Dunbar Ivy, MD

Takatsuki S, Darst JR, Das BB, Fagan TE, Wolfe R, Ivy DD. Clinical manifestations and long-term follow-up in pediatric patients living at altitude with isolated pulmonary artery of ductal origin. Pediatr Cardiol. 2012 Jun;33(5):775-81. PubMed PMID: 22430374

Takatsuki S, Calderbank M, Ivy DD. Initial experience with tadalafil in pediatric pulmonary arterial hypertension. Pediatr Cardiol. 2012 Jun;33(5):683-8. PubMed PMID: 22402804

Stoica S, Carpenter E, Campbell D, Mitchell M, da Cruz E, Ivy D, Lacour-Gayet F. Morbidity of the arterial switch operation. Ann Thorac Surg. 2012 Jun;93(6):1977-83. PubMed PMID: 22365263

Takatsuki S, Wagner BD, Ivy DD. B-type natriuretic peptide and amino-terminal pro-B-type natriuretic peptide in pediatric patients with pulmonary arterial hypertension. Congenit Heart Dis. 2012 May-Jun;7(3):259-67. PubMed PMID: 22325151

Ivy D. Advances in pediatric pulmonary arterial hypertension. Curr Opin Cardiol. 2012 Mar;27(2):70-81. PubMed PMID: 22274573

Berger RM, Beghetti M, Humpl T, Raskob GE, Ivy DD, Jing ZC, Bonnet D, Schulze-Neick I, Barst RJ. Clinical features of paediatric pulmonary hypertension: a registry study. Lancet. 2012 Feb 11;379(9815):537-46. PubMed PMID: 22240409

Feinstein JA, Benson DW, Dubin AM, Cohen MS, Maxey DM, Mahle WT, Pahl E, Villafañe J, Bhatt AB, Peng LF, Johnson BA, Marsden AL, Daniels CJ, Rudd NA, Caldarone CA, Mussatto KA, Morales DL, Ivy DD, Gaynor JW, Tweddell JS, Deal BJ, Furck AK, Rosenthal GL, Ohye RG, Ghanayem NS, Cheatham JP, Tworetzky W, Martin GR. Hypoplastic left heart syndrome: current considerations and expectations. J Am Coll Cardiol. 2012 Jan 3;59(1 Suppl):S1-42. PubMed PMID: 22192720

Barst RJ, Ivy DD, Gaitan G, Szatmari A, Rudzinski A, Garcia AE, Sastry BK, Pulido T, Layton GR, Serdarevic-Pehar M, Wessel DL. A randomized, double-blind, placebo-controlled, dose-ranging study of oral sildenafil citrate in treatment-naive children with pulmonary arterial hypertension. Circulation. 2012 Jan 17;125(2):324-34. PubMed PMID: 22128226

Barst RJ, McGoon MD, Elliott CG, Foreman AJ, Miller DP, Ivy DD. Survival in childhood pulmonary arterial hypertension: insights from the registry to evaluate early and long-term pulmonary arterial hypertension disease management. Circulation. 2012 Jan 3;125(1):113-22. PubMed PMID: 22086881

Takatsuki S, Ivy DD, Nuss R. Correlation of N-terminal fragment of B-type natriuretic peptide levels with clinical, laboratory, and echocardiographic abnormalities in children with sickle cell disease. J Pediatr. 2012 Mar;160(3):428-433.e1. PubMed PMID: 22048047

Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD, Stenmark KR. Circulating myeloid-derived suppressor cells are increased and activated in pulmonary hypertension. Chest. 2012 Apr;141(4):944-52. PubMed PMID: 21940769

Yeager ME, Belchenko DD, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR. Endothelin-1, the unfolded protein response, and persistent inflammation: role of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 2012 Jan;46(1):14-22. PubMed PMID: 21778413

Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD, Stenmark KR. Circulating fibrocytes are increased in children and young adults with pulmonary hypertension. Eur Respir J. 2012 Jan;39(1):104-11. PubMed PMID: 21700605

Duncan M, Wagner B, Murray K, Allen J, Colvin K, Accurso F, Ivy DD. Circulating cytokines and growth factors in pediatric pulmonary hypertension. Mediators of Inflammation doi:10.1155/2012/143428

Taylor AL, Ivy DD, and Rausch C. VE/VCO2 Slope And Functional Class In Pediatric Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 185: A1903, 2012

De A, Coleman B, Ivy DD, Yaron M, Ward SD. A Rare And Interesting Case Of Syncope At Altitude. Am J Respir Crit Care Med 185: A3384, 2012

Barst RJ, Ivy DD, Rosenzweig EB, Foreman AJ, Turner M, Meltzer LA, and McGoon MD. Characteristics And Four-Year Outcomes Of Patients With Eisenmenger Syndrome In REVEAL. Am J Respir Crit Care Med 185: A4793, 2012

Burgett SL, Kirby KS, Calderbank M, Ivy DD, and Hunter KS. Diameter Of The Pulmonary Artery Measured With Color M-Mode Tissue Doppler Imaging Predicts Clinical Outcomes Better Than Indexed Pulmonary Vascular Resistance In Pediatric Patients With Pulmonary Arterial Hypertension Am. J. Respir. Crit. Care Med. 185: A6739, 2012

Barst RJ, Layton GR, Konourina I, Richardson H, Beghetti, Ivy DD. STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naïve pediatric pulmonary arterial hypertension. Eur Heart Journal 33(Suppl 1): P5340, 2012

Loloyan S, Barst RJ, Brown L, Ivy DD, Rosenzweig EB, Lai G, Elliott CG, Szmuszkovic J, Oudiz R. Time to Recognition of Pediatric Pulmonary Arterial Hypertension: Factors Identified From the REVEAL Registry. Chest 142(4):824A, 2012

Ivy DD. Pulmonary Hypertension. In: McMillan, Barrett, Boney, and Jones eds. Clinical Decision Support: Pediatrics, 2012

Ivy DD. Diagnosis and Treatment of Pediatric Pulmonary Hypertension. In: Allen, Shaddy, Driscoll, Eds. Moss and Adams: Congenital Heart Disease. Philadelphia, Wolters Kluwer Health Lippincott Williams & Wilkins. 1433-1462, 2012

Takatsuki S, Beghetti M, Ivy DD. Pulmonary hypertension in Children. In: Hoeper, Humbert, Eds. European Respiratory Monograph. 57:94–107, 2012

Ivy DD, Abman SH, Barst RJ, Berger RM, Bonnet D, Fleming TR, Haworth SG, Raj JU, Rosenzweig EB, Schulze Neick I, Steinhorn RH, Beghetti M. Pediatric pulmonary hypertension. J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D117-26. PubMed PMID: 24355636

Wagner BD, Takatsuki S, Accurso FJ, Ivy DD. Evaluation of circulating proteins and hemodynamics towards predicting mortality in children with pulmonary arterial hypertension. PLoS One. 2013 Nov 20;8(11):e80235. PubMed PMID: 24278261

Rausch CM, Taylor AL, Ross H, Sillau S, Ivy DD. Ventilatory efficiency slope correlates with functional capacity, outcomes, and disease severity in pediatric patients with pulmonary hypertension. Int J Cardiol. 2013 Nov 30;169(6):445-8. PubMed PMID: 24144928

Colvin KL, Cripe PJ, Ivy DD, Stenmark KR, Yeager ME. Bronchus-associated lymphoid tissue in pulmonary hypertension produces pathologic autoantibodies. Am J Respir Crit Care Med. 2013 Nov 1;188(9):1126-36. PubMed PMID: 24093638

Takatsuki S, Ivy DD. Current challenges in pediatric pulmonary hypertension. Semin Respir Crit Care Med. 2013 Oct;34(5):627-44. PubMed PMID: 24037630

Truong U, Fonseca B, Dunning J, Burgett S, Lanning C, Ivy DD, Shandas R, Hunter K, Barker AJ. Wall shear stress measured by phase contrast cardiovascular magnetic resonance in children and adolescents with pulmonary arterial hypertension. J Cardiovasc Magn Reson. 2013 Sep 13;15:81. PubMed PMID: 24034144

Friesen RH, Nichols CS, Twite MD, Cardwell KA, Pan Z, Pietra B, Miyamoto SD, Auerbach SR, Darst JR, Ivy DD. The hemodynamic response to dexmedetomidine loading dose in children with and without pulmonary hypertension. Anesth Analg. 2013 Oct;117(4):953-9. PubMed PMID: 23960035

Adatia I, Haworth SG, Wegner M, Barst RJ, Ivy D, Stenmark KR, Karkowsky A, Rosenzweig E, Aguilar C. Clinical trials in neonates and children: Report of the pulmonary hypertension academic research consortium pediatric advisory committee. Pulm Circ. 2013 Jan;3(1):252-66. PubMed PMID: 23662203

Grieve AP, Chow SC, Curram J, Dawe S, Harnisch LO, Henig NR, Hung HM, Ivy DD, Kawut SM, Rahbar MH, Xiao S, Wilkins MR. Advancing clinical trial design in pulmonary hypertension. Pulm Circ. 2013 Jan;3(1):217-25. PubMed PMID: 23662200

Maxey DM, Ivy DD, Ogawa MT, Feinstein JA. Food and Drug Administration (FDA) postmarket reported side effects and adverse events associated with pulmonary hypertension therapy in pediatric patients. Pediatr Cardiol. 2013 Oct;34(7):1628-36. PubMed PMID: 23532466

Siehr SL, Ivy DD, Miller-Reed K, Ogawa M, Rosenthal DN, Feinstein JA. Children with pulmonary arterial hypertension and prostanoid therapy: long-term hemodynamics. J Heart Lung Transplant. 2013 May;32(5):546-52. PubMed PMID: 23453572

Zhou Z, Malhotra SP, Yu X, Rutledge J, Rebeyka IM, Ross DB, Rausch C, Gu H, McCrindle B, Lacour-Gayet F, Ivy D, Li J. Moderate altitude is not associated with adverse postoperative outcomes for patients undergoing bidirectional cavopulmonary anastomosis and Fontan operation: a comparative study among Denver, Edmonton, and Toronto. J Thorac Cardiovasc Surg. 2013 Nov;146(5):1165-71. PubMed PMID: 23353110

Takatsuki S, Parker DK, Doran AK, Friesen RH, Ivy DD. Acute pulmonary vasodilator testing with inhaled treprostinil in children with pulmonary arterial hypertension. Pediatr Cardiol. 2013 Apr;34(4):1006-12. PubMed PMID: 23184020

Takatsuki S, Rosenzweig EB, Zuckerman W, Brady D, Calderbank M, Ivy DD. Clinical safety, pharmacokinetics, and efficacy of ambrisentan therapy in children with pulmonary arterial hypertension. Pediatr Pulmonol. 2013 Jan;48(1):27-34. PubMed PMID: 22511577

Beghetti M, Berger RM, Schulze-Neick I, Day RW, Pulido T, Feinstein J, Barst RJ, Humpl T, TOPP Registry Investigators. Diagnostic evaluation of paediatric pulmonary hypertension in current clinical practice. Eur Respir J. 2013 Sep;42(3):689-700. PubMed PMID: 23563261

Wessel DL, Berger F, Li JS, Dähnert I, Rakhit A, Fontecave S, Newburger JW, CLARINET Investigators. Clopidogrel in infants with systemic-to-pulmonary-artery shunts. N Engl J Med. 2013 Jun 20;368(25):2377-84. PubMed PMID: 23782178

Jone PN, Bremen C, DiMaria M, Campbell DN, Jaggers J, Younoszai A, Ivy DD. Three-Dimensional Echocardiography Enhances Diagnostic Accuracy of Supramitral Ring. Echocardiography. 2014 Dec 12. PubMed PMID: 25496227

Jone PN, Ivy DD. Echocardiography in pediatric pulmonary hypertension. Front Pediatr. 2014;2:124. PubMed PMID: 25429362

Nies MK, Ivy DD, Everett AD. The untapped potential of proteomic analysis in pediatric pulmonary hypertension. Proteomics Clin Appl. 2014 Dec;8(11-12):862-74. PubMed PMID: 25348110

Nicolarsen J, Ivy D. Progress in the diagnosis and management of pulmonary hypertension in children. Curr Opin Pediatr. 2014 Oct;26(5):527-35. PubMed PMID: 25136947

Lopes AA, Barst RJ, Haworth SG, Rabinovitch M, Al Dabbagh M, Del Cerro MJ, Ivy D, Kashour T, Kumar K, Harikrishnan S, D'Alto M, Thomaz AM, Zorzanelli L, Aiello VD, Mocumbi AO, Santana MV, Galal AN, Banjar H, Tamimi O, Heath A, Flores PC, Diaz G, Sandoval J, Kothari S, Moledina S, Gonçalves RC, Barreto AC, Binotto MA, Maia M, Al Habshan F, Adatia I. Repair of congenital heart disease with associated pulmonary hypertension in children: what are the minimal investigative procedures? Consensus statement from the Congenital Heart Disease and Pediatric Task Forces, Pulmonary Vascular Research Institute (PVRI). Pulm Circ. 2014 Jun;4(2):330-41. PubMed PMID: 25006452

Di Maria MV, Younoszai AK, Mertens L, Landeck BF 2nd, Ivy DD, Hunter KS, Friedberg MK. RV stroke work in children with pulmonary arterial hypertension: estimation based on invasive haemodynamic assessment and correlation with outcomes. Heart. 2014 Sep;100(17):1342-7. PubMed PMID: 24780910

Zijlstra WM, Douwes JM, Rosenzweig EB, Schokker S, Krishnan U, Roofthooft MT, Miller-Reed K, Hillege HL, Ivy DD, Berger RM. Survival differences in pediatric pulmonary arterial hypertension: clues to a better understanding of outcome and optimal treatment strategies. J Am Coll Cardiol. 2014 May 27;63(20):2159-69. PubMed PMID: 24681143

