David Beckham, MD

Professional Titles

• Professor of Medicine, Infectious Diseases
• Professor of Immunology andd Microbiology

Recognitions

• VA Merit Award, VAMC (2020)
  VA Merit Scholar

Research Interests

Publications

• American Society for Virology Conference: Reovirus activates BMP signaling pathways in vitro and in vivo which contribute to neuronal survival following infection. J. David Beckham, Kathryn D. Tuttle, and Kenneth L. Tyler. July 2009
• Transforming growth factor-beta (TGF-beta) superfamily signaling is activated following viral infection of the central nervous system. J. David Beckham and Kenneth L. Tyler
• Tyler KL and Beckham JD. Management of Acute Shingles. Rev Neurol Dis. 2007. 4(4):203-208.
• Beckham JD and Tyler KL. Developments in the Field of Creutzfeldt-Jakob Disease. Rev Neurol Dis. 2007. 4(3):168-72.
• Goody RJ, Beckham JD, Rubtsova K, Tyler KL. JAK-STAT signaling pathways are activated in the brain following reovirus infection. J. Neurovirol. 2007 Jul;13(4):373-383.
• Beckham JD, Goody R, Clarke P, Bonny C, Tyler KL. A novel strategy for the treatment of viral CNS infection utilizing a cell-permeable inhibitor of c-Jun N-terminal kinase. Journal of Virology. 2007. 81(13): 6984-92
• Davis LE, Beckham JD, Tyler KL. North American encephalitic arboviruses. Neurol Clin. 2008 26:727-57.
• Clarke P, Beckham JD, Goody R, Leser JS, Tyler KL. JNK regulates Fas-mediated apoptosis in vitro and in vivo. Journal of Virology. 2009
• Beckham JD, Tuttle K, Tyler KL. Reovirus activates TGF-? and BMP signaling pathways in the CNS which contribute to neuronal survival following infection. Journal of Virology. 2009
• J. David Beckham and Kenneth L. Tyler. ‘Clinical Manifestations of Neurological Disease’. West Nile Encephalitis Virus Infection: viral pathogenesis and the host immune response. Ed: Micheal Diamond. Springer Publishers. 2008.
• J. David Beckham and Kenneth L. Tyler. ‘Viral Encephalitis.’ Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 7th Ed. Elsevier Churchill Linvingstone. Philadelphia, 2009.
• J. David Beckham and Kenneth L. Tyler. ‘Viral Encephalitis’ Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 7th Ed. Elsevier Churchill Linvingstone. Philadelphia, 2009.
• Beckham JD, Tuttle K, Tyler KL. Reovirus activates TGF-? and BMP signaling pathways in the CNS which contribute to neuronal survival following infection. Journal of Virology. 2009 May; 83(10):5035-45.
• Clarke P, Beckham JD, Goody R, Leser JS, Tyler KL. Fas-mediated apoptotic signaling in the mouse brain following reovirus infection. Journal of Virology. 2009 Jun; 83(12): 6161-70.
• Beckham JD, Tuttle KD, Tyler KL. Caspase-3 activation is required for reovirus-induced encephalitis in vivo. Experimental Neurology. 2010
• Dionne KR, Leser JS, Lerenzen KA, Beckham JD, Tyler KL. A brain slice culture model of viral enceaphlitis reveals an innate CNS cytokine response profile and the terapeutic potential of caspase inhibition. Exp Neurol. 2011Jan 14. (in press, PMID 21241693).
• Beckham JD, Tuttle KD, Tyler KL. Caspase-3 activation is required for Reovirus-induced Encephalitis in vivo. Journal of Neurovirology. 2010 Aug; 16(4):306-17.
• J. David Beckham, Marylou V. Solbrig, and Kenneth L. Tyler. ‘Viral Encephalitis and Meningitis.’ Neurology in Clinical Practice. 6th Ed. Bradley, Daroff, Jankovic, Fenichel. 2011. (in press)
