Susan Boackle, MD

Recognitions

• Edmund L. Dubois, M.D. Memorial Lectureship, American College of Rheumatology (2010)
  
• Member, Western Society for Clinical Investigation (WSCI) (2009)
  
• Fellow, American College of Physicians (2008)
  
• Charley J. Smyth Endowed Chair for Rheumatology Research, University of Colorado School of Medicine (2008)

Research Interests

My research interests are primarily focused on investigating the cause of systemic lupus erythematosus, an autoimmune disease that can affect every organ system in the body. My research program has three parts: 1) the study of genes that contribute to the development of lupus in order to understand how they do this as this may lead to new treatments, 2) the study of markers in the blood and urine that may indicate how a person with lupus is responding to treatment or predict when they are going to have a flare so that their treatment can be optimized, and 3) the study of first-degree relatives (parents, siblings, children) of people with lupus to identify factors that lead to the development of lupus so that we can prevent it.

Publications

• Atisha-Fregoso Y, Malkiel S, Harris KM, Byron M, Ding L, Kanaparthi S, Barry WT, Gao W, Ryker K, Tosta P, Askanase AD, Boackle SA, Chatham WW, Kamen DL, Karp DR, Kirou KA, Sam Lim S, Marder B, McMahon M, Parikh SV, Pendergraft WF 3rd, Podoll AS, Saxena A, Wofsy D, Diamond B, Smilek DE, Aranow C, Dall'Era M. Phase II Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis. Arthritis Rheumatol. 2020 Aug 4. [Epub ahead of print] PubMed PMID: 32755035
• Boackle SA. Better Biomarkers for Lupus Disease Activity: Tools for Treating to Target. Arthritis Rheumatol. 2019 Mar;71(3):329-330. PubMed PMID: 30537205
• Patel Z, Lu X, Miller D, Forney CR, Lee J, Lynch A, Schroeder C, Parks L, Magnusen AF, Chen X, Pujato M, Maddox A, Zoller EE, Namjou B, Brunner HI, Henrickson M, Huggins JL, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath SK, Stevens AM, Freedman BI, Pons-Estel BA, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Martin J, Reveille JD, Anaya JM, James JA, Sivils KL, Criswell LA, Vilá LM, Petri M, Scofield RH, Kimberly RP, Edberg JC, Ramsey-Goldman R, Bang SY, Lee HS, Bae SC, Boackle SA, Cunninghame Graham D, Vyse TJ, Merrill JT, Niewold TB, Ainsworth HC, Silverman ED, Weisman MH, Wallace DJ, Raj P, Guthridge JM, Gaffney PM, Kelly JA, Alarcón-Riquelme ME, Langefeld CD, Wakeland EK, Kaufman KM, Weirauch MT, Harley JB, Kottyan LC. A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet. 2018 Apr 18. [Epub ahead of print] PubMed PMID: 29912393
• Boackle SA. Better Biomarkers for Lupus Disease Activity: Tools for Treating to Target. Arthritis Rheumatol. 2018 Dec 7. [Epub ahead of print] PubMed PMID: 30537205
• Boackle, S.A. 2018. The role of complement in SLE in Dubois Lupus Erythematosus and Related Syndromes, 9th Edition (Eds. D. Wallace and B. Hahn), Elsevier, Amsterdam, Netherlands 224-236.
• Boackle, S.A. 2017. CR2 in The Complement FactsBook, Second Edition (Eds. S. Barnum and T. Schein), Academic Press, Cambridge, Massachusetts, USA 2: 423-434.
• Berens-Norman HM, Boackle SA. Editorial: Subduing Lupus: Can Preclinical Autoimmune Disease Be Arrested?. Arthritis Rheumatol. 2016 Oct;68(10):2357-60. PubMed PMID: 27390125
• Deng Y, Zhao J, Sakurai D, Sestak AL, Osadchiy V, Langefeld CD, Kaufman KM, Kelly JA, James JA, Petri MA, Bae SC, Alarcón-Riquelme ME, Alarcón GS, Anaya JM, Criswell LA, Freedman BI, Kamen DL, Gilkeson GS, Jacob CO, Merrill JT, Gaffney PM, Sivils KM, Niewold TB, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Boackle SA, Vilá LM, Sohn II, Lee S, Chang DM, Song YW, Vyse TJ, Harley JB, Brown EE, Edberg JC, Kimberly RP, Cantor RM, Hahn BH, Grossman JM, Tsao BP. Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Ann Rheum Dis. 2016 Nov;75(11):2007-2013. PubMed PMID: 26783109
• Taylor RL, Cruickshank MN, Karimi M, Ng HL, Quail E, Kaufman KM, Harley JB, Abraham LJ, Tsao BP, Boackle SA, Ulgiati D. Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cells. Cell Mol Immunol. 2016 Jan;13(1):119-31. PubMed PMID: 25640655
• Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Ng HL, Abraham LJ, Wu H, Kelly JA, Glenn SB, Adler AJ, Williams AH, Comeau ME, Ziegler JT, Marion M, Alarcón-Riquelme ME, Alarcón GS, Anaya JM, Bae SC, Kim D, Lee HS, Criswell LA, Freedman BI, Gilkeson GS, Guthridge JM, Jacob CO, James JA, Kamen DL, Merrill JT, Sivils KM, Niewold TB, Petri MA, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Vilá LM, Vyse TJ, Kaufman KM, Harley JB, Langefeld CD, Gaffney PM, Brown EE, Edberg JC, Kimberly RP, Ulgiati D, Tsao BP, Boackle SA. Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis. 2016 Jan;75(1):242-52. PubMed PMID: 25180293
• Zhao J, Wu H, Langefeld CD, Kaufman KM, Kelly JA, Bae SC, Alarcón GS, Anaya JM, Criswell LA, Freedman BI, Kamen DL, Gilkeson GS, Jacob CO, James JA, Merrill JT, Gaffney PM, Sivils KM, Niewold TB, Petri MA, Song ST, Jeong HJ, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Boackle SA, Vilá LM, Chang DM, Song YW, Vyse TJ, Harley JB, Brown EE, Edberg JC, Kimberly RP, Hahn BH, Grossman JM, Tsao BP, La Cava A. Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clin Immunol. 2015 Dec;161(2):157-62. PubMed PMID: 26385092
• Lu X, Zoller EE, Weirauch MT, Wu Z, Namjou B, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath SK, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Reveille JD, Anaya JM, James JA, Sivils KL, Criswell LA, Vilá LM, Alarcón-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Joo YB, Choi J, Bae SC, Boackle SA, Graham DC, Vyse TJ, Guthridge JM, Gaffney PM, Langefeld CD, Kelly JA, Greis KD, Kaufman KM, Harley JB, Kottyan LC. Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression. Am J Hum Genet. 2015 May 7;96(5):731-9. PubMed PMID: 25865496
• Martins M, Williams AH, Comeau M, Marion M, Ziegler JT, Freedman BI, Merrill JT, Glenn SB, Kelly JA, Sivils KM, James JA, Guthridge JM, Alarcón-Riquelme ME, Bae SC, Kim JH, Kim D, Anaya JM, Boackle SA, Criswell LA, Kimberly RP, Alarcón GS, Brown EE, Vilá LM, Petri MA, Ramsey-Goldman R, Niewold TB, Tsao BP, Gilkeson GS, Kamen DL, Jacob CO, Stevens AM, Gaffney PM, Harley JB, Langefeld CD, Fesel C. Genetic association of CD247 (CD3?) with SLE in a large-scale multiethnic study. Genes Immun. 2015 Mar;16(2):142-50. PubMed PMID: 25569266
• Kottyan LC, Zoller EE, Bene J, Lu X, Kelly JA, Rupert AM, Lessard CJ, Vaughn SE, Marion M, Weirauch MT, Namjou B, Adler A, Rasmussen A, Glenn S, Montgomery CG, Hirschfield GM, Xie G, Coltescu C, Amos C, Li H, Ice JA, Nath SK, Mariette X, Bowman S, Rischmueller M, Lester S, Brun JG, Gøransson LG, Harboe E, Omdal R, Cunninghame-Graham DS, Vyse T, Miceli-Richard C, Brennan MT, Lessard JA, Wahren-Herlenius M, Kvarnström M, Illei GG, Witte T, Jonsson R, Eriksson P, Nordmark G, Ng WF, Anaya JM, Rhodus NL, Segal BM, Merrill JT, James JA, Guthridge JM, Scofield RH, Alarcon-Riquelme M, Bae SC, Boackle SA, Criswell LA, Gilkeson G, Kamen DL, Jacob CO, Kimberly R, Brown E, Edberg J, Alarcón GS, Reveille JD, Vilá LM, Petri M, Ramsey-Goldman R, Freedman BI, Niewold T, Stevens AM, Tsao BP, Ying J, Mayes MD, Gorlova OY, Wakeland W, Radstake T, Martin E, Martin J, Siminovitch K, Moser Sivils KL, Gaffney PM, Langefeld CD, Harley JB, Kaufman KM. The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet. 2015 Jan 15;24(2):582-96. PubMed PMID: 25205108
• Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens TW, Jacob CO, Alarcón-Riquelme ME, Sivils KL, Choi J, Joo YB, Bang SY, Lee HS, Bae SC, Shen N, Qian X, Tsao BP, Scofield RH, Harley JB, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. Am J Hum Genet. 2014 Apr 3;94(4):586-98. PubMed PMID: 24702955
• Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Ng HL, Abraham LJ, Wu H, Kelly JA, Glenn SB, Adler AJ, Williams AH, Comeau ME, Ziegler JT, Marion M, Alarcón-Riquelme ME, Alarcón GS, Anaya JM, Bae SC, Kim D, Lee HS, Criswell LA, Freedman BI, Gilkeson GS, Guthridge JM, Jacob CO, James JA, Kamen DL, Merrill JT, Sivils KM, Niewold TB, Petri MA, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Vilá LM, Vyse TJ, Kaufman KM, Harley JB, Langefeld CD, Gaffney PM, Brown EE, Edberg JC, Kimberly RP, Ulgiati D, Tsao BP, Boackle SA, for the BIOLUPUS and GENLES Networks. Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis. 2014 Sep 1. [Epub ahead of print] PubMed PMID: 25180293
• Vaughn SE, Foley C, Lu X, Patel ZH, Zoller EE, Magnusen AF, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath S, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Reveille JD, Anaya JM, James JA, Moser KL, Criswell LA, Vilá LM, Alarcón-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Binjoo Y, Choi J, Bae SC, Boackle SA, Vyse TJ, Guthridge JM, Namjou B, Gaffney PM, Langefeld CD, Kaufman KM, Kelly JA, Harley IT, Harley JB, Kottyan LC. Lupus risk variants in the PXK locus alter B-cell receptor internalization. Front Genet. 2014;5:450. PubMed PMID: 25620976
• Kaufman, K.M., Kelly, J.A., Hughes, T., Adler, A., Sánchez, E., Ojwang, J.O., Langefeld, C.D., Ziegler, J.T., Williams, A.H., Comeau, M.E., Marion, M.C., Glenn, S.B., James, J.A., Guthridge, J.M., Kimberly, R.P., Edberg, J.C., Ramsey-Goldman, R., Petri, M., Reveille, J.D., Brown, E.E., Vilá, L.M., Anaya, J.-M., Boackle, S.A., Stevens, A.M., Freedman, B.I., Criswell, L.A., Jacob, C.O., Scofield, R.H., Gilkeson, G.S., Moser, K.L., Gaffney, P.M., Merrill, J.T., Niewold, T.B., Vyse, T.J., Bae, S.-C., Alarcón-Riquelme, M.E. on behalf of the BIOLUPUS network, Harley, J.B., Sawalha, A.H., Tsao, B.P. 2013. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis 72: 437-444. PMCID: PMC3567234
• Deng, Y., Zhao, J., Sakurai, D., Kaufman, K.M., Edberg, J.C., Kimberly, R.P., Kamen, D.L., Gilkeson, G.S., Jacob, C.O., Scofield, R.H., Langefeld, C.D., Kelly, J.A., Ramsey-Goldman, R., Petri, M.A., Reveille, J.D., Vilá, L.M., Vyse, T.J., Freedman, B.I., Gaffney, P.M., Sivils, K.M., James, J.A., Gregersen, P.K., Anaya, J.-M., Niewold, T.B., Merrill, J.T., Criswell, L.A., Stevens, A.M., Boackle, S.A., Cantor, R.M., Chen, W., Hahn, B.H., Harley, J.B., Alarcón-Riquelme, M.E. on behalf of the BIOLUPUS and GENLES networks, Brown, E.E. on behalf of PROFILE, Tsao, B.P. 2013. MicroRNA-3148 modulates allelic expression of Toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet 9(2): e1003336. doi:10.1371/journal.pgen.1003336.
• Giles, B.M. and Boackle, S.A. 2013. Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus. Immunol Res 55:10-21.
• Sakurai D, Zhao J, Deng Y, Kelly JA, Brown EE, Harley JB, Bae SC, Alarc?n-Riquelme ME, BIOLUPUS and GENLES networks, Edberg JC, Kimberly RP, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Alarcón GS, Kaufman KM, Vyse TJ, Jacob CO, Gaffney PM, Sivils KM, James JA, Kamen DL, Gilkeson GS, Niewold TB, Merrill JT, Scofield RH, Criswell LA, Stevens AM, Boackle SA, Kim JH, Choi J, Pons-Estel BA, Argentine Collaborative Group, Freedman BI, Anaya JM, Martin J, Yu CY, Chang DM, Song YW, Langefeld CD, Chen W, Grossman JM, Cantor RM, Hahn BH, Tsao BP. Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. PLoS Genet. 2013;9(10):e1003870. PubMed PMID: 24130510
• Caster DJ, Korte EA, Nanda SK, McLeish KR, Oliver RK, G'sell RT, Sheehan RM, Freeman DW, Coventry SC, Kelly JA, Guthridge JM, James JA, Sivils KL, Alarcon-Riquelme ME, Scofield RH, Adrianto I, Gaffney PM, Stevens AM, Freedman BI, Langefeld CD, Tsao BP, Pons-Estel BA, Jacob CO, Kamen DL, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Kimberly RP, Martin J, Merrill JT, Harley JB, Kaufman KM, Reveille JD, Anaya JM, Criswell LA, Vila LM, Petri M, Ramsey-Goldman R, Bae SC, Boackle SA, Vyse TJ, Niewold TB, Cohen P, Powell DW. ABIN1 dysfunction as a genetic basis for lupus nephritis. J Am Soc Nephrol. 2013 Nov;24(11):1743-54. PubMed PMID: 23970121
• Namjou B, Kim-Howard X, Sun C, Adler A, Chung SA, Kaufman KM, Kelly JA, Glenn SB, Guthridge JM, Scofield RH, Kimberly RP, Brown EE, Alarcón GS, Edberg JC, Kim JH, Choi J, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Boackle SA, Freedman BI, Tsao BP, Langefeld CD, Vyse TJ, Jacob CO, Pons-Estel B, Argentine Collaborative Group, Niewold TB, Moser Sivils KL, Merrill JT, Anaya JM, Gilkeson GS, Gaffney PM, Bae SC, Alarcón-Riquelme ME, BIOLUPUS and GENLES Networks, Harley JB, Criswell LA, James JA, Nath SK. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PLoS One. 2013;8(8):e69404. PubMed PMID: 23950893
• Boackle SA. Advances in lupus genetics. Curr Opin Rheumatol. 2013 Sep;25(5):561-8. PubMed PMID: 23917156
• Manku H, Langefeld CD, Guerra SG, Malik TH, Alarcon-Riquelme M, Anaya JM, Bae SC, Boackle SA, Brown EE, Criswell LA, Freedman BI, Gaffney PM, Gregersen PA, Guthridge JM, Han SH, Harley JB, Jacob CO, James JA, Kamen DL, Kaufman KM, Kelly JA, Martin J, Merrill JT, Moser KL, Niewold TB, Park SY, Pons-Estel BA, Sawalha AH, Scofield RH, Shen N, Stevens AM, Sun C, Gilkeson GS, Edberg JC, Kimberly RP, Nath SK, Tsao BP, Vyse TJ. Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. PLoS Genet. 2013;9(7):e1003554. PubMed PMID: 23874208
• Ramos PS, Oates JC, Kamen DL, Williams AH, Gaffney PM, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Jacob CO, Tsao BP, Alarcón GS, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, James JA, Guthridge JM, Merrill JT, Boackle SA, Freedman BI, Scofield RH, Stevens AM, Vyse TJ, Criswell LA, Moser KL, Alarcón-Riquelme ME, Langefeld CD, Harley JB, Gilkeson GS. Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry. J Rheumatol. 2013 Jun;40(6):842-9. PubMed PMID: 23637325
• Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Alarcón GS, Vyse TJ, Pons-Estel BA, Argentine Collaborative Group, Freedman BI, Gaffney PM, Sivils KM, James JA, Gregersen PK, Anaya JM, Niewold TB, Merrill JT, Criswell LA, Stevens AM, Boackle SA, Cantor RM, Chen W, Grossman JM, Hahn BH, Harley JB, Alarc?n-Riquelme ME, BIOLUPUS and GENLES networks, Brown EE, Tsao BP. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet. 2013;9(2):e1003336. PubMed PMID: 23468661
• Giles BM, Boackle SA. Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus. Immunol Res. 2013 Mar;55(1-3):10-21. PubMed PMID: 22941560
• Kaufman KM, Zhao J, Kelly JA, Hughes T, Adler A, Sanchez E, Ojwang JO, Langefeld CD, Ziegler JT, Williams AH, Comeau ME, Marion MC, Glenn SB, Cantor RM, Grossman JM, Hahn BH, Song YW, Yu CY, James JA, Guthridge JM, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Anaya JM, Boackle SA, Stevens AM, Freedman BI, Criswell LA, Pons Estel BA, Argentine Collaborative Group, Lee JH, Lee JS, Chang DM, Scofield RH, Gilkeson GS, Merrill JT, Niewold TB, Vyse TJ, Bae SC, Alarcón-Riquelme ME, BIOLUPUS network, Jacob CO, Moser Sivils K, Gaffney PM, Harley JB, Sawalha AH, Tsao BP. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis. 2013 Mar;72(3):437-44. PubMed PMID: 22904263
• Hughes, T., Adler, A., Kelly, J.A., Kaufman, K.M., Williams, A., Langefeld, C.D., Brown, E.E., Alarcón, G.S., Kimberly, R.P., Edberg, J.C., Ramsey-Goldman, R., Petri, M., Boackle, S.A., Stevens, A.M., Reveille, J.D., Sanchez, E., Martin, J., Niewold, T.B., Vilá, L.M., Scofield, R.H., Gilkeson, G.S., Gaffney, P.M., Criswell, L.A., Moser, K.L., Merrill, J.T., Jacob, C.O., Tsao, B.P., James, J.A., Vyse, T.J., Alarcón-Riquelme, M.E. on behalf of the BIOLUPUS network, Harley, J.B., Richardson, B.C., