Frederick Suchy, MD
Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition

Professional Titles

• Chief Research Officer, Digestive Health

Recognition & Awards

• America's Best Doctors, Castlle Connolly (2016)
  also awarded 2005-2010
• member, Association of American Physicians (2002)
• Member, American Society for Clinical Investigation (1992)

Research Interests

Teaching

Publications

• El Kasmi KC , Ghosh S , Anderson AE ,Devereaux MW, Balasubramaniyan N , D’Alessandro A , Orlicky DJ , Suchy FJ , Shearn CT , Sokol RJ: Pharmacologic activation of FXR Prevents Parenteral Nutrition Associated Cholestasis in Mice. Hepatology 75(2):252-265, 2022.
• El Kasmi KC, Anderson AI, Devereaux MW, Balasubramaniyan N, Suchy FJ ,Orlicky DJ, Shearn CT, Sokol RJ : Interrupting Tumor Necrosis Factor-alpha Signaling Prevents Parenteral Nutrition Associated Cholestasis in Mice. J Parenter Enteral Nutr, 46(5):1096-1106. 2022
• Antonia Felzen1, Daan B.E. van Wessel1 ,Emmanuel Gonzales2,3, Richard J. Thompson4, Irena Jankowska3,5, Benjamin L. Shneider6,7, Etienne Sokal3,8, Tassos Grammatikopoulos4, Agustina Kadaristiana4, Emmanuel Jacquemin2,9, Anne Spraul9,10, Patryk Lipinski3,5, Piotr Czubkowski3,5, Nathalie Rock8, Mohammad Shagrani11,12, Dieter Broering11, Talal Algoufi11, Nejat Mazhar11, Emanuele Nicastro13, Deirdre Kelly3,14, Gabriella Nebbia15, Henrik Arnell3,16, Björn Fischler3,16, Jan B.F. Hulscher3,17, Daniele Serranti18, Cigdem Arikan19, Esra Polat20, Dominique Debray3,21, Florence Lacaille3,21, Cristina Goncalves3,22, Loreto Hierro3,23, Gema Muñoz Bartolo3,23, Yael Mozer-Glassberg24, Amer Azaz25, Jernej Brecelj26,27, Antal Dezsofi28, Pier Luigi Calvo29, Enke Grabhorn30, Steffen Hartleif3,31, Wendy J. van der Woerd32, Binita M. Kamath7,33, Jian-She Wang34, Liting Li34, Özlem Durmaz35, Nanda Kerkar36, Marianne Hørby Jørgensen3,37, Ryan Fischer38, Carolina Jimenez-Rivera39, Seema Alam40, Mara Cananzi3,41, Mathias Ruiz3,42, Cristina Targa Ferreira43, Felipe Ordoñez44, Heng Wang45, Valerie Sency45, Kyung Mo Kim46, Huey-Ling Chen47, Elisa Carvalho48, Alexandre Fabre49,50, Jesus Quintero Bernabeu3,51, Estella M. Alonso7,52, Ronald J. Sokol7,53, Frederick J. Suchy7,54, Kathleen M. Loomes7,55, Patrick J. McKiernan7,56, Philip Rosenthal7,57, Yumirle Turmelle7,58, Simon Horslen7,59, Kathleen Schwarz7,60, Jorge A. Bezerra7,61, Kasper Wang7,62, Bettina E. Hansen63,64, Henkjan J. Verkade1,3, and the NAtural course and Prognosis of PFIC and Effect of biliary Diversion (NAPPED) Consortium: Genotype-phenotype relationships of p.E297G, p.D482G and predicted protein truncating mutations in bile salt export pump deficiency. JHEP Reports (In Press)
• Suchy FJ: The Environment and Liver Disease in Children, in Textbook of Environmental Pediatrics: Landrigan, PJ and Etzel, RA, (eds), Oxford University Press, Oxford, UK, 2nd Edition. In Press
• El Kasmi KC, Anderson AL, Devereaux MW, Balasubramaniyan N, Suchy FJ, Orlicky DJ, Shearn CT, Sokol RJ. Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition associated cholestasis in mice. JPEN J Parenter Enteral Nutr. 2021 Oct 19. [Epub ahead of print] PubMed PMID: 34664730
• El Kasmi KC, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D'Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic Activation of Hepatic Farnesoid X Receptor Prevents Parenteral Nutrition Associated Cholestasis in Mice. Hepatology. 2021 Aug 13. [Epub ahead of print] PubMed PMID: 34387888
• Hertel PM, Bull LN, Thompson RJ, Goodrich NP, Ye W, Magee JC, Squires RH, Bass LM, Heubi JE, Kim GE, Ranganathan S, Schwarz KB, Bozic MA, Horslen SP, Clifton MS, Turmelle YP, Suchy FJ, Superina RA, Wang KS, Loomes KM, Kamath BM, Sokol RJ, Shneider BL. Mutation Analysis and Disease Features at Presentation in a Multi-Center Cohort of Children With Monogenic Cholestasis. J Pediatr Gastroenterol Nutr. 2021 Aug 1;73(2):169-177. PubMed PMID: 34016879
• van Wessel DBE, Thompson RJ, Gonzales E, Jankowska I, Shneider BL, Sokal E, Grammatikopoulos T, Kadaristiana A, Jacquemin E, Spraul A, Lipinski P, Czubkowski P, Rock N, Shagrani M, Broering D, Algoufi T, Mazhar N, Nicastro E, Kelly D, Nebbia G, Arnell H, Fischler B, Hulscher JBF, Serranti D, Arikan C, Debray D, Lacaille F, Goncalves C, Hierro L, Muñoz Bartolo G, Mozer-Glassberg Y, Azaz A, Brecelj J, Dezsofi A, Luigi Calvo P, Krebs-Schmitt D, Hartleif S, van der Woerd WL, Wang JS, Li LT, Durmaz Ö, Kerkar N, Hørby Jørgensen M, Fischer R, Jimenez-Rivera C, Alam S, Cananzi M, Laverdure N, Targa Ferreira C, Ordonez F, Wang H, Sency V, Mo Kim K, Chen HL, Carvalho E, Fabre A, Quintero Bernabeu J, Alonso EM, Sokol RJ, Suchy FJ, Loomes KM, McKiernan PJ, Rosenthal P, Turmelle Y, Rao GS, Horslen S, Kamath BM, Rogalidou M, Karnsakul WW, Hansen B, Verkade HJ. Impact of Genotype, Serum Bile Acids, and Surgical Biliary Diversion on Native Liver Survival in FIC1 Deficiency. Hepatology. 2021 Aug;74(2):892-906. PubMed PMID: 33666275
• Balasubramaniyan N, Devereaux MW, Orlicky D, Sokol RJ, and Suchy FJ: miR-199a-5p Regulates the Expression of ABCB11 in Obstructive Cholestasis. J Biological Chem (in Press)
• Suchy FJ, Sokol RJ, Balistreri WB, Mack C, Shneider BL, and Bezerra J (eds): Liver Disease in Children, 5th Edition, Cambridge University Press, Cambridge, UK, 2021
• Suchy FJ: Functional development of the liver. IN: Liver Disease in Children. Suchy FJ, Sokol RJ, Balistreri WB, Mack C, Shneider BL, and Bezerra J (eds): 5th ed., Cambridge University Press, Cambridge , UK, 2021, pp. 12-26.
• Feldman A, Suchy FJ: Approach to the infant with cholestasis. IN: Liver Disease in Children. Suchy FJ, Sokol RJ, Balistreri WB, Mack C, Shneider BL, and Bezerra J (eds): 5th Edition ,Cambridge University Press, Cambridge, UK, 2021, pp. 107-116.
• Feldman A, Suchy FJ: Approach to the infant with cholestasis. IN: Liver Disease in Children. Suchy FJ, Sokol RJ, Balistreri WB, Mack C, Shneider BL, and Bezerra J (eds): 5th Edition ,Cambridge University Press, Cambridge, UK, 2021, pp. 107-116.
• Arnon R, Chu J Suchy FJ: Hepatic fibrocystic disease. IN: Liver Disease in Children. Suchy FJ, Sokol RJ, Balistreri WB, Mack C, Shneider BL, and Bezerra J (eds): 5th ed., Cambridge University Press, Cambridge , UK, 2021 pp. 740-769.
• Suchy FJ, Sokol RJ: Medical Management of cholestasis in infants and children. IN: Liver Disease in Children. Suchy FJ, Sokol RJ, Balistreri WB, Mack C, Shneider BL, and Bezerra J (eds) 5th ed.: Cambridge University Press, Cambridge, UK, 2021, pp. 116-147.
• Suchy FJ: Hepatobiliary function. IN: Concise Medical Physiology. Boron WF and Boulpaep EL. (eds), Elsevier, Philadelphia, PA, 2021, pp. 496-512.
• Balasubramaniyan N, Devereaux MW, Orlicky DJ, Sokol RJ Frederick J Suchy FJ: miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis J Biol Chem. 12;297(6):101400, 2021.
• Shneider BL and Suchy FJ: Autoimmune Hepatitis. IN: Nelson Textbook of Pediatrics, 21th Edition. RM Kliegman, BF Stanton, J St. Geme and N Schor (eds), Elsevier, Philadelphia, PA , 2020, pp. 2127-2129.
• Suchy FJ and Feldman A: Drug and Toxin-related Liver Injury. IN: Nelson Textbook of Pediatrics, 21th Edition. RM Kliegman, BF Stanton, J St. Geme and N Schor (eds), Elsevier, Philadelphia, PA, 2020, pp. 2130-2132.
• Suchy FJ and Feldman A: Fulminant Hepatic Failure, IN: Nelson Textbook of Pediatrics, 21th Edition. RM Kliegman, BF Stanton, J St. Geme and N Schor (eds), Elsevier, Philadelphia, PA, 2020, pp. 2133-2135.
