Ellen Burnham, MD

Professional Titles

• Director, Colorado Clinical and Translational Sciences Institute K12 Program
• Co-PI, Colorado T32 Training Program in Pulmonary Disease

Recognitions

• Faculty Innovator Award, University of Colorado School of Medicine, Department of Medicine (2020)
• Medical Staff Partners in Care Award, University of Colorado Hospital (2021)
• Excellence in Research Award, University of Colorado School of Medicine, Department of Medicine (2024)

Research Interests

I am a pulmonary and critical care physician-scientist. Our group's research focuses on the effect of alcohol and substance use on development of pneumonia and ARDS, and outcomes among these patients. Along with local and national collaborators, we have formed a consortium to enable translational investigations in this area, and have developed a biorepository to facilitate investigations. I am also committed to training and career development of post-doctoral fellows and junior faculty seeking careers in academic medicine. I am the Program Director for the CCTSI's K12 Mentored Career Development program that supports training of junior faculty conducting translational research, and am a Co-PI for the Colorado T32 Training Program in Pulmonary Diseases that supports post-doctoral fellows at the University of Colorado.

Publications

• Burnham EL, Moss M. Progenitor cells in acute lung injury. Minerva Anesthesiol 2006;72:369-374.
• Esper A, Burnham EL, Moss M. The effect of alcohol abuse on ARDS and multiple organ dysfunction. Minerva Anesthesiol 2006;72:375-381.
• Khan J, Burnham EL, Moss M. Acquired weakness in the ICU: Critical Illness Myopathy and Neuropathy. Minerva Anesthesiol 2006;72:
• Moss M, Burnham EL. Treatment of alcohol abuse in critical illness. Lancet 2006;368:2231-2242.
• Burnham EL, Moss M, Ritzenthaler JD, Roman JR. Fibronectin transcription is upregulated in the lung of subjects with chronic alcohol abuse. (Alcohol Clin Exp Res, available on-line).
• Burnham EL. The role of stem cells in repair of acute lung injury. (J of Stem Cells, accepted).
• Burnham EL, Moss M. The Acute Respiratory Distress Syndrome. Critical Care Secrets, Eds. P. Parsons, J Heffner, 2006.
• Burnham EL, Taylor WR, Sutcliffe D, Moss M. Peripheral blood mononuclear cells in ALI: a function in endothelial repair? Proc Am Thor Soc 2007 (in press for meeting, May 2007)
• Yeh M, Burnham E, Moss M, Brown LA. Cysteine in the Epithelial Lining Fluid – A Potential Prognostic Indicator of ARDS Outcome. Proc Am Thor Soc 2007 (in press for meeting, May 2007)
• Burnham EL. The role of stem cells in repair of acute lung injury. J Stem Cells 2007; vol 2, issue 2, chapter 5. Koka P, ed.
• Yeh MY, Burnham EL, Moss M, Brown LAS. Cysteine in the epithelial lining fluid—a potential prognostic indicator of ARDS outcome. Am J Respir Crit Care Med 2007;175: A757.
• Burnham EL, Taylor WR, Sutcliffe D, Moss M. Peripheral blood mononuclear cells in ALI: a function in endothelial repair? Am J Respir Crit Care Med 2007;175:A899.
• De Wit M, Best AM, Gennings C, Burnham EL, Moss M. Alcohol use disorders increase the risk for mechanical ventilation in medical patients. Alc Clin Exp Res 2007;31:1224-1230.
• Yeh MY, Burnham EL, Moss M, and Brown LAS. Chronic Alcoholism Alters Systemic and Pulmonary Glutathione Redox Status. Am J Respir Crit Care Med 2007;270:270-276.
• Yeh MY, Burnham EL, Moss M, and Brown LAS. Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics. Respir Med. Epub 2007 Oct 30
• Martin J, Helm K, Ruegg P, Garcia M, Burnham E, and Majka S. The mesenchymal stem cell potential of the adult lung side population. Cytotherapy, epub February 2008.
• Burnham EL. Circulating progenitor cells: a novel therapy for acute respiratory distress syndrome? (editorial view). Anesthesiol 2008:108(3):354-356.
• Yeh MY, Burnham EL, Moss M, Brown LA. Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics. Respir Med. 2008 Feb;102(2):248-55.
• Burnham EL. Circulating progenitors in lung injury: a novel therapy for acute respiratory distress syndrome? Anesthesiology. 2008 Mar;108(3):354-6.
• Martin J, Helm K, Ruegg P, Varella-Garcia M, Burnham E, Majka S.Adult lung side population cells have mesenchymal stem cell potential. Cytotherapy. 2008;10(2):140-51.
• Burnham EL, Halkar R, Burks M, Moss M.The effects of alcohol abuse on pulmonary alveolar-capillary barrier function in humans. Alcohol Alcohol. 2009 Jan-Feb;44(1):8-12.
• de Wit M, Gennings C, Zilberberg M, Burnham EL, Moss M, Balster RL. Drug withdrawal, cocaine and sedative use disorders increase the need for mechanical ventilation in medical patients. Addiction. 2008 Sep;103(9):1500-8.
• Burnham EL. Identification of risky alcohol consumption in the preoperative assessment: opportunity to diagnose and intervene. Anesthesiology. 2008 Aug;109(2):169-70.
• Majka SM, Skokan M, Wheeler L, Harral J, Gladson S, Burnham E, Loyd JE, Stenmark KR, Varella-Garcia M, West J. Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L1028-39.
• Graham BB, Burnham EL, Janssen JS, Janssen WJ. Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter. Chest. 2008 Nov;134(5):1074-9.
• Burnham EL, Edwards M, Sutcliffe D, Taylor WR, and Moss M. Endothelial progenitor cells are decreased in the circulation of patients with sepsis. Experimental Biology, abstract 133, San Diego, CA, April 2008
• De Wit M, Gennings C, Zilberberg M, Burnham EL, Moss M, Balster R. Impact of drug use disorders on risk for mechanical ventilation in medical patients. Am J Respir Crit Care Med 2008;177: A127
• Burnham EL, Edwards M, Sutcliffe D, Taylor WR, Moss M. Variability in circulating progenitor cells between patients with acute lung injury and severe sepsis: impact of a pulmonary etiology. Am J Respir Crit Care Med 2008;177: A233.
• Prevalence of post-traumatic stress disorder in conjunction with the burnout syndrome in intensive care unit nurses.