• Ryan Oyer, J. David Beckham, Kenneth L. Tyler. “West Nile virus and St. Louis virus encephalitis”. Handbook of Neurology. Neuroviology. Ed. Tselis and Boos. 2011. (in press)
• Beckham JD and Tyler KL. Neuro-Intensive care of patients with CNS infections. Neurotherapeutics. 2012 Jan; 9(1): 124-138.
• Oyer R, Hedman K, Beatman E, Brault AC, Tyler KL, Beckham JD. ‘West Nile virus activates Autophagy but inhibits formation of autophagolysosomes’. Virology. 2012. (In Revision)
• J. David Beckham, Marylou V. Solbrig, and Kenneth L. Tyler. ‘Infections of the Nervous System.’ Neurology in Clinical Practice. 6th Ed. Bradley, Daroff, Jankovic, Fenichel. Elsevier. 2012.
• Ryan Oyer, J. David Beckham, Kenneth L. Tyler. “West Nile virus and St. Louis virus encephalitis”. Handbook of Neurology. Neuroviology. Ed. Tselis and Boos. 2012.
• Beatman E, Oyer R, Shives KD, Hedman K, Brault AC, Tyler KL, Beckham JD. ‘West Nile replication is Independent of Autophagy activation’. Virology. 2012. 433: 262-272. DOI 10.1016.
• Beckham JD and Tyler KL. Neuro-Intensive care of patients with CNS infections. Neurotherapeutics. 2012 Jan; 9(1): 124-138.
• Davis LE, Oyer R, Beckham JD, KL Tyler. Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis. Archives of Neurology. 2013 (in press)
• Clarke P, Leser JS, Dionne K, Beckham JD, KL Tyler. Extrinsic apoptotic signaling is activated in the brain following infection with West Nile virus and occurs in the absence of infiltrating immune cells. J. Virology. 2013
• J. David Beckham, Marylou V. Solbrig, and Kenneth L. Tyler. ‘Infections of the Nervous System.’ Neurology in Clinical Practice. 6th Ed. Bradley, Daroff, Jankovic, Fenichel. Elsevier. 2012.
• Ryan Oyer, J. David Beckham, Kenneth L. Tyler. “West Nile virus and St. Louis virus encephalitis”. Handbook of Neurology. Neuroviology. Ed. Tselis and Boos. 2012.
• J. David Beckham and Kenneth L. Tyler. “Viral Myelitis”. Infections in the Central Nervous System. 4th Ed. Scheld, Whitley, Marra. 2013. (in press)
• Davis LE, Oyer R, Beckham JD, Tyler KL. Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis. JAMA Neurol. 2013 Aug;70(8):1060-4. PubMed PMID: 23732875
• Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol. 2014 Jan;88(2):1080-9. PubMed PMID: 24198425
• Steele AK, Lee EJ, Manuzak JA, Dillon SM, Beckham JD, McCarter MD, Santiago ML, Wilson CC. Microbial exposure alters HIV-1-induced mucosal CD4 T cell death pathways Ex vivo. Retrovirology. 2014 Feb 4;11:14. PubMed PMID: 24495380
• Shives K, Beatman E, Beckham JD. West Nile virus activates mTOR signaling in support of viral protein expression. Journal of Virology. 2014
• Ryan Oyer, J. David Beckham, Kenneth L. Tyler. West Nile virus and St. Louis virus encephalitis. Handbook of Clinical Neurology. Neurovirology, Vol. 123. Ed Tselis and Booss. Elsevier B.V. 2014.
• J. David Beckham and Kenneth Tyler. Viral Myelitis. Infections of the Central Nervous System. 4th ed. Schooled, Whitley, Marra. 2014.
• Shives KD, Beatman EL, Chamanian M, O'Brien C, Hobson-Peters J, Beckham JD. West nile virus-induced activation of mammalian target of rapamycin complex 1 supports viral growth and viral protein expression. J Virol. 2014 Aug;88(16):9458-71. PubMed PMID: 24920798
• Beatman EL, Massey A, Shives KD, Burrack KS, Chamanian M, Morrison TE, Beckham JD. Alpha-synuclein expression restricts RNA viral infections in the brain. J Virol. 2015 Dec 30. [Epub ahead of print] PubMed PMID: 26719256
• Henao-Martínez AF, Beckham JD. Cryptococcosis in solid organ transplant recipients. Curr Opin Infect Dis. 2015 Aug;28(4):300-7. PubMed PMID: 26098495
• Kleinschmidt-DeMasters BK, Beckham JD. West Nile Virus Encephalitis 16 Years Later. Brain Pathol. 2015 Sep;25(5):625-33. PubMed PMID: 26276026
• Grubaugh ND, Massey A, Shives KD, Stenglein MD, Ebel GD, Beckham JD. West Nile Virus Population Structure, Injury, and Interferon-Stimulated Gene Expression in the Brain From a Fatal Case of Encephalitis. Open Forum Infect Dis. 2016 Jan;3(1):ofv182. PubMed PMID: 26730392
• Beckham JD, Tyler KL. Arbovirus Infections. Continuum (Minneap Minn). 2015 Dec;21(6 Neuroinfectious Disease):1599-611. PubMed PMID: 26633778
• Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. PubMed PMID: 26799652
• Steele AK, Lee EJ, Manuzak JA, Dillon SM, Beckham JD, McCarter MD, Santiago ML, Wilson CC. Microbial exposure alters HIV-1-induced mucosal CD4 T cell death pathways Ex vivo. Retrovirology. 2014 Feb 4;11:14. PubMed PMID: 24495380
• Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 Feb 22. [Epub ahead of print] PubMed PMID: 26903031
• Beckham JD, Pastula DM, Massey A, Tyler KL. Zika virus, an emerging global pathogen. JAMA Neurology. 2016 March. (In press)
• Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol. 2014 Jan;88(2):1080-9. PubMed PMID: 24198425
• Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS. Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease. Science. 2016 Dec 2;354(6316):1148-1152. PubMed PMID: 27934765
• McGuinness I, Beckham JD, Tyler KL, Pastula DM. An Overview of Yellow Fever Virus Disease. Neurohospitalist. 2017 Oct;7(4):157-158. PubMed PMID: 28974992
• Shives KD, Massey AR, May NA, Morrison TE, Beckham JD. 4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression. Viruses. 2016 Oct 18;8(10). PubMed PMID: 27763553
• Beckham JD. Zika virus, a novel mosquito-borne congenital virus infection. J Neurovirol. 2017 Jun;23(3):339-340. PubMed PMID: 28429288
• Massey AR, Beckham JD. Alpha-Synuclein, a Novel Viral Restriction Factor Hiding in Plain Sight. DNA Cell Biol. 2016 Nov;35(11):643-645. PubMed PMID: 27631132
• Henao-Martínez AF, Gross L, Mcnair B, McCollister B, DeSanto K, Montoya JG, Shapiro L, Beckham JD. Risk Factors for Cryptococcal Meningitis: A Single United States Center Experience. Mycopathologia. 2016 Dec;181(11-12):807-814. PubMed PMID: 27502502
• Shives KD, Tyler KL, Beckham JD. Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis. J Neuroimmunol. 2017 Jul 15;308:102-111. PubMed PMID: 28291542
• Pastula DM, Smith DE, Beckham JD, Tyler KL. An Overview of Zika Virus Disease. Neurohospitalist. 2016 Jul;6(3):93-4. PubMed PMID: 27366289
• Beckham JD, Pastula DM, Massey A, Tyler KL. Zika Virus as an Emerging Global Pathogen: Neurological Complications of Zika Virus. JAMA Neurol. 2016 Jul 1;73(7):875-9. PubMed PMID: 27183312
• Duca LM, Beckham JD, Tyler KL, Pastula DM. Zika Virus Disease and Associated Neurologic Complications. Curr Infect Dis Rep. 2017 Jan;19(1):4. PubMed PMID: 28220392
• Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 Jun;22(3):257-60. PubMed PMID: 26903031
• Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. PubMed PMID: 26799652
• Grubaugh ND, Massey A, Shives KD, Stenglein MD, Ebel GD, Beckham JD. West Nile Virus Population Structure, Injury, and Interferon-Stimulated Gene Expression in the Brain From a Fatal Case of Encephalitis. Open Forum Infect Dis. 2015 Nov 20;3(1):ofv182. PubMed PMID: 26730392
• Beatman EL, Massey A, Shives KD, Burrack KS, Chamanian M, Morrison TE, Beckham JD. Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain. J Virol. 2015 Dec 30;90(6):2767-82. PubMed PMID: 26719256
• Beckham JD, Tyler KL. Arbovirus Infections. Continuum (Minneap Minn). 2015 Dec;21(6 Neuroinfectious Disease):1599-611. PubMed PMID: 26633778
• Pastula DM, Durrant JC, Smith DE, Beckham JD, Tyler KL. Zika Virus Disease for the Neurointensivist. Neurocrit Care. 2017 Jun;26(3):457-463. PubMed PMID: 27995511
• Asturias E, Beckham JD. Arbovirus Dermatology. Fitzpatrick’s Dermatology. 2018. (In press)
• J. David Beckham and Kenneth L. Tyler. ‘Viral Encephalitis’ Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th Ed. Elsevier Churchill Livingstone. Philadelphia, 2009. Revised 2013, Revised 2018
• Brown B, Fidell A, Ingolia G, Murad E, Beckham JD. Defining etiologies and outcomes of patients presenting with neuroinflammation. Neurology: Clinical Practice. 2018. (in press)
• Lesteberg KE, Beckham JD. Immunology of West Nile Virus Infection and the Role of Alpha-Synuclein as a Viral Restriction Factor. Viral Immunol. 2019 Jan Feb;32(1):38-47. PubMed PMID: 30222521
• Gill CM, Kapadia RK, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Usutu virus disease: a potential problem for North America?. J Neurovirol. 2019 Dec 19. [Epub ahead of print] PubMed PMID: 31858483
• Khan M, Beckham JD, Piquet AL, Tyler KL, Pastula DM. An Overview of Powassan Virus Disease. Neurohospitalist. 2019 Oct;9(4):181-182. PubMed PMID: 31534605
• Brown B, Fidell A, Ingolia G, Murad E, Beckham JD. Defining diagnostic approaches and outcomes in patients with inflammatory CSF: A retrospective cohort study. Clin Neurol Neurosurg. 2018 Sep;172:105-111. PubMed PMID: 29986194
• Gill CM, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu. Semin Neurol. 2019 Aug;39(4):419-427. PubMed PMID: 31533182
• Brown BL, Fidell A, Ingolia G, Murad E, Beckham JD. Infectious causes and outcomes in patients presenting with cerebral spinal fluid pleocytosis. J Neurovirol. 2019 Aug;25(4):448-456. PubMed PMID: 30850974
• Kashef Hamadani BH, Franco-Paredes C, McCollister B, Shapiro L, Beckham JD, Henao-Martínez AF. Cryptococcosis and cryptococcal meningitis: New predictors and clinical outcomes at a United States academic medical centre. Mycoses. 2018 May;61(5):314-320. PubMed PMID: 29284182
• Kleinschmidt-DeMasters BK, Beckham JD, Tyler KL. Infections and Inflammatory Disorders. Practical Surgical Neuropathology. 2018.
• Asturias E, Beckham JD. Arbovirus Dermatology. Fitzpatrick's Dermatology. 2018.
• Lesteberg KE, Beckham JD. Immunology of West Nile Virus Infection and the Role of Alpha-Synuclein as a Viral Restriction Factor. Viral Immunol. 2019 Jan Feb;32(1):38-47. PubMed PMID: 30222521
• Brundin P, Nath A, Beckham JD. Is COVID-19 a Perfect Storm for Parkinson's Disease?. Trends Neurosci. 2020 Dec;43(12):931-933. PubMed PMID: 33158605
• Lesteberg KE, Fader DS, Beckham JD. Pregnancy Alters Innate and Adaptive Immune Responses to Zika Virus Infection in the Reproductive Tract. J Immunol. 2020 Dec 1;205(11):3107-3121. PubMed PMID: 33127823
• Sparks H, Monogue B, Akiyama B, Kieft J, Beckham JD. Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication. Viruses. 2020 Oct 18;12(10). PubMed PMID: 33080971
• Kading RC, Brault AC, Beckham JD. Global Perspectives on Arbovirus Outbreaks: A 2020 Snapshot. Trop Med Infect Dis. 2020 Sep 7;5(3). PubMed PMID: 32906771
• Melia MT, Paez A, Reid G, Chirch LM, Luther VP, Blackburn BG, Perez F, Abdoler E, Kaul DR, Rehm S, Harik N, Barsoumian A, Person AK, Yun H, Beckham JD, Boruchoff S, Cariello PF, Cutrell JB, Graber CJ, Lee DH, Maziarz E, Paras ML, Razonable RR, Ressner R, Chen A, Chow B, Escota G, Herc E, Johnson A, Maves RC, Nnedu O, Clauss H, Kulkarni P, Pottinger PS, Serpa JA, Bhowmick T, Bittner M, Wooten D, Casanas B, Shnekendorf R, Blumberg EA. The Struggling Infectious Diseases Fellow: Remediation Challenges and Opportunities. Open Forum Infect Dis. 2020 Mar;7(3):ofaa058. PubMed PMID: 32166097
• Gill CM, Kapadia RK, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Usutu virus disease: a potential problem for North America?. J Neurovirol. 2020 Apr;26(2):149-154. PubMed PMID: 31858483
• Chauhan L, Pattee J, Ford J, Thomas C, Lesteberg K, Richards E, Bernas CA, Loi M, Dumont L, Annen K, Berg M, Zirbes M, Knight V, Miller A, Jenkins TC, Bennett TD, Monkowski D, Boxer RS, Beckham JD. A Multi-center, Prospective, Observational-cohort controlled study of Clinical Outcomes following COVID-19 Convalescent plasma therapy in hospitalized COVID-19 patients. Clin Infect Dis. 2021 Sep 21. [Epub ahead of print] PubMed PMID: 34549274
• Akiyama BM, Graham ME, O Donoghue Z, Beckham JD, Kieft JS. Three-dimensional structure of a flavivirus dumbbell RNA reveals molecular details of an RNA regulator of replication. Nucleic Acids Res. 2021 Jul 9;49(12):7122-7138. PubMed PMID: 34133732
• Schultz JS, Sparks H, Beckham JD. Arboviral central nervous system infections. Curr Opin Infect Dis. 2021 Jun 1;34(3):264-271. PubMed PMID: 33899755
• Brundin P, Nath A, Beckham JD. Is COVID-19 a Perfect Storm for Parkinson's Disease?. Trends Neurosci. 2020 Dec;43(12):931-933. PubMed PMID: 33158605
• Lesteberg KE, Fader DS, Beckham JD. Pregnancy Alters Innate and Adaptive Immune Responses to Zika Virus Infection in the Reproductive Tract. J Immunol. 2020 Dec 1;205(11):3107-3121. PubMed PMID: 33127823
• Sparks H, Monogue B, Akiyama B, Kieft J, Beckham JD. Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication. Viruses. 2020 Oct 18;12(10). PubMed PMID: 33080971
• Kading RC, Brault AC, Beckham JD. Global Perspectives on Arbovirus Outbreaks: A 2020 Snapshot. Trop Med Infect Dis. 2020 Sep 7;5(3). PubMed PMID: 32906771
• Matthews E, Beckham JD, Piquet AL, Tyler KL, Chauhan L, Pastula DM. Herpesvirus-Associated Encephalitis: an Update. Curr Trop Med Rep. 2022;9(3):92-100. PubMed PMID: 36186545
• Krett JD, Beckham JD, Tyler KL, Piquet AL, Chauhan L, Wallace CJ, Pastula DM, Kapadia RK. Neurology of Acute Viral Infections. Neurohospitalist. 2022 Oct;12(4):632-646. PubMed PMID: 36147750
