Amie Meditz, MD

Publications

• Cubas RA, Mudd JC, Savoye A-L, Perreau M, van Grevenynghe J, Metcalf T, Connick E, Meditz AL, Freeman GJ, Abesada-Terk G, Jacobson JM, Brooks AD, Crotty S, Estes JD, Pantaleo G, Lederman MM, Haddad EK. Inadequate T follicular cell help impairs B cell immunity during HIV infection. Nature Medicine [In press].
• Meditz AL, Predhomme J, Searls K, Caraway P, Gardner EM, Zheng J, Bushman L, Anderson PL. Tenofovir Diphosphate in Dried Blood Spots (TFV-DP DBS) as an Objective Measure of Antiretroviral Medication Adherence in HIV-1-Infected Women. 20th Conference on Retroviruses and Opportunistic Infections, March 3-6, 2013 Abstract # T-165
• Castillo-Mancilla J, Rower J, Zheng J, Meditz AL, Gardner E, McAllister K, Klein B, Kiser J, Bushman L, Anderson PL. Tenofovir Diphosphate (TFV-DP) in Dried Blood Spots (DBS) in HIV-negative (HIV-) versus HIV-positive (HIV+) individuals. 20th Conference on Retroviruses and Opportunistic Infections, March 3-6, 2013 Abstract # J-131
• Castillo-Mancilla J, Zheng JH, Rower J, Meditz A, Gardner EM, Predhomme J, MaWhinney S, Anderson PL. Tenofovir, emtricitabine, and tenofovir-diphosphate in dried blood spots for determining recent and cumulative drug exposure. AIDS Res Hum Retroviruses. 2012 Aug 31; 29(2):384-90; PMID:22935078
• Moreau KL, Hildreth K, Meditz A, Deane K, Kohrt WM. Endothelial Function Is Impaired across the Stages of the Menopause Transition in Healthy Women. J Clin Endocrinol Metab, 2012 Sep 11; 97(12):4692-700. PMID:22969140.
• Rower JE, Meditz A, Gardner EM, Lichtenstein K, Predhomme J, Bushman LR, Klein B, Zheng JH, Mawhinney S, Anderson PL. The effect of HIV-1 infection and sex on the cellular pharmacology of the antiretroviral drugs zidovudine and lamivudine. Antimicrobial Agents and Chemotherapy. 2012 Jun;56(6):3011-9; PMID:22391541
• Meditz AL, Moreau K, Gozansky WS, Melander K, Kohrt W, Wierman M, Connick E. Healthy Postmenopausal Women Have Higher Percentages of CCR5+ Endocervical CD4+ T-Cells Compared to Premenopausal Women: Implications for HIV Transmission, JAIDS 2012; 59(3):221-228.
• Moreau KL, Meditz A, Deane K, Kohrt WM. TETRAHYDROBIOPTERIN IMPROVES ENDOTHELIAL FUNCTION AND DECREASES ARTERIAL STIFFNESS IN ESTROGEN-DEFICIENT POSTMENOPAUSAL WOMEN. American Journal of Physiology - Heart and Circulatory Physiology. January 13, 2012 in press.
• Rower JE, Meditz A, Gardner EM, Lichtenstein K, Predhomme J, Bushman LR, Klein B, Zheng JH, Mawhinney S, Anderson PL. The effect of HIV-1 infection and sex on the cellular pharmacology of the antiretroviral drugs zidovudine and lamivudine. Antimicrobial Agents and Chemotherapy. March 5, 2012 2012 in
• Meditz AL, Folkvord J, Nguyen N, Carroll K, Lie Y, Coakley E, McCarter M, MaWhinney S, Connick E. Lymph Node HIV-Producing Cells are Less Abundant and Associated with Lower Plasma HIV RNA in Women Compared to Men. 19th Conference on Retroviruses and Opportunistic Infections, Seattle, March 5-8, 2012. Abstract #D-196
• Anderson PL, Meditz AL, Zheng J, Predhomme J, Klein B, Guida L, McAllister K, Fernandez C, Kiser J, Bushman L. Cellular Pharmacology of Tenofovir (TFV) and Emtricitabine (FTC) in Blood, Rectal, and Cervical Cells from HIV-Negative Volunteers. 19th Conference on Retroviruses and Opportunistic Infections, Seattle, March 5-8, 2012. Abstract # N-118
• Castillo-Mancilla J, Zheng J, Bushman L, Meditz AL, Langness J, Fernandez C, Guida L, Rower J, Kiser J, and Anderson PL. Pharmacology of Tenofovir (TFV), Tenofovir-diphosphate (TFV-DP) and Emtricitabine (FTC) in Red Blood Cells (RBC) and/or Dried Blood Spots (DBS)" 19th Conference on Retroviruses and Opportunistic Infections, Seattle, March 5-8, 2012. Abstract # N-119