• Burnham EL, Halkar R, Burks M, Moss M. The Effects of Alcohol Abuse on Pulmonary Alveolar-Capillary Barrier Function in Humans. Alcohol Alcohol. 2009;44(1):8-12.
• Burnham EL, Gaydos J, Mealer M, Majka S, Moss M. Acute Lung Injury but not Sepsis is Associated with Increased Colony Formation by Peripheral Blood Mononuclear Cells. Am J Respir Cell Mol Biol 2009, accepted.
• Mealer M, Burnham EL, Rothbaum B, and Moss M. The prevalence and impact of post traumatic stress disorder and burnout syndrome in nurses. Depress Anxiety. 2009 Nov 14;26(12):1118-1126.
• Burnham EL, Majka S, Moss M. Role of Progenitor Cells in Lung Disease Prognosis. For Stem Cells and the Respiratory System, May 2009, M Rojas, Ed, in press.
• Boé DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, Moss M, Vandivier RW. Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alc Clin Exp Res 2010; 34: 1723-32.
• Burnham EL, Gaydos J, Hess E, House R, Cooper J. Alcohol use disorders affect antimicrobial proteins and anti-pneumococcal activity in epithelial lining fluid obtained via bronchoalveolar lavage. Alcohol Alcohol 2010; 45:414-21.
• Burnham EL, Gaydos J, Phang TL, Vandivier RW, House R. Alveolar Macrophage Gene Expression is altered in the Setting of Alcohol Use Disorders. Alc Clin Exp Res 2011: 35(2):284-94. **Denoted as an article of special interest by the editor
• Burnham EL, Majka S, Moss M. Role of Progenitor Cells in Lung Disease Prognosis. For Stem Cells and the Respiratory System, May 2010, M Rojas, Ed.
• Burnham EL, Moss M, Geraci MW. The case for 24/7 in-house intensivist coverage. Am J Respir Crit Care Med 2010; 2010;181(11):1159-60.
• Brown SD, Burnham E, and Brown LAS. The Effects of Alcohol Abuse on Cytokine Expression In Bronchoalveolar Fluid
• Brown SD, Burnham E, and Brown LAS. A Shift Toward A More Alternatively Activated Human Alveolar Macrophage: A Response To Chronic Alcohol Ingestion
• Baker TA, Davis CS, Bach HH, Romero J, Burnham EL, Kovacs EJ, Gamelli RL, Majetschak M. Ubiquitin in bronchoalveolar lavage fluid after burn and inhalation injury.
• Davis CS, Ramirez L, Burnham EL, Kovacs EJ. Alcohol modifies the baseline pulmonary immune profile in humans.
• Burnham EL, Fleming M. Selection of research mentors for K funded scholars. Clin Transl Sci 2011;4: 87-92.
• Burnham EL, Schiro S, Fleming M. Mentoring K Scholars: Strategies to support research mentors. Clin Trans Sci, 2011;4:199-203.
• Majka SM, Burnham EL, Stenmark KR (editorial). Cell based therapies in pulmonary hypertension: who, what, and when? Am J Physiol Lung Cell Mol Physiol 2011; 301(1):L9-L11.
• Baker TA, Davis CS, Bach HH, Romero J, Burnham EL, Kovacs EJ, Gamelli RL, Majetschak M. Ubiquitin and stromal cell-derived factor-1a in bronchoalveolar lavage fluid after burn and inhalation injury. J Burn Care Res 2012; 33: 57-64.
• Malcolm KC, Kret JE, Young RL, Poch KR, Caceres SM, Douglas IS, Coldren CD, Burnham EL, Moss M, Nick JA. Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome. PLoS One 2011;6(7):e21958
• Paine R III, Standiford TJ, Dechert RE, Moss M, Martin GS, Rosenberg AL, Thannickal VJ, Burnham EL, Brown MB, Hyzy RC. A randomized trial of recombinant human GM-CSF for patients with acute lung injury. Crit Care Med 2012; 40(1):90-7
• Clark B, Smart A, House R, Douglas I, Burnham E, Moss M. Severity of Acute Illness is Associated with Baseline Readiness to Change in Medical Intensive Care Unit Patients with Unhealthy Alcohol Use. Alc Clin Exp Res 2011, Sept 26, in press
• Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illness. Crit Care 2011 Sep 29;15(5):R231
• Fisichella PM, Davis CS, Lundberg PW, Lowery E, Burnham EL, Alex CG, Ramirez L, Pelletiere K, Love RB, Kuo PC, Kovacs EJ. The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery 2011 Oct;150(4):598-606.
• Albright JM, Davis CS, Bird MD, Ramirez L, Kim H, Burnham EL, Gamelli RL, Kovacs EJ. The acute pulmonary inflammatory response to the graded severity of smoke inhalation injury. Crit Care Med 2011 Nov 3, in press.
• Baker TA, Davis CS, Bach HH 4th, Romero J, Burnham EL, Kovacs EJ, Gamelli RL, Majetschak M. Ubiquitin and stromal cell-derived factor-1a in bronchoalveolar lavage fluid after burn and inhalation injury. J Burn Care Res 2012;33(1):57-64.
• Burnham EL, McCord JM, Bose S, Brown LA, House R, Moss M, Gaydos J. Protandim(R) does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders. Am J Physiol Lung Cell Mol Physiol 2012 Jan 20.
• Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial.National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Rice TW, Wheeler AP, Thompson BT, Steingrub J, Hite RD, Moss M, Morris A, Dong N, Rock P. JAMA. 2012 Feb 22;307(8):795-803. **i was a contributing author.
• Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation.Finigan JH, Mishra R, Vasu VT, Silveira LJ, Nethery DE, Standiford TJ, Burnham EL, Moss M, Kern JA. Eur Respir J. 2013 Feb;41(2):396-401.
• Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia.Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM. Chest. 2012 Dec;142(6):1569-76.
• Diagnosis and treatment of post-extubation dysphagia: results from a national survey.Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. J Crit Care. 2012 Dec;27(6):578-86.
• Michael Fleming, MD, MPH; Ellen L. Burnham, MD, MS; W. Charles Huskins, MD, MSc JAMA. 2012;308(19):1981-1982.
• Chest CT Features are Associated With Poorer Quality of Life in Acute Lung Injury Survivors* Burnham EL, Hyzy RC, Paine R 3rd, Coley C 2nd, Kelly AM, Quint LE, Lynch D, Janssen WJ, Moss M, Standiford TJ. Crit Care Med. 2013 Feb;41(2):445-456.
• The epidemiology of Acute Respiratory Distress Syndrome Clark BJ, Burnham EL to be published in textbook "The Alcoholic Lung" by Springer David Guidot, MD, and Ashish Mehta, MD editors
• Alcohol screening scores and 90 day outcomes in patients with acute lung injury Clark BJ, Williams A, Cecere LM, Bradley KA, Macht M, Moss M and Burnham EL on behalf of the ARDS network investigators accepted for publication in Critical Care Medicine
