Arthur Gutierrez-Hartmann, MD

Professional Titles

• Professor, Departments of Medicine and of Biochemistry & Molecular Genetics
• Director, Medical Scientist Training Program
• Director, Physician Scientist Training Program
• Associate Dean for Research Education

Publications

• Song KH, Trudeau T, Kar A, Borden MA, Gutierrez-Hartmann A. Ultrasound-mediated delivery of siESE complexed with microbubbles attenuates HER2 /- cell line proliferation and tumor growth in rodent models of breast cancer. Nanotheranostics. 2019;3(2):212-222. PubMed PMID: 31183315
• Roof AK, Trudeau T, Gutierrez-Hartmann A. Pituitary somatolactotropes evade an oncogenic response to Ras. Mol Cell Endocrinol. 2018 Nov 15;476:165-172. PubMed PMID: 29753028
• Roof AK, Jirawatnotai S, Trudeau T, Kuzyk C, Wierman ME, Kiyokawa H, Gutierrez-Hartmann A. The Balance of PI3K and ERK Signaling Is Dysregulated in Prolactinoma and Modulated by Dopamine. Endocrinology. 2018 Jun 1;159(6):2421-2434. PubMed PMID: 29726995
• Roof AK, Gutierrez-Hartmann A. Consider the context: Ras/ERK and PI3K/AKT/mTOR signaling outcomes are pituitary cell type-specific. Mol Cell Endocrinol. 2018 Mar 5;463:87-96. PubMed PMID: 28445712
• Roof AK, Gutierrez-Hartmann A. Consider the context: Ras/ERK and PI3K/AKT/mTOR signaling outcomes are pituitary cell type-specific. Mol Cell Endocrinol. 2018 Mar 5;463:87-96. PubMed PMID: 28445712
• Yeung TL, Leung CS, Wong KK, Gutierrez-Hartmann A, Kwong J, Gershenson DM, Mok SC. ELF3 is a negative regulator of epithelial-mesenchymal transition in ovarian cancer cells. Oncotarget. 2017 Mar 7;8(10):16951-16963. PubMed PMID: 28199976
• Kar A, Liu B, Gutierrez-Hartmann A. ESE-1 Knockdown Attenuates Growth in Trastuzumab-resistant HER2( ) Breast Cancer Cells. Anticancer Res. 2017 Dec;37(12):6583-6591. PubMed PMID: 29187433
• Kar A, Gutierrez-Hartmann A. ESE-1/ELF3 mRNA expression associates with poor survival outcomes in HER2( ) breast cancer patients and is critical for tumorigenesis in HER2( ) breast cancer cells. Oncotarget. 2017 Sep 19;8(41):69622-69640. PubMed PMID: 29050229
• Yeung TL, Leung CS, Wong KK, Gutierrez-Hartmann A, Kwong J, Gershenson DM, Mok SC. ELF3 is a negative regulator of epithelial-mesenchymal transition in ovarian cancer cells. Oncotarget. 2017 Feb 9. [Epub ahead of print] PubMed PMID: 28199976
• Song KH, Fan AC, Brlansky JT, Trudeau T, Gutierrez-Hartmann A, Calvisi ML, Borden MA. High Efficiency Molecular Delivery with Sequential Low-Energy Sonoporation Bursts. Theranostics. 2015;5(12):1419-27. PubMed PMID: 26681986
• Noetzli L, Lo RW, Lee-Sherick AB, Callaghan M, Noris P, Savoia A, Rajpurkar M, Jones K, Gowan K, Balduini CL, Pecci A, Gnan C, De Rocco D, Doubek M, Li L, Lu L, Leung R, Landolt-Marticorena C, Hunger S, Heller P, Gutierrez-Hartmann A, Xiayuan L, Pluthero FG, Rowley JW, Weyrich AS, Kahr WH, Porter CC, Di Paola J. Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat Genet. 2015 May;47(5):535-8. PubMed PMID: 25807284
• Booth AK, Gutierrez-Hartmann A. Signaling pathways regulating pituitary lactotrope homeostasis and tumorigenesis. Adv Exp Med Biol. 2015;846:37-59. PubMed PMID: 25472533
• Booth AK, Gutierrez-Hartmann A. Signaling pathways regulating pituitary lactotrope homeostasis and tumorigenesis. Adv Exp Med Biol. 2015;846:37-59. PubMed PMID: 25472533
• Booth A, Trudeau T, Gomez C, Lucia MS, Gutierrez-Hartmann A. Persistent ERK/MAPK activation promotes lactotrope differentiation and diminishes tumorigenic phenotype. Mol Endocrinol. 2014 Dec;28(12):1999-2011. PubMed PMID: 25361391