• Pastula DM, Copeland MJ, Hannan MC, Rapaka S, Kitani T, Kleiner E, Showler A, Yuen C, Ferriman EM, House J, O'Brien S, Burakoff A, Gupta B, Money KM, Matthews E, Beckham JD, Chauhan L, Piquet AL, Kumar RN, Tornatore CS, Padgett K, O'Laughlin K, Mangla AT, Kumar PN, Tyler KL, O'Connor SM. Two Cases of Monkeypox-Associated Encephalomyelitis - Colorado and the District of Columbia, July-August 2022. MMWR Morb Mortal Wkly Rep. 2022 Sep 23;71(38):1212-1215. PubMed PMID: 36136957
• Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022;13:988125. PubMed PMID: 36131937
• Iwamoto C, Lesteberg KE, Lamb MM, Calvimontes DM, Guo K, Barrett BS, Mickens KL, Duca LM, Monzon J, Chard AN, Guzman G, Barrios E, Rojop N, Arias K, Gomez M, Paiz C, Bolanos GA, Edwards KM, Zielinski Gutierrez E, Azziz-Baumgartner E, Asturias EJ, Santiago ML, Beckham JD, Olson D. High SARS-CoV-2 Seroprevalence and Rapid Neutralizing Antibody Decline among Agricultural Workers in Rural Guatemala, June 2020-March 2021. Vaccines (Basel). 2022 Jul 21;10(7). PubMed PMID: 35891324
• Monogue B, Chen Y, Sparks H, Behbehani R, Chai A, Rajic AJ, Massey A, Kleinschmidt-Demasters BK, Vermeren M, Kunath T, Beckham JD. Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue. Brain. 2022 Oct 21;145(10):3622-3636. PubMed PMID: 35858675
• Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 Jun 6;219(6). PubMed PMID: 35420627
• Chauhan L, Pattee J, Ford J, Thomas C, Lesteberg K, Richards E, Bernas CA, Loi M, Dumont L, Annen K, Berg M, Zirbes M, Knight V, Miller A, Jenkins TC, Bennett TD, Monkowski D, Boxer RS, Beckham JD. A Multicenter, Prospective, Observational, Cohort-Controlled Study of Clinical Outcomes Following Coronavirus Disease 2019 (COVID-19) Convalescent Plasma Therapy in Hospitalized Patients With COVID-19. Clin Infect Dis. 2022 Aug 24;75(1):e466-e472. PubMed PMID: 34549274
• Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 Apr 19;12(1):6466. PubMed PMID: 35440617
• Olson D, Calvimontes DM, Lamb MM, Guzman G, Barrios E, Chacon A, Rojop N, Arias K, Gomez M, Bolanos GA, Monzon J, Chard AN, Iwamoto C, Duca LM, Vuong N, Fineman M, Lesteberg K, Beckham D, Santiago ML, Quicke K, Ebel G, Gutierrez EZ, Azziz-Baumgartner E, Hayden FG, Mansour H, Edwards K, Newman LS, Asturias EJ. Clinical and Economic Impact of COVID-19 on Agricultural Workers, Guatemala(1). Emerg Infect Dis. 2022 Dec;28(13):S277-S287. PubMed PMID: 36502430

Professional Memberships

• American College of Physicians (ACP), Fellow
• American Society for Virology (ASV), Member
• Infectious Disease Society of America (IDSA), Fellow
• American Society for Microbiology (ASM), Member
• American Association for the Advancement of Science, Member

Practice Locations

• University of Colorado Hospital
• Veterans Affairs Medical Center

• Center for Neuroscience
• Colorado Clinical & Translational Sciences Institute (CCTSI)
• University of Colorado Movement Disorders Center
• University of Colorado Cancer Center

Specialty Information

• Infectious Disease, Board Certification (2007, 2016)
• Internal Medicine, Board Certification (2004, 2014)

• Infections
• Brain and Nervous System - Brain Abscess
• Brain and Nervous System - Meningitis
• Immune System - AIDS
• Immune System - AIDS / HIV Disease
• Infections - Viral Infections
• Infections - Pneumonia
• Infections - Influenza
• Infections - Fungal Infections
• Infections - Bacterial Infections
• Brain and Nervous System
• Immune System