Lori Sussel, PhD

Publications

• Churchill AJ, Gutiérrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L. Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife. 2017 Jan 10;6. PubMed PMID: 28071588
• Gutiérrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L. Pancreatic ß cell identity requires continual repression of non-ß cell programs. J Clin Invest. 2017 Jan 3;127(1):244-259. PubMed PMID: 27941248
• Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ß cells. J Clin Invest. 2017 Jan 3;127(1):215-229. PubMed PMID: 27941246
• Gross S, Garofalo DC, Balderes DA, Mastracci TL, Dias JM, Perlmann T, Ericson J, Sussel L. The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2. Development. 2016 Jul 15;143(14):2616-28. PubMed PMID: 27287799
• Arnes L, Akerman I, Balderes DA, Ferrer J, Sussel L. ßlinc1 encodes a long noncoding RNA that regulates islet ß-cell formation and function. Genes Dev. 2016 Mar 1;30(5):502-7. PubMed PMID: 26944677
• Xuan S, Sussel L. GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling. Development. 2016 Mar 1;143(5):780-6. PubMed PMID: 26932670
• Borok MJ, Papaioannou VE, Sussel L. Unique functions of Gata4 in mouse liver induction and heart development. Dev Biol. 2016 Feb 15;410(2):213-22. PubMed PMID: 26687508
• Cui Y, Hu D, Markillie LM, Chrisler WB, Gaffrey MJ, Ansong C, Sussel L, Orr G. Fluctuation localization imaging-based fluorescence in situ hybridization (fliFISH) for accurate detection and counting of RNA copies in single cells. Nucleic Acids Res. 2017 Oct 4. [Epub ahead of print] PubMed PMID: 29040675
• Lorberbaum DS, Sussel L. Gotta Have GATA for Human Pancreas Development. Cell Stem Cell. 2017 May 4;20(5):577-579. PubMed PMID: 28475878
• Font-Cunill B, Arnes L, Ferrer J, Sussel L, Beucher A. Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes. Front Genet. 2018;9:524. PubMed PMID: 30459811
• Bartolome A, Zhu C, Sussel L, Pajvani UB. Notch signaling dynamically regulates adult ß cell proliferation and maturity. J Clin Invest. 2018 Oct 30. [Epub ahead of print] PubMed PMID: 30375986
• Singer RA, Sussel L. Islet Long Noncoding RNAs: A Playbook for Discovery and Characterization. Diabetes. 2018 Aug;67(8):1461-1470. PubMed PMID: 29937433
• Yin R, Kyle J, Burnum-Johnson K, Bloodsworth KJ, Sussel L, Ansong C, Laskin J. High Spatial Resolution Imaging of Mouse Pancreatic Islets Using Nanospray Desorption Electrospray Ionization Mass Spectrometry. Anal Chem. 2018 Jun 5;90(11):6548-6555. PubMed PMID: 29718662
• Arnes L, Liu Z, Wang J, Carlo Maurer H, Sagalovskiy I, Sanchez-Martin M, Bommakanti N, Garofalo DC, Balderes DA, Sussel L, Olive KP, Rabadan R. Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. Gut. 2018 Feb 10. [Epub ahead of print] PubMed PMID: 29440233
• Cui Y, Hu D, Markillie LM, Chrisler WB, Gaffrey MJ, Ansong C, Sussel L, Orr G. Fluctuation localization imaging-based fluorescence in situ hybridization (fliFISH) for accurate detection and counting of RNA copies in single cells. Nucleic Acids Res. 2018 Jan 25;46(2):e7. PubMed PMID: 29040675
• Gutierrez GD, Gromada J, Sussel L. Heterogeneity of the Pancreatic Beta Cell. Front Genet. 2017;8:22. PubMed PMID: 28321233
• Churchill AJ, Gutiérrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L. Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife. 2017 Jan 10;6. PubMed PMID: 28071588
• Gutiérrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L. Pancreatic ß cell identity requires continual repression of non-ß cell programs. J Clin Invest. 2017 Jan 3;127(1):244-259. PubMed PMID: 27941248
• Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ß cells. J Clin Invest. 2017 Jan 3;127(1):215-229. PubMed PMID: 27941246
• Singer RA, Arnes L, Cui Y, Wang J, Gao Y, Guney MA, Burnum-Johnson KE, Rabadan R, Ansong C, Orr G, Sussel L. The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function. Cell Metab. 2019 Oct 9. [Epub ahead of print] PubMed PMID: 31607563
• Romer AI, Singer RA, Sui L, Egli D, Sussel L. Murine Perinatal Beta Cell Proliferation and the Differentiation of Human Stem Cell Derived Insulin Expressing Cells Require NEUROD1. Diabetes. 2019 Sep 13. [Epub ahead of print] PubMed PMID: 31519700
• Hudish LI, Reusch JE, Sussel L. ß Cell dysfunction during progression of metabolic syndrome to type 2 diabetes. J Clin Invest. 2019 Oct 1;129(10):4001-4008. PubMed PMID: 31424428
• Hudish LI, Lorberbaum DS, Sussel L. FISHing for ß Cells. Dev Cell. 2019 Jan 7;48(1):7-8. PubMed PMID: 30620904
• Bartolome A, Zhu C, Sussel L, Pajvani UB. Notch signaling dynamically regulates adult ß cell proliferation and maturity. J Clin Invest. 2019 Jan 2;129(1):268-280. PubMed PMID: 30375986
• Moss ND, Sussel L. mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic ß Cell Function. Front Genet. 2020;11:983. PubMed PMID: 33088281
• Guney MA, Lorberbaum DS, Sussel L. Pancreatic ß cell regeneration: To ß or not to ß. Curr Opin Physiol. 2020 Apr;14:13-20. PubMed PMID: 32864533
• Pajvani UB, Sussel L. An Ultradian Notch in Beta-Cell Development. N Engl J Med. 2020 Jul 2;383(1):80-82. PubMed PMID: 32609988
• Lorberbaum DS, Kishore S, Rosselot C, Sarbaugh D, Brooks EP, Aragon E, Xuan S, Simon O, Ghosh D, Mendelsohn C, Gadue P, Sussel L. Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human ß cell specification. Development. 2020 Jun 22;147(12). PubMed PMID: 32467243
• Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Stem Cell Reports. 2020 Jun 9;14(6):1033-1043. PubMed PMID: 32386561
• Lorberbaum DS, Docherty FM, Sussel L. Animal Models of Pancreas Development, Developmental Disorders, and Disease. Adv Exp Med Biol. 2020;1236:65-85. PubMed PMID: 32304069
• Lorberbaum DS, Sussel L. A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development. Dev Cell. 2020 Mar 23;52(6):681-682. PubMed PMID: 32208161
• Singer RA, Arnes L, Cui Y, Wang J, Gao Y, Guney MA, Burnum-Johnson KE, Rabadan R, Ansong C, Orr G, Sussel L. The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function. Cell Metab. 2019 Dec 3;30(6):1091-1106.e8. PubMed PMID: 31607563
• Romer AI, Singer RA, Sui L, Egli D, Sussel L. Murine Perinatal ß-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1. Diabetes. 2019 Dec;68(12):2259-2271. PubMed PMID: 31519700
• David S. Lorberbaum, Fiona M. Docherty, Lori Sussel (2019). Animal Models of Human Birth Defects: Animal models of pancreas development, developmental disorders and disease. Springer Publishers, Book Chapter, in press.
• Michelle A. Guney, David S. Lorberbaum, and Lori Sussel (2019). Pancreatic ß cell regeneration: To ß or not to ß. Current Opinion in Physiology, in press.
• Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes Care. 2021 Aug;44(8):1744-1747. PubMed PMID: 34131046
• Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Stem Cell Reports. 2021 Apr 13;16(4):1009. PubMed PMID: 33852882
• Kim YK, Sussel L, Davidson HW. Inherent Beta Cell Dysfunction Contributes to Autoimmune Susceptibility. Biomolecules. 2021 Mar 30;11(4). PubMed PMID: 33808310
• Docherty FM, Sussel L. Islet Regeneration: Endogenous and Exogenous Approaches. Int J Mol Sci. 2021 Mar 24;22(7). PubMed PMID: 33804882
• Li F, Hu D, Dieter C, Ansong C, Sussel L, Orr G. Single Molecule-Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet ß-Cells. Diabetes. 2021 May;70(5):1117-1122. PubMed PMID: 33685924
• Theis A, Singer RA, Garofalo D, Paul A, Narayana A, Sussel L. Groucho co-repressor proteins regulate ß cell development and proliferation by repressing Foxa1 in the developing mouse pancreas. Development. 2021 Mar 24;148(6). PubMed PMID: 33658226
• Kim YK, Walters JA, Moss ND, Wells KL, Sheridan R, Miranda JG, Benninger RKP, Pyle LL, O'Brien RM, Sussel L, Davidson HW. Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration. Mol Metab. 2022 Nov 5;66:101632. [Epub ahead of print] PubMed PMID: 36347424
• Lorberbaum DS, Sarbaugh D, Sussel L. Leveraging the strengths of mice, human stem cells, and organoids to model pancreas development and diabetes. Front Endocrinol (Lausanne). 2022;13:1042611. PubMed PMID: 36339450
• Russ HA, Shilleh AH, Sussel L. From the dish to humans: A stem cell recipe for success. Cell Metab. 2022 Feb 1;34(2):193-196. PubMed PMID: 35108510
• Lori Sussel. Fetal and Neonatal Physiology Textbook; Chapter 85 Development of the Endocrine and Exocrine Pancreas
• E. Brooks and L. Sussel. Not the second fiddle: a cell identity and function in health and diabetes. Journal of Endocrinology
• Gemma L. Pearson; Emily M. Walker; Nathan Lawlor; Anne Lietzke; Vaibhav Sidarala; Jie Zhu; Tracy Stromer; Emma C. Reck; Jin Li; Aaron Renberg; Kawthar Mohamed; Vishal S. Parekh; Irina X. Zhang; Benjamin Thompson; Deqiang Zhang; Sarah A. Duplaga; Leena Haataja; Stephen C.J. Parker; Peter Arvan; Lei Yin; Brett A. Kaufman; Leslie S. Satin; Lori Sussel; Michael L. Stitzel; and Scott A. Soleimanpour. Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues. Cell Metabolism
• Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L. Major ß cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 Jun 1;37(11-12):490-504. PubMed PMID: 37364986
• Brooks EP, Sussel L. Not the second fiddle: a cell development, identity, and function in health and diabetes. J Endocrinol. 2023 Aug 1;258(2). PubMed PMID: 37171828
• Putman MS, Norris AW, Hull RL, Rickels MR, Sussel L, Blackman SM, Chan CL, Ode KL, Daley T, Stecenko AA, Moran A, Helmick MJ, Cray S, Alvarez JA, Stallings VA, Tuggle KL, Clancy JP, Eggerman TL, Engelhardt JF, Kelly A. Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes. Diabetes Care. 2023 Jun 1;46(6):1112-1123. PubMed PMID: 37125948
• Hansen MS, Pokharel P, Piganelli J, Sussel L. The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the ß Cell in Type 1 Diabetes. Cold Spring Harb Perspect Med. 2024 Jul 1. [Epub ahead of print] PubMed PMID: 38951031
• Haemmerle MW, Scota AV, Khosravifar M, Varney MJ, Sen S, Good AL, Yang X, Wells KL, Sussel L, Rozo AV, Doliba NM, Ghanem LR, Stoffers DA. RNA-binding protein PCBP2 regulates pancreatic ß cell function and adaptation to glucose. J Clin Invest. 2024 Jun 17;134(12). PubMed PMID: 38950317
• Kim YK, Won KC, Sussel L. Glucose metabolism partially regulates ß-cell function through epigenomic changes. J Diabetes Investig. 2024 Jun;15(6):649-655. PubMed PMID: 38436511
• Sarkar S, Deiter C, Kyle JE, Guney MA, Sarbaugh D, Yin R, Li X, Cui Y, Ramos-Rodriguez M, Nicora CD, Syed F, Juan-Mateu J, Muralidharan C, Pasquali L, Evans-Molina C, Eizirik DL, Webb-Robertson BM, Burnum-Johnson K, Orr G, Laskin J, Metz TO, Mirmira RG, Sussel L, Ansong C, Nakayasu ES. Regulation of ß-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis. Cell Commun Signal. 2024 Feb 21;22(1):141. PubMed PMID: 38383396
• Kim YK, Kim YR, Wells KL, Sarbaugh D, Guney M, Tsai CF, Zee T, Karsenty G, Nakayasu ES, Sussel L. PTPN2 Regulates Metabolic Flux to Affect ß-Cell Susceptibility to Inflammatory Stress. Diabetes. 2024 Mar 1;73(3):434-447. PubMed PMID: 38015772
• You Y, Sarkar S, Deiter C, Elliott EC, Nicora CD, Mirmira RG, Sussel L, Nakayasu ES. (2024) Reduction of chemokine CXCL9 expression by omega-3 fatty acids via ADP-ribosylhydrolase ARH3 in MIN6 insulin-producing cells. Proteomics, in press.
• Rotti, PG, Yi Y, Gasser G, Yuan F, Sun X, Apak-Evans I, Wu P, Liu G, Choi S, Reeves R, Scioneaux AE, Zhang Y, Winter M, Liang B, Cunicelli N, Uc A, Norris AW, Sussel L, Wells K, Engelhardt (2024) CFTR Represses a PDX1 Axis to Govern Pancreatic Ductal Cell Fate. iScience, in press.
• Brooks E, Casey M, Wells K, Liu T-Y, VanOrman M, and Sussel, L. 2024 NKX2.2 and KLF4 cooperate to regulate alpha cell identity. Genes and Development, in press.
• Putman MS, Norris AW, Hull RL, Rickels MR, Sussel L, Blackman SM, Chan CL, Ode KL, Daley T, Stecenko AA, Moran A, Helmick MJ, Cray S, Alvarez JA, Stallings VA, Tuggle KL, Clancy JP, Eggerman TL, Engelhardt JF, Kelly A. Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes. Diabetes. 2023 Jun 1;72(6):677-689. PubMed PMID: 37125945
• Kim, YK, Kim, RYK, Wells, KL, Guney, MA, Tsai, C-F, Zee, T, Karsenty, G, Nakayasu, ES and Sussel, L. (2023). PTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory stress. Diabetes, in press.
• Pearson, GL, Walker, EM, Lawlor, N, Lietzke, A, Sidarala, V, Zhu, J, Stromer, T, Reck, EC, Li, J, Renberg, A, Mohamed, K, Parekh, VS, Zhang, IX, Thompson, B, Zhang, D, Duplaga, SA, Haataja, L, Parker, SCJ, Arvan, P, Yin, L, Kaufman, B, Satin, LS, Sussel, L, Stitzel, ML and Soleimanpour, SA. (2023). Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues. Science. in re-review.
• Regulation of -cell death by ADP ribosylhydrolase ARH3 via lipid signaling in insulitis (2023). Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kvle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yins, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriquez, Carrie D. Nicora. Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorezo Pasquali, Carmella Evans-Molinas, Decio L. Eizirik, Bobbie-Jo M. Webb Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O. Metz, Raghavendra G. Mirmira, Lori Sussel, Charles Ansong, Ernesto Nakayasu. Cell Signaling and Communication, in press.
• Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L. Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nat Commun. 2023 Nov 25;14(1):7732. PubMed PMID: 38007492