• Anderson PL, Kiser JJ, Gardner EM, Rower JE, Meditz AL, Grant RM. Pharmacologic Considerations for Tenofovir and Emtricitabine to Prevent HIV Infection. J. Antimicrob. Chemother. 2011; 66 (2): 240-250
• Meditz AL, Haas MK, Folkvord JM, Melander K, Young R, McCarter M, MaWhinney S, Campbell T, Lei Y, Coakley E, Levy DM, Connick E. HLA-DR+CD38+CD4+ T Lymphocytes Have Elevated CCR5 Expression and Produce the Majority of R5-tropic HIV-1 RNA in Vivo, J Virology 2011; 85(19):10189-10200
• Roberts JL, Kiser JJ, Hindman J, Meditz, AL. Case report. HIV-1 Treatment Failure on a Raltegravir-Containing Antiretroviral Regimen with Concomitant Administration of Calcium. Pharmacotherapy 2011; 31(10):298e-302e
• Meditz AL, MaWhinney S, Allshouse A, Feser W, Markowitz M, Little S, Hecht R, Daar E, Collier C, Margolick J, Kilby M, Routy J. Conway B, Kaldor J, Levy J, Schooley R, Cooper D, Altfeld M, Richman D, Connick E. Sex, Race and Geographic Region Influence Clinical Outcomes Following Primary HIV-1 Infection, J Infect Dis. 2011; 203(4):442-51
• Meditz AL, Haas M, Folkvord J, Melander K, Young R, McCarter M, Levy DN, Campbell, T, Connick E. Lymph Node HLA-DR+ CD3+ T cells are Preferred Targets of HIV-1 in vivo, but not in vitro. 17th Conference for Retroviruses and Opportunistic Infections 2010, Abstract #295
• Nguyan NH, Meditz AL, MaWhinney S, Folkvord J, McCarter M, Connick E. Lymph Node IFN-alpha is Related to Reduced Virus Producing Cells, But Does Not Explain Sex Differences in HIV-1 Infection. 17th Conference for Retroviruses and Opportunistic Infections 2010, Abstract #293
• Dillon S, Robertson K, Pan S, MaWhinney S, Meditz A, Folkvord J, Connick E, McCarter M, Wilson C. Activated Plasmacytoid and Myeloid Dendritic Cells Accumulate in Lymphoid Tissue during Asymptomatic, Chronic HIV Infection. 17th Conference for Retroviruses and Opportunistic Infections 2010, Abstract #479
• Meditz AL, MaWhinney S., Feser W, Markowitz M, Little S, Hecht R, Daar E, Collier C, Margolick J, Kilby M, Routy J. Conway B, Kaldor J, Levy J, Schooley R, Cooper D, Walker B, Richman D, Connick E. Sex and Race Influence Clinical Presentations and Outcomes Following Primary HIV-1 Infection, 17th Conference for Retroviruses and Opportunistic Infections 2010, Oral Presentation
• Mansoori L, Meditz A, Bergman C, Kohrt W, Moreau K. Tetrahydrobiopterin Decreases Large Artery Stiffening in Estrogen-Deficient Postmenopausal Women. Oral Presentation at Endocrine Society 92nd Annual Meeting & Expo, San Francisco CA June 10, 2010.
• Meditz AL, Moreau K, Melander K, Kohrt W, Wierman M, Connick E. CCR5 density on Activated CD4+ T cells, a Measure of HIV Susceptibility, is Higher in HIV-1 Seronegative Menopausal Compared to Reproductive-Aged Women. American Geriatrics Society 2010 Annual Scientific Meeting, Orlando FL
• Anderson PL, Kiser JJ, Gardner EM, Rower JE, Meditz AL, Grant RM. The relevance of tenofovir and emtricitabine cellular pharmacology for HIV prevention. Lancet Infectious Diseases. Submitted
• Meditz AL, Folkvord J, Haas M, Levy DN, McCarter M, Connick M, Activated T Cells Express Elevated Levels of HIV Co-receptors and Harbor High Levels of HIV RNA in Lymph Nodes. 16th Conference for Retroviruses and Opportunistic Infections 2009, Abstract #311
• Folkvord J, Meditz A, McCarter M, Connick M. The Follicular Homing Marker CXCR5 is Expressed by a Minority of Effector CD8+ Cells in HIV-1-Infected Lymph Nodes. 16th Conference for Retroviruses and Opportunistic Infections 2009, Abstract #373
• Allshouse AA; MaWhinney S; Feser W.; Meditz A.; Markowitz M.; Little S.; Hecht F.; Daar E.; Margolick J.; Kilby M.; Routy J.; Conway B.; Kaldor J.; Levy J.; Schooley R.; Cooper D.A.; Walker B.; Richman D.; Connick E.; A Two-stage Approach to Survival Analysis with Time Dependent Covariates from a Time Varying Means Model: Application of Time to Initiation of Therapy in HIV-infected Women vs. Men. Presented at the ASA JSM 2008, Denver, CO, August 2008
• Meditz AL, Wierman, ME, Connick, E The Impact of Hormonal Contraception on the HIV-1 Epidemic. European Infectious Diseases,2008; 2(1): 43-47.
• Meditz AL, Schlichtemeier R, Folkvord JM, Givens M, Lesh K, Ray MG, McCarter MD and Connick E. SDF-1a is a Potent Inducer of HIV-1-specific CD8+ T-cell Chemotaxis, but Migration of CD8+ T Cells is Impaired at High Viral Loads. AIDS Research and Human Retroviruses, 2008 Jul;24(7):977-85.
• Meditz, AL., Schlichtemeier R, Folkvord J, Givens, M, Lesh, K, Ray, MG, McCarter, MD, and Connick E. SDF-a is a potent inducer of HIV-1 specific CD8+ T-cell chemotaxis, but migration of CD8+ T cells is impaired at high viral loads. 15th Conference for Retroviruses and Opportunistic Infections, February 3-6, 2008.
• Dillon S, Robertson K, Pan S, MaWhinney S, Meditz A, Folkvord J, Connick E, McCarter M, Wilson, C. Activated plasmacytoid and myeloid dendritic cells accumulate in lymphoid tissue during asymptomatic, chronic HIV-1 infection. 15th Conference for Retroviruses and Opportunistic Infections, February 3-6, 2008.
• Meditz AL, Schlichtemeier R, Folkvord JM, Givens M, Lesh K, Ray MG, McCarter MD, and Connick E. SDF-1a is a Potent Inducer of HIV-1-specific CD8+ T-cell Chemotaxis, but Migration of CD8+ T Cells is Impaired at High Viral Loads. AIDS Research and Human Retroviruses, in press.
• Anderson P, Zheng JH, King T, Bushman LR, Predhomme J, Meditz AL, Gerber J, Fletcher C. Concentrations of Zidovudine- and Lamivudine-triphosphate according to cell-type in HIV-seronegative adults. AIDS. 2007 Sep;21(14):1849-54
• D’Souza M, Fontenot AP, Mack DG, Lozupone C, Dillon S, Meditz AL, Wilson CC, Connick E, Palmer BE.. PD-1 Expression on HIV-specific CD4+ T Cells is Driven by HIV Replication. J Immunol. 2007 Aug 1;179(3):1979-87.
• Dillon S, Robertson K, Pan S, MaWhinney S, Meditz AL, Folkvord J, Connick E, McCarter M, Wilson, C. Plasmacytoid and myeloid dendritic cells with a partial activation phenotype accumulate in lymphoid tissue during asymptomatic, chronic Human Immunodeficiency Virus Type 1 infection, JAIDS 2008 Jan 31
• Meditz AL, Borok M, Gudza I, Ndemera B, Gwanzura L and Campbell TB. Sex Differences in AIDS-associated Kaposi’s Sarcoma in Harare, Zimbabwe. JAIDS 2007 Mar 1;44(3):306-308
• Connick E, Mattila, T, Folkvord JM, Schlichtemeier R, Meditz, AL, McCarter M, MaWhinney S, Hage A, White C, and Skinner PJ. Cytotoxic T Cells Fail to Accumulate at Sites of HIV-1 Replication in Lymphoid Tissue. J Immunol, in press.
• Anderson P, Zheng JH, King T, Bushman LR, Predhomme J, Meditz AL, Gerber J, Fletcher C. Concentrations of Zidovudine- and Lamivudine-triphosphate according to cell-type in HIV-seronegative adults. JAIDS, in press.
• 1. Meditz AL, MaWhinney S., Feser W, Markowitz M, Little S, Hecht R, Daar E, Collier C, Margolick J, Kilby M, Routy J. Conway B, Kaldor J, Levy J, Schooley R, Cooper D, Walker B, Richman D, Connick E. Clinical features of primary HIV-1 infection in women. 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention, 2007, Sydney Australia
• Folkvord, J, McCarter M, Ryder J, Meditz AL, Forster JE, Connick E. Alpha-Defensins 1,2, and 3 are Expressed by Granulocytes in Lymph Nodes of HIV-1 Infected Individuals. JAIDS 2006 Aug 15; 42(5):529-536.

Practice Locations

Specialty Information

• Internal Medicine, Board Certification (2002)
• Infectious Disease, Board Certification (2005)

• Immune System - AIDS / HIV Disease
• Immune System - AIDS
• Infections - Sexually Transmitted Diseases
• Infections - Viral Infections
• Women's Health
• Immune System
• Infections