• The fibroproliferative response in ARDS: Ode to the Forgotten Lung Burnham EL, Janssen WJ, Riches DWH, Moss M and Downey GP. accepted for publication in the European Respiratory Journal
• Tanaka T, Doe JM, Horstmann SA, Ahmad S, Ahmad A, Min SJ, Reynolds PR, Suram S, Gaydos J, Burnham EL, Vandivier RW. Neuroendocrine Signaling via the Serotonin Transporter Regulates Clearance of Apoptotic Cells. J Biol Chem. 2014 Feb 25. [Epub ahead of print] PubMed PMID: 24570000
• Burnham EL. 24/7 attendings: "helicoptering" the housestaff?. Pediatrics. 2014 Jan;133(1):131-3. PubMed PMID: 24323999
• Burnham EL, Hyzy RC, Paine R 3rd, Kelly AM, Quint LE, Lynch D, Curran-Everett D, Moss M, Standiford TJ. Detection of fibroproliferation by chest high-resolution CT scan in resolving ARDS. Chest. 2014 Nov;146(5):1196-204. PubMed PMID: 24722949
• Smart A, Thompson BT, Needham DM, Hopkins RO, Williams A, Burnham EL, Moss M, NHLBI ARDS Network Investigators. Surrogate consent for genetic testing, the reconsent process, and consent for long-term outcomes in acute respiratory distress syndrome trials. Am J Respir Crit Care Med. 2013 Dec 1;188(11):1370-3. PubMed PMID: 24289781
• Pfund C, House SC, Asquith P, Fleming MF, Buhr KA, Burnham EL, Eichenberger Gilmore JM, Huskins WC, McGee R, Schurr K, Shapiro ED, Spencer KC, Sorkness CA. Training mentors of clinical and translational research scholars: a randomized controlled trial. Acad Med. 2014 May;89(5):774-82. PubMed PMID: 24667509
• Tanaka T, Doe JM, Horstmann SA, Ahmad S, Ahmad A, Min SJ, Reynolds PR, Suram S, Gaydos J, Burnham EL, Vandivier RW. Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells. J Biol Chem. 2014 Apr 11;289(15):10466-75. PubMed PMID: 24570000
• Burnham EL. 24/7 attendings: "helicoptering" the housestaff?. Pediatrics. 2014 Jan;133(1):131-3. PubMed PMID: 24323999
• Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014 Jan;43(1):276-85. PubMed PMID: 23520315
• Macht M, King CJ, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Post-extubation dysphagia is associated with longer hospitalization in survivors of critical illness with neurologic impairment. Crit Care. 2013 Jun 20;17(3):R119. [Epub ahead of print] PubMed PMID: 23786755
• Clark BJ, Bull TM, Benson AB, Stream AR, Macht M, Gaydos J, Meadows C, Burnham EL, Moss M, the ARDS Network Investigators. Growth differentiation factor-15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study. Crit Care. 2013 May 24;17(3):R92. [Epub ahead of print] PubMed PMID: 23706007
• Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 Feb 2. [Epub ahead of print] PubMed PMID: 26839359
• Afshar M, Foster CL, Layden JE, Burnham EL. Azithromycin use and outcomes in severe sepsis patients with and without pneumonia. J Crit Care. 2015 Dec 21. [Epub ahead of print] PubMed PMID: 26803186
• O'Halloran EB, Curtis BJ, Afshar M, Chen MM, Kovacs EJ, Burnham EL. Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders. Alcohol. 2015 Nov 24. [Epub ahead of print] PubMed PMID: 26781212
• Gaydos J, McNally A, Guo R, Vandivier RW, Simonian PL, Burnham EL. Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 8;:ajplung.00242.2015. [Epub ahead of print] PubMed PMID: 26747782
• Wehrmann F, Lavelle JC, Collins CB, Tinega AN, Thurman JM, Burnham EL, Simonian PL. ?d T cells protect against LPS-induced lung injury. J Leukoc Biol. 2016 Feb;99(2):373-86. PubMed PMID: 26428678
• Bailey KL, Romberger DJ, Katafiasz DM, Heires AJ, Sisson JH, Wyatt TA, Burnham EL. TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders. Alcohol Clin Exp Res. 2015 Sep;39(9):1691-7. PubMed PMID: 26208141
• Obianyo O, Liang Y, Burnham EL, Mehta A, Park Y, Uppal K, Harris FL, Jones DP, Brown LA. Metabolic Consequences of Chronic Alcohol Abuse in Non-Smokers: A Pilot Study. PLoS One. 2015;10(6):e0129570. PubMed PMID: 26102199
• Biehl JR, Burnham EL. Cannabis Smoking in 2015: A Concern for Lung Health?. Chest. 2015 Sep;148(3):596-606. PubMed PMID: 25996274
• Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S1-2. PubMed PMID: 25830827
• Aschner Y, Burnham EL. Adjuvant Therapies for ARDS: Not Ready for Prime Time?. Ann Am Thorac Soc. 2017 Jan;14(1):14-16. PubMed PMID: 28035871
• Yeligar SM, Chen MM, Kovacs EJ, Sisson JH, Burnham EL, Brown LA. Alcohol and lung injury and immunity. Alcohol. 2016 Sep;55:51-59. PubMed PMID: 27788778
• Burnham EL, McNally A, Gaydos J, Brown LA. The Relationship Between Airway Antioxidant Levels, Alcohol Use Disorders, and Cigarette Smoking. Alcohol Clin Exp Res. 2016 Oct;40(10):2147-2160. PubMed PMID: 27627733
• Sottile PD, Kiser TH, Burnham EL, Ho PM, Allen RR, Vandivier RW, Moss M. An Observational Study of the Efficacy of Cisatracurium Compared to Vecuronium in Patients with or at Risk for ARDS. Am J Respir Crit Care Med. 2017 Dec 14. [Epub ahead of print] PubMed PMID: 29241014
• Nick JA, Caceres SM, Kret JE, Poch KR, Strand M, Faino AV, Nichols DP, Saavedra MT, Taylor-Cousar JL, Geraci MW, Burnham EL, Fessler MB, Suratt BT, Abraham E, Moss M, Malcolm KC. Extremes of Interferon-Stimulated Gene Expression Associate with Worse Outcomes in the Acute Respiratory Distress Syndrome. PLoS One. 2016 Sep 8;11(9):e0162490. PubMed PMID: 27606687
• Frankel JH, Boe DM, Albright JM, O'Halloran EB, Carter SR, Davis CS, Ramirez L, Burnham EL, Gamelli RL, Afshar M, Kovacs EJ. Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes. Exp Gerontol. 2017 Oct 26. [Epub ahead of print] PubMed PMID: 29080833
• Cannon AR, Morris NL, Hammer AM, Curtis B, Remick DG, Yeligar SM, Poole L, Burnham EL, Wyatt TA, Molina PE, So-Armah K, Cisneros T, Wang G, Lang CH, Mandrekar P, Kovacs EJ, Choudhry MA. Alcohol and inflammatory responses: Highlights of the 2015 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2016 Aug;54:73-7. PubMed PMID: 27522326
• Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. Outcomes of ICU Patients With a Discharge Diagnosis of Critical Illness Polyneuromyopathy: A Propensity-Matched Analysis. Crit Care Med. 2017 Dec;45(12):2055-2060. PubMed PMID: 29019851
• Burnham EL, Roman J. Composition of the Sepsis Definitions Task Force. JAMA. 2016 Jul 26;316(4):460-1. PubMed PMID: 27458965
• Sapkota M, Burnham EL, DeVasure JM, Sweeter JM, Hunter CD, Duryee MJ, Klassen LW, Kharbanda KK, Sisson JH, Thiele GM, Wyatt TA. Malondialdehyde-Acetaldehyde (MAA) Protein Adducts Are Found Exclusively in the Lungs of Smokers with Alcohol Use Disorders and Are Associated with Systemic Anti-MAA Antibodies. Alcohol Clin Exp Res. 2017 Dec;41(12):2093-2099. PubMed PMID: 28941289
• Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20;9(408). PubMed PMID: 28931657
• Afshar M, Netzer G, Mosier MJ, Cooper RS, Adams W, Burnham EL, Kovacs EJ, Durazo-Arvizu R, Kliethermes S. The Contributing Risk of Tobacco Use for ARDS Development in Burn-Injured Adults With Inhalation Injury. Respir Care. 2017 Nov;62(11):1456-1465. PubMed PMID: 28900039
• Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 Feb 2. [Epub ahead of print] PubMed PMID: 26839359
• Afshar M, Foster CL, Layden JE, Burnham EL. Azithromycin use and outcomes in severe sepsis patients with and without pneumonia. J Crit Care. 2016 Apr;32:120-5. PubMed PMID: 26803186
• Samuelson DR, Burnham EL, Maffei VJ, Vandivier RW, Blanchard EE, Shellito JE, Luo M, Taylor CM, Welsh DA. The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 31;:ajplung.00277.2017. [Epub ahead of print] PubMed PMID: 28860145
• Fini MA, Gaydos J, McNally A, Karoor V, Burnham EL. Alcohol abuse is associated with enhanced pulmonary and systemic xanthine oxidoreductase activity. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1047-L1057. PubMed PMID: 28839105
• O'Halloran EB, Curtis BJ, Afshar M, Chen MM, Kovacs EJ, Burnham EL. Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders. Alcohol. 2016 Feb;50:43-50. PubMed PMID: 26781212
• Nedumaran B, Rudra P, Gaydos J, Kumar S, Meacham RB, Burnham EL, Malykhina AP. Impact of Regular Cannabis Use on Biomarkers of Lower Urinary Tract Function. Urology. 2017 Nov;109:223.e9-223.e16. PubMed PMID: 28827195
• Gaydos J, McNally A, Guo R, Vandivier RW, Simonian PL, Burnham EL. Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15;310(6):L507-18. PubMed PMID: 26747782
• Wehrmann F, Lavelle JC, Collins CB, Tinega AN, Thurman JM, Burnham EL, Simonian PL. ?d T cells protect against LPS-induced lung injury. J Leukoc Biol. 2016 Feb;99(2):373-86. PubMed PMID: 26428678
• Afshar M, Burnham EL, Joyce C, Clark BJ, Yong M, Gaydos J, Cooper RS, Smith GS, Kovacs EJ, Lowery EM. Cut-Point Levels of Phosphatidylethanol to Identify Alcohol Misuse in a Mixed Cohort Including Critically Ill Patients. Alcohol Clin Exp Res. 2017 Oct;41(10):1745-1753. PubMed PMID: 28792620
• Blumhagen RZ, Hedin BR, Malcolm KC, Burnham EL, Moss M, Abraham E, Huie TJ, Nick JA, Fingerlin TE, Alper S. Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L930-L939. PubMed PMID: 28775099
• Clark BJ, Jones J, Reed KD, Hodapp R, Douglas IS, Van Pelt D, Burnham EL, Moss M. The Experience of Patients with Alcohol Misuse after Surviving a Critical Illness. A Qualitative Study. Ann Am Thorac Soc. 2017 Jul;14(7):1154-1161. PubMed PMID: 28406727
• Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS. Gender Parity in Critical Care Medicine. Am J Respir Crit Care Med. 2017 Aug 15;196(4):425-429. PubMed PMID: 28240961
• Abdul-Muneer PM, Alikunju S, Mishra V, Schuetz H, Szlachetka AM, Burnham EL, Haorah J. Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. Brain Behav Immun. 2017 May;62:291-305. PubMed PMID: 28232172
• Aschner Y, Burnham EL. Adjuvant Therapies for ARDS: Not Ready for Prime Time?. Ann Am Thorac Soc. 2017 Jan;14(1):14-16. PubMed PMID: 28035871
• Reynolds PM, Van Matre ET, Wright GC, McQueen RB, Burnham EL, Michael Ho P, Moss M, Vandivier RW, Kiser TH. Evaluation of prophylactic heparin dosage strategies and risk factors for venous thromboembolism in the critically ill patient. Pharmacotherapy. 2018 Dec 28. [Epub ahead of print] PubMed PMID: 30592541
• Kiser TH, Burnham EL, Clark B, Ho PM, Allen RR, Moss M, Vandivier RW. The authors reply. Crit Care Med. 2018 Dec;46(12):e1224-e1225. PubMed PMID: 30444823
• Bailey KL, Wyatt TA, Katafiasz DM, Taylor KW, Heires AJ, Sisson JH, Romberger DJ, Burnham EL. Alcohol and Cannabis Use Alter Pulmonary Innate Immunity. Alcohol. 2018 Nov 9. [Epub ahead of print] PubMed PMID: 30419300
• Van Matre ET, Reynolds PM, MacLaren R, Mueller SW, Wright GC, Moss M, Burnham EL, Ho PM, Vandivier RW, Kiser TH. Evaluation of unfractionated heparin versus low-molecular-weight heparin and fondaparinux for pharmacologic venous thromboembolic prophylaxis in critically ill patients with cancer. J Thromb Haemost. 2018 Dec;16(12):2492-2500. PubMed PMID: 30347498
• Gaydos J, McNally A, Burnham EL. The Impact of Alcohol Use Disorders on Pulmonary Immune Cell Inflammatory Responses to Streptococcus pneumoniae. Alcohol. 2018 Sep 5. [Epub ahead of print] PubMed PMID: 30195043
• Afshar M, Burnham EL, Joyce C, Kovacs EJ, Lowery EM. Optimal Cut-Points for Phosphatidylethanol Vary by Clinical Setting: Response to Nguyen and Seth's (2018) Letter to the Editor. Alcohol Clin Exp Res. 2018 Oct;42(10):2064-2065. PubMed PMID: 30059162
• Kiser TH, Burnham EL, Clark B, Ho PM, Allen RR, Moss M, Vandivier RW. Half-Dose Versus Full-Dose Alteplase for Treatment of Pulmonary Embolism. Crit Care Med. 2018 Oct;46(10):1617-1625. PubMed PMID: 29979222
• Breathett K, Liu WG, Allen LA, Daugherty SL, Blair IV, Jones J, Grunwald GK, Moss M, Kiser TH, Burnham E, Vandivier RW, Clark BJ, Lewis EF, Mazimba S, Battaglia C, Ho PM, Peterson PN. African Americans Are Less Likely to Receive Care by a Cardiologist During an Intensive Care Unit Admission for Heart Failure. JACC Heart Fail. 2018 May;6(5):413-420. PubMed PMID: 29724363
• Afshar M, Burnham EL, Joyce C, Gagnon R, Dunn R, Albright JM, Ramirez L, Repine JE, Netzer G, Kovacs EJ. Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury: Development and Internal Validation. Ann Surg. 2018 Apr 24. [Epub ahead of print] PubMed PMID: 29697443
• Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. The authors reply. Crit Care Med. 2018 Apr;46(4):e347-e348. PubMed PMID: 29538131
• Sottile PD, Kiser TH, Burnham EL, Ho PM, Allen RR, Vandivier RW, Moss M. An Observational Study of the Efficacy of Cisatracurium Compared with Vecuronium in Patients with or at Risk for Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Apr 1;197(7):897-904. PubMed PMID: 29241014
• Tanabe J, Yamamoto DJ, Sutton B, Brown MS, Hoffman PL, Burnham EL, Glueck DH, Tabakoff B. Effects of Alcohol and Acetate on Cerebral Blood Flow: A Pilot Study. Alcohol Clin Exp Res. 2019 Oct;43(10):2070-2078. PubMed PMID: 31386214
• Frankel JH, Boe DM, Albright JM, O'Halloran EB, Carter SR, Davis CS, Ramirez L, Burnham EL, Gamelli RL, Afshar M, Kovacs EJ. Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes. Exp Gerontol. 2018 May;105:78-86. PubMed PMID: 29080833
• Burns KEA, Burnham EL, Dodek PM, Moss M. Unconscious bias in the selection and interpretation of data on sex and burnout - Authors' reply. Lancet Respir Med. 2019 Aug;7(8):e24. PubMed PMID: 31342898
• Prohaska CC, Sottile PD, Nordon-Craft A, Gallagher MD, Burnham EL, Clark BJ, Ho M, Kiser TH, Vandivier RW, Liu W, Schenkman M, Moss M. Patterns of utilization and effects of hospital-specific factors on physical, occupational, and speech therapy for critically ill patients with acute respiratory failure in the USA: results of a 5-year sample. Crit Care. 2019 May 16;23(1):175. PubMed PMID: 31097017
• Samuelson DR, Burnham EL, Maffei VJ, Vandivier RW, Blanchard EE, Shellito JE, Luo M, Taylor CM, Welsh DA. The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L107-L117. PubMed PMID: 28860145
• Burnham EL, Burns KEA, Moss M, Dodek PM. Burnout in women intensivists: a hidden epidemic?. Lancet Respir Med. 2019 Apr;7(4):292-294. PubMed PMID: 30744938
• Burnham EL, Eakin MN, Pakhale S. Ethics of Health Research Supported by For-Profit Cannabis Companies: What Have We Learned from Big Tobacco?. Ann Am Thorac Soc. 2019 Mar;16(3):396-397. PubMed PMID: 30712358
• Kiser TH, Reynolds PM, Moss M, Burnham EL, Ho PM, Vandivier RW. Impact of Macrolide Antibiotics on Hospital Readmissions and Other Clinically Important Outcomes in Critically Ill Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Propensity Score-Matched Cohort Study. Pharmacotherapy. 2019 Mar;39(3):242-252. PubMed PMID: 30663791
• Reynolds PM, Van Matre ET, Wright GC, McQueen RB, Burnham EL, Ho PJM, Moss M, Vandivier RW, Kiser TH. Evaluation of Prophylactic Heparin Dosage Strategies and Risk Factors for Venous Thromboembolism in the Critically Ill Patient. Pharmacotherapy. 2019 Mar;39(3):232-241. PubMed PMID: 30592541
• Bailey KL, Wyatt TA, Katafiasz DM, Taylor KW, Heires AJ, Sisson JH, Romberger DJ, Burnham EL. Alcohol and cannabis use alter pulmonary innate immunity. Alcohol. 2019 Nov;80:131-138. PubMed PMID: 30419300
• Gaydos J, McNally A, Burnham EL. The impact of alcohol use disorders on pulmonary immune cell inflammatory responses to Streptococcus pneumoniae. Alcohol. 2019 Nov;80:119-130. PubMed PMID: 30195043
• Afshar M, Burnham EL, Joyce C, Gagnon R, Dunn R, Albright JM, Ramirez L, Repine JE, Netzer G, Kovacs EJ. Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury: Development and Internal Validation. Ann Surg. 2019 Dec;270(6):1186-1193. PubMed PMID: 29697443
• Hua J, Afshar M, Clark BJ, Kovacs EJ, Burnham EL. The Relationship of Cannabis Decriminalization in Colorado and Cannabis Use in Individuals with Alcohol Use Disorders. Journal of Cannabis Research. 2020 In press.
• Clark BJ, Keniston A, Douglas IS, Beresford T, Macht M, Williams A, Jones J, Burnham EL, Moss M. Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal. Alcohol Clin Exp Res. 2013 Sep;37(9):1536-43. PubMed PMID: 23647435
• Burnham EL, Kovacs EJ, Davis CS. Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L873-82. PubMed PMID: 23605000
• Afshar M, Baker K, Corral J, Ross E, Lowery E, Gonzalez R, Burnham EL, Callcut RA, Kornblith LZ, Hendrickson C, Kovacs EJ, Joyce C. Internal and External Validation of an Alcohol Biomarker for Screening in Trauma. Ann Surg. 2021 Feb 1. [Epub ahead of print] PubMed PMID: 33534233
• Hua JT, Afshar M, Clark BJ, Kovacs EJ, Burnham EL. The relationship of cannabis decriminalization in Colorado and cannabis use in individuals with alcohol use disorders. J Cannabis Res. 2020 Mar 2;2(1):13. PubMed PMID: 33526125
• Clark BJ, Williams A, Feemster LM, Bradley KA, Macht M, Moss M, Burnham EL. Alcohol screening scores and 90-day outcomes in patients with acute lung injury. Crit Care Med. 2013 Jun;41(6):1518-25. PubMed PMID: 23538449
• Althoff MD, Holguin F, Yang F, Grunwald GK, Moss M, Vandivier RW, Ho PM, Kiser TH, Burnham EL. Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations. Am J Respir Crit Care Med. 2020 Dec 1;202(11):1520-1530. PubMed PMID: 32663410
• Bowden K, Burnham EL, Keniston A, Levin D, Limes J, Persoff J, Thurman L, Burden M. Harnessing the Power of Hospitalists in Operational Disaster Planning: COVID-19. J Gen Intern Med. 2020 Sep;35(9):2732-2737. PubMed PMID: 32661930
• Burnham EL, Hyzy RC, Paine R 3rd, Coley C 2nd, Kelly AM, Quint LE, Lynch D, Janssen WJ, Moss M, Standiford TJ. Chest CT features are associated with poorer quality of life in acute lung injury survivors. Crit Care Med. 2013 Feb;41(2):445-56. PubMed PMID: 23263616
• Finigan JH, Mishra R, Vasu VT, Silveira LJ, Nethery DE, Standiford TJ, Burnham EL, Moss M, Kern JA. Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation. Eur Respir J. 2013 Feb;41(2):396-401. PubMed PMID: 22599357
• Fleming M, Burnham EL, Huskins WC. Mentoring translational science investigators. JAMA. 2012 Nov 21;308(19):1981-2. PubMed PMID: 23168821
