intake is associated with inpatient medical treatment for Anorexia Nervosa in adolescent females. PLOS ONE (in press, 2013).

McManaman JL, Bales ES, Orlicky DJ, Jackman M, Maclean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS. Perilipin-2 Null Mice are Protected Against Diet-Induced Obesity, Adipose Inflammation and Fatty Liver Disease. J Lipid Res (in press 2013) PMID: 23402988

Wellberg EA, Corleto KA, Checkley LA, Jindal S, Johnson G, Higgins JA, Obeid S, Anderson SM, Thor AD, Schedin PJ, MacLean PS, Giles ED. Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer. Breast Cancer Res. 2022 Jun 20;24(1):42. PubMed PMID: 35725493

Gavin KM, Sullivan TM, Maltzahn JK, Jackman MR, Libby AE, MacLean PS, Kohrt WM, Majka SM, Klemm DJ. Hematopoietic Stem Cell-Derived Adipocytes Modulate Adipose Tissue Cellularity, Leptin Production and Insulin Responsiveness in Female Mice. Front Endocrinol (Lausanne). 2022;13:844877. PubMed PMID: 35721743

Ward AV, Matthews SB, Fettig LM, Riley D, Finlay-Schultz J, Paul KV, Jackman M, Kabos P, MacLean PS, Sartorius CA. Estrogens and Progestins Cooperatively Shift Breast Cancer Cell Metabolism. Cancers (Basel). 2022 Mar 31;14(7). PubMed PMID: 35406548

De Jong NP, Rudolph MC, Jackman MR, Sharp RR, Jones K, Houck J, Pan Z, Reusch JEB, MacLean PS, Bessesen DH, Bergouignan A. Short-Term Adaptations in Skeletal Muscle Mitochondrial Oxidative Capacity and Metabolic Pathways to Breaking up Sedentary Behaviors in Overweight or Obese Adults. Nutrients. 2022 Jan 20;14(3). PubMed PMID: 35276813

Hopp K, Catenacci VA, Dwivedi N, Kline TL, Wang W, You Z, Nguyen DT, Bing K, Poudyal B, Johnson GC, Jackman MR, Miller M, Steele CN, Serkova NJ, MacLean PS, Nemenoff RA, Gitomer B, Chonchol M, Nowak KL. Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease. iScience. 2022 Jan 21;25(1):103697. PubMed PMID: 35059607

Gilley SP, Zarate MA, Zheng L, Jambal P, Yazza DN, Chintapalli SV, MacLean PS, Wright CJ, Rozance PJ, Shankar K. Metabolic and fecal microbial changes in adult fetal growth restricted mice. Pediatr Res. 2023 Nov 7. [Epub ahead of print] PubMed PMID: 37935884

Hill EB, Konigsberg IR, Ir D, Frank DN, Jambal P, Litkowski EM, Lange EM, Lange LA, Ostendorf DM, Scorsone JJ, Wayland L, Bing K, MacLean PS, Melanson EL, Bessesen DH, Catenacci VA, Stanislawski MA, Borengasser SJ. The Microbiome, Epigenome, and Diet in Adults with Obesity during Behavioral Weight Loss. Nutrients. 2023 Aug 16;15(16). PubMed PMID: 37630778

Roberson PA, Kincheloe GN, Welles JE, Xu D, Sam-Clarke M, MacLean PS, Lang CH, Jefferson LS, Kimball SR. Glucose-Induced Activation of mTORC1 is Associated with Hexokinase2 Binding to Sestrins in HEK293T Cells. J Nutr. 2023 Apr;153(4):988-998. PubMed PMID: 37061344

Varshney R, Das S, Trahan GD, Farriester JW, Mullen GP, Kyere-Davies G, Presby DM, Houck JA, Webb PG, Dzieciatkowska M, Jones KL, Rodeheffer MS, Friedman JE, MacLean PS, Rudolph MC. Neonatal intake of Omega-3 fatty acids enhances lipid oxidation in adipocyte precursors. iScience. 2023 Jan 20;26(1):105750. PubMed PMID: 36590177

Castillo-Mancilla JR, Erlandson KM, Hecker ER, Komaie G, Shomaker LB, Cicutto L, Mankin G, Maclean P. Outcomes of a Career Development Award (Pre-K) Mock Review Program for Postdoctoral Fellows and Early-Career Faculty. Acad Med. 2023 Nov 1;98(11):1313-1318. PubMed PMID: 37289813

Professor, Medicine-Endocrinology/Metabolism/Diabetes

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