• Suchy FJ and Feldman A: Cystic Diseases of the Biliary Tract and Liver IN: Nelson Textbook of Pediatrics, 21th Edition. RM Kliegman, BF Stanton, J St. Geme and N Schor (eds), Elsevier, Philadelphia, PA , 2020, pp. 2135-2138.
• Pediatrics, 21th Edition. RM Kliegman, BF Stanton, J St. Geme and N Schor (eds), Elsevier, Philadelphia, PA, 2020, pp. 2139-2140.
• Suchy FJ and Feldman A: Portal hypertension and varices. IN: Nelson Textbook of Pediatrics, 21th Edition. RM Kliegman, BF Stanton, J St. Geme and N Schor (eds), Elsevier, Philadelphia, PA, 2020, pp. 2141-2142.
• Suchy FJ: Anatomy, histology, developmental anomalies and pediatric disorders of the biliary tract. IN: Gastrointestinal and Liver Disease, 11th edition. M Feldman, LS Friedman, LJ Brandt (eds), Elsevier, Philadelphia, 2020, pp. 1055-1077.
• Balasubramaniyan N, Devereaux MW, Orlicky DJ, Sokol RJ, Suchy FJ. Up-regulation of miR-let7a-5p Leads to Decreased Expression of ABCC2 in Obstructive Cholestasis. Hepatol Commun. 2019 Dec;3(12):1674-1686. PubMed PMID: 31832574
• Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Bezerra JA, Magee JC. Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial. J Pediatr. 2018 Nov;202:179-185.e4. PubMed PMID: 30244988
• Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PLoS One. 2016 Jun 28;11(6):e0158269. PubMed PMID: 27351185
• Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Nuclear factor-?B regulates the expression of multiple genes encoding liver transport proteins. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G618-28. PubMed PMID: 26867564
• Aguilo F, Li S, Balasubramaniyan N, Sancho A, Benko S, Zhang F, Vashisht A, Rengasamy M, Andino B, Chen CH, Zhou F, Qian C, Zhou MM, Wohlschlegel JA, Zhang W, Suchy FJ, Walsh MJ. Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1a. Cell Rep. 2016 Jan 26;14(3):479-92. PubMed PMID: 26774474
• Suchy FJ, Ananthanarayanan M. Bile acid hepatotoxicity: Epigenetics comes to the rescue. Hepatology. 2015 Jul;62(1):22-4. PubMed PMID: 25808941
• Sancho A, Li S, Paul T, Zhang F, Aguilo F, Vashisht A, Balasubramaniyan N, Leleiko NS, Suchy FJ, Wohlschlegel JA, Zhang W, Walsh MJ. CHD6 regulates the topological arrangement of the CFTR locus. Hum Mol Genet. 2015 May 15;24(10):2724-32. PubMed PMID: 25631877
• Suchy FJ, Ananthanarayanan M. Bile acid hepatotoxicity: Epigenetics comes to the rescue. Hepatology. 2015 Jul;62(1):22-4. PubMed PMID: 25808941
• Sancho A, Li S, Paul T, Zhang F, Aguilo F, Vashisht A, Balasubramaniyan N, Leleiko NS, Suchy FJ, Wohlschlegel JA, Zhang W, Walsh MJ. CHD6 regulates the topological arrangement of the CFTR locus. Hum Mol Genet. 2015 May 15;24(10):2724-32. PubMed PMID: 25631877
• Xu S, Sun AQ, Suchy FJ. A novel RARa/CAR-mediated mechanism for regulation of human organic solute transporter-ß gene expression. Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G154-62. PubMed PMID: 24264050
• Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ, Childhood Liver Disease Research and Education Network (ChiLDREN). Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. JAMA. 2014 May 7;311(17):1750-9. PubMed PMID: 24794368
• Xu S, Sun AQ, Suchy FJ. A novel RARa/CAR-mediated mechanism for regulation of human organic solute transporter-ß gene expression. Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G154-62. PubMed PMID: 24264050
• Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ. Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. JAMA. 2014 May 7;311(17):1750-9. PubMed PMID: 24794368
• Xu S, Sun AQ, Suchy FJ. A novel RARa/CAR-mediated mechanism for regulation of human organic solute transporter-ß gene expression. Am J Physiol Gastrointest Liver Physiol. 2014 Jan;306(2):G154-62. PubMed PMID: 24264050
• Balasubramaniyan N, Luo Y, Sun AQ, Suchy FJ. SUMOylation of the farnesoid X receptor (FXR) regulates the expression of FXR target genes. J Biol Chem. 2013 May 10;288(19):13850-62. PubMed PMID: 23546875