Barst RJ, Beghetti M, Pulido T, Layton G, Konourina I, Zhang M, Ivy DD, STARTS-2 Investigators. STARTS-2: long-term survival with oral sildenafil monotherapy in treatment-naive pediatric pulmonary arterial hypertension. Circulation. 2014 May 13;129(19):1914-23. PubMed PMID: 24637559

Colvin KL, Dufva MJ, Delaney RP, Ivy DD, Stenmark KR, Yeager ME. Biomarkers for pediatric pulmonary arterial hypertension - a call to collaborate. Front Pediatr. 2014;2:7. PubMed PMID: 24551834

Jone PN, Hinzman J, Wagner BD, Ivy DD, Younoszai A. Right ventricular to left ventricular diameter ratio at end-systole in evaluating outcomes in children with pulmonary hypertension. J Am Soc Echocardiogr. 2014 Feb;27(2):172-8. PubMed PMID: 24325962

Barst RJ, Ivy DD, Foreman AJ, McGoon MD, Rosenzweig EB. Four- and seven-year outcomes of patients with congenital heart disease-associated pulmonary arterial hypertension (from the REVEAL Registry). Am J Cardiol. 2014 Jan 1;113(1):147-55. PubMed PMID: 24176071

Vorhies EE, Ivy DD. Drug treatment of pulmonary hypertension in children. Paediatr Drugs. 2014 Feb;16(1):43-65. PubMed PMID: 24114695

Douwes JM, Barst RJ, Humpl T, Beghettit M, Bonnet D, Schulze-Neick I, Ivy DD, Berger RMF. Acute vasodilator response in paediatric pulmonary arterial hypertension: current clinical practice from the TOPP-registry. Cardiology in the Young 24(Suppl. 1), S18, 2014

Takatsuki S, Naoi K, Ikehara S, Nakayama T, Matsuura H, Ivy DD, Saji T. Serial assessment of pulmonary arterial capacitance index during midterm follow-up predicts adverse outcomes in children with idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 189;A3252,2014

Yeager ME, Colvin KL, Ivy DD, Bull TM, Stenmark KR. Reduced phagocytic capacity drives experimental pulmonary hypertension. Am J Respir Crit Care Med 189;A3355,2014

Yeager ME, Colvin KL, Ivy DD, Stenmark KR. Cardiopulmonary lymphatic vessel dynamics and development of right ventricular edema in experimental pulmonary hypertension. Am J Respir Crit Care Med 189;A5551,2014

Di Maria M, Fagan T, Wilson N, Mitchell M, Campbell D, Jaggers J, da Cruz EM, Ivy DD, Younoszai A. Pre-Superior cavopulmonary anastomosis cardiac catheterization at altitude. Circulation 130:A19807, 2014

Agyei-Ntim F, Hunter K, Truong U, Ivy DD, Shandas R. Statistical Shape Modeling of the Right Ventricle Differentiates Stages of RV Remodeling in Children With Pulmonary Hypertension: An Initial Analysis Circulation 130:A15746, 2014

Colvin KL, Lohani O, Williams SM, Ivy DD, Stenmark K, Yeager M. Right Ventricle Lymphatic Vessel Insufficiency Contributes to Interstitial Fluid Stasis, Inflammation, Fibrosis, and Failure in Pulmonary Hypertension Circulation 130:A11636, 2014

Takatsuki S, Eshelman J, Berg, A, Ivy DD. Pharmacological treatment of Pulmonary Hypertension. RMunoz, et al. (eds.), Handbook of Pediatric Cardiovascular Drugs, Springer-Verlag London 2014

Burkett DA, Slorach C, Patel SS, Redington AN, Ivy DD, Mertens L, Younoszai AK, Friedberg MK. Left Ventricular Myocardial Function in Children With Pulmonary Hypertension: Relation to Right Ventricular Performance and Hemodynamics. Circ Cardiovasc Imaging. 2015 Aug;8(8). PubMed PMID: 26259580

Abman SH, Ivy DD. Hospitalizations of Children With Pulmonary Hypertension: Implications for Improving Care. Pediatrics. 2015 Aug;136(2):392-3. PubMed PMID: 26148953

Rosenkranz S, Ghofrani HA, Beghetti M, Ivy D, Frey R, Fritsch A, Weimann G, Saleh S, Apitz C. Riociguat for pulmonary arterial hypertension associated with congenital heart disease. Heart. 2015 Nov 15;101(22):1792-9. PubMed PMID: 26135803

Webber SA, Hsu DT, Ivy DD, Kulik TJ, Pahl E, Rosenthal DN, Morrow WR, Feinstein JA. Task Force 7: Pediatric Cardiology Fellowship Training in Pulmonary Hypertension, Advanced Heart Failure, and Transplantation. J Am Coll Cardiol. 2015 Aug 11;66(6):732-9. PubMed PMID: 25777654

Ross RD, Brook M, Feinstein JA, Koenig P, Lang P, Spicer R, Vincent JA, Lewis AB, Martin GR, Bartz PJ, Fischbach PS, Fulton DR, Matherne GP, Reinking B, Srivastava S, Printz B, Geva T, Shirali GS, Weinberg P, Wong PC, Armsby LB, Vincent RN, Foerster SR, Holzer RJ, Moore JW, Marshall AC, Latson L, Dubin AM, Walsh EP, Franklin W, Kanter RJ, Saul JP, Shah MJ, Van Hare GF, Feltes TF, Roth SJ, Almodovar MC, Andropoulos DB, Bohn DJ, Costello JM, Gajarski RJ, Mott AR, Stout K, Valente AM, Cook S, Gurvitz M, Saidi A, Webber SA, Hsu DT, Ivy DD, Kulik TJ, Pahl E, Rosenthal DN, Morrow R, Mahle WT, Murphy AM, Li JS, Law YM, Newburger JW, Daniels SR, Bernstein D, Marino BS. 2015 SPCTPD/ACC/AAP/AHA Training Guidelines for Pediatric Cardiology Fellowship Programs (Revision of the 2005 Training Guidelines for Pediatric Cardiology Fellowship Programs). J Am Coll Cardiol. 2015 Mar 13. [Epub ahead of print] PubMed PMID: 25777637

Webber SA, Hsu DT, Ivy DD, Kulik TJ, Pahl E, Rosenthal DN, Morrow WR, Feinstein JA. Task Force 7: Pediatric Cardiology Fellowship Training in Pulmonary Hypertension, Advanced Heart Failure, and Transplantation. SPCTPD/ACC/AAP/AHA. Circulation. 2015 Aug 11;132(6):e99-e106. PubMed PMID: 25769631

Ivy DD, Abman SH. Gaining insights into pediatric pulmonary hypertensive disorders through patient registries. Am J Respir Crit Care Med. 2015 Jan 1;191(1):2-4. PubMed PMID: 25551339

Jone PN, Bremen C, DiMaria M, Campbell DN, Jaggers J, Younoszai A, Ivy DD. Three-dimensional echocardiography enhances diagnostic accuracy of supramitral ring. Echocardiography. 2015 Jun;32(6):1048-50. PubMed PMID: 25496227

Kheyfets VO, Dunning J, Truong U, Ivy DD, Hunter KA, Shandas R. Assessment of N-terminal prohormone B-type natriuretic peptide as a measure of vascular and ventricular function in pediatric pulmonary arterial hypertension. Pulm Circ. 2015 Dec;5(4):658-66. PubMed PMID: 26697173

Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015 Nov 24;132(21):2037-99. PubMed PMID: 26534956

Truong U, Patel S, Kheyfets V, Dunning J, Fonseca B, Barker AJ, Ivy D, Shandas R, Hunter K. Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension. J Cardiovasc Magn Reson. 2015 Sep 16;17(1):81. PubMed PMID: 26376972

Ivy DD, Abman S. Beyond the 6-Minute Walk Test for Assessing Pediatric Pulmonary Hypertension: Making Strides Through Combination End Points. Chest. 2015 Sep;148(3):576-7. PubMed PMID: 26324131

Di Maria MV, Burkett DA, Younoszai AK, Landeck BF 2nd, Mertens L, Ivy DD, Friedberg MK, Hunter KS. Echocardiographic Estimation of Right Ventricular Stroke Work in Children with Pulmonary Arterial Hypertension: Comparison with Invasive Measurements. J Am Soc Echocardiogr. 2015 Nov;28(11):1350-7. PubMed PMID: 26299333

Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman JR, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH. Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension. J Pediatr. 2015 Dec 15. [Epub ahead of print] PubMed PMID: 26703869

Patel SS, Fernie JC, Taylor AL, Ivy DD, Rausch CM. Evaluation of predictive models for six minute walk test among children with pulmonary hypertension. Int J Cardiol. 2016 Nov 7. [Epub ahead of print] PubMed PMID: 27838122

Clopton RG, Friesen R, Partrick D, Wilson N, Jaggers J, Ivy DD, Schwartz LI, Ing RJ. The Anesthetic Challenges of Lung Biopsy-Associated Intrathoracic Hemorrhage in a Child With Suprasystemic Pulmonary Hypertension. Semin Cardiothorac Vasc Anesth. 2016 Nov 3. [Epub ahead of print] PubMed PMID: 27815350

Takatsuki S, Nakayama T, Ikehara S, Matsuura H, Ivy DD, Saji T. Pulmonary Arterial Capacitance Index Is a Strong Predictor for Adverse Outcome in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. J Pediatr. 2016 Oct 31. [Epub ahead of print] PubMed PMID: 27810156

Hauck A, Guo R, Ivy DD, Younoszai A. Tricuspid annular plane systolic excursion is preserved in young patients with pulmonary hypertension except when associated with repaired congenital heart disease. Eur Heart J Cardiovasc Imaging. 2016 Apr 20. [Epub ahead of print] PubMed PMID: 27099276

Colvin KL, Ivy DD, Yeager ME. Altered Peripheral Blood Myeloid Cell Subpopulations in Children With Down Syndrome and Pulmonary Hypertension. J Pediatr Hematol Oncol. 2017 Jan 5. [Epub ahead of print] PubMed PMID: 28060127

Humpl T, Berger RM, Austin ED, Fasnacht Boillat MS, Bonnet D, Ivy DD, Zuk M, Beghetti M, Schulze-Neick I. Treatment initiation in paediatric pulmonary hypertension: insights from a multinational registry. Cardiol Young. 2016 Dec 20;:1-10. [Epub ahead of print] PubMed PMID: 27995825

Abman SH, Ivy DD, Archer SL, Wilson K. Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Oct 1;194(7):898-906. PubMed PMID: 27689707

Kheyfets VO, Dunning J, Truong U, Ivy D, Hunter K, Shandas R. A 0-D Model and Protocol for Simulating Patient Specific Pulmonary Hemodynamics from Limited Clinical Data. J Biomech Eng. 2016 Sep 29. [Epub ahead of print] PubMed PMID: 27684888

Zijlstra WM, Douwes JM, Ploegstra MJ, Krishnan U, Roofthooft MT, Hillege HL, Ivy DD, Rosenzweig EB, Berger RM. Clinical classification in pediatric pulmonary arterial hypertension associated with congenital heart disease. Pulm Circ. 2016 Sep;6(3):302-12. PubMed PMID: 27683607

Berger RM, Haworth SG, Bonnet D, Dulac Y, Fraisse A, Galiè N, Ivy DD, Jaïs X, Miera O, Rosenzweig EB, Efficace M, Kusic-Pajic A, Beghetti M. Corrigendum to "FUTURE-2: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion" [Int. J. Cardiol. 202 (2016) 52-58]. Int J Cardiol. 2016 Aug 24. [Epub ahead of print] PubMed PMID: 27623401

Burkett DA, Slorach C, Patel SS, Redington AN, Ivy DD, Mertens L, Younoszai AK, Friedberg MK. Impact of Pulmonary Hemodynamics and Ventricular Interdependence on Left Ventricular Diastolic Function in Children With Pulmonary Hypertension. Circ Cardiovasc Imaging. 2016 Sep;9(9). PubMed PMID: 27581953

Schäfer M, Truong U, Browne LP, Morgan GJ, Ross M, Ing R, Hunter KS, Kheyfets VO, Abman SH, Ivy DD, Wilson N. Measuring Flow Hemodynamic Indices and Oxygen Consumption in Children with Pulmonary Hypertension: A Comparison of Catheterization and Phase-Contrast MRI. Pediatr Cardiol. 2017 Oct 17. [Epub ahead of print] PubMed PMID: 29043395

Schäfer M, Ivy DD, Barker AJ, Kheyfets V, Shandas R, Abman SH, Hunter KS, Truong U. Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2016 Jul 21. [Epub ahead of print] PubMed PMID: 27444679

Friesen RM, Schäfer M, Burkett DA, Cassidy CJ, Ivy DD, Jone PN. Right Ventricular Tissue Doppler Myocardial Performance Index in Children with Pulmonary Hypertension: Relation to Invasive Hemodynamics. Pediatr Cardiol. 2017 Oct 4. [Epub ahead of print] PubMed PMID: 28980052

Jone PN, Schäfer M, Pan Z, Bremen C, Ivy DD. 3D echocardiographic evaluation of right ventricular function and strain: a prognostic study in paediatric pulmonary hypertension. Eur Heart J Cardiovasc Imaging. 2017 Aug 25. [Epub ahead of print] PubMed PMID: 28950335

Kheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas R. Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function. Oxid Med Cell Longev. 2017;2017:4957147. PubMed PMID: 28819545

Sable CA, Ivy DD, Beekman RH 3rd, Clayton-Jeter HD, Jenkins KJ, Mahle WT, Morrow WR, Murphy MD, Nelson RM, Rosenthal GL, Stockbridge N, Wessel DL. 2017 ACC/AAP/AHA Health Policy Statement on Opportunities and Challenges in Pediatric Drug Development: Learning From Sildenafil. J Am Coll Cardiol. 2017 Jul 25;70(4):495-503. PubMed PMID: 28669447

Sable CA, Ivy DD, Beekman RH 3rd, Clayton-Jeter HD, Jenkins KJ, Mahle WT, Morrow WR, Murphy MD, Nelson RM, Rosenthal GL, Stockbridge N, Wessel DL. 2017 ACC/AAP/AHA Health Policy Statement on Opportunities and Challenges in Pediatric Drug Development: Learning From Sildenafil. Circ Cardiovasc Qual Outcomes. 2017 Jul;10(7). PubMed PMID: 28663437

Krishnan U, Feinstein JA, Adatia I, Austin ED, Mullen MP, Hopper RK, Hanna B, Romer L, Keller RL, Fineman J, Steinhorn R, Kinsella JP, Ivy DD, Rosenzweig EB, Raj U, Humpl T, Abman SH. Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia. J Pediatr. 2017 Sep;188:24-34.e1. PubMed PMID: 28645441

Parker DK, Shen S, Zheng J, Ivy DD, Crotwell DN, Hotz JC, DiBlasi RM. Inhaled Treprostinil Drug Delivery During Mechanical Ventilation and Spontaneous Breathing Using Two Different Nebulizers. Pediatr Crit Care Med. 2017 Jun;18(6):e253-e260. PubMed PMID: 28441181

Ivy D. Pulmonary Hypertension in Children. Cardiol Clin. 2016 Aug;34(3):451-72. PubMed PMID: 27443141

Yang J, Nies MK, Fu Z, Damico R, Korley FK, Hassoun PM, Ivy DD, Austin ED, Everett AD. Hepatoma Derived Growth Factor Predicts Disease Severity and Survival in Pulmonary Artery Hypertension. Am J Respir Crit Care Med. 2016 Jun 2. [Epub ahead of print] PubMed PMID: 27254543

Del Cerro MJ, Moledina S, Haworth SG, Ivy D, Al Dabbagh M, Banjar H, Diaz G, Heath-Freudenthal A, Galal AN, Humpl T, Kulkarni S, Lopes A, Mocumbi AO, Puri GD, Rossouw B, Harikrishnan S, Saxena A, Udo P, Caicedo L, Tamimi O, Adatia I. Cardiac catheterization in children with pulmonary hypertensive vascular disease: consensus statement from the Pulmonary Vascular Research Institute, Pediatric and Congenital Heart Disease Task Forces. Pulm Circ. 2016 Mar;6(1):118-25. PubMed PMID: 27076908

Ploegstra MJ, Ivy DD, Wheeler JG, Brand M, Beghetti M, Rosenzweig EB, Humpl T, Iriart X, Rouzic EM, Bonnet D, Berger RM. Growth in children with pulmonary arterial hypertension: a longitudinal retrospective multiregistry study. Lancet Respir Med. 2016 Apr;4(4):281-90. PubMed PMID: 26994897

Douwes JM, Humpl T, Bonnet D, Beghetti M, Ivy DD, Berger RM. Acute Vasodilator Response in Pediatric Pulmonary Arterial Hypertension: Current Clinical Practice From the TOPP Registry. J Am Coll Cardiol. 2016 Mar 22;67(11):1312-23. PubMed PMID: 26988953

Berger RMF, Gehin M, Beghetti M, Ivy D, Kusic-Pajic A, Cornelisse P, Grill S, Bonnet D. A bosentan pharmacokinetic study to investigate dosing regimens in paediatric patients with pulmonary arterial hypertension: FUTURE-3. Br J Clin Pharmacol. 2017 Aug;83(8):1734-1744. PubMed PMID: 28213957

Schäfer M, Ivy DD, Abman SH, Barker AJ, Browne LP, Fonseca B, Kheyfets V, Hunter KS, Truong U. Apparent Aortic Stiffness in Children With Pulmonary Arterial Hypertension: Existence of Vascular Interdependency?. Circ Cardiovasc Imaging. 2017 Feb;10(2). PubMed PMID: 28193613

Zijlstra WM, Elmasry O, Pepplinkhuizen S, Ivy DD, Bonnet D, Luijendijk P, Lévy M, Gavilan JL, Torrent-Vernetta A, Mendoza A, Del Cerro MJ, Moledina S, Berger RM. Pulmonary arterial hypertension in children after neonatal arterial switch operation. Heart. 2017 Aug;103(16):1244-1249. PubMed PMID: 28115472

Colvin KL, Ivy DD, Yeager ME. Altered Peripheral Blood Myeloid Cell Subpopulations in Children With Down Syndrome and Pulmonary Hypertension. J Pediatr Hematol Oncol. 2017 Mar;39(2):158-159. PubMed PMID: 28060127

Humpl T, Berger RMF, Austin ED, Fasnacht Boillat MS, Bonnet D, Ivy DD, Zuk M, Beghetti M, Schulze-Neick I. Treatment initiation in paediatric pulmonary hypertension: insights from a multinational registry. Cardiol Young. 2017 Aug;27(6):1123-1132. PubMed PMID: 27995825

Patel SS, Fernie JC, Taylor AL, Ivy DD, Rausch CM. Evaluation of predictive models for six minute walk test among children with pulmonary hypertension. Int J Cardiol. 2017 Jan 15;227:393-398. PubMed PMID: 27838122

Clopton RG, Friesen R, Partrick D, Wilson N, Jaggers J, Ivy DD, Schwartz LI, Ing RJ. The Anesthetic Challenges of Lung Biopsy-Associated Intrathoracic Hemorrhage in a Child With Suprasystemic Pulmonary Hypertension. Semin Cardiothorac Vasc Anesth. 2017 Jun;21(2):172-177. PubMed PMID: 27815350

Takatsuki S, Nakayama T, Ikehara S, Matsuura H, Ivy DD, Saji T. Pulmonary Arterial Capacitance Index Is a Strong Predictor for Adverse Outcome in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension. J Pediatr. 2017 Jan;180:75-79.e2. PubMed PMID: 27810156

Hauck A, Guo R, Ivy DD, Younoszai A. Tricuspid annular plane systolic excursion is preserved in young patients with pulmonary hypertension except when associated with repaired congenital heart disease. Eur Heart J Cardiovasc Imaging. 2017 Apr 1;18(4):459-466. PubMed PMID: 27099276

Schäfer M, Ivy DD, Barker AJ, Kheyfets V, Shandas R, Abman SH, Hunter KS, Truong U. Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2017 Apr 1;18(4):424-431. PubMed PMID: 27444679

Kim JS, McSweeney J, Lee J, Ivy D. Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: Pharmacotherapies in Cardiac Critical Care Pulmonary Hypertension. Pediatr Crit Care Med. 2016 Mar;17(3 Suppl 1):S89-100. PubMed PMID: 26945333

Jone PN, Schäfer M, Li L, Craft M, Ivy DD, Kutty S. Right Atrial Deformation in Predicting Outcomes in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2017 Feb;10(2). PubMed PMID: 28950335

Nies MN, Yang J, Damico RL, Vaidya D, Ivy DD, Austin E, Hirsch R, Yung D, Rosenzweig E, Puuciulo M, Nichols W, Everett A. Hepatoma-Derived growth factor predicts disease severity in pediatric pulmonary arterial hypertension. Am J Respir Crit Care Med 195:A2652 , 2017

Jone PN, Bremen C, Mulvahill M, Ivy DD. Relation of Three-Dimensional Echocardiography Evaluation of Right Ventricular Volumes to Right Ventricular Strain in Pediatric Pulmonary Hypertension. Am J Respir Crit Care Med 195:A6180, 2017

Giesenhagen A, Brinton J, Ivy DD, Meier MR, Weinman JP, Liptzin D. What the HAPE is going on: High altitude pulmonary edema at Children’s Hospital Colorado. Am J Respir Crit Care Med 195:A6877, 2017

Jone PN, Schäfer M, Bremen C, Ivy DD. Relation of Right Ventricular Volumes and Strain using Three-Dimensional Echocardiography in Pediatric Pulmonary Hypertension. 11th Pulmonary Vascular Research Institute Annual World Congress on PVD in Miami, FL, January, 2017.

Friesen RM, Schäfer M, Burkett DA, Ivy DD, Cassidy C, Jone PN. Right Ventricular Tissue Doppler Myocardial Performance Index Correlates with Severity of Pulmonary Hypertension in Children. American Society of Echocardiography 28th Annual Scientific Session in Baltimore, MD. 2017;30(6):B27

Jone PN, Schäfer M, Bremen C, Ivy DD. Right Atrial Area is Associated with Three-Dimensional Echocardiography Volumetric and Functional Indices in Children with Pulmonary Hypertension. American Society of Echocardiography 28th Annual Scientific Session in Baltimore, MD. 2017;30(6):B32

Jone PN, Schäfer M, Bremen C, Ivy DD. Three-Dimensional Echocardiography Right Ventricular Indices Assess Disease Severity in Pediatric Pulmonary Hypertension. 7th World Congress of Pediatric Cardiology and Pediatric Cardiac Surgery in Barcelona, Spain, July 2017.

Jone PN, Wilson N, Morgan G, Ivy DD, Ross M. Three-Dimensional Echocardiographic Guidance of Right Heart Catheterization Decreases Radiation Exposure in Atrial Septal Defect Closures – poster presentation at 7th World Congress of Pediatric Cardiology and Pediatric Cardiac Surgery in Barcelona, Spain, July 2017

Jone PN, Schäfer M, Bremen C, Ivy DD. Right ventricular arterial coupling ratio correlates with right ventricular strain and predicts outcomes using three-dimensional echocardiography in pediatric pulmonary hypertension. Circulation;132:2017

Kheyfets V, Dufva M, Ivy DD, Shandas R, Truong U. Decreasing LV torsion rate causes inter-ventricular mechanical de-coupling and thereby disrupts RV function in pediatric pulmonary hypertension. Circulation;132:2017

Schäfer M, Collins KK, Browne L, Ivy DD, Abman SH, Friesen R, Frank B, Fonseca B, DiMaria M, Hunter K, Truong U, von Alvensleben J. Children with pulmonary hypertension and LV dyssynchrony have worse left ventricular function. Circulation;132:2017

Jone PN, Burkett D, Morgan G, Wilson N, Ivy DD, Ross M. Radiation reduction in atrial septal defect closures using three-dimensional echocardiographic guidance of right heart catheterization in pediatric patients – poster presentation at Euro Echo Imaging in Lisbon, Portugal December 2017

Beghetti M, Berger RM, Ivy DD, Bonnet D, Humpl T. To "Cath" or Not in Pediatric Pulmonary Hypertension?. J Am Coll Cardiol. 2016 Mar 1;67(8):1010-1. PubMed PMID: 26916495

Jone PN, Patel SS, Cassidy C, Ivy DD. Three-dimensional Echocardiography of Right Ventricular Function Correlates with Severity of Pediatric Pulmonary Hypertension. Congenit Heart Dis. 2016 Feb 22. [Epub ahead of print] PubMed PMID: 26899626

Jone PN, Schäfer M, Li L, Craft M, Ivy DD, Kutty S. Right Atrial Deformation in Predicting Outcomes in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2017 Dec;10(12). PubMed PMID: 29233835

Johnson JN, Ivy DD. The 2017 Seventh World Congress of Pediatric Cardiology & Cardiac Surgery: Week in Review: heart failure, transplantation, and pulmonary hypertension. Cardiol Young. 2017 Dec;27(10):2018-2022. PubMed PMID: 29286265

Hopper RK, Abman SH, Ivy DD. Persistent Challenges in Pediatric Pulmonary Hypertension. Chest. 2016 Jul;150(1):226-36. PubMed PMID: 26836930

Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman JR, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH. Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension. J Pediatr. 2016 Mar;170:312-4. PubMed PMID: 26703869

Beghetti M, Schulze-Neick I, Berger RM, Ivy DD, Bonnet D, Weintraub RG, Saji T, Yung D, Mallory GB, Geiger R, Berger JT, Barst RJ, Humpl T. Haemodynamic characterisation and heart catheterisation complications in children with pulmonary hypertension: Insights from the Global TOPP Registry (tracking outcomes and practice in paediatric pulmonary hypertension). Int J Cardiol. 2016 Jan 15;203:325-30. PubMed PMID: 26583838

Schäfer M, Frank BS, Ivy DD, Wilson N, Morgan GJ, Barker AJ, Browne LP, Mitchell MB, Truong U. Close look at the Potts shunt flow hemodynamics in a patient with severe pulmonary hypertension: 4D-flow MRI evaluation. J Magn Reson Imaging. 2018 Nov 19. [Epub ahead of print] PubMed PMID: 30451346

Schäfer M, Browne LP, Morgan GJ, Barker AJ, Fonseca B, Ivy DD, Mitchell MB. Reduced proximal aortic compliance and elevated wall shear stress after early repair of tetralogy of Fallot. J Thorac Cardiovasc Surg. 2018 Dec;156(6):2239-2249. PubMed PMID: 30449579

Schäfer M, Younoszai A, Truong U, Browne LP, Mitchell MB, Jaggers J, Campbell DN, Hunter KS, Ivy DD, Di Maria MV. Influence of aortic stiffness on ventricular function in patients with Fontan circulation. J Thorac Cardiovasc Surg. 2018 Oct 5. [Epub ahead of print] PubMed PMID: 30396734

Friesen RH, Twite MD, Nichols CS, Cardwell KA, Pan Z, Darst JR, Wilson N, Fagan TE, Miyamoto SD, Ivy DD. Hemodynamic response to ketamine in children with pulmonary hypertension. Paediatr Anaesth. 2016 Jan;26(1):102-8. PubMed PMID: 26564806

Zhu N, Welch CL, Wang J, Allen PM, Gonzaga-Jauregui C, Ma L, King AK, Krishnan U, Rosenzweig EB, Ivy DD, Austin ED, Hamid R, Pauciulo MW, Lutz KA, Nichols WC, Reid JG, Overton JD, Baras A, Dewey FE, Shen Y, Chung WK. Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease. Genome Med. 2018 Jul 20;10(1):56. PubMed PMID: 30029678

Berger RM, Haworth SG, Bonnet D, Dulac Y, Fraisse A, Galiè N, Ivy DD, Jaïs X, Miera O, Rosenzweig EB, Efficace M, Kusic-Pajic A, Beghetti M. FUTURE-2: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion. Int J Cardiol. 2016 Jan 1;202:52-8. PubMed PMID: 26386921

Bush D, Galambos C, Ivy DD, Abman SH, Wolter-Warmerdam K, Hickey F. Clinical Characteristics and Risk Factors for Developing Pulmonary Hypertension in Children with Down Syndrome. J Pediatr. 2018 Nov;202:212-219.e2. PubMed PMID: 30025669

Schäfer M, Wilson N, Ivy DD, Ing R, Abman S, Browne LP, Morgan G, Ross M, McLennan D, Barker AJ, Fonseca B, Di Maria M, Hunter KS, Truong U. Noninvasive wave intensity analysis predicts functional worsening in children with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H968-H977. PubMed PMID: 30004811

Dufva MJ, Truong U, Tiwari P, Ivy DD, Shandas R, Kheyfets VO. Left ventricular torsion rate and the relation to right ventricular function in pediatric pulmonary arterial hypertension. Pulm Circ. 2018 Jul-Sep;8(3):2045894018791352. PubMed PMID: 30003835

Friesen RM, Schäfer M, Ivy DD, Abman SH, Stenmark K, Browne LP, Barker AJ, Hunter KS, Truong U. Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2018 May 16. [Epub ahead of print] PubMed PMID: 29788051

Schäfer M, Truong U, Ivy DD, Fonseca B, Malone L, DiMaria M, Barker AJ, Vargas D, Hunter KS, Jone PN, Browne LP. Children with kawasaki disease present elevated stiffness of great arteries: Phase-contrast MRI study. J Magn Reson Imaging. 2018 Nov;48(5):1228-1236. PubMed PMID: 29707843

Schäfer M, Browne LP, Truong U, Jaggers JJ, Mitchell MB, Malone L, Morgan G, Chatfield K, McLennan D, Turbendian H, Vargas D, Fonseca B, DiMaria M, Shah A, Ivy MP, Barker AJ, Hunter KS, Wilson N, Ivy DD, Campbell DN. Aortic stiffness in adolescent Turner and Marfan syndrome patients. Eur J Cardiothorac Surg. 2018 Nov 1;54(5):926-932. PubMed PMID: 29684119

Schäfer M, Morgan GJ, Mitchell MB, Ross M, Barker AJ, Hunter KS, Fonseca B, DiMaria M, Vargas D, Ivy DD, Wilson N, Browne LP. Impact of different coarctation therapies on aortic stiffness: phase-contrast MRI study. Int J Cardiovasc Imaging. 2018 Sep;34(9):1459-1469. PubMed PMID: 29667078

Zhu N, Gonzaga-Jauregui C, Welch CL, Ma L, Qi H, King AK, Krishnan U, Rosenzweig EB, Ivy DD, Austin ED, Hamid R, Nichols WC, Pauciulo MW, Lutz KA, Sawle A, Reid JG, Overton JD, Baras A, Dewey F, Shen Y, Chung WK. Exome Sequencing in Children With Pulmonary Arterial Hypertension Demonstrates Differences Compared With Adults. Circ Genom Precis Med. 2018 Apr;11(4):e001887. PubMed PMID: 29631995

Kinsella JP, Steinhorn RH, Mullen MP, Hopper RK, Keller RL, Ivy DD, Austin ED, Krishnan US, Rosenzweig EB, Fineman JR, Everett AD, Hanna BD, Humpl T, Raj JU, Abman SH. The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension. J Pediatr. 2018 Jun;197:17-22. PubMed PMID: 29628412

Frank BS, Ivy DD. Diagnosis, Evaluation and Treatment of Pulmonary Arterial Hypertension in Children. Children (Basel). 2018 Mar 23;5(4). PubMed PMID: 29570688

Lee WS, Wong SY, Ivy DD, Sokol RJ. Hepatopulmonary Syndrome and Portopulmonary Hypertension in Children: Recent Advances in Diagnosis and Management. J Pediatr. 2018 May;196:14-21.e1. PubMed PMID: 29514741

Schäfer M, Collins KK, Browne LP, Ivy DD, Abman S, Friesen R, Frank B, Fonseca B, DiMaria M, Hunter KS, Truong U, von Alvensleben JC. Effect of electrical dyssynchrony on left and right ventricular mechanics in children with pulmonary arterial hypertension. J Heart Lung Transplant. 2018 Jul;37(7):870-878. PubMed PMID: 29496397

Liptzin DR, Abman SH, Giesenhagen A, Ivy DD. An Approach to Children with Pulmonary Edema at High Altitude. High Alt Med Biol. 2018 Mar;19(1):91-98. PubMed PMID: 29470103

Torok RD, Li JS, Kannankeril PJ, Atz AM, Bishai R, Bolotin E, Breitenstein S, Chen C, Diacovo T, Feltes T, Furlong P, Hanna M, Graham EM, Hsu D, Ivy DD, Murphy D, Kammerman LA, Kearns G, Lawrence J, Lebeaut B, Li D, Male C, McCrindle B, Mugnier P, Newburger JW, Pearson GD, Peiris V, Percival L, Pina M, Portman R, Shaddy R, Stockbridge NL, Temple R, Hill KD. Recommendations to Enhance Pediatric Cardiovascular Drug Development: Report of a Multi-Stakeholder Think Tank. J Am Heart Assoc. 2018 Feb 10;7(4). PubMed PMID: 29440007

Di Maria MV, Mulvahill M, Jaggers J, Ivy DD, Younoszai AK. Predictive value of presuperior cavopulmonary anastomosis cardiac catheterization at increased altitude. Congenit Heart Dis. 2018 Mar;13(2):311-318. PubMed PMID: 29431283

Schäfer M, Truong U, Browne LP, Morgan GJ, Ross M, Ing R, Hunter KS, Kheyfets VO, Abman SH, Ivy DD, Wilson N. Measuring Flow Hemodynamic Indices and Oxygen Consumption in Children with Pulmonary Hypertension: A Comparison of Catheterization and Phase-Contrast MRI. Pediatr Cardiol. 2018 Feb;39(2):268-274. PubMed PMID: 29043395

Friesen RM, Schäfer M, Burkett DA, Cassidy CJ, Ivy DD, Jone PN. Right Ventricular Tissue Doppler Myocardial Performance Index in Children with Pulmonary Hypertension: Relation to Invasive Hemodynamics. Pediatr Cardiol. 2018 Jan;39(1):98-104. PubMed PMID: 28980052

Jone PN, Schäfer M, Pan Z, Bremen C, Ivy DD. 3D echocardiographic evaluation of right ventricular function and strain: a prognostic study in paediatric pulmonary hypertension. Eur Heart J Cardiovasc Imaging. 2018 Sep 1;19(9):1026-1033. PubMed PMID: 28950335

Rosenzweig EB, Abman SH, Adatia I, Beghetti M, Bonnet D, Haworth S, Ivy DD, Berger RMF. Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management. Eur Respir J. 2018 Dec 13. [Epub ahead of print] PubMed PMID: 30545978

Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, Ross RVM, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Noordegraaf AV, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Lancet Respir Med. 2018 Dec 5. [Epub ahead of print] PubMed PMID: 30527956

Frank B, Schäfer M, Douwes JM, Ivy DD, Abman SH, Davidson JA, Burzlaff S, Mitchell MB, Morgan GJ, Browne L, Barker AJ, Truong U, Von Alvensleben JC. Novel Measures of Left Ventricular Electromechanical Discoordination Predict Clinical Outcomes in Children with Pulmonary Arterial Hypertension. Am J Physiol Heart Circ Physiol. 2019 Dec 20. [Epub ahead of print] PubMed PMID: 31858817

Geva A, Abman SH, Manzi SF, Ivy DD, Mullen MP, Griffin J, Lin C, Savova GK, Mandl KD. Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources. J Am Med Inform Assoc. 2019 Nov 26. [Epub ahead of print] PubMed PMID: 31769835

Di Maria MV, Campbell KR, Burkett DA, Younoszai AK, Landeck BF 2nd, Mertens L, Ivy DD, Hunter KS, Friedberg MK. Parameters of Right Ventricular Function Reveal Ventricular-Vascular Mismatch as Determined by Right Ventricular Stroke Work versus Pulmonary Vascular Resistance in Children with Pulmonary Hypertension. J Am Soc Echocardiogr. 2019 Dec 10. [Epub ahead of print] PubMed PMID: 31836268

Geva A, Abman SH, Manzi SF, Ivy DD, Mullen MP, Griffin J, Lin C, Savova GK, Mandl KD. Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources. J Am Med Inform Assoc. 2019 Nov 26. [Epub ahead of print] PubMed PMID: 31769835

Bush D, Wolter-Warmerdam K, Wagner BD, Galambos C, Ivy DD, Abman S, McMorrow D, Hickey F. EXPRESS: Angiogenic Profile Identifies Pulmonary Hypertension in Children with Down Syndrome. Pulm Circ. 2019 Jul 11;:2045894019866549. [Epub ahead of print] PubMed PMID: 31293212

Schäfer M, Barker AJ, Jaggers J, Morgan GJ, Stone ML, Truong U, Browne LP, Malone L, Ivy DD, Mitchell MB. Abnormal aortic flow conduction is associated with increased viscous energy loss in patients with repaired tetralogy of Fallot. Eur J Cardiothorac Surg. 2019 Sep 18. [Epub ahead of print] PubMed PMID: 31535124

Ivy DD, Feinstein JA, Yung D, Mullen MP, Kirkpatrick EC, Hirsch R, Austin ED, Fineman J, Truong U, Solum D, Deng CQ, Hopper RK. Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension. Pulm Circ. 2019 Jul-Sep;9(3):2045894019856471. PubMed PMID: 31215336

McLennan D, Ivy D, Morgan GJ. Transvenous implantation of the Occlutech Atrial Flow Regulator: Preliminary results from swine models. Congenit Heart Dis. 2019 Sep;14(5):819-831. PubMed PMID: 31328339

Beghetti M, Gorenflo M, Ivy DD, Moledina S, Bonnet D. Treatment of pediatric pulmonary arterial hypertension: A focus on the NO-sGC-cGMP pathway. Pediatr Pulmonol. 2019 Oct;54(10):1516-1526. PubMed PMID: 31313530

Bush D, Wolter-Warmerdam K, Wagner BD, Galambos C, Ivy DD, Abman S, McMorrow D, Hickey F. Angiogenic Profile Identifies Pulmonary Hypertension in Children with Down Syndrome. Pulm Circ. 2019 Jul 11;:2045894019866549. [Epub ahead of print] PubMed PMID: 31293212

Caicedo L, Hopper RK, Garcia H, Ivy DD, Haag D, Fineman J, Humpi T, Al-Tamimi O, Feinstein J, Berger RM, Berman-Rosenzweig E, Kashour T, Diaz GF, Mendoza A, Bobhate P, Handler S, Lopes AA, Barwad P, Kumar Rahit M, Krishnan U, Adatia ITK, Moledina S, Abman S, Cerro Marin MJD. EXPRESS: Acute Vasoreactivity Testing in Pediatric Idiopathic Pulmonary Arterial Hypertension: an international Survey on Current Practice. Pulm Circ. 2019 May 30;:2045894019857533. [Epub ahead of print] PubMed PMID: 31144586

Jone PN, Ivy DD. Comprehensive Noninvasive Evaluation of Right Ventricle-Pulmonary Circulation Axis in Pediatric Patients with Pulmonary Hypertension. Curr Treat Options Cardiovasc Med. 2019 Feb 9;21(1):6. PubMed PMID: 30739224

Jone PN, Schäfer M, Pan Z, Ivy DD. Right Ventricular-Arterial Coupling Ratio Derived From 3-Dimensional Echocardiography Predicts Outcomes in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019 Dec;12(1):e008176. PubMed PMID: 30632388

Ivy D, Wilson N. Tale of 2 Endothelin Receptor Antagonists in Eisenmenger Syndrome. Circulation. 2019 Jan 2;139(1):64-66. PubMed PMID: 30592659

Kanaan U, Varghese NP, Coleman RD, Huckaby J, Lawrence P, Jorgensen LO, Miller-Reed K, Day RW, Mallory GB, Ivy DD. Oral treprostinil use in children: a multicenter, observational experience. Pulm Circ. 2019 Jul-Sep;9(3):2045894019862138. PubMed PMID: 31215346

Russell S, Beghetti M, Oudiz R, Balagtas C, Zhang M, Ivy D. Effects of oral sildenafil on exercise capacity in children with pulmonary arterial hypertension: a randomised trial. Open Heart. 2019;6(2):e001149. PubMed PMID: 31908813

Ivy DD, Feinstein JA, Yung D, Mullen MP, Kirkpatrick EC, Hirsch R, Austin ED, Fineman J, Truong U, Solum D, Deng CQ, Hopper RK. Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension. Pulm Circ. 2019 Jul-Sep;9(3):2045894019856471. PubMed PMID: 31215336

Hall K, Ogawa M, Sakarovitch C, Hopper RK, Adamson GT, Hanna B, Ivy DD, Miller-Reed K, Yung D, McCarthy E, Siehr-Handler SL, Feinstein JA. Subcutaneous and Intravenous Treprostinil Pharmacokinetics in Children With Pulmonary Vascular Disease. J Cardiovasc Pharmacol. 2019 Jun;73(6):383-393. PubMed PMID: 31162247

Galambos C, Mullen MP, Shieh JT, Schwerk N, Kielt MJ, Ullmann N, Boldrini R, Stucin-Gantar I, Haass C, Bansal M, Agrawal PB, Johnson J, Peca D, Surace C, Cutrera R, Pauciulo MW, Nichols WC, Griese M, Ivy D, Abman SH, Austin ED, Danhaive O. Phenotype characterisation of TBX4 mutation and deletion carriers with neonatal and paediatric pulmonary hypertension. Eur Respir J. 2019 Aug;54(2). PubMed PMID: 31151956

Caicedo L, Hopper RK, Garcia H, Ivy DD, Haag D, Fineman J, Humpi T, Al-Tamimi O, Feinstein J, Berger RM, Berman-Rosenzweig E, Kashour T, Diaz GF, Mendoza A, Bobhate P, Handler S, Lopes AA, Barwad P, Kumar Rahit M, Krishnan U, Adatia ITK, Moledina S, Abman S, Cerro Marin MJD. Acute Vasoreactivity Testing in Pediatric Idiopathic Pulmonary Arterial Hypertension: an international Survey on Current Practice. Pulm Circ. 2019 May 30;:2045894019857533. [Epub ahead of print] PubMed PMID: 31144586

Breeman KTN, Dufva M, Ploegstra MJ, Kheyfets V, Willems TP, Wigger J, Hunter KS, Ivy DD, Berger RMF, Truong U. Right ventricular-vascular coupling ratio in pediatric pulmonary arterial hypertension: A comparison between cardiac magnetic resonance and right heart catheterization measurements. Int J Cardiol. 2019 Oct 15;293:211-217. PubMed PMID: 31109778

Ollivier C, Sun H, Amchin W, Beghetti M, Berger RMF, Breitenstein S, Garnett C, Gullberg N, Hassel P, Ivy D, Kawut SM, Klein A, Lesage C, Migdal M, Nije B, Odermarsky M, Strait J, de Graeff PA, Stockbridge N. New Strategies for the Conduct of Clinical Trials in Pediatric Pulmonary Arterial Hypertension: Outcome of a Multistakeholder Meeting With Patients, Academia, Industry, and Regulators, Held at the European Medicines Agency on Monday, June 12, 2017. J Am Heart Assoc. 2019 May 21;8(10):e011306. PubMed PMID: 31088189

Giesenhagen AM, Ivy DD, Brinton JT, Meier MR, Weinman JP, Liptzin DR. High Altitude Pulmonary Edema in Children: A Single Referral Center Evaluation. J Pediatr. 2019 Jul;210:106-111. PubMed PMID: 31005280

Beghetti M, Brand M, Berger RMF, Humpl T, Wheeler JG, Ivy DD, Bonnet D. Meaningful and feasible composite clinical worsening definitions in paediatric pulmonary arterial hypertension: An analysis of the TOPP registry. Int J Cardiol. 2019 Aug 15;289:110-115. PubMed PMID: 31072635

McLennan D, Schäfer M, Mitchell MB, Morgan GJ, Ivy D, Barker AJ, Jacobsen R. Usefulness of 4D-Flow MRI in Mapping Flow Distribution Through Failing Fontan Circulation Prior to Cardiac Intervention. Pediatr Cardiol. 2019 Jun;40(5):1093-1096. PubMed PMID: 30982076

Schäfer M, Frank BS, Humphries SM, Hunter KS, Carmody KL, Jacobsen R, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Barker AJ, Browne LP, Ivy DD, Younoszai A, Di Maria MV. Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study. Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1032-H1040. PubMed PMID: 32167782

Schäfer M, Browne LP, von Alvensleben JC, Mitchell MB, Morgan GJ, Ivy DD, Jaggers J. Ventricular interactions and electromechanical dyssynchrony after Ross and Ross-Konno operations. J Thorac Cardiovasc Surg. 2019 Aug;158(2):509-517. PubMed PMID: 30928217

Kiely DG, Levin D, Hassoun P, Ivy DD, Jone PN, Bwika J, Kawut SM, Lordan J, Lungu A, Mazurek J, Moledina S, Olschewski H, Peacock A, Puri GD, Rahaghi F, Schafer M, Schiebler M, Screaton N, Tawhai M, Van Beek EJ, Vonk-Noordegraaf A, Vanderpool RR, Wort J, Zhao L, Wild J, Vogel-Claussen J, Swift AJ. EXPRESS: Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI). Pulm Circ. 2019 Mar 18;:2045894019841990. [Epub ahead of print] PubMed PMID: 30880632

Frank BS, Schäfer M, Grenolds A, Ivy DD, Abman SH, Darst JR. Acute Vasoreactivity Testing during Cardiac Catheterization of Neonates with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension. J Pediatr. 2019 May;208:127-133. PubMed PMID: 30871795

Schäfer M, Ivy DD, Abman SH, Stenmark K, Browne LP, Barker AJ, Mitchell MB, Morgan GJ, Wilson N, Shah A, Kollengode M, Naresh N, Fonseca B, DiMaria M, Buckner JK, Hunter KS, Kheyfets V, Fenster BE, Truong U. Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies. Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1091-H1104. PubMed PMID: 30822118

Goreczny S, Ivy D, Anderson R. "The person who influenced me most was the person who disagreed most strongly with me": an interview with Professor Robert Anderson. Cardiol Young. 2019 Mar;29(3):259-262. PubMed PMID: 30793679

Jone PN, Ivy DD. Comprehensive Noninvasive Evaluation of Right Ventricle-Pulmonary Circulation Axis in Pediatric Patients with Pulmonary Hypertension. Curr Treat Options Cardiovasc Med. 2019 Feb 9;21(1):6. PubMed PMID: 30739224

Burkett DA, Patel SS, Mertens L, Friedberg MK, Ivy DD. Relationship Between Left Ventricular Geometry and Invasive Hemodynamics in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2020 May;13(5):e009825. PubMed PMID: 32408829

Frank BS, Runciman M, Manning WA, Ivy DD, Abman SH, Howley L. Pulmonary Hypertension Secondary to Scurvy in a Developmentally Typical Child. J Pediatr. 2019 May;208:291-291.e2. PubMed PMID: 30738657

Kheyfets VO, Dufva MJ, Boehm M, Tian X, Qin X, Tabakh JE, Truong U, Ivy D, Spiekerkoetter E. The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload. Physiol Rep. 2020 May;8(9):e14347. PubMed PMID: 32367677

Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Lancet Respir Med. 2019 Mar;7(3):227-238. PubMed PMID: 30527956

Simpson CE, Damico RL, Hassoun PM, Martin LJ, Yang J, Nies MK, Vaidya RD, Brandal S, Pauciulo MW, Austin ED, Ivy DD, Nichols WC, Everett AD. Noninvasive Prognostic Biomarkers for Left-Sided Heart Failure as Predictors of Survival in Pulmonary Arterial Hypertension. Chest. 2020 Jun;157(6):1606-1616. PubMed PMID: 31987881

Ivy D, Wilson N. Tale of 2 Endothelin Receptor Antagonists in Eisenmenger Syndrome. Circulation. 2019 Jan 2;139(1):64-66. PubMed PMID: 30592659

Jone PN, Schäfer M, Pan Z, Ivy DD. Right Ventricular-Arterial Coupling Ratio Derived From 3-Dimensional Echocardiography Predicts Outcomes in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2019 Dec;12(1):e008176. PubMed PMID: 30632388

Coleman RD, Chartan CA, Ivy DD. MicroRNA as a Biomarker in Pediatric Pulmonary Hypertension: A Step Closer to the Holy Grail?. Pediatr Crit Care Med. 2020 Apr;21(4):393-394. PubMed PMID: 32251186

Simpson CE, Chen JY, Damico RL, Hassoun PM, Martin LJ, Yang J, Nies M, Griffiths M, Vaidya RD, Brandal S, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD. Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension. Eur Respir J. 2020 Apr;55(4). PubMed PMID: 32029443

Avitabile CM, Vorhies EE, Ivy DD. Drug Treatment of Pulmonary Hypertension in Children. Paediatr Drugs. 2020 Apr;22(2):123-147. PubMed PMID: 31960361

Kheyfets V, Truong U, Ivy D, Shandas R. Structural and Biomechanical Adaptations of Right Ventricular Remodeling - in Pulmonary Arterial Hypertension - Reduces Left Ventricular Rotation During Contraction: A Computational Study. J Biomech Eng. 2019 Feb 4. [Epub ahead of print] PubMed PMID: 30714069

Schäfer M, Barker AJ, Morgan GJ, Jaggers J, Stone ML, Browne LP, Ivy DD, Mitchell MB. Increased systolic vorticity in the left ventricular outflow tract is associated with abnormal aortic flow formations in Tetralogy of Fallot. Int J Cardiovasc Imaging. 2020 Apr;36(4):691-700. PubMed PMID: 31907684

Rosenzweig EB, Abman SH, Adatia I, Beghetti M, Bonnet D, Haworth S, Ivy DD, Berger RMF. Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management. Eur Respir J. 2019 Jan;53(1). PubMed PMID: 30545978

Yang J, Griffiths M, Nies MK, Brandal S, Damico R, Vaidya D, Tao X, Simpson CE, Kolb TM, Mathai SC, Pauciulo MW, Nichols WC, Ivy DD, Austin ED, Hassoun PM, Everett AD. Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival. BMC Med. 2020 Oct 6;18(1):268. PubMed PMID: 33019943

Schäfer M, Frank BS, Ivy DD, Wilson N, Morgan GJ, Barker AJ, Browne LP, Mitchell MB, Truong U. Close look at the Potts shunt flow hemodynamics in a patient with severe pulmonary hypertension: 4D-flow MRI evaluation. J Magn Reson Imaging. 2019 Jun;49(6):1800-1802. PubMed PMID: 30451346

Das BB, Frank B, Ivy D. Segmental Pulmonary Hypertension in Children with Congenital Heart Disease. Medicina (Kaunas). 2020 Sep 24;56(10). PubMed PMID: 32987636

Griffiths M, Yang J, Nies M, Vaidya D, Brandal S, Williams M, Matsui EC, Grant T, Damico R, Ivy D, Austin ED, Nichols WC, Pauciulo MW, Lutz K, Rosenzweig EB, Hirsch R, Yung D, Everett AD. Pediatric pulmonary hypertension: insulin-like growth factor-binding protein 2 is a novel marker associated with disease severity and survival. Pediatr Res. 2020 Sep 14. [Epub ahead of print] PubMed PMID: 32927467

Schäfer M, Younoszai A, Truong U, Browne LP, Mitchell MB, Jaggers J, Campbell DN, Hunter KS, Ivy DD, Di Maria MV. Influence of aortic stiffness on ventricular function in patients with Fontan circulation. J Thorac Cardiovasc Surg. 2019 Feb;157(2):699-707. PubMed PMID: 30396734

Schäfer M, Browne LP, Morgan GJ, Barker AJ, Fonseca B, Ivy DD, Mitchell MB. Reduced proximal aortic compliance and elevated wall shear stress after early repair of tetralogy of Fallot. J Thorac Cardiovasc Surg. 2018 Dec;156(6):2239-2249. PubMed PMID: 30449579

Zhu N, Welch CL, Wang J, Allen PM, Gonzaga-Jauregui C, Ma L, King AK, Krishnan U, Rosenzweig EB, Ivy DD, Austin ED, Hamid R, Pauciulo MW, Lutz KA, Nichols WC, Reid JG, Overton JD, Baras A, Dewey FE, Shen Y, Chung WK. Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease. Genome Med. 2018 Jul 20;10(1):56. PubMed PMID: 30029678

Bush D, Galambos C, Ivy DD, Abman SH, Wolter-Warmerdam K, Hickey F. Clinical Characteristics and Risk Factors for Developing Pulmonary Hypertension in Children with Down Syndrome. J Pediatr. 2018 Nov;202:212-219.e2. PubMed PMID: 30025669

Jone PN, Ivy DD, Daniels SR. Pediatric Cardiology: From Basics to Innovation. Pediatr Clin North Am. 2020 Oct;67(5):xvii-xviii. PubMed PMID: 32888696

Schäfer M, Wilson N, Ivy DD, Ing R, Abman S, Browne LP, Morgan G, Ross M, McLennan D, Barker AJ, Fonseca B, Di Maria M, Hunter KS, Truong U. Noninvasive wave intensity analysis predicts functional worsening in children with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H968-H977. PubMed PMID: 30004811

Frank BS, Ivy DD. Pediatric Pulmonary Arterial Hypertension. Pediatr Clin North Am. 2020 Oct;67(5):903-921. PubMed PMID: 32888689

Schäfer M, Frank BS, Jacobsen R, Rausch CM, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Browne LP, Barker AJ, Hunter KS, Ivy DD, Younoszai A, Di Maria MV. Patients with Fontan circulation have abnormal aortic wave propagation patterns: A wave intensity analysis study. Int J Cardiol. 2020 Aug 25. [Epub ahead of print] PubMed PMID: 32853667

Dufva MJ, Truong U, Tiwari P, Ivy DD, Shandas R, Kheyfets VO. Left ventricular torsion rate and the relation to right ventricular function in pediatric pulmonary arterial hypertension. Pulm Circ. 2018 Jul-Sep;8(3):2045894018791352. PubMed PMID: 30003835

Vanderlaan RD, Rome J, Hirsch R, Ivy D, Caldarone CA. Pulmonary vein stenosis: Treatment and challenges. J Thorac Cardiovasc Surg. 2020 Jun 27. [Epub ahead of print] PubMed PMID: 32763037

Friesen RM, Schäfer M, Ivy DD, Abman SH, Stenmark K, Browne LP, Barker AJ, Hunter KS, Truong U. Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2019 Feb 1;20(2):209-217. PubMed PMID: 29788051

Schäfer M, Ivy DD, Barker AJ, Mitchell MB. Reply to Commentary: Can't flow down: More 4-dimensional flow magnetic resonance imaging studies are needed in congenital heart disease. J Thorac Cardiovasc Surg. 2020 Oct;160(4):1019-1020. PubMed PMID: 32739168

Chen JY, Griffiths M, Yang J, Nies MK, Damico RL, Simpson CE, Vaidya RD, Brandal S, Ivy DD, Austin ED, Nichols WC, Pauciulo MW, Lutz K, Rosenzweig EB, Hirsch R, Yung D, Everett AD. Elevated Interleukin-6 Levels Predict Clinical Worsening in Pediatric Pulmonary Arterial Hypertension. J Pediatr. 2020 Aug;223:164-169.e1. PubMed PMID: 32711743

Schäfer M, Bjornstad P, Frank BS, Baumgartner A, Truong U, Enge D, von Alvensleben JC, Mitchell MB, Ivy DD, Barker AJ, Reusch JEB, Nadeau KJ. Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study). Am J Cardiol. 2020 Aug 1;128:45-53. PubMed PMID: 32650923

Naresh NK, Schäfer M, Browne L, Ivy DD, Zimmerman D, Kheyfets V, Barker AJ, Truong U. Non-Invasive Evaluation of Inhaled Nitric Oxide on Pulmonary Blood Flow Dynamics using 4D Flow MRI in Pediatric Pulmonary Arterial Hypertension Patients. P352. Society of Cardiac MRI, Seattle, WA, 2019

Ivy D. The failing right ventricle: Where do we go from here. Acta Physiol (Oxf). 2020 Aug;229(4):e13523. PubMed PMID: 32562585

Zimmerman D, Douwes MJ, Schäfer M, Ivy DD, Abman SH, Barker AJ, Naresh NK, Kheyfets V, Truong U. Non-Invasive Wave Intensity Analysis by Phase-Contrast MRI Correlates with Mean Pulmonary Artery Pressure Before and After Nitric Oxide Testing in Children with Pulmonary Arterial Hypertension. Society of Cardiac MRI, Seattle, WA, 2019

Sehgal A, Steenhorst JJ, Mclennan DI, Merkus D, Ivy D, McNamara PJ. The Left Heart, Systemic Circulation, and Bronchopulmonary Dysplasia: Relevance to Pathophysiology and Therapeutics. J Pediatr. 2020 Oct;225:13-22.e2. PubMed PMID: 32553872

Frank B, Schäfer M, Ivy DD, Jone PN. Echocardiography-derived fractional right atrial area change outperforms catheterization-derived hemodynamics to predict risk of adverse events in pediatric pulmonary hypertension. Pulmonary Circulation 2019; 8(3): 9.

Schäfer M, Frank B, Ivy DD, Abman SH, Browne LP, Mitchell MB, Barker AJ, Truong U. Children with pulmonary arterial hypertension have abnormal left ventricular inflow dynamics with increased flow retention. Pulmonary Circulation 2019; 8(3): 9

Burkett DA, Patel SS, Mertens L, Friedberg MK, Ivy DD. Relationship Between Left Ventricular Geometry and Invasive Hemodynamics in Pediatric Pulmonary Hypertension. Circ Cardiovasc Imaging. 2020 May;13(5):e009825. PubMed PMID: 32408829

Hopper RK, Ivy DD, Yung D, Mullen MP, Hanna BD, Kirkpatrick E, Hirsch R, Austin ED, Fineman J, Solum D, Deng CQ, Feinstein JA. Pharmacokinetics of Oral Treprostinil in Children With Pulmonary Arterial Hypertension. J Cardiovasc Pharmacol. 2020 Jul;76(1):94-100. PubMed PMID: 32398473

Kheyfets VO, Dufva MJ, Boehm M, Tian X, Qin X, Tabakh JE, Truong U, Ivy D, Spiekerkoetter E. The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload. Physiol Rep. 2020 May;8(9):e14347. PubMed PMID: 32367677

Jone PN, Duchateau N, Pan X, Ivy DD, Moceri P. Three-dimensional right ventricular strain in Pediatric Pulmonary Hypertension. American College of Cardiology, New Orleans, LA. 2019:1142-481

Frank BS, Schafer M, Thomas TM, Haxel C, Ivy DD, Jone PN. Right Atrial Conduit Phase Emptying Predicts Risk of Adverse Events in Pediatric Pulmonary Arterial Hypertension. J Am Soc Echocardiogr. 2020 Aug;33(8):1006-1013. PubMed PMID: 32336608

Coleman RD, Chartan CA, Ivy DD. MicroRNA as a Biomarker in Pediatric Pulmonary Hypertension: A Step Closer to the Holy Grail?. Pediatr Crit Care Med. 2020 Apr;21(4):393-394. PubMed PMID: 32251186

Yang J, Nies M, Griffiths M, Damico R, Vaidya D, Brandl S, Pauciulio M, Austin E, Ivy DD, Nichols W, Everett A. Hepatoma-Derived Growth Factor is a Predictor of Disease Severity and Survival in Pulmonary Arterial Hypertension and Highly Associated with Portal Pulmonary Hypertension. Am J Respir Crit Care Med: A2521, 2019

Schäfer M, Frank BS, Humphries SM, Hunter KS, Carmody KL, Jacobsen R, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Barker AJ, Browne LP, Ivy DD, Younoszai A, Di Maria MV. Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study. Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1032-H1040. PubMed PMID: 32167782

Simpson C, Damico R, Hassoun P, Yang J, Nies M, Griffiths M, Vaidya D, Brandl S, Pauciulio M, Austin E, Ivy DD, Nichols W, Everett A. Circulating serum ST2 as a biomarker of Disease Severity and Survival in Pulmonary Arterial. Am J Respir Crit Care Med: A4396, 2019

Simpson CE, Chen JY, Damico RL, Hassoun PM, Martin LJ, Yang J, Nies M, Griffiths M, Vaidya RD, Brandal S, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD. Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension. Eur Respir J. 2020 Apr;55(4). PubMed PMID: 32029443

Simpson CE, Damico RL, Hassoun PM, Martin LJ, Yang J, Nies MK, Vaidya RD, Brandal S, Pauciulo MW, Austin ED, Ivy DD, Nichols WC, Everett AD. Noninvasive Prognostic Biomarkers for Left-Sided Heart Failure as Predictors of Survival in Pulmonary Arterial Hypertension. Chest. 2020 Jun;157(6):1606-1616. PubMed PMID: 31987881

Avitabile CM, Vorhies EE, Ivy DD. Drug Treatment of Pulmonary Hypertension in Children. Paediatr Drugs. 2020 Apr;22(2):123-147. PubMed PMID: 31960361

Bush D, McMorrow D, Wagner B, Galambos C, Ivy DD, Abman S, Hickey F. Angiogenic Profile Identifies Pulmonary Hypertension in Down Syndrome. Am J Respir Crit Care Med: A4404, 2019

Schäfer M, Browne LP, Jaggers J, Barker AJ, Morgan GJ, Ivy DD, Mitchell MB. Abnormal left ventricular flow organization following repair of tetralogy of Fallot. J Thorac Cardiovasc Surg. 2020 Oct;160(4):1008-1015. PubMed PMID: 31924354

Hong N, Ivy DD, Lai J, Frank B, Grenolds A, Stillwell P,Houin P. It’s Not the Heart. An Unusual Case of Medium Vessel Vasculitis and Pulmonary Hypertension. Am J Respir Crit Care Med: A4959, 2019

Schäfer M, Barker AJ, Morgan GJ, Jaggers J, Stone ML, Browne LP, Ivy DD, Mitchell MB. Increased systolic vorticity in the left ventricular outflow tract is associated with abnormal aortic flow formations in Tetralogy of Fallot. Int J Cardiovasc Imaging. 2020 Apr;36(4):691-700. PubMed PMID: 31907684

Yang J, Griffiths M, Nies M, Damico R, Vaidya D, Pauciulio M, Nichols W, Ivy DD, Austin E, Everett A. Identification of Insulin-Like Growth Factor Binding Protein-2 as a Novel Biomarker of Pulmonary Arterial Hypertension Severity and Survival. Am J Respir Crit Care Med: A5048, 2019

Jone PN, Duchateau N, Pan Z, Ivy DD, Moceri P. Three-Dimensional Right Ventricular Global and Regional Strain Predict Outcomes in Pediatric Pulmonary Hypertension. American Society of Echocardiography 30th Annual Scientific Session in Portland, Oregon, JASE 2019;32(6): B24

Cassidy C, Schäfer M, Burkett D, Ivy DD, Jone PN. Comparison of Right Atrial and Ventricular Strain During Simultaneous Vasoreactivity Testing in Pediatric Pulmonary Hypertension. American Society of Echocardiography 30thAnnual Scientific Session in Portland, Oregon, JASE 2019;32(6): B28

Frank B, Schäfer M, Ivy DD, Jone PN. Decreased Reliance on Right Atrial Contraction for Atrial Emptying Predicts Decreased Risk of Adverse Events in Pediatric Pulmonary Hypertension. American Society of Echocardiography 30th Annual Scientific Session in Portland, Oregon, JASE 2019;32(6): B8

Frank BS, Schäfer M, Douwes JM, Ivy DD, Abman SH, Davidson JA, Burzlaff S, Mitchell MB, Morgan GJ, Browne LP, Barker AJ, Truong U, von Alvensleben JC. Novel measures of left ventricular electromechanical discoordination predict clinical outcomes in children with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2020 Feb 1;318(2):H401-H412. PubMed PMID: 31858817

Frank BS, Lewis K, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Twite M, Ivy DD, Di Maria MV, Klawitter J, Davidson JA. Endothelin-1 Activation Is Associated With Post-Operative Hypoxemia in Infants with Single Ventricle Heart Disease Undergoing Superior Cavo-Pulmonary Anastomosis. 4th European Conference on Neonatal and Paediatric Pulmonary Vascular Disease, Groningen, NL, 2019

Ivy DD, Rosenzweig EB, Elliott CG, Farber HW, Frantz RP, Gomberg-Maitland M,Mu Y, Zhao C, Kenny E, Selej M, Benza RL. Risk Assessment in Pediatric Patients with Pulmonary Arterial Hypertension (PAH): Application of the REVEAL 2.0 Risk Calculator. CHEST, Vol. 156, Issue 4, A169–A171

Di Maria MV, Campbell KR, Burkett DA, Younoszai AK, Landeck BF 2nd, Mertens L, Ivy DD, Hunter KS, Friedberg MK. Parameters of Right Ventricular Function Reveal Ventricular-Vascular Mismatch as Determined by Right Ventricular Stroke Work versus Pulmonary Vascular Resistance in Children with Pulmonary Hypertension. J Am Soc Echocardiogr. 2020 Feb;33(2):218-225. PubMed PMID: 31836268

Geva A, Abman SH, Manzi SF, Ivy DD, Mullen MP, Griffin J, Lin C, Savova GK, Mandl KD. Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources. J Am Med Inform Assoc. 2020 Feb 1;27(2):294-300. PubMed PMID: 31769835

Schäfer M, Barker AJ, Jaggers J, Morgan GJ, Stone ML, Truong U, Browne LP, Malone L, Ivy DD, Mitchell MB. Abnormal aortic flow conduction is associated with increased viscous energy loss in patients with repaired tetralogy of Fallot. Eur J Cardiothorac Surg. 2020 Mar 1;57(3):588-595. PubMed PMID: 31535124

Berger RMF, Beghetti M, Bonnet D, Humpl T, Ivy DD. Pulmonary hypertension in childhood: long-term survival of newly diagnosed patients in the current treatment era. Results from the TOPP-1 registry. AEPC, 2020, abstract ID 27485

Humpl T, Bonnet D, Ivy DD, Berger RMF, Beghetti M for the TOPP investigators. Classification of congenital heart disease associated with pulmonary arterial hypertension (PAH-CHD) within the TOPP registry. AEPC 2020, abstract ID 27161

Apitz C, Ivy DD, Berger RMF, Humpl T, Bonnet D, Beghetti M, Schranz D, Latus H on behalf of the TOPP investigators. Impact of diastolic pulmonary arterial pressure on prognostic assessment in children with pulmonary arterial hypertension. AEPC 2020

Jone PN, Cassidy C, Ivy DD. RV-PA coupling ratio using TAPSE/PAAT is not a reliable measure of severity of pediatric pulmonary hypertension. PVRI, Lima, Peru, 2020

Issapour A, Crook S, Hite M, Rosenzweig EB, Frank B, Ivy D, Krishnan U. Safety and efficacy of combination therapy with ambrisentan and tadalafil for the treatment of pulmonary arterial hypertension in children: early experience. PVRI, Lima, Peru, 2020

Giesenhagen A, Ivy DD, Brinton J, Meier M, Weinmann J, Liptzin D. Sex differences in pediatric HAPE. PVRI, Lima, Peru, 2020

Frank BS, Schafer M, Thomas TM, Ivy DD, Jone PN. Longitudinal Assessment of Right Atrial Conduit Fraction Provides Additional Insight into Likelihood of Adverse Events in Pediatric Pulmonary Hypertension - Rapid fire oral presentation - American Society of Echocardiography 31th Annual Scientific Session in Denver, Colorado, June 2020

Sun H, Ivy DD, Stockbridge N, Handler S, Bates A, Krishnan U, Yung D, Hopper R, Fineman J, Austin E, Mullen M. Utilizing Actigraphy to Measure Impact of Genetic Mutations on Heart Rate Variability in Pediatric Pulmonary Hypertension. Am J Respir Crit Care Med: A3773, 2020

Le L, Ivy DD, Jone PN. Right Ventricular Strain Comparison Between Quantification Software in Pediatric Normal and Pulmonary Hypertension Patients – poster presentation at American Heart Association Scientific Session, November 2020

Ivy D, Frank BS. Update on pediatric pulmonary arterial hypertension. Curr Opin Cardiol. 2020 Oct 29. [Epub ahead of print] PubMed PMID: 33136663

Jone PN, Duchateau N, Pan Z, Ivy DD, Moceri P. Right ventricular area strain from 3-dimensional echocardiography: Mechanistic insight of right ventricular dysfunction in pediatric pulmonary hypertension. J Heart Lung Transplant. 2020 Nov 15. [Epub ahead of print] PubMed PMID: 33268039

Fakhri S, Hannon K, Moulden K, Peterson R, Hountras P, Bull T, Maloney J, De Marco T, Ivy D, Thenappan T, Sager JS, Ryan JJ, Mazimba S, Hirsch R, Chakinala M, Shlobin O, Lammi M, Zwicke D, Robinson J, Benza RL, Klinger J, Grinnan D, Mathai S, Badesch D. Residence at moderately high altitude and its relationship with WHO Group 1 pulmonary arterial hypertension symptom severity and clinical characteristics: the Pulmonary Hypertension Association Registry. Pulm Circ. 2020 Oct-Dec;10(4):2045894020964342. PubMed PMID: 33240488

Truong U, Meinel K, Haddad F, Koestenberger M, Carlsen J, Ivy D, Jone PN. Update on noninvasive imaging of right ventricle dysfunction in pulmonary hypertension. Cardiovasc Diagn Ther. 2020 Oct;10(5):1604-1624. PubMed PMID: 33224776

Griffiths M, Yang J, Vaidya D, Nies M, Brandal S, Ivy DD, Hickey F, Wolter-Warmerdam K, Austin ED, Mullen M, Pauciulo MW, Lutz KA, Rosenzweig EB, Hirsch R, Yung D, Nichols WC, Everett AD. Biomarkers of Pulmonary Hypertension Are Altered in Children With Down Syndrome and Pulmonary Hypertension. J Pediatr. 2021 Oct 20. [Epub ahead of print] PubMed PMID: 34687693

Simpson CE, Griffiths M, Yang J, Nies MK, Vaidya RD, Brandal S, Martin LJ, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD, Hassoun PM, Damico RL. The angiostatic peptide endostatin enhances mortality risk prediction in pulmonary arterial hypertension. ERJ Open Res. 2021 Oct;7(4). PubMed PMID: 34651041

Daly CM, Griffiths M, Simpson CE, Yang J, Damico RL, Vaidya RD, Williams M, Brandal S, Jone PN, Polsen C, Ivy DD, Austin ED, Nichols WC, Pauciulo MW, Lutz K, Nies MK, Rosenzweig EB, Hirsch R, Yung D, Everett AD. Angiostatic Peptide, Endostatin, Predicts Severity in Pediatric Congenital Heart Disease-Associated Pulmonary Hypertension. J Am Heart Assoc. 2021 Oct 19;10(20):e021409. PubMed PMID: 34622662

Dufva MJ, Ivy D, Campbell K, Lam A, Rauff A, Breeman KTN, Douwes JM, Berger RMF, Kheyfets VO, Hunter K. Ventricular-vascular coupling is predictive of adverse clinical outcome in paediatric pulmonary arterial hypertension. Open Heart. 2021 Sep;8(2). PubMed PMID: 34583983

Diaz GF, Marquez A, Ruiz-Parra A, Beghetti M, Ivy D. An Acute Hyperoxia Test Predicts Survival in Children with Pulmonary Hypertension Living at High Altitude. High Alt Med Biol. 2021 Dec;22(4):395-405. PubMed PMID: 34905397

Apitz C, Berger RMF, Ivy DD, Humpl T, Bonnet D, Beghetti M, Schranz D, Latus H. Hemodynamic and prognostic impact of the diastolic pulmonary arterial pressure in children with pulmonary arterial hypertension-a registry-based analysis. Cardiovasc Diagn Ther. 2021 Aug;11(4):1037-1047. PubMed PMID: 34527529

Grady RM, Canter MW, Wan F, Shmalts AA, Coleman RD, Beghetti M, Berger RMF, Del Cerro Marin MJ, Fletcher SE, Hirsch R, Humpl T, Ivy DD, Kirkpatrick EC, Kulik TJ, Levy M, Moledina S, Yung D, Eghtesady P, Bonnet D. Pulmonary-to-Systemic Arterial Shunt to Treat Children With Severe Pulmonary Hypertension. J Am Coll Cardiol. 2021 Aug 3;78(5):468-477. PubMed PMID: 34325836

Schäfer M, Frank BS, Grady RM, Eghtesady P, Mitchell MB, Jaggers J, Ivy DD. Monitoring and evaluation of the surgical Potts shunt physiology using 4-dimensional flow magnetic resonance imaging. J Thorac Cardiovasc Surg. 2021 Nov 16. [Epub ahead of print] PubMed PMID: 34872760

Ivy D, Bonnet D, Berger R, Meyer GMB, Baygani S, Li B. Efficacy and safety of tadalafil in a pediatric population with pulmonary arterial hypertension: phase 3 randomized, double-blind placebo-controlled study. Pulm Circ. 2021 Jul-Sep;11(3):20458940211024955. PubMed PMID: 34234945

Issapour A, Frank B, Crook S, Hite MD, Dorn ML, Rosenzweig EB, Ivy DD, Krishnan US. Safety and Tolerability of Combination Therapy with Ambrisentan and Tadalafil for the Treatment of Pulmonary Arterial Hypertension in Children: Real-World Experience. Pediatr Pulmonol. 2021 Dec 17. [Epub ahead of print] PubMed PMID: 34921523

Beghetti M, Berger RMF, Bonnet D, Grill S, Lesage C, Lemarie JC, Ivy DD. Echocardiographic Changes and Long-Term Clinical Outcomes in Pediatric Patients With Pulmonary Arterial Hypertension Treated With Bosentan for 72 Weeks: A Post-hoc Analysis From the FUTURE 3 Study. Front Pediatr. 2021;9:681538. PubMed PMID: 34222150

Douwes JM, Zijlstra WM, Rosenzweig EB, Ploegstra MJ, Krishnan US, Haarman MG, Roofthooft MTR, Postmus D, Hillege HL, Ivy DD, Berger RMF. Parenteral Prostanoids in Pediatric Pulmonary Arterial Hypertension: Start Early, Dose High, Combine. Ann Am Thorac Soc. 2021 Jun 28. [Epub ahead of print] PubMed PMID: 34181866

DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ. Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry. Pulm Circ. 2021 Jul-Sep;11(3):20458940211020913. PubMed PMID: 34158918

Maia PD, Gien J, Kinsella JP, Zablah J, Morgan G, Ivy DD, Abman SH, Frank BS. Hemodynamic Characterization of Neonates with Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension by Cardiac Catheterization. J Pediatr. 2022 Dec 1. [Epub ahead of print] PubMed PMID: 36463937

Abman SH, Mullen MP, Sleeper LA, Austin ED, Rosenzweig EB, Kinsella JP, Ivy D, Hopper RK, Usha Raj J, Fineman J, Keller RL, Bates A, Krishnan US, Avitabile CM, Davidson A, Natter MD, Mandl KD. Characterisation of Pediatric Pulmonary Hypertensive Vascular Disease from the PPHNet Registry. Eur Respir J. 2021 Jun 17. [Epub ahead of print] PubMed PMID: 34140292

García Aguilar H, Gorenflo M, Ivy DD, Moledina S, Castaldi B, Ishida H, Czesniewicz P, Kusa J, Miera O, Pattathu J, Weng KP, Ablonczy L, Apitz C, Katona M, Kurosaki K, Pulido T, Yamagishi H, Yasuda K, Cisternas G, Goth M, Lippert S, Radomskyj A, Saleh S, Willmann S, Wirsching G, Bonnet D, Beghetti M. Riociguat in children with pulmonary arterial hypertension: The PATENT-CHILD study. Pulm Circ. 2022 Jul;12(3):e12133. PubMed PMID: 36186721

Schäfer M, Ivy DD, Nguyen K, Boncella K, Frank BS, Morgan GJ, Miller-Reed K, Truong U, Colvin K, Yeager ME. Metalloproteinases and their inhibitors are associated with pulmonary arterial stiffness and ventricular function in pediatric pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H242-H252. PubMed PMID: 34085841

Hopper RK, Abman SH, Elia EG, Avitabile CM, Yung D, Mullen MP, Austin ED, Bates A, Handler SS, Feinstein JA, Ivy DD, Kinsella JP, Mandl KD, Raj JU, Sleeper LA. Pulmonary hypertension in children with down syndrome: Results from the pediatric pulmonary hypertension network registry. J Pediatr. 2022 Aug 24. [Epub ahead of print] PubMed PMID: 36027975

Dufva MJ, Boehm M, Ichimura K, Truong U, Qin X, Tabakh J, Hunter KS, Ivy D, Spiekerkoetter E, Kheyfets VO. Pulmonary arterial banding in mice may be a suitable model for studies on ventricular mechanics in pediatric pulmonary arterial hypertension. J Cardiovasc Magn Reson. 2021 Jun 3;23(1):66. PubMed PMID: 34078382

Oganesyan A, Hoffner-Heinike A, Barker AJ, Frank BS, Ivy DD, Hunter KS, Mitchell MB, Humphries SM, Fenster BE, Schäfer M. Abnormal pulmonary flow is associated with impaired right ventricular coupling in patients with COPD. Int J Cardiovasc Imaging. 2021 Oct;37(10):3039-3048. PubMed PMID: 34021434

Schäfer M, Frank BS, Ivy DD, Abman SH, Stenmark KR, Mitchell MB, Browne LP, Barker AJ, Hunter KS, Kheyfets V, Miller-Reed K, Ing R, Morgan GJ, Truong U. Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension. J Am Heart Assoc. 2021 Apr 20;10(8):e020548. PubMed PMID: 33821682

Schäfer M, Di Maria MV, Jaggers J, Stone ML, Ivy DD, Barker AJ, Mitchell MB. High-degree Norwood neoaortic tapering is associated with abnormal flow conduction and elevated flow-mediated energy loss. J Thorac Cardiovasc Surg. 2021 Feb 4. [Epub ahead of print] PubMed PMID: 33653609

Nawaytou H, Fineman JR, Moledina S, Ivy D, Abman SH, Cerro MJD. Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers. Pulm Circ. 2021 Jan-Mar;11(1):2045894021991446. PubMed PMID: 33623667

Griffiths M, Yang J, Simpson CE, Vaidya D, Nies M, Brandal S, Damico R, Ivy DD, Austin ED, Pauciulo MW, Lutz KA, Rosenzweig EB, Hirsch R, Yung D, Nichols WC, Everett AD. ST2 Is a Biomarker of Pediatric Pulmonary Arterial Hypertension Severity and Clinical Worsening. Chest. 2021 Jul;160(1):297-306. PubMed PMID: 33609516

McLennan D, Schäfer M, Barker AJ, Mitchell MB, Ing RJ, Browne LP, Ivy DD, Morgan GJ. Abnormal flow conduction through pulmonary arteries is associated with right ventricular volume and function in patients with repaired tetralogy of Fallot: does flow quality affect afterload?. Eur Radiol. 2022 Jul 19. [Epub ahead of print] PubMed PMID: 35852579

Frank BS, Schäfer M, Thomas TM, Ivy DD, Jone PN. Longitudinal assessment of right atrial conduit fraction provides additional insight to predict adverse events in pediatric pulmonary hypertension. Int J Cardiol. 2021 Apr 15;329:242-245. PubMed PMID: 33400972

Jone PN, Duchateau N, Pan Z, Ivy DD, Moceri P. Right ventricular area strain from 3-dimensional echocardiography: Mechanistic insight of right ventricular dysfunction in pediatric pulmonary hypertension. J Heart Lung Transplant. 2021 Feb;40(2):138-148. PubMed PMID: 33268039

Simpson CE, Griffiths M, Yang J, Nies MK, Vaidya D, Brandal S, Martin LJ, Pauciulo MW, Lutz KA, Coleman AW, Austin ED, Ivy DD, Nichols WC, Everett AD, Hassoun PM, Damico RL. COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study. ERJ Open Res. 2022 Apr;8(2). PubMed PMID: 35769420

Ivy D, Frank BS. Update on pediatric pulmonary arterial hypertension. Curr Opin Cardiol. 2021 Jan;36(1):67-79. PubMed PMID: 33136663

Weinman JP, Mong DA, Malone LJ, Ivy DD, Deterding RR, Galambos C. Chest computed tomography findings of ground-glass nodules with enhancing central vessel/nodule in pediatric patients with BMPR2 mutations and plexogenic arteriopathy. Pediatr Radiol. 2022 Dec;52(13):2549-2556. PubMed PMID: 35689704

Schäfer M, Frank BS, Jacobsen R, Rausch CM, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Browne LP, Barker AJ, Hunter KS, Ivy DD, Younoszai A, Di Maria MV. Patients with Fontan circulation have abnormal aortic wave propagation patterns: A wave intensity analysis study. Int J Cardiol. 2021 Jan 1;322:158-167. PubMed PMID: 32853667

Nies MK, Yang J, Griffiths M, Damico R, Zhu J, Vaydia D, Fu Z, Brandal S, Austin ED, Ivy DD, Hassoun PM, Van Eyk JE, Everett AD. Proteomics discovery of pulmonary hypertension biomarkers: Insulin-like growth factor binding proteins are associated with disease severity. Pulm Circ. 2022 Apr;12(2):e12039. PubMed PMID: 35514776

Vanderlaan RD, Rome J, Hirsch R, Ivy D, Caldarone CA. Pulmonary vein stenosis: Treatment and challenges. J Thorac Cardiovasc Surg. 2021 Jun;161(6):2169-2176. PubMed PMID: 32763037

Yang J, Ambade AS, Nies M, Griffiths M, Damico R, Vaidya D, Brandal S, Pauciulo MW, Lutz KA, Coleman AW, Nichols WC, Austin ED, Ivy D, Hassoun PM, Everett AD. Hepatoma-derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival. Pulm Circ. 2022 Jan;12(1):e12007. PubMed PMID: 35506100

Kelly TD, Meier M, Weinman JP, Ivy D, Brinton JT, Liptzin DR. High-Altitude Pulmonary Edema in Colorado Children: A Cross-Sectional Survey and Retrospective Review. High Alt Med Biol. 2022 Jun;23(2):119-124. PubMed PMID: 35384735

