Our laboratory investigates how viruses interact with the host immune system in the periphery and in the brain. We work to identify these mechanisms and design novel drug therapies or vaccines to treat or prevent viral infections in the nervous system. Our current work has also led us to investigate how inflammation may trigger events related to the development of Parkinson's disease and related neurodegenerative disorders.
Teaching
Professor
(2012)
Graduate School,
Immunology and Microbiology
Virology and Viral Immunology
Professor of Medicine
(2012)
School of Medicine,
Medicine
Professor
(2012)
School of Medicine,
Neurology
CNS infections
Publications
Matthews E, Beckham JD, Piquet AL, Tyler KL, Chauhan L, Pastula DM. Herpesvirus-Associated Encephalitis: an Update. Curr Trop Med Rep. 2022;9(3):92-100. PubMed PMID: 36186545
Pastula DM, Copeland MJ, Hannan MC, Rapaka S, Kitani T, Kleiner E, Showler A, Yuen C, Ferriman EM, House J, O'Brien S, Burakoff A, Gupta B, Money KM, Matthews E, Beckham JD, Chauhan L, Piquet AL, Kumar RN, Tornatore CS, Padgett K, O'Laughlin K, Mangla AT, Kumar PN, Tyler KL, O'Connor SM. Two Cases of Monkeypox-Associated Encephalomyelitis - Colorado and the District of Columbia, July-August 2022. MMWR Morb Mortal Wkly Rep. 2022 Sep 23;71(38):1212-1215. PubMed PMID: 36136957
Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 Jun 6;219(6). PubMed PMID: 35420627
Chauhan L, Pattee J, Ford J, Thomas C, Lesteberg K, Richards E, Bernas CA, Loi M, Dumont L, Annen K, Berg M, Zirbes M, Knight V, Miller A, Jenkins TC, Bennett TD, Monkowski D, Boxer RS, Beckham JD. A Multicenter, Prospective, Observational, Cohort-Controlled Study of Clinical Outcomes Following Coronavirus Disease 2019 (COVID-19) Convalescent Plasma Therapy in Hospitalized Patients With COVID-19. Clin Infect Dis. 2022 Aug 24;75(1):e466-e472. PubMed PMID: 34549274
Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 Apr 19;12(1):6466. PubMed PMID: 35440617
Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022;13:988125. PubMed PMID: 36131937
Iwamoto C, Lesteberg KE, Lamb MM, Calvimontes DM, Guo K, Barrett BS, Mickens KL, Duca LM, Monzon J, Chard AN, Guzman G, Barrios E, Rojop N, Arias K, Gomez M, Paiz C, Bolanos GA, Edwards KM, Zielinski Gutierrez E, Azziz-Baumgartner E, Asturias EJ, Santiago ML, Beckham JD, Olson D. High SARS-CoV-2 Seroprevalence and Rapid Neutralizing Antibody Decline among Agricultural Workers in Rural Guatemala, June 2020-March 2021. Vaccines (Basel). 2022 Jul 21;10(7). PubMed PMID: 35891324
Monogue B, Chen Y, Sparks H, Behbehani R, Chai A, Rajic AJ, Massey A, Kleinschmidt-Demasters BK, Vermeren M, Kunath T, Beckham JD. Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue. Brain. 2022 Oct 21;145(10):3622-3636. PubMed PMID: 35858675
Olson D, Calvimontes DM, Lamb MM, Guzman G, Barrios E, Chacon A, Rojop N, Arias K, Gomez M, Bolanos GA, Monzon J, Chard AN, Iwamoto C, Duca LM, Vuong N, Fineman M, Lesteberg K, Beckham D, Santiago ML, Quicke K, Ebel G, Gutierrez EZ, Azziz-Baumgartner E, Hayden FG, Mansour H, Edwards K, Newman LS, Asturias EJ. Clinical and Economic Impact of COVID-19 on Agricultural Workers, Guatemala(1). Emerg Infect Dis. 2022 Dec;28(13):S277-S287. PubMed PMID: 36502430
Schultz JS, Sparks H, Beckham JD. Arboviral central nervous system infections. Curr Opin Infect Dis. 2021 Jun 1;34(3):264-271. PubMed PMID: 33899755
Chauhan L, Pattee J, Ford J, Thomas C, Lesteberg K, Richards E, Bernas CA, Loi M, Dumont L, Annen K, Berg M, Zirbes M, Knight V, Miller A, Jenkins TC, Bennett TD, Monkowski D, Boxer RS, Beckham JD. A Multi-center, Prospective, Observational-cohort controlled study of Clinical Outcomes following COVID-19 Convalescent plasma therapy in hospitalized COVID-19 patients. Clin Infect Dis. 2021 Sep 21. [Epub ahead of print] PubMed PMID: 34549274
Akiyama BM, Graham ME, O Donoghue Z, Beckham JD, Kieft JS. Three-dimensional structure of a flavivirus dumbbell RNA reveals molecular details of an RNA regulator of replication. Nucleic Acids Res. 2021 Jul 9;49(12):7122-7138. PubMed PMID: 34133732
Brundin P, Nath A, Beckham JD. Is COVID-19 a Perfect Storm for Parkinson's Disease?. Trends Neurosci. 2020 Dec;43(12):931-933. PubMed PMID: 33158605
Lesteberg KE, Fader DS, Beckham JD. Pregnancy Alters Innate and Adaptive Immune Responses to Zika Virus Infection in the Reproductive Tract. J Immunol. 2020 Dec 1;205(11):3107-3121. PubMed PMID: 33127823
Sparks H, Monogue B, Akiyama B, Kieft J, Beckham JD. Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication. Viruses. 2020 Oct 18;12(10). PubMed PMID: 33080971
Kading RC, Brault AC, Beckham JD. Global Perspectives on Arbovirus Outbreaks: A 2020 Snapshot. Trop Med Infect Dis. 2020 Sep 7;5(3). PubMed PMID: 32906771
Melia MT, Paez A, Reid G, Chirch LM, Luther VP, Blackburn BG, Perez F, Abdoler E, Kaul DR, Rehm S, Harik N, Barsoumian A, Person AK, Yun H, Beckham JD, Boruchoff S, Cariello PF, Cutrell JB, Graber CJ, Lee DH, Maziarz E, Paras ML, Razonable RR, Ressner R, Chen A, Chow B, Escota G, Herc E, Johnson A, Maves RC, Nnedu O, Clauss H, Kulkarni P, Pottinger PS, Serpa JA, Bhowmick T, Bittner M, Wooten D, Casanas B, Shnekendorf R, Blumberg EA. The Struggling Infectious Diseases Fellow: Remediation Challenges and Opportunities. Open Forum Infect Dis. 2020 Mar;7(3):ofaa058. PubMed PMID: 32166097
Brundin P, Nath A, Beckham JD. Is COVID-19 a Perfect Storm for Parkinson's Disease?. Trends Neurosci. 2020 Dec;43(12):931-933. PubMed PMID: 33158605
Lesteberg KE, Fader DS, Beckham JD. Pregnancy Alters Innate and Adaptive Immune Responses to Zika Virus Infection in the Reproductive Tract. J Immunol. 2020 Dec 1;205(11):3107-3121. PubMed PMID: 33127823
Sparks H, Monogue B, Akiyama B, Kieft J, Beckham JD. Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication. Viruses. 2020 Oct 18;12(10). PubMed PMID: 33080971
Kading RC, Brault AC, Beckham JD. Global Perspectives on Arbovirus Outbreaks: A 2020 Snapshot. Trop Med Infect Dis. 2020 Sep 7;5(3). PubMed PMID: 32906771
Gill CM, Kapadia RK, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Usutu virus disease: a potential problem for North America?. J Neurovirol. 2020 Apr;26(2):149-154. PubMed PMID: 31858483
Lesteberg KE, Beckham JD. Immunology of West Nile Virus Infection and the Role of Alpha-Synuclein as a Viral Restriction Factor. Viral Immunol. 2019 Jan Feb;32(1):38-47. PubMed PMID: 30222521
Khan M, Beckham JD, Piquet AL, Tyler KL, Pastula DM. An Overview of Powassan Virus Disease. Neurohospitalist. 2019 Oct;9(4):181-182. PubMed PMID: 31534605
Gill CM, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu. Semin Neurol. 2019 Aug;39(4):419-427. PubMed PMID: 31533182
Lesteberg KE, Beckham JD. Immunology of West Nile Virus Infection and the Role of Alpha-Synuclein as a Viral Restriction Factor. Viral Immunol. 2019 Jan Feb;32(1):38-47. PubMed PMID: 30222521
Brown BL, Fidell A, Ingolia G, Murad E, Beckham JD. Infectious causes and outcomes in patients presenting with cerebral spinal fluid pleocytosis. J Neurovirol. 2019 Aug;25(4):448-456. PubMed PMID: 30850974
Gill CM, Kapadia RK, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Usutu virus disease: a potential problem for North America?. J Neurovirol. 2019 Dec 19. [Epub ahead of print] PubMed PMID: 31858483
Brown B, Fidell A, Ingolia G, Murad E, Beckham JD. Defining diagnostic approaches and outcomes in patients with inflammatory CSF: A retrospective cohort study. Clin Neurol Neurosurg. 2018 Sep;172:105-111. PubMed PMID: 29986194
Kashef Hamadani BH, Franco-Paredes C, McCollister B, Shapiro L, Beckham JD, Henao-Martínez AF. Cryptococcosis and cryptococcal meningitis: New predictors and clinical outcomes at a United States academic medical centre. Mycoses. 2018 May;61(5):314-320. PubMed PMID: 29284182
Pastula DM, Durrant JC, Smith DE, Beckham JD, Tyler KL. Zika Virus Disease for the Neurointensivist. Neurocrit Care. 2017 Jun;26(3):457-463. PubMed PMID: 27995511
Grubaugh ND, Massey A, Shives KD, Stenglein MD, Ebel GD, Beckham JD. West Nile Virus Population Structure, Injury, and Interferon-Stimulated Gene Expression in the Brain From a Fatal Case of Encephalitis. Open Forum Infect Dis. 2016 Jan;3(1):ofv182. PubMed PMID: 26730392
