Aaron Michels, MD

Research Interests

Publications

• Herold KC, Gitelman SE, Willi SM, Gottlieb PA, Waldron-Lynch F, Devine L, Sherr J, Rosenthal SM, Adi S, Jalaludin MY, Michels AW, Dziura J, Bluestone JA. Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia. 2013 Feb;56(2):391-400. PubMed PMID: 23086558
• Beck RW, Tamborlane WV, Bergenstal RM, Miller KM, DuBose SN, Hall CA, T1D Exchange Clinic Network. The T1D Exchange clinic registry. J Clin Endocrinol Metab. 2012 Dec;97(12):4383-9. PubMed PMID: 22996145
• Yu L, Boulware DC, Beam CA, Hutton JC, Wenzlau JM, Greenbaum CJ, Bingley PJ, Krischer JP, Sosenko JM, Skyler JS, Eisenbarth GS, Mahon JL, Type 1 Diabetes TrialNet Study Group. Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies. Diabetes Care. 2012 Jun;35(6):1213-8. PubMed PMID: 22446173
• Piya A and Michels AW. Understanding the immunology of type 1 diabetes – an overview of current knowledge and perspectives for the future. US Endocrinology 2012; 8(1):70-74.
• Michels NM and Michels AW. Addison’s Disease: Early Detection, Treatment, and Management. American Family Physician 2013.
• Atkinson MA, Eisenbarth GS, and Michels AW. Type 1 diabetes – A season of change for concepts regarding the epidemiology, pathogenesis, treatment and prospects for disease attenuation. Lancet. 2013.
• Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2656-61. PubMed PMID: 24550292
• Gottlieb PA, Alkanani AK, Michels AW, Lewis EC, Shapiro L, Dinarello CA, Zipris D. Alpha(1)-Antitrypsin Therapy Downregulates Toll Like Receptor-Induced IL-1ß Responses in Monocytes and Myeloid Dendritic Cells and may Improve Islet Function in Recently Diagnosed Patients with Type 1 Diabetes. J Clin Endocrinol Metab. 2014 Feb 14;:jc20133864. [Epub ahead of print] PubMed PMID: 24527714
• Gottlieb PA, Delong T, Baker RL, Fitzgerald-Miller L, Wagner R, Cook G, Rewers MR, Michels A, Haskins K. Chromogranin A is a T cell antigen in human type 1 diabetes. J Autoimmun. 2013 Nov 12. [Epub ahead of print] PubMed PMID: 24239002
• Garg SK, Michels AW, Shah VN. Use of non-insulin therapies for type 1 diabetes. Diabetes Technol Ther. 2013 Nov;15(11):901-8. PubMed PMID: 24131372
• Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014 Jan 4;383(9911):69-82. PubMed PMID: 23890997
• Michels AW. Targeting the trimolecular complex: the pathway towards type 1 diabetes prevention. Diabetes Technol Ther. 2013 Jun;15 Suppl 2:S2-8-S2-12. PubMed PMID: 23786298
• Michels AW. Targeting the trimolecular complex. Clin Immunol. 2013 Dec;149(3):339-44. PubMed PMID: 23537861
• Herold KC, Gitelman SE, Willi SM, Gottlieb PA, Waldron-Lynch F, Devine L, Sherr J, Rosenthal SM, Adi S, Jalaludin MY, Michels AW, Dziura J, Bluestone JA. Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia. 2013 Feb;56(2):391-400. PubMed PMID: 23086558
• Weinstock RS, Xing D, Maahs DM, Michels A, Rickels MR, Peters AL, Bergenstal RM, Harris B, Dubose SN, Miller KM, Beck RW, T1D Exchange Clinic Network. Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry. J Clin Endocrinol Metab. 2013 Aug;98(8):3411-9. PubMed PMID: 23760624
• Michels A, Michels N. Addison disease: early detection and treatment principles. Am Fam Physician. 2014 Apr 1;89(7):563-8. PubMed PMID: 24695602
• Liu E, McDaniel K, Case S, Yu L, Gerhartz B, Ostermann N, Fankhauser G, Hungerford V, Zou C, Luyten M, Seidl KJ, Michels AW. Exploring T cell reactivity to gliadin in young children with newly diagnosed celiac disease. Autoimmune Dis. 2014;2014:927190. PubMed PMID: 24724018
• Aydintug MK, Zhang L, Wang C, Liang D, Wands JM, Michels AW, Hirsch B, Day BJ, Zhang G, Sun D, Eisenbarth GS, O'Brien RL, Born WK. ?d T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation. Mol Immunol. 2014 Aug;60(2):116-28. PubMed PMID: 24853397
• Maturu A, Michels A, Draznin B. Multiple Disease Associations in Autoimmune Polyglandular Syndrome Type II. Endocr Pract. 2014 Dec 1;20(12):e250-5. PubMed PMID: 25148815
• Simmons K, Michels AW. Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease. Rheum Dis Clin North Am. 2014 Nov;40(4):797-811. PubMed PMID: 25437293
• Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Rosenthal SM, Shuster JJ, Zou B, Brusko TM, Hulme MA, Wasserfall CH, Mathews CE, Atkinson MA, Schatz DA. Anti-thymocyte globulin/G-CSF treatment preserves ß cell function in patients with established type 1 diabetes. J Clin Invest. 2015 Jan;125(1):448-55. PubMed PMID: 25500887
• Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2656-61. PubMed PMID: 24550292
• Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014 Jan 4;383(9911):69-82. PubMed PMID: 23890997
• Gottlieb PA, Delong T, Baker RL, Fitzgerald-Miller L, Wagner R, Cook G, Rewers MR, Michels A, Haskins K. Chromogranin A is a T cell antigen in human type 1 diabetes. J Autoimmun. 2014 May;50:38-41. PubMed PMID: 24239002
• Gottlieb PA, Alkanani AK, Michels AW, Lewis EC, Shapiro L, Dinarello CA, Zipris D. a1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1ß responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes. J Clin Endocrinol Metab. 2014 Aug;99(8):E1418-26. PubMed PMID: 24527714
• Simmons KM, Michels AW. Alternate Ways to Quantify Antibodies. Diabetes Technol Ther. 2015 Dec;17(12):854-6. PubMed PMID: 26544921
• Michels AW, Ostrov DA. New approaches for predicting T cell-mediated drug reactions: A role for inducible and potentially preventable autoimmunity. J Allergy Clin Immunol. 2015 Aug;136(2):252-7. PubMed PMID: 26254052
• Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, Pietropaolo M. Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. Pediatr Diabetes. 2015 Nov;16(7):465-84. PubMed PMID: 26202050
• Michels A, Gottlieb P. Pathogenesis of Type 1A Diabetes. 2015. PubMed PMID: 25905233
• Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. Islet-derived CD4 T-cells targeting proinsulin in human autoimmune diabetes. Diabetes. 2016 Dec 5. [Epub ahead of print] PubMed PMID: 27920090
• Simmons KM, Michels AW. Type 1 diabetes: A predictable disease. World J Diabetes. 2015 Apr 15;6(3):380-90. PubMed PMID: 25897349
• Simmons KM, Alkanani AK, McDaniel KA, Goyne C, Miao D, Zhao Z, Yu L, Michels AW. Islet Autoantibody Measurements from Dried Blood Spots on Filter Paper Strongly Correlate to Serum Levels. PLoS One. 2016 Nov 15;11(11):e0166213. PubMed PMID: 27846247
• Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Perry DJ, Schultz AR, Hulme MA, Shuster JJ, Zou B, Wasserfall CH, Posgai AL, Mathews CE, Brusko TM, Atkinson MA, Schatz DA. Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes. Diabetes. 2016 Dec;65(12):3765-3775. PubMed PMID: 27669730