• Suchy FJ. Biliary atresia in sea lampreys. What can it tell us about the disorder in human infants?. Hepatology. 2013 Jun;57(6):2114-6. PubMed PMID: 23526371
• Sun AQ, Luo Y, Backos DS, Xu S, Balasubramaniyan N, Reigan P, Suchy FJ. Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation. Mol Pharmacol. 2013 May;83(5):1078-86. PubMed PMID: 23462506
• Kerkar N, D'Urso C, Van Nostrand K, Kochin I, Gault A, Suchy F, Miloh T, Arnon R, Chu J, Annunziato R. Psychosocial outcomes for children with nonalcoholic fatty liver disease over time and compared with obese controls. J Pediatr Gastroenterol Nutr. 2013 Jan;56(1):77-82. PubMed PMID: 22925921
• Sun AQ, Zhu L, Luo Y, Xu S, Lin J, Suchy FJ. Human Organic Solute Transporter (hOST): protein interaction and membrane sorting process. Int J Biochem Mol Biol. 2012;3(3):290-301. PubMed PMID: 23097745
• Kerkar N, D'Urso C, Van Nostrand K, Kochin I, Gault A, Suchy F, Miloh T, Arnon R, Chu J, Annunziato R. Psychosocial Outcomes for Children with Nonalcoholic Fatty Liver Disease over Time and Compared to Obese Controls. J Pediatr Gastroenterol Nutr. 2012 Aug 24. [Epub ahead of print] PubMed PMID: 22925921
• Shneider BL, Magee JC, Bezerra JA, Haber B, Karpen SJ, Raghunathan T, Rosenthal P, Schwarz K, Suchy FJ, Kerkar N, Turmelle Y, Whitington PF, Robuck PR, Sokol RJ, Childhood Liver Disease Research Education Network (ChiLDREN). Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia. Pediatrics. 2012 Sep;130(3):e607-14. PubMed PMID: 22891232
• Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA, Baldán A. miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity. EMBO Mol Med. 2012 Sep;4(9):882-95. PubMed PMID: 22767443
• Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes. Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G937-47. PubMed PMID: 22345554
• Tomaino J, Keegan T, Miloh T, Kerkar N, Mercer S, Birge M, Rocca J, Suchy F, Arnon R. Stevens-Johnson syndrome after Mycoplasma pneumonia infection in pediatric post-liver transplant recipient: case report and review of the literature. Pediatr Transplant. 2012 May;16(3):E74-7. PubMed PMID: 21176015
• Feldman AG, Suchy FJ: Metabolic and Genetic Disorders of the Liver. In: Rudolph’s Pediatrics. Kline M (ed), 23rd ed. McGraw Hill, New York, NY. (In Press)
• Feldman A and Suchy FJ: Autoimmune Hepatitis. IN: Nelson Textbook of Pediatrics, 22th Edition RM Kliegman, St Geme J, Blum NJ, Shah SS, Tasker RC and Wilson KM (eds), Elsevier, Philadelphia, PA, In Press
• Suchy FJ and Feldman A: Drug and Toxin-related Liver Injury. IN: Nelson Textbook of Pediatrics, 22th Edition. RM Kliegman, St Geme J, Blum NJ, Shah SS, Tasker RC and Wilson KM (eds), Elsevier, Philadelphia, PA, In Press
• Feldman A and SuchyFJ: Fulminant Hepatic Failure, IN: Nelson Textbook of Pediatrics, 22th Edition. RM Kliegman, St Geme J, Blum NJ, Shah SS, Tasker RC and Wilson KM (eds), Elsevier, Philadelphia, PA, In Press
• Suchy FJ and Feldman A: Diseases of the Gall Bladder IN: Nelson Textbook of Pediatrics, 22th Edition. RM Kliegman, St Geme J, Blum NJ, Shah SS, Tasker RC and Wilson KM (eds), Elsevier, Philadelphia, PA, In Press
• Suchy FJ and Feldman A: Portal hypertension and varices. IN: Nelson Textbook of Pediatrics, 22th Edition. RM Kliegman, St Geme J, Blum NJ, Shah SS, Tasker RC and Wilson KM (eds), Elsevier, Philadelphia, PA, In Press

Professional Memberships

• Association of American Physicians, Member
• American Academy of Pediatrics (AAP), Member
• American Pediatric Society (APS), Member
• International Liver Transplantation Society, Member
• Eastern Society for Pediatric Research (ESPR), Member
• American Gastroenterological Association, Member