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. PubMed PMID: 26799652
Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 Feb 22. [Epub ahead of print] PubMed PMID: 26903031
Pastula DM, Smith DE, Beckham JD, Tyler KL. An Overview of Zika Virus Disease. Neurohospitalist. 2016 Jul;6(3):93-4. PubMed PMID: 27366289
Beckham JD, Pastula DM, Massey A, Tyler KL. Zika Virus as an Emerging Global Pathogen: Neurological Complications of Zika Virus. JAMA Neurol. 2016 Jul 1;73(7):875-9. PubMed PMID: 27183312
Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 Jun;22(3):257-60. PubMed PMID: 26903031
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. PubMed PMID: 26799652
Henao-Martínez AF, Gross L, Mcnair B, McCollister B, DeSanto K, Montoya JG, Shapiro L, Beckham JD. Risk Factors for Cryptococcal Meningitis: A Single United States Center Experience. Mycopathologia. 2016 Dec;181(11-12):807-814. PubMed PMID: 27502502
Massey AR, Beckham JD. Alpha-Synuclein, a Novel Viral Restriction Factor Hiding in Plain Sight. DNA Cell Biol. 2016 Nov;35(11):643-645. PubMed PMID: 27631132
Shives KD, Massey AR, May NA, Morrison TE, Beckham JD. 4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression. Viruses. 2016 Oct 18;8(10). PubMed PMID: 27763553
Beatman EL, Massey A, Shives KD, Burrack KS, Chamanian M, Morrison TE, Beckham JD. Alpha-synuclein expression restricts RNA viral infections in the brain. J Virol. 2015 Dec 30. [Epub ahead of print] PubMed PMID: 26719256
Henao-Martínez AF, Beckham JD. Cryptococcosis in solid organ transplant recipients. Curr Opin Infect Dis. 2015 Aug;28(4):300-7. PubMed PMID: 26098495
Kleinschmidt-DeMasters BK, Beckham JD. West Nile Virus Encephalitis 16 Years Later. Brain Pathol. 2015 Sep;25(5):625-33. PubMed PMID: 26276026
Grubaugh ND, Massey A, Shives KD, Stenglein MD, Ebel GD, Beckham JD. West Nile Virus Population Structure, Injury, and Interferon-Stimulated Gene Expression in the Brain From a Fatal Case of Encephalitis. Open Forum Infect Dis. 2015 Nov 20;3(1):ofv182. PubMed PMID: 26730392
Beatman EL, Massey A, Shives KD, Burrack KS, Chamanian M, Morrison TE, Beckham JD. Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain. J Virol. 2015 Dec 30;90(6):2767-82. PubMed PMID: 26719256
Steele AK, Lee EJ, Manuzak JA, Dillon SM, Beckham JD, McCarter MD, Santiago ML, Wilson CC. Microbial exposure alters HIV-1-induced mucosal CD4 T cell death pathways Ex vivo. Retrovirology. 2014 Feb 4;11:14. PubMed PMID: 24495380
Steele AK, Lee EJ, Manuzak JA, Dillon SM, Beckham JD, McCarter MD, Santiago ML, Wilson CC. Microbial exposure alters HIV-1-induced mucosal CD4 T cell death pathways Ex vivo. Retrovirology. 2014 Feb 4;11:14. PubMed PMID: 24495380
Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol. 2014 Jan;88(2):1080-9. PubMed PMID: 24198425
Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol. 2014 Jan;88(2):1080-9. PubMed PMID: 24198425
Shives KD, Beatman EL, Chamanian M, O'Brien C, Hobson-Peters J, Beckham JD. West nile virus-induced activation of mammalian target of rapamycin complex 1 supports viral growth and viral protein expression. J Virol. 2014 Aug;88(16):9458-71. PubMed PMID: 24920798
Davis LE, Oyer R, Beckham JD, Tyler KL. Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis. JAMA Neurol. 2013 Aug;70(8):1060-4. PubMed PMID: 23732875
Clinical Interests
My clinical interests include general infectious diseases, HIV care and infections of the nervous system. I also participate in a multidisciplinary program with the Department of Neurology in the field of Neurological Infections and Neuroinflammatory diseases.
Care Philosophy
I strive to provide individualized care for each patient that addresses the needs of the underlying disease or infection and also supports the patient and their unique life.
Public Speaking Yes
Have provided lectures to the public on emerging infectious diseases such as Zika virus.
General Information
Medical Schools:
MD, Baylor College of Medicine
(2001)
Undergraduate Schools:
BA, Baylor University (TX)
(1997)
Internships:
Baylor College of Medicine Program
(2002)
Residency Programs:
Baylor College of Medicine Program, Internal Medicine (2004)