• Kar A, Gutierrez-Hartmann A. Molecular mechanisms of ETS transcription factor-mediated tumorigenesis. Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):522-43. PubMed PMID: 24066765
• Kar A and Gutierrez-Hartmann A. Molecular mechanisms of ETS transcription factor mediated tumorigenesis. Critical Reviews in Biochemistry and Molecular Biology 48: pending (2013)
• Kern HB, Niemeyer BF, Parrish JK, Kerr CA, Yaghi NK, Prescott JD, Gutierrez-Hartmann A, Jedlicka P. Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factors. DNA & Cell Bio 31:1403-11, 2012
• Kern HB, Niemeyer BF, Parrish JK, Kerr CA, Yaghi NK, Prescott JD, Gutierrez-Hartmann A, Jedlicka P. Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factors. DNA Cell Biol. 2012 Aug;31(8):1403-11. PubMed PMID: 22553926
• McConnell BV, Koto K, Gutierrez-Hartmann A. Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression. Mol Cancer 10:75, 2011. PMID: 21682918.
• Prescott JD, Poczobutt JM, Gonzales M, Gutierrez-Hartmann A. Mapping of ESE-1 subdomains required to initiate mammary epithelial cell transformation via a cytoplasmic mechanism. Molecular Cancer 10:103, 2011. PMID: 21871131.
• Tong Y, Zhou J, Mizutani J, Fukuoka H, Ren S-G, Gutierrez-Hartmann A, Koeffler HF, Melmed S. CEBPD suppresses prolactin expression and prolactinoma cell proliferation. Mol Endocrinol 25:1880-1891, 2011. PMID: 21980073
• Prescott JD, Poczobutt JM, Gonzales MS, Gutierrez-Hartmann A. Identification of a novel nuclear localization signal and nuclear export sequence that govern the cytoplasmic-dependent mammary epithelial cell transformation potency of Ese-1. Molecular Cancer, in revision
• McConnell BV, Koto K, Gutierrez-Hartmann A. Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression. Molecular Cancer, in revision
• Jean A, Gutierrez-Hartmann A, Duval DL. A Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit ras and estrogen stimulation of the prolactin gene promoter. Mol Endocrinol 24:91-103, 2010.
• Gutierrez-Hartmann, A. The Vanishing Physician-Scientist? J Clin Invest 120:1367, 2010
• Gutierrez-Hartmann, A. Minority Affairs: A remedy for a national ailment. ASBMB Today Newsletter, pp 22-23, December, 2010
• Poczobutt JM, Tentler JJ, Schedin PJ, Gutierrez-Hartmann A. Benign human mammary epithelial cells enhance the tumorigenic phenoype of breast cancer cells. BMC Cancer 16:373, 2010. PMID: 20637104
• Walker DM, Pozcobutt J, Gonzales MS, Horita H, Gutierrez-Hartmann A. ESE-1 is required to maintain the transformed phenotype of MCF-7 and ZR-75 human mammary epithelial cells. Open Cancer Journal 001:77-88, 2010. DOI: 10.2174/1874079001003010077.
• Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA. MicroRNAs Regulate Pituitary Development: MicroRNA 26b Directly Targets Lef-1. J Biol Chem 285:34718-28, 2010. PMID: 20807761.
• Walker DM, Pozcobutt J, Gonzales MS, Horita H, Gutierrez-Hartmann A. ESE-1 is required to maintain the transformed phenotype of MCF-7 and ZR-75 human mammary epithelial cells. Open Cancer Journal, in press, 2010.
• Review of "The Vanishing Physician-Scientist?" edited by Andrew I. Schafer. J Clin Invest 120 #5, 2010, in press.
• Poczobutt JM, Tentler JJ, Schedin PJ, Gutierrez-Hartmann A. Benign human mammary epithelial cells enhance the tumorigenic phenoype of breast cancer cells. BMC Cancer, in revision.
• Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA. MicroRNAs Regulate Pituitary Development: MicroRNA 26b Directly Targets Lef-1. J Biol Chem, Submitted.