• Clark BJ, Smart A, House R, Douglas I, Burnham EL, Moss M. Severity of acute illness is associated with baseline readiness to change in medical intensive care unit patients with unhealthy alcohol use. Alcohol Clin Exp Res. 2012 Mar;36(3):544-51. PubMed PMID: 21950704
• Baker TA, Davis CS, Bach HH 4th, Romero J, Burnham EL, Kovacs EJ, Gamelli RL, Majetschak M. Ubiquitin and stromal cell-derived factor-1a in bronchoalveolar lavage fluid after burn and inhalation injury. J Burn Care Res. 2012 Jan-Feb;33(1):57-64. PubMed PMID: 22105097
• Bailey KL, Smith H, Mathai SK, Huber J, Yacoub M, Yang IV, Wyatt TA, Kechris K, Burnham EL. Alcohol Use Disorders Are Associated With a Unique Impact on Airway Epithelial Cell Gene Expression. Alcohol Clin Exp Res. 2020 Aug;44(8):1571-1584. PubMed PMID: 32524622
• Paine R 3rd, Standiford TJ, Dechert RE, Moss M, Martin GS, Rosenberg AL, Thannickal VJ, Burnham EL, Brown MB, Hyzy RC. A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury. Crit Care Med. 2012 Jan;40(1):90-7. PubMed PMID: 21926600
• Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Diagnosis and treatment of post-extubation dysphagia: results from a national survey. J Crit Care. 2012 Dec;27(6):578-86. PubMed PMID: 23084136
• Hippensteel JA, Burnham EL, Jolley SE. Prevalence of venous thromboembolism in critically ill patients with COVID-19. Br J Haematol. 2020 Aug;190(3):e134-e137. PubMed PMID: 32484907
• Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM. Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia. Chest. 2012 Dec;142(6):1569-1576. PubMed PMID: 22797508
• Liu C, Gaydos J, Johnson-Paben R, Kechris K, Burnham EL, Sharma S. Chronic Marijuana Use Is Associated with Gene Expression Changes in BAL. Am J Respir Cell Mol Biol. 2022 Feb;66(2):238-239. PubMed PMID: 35103554
• Burnham EL, McCord JM, Bose S, Brown LA, House R, Moss M, Gaydos J. Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L688-99. PubMed PMID: 22268125
• Dyamenahalli K, Choy K, Frank DN, Najarro K, Boe D, Colborn KL, Idrovo JP, Wagner AL, Wiktor AJ, Afshar M, Burnham EL, McMahan RH, Kovacs EJ. Age and injury size influence the magnitude of fecal dysbiosis in adult burn patients. J Burn Care Res. 2022 Jan 10. [Epub ahead of print] PubMed PMID: 35020913
• Albright JM, Davis CS, Bird MD, Ramirez L, Kim H, Burnham EL, Gamelli RL, Kovacs EJ. The acute pulmonary inflammatory response to the graded severity of smoke inhalation injury. Crit Care Med. 2012 Apr;40(4):1113-21. PubMed PMID: 22067627
• Steel TL, Afshar M, Edwards S, Jolley SE, Timko C, Clark BJ, Douglas IS, Dzierba AL, Gershengorn HB, Gilpin NW, Godwin DW, Hough CL, Maldonado JR, Mehta AB, Nelson LS, Patel MB, Rastegar DA, Stollings JL, Tabakoff B, Tate JA, Wong A, Burnham EL. Research Needs for Inpatient Management of Severe Alcohol Withdrawal Syndrome: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2021 Oct 1;204(7):e61-e87. PubMed PMID: 34609257
• Fisichella PM, Davis CS, Lundberg PW, Lowery E, Burnham EL, Alex CG, Ramirez L, Pelletiere K, Love RB, Kuo PC, Kovacs EJ. The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery. 2011 Oct;150(4):598-606. PubMed PMID: 22000170
• Sacha GL, Kiser TH, Wright GC, Vandivier RW, Moss M, Burnham EL, Ho PM, Reynolds PM, Bauer SR. Association Between Vasopressin Rebranding and Utilization in Patients With Septic Shock. Crit Care Med. 2021 Oct 4. [Epub ahead of print] PubMed PMID: 34605778
• Burnham EL, Schiro S, Fleming M. Mentoring K scholars: strategies to support research mentors. Clin Transl Sci. 2011 Jun;4(3):199-203. PubMed PMID: 21707951
• Neff S, Drake MG, Slatore CG, Burnham E. Inhaled Marijuana and the Lungs. Am J Respir Crit Care Med. 2021 Sep 1;204(5):P9-P10. PubMed PMID: 34499025
• Carmichael H, Wright FL, McIntyre RC, Vogler T, Urban S, Jolley SE, Burnham EL, Firth W, Velopulos CG, Idrovo JP. Early ventilator liberation and decreased sedation needs after tracheostomy in patients with COVID-19 infection. Trauma Surg Acute Care Open. 2021;6(1):e000591. PubMed PMID: 34192162
• Majka S, Burnham E, Stenmark KR. Cell-based therapies in pulmonary hypertension: who, what, and when?. Am J Physiol Lung Cell Mol Physiol. 2011 Jul;301(1):L9-L11. PubMed PMID: 21515661
• Wyatt TA, Warren KJ, Wetzel TJ, Suwondo T, Rensch GP, DeVasure JM, Mosley DD, Kharbanda KK, Thiele GM, Burnham EL, Bailey KL, Yeligar SM. Malondialdehyde-Acetaldehyde Adduct Formation Decreases Immunoglobulin A Transport across Airway Epithelium in Smokers Who Abuse Alcohol. Am J Pathol. 2021 Oct;191(10):1732-1742. PubMed PMID: 34186073
• Tanabe J, Neff S, Sutton B, Ellis S, Patten L, Brown MS, Hoffman PL, Tabakoff B, Burnham EL. Effects of acetate on cerebral blood flow, systemic inflammation, and behavior in alcohol use disorder. Alcohol Clin Exp Res. 2021 May;45(5):922-933. PubMed PMID: 33682145
• Afshar M, Baker K, Corral J, Ross E, Lowery E, Gonzalez R, Burnham EL, Callcut RA, Kornblith LZ, Hendrickson C, Kovacs EJ, Joyce C. Internal and External Validation of an Alcohol Biomarker for Screening in Trauma. Ann Surg. 2021 Mar 10. [Epub ahead of print] PubMed PMID: 33534233
• Burnham EL, Phang TL, House R, Vandivier RW, Moss M, Gaydos J. Alveolar macrophage gene expression is altered in the setting of alcohol use disorders. Alcohol Clin Exp Res. 2011 Feb;35(2):284-94. PubMed PMID: 21121937
• Burnham EL, Fleming M. Selection of research mentors for K-funded scholars. Clin Transl Sci. 2011 Apr;4(2):87-92. PubMed PMID: 21463493
• Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illness. Crit Care. 2011;15(5):R231. PubMed PMID: 21958475
• Malcolm KC, Kret JE, Young RL, Poch KR, Caceres SM, Douglas IS, Coldren CD, Burnham EL, Moss M, Nick JA. Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome. PLoS One. 2011;6(7):e21958. PubMed PMID: 21755013
• Burnham EL, Gaydos J, Hess E, House R, Cooper J. Alcohol use disorders affect antimicrobial proteins and anti-pneumococcal activity in epithelial lining fluid obtained via bronchoalveolar lavage. Alcohol Alcohol. 2010 Sep-Oct;45(5):414-21. PubMed PMID: 20729531