• Simmons KM, Gottlieb PA, Michels AW. Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes. Curr Diab Rep. 2016 Oct;16(10):97. PubMed PMID: 27558810
• Fouts A, Pyle L, Yu L, Miao D, Michels A, Krischer J, Sosenko J, Gottlieb P, Steck AK. Do Electrochemiluminescence Assays Improve Prediction of Time to Type 1 Diabetes in Autoantibody-Positive TrialNet Subjects?. Diabetes Care. 2016 Oct;39(10):1738-44. PubMed PMID: 27456836
• Wasserfall C, Montgomery E, Yu L, Michels A, Gianani R, Pugliese A, Nierras C, Kaddis JS, Schatz DA, Bonifacio E, Atkinson MA. Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease. Clin Exp Immunol. 2016 Jul;185(1):33-41. PubMed PMID: 27029857
• Zhao Z, Miao D, Michels A, Steck A, Dong F, Rewers M, Yu L. A multiplex assay combining insulin, GAD, IA-2 and transglutaminase autoantibodies to facilitate screening for pre-type 1 diabetes and celiac disease. J Immunol Methods. 2016 Mar;430:28-32. PubMed PMID: 26809048
• Saxon DR, McDermott MT, Michels AW. Novel Management of Insulin Autoimmune Syndrome with Rituximab and Continuous Glucose Monitoring. J Clin Endocrinol Metab. 2016 May;101(5):1931-4. PubMed PMID: 26982011
• Nakayama M, McDaniel K, Fitzgerald-Miller L, Kiekhaefer C, Snell-Bergeon JK, Davidson HW, Rewers M, Yu L, Gottlieb P, Kappler JW, Michels A. Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4429-34. PubMed PMID: 25831495
• Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Rosenthal SM, Shuster JJ, Zou B, Brusko TM, Hulme MA, Wasserfall CH, Mathews CE, Atkinson MA, Schatz DA. Anti-thymocyte globulin/G-CSF treatment preserves ß cell function in patients with established type 1 diabetes. J Clin Invest. 2015 Jan;125(1):448-55. PubMed PMID: 25500887
• Nakayama M, Simmons KM, Michels AW. Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes. Curr Diab Rep. 2015 Dec;15(12):113. PubMed PMID: 26458384
• Yeh WI, Seay HR, Newby B, Posgai AL, Moniz FB, Michels A, Mathews CE, Bluestone JA, Brusko TM. Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes. Front Immunol. 2017;8:1313. PubMed PMID: 29123516
• Redondo MJ, Geyer S, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth J, Xu P, Pugliese A. TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes. Diabetes Care. 2017 Oct 12. [Epub ahead of print] PubMed PMID: 29025879
• Kent SC, Mannering SI, Michels AW, Babon JAB. Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime". Curr Diab Rep. 2017 Sep 2;17(10):95. PubMed PMID: 28864875
• Spanier JA, Sahli NL, Wilson JC, Martinov T, Dileepan T, Burrack AL, Finger EB, Blazar BR, Michels AW, Moran A, Jenkins MK, Fife BT. Increased Effector Memory Insulin-Specific CD4( ) T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes. Diabetes. 2017 Dec;66(12):3051-3060. PubMed PMID: 28842400
• Waugh K, Snell-Bergeon J, Michels A, Dong F, Steck AK, Frohnert BI, Norris JM, Rewers M. Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY). PLoS One. 2017;12(4):e0174840. PubMed PMID: 28380011
• Acevedo-Calado M, James EA, Morran MP, Pietropaolo SL, Ouyang Q, Arribas-Layton D, Songini M, Liguori M, Casu A, Auchus RJ, Huang S, Yu L, Michels A, Gianani R, Pietropaolo M. Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development. Diabetes Care. 2017 Apr;40(4):561-568. PubMed PMID: 28174261
• Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes. Diabetes. 2017 Mar;66(3):722-734. PubMed PMID: 27920090