Schäfer M, Frank BS, Ivy DD, Mitchell MB, Collins KK, Jone PN, von Alvensleben JC. Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension. J Am Heart Assoc. 2022 Mar 15;11(6):e024787. PubMed PMID: 35229614

Zablah JE, O'Callaghan B, Shorofsky M, Ivy D, Morgan GJ. Technical Feasibility on the Use of Optical Coherence Tomography in the Evaluation of Pediatric Pulmonary Venous Stenosis. Pediatr Cardiol. 2022 Jun;43(5):1054-1063. PubMed PMID: 35037988

Domingo LT, Ivy DD, Abman SH, Grenolds AM, MacLean JT, Breaux JA, Minford KJ, Frank BS. Novel use of riociguat in infants with severe pulmonary arterial hypertension unable to wean from inhaled nitric oxide. Front Pediatr. 2022;10:1014922. PubMed PMID: 36533232

Bush DS, Ivy DD. Pulmonary Hypertension in the Population with Down Syndrome. Cardiol Ther. 2022 Mar;11(1):33-47. PubMed PMID: 35037192

DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ. Erratum: Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: An analysis of the Pulmonary Hypertension Association Registry. Pulm Circ. 2022 Oct;12(4):e12172. PubMed PMID: 36540874

Ucrós S, Aparicio C, Castro-Rodriguez JA, Ivy D. HIGH ALTITUDE PULMONARY EDEMA IN CHILDREN: A SYSTEMATIC REVIEW. Pediatr Pulmonol. 2022 Dec 23. [Epub ahead of print] PubMed PMID: 36562650

Issapour A, Frank B, Crook S, Hite MD, Dorn ML, Rosenzweig EB, Ivy DD, Krishnan US. Safety and tolerability of combination therapy with ambrisentan and tadalafil for the treatment of pulmonary arterial hypertension in children: Real-world experience. Pediatr Pulmonol. 2022 Mar;57(3):724-733. PubMed PMID: 34921523

Diaz GF, Marquez A, Ruiz-Parra A, Beghetti M, Ivy D. An Acute Hyperoxia Test Predicts Survival in Children with Pulmonary Hypertension Living at High Altitude. High Alt Med Biol. 2021 Dec;22(4):395-405. PubMed PMID: 34905397

Schäfer M, Frank BS, Grady RM, Eghtesady P, Mitchell MB, Jaggers J, Ivy DD. Monitoring and evaluation of the surgical Potts shunt physiology using 4-dimensional flow magnetic resonance imaging. J Thorac Cardiovasc Surg. 2022 Aug;164(2):331-341. PubMed PMID: 34872760

Griffiths M, Yang J, Vaidya D, Nies M, Brandal S, Ivy DD, Hickey F, Wolter-Warmerdam K, Austin ED, Mullen M, Pauciulo MW, Lutz KA, Rosenzweig EB, Hirsch R, Yung D, Nichols WC, Everett AD. Biomarkers of Pulmonary Hypertension Are Altered in Children with Down Syndrome and Pulmonary Hypertension. J Pediatr. 2022 Feb;241:68-76.e3. PubMed PMID: 34687693

Douwes JM, Zijlstra WMH, Rosenzweig EB, Ploegstra MJ, Krishnan US, Haarman MG, Roofthooft MTR, Postmus D, Hillege HL, Ivy DD, Berger RMF. Parenteral Prostanoids in Pediatric Pulmonary Arterial Hypertension: Start Early, Dose High, Combine. Ann Am Thorac Soc. 2022 Feb;19(2):227-237. PubMed PMID: 34181866

Cain MT, Schäfer M, Park S, Barker AJ, Vargas D, Stenmark KR, Yu YA, Bull TM, Ivy DD, Hoffman JRH. Characterization of pulmonary arterial stiffness using cardiac MRI. Int J Cardiovasc Imaging. 2023 Oct 30. [Epub ahead of print] PubMed PMID: 37902921

Torres G, Lancaster AC, Yang J, Griffiths M, Brandal S, Damico R, Vaidya D, Simpson CE, Martin LJ, Pauciulo MW, Nichols WC, Ivy DD, Austin ED, Hassoun PM, Everett AD. Low-affinity insulin-like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival. Pulm Circ. 2023 Jul;13(3):e12284. PubMed PMID: 37674873

Avitabile CM, Yung D, Handler S, Hopper RK, Fineman J, Freire G, Varghese N, Mullen MP, Krishnan US, Austin E, Silveira L, Ivy DD. Measurement of Physical Activity by Actigraphy in Infants and Young Children with Pulmonary Arterial Hypertension. J Pediatr. 2023 Jul 28;262:113639. PubMed PMID: 37517653

Schäfer M, Mitchell MB, Brateng C, Ivy DD, Hunter KS, Nash DB, von Alvensleben JC. Extraction and Digitization of ECG Signals from Standard Clinical Portable Document Format Files for the Principal Component Analysis of T-wave Morphology. Cardiovasc Eng Technol. 2023 Oct;14(5):631-639. PubMed PMID: 37491551

Schäfer M, Mitchell MB, Frank BS, Barker AJ, Stone ML, Jaggers J, von Alvensleben JC, Hunter KS, Friesen RM, Ivy DD, Jacobsen R, Di Maria MV. Myocardial strain-curve deformation patterns after Fontan operation. Sci Rep. 2023 Jul 24;13(1):11912. PubMed PMID: 37488167

Ta HT, Critser PJ, Schäfer M, Ollberding NJ, Taylor MD, Di Maria MV, Hirsch R, Ivy DD, Frank BS. Ventricular global function index is associated with clinical outcomes in pediatric pulmonary hypertension. J Cardiovasc Magn Reson. 2023 Jul 3;25(1):39. PubMed PMID: 37400886

Jone PN, Ivy DD, Hauck A, Karamlou T, Truong U, Coleman RD, Sandoval JP, Del Cerro Marín MJ, Eghtesady P, Tillman K, Krishnan US. Pulmonary Hypertension in Congenital Heart Disease: A Scientific Statement From the American Heart Association. Circ Heart Fail. 2023 Jul;16(7):e00080. PubMed PMID: 37357777

Torres G, Yang J, Griffiths M, Brandal S, Damico R, Vaidya D, Simpson CE, Pauciulo MW, Nichols WC, Ivy DD, Austin ED, Hassoun PM, Everett AD. Insulin-like growth factor binding Protein-4: A novel indicator of pulmonary arterial hypertension severity and survival. Pulm Circ. 2023 Apr;13(2):e12235. PubMed PMID: 37152104

O'Callaghan B, Zablah JE, Weinman JP, Englund EK, Morgan GJ, Ivy DD, Frank BS, Mong DA, Malone LJ, Browne LP. Computed tomographic parenchymal lung findings in premature infants with pulmonary vein stenosis. Pediatr Radiol. 2023 Aug;53(9):1874-1884. PubMed PMID: 37106091

Beghetti M, Ivy D, Scott N, Machlitt-Northen S, Lukas MA. Letter to the Editor, regarding Li L, Zhu X, Chen X, Gao J, Ding C, et al. Advances in targeted therapy for pulmonary arterial hypertension in children. Eur J Pediatr. 2022 Dec 17. Eur J Pediatr. 2023 May;182(5):2453-2454. PubMed PMID: 36847876

Kheyfets VO, Sweatt AJ, Gomberg-Maitland M, Ivy DD, Condliffe R, Kiely DG, Lawrie A, Maron BA, Zamanian RT, Stenmark KR. Computational platform for doctor-artificial intelligence cooperation in pulmonary arterial hypertension prognostication: a pilot study. ERJ Open Res. 2023 Jan;9(1). PubMed PMID: 36776484

Shorofsky MJ, Morgan GJ, Mejia E, Rodriguez SA, Greene M, Sheaks P, Ivy D, Zablah JE. Management of Complex Pulmonary Vein Stenosis at Altitude Combining Comprehensive Percutaneous Interventional Treatment with Sirolimus, Pulmonary Hypertension Medications and Intraluminal Imaging with Optical Coherence Tomography. Pediatr Cardiol. 2023 Jun;44(5):1125-1134. PubMed PMID: 36723625

Ucrós S, Aparicio C, Castro-Rodriguez JA, Ivy D. High altitude pulmonary edema in children: A systematic review. Pediatr Pulmonol. 2023 Apr;58(4):1059-1067. PubMed PMID: 36562650

Maia PD, Gien J, Kinsella JP, Zablah J, Morgan G, Ivy DD, Abman SH, Frank BS. Hemodynamic Characterization of Neonates With Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension by Cardiac Catheterization. J Pediatr. 2023 Apr;255:230-235.e2. PubMed PMID: 36463937

Hopper RK, Abman SH, Elia EG, Avitabile CM, Yung D, Mullen MP, Austin ED, Bates A, Handler SS, Feinstein JA, Ivy DD, Kinsella JP, Mandl KD, Raj JU, Sleeper LA. Pulmonary Hypertension in Children with Down Syndrome: Results from the Pediatric Pulmonary Hypertension Network Registry. J Pediatr. 2023 Jan;252:131-140.e3. PubMed PMID: 36027975

McLennan D, Schäfer M, Barker AJ, Mitchell MB, Ing RJ, Browne LP, Ivy DD, Morgan GJ. Abnormal flow conduction through pulmonary arteries is associated with right ventricular volume and function in patients with repaired tetralogy of Fallot: does flow quality affect afterload?. Eur Radiol. 2023 Jan;33(1):302-311. PubMed PMID: 35852579

Collaco JM, Abman SH, Austin ED, Avitabile CM, Bates A, Fineman JR, Freire GA, Handler SS, Ivy DD, Krishnan US, Mullen MP, Varghese NP, Yung D, Nies MK, Everett AD, Zimmerman KO, Simmons W, Chakraborty H, Yenokyan G, Newell-Sturdivant A, Christensen E, Eyzaguirre LM, Hanley DF, Rosenzweig EB, Romer LH. Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension. Pulm Circ. 2023 Oct;13(4):e12305. PubMed PMID: 37915400

Schäfer M, Di Maria MV, Jaggers J, Stone ML, Campbell DN, Ivy DD, Mitchell MB. Hemi-Fontan and bidirectional Glenn operations result in flow-mediated viscous energy loss at the time of stage II palliation. JTCVS Open. 2023 Dec;16:836-843. PubMed PMID: 38204687

Ivy D, Rosenzweig EB, Abman SH, Beghetti M, Bonnet D, Douwes JM, Manes A, Berger RMF. Embracing the challenges of neonatal and paediatric pulmonary hypertension. Eur Respir J. 2024 Aug 29. [Epub ahead of print] PubMed PMID: 39209483

Griffiths M, Simpson CE, Yang J, Vaidya D, Nies MK, Brandal S, Damico R, Hassoun P, Ivy DD, Austin ED, Pauciulo MW, Lutz KA, Martin LJ, Rosenzweig EB, Benza RL, Nichols WC, Manlhiot C, Everett AD. Multiple Biomarkers Are Equivalent to Clinical Pulmonary Arterial Hypertension Survival Risk Models. Chest. 2024 Aug 16. [Epub ahead of print] PubMed PMID: 39154795

Frank BS, Gentzler ER, Avitabile CM, Miller-Reed K, Pan Z, Rosenzweig EB, Ivy DD, Krishnan US. Safety and Effectiveness of Selexipag in Pediatric Pulmonary Hypertension: A Retrospective Multicenter Cohort Study. J Pediatr. 2024 Aug 2;275:114221. [Epub ahead of print] PubMed PMID: 39097266

Ivy DD, Frank BS. Treat and Repair for Congenital Heart Disease and Pulmonary Hypertension: Not a Panacea. JACC Adv. 2024 Apr;3(4):100891. PubMed PMID: 38939683

Sun H, Stockbridge N, Ivy DD, Clark J, Bates A, Handler SS, Krishnan US, Mullen MP, Yung D, Hopper RK, Varghese NP, Avitabile CM, Fineman J, Austin ED, Freire G. Actigraphy Study Endpoints to Reduce Sample Size and Facilitate Drug Development for Pediatric Pulmonary Arterial Hypertension. J Pediatr. 2024 Nov 1;:114383. [Epub ahead of print] PubMed PMID: 39489285

Wacker J, Humpl T, Berger RMF, Ivy D, Bowers D, Bonnet D, Beghetti M. Application of a modified clinical classification for pulmonary arterial hypertension associated with congenital heart disease in children: emphasis on atrial septal defects and transposition of the great arteries. An analysis from the TOPP registry. Front Cardiovasc Med. 2024;11:1344014. PubMed PMID: 38370158

Ivy D, Beghetti M, Juaneda-Simian E, Ravindranath R, Lukas MA, Machlitt-Northen S, Scott N, Narita J, Berger RMF. Long-term safety and tolerability of ambrisentan treatment for pediatric patients with pulmonary arterial hypertension: An open-label extension study. Eur J Pediatr. 2024 May;183(5):2141-2153. PubMed PMID: 38366267

Neves da Silva HV, Weinman JP, Englund EK, Deterding RR, Ivy DD, Browne LP. Computed tomographic findings in TBX4 mutation: a common cause of severe pulmonary artery hypertension in children. Pediatr Radiol. 2024 Feb;54(2):199-207. PubMed PMID: 38191808

Cain MT, Schäfer M, Park S, Barker AJ, Vargas D, Stenmark KR, Yu YA, Bull TM, Ivy DD, Hoffman JRH. Characterization of pulmonary arterial stiffness using cardiac MRI. Int J Cardiovasc Imaging. 2024 Feb;40(2):425-439. PubMed PMID: 37902921

Ploegstra MJ, Ivy DD, Beghetti M, Bonnet D, Alehan D, Ablonczy L, Mattos S, Bowers D, Humpl T, Berger RMF. Long-term outcome of children with newly diagnosed pulmonary arterial hypertension: results from the global TOPP registry. Eur Heart J Qual Care Clin Outcomes. 2024 Jan 12;10(1):66-76. PubMed PMID: 36972621

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