• Burnham EL, Mealer M, Gaydos J, Majka S, Moss M. Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells. Am J Respir Cell Mol Biol. 2010 Sep;43(3):326-33. PubMed PMID: 19843706
• Boé DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, Moss M, Vandivier RW. Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res. 2010 Oct;34(10):1723-32. PubMed PMID: 20608904
• Burnham EL, Moss M, Geraci MW. The case for 24/7 in-house intensivist coverage. Am J Respir Crit Care Med. 2010 Jun 1;181(11):1159-60. PubMed PMID: 20516489
• Boé DM, Vandivier RW, Burnham EL, Moss M. Alcohol abuse and pulmonary disease. J Leukoc Biol. 2009 Nov;86(5):1097-104. PubMed PMID: 19602670
• Jolley SE, Mowry CJ, Erlandson KM, Wilson MP, Burnham EL. Impact of Alcohol Misuse on Requirements for Critical Care Services and Development of Hospital Delirium in Patients With COVID-19 pneumonia. Crit Care Explor. 2023 Jan;5(1):e0829. PubMed PMID: 36713630
• Choy K, Dyamenahalli KU, Khair S, Colborn KL, Wiktor AJ, Idrovo JP, McMahan RH, Burnham EL, Kovacs EJ. Aberrant Inflammatory Responses in Intoxicated Burn Injured Patients Parallel Impaired Cognitive Function. Alcohol. 2023 Jan 20. [Epub ahead of print] PubMed PMID: 36690221
• Park BD, Kannappan A, Rizzo AN, Jin Y, Peterson RA, Burnham E, Moss M, Jolley S. Relationship Between a State-Directed Lockdown on Non-COVID-19-related ICU Admissions and Mortality in a Multicenter Colorado Healthcare System. Crit Care Explor. 2022 Dec;4(12):e0791. PubMed PMID: 36506833
• Burns KEA, Moss M, Lorens E, Jose EKA, Martin CM, Viglianti EM, Fox-Robichaud A, Mathews KS, Akgun K, Jain S, Gershengorn H, Mehta S, Han JE, Martin GS, Liebler JM, Stapleton RD, Trachuk P, Vranas KC, Chua A, Herridge MS, Tsang JLY, Biehl M, Burnham EL, Chen JT, Attia EF, Mohamed A, Harkins MS, Soriano SM, Maddux A, West JC, Badke AR, Bagshaw SM, Binnie A, Carlos WG, Çoruh B, Crothers K, D'Aragon F, Denson JL, Drover JW, Eschun G, Geagea A, Griesdale D, Hadler R, Hancock J, Hasmatali J, Kaul B, Kerlin MP, Kohn R, Kutsogiannis DJ, Matson SM, Morris PE, Paunovic B, Peltan ID, Piquette D, Pirzadeh M, Pulchan K, Schnapp LM, Sessler CN, Smith H, Sy E, Thirugnanam S, McDonald RK, McPherson KA, Kraft M, Spiegel M, Dodek PM. Wellness and Coping of Physicians Who Worked in ICUs During the Pandemic: A Multicenter Cross-Sectional North American Survey. Crit Care Med. 2022 Dec 1;50(12):1689-1700. PubMed PMID: 36300945
• Burnham EL, Halkar R, Burks M, Moss M. The effects of alcohol abuse on pulmonary alveolar-capillary barrier function in humans. Alcohol Alcohol. 2009 Jan-Feb;44(1):8-12. PubMed PMID: 18567916
• Mealer M, Burnham EL, Goode CJ, Rothbaum B, Moss M. The prevalence and impact of post traumatic stress disorder and burnout syndrome in nurses. Depress Anxiety. 2009;26(12):1118-26. PubMed PMID: 19918928
• de Wit M, Gennings C, Zilberberg M, Burnham EL, Moss M, Balster RL. Drug withdrawal, cocaine and sedative use disorders increase the need for mechanical ventilation in medical patients. Addiction. 2008 Sep;103(9):1500-8. PubMed PMID: 18636996
• Graham BB, Burnham EL, Janssen JS, Janssen WJ. Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter. Chest. 2008 Nov;134(5):1074-1079. PubMed PMID: 18988783
• Zakrajsek JK, Min SJ, Ho PM, Kiser TH, Kannappan A, Sottile PD, Allen RR, Althoff MD, Reynolds PM, Moss M, Burnham EL, Mikkelsen ME, Vandivier RW. Extracorporeal Membrane Oxygenation for Refractory Asthma Exacerbations With Respiratory Failure. Chest. 2023 Jan;163(1):38-51. PubMed PMID: 36191634
• Burnham EL. Circulating progenitors in lung injury: a novel therapy for acute respiratory distress syndrome?. Anesthesiology. 2008 Mar;108(3):354-6. PubMed PMID: 18292671
• Yeh MY, Burnham EL, Moss M, Brown LA. Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics. Respir Med. 2008 Feb;102(2):248-55. PubMed PMID: 17977706
• Chockalingam L, Burnham EL, Jolley SE. Medication prescribing for alcohol use disorders during alcohol-related encounters in a Colorado regional healthcare system. Alcohol Clin Exp Res. 2022 Jun;46(6):1094-1102. PubMed PMID: 35723682
• Aschner Y, Correll KA, Beke KM, Foster DG, Roybal HM, Nelson MR, Meador CL, Strand M, Anderson KC, Moore CM, Reynolds PR, Kopf KW, Burnham EL, Downey GP. PTPa promotes fibroproliferative responses after acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L69-L83. PubMed PMID: 35670474
• Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD. I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations. BMJ Open. 2022 Jun 6;12(6):e060664. PubMed PMID: 35667714
• Kim E, Mathai SK, Stancil IT, Ma X, Hernandez-Gutierrez A, Becerra JN, Marrero-Torres E, Hennessy CE, Hatakka K, Wartchow EP, Estrella A, Huber JP, Cardwell JH, Burnham EL, Zhang Y, Evans CM, Vladar EK, Schwartz DA, Dobrinskikh E, Yang IV. Aberrant Multiciliogenesis in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 Aug;67(2):188-200. PubMed PMID: 35608953
• Medepalli K, Purdon S, Bade RM, Glassberg MK, Burnham EL, Gershengorn HB. Association of Women Leaders with Women Program Director and Trainee Representation Across US Academic Internal Medicine. J Gen Intern Med. 2023 Jan;38(1):57-66. PubMed PMID: 35604632
• Majka SM, Skokan M, Wheeler L, Harral J, Gladson S, Burnham E, Loyd JE, Stenmark KR, Varella-Garcia M, West J. Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L1028-39. PubMed PMID: 18931051
• Burnham EL. Identification of risky alcohol consumption in the preoperative assessment: opportunity to diagnose and intervene. Anesthesiology. 2008 Aug;109(2):169-70. PubMed PMID: 18648224
• Martin J, Helm K, Ruegg P, Varella-Garcia M, Burnham E, Majka S. Adult lung side population cells have mesenchymal stem cell potential. Cytotherapy. 2008;10(2):140-51. PubMed PMID: 18368593
• de Wit M, Best AM, Gennings C, Burnham EL, Moss M. Alcohol use disorders increase the risk for mechanical ventilation in medical patients. Alcohol Clin Exp Res. 2007 Jul;31(7):1224-30. PubMed PMID: 17511746
• Yeh MY, Burnham EL, Moss M, Brown LA. Chronic alcoholism alters systemic and pulmonary glutathione redox status. Am J Respir Crit Care Med. 2007 Aug 1;176(3):270-6. PubMed PMID: 17507544
• Bailey KL, Sayles H, Campbell J, Khalid N, Anglim M, Ponce J, Wyatt TA, McClay JC, Burnham EL, Anzalone A, Hanson C. COVID-19 patients with documented alcohol use disorder or alcohol-related complications are more likely to be hospitalized and have higher all-cause mortality. Alcohol Clin Exp Res. 2022 Jun;46(6):1023-1035. PubMed PMID: 35429004
• Liu C, Gaydos J, Johnson-Paben R, Kechris K, Burnham EL, Sharma S. Chronic Marijuana Use Is Associated with Gene Expression Changes in BAL. Am J Respir Cell Mol Biol. 2022 Feb;66(2):238-239. PubMed PMID: 35103554
• Dyamenahalli K, Choy K, Frank DN, Najarro K, Boe D, Colborn KL, Idrovo JP, Wagner AL, Wiktor AJ, Afshar M, Burnham EL, McMahan RH, Kovacs EJ. Age and Injury Size Influence the Magnitude of Fecal Dysbiosis in Adult Burn Patients. J Burn Care Res. 2022 Sep 1;43(5):1145-1153. PubMed PMID: 35020913
• Sacha GL, Kiser TH, Wright GC, Vandivier RW, Moss M, Burnham EL, Ho PM, Reynolds PM, Bauer SR. Association Between Vasopressin Rebranding and Utilization in Patients With Septic Shock. Crit Care Med. 2022 Apr 1;50(4):644-654. PubMed PMID: 34605778
• Burnham EL, Moss M, Ritzenthaler JD, Roman J. Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Alcohol Clin Exp Res. 2007 Apr;31(4):675-83. PubMed PMID: 17374047
• Afshar M, Baker K, Corral J, Ross E, Lowery E, Gonzalez R, Burnham EL, Callcut RA, Kornblith LZ, Hendrickson C, Kovacs EJ, Joyce C. Internal and External Validation of an Alcohol Biomarker for Screening in Trauma. Ann Surg. 2022 Dec 1;276(6):e961-e968. PubMed PMID: 33534233
• Khan J, Burnham EL, Moss M. Acquired weakness in the ICU: critical illness myopathy and polyneuropathy. Minerva Anestesiol. 2006 Jun;72(6):401-6. PubMed PMID: 16682908
• Esper A, Burnham EL, Moss M. The effect of alcohol abuse on ARDS and multiple organ dysfunction. Minerva Anestesiol. 2006 Jun;72(6):375-81. PubMed PMID: 16682904
• Burnham E, Moss M. Progenitor cells in acute lung injury. Minerva Anestesiol. 2006 Jun;72(6):369-74. PubMed PMID: 16682903
• Mayer KP, Palakshappa JA, Peltan ID, Andrew JS, Gundel SJ, Ringwood NJ, Mckeehan J, Hope AA, Rogers AJ, Biehl M, Hayden DL, Caldwell E, Mehkri O, Lynch DJ, Burham EL, Hough CL, Jolley SE. Functional, imaging, and respiratory evaluation (FIRE) of patients post-hospitalization for COVID-19: protocol for a pilot observational study. Pilot Feasibility Stud. 2022 Sep 19;8(1):212. PubMed PMID: 36123599
• Moss M, Burnham EL. Alcohol abuse in the critically ill patient. Lancet. 2006 Dec 23;368(9554):2231-42. PubMed PMID: 17189035
• Burnham EL, Moss M, Ziegler TR. Myopathies in critical illness: characterization and nutritional aspects. J Nutr. 2005 Jul;135(7):1818S-1823S. PubMed PMID: 15987872
• Mikacenic C, Fussner LA, Bell J, Burnham EL, Chlan LL, Cook SK, Dickson RP, Almonor F, Luo F, Madan K, Morales-Nebreda L, Mould KJ, Simpson AJ, Singer BD, Stapleton RD, Wendt CH, Files DC. Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2023 May;20(5):621-631. PubMed PMID: 37125997
• Reynolds PM, Afshar M, Wright GC, Ho PM, Kiser TH, Sottile PD, Althoff MD, Moss M, Jolley SE, Vandivier RW, Burnham EL. Association between Substance Misuse and Outcomes in Critically III Patients with Pneumonia. Ann Am Thorac Soc. 2023 Apr;20(4):556-565. PubMed PMID: 37000145
• Jolley SE, Mowry CJ, Erlandson KM, Wilson MP, Burnham EL. Impact of Alcohol Misuse on Requirements for Critical Care Services and Development of Hospital Delirium in Patients With COVID-19 pneumonia. Crit Care Explor. 2023 Jan;5(1):e0829. PubMed PMID: 36713630
• Choy K, Dyamenahalli KU, Khair S, Colborn KL, Wiktor AJ, Idrovo JP, McMahan RH, Burnham EL, Kovacs EJ. Aberrant inflammatory responses in intoxicated burn-injured patients parallel impaired cognitive function. Alcohol. 2023 Jun;109:35-41. PubMed PMID: 36690221
• Zakrajsek JK, Min SJ, Ho PM, Kiser TH, Kannappan A, Sottile PD, Allen RR, Althoff MD, Reynolds PM, Moss M, Burnham EL, Mikkelsen ME, Vandivier RW. Extracorporeal Membrane Oxygenation for Refractory Asthma Exacerbations With Respiratory Failure. Chest. 2023 Jan;163(1):38-51. PubMed PMID: 36191634
• Medepalli K, Purdon S, Bade RM, Glassberg MK, Burnham EL, Gershengorn HB. Association of Women Leaders with Women Program Director and Trainee Representation Across US Academic Internal Medicine. J Gen Intern Med. 2023 Jan;38(1):57-66. PubMed PMID: 35604632
• Burnham EL, Pomponio R, Perry G, Offner PJ, Ormesher R, Peterson RA, Jolley SE. Prevalence of Alcohol Use Characterized by Phosphatidylethanol in Patients With Respiratory Failure Before and During the COVID-19 Pandemic. CHEST Crit Care. 2024 Mar;2(1). PubMed PMID: 38818345
• Dunbar PJ, Peterson R, McGrath M, Pomponio R, Kiser TH, Ho PM, Vandivier RW, Burnham EL, Moss M, Sottile PD. Analgesia and Sedation Use During Noninvasive Ventilation for Acute Respiratory Failure. Crit Care Med. 2024 Jul 1;52(7):1043-1053. PubMed PMID: 38506571
• Hoisington AJ, Choy K, Khair S, Dyamenahalli KU, Najarro KM, Wiktor AJ, Frank DN, Burnham EL, McMahan RH, Kovacs EJ. Recent alcohol intake impacts microbiota in adult burn patients. Alcohol. 2024 Aug;118:25-35. PubMed PMID: 38604285

Professional Memberships

• American Thoracic Society, Member, Critical Care Assembly
• American Board of Internal Medicine, Pulmonary Exam Writing Committee
• Research Society on Alcoholism, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• Colorado Clinical & Translational Sciences Institute (CCTSI)

Specialty Information

Specialties

• Pulmonary Disease, Board Certification (2011, 2021)
• Critical Care Medicine, Board Certification (2012, 2022)

Conditions & Treatments

• Critical Care
• Lungs and Breathing - Pulmonary Disorders
• Lungs and Breathing
• Infections - Pneumonia
• Infections
• Infections - Viral Infections
• Infections - Influenza