• Simmons KM, Alkanani AK, McDaniel KA, Goyne C, Miao D, Zhao Z, Yu L, Michels AW. Islet Autoantibody Measurements from Dried Blood Spots on Filter Paper Strongly Correlate to Serum Levels. PLoS One. 2016;11(11):e0166213. PubMed PMID: 27846247
• Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Perry DJ, Schultz AR, Hulme MA, Shuster JJ, Zou B, Wasserfall CH, Posgai AL, Mathews CE, Brusko TM, Atkinson MA, Schatz DA. Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes. Diabetes. 2016 Dec;65(12):3765-3775. PubMed PMID: 27669730
• Redondo MJ, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth JM, Atkinson MA, Pugliese A, Geyer S. Transcription Factor 7-Like 2 ( TCF7L2 ) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes. Diabetes Care. 2018 Dec;41(12):2480-2486. PubMed PMID: 30275285
• Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 Nov;462:65-73. PubMed PMID: 30165064
• Akturk HK, Alkanani A, Zhao Z, Yu L, Michels AW. PD-1 Inhibitor Immune-Related Adverse Events in Patients With Preexisting Endocrine Autoimmunity. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3589-3592. PubMed PMID: 30124874
• Michels AW, Gottlieb PA. Learning From Past Failures of Oral Insulin Trials. Diabetes. 2018 Jul;67(7):1211-1215. PubMed PMID: 29934364
• Castro-Gutierrez R, Michels AW, Russ HA. ß Cell replacement: improving on the design. Curr Opin Endocrinol Diabetes Obes. 2018 Aug;25(4):251-257. PubMed PMID: 29846237
• Akturk HK, Michels AW. Adverse Events Associated with Immune Checkpoint Blockade. N Engl J Med. 2018 Mar 22;378(12):1163-4. PubMed PMID: 29565519
• Ostrov DA, Alkanani A, McDaniel KA, Case S, Baschal EE, Pyle L, Ellis S, Pöllinger B, Seidl KJ, Shah VN, Garg SK, Atkinson MA, Gottlieb PA, Michels AW. Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. J Clin Invest. 2018 May 1;128(5):1888-1902. PubMed PMID: 29438107
• Yeh WI, Seay HR, Newby B, Posgai AL, Moniz FB, Michels A, Mathews CE, Bluestone JA, Brusko TM. Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes. Front Immunol. 2017;8:1313. PubMed PMID: 29123516
• Redondo MJ, Geyer S, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth J, Xu P, Pugliese A. TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes. Diabetes Care. 2018 Feb;41(2):311-317. PubMed PMID: 29025879
• Spanier JA, Sahli NL, Wilson JC, Martinov T, Dileepan T, Burrack AL, Finger EB, Blazar BR, Michels AW, Moran A, Jenkins MK, Fife BT. Increased Effector Memory Insulin-Specific CD4( ) T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes. Diabetes. 2017 Dec;66(12):3051-3060. PubMed PMID: 28842400
• Kent SC, Mannering SI, Michels AW, Babon JAB. Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime". Curr Diab Rep. 2017 Sep 2;17(10):95. PubMed PMID: 28864875
• Gu Y, Zhao Z, Waugh K, Miao D, Jia X, Cheng J, Michels A, Rewers M, Yang T, Yu L. High-throughput multiplexed autoantibody detection to screen type 1 diabetes and multiple autoimmune diseases simultaneously. EBioMedicine. 2019 Sep;47:365-372. PubMed PMID: 31447394
• Pan RY, Chu MT, Wang CW, Lee YS, Lemonnier F, Michels AW, Schutte R, Ostrov DA, Chen CB, Phillips EJ, Mallal SA, Mockenhaupt M, Bellón T, Tassaneeyakul W, White KD, Roujeau JC, Chung WH, Hung SI. Identification of drug-specific public TCR driving severe cutaneous adverse reactions. Nat Commun. 2019 Aug 8;10(1):3569. PubMed PMID: 31395875
• Simmons KM, Youngkin E, Alkanani A, Miao D, McDaniel K, Yu L, Michels AW. Screening children for type 1 diabetes-associated antibodies at community health fairs. Pediatr Diabetes. 2019 Nov;20(7):909-914. PubMed PMID: 31376227
• Akturk HK, Kahramangil D, Sarwal A, Hoffecker L, Murad MH, Michels AW. Immune checkpoint inhibitor-induced Type 1 diabetes: a systematic review and meta-analysis. Diabet Med. 2019 Sep;36(9):1075-1081. PubMed PMID: 31199005
• Baker RL, Rihanek M, Hohenstein AC, Nakayama M, Michels A, Gottlieb PA, Haskins K, Delong T. Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes. Diabetes. 2019 Sep;68(9):1830-1840. PubMed PMID: 31175101
• Acevedo-Calado MJ, Pietropaolo SL, Morran MP, Schnell S, Vonberg AD, Verge CF, Gianani R, Becker DJ, Huang S, Greenbaum CJ, Yu L, Davidson HW, Michels AW, Rich SS, Pietropaolo M. Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes. Diabetes. 2019 Sep;68(9):1819-1829. PubMed PMID: 31167877
• Ahmed R, Omidian Z, Giwa A, Cornwell B, Majety N, Bell DR, Lee S, Zhang H, Michels A, Desiderio S, Sadegh-Nasseri S, Rabb H, Gritsch S, Suva ML, Cahan P, Zhou R, Jie C, Donner T, Hamad ARA. A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen. Cell. 2019 May 30;177(6):1583-1599.e16. PubMed PMID: 31150624
• Nakayama M, Michels AW. Determining Antigen Specificity of Human Islet Infiltrating T Cells in Type 1 Diabetes. Front Immunol. 2019;10:365. PubMed PMID: 30906293
• Ostrov DA, Gottlieb PA, Michels AW. Rationally designed small molecules to prevent type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2019 Apr;26(2):90-95. PubMed PMID: 30694829
• Akturk HK, Michels AW. Adverse Events Associated With Immune Checkpoint Inhibitors. JAMA. 2019 Mar 26;321(12):1219. PubMed PMID: 30912828
• Anderson AM, Landry LG, Alkanani AA, Pyle L, Powers AC, Atkinson MA, Mathews CE, Roep BO, Michels AW, Nakayama M. Human islet T cells are highly reactive to preproinsulin in type 1 diabetes. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41). PubMed PMID: 34611019
• Gottlieb PA, Michels AW. Advances in Diabetes Treatment - Once-Weekly Insulin. N Engl J Med. 2020 Nov 26;383(22):2171-2172. PubMed PMID: 33252874
• Castro-Gutierrez R, Alkanani A, Mathews CE, Michels A, Russ HA. Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition. Front Endocrinol (Lausanne). 2021;12:707881. PubMed PMID: 34305820
• Landry LG, Anderson AM, Russ HA, Yu L, Kent SC, Atkinson MA, Mathews CE, Michels AW, Nakayama M. Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors. Front Endocrinol (Lausanne). 2021;12:622647. PubMed PMID: 33841327
• Akturk HK, Michels AW. Adverse events associated with immune checkpoint inhibitors: a new era in autoimmune diabetes. Curr Opin Endocrinol Diabetes Obes. 2020 Aug;27(4):187-193. PubMed PMID: 32618630
• Simmons KM, Mitchell AM, Alkanani AA, McDaniel KA, Baschal EE, Armstrong T, Pyle L, Yu L, Michels AW. Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02 . Diabetes. 2020 Aug;69(8):1763-1769. PubMed PMID: 32439825
• Akturk HK, Michels AW. Immune Checkpoint Inhibitor-Induced Type 1 Diabetes: An Underestimated Risk. Mayo Clin Proc. 2020 Mar;95(3):614-615. PubMed PMID: 32138890
• Gu Y, Zhao Z, Waugh K, Miao D, Jia X, Cheng J, Michels A, Rewers M, Yang T, Yu L. High-throughput multiplexed autoantibody detection to screen type 1 diabetes and multiple autoimmune diseases simultaneously. EBioMedicine. 2019 Sep;47:365-372. PubMed PMID: 31447394
• Simmons KM, Youngkin E, Alkanani A, Miao D, McDaniel K, Yu L, Michels AW. Screening children for type 1 diabetes-associated antibodies at community health fairs. Pediatr Diabetes. 2019 Nov;20(7):909-914. PubMed PMID: 31376227
• Jia X, Gesualdo P, Geno Rasmussen C, Alkanani AA, He L, Dong F, Rewers MJ, Michels AW, Yu L. Prevalence of SARS-CoV-2 Antibodies in Children and Adults with Type 1 Diabetes. Diabetes Technol Ther. 2021 Jul;23(7):517-521. PubMed PMID: 33544017
• Mitchell AM, Alkanani AA, McDaniel KA, Pyle L, Waugh K, Steck AK, Nakayama M, Yu L, Gottlieb PA, Rewers MJ, Michels AW. T-cell responses to hybrid insulin peptides prior to type 1 diabetes development. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6). PubMed PMID: 33542101
• Mitchell AM, Michels AW. T cell receptor sequencing in autoimmunity. J Life Sci (Westlake Village). 2020 Dec;2(4):38-58. PubMed PMID: 33364626
• Akturk HK, Kahramangil D, Sarwal A, Hoffecker L, Murad MH, Michels AW. Immune checkpoint inhibitor-induced Type 1 diabetes: a systematic review and meta-analysis. Diabet Med. 2019 Sep;36(9):1075-1081. PubMed PMID: 31199005
• Gottlieb PA, Michels AW. Advances in Diabetes Treatment - Once-Weekly Insulin. N Engl J Med. 2020 Nov 26;383(22):2171-2172. PubMed PMID: 33252874
• Baker RL, Rihanek M, Hohenstein AC, Nakayama M, Michels A, Gottlieb PA, Haskins K, Delong T. Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes. Diabetes. 2019 Sep;68(9):1830-1840. PubMed PMID: 31175101
• Akturk HK, Michels AW. Adverse events associated with immune checkpoint inhibitors: a new era in autoimmune diabetes. Curr Opin Endocrinol Diabetes Obes. 2020 Aug;27(4):187-193. PubMed PMID: 32618630
• Akturk HK, Michels AW. Immune Checkpoint Inhibitor-Induced Type 1 Diabetes: An Underestimated Risk. Mayo Clin Proc. 2020 Mar;95(3):614-615. PubMed PMID: 32138890
• Mann SE, Zhou Z, Landry LG, Anderson AM, Alkanani AK, Fischer J, Peakman M, Mallone R, Campbell K, Michels AW, Nakayama M. Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System. Front Immunol. 2020;11:633. PubMed PMID: 32328071
• Simmons KM, Mitchell AM, Alkanani AA, McDaniel KA, Baschal EE, Armstrong T, Pyle L, Yu L, Michels AW. Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02 . Diabetes. 2020 Aug;69(8):1763-1769. PubMed PMID: 32439825
• Acevedo-Calado MJ, Pietropaolo SL, Morran MP, Schnell S, Vonberg AD, Verge CF, Gianani R, Becker DJ, Huang S, Greenbaum CJ, Yu L, Davidson HW, Michels AW, Rich SS, Pietropaolo M. Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes. Diabetes. 2019 Sep;68(9):1819-1829. PubMed PMID: 31167877
• Mitchell AM, Baschal EE, McDaniel KA, Simmons KM, Pyle L, Waugh K, Steck AK, Yu L, Gottlieb PA, Rewers MJ, Nakayama M, Michels AW. Temporal development of T cell receptor repertoires during childhood in health and disease. JCI Insight. 2022 Sep 22;7(18). PubMed PMID: 35998036
• Mitchell AM, Michels AW. Self-Antigens Targeted by Regulatory T Cells in Type 1 Diabetes. Int J Mol Sci. 2022 Mar 15;23(6). PubMed PMID: 35328581
• Michels AW, Redondo MJ, Atkinson MA. The pathogenesis, natural history, and treatment of type 1 diabetes: time (thankfully) does not stand still. Lancet Diabetes Endocrinol. 2022 Feb;10(2):90-92. PubMed PMID: 34951951
• Nakayama M, Michels AW. Using the T Cell Receptor as a Biomarker in Type 1 Diabetes. Front Immunol. 2021;12:777788. PubMed PMID: 34868047
• Anderson AM, Landry LG, Alkanani AA, Pyle L, Powers AC, Atkinson MA, Mathews CE, Roep BO, Michels AW, Nakayama M. Human islet T cells are highly reactive to preproinsulin in type 1 diabetes. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41). PubMed PMID: 34611019
• Castro-Gutierrez R, Alkanani A, Mathews CE, Michels A, Russ HA. Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition. Front Endocrinol (Lausanne). 2021;12:707881. PubMed PMID: 34305820
• Wenzlau JM, Gu Y, Michels A, Rewers M, Haskins K, Yu L. Identification of Autoantibodies to a Hybrid Insulin Peptide in Type 1 Diabetes. Diagnostics (Basel). 2023 Sep 4;13(17). PubMed PMID: 37685398
• Jia X, Dong F, Pyle L, Michels AW, Yu L, Rewers M. Similar Time Course of Humoral Response to SARS-CoV-2 mRNA Vaccines in People With and Without Type 1 Diabetes. Diabetes Technol Ther. 2023 Jul;25(7):492-496. PubMed PMID: 36989496
• Akturk HK, Couts KL, Baschal EE, Karakus KE, Van Gulick RJ, Turner JA, Pyle L, Robinson WA, Michels AW. Analysis of Human Leukocyte Antigen DR Alleles, Immune-Related Adverse Events, and Survival Associated With Immune Checkpoint Inhibitor Use Among Patients With Advanced Malignant Melanoma. JAMA Netw Open. 2022 Dec 1;5(12):e2246400. PubMed PMID: 36512357
• Triolo TM, Matuschek JQ, Castro-Gutierrez R, Shilleh AH, Williams SPM, Hansen MS, McDaniel K, Barra JM, Michels A, Russ HA. Stem-Cell-Derived ß-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity. Cells. 2022 Nov 30;11(23). PubMed PMID: 36497105
• Mitchell AM, Baschal EE, McDaniel KA, Simmons KM, Pyle L, Waugh K, Steck AK, Yu L, Gottlieb PA, Rewers MJ, Nakayama M, Michels AW. Temporal development of T cell receptor repertoires during childhood in health and disease. JCI Insight. 2022 Sep 22;7(18). PubMed PMID: 35998036
• Mitchell AM, Michels AW. Self-Antigens Targeted by Regulatory T Cells in Type 1 Diabetes. Int J Mol Sci. 2022 Mar 15;23(6). PubMed PMID: 35328581
• Michels AW, Redondo MJ, Atkinson MA. The pathogenesis, natural history, and treatment of type 1 diabetes: time (thankfully) does not stand still. Lancet Diabetes Endocrinol. 2022 Feb;10(2):90-92. PubMed PMID: 34951951
• Mandel-Brehm C, Vazquez SE, Liverman C, Cheng M, Quandt Z, Kung AF, Parent A, Miao B, Disse E, Cugnet-Anceau C, Dalle S, Orlova E, Frolova E, Alba D, Michels A, Oftedal BE, Lionakis MS, Husebye ES, Agarwal AK, Li X, Zhu C, Li Q, Oral E, Brown R, Anderson MS, Garg A, DeRisi JL. Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy. Diabetes. 2023 Jan 1;72(1):59-70. PubMed PMID: 35709010

Professional Memberships

• American Diabetes Association, Member
• Endocrine Society, Member
• American College of Clinical Endocrinologists, Member

Practice Locations

• Children's Hospital Colorado
• University of Colorado Hospital

• Barbara Davis Center for Childhood Diabetes

Specialty Information

• Internal Medicine, Board Certification (2007)
• Endocrinology, Diabetes and Metabolism, Board Certification (2009)

• Endocrine System (Hormones) - Adult Type 1 Diabetes
• Endocrine System (Hormones) - Adult Type 2 Diabetes
• Child and Teen Health - Juvenile Diabetes
• Child and Teen Health
• Endocrine System (Hormones)