• Poczobutt JM, Tentler JJ, Schedin PJ, Gutierrez-Hartmann A. Benign human mammary epithelial cells enhance the tumorigenic phenoype of breast cancer cells. BMC Cancer 10(1):373, 2010 PMID: 20637104
• Walker DM, Pozcobutt J, Gonzales MS, Horita H, Gutierrez-Hartmann A. ESE-1 is required to maintain the transformed phenotype of MCF-7 and ZR-75 human mammary epithelial cells. Open Cancer J 3:77-88, 2010. DOI: 10.2174/1874079001003010077
• Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA. MicroRNAs Regulate Pituitary Development: MicroRNA 26b Directly Targets Lef-1. J Biol Chem 285:34718-34728, 2010. PMID: 20807761
• Gutierrez-Hartmann, A. The Vanishing Physician-Scientist? J Clin Invest 120:1367, 2010.
• Gutierrez-Hartmann, A. Minority Affirs: A remedy for a national ailment. ASBMB Today Newsletter. pp 22-23, December, 2010. www.asbmb.org/asbmbtoday/asbmbtoday_article.aspx?id=10714
• Jedlicka P, Sui X, Sussel L, Gutierrez-Hartmann A. Epithelial ETS transcription factors regulate enterocyte maturation, epithelial migration and architectural organization of the small intestinal crypt-villus unit in the mouse. Am J Path 174:1280-1290, 2009.
• Jedlicka P, Sui X, Gutierrez-Hartmann A. The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice. BMC Cancer 9:197, 2009.
• Schweppe R, Kerege A, Sharma V, Poczobutt J, Gutierrez-Hartmann A, Grzywa R, Haugen B. Distinc Genetic Aletrations in the MAPK Pathway Dictate Sensitivity of Thyroid Cancer Cells to MKK1/2 Inhibition. Thyroid 19:825-835, 2009. PMID: 19500021 (Cover Article)
• Jonsen MD, Duval DL, Gutierrez-Hartmann A. The 26-amino acid ?-domain of the POU-homeodomain transcription factor Pit-1? is a novel, unique and independent interaction domain for a pituitary-specific co-repressor. Mol Endocrinol 23:1371-1384, 2009.
• Jean A, Gutierrez-Hartmann A, Duval DL. A Pit-1 threonine 220 phosphomimic reduces binding to monomeric sites to inhibit Ras and estrogen stimulation of the rat prolactin promoter. Mol Endocrinol 23: 91-103, 2009. PMID: 19887646
• Jedlicka P, Gutierrez-Hartmann A. ETS transcription factors and gastrointestinal epithelial cell biology. Histology & Histopath.
• Jedlicka P, Gutierrez-Hartmann A. ETS transcription factors and gastrointestinal epithelial cell biology. Histol Histopathol 23:1417-24, 2008.
• Duval DL, Diamond SE, Jonsen MD, Jean A, Murapa P, Gutierrez-Hartmann A. Differential utilization of transcription activation subdomains by distinct coactivators regulates Pit-1 basal and Ras responsiveness. J Biol Chem 21:172-185, 2007.
• Gutierrez-Hartmann A, Duval DL, Bradford AP. ETS transcription factors in endocrine systems. Trends Endocrinol Metabolism 18:150-158, 2007.
• Duval Dl, Jonsen MD, Diamond SE, Murapa P,Jean A, Gutierrez-Hartmann A. Differential utilization of trasncription activation subdomains by distinct coactivators regulates Pit-1 basal and Ras responsiveness. Mol Endocrinol. 21:172-185, 2006.
• Gutierrez-Hartmann A, Tudeau TY, Huss JA, Jonsen MD. Pit-1ß Stability is Regulated by Histone Deacetylase Activity. 88th Annual Meeting of the Endocrine Society, Boston, MA, June, 2006
• Gutierrez-Hartmann A, Tentler JJ. Pituitary Lactotroph-Targeted Expression of Dominant-Negative ETS Results in Decreased Lactotroph Cell Number and Serum PRL Levels in Transgenic Mice. 88th Annual Meeting of the Endocrine Society, Boston, MA, June, 2006
• Poczobutt J, Tentler JJ, Schedin P, Gutierrez-Hartmann A. Benign Mammary Epithelial Cells Confer Enhanced Proliferation Rate on Breast Cancer Cells in Nude Mice. Mammary Gland Gordon Research Conference, Il Ciocco, Italy, June, 2006.
• Tentler JJ, Gutierrez-Hartmann A. Pituitary Lactotroph-Targeted Expression of Dominant-Negative ETS Results in Decreased Lactotroph Cell Number in Transgenic Mice. Prolactin Family Gordon Research Conference, Ventura, CA, February, 2006
• Ferry AL, Locasto DM, Meszaros L, Bailey JC, Jonsen MD, Brodsky KS, Hoon CJ, Gutierrez-Hartmann A, Diamond SE. Pit-1ß reduces transcription and CBP recruitment in a DNA context-dependent manner. J Endocrinology 185:173-185, 2005
• Gutierrez-Hartmann A, Duval DL, Jonsen MD, Jean A, Cuaron JJ. Biological Functions of Pit-1ß: A Pituitary Specific Transcription Repressor that Diminishes Tumorigenic Growth of GH4 Somatolactotrope Cells. 87th Annual Meeting of the Endocrine Society, San Diego, CA, June, 2005
• Jirawatnotai S, Moons DS, Duval DL, Gutierrez-Hartmann A, Zou X, Kiyokawa H. G1-regulatory cyclin-Cdk complexes negatively modulate the Pit-1/Ets-dependent activity of the rat prolactin promoter. 87th Annual Meeting of the Endocrine Society, San Diego, CA, June, 2005
• Gutierrez-Hartmann A, Duval DL, Jonsen MD, Tentler JT, Jean A. The Role of Pit-1 and ETS Transcription Factors in Regulating Pituitary Lactotroph Biology and Prolactin Gene Expression. Argentina International Pituitary Conference, Iguazu, Argentina, November, 2005
• www.uchsc.edu/sm/mstp/recruitvideo.html
• Gutierrez-Hartmann A. ETS Transcription Factors in Pituitary Lactotroph Ontogeny & Gene Expression. 86th Annual Meeting of the Endocrine Society, New Orleans, LA, June, 2004. (Invited Plenary oral presentation)
• Prescott JD, Koto K, Singh M, Gutierrez-Hartmann A. The ETS transcription factor ESE-1 transforms MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Mol Cell Biol 24:5548-5564, 2004.
• Coletta RD, Jedlicka P, Gutierrez-Hartmann A, Ford HL. Transcriptional control of the cell cycle in mammary gland development and tumorigenesis. (Invited review). J Mamm Gland Biol 9:39-53, 2004
• Farrow KN, Bradford AP, Tentler JJ, Gutierrez-Hartmann A. Structural and functional analysis of the differential effects of c-Jun and v-Jun on prolactin gene. Mol Endocrinol 18:2479-2490, 2004
• Kern HB, Niemeyer BF, Parrish JK, Kerr CA, Yaghi N, Prescott JD, Gutierrez-Hartmann A, Jedlicka P. Control of microRNA-21 levels in colorectal cancer cells by ETS transcription factors and oncogenic EGF/Ras signaling. Submitted.

Professional Memberships

• Endocrine Society, Member
• American Society of Clinical Investigation, Selected member
• American Assocaition for Cancer Research, Member
• American Society of Biochemistry & Molecular Biology, Member
• Association of American Physicians, elected member

Practice Locations

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

UCHealth Diabetes and Endocrinology Clinic - Anschutz Medical Campus
1635 Aurora Ct
6th Floor
Aurora, CO 80045
720-848-2650

Hospital Affiliation

• University of Colorado Hospital

Center Affiliations

• University of Colorado Cancer Center
• Colorado Clinical & Translational Sciences Institute (CCTSI)

Specialty Information

Specialties

• Endocrinology, Diabetes and Metabolism, Board Certification (1985)

Conditions & Treatments

• Endocrine System (Hormones) - Endocrine Cancer (Parathyroid, Adrenal, Carcinoid)
• Endocrine System (Hormones) - Thyroid Cancer
• Endocrine System (Hormones) - Thyroid Disease
• Endocrine System (Hormones) - Adrenal Diseases
• Endocrine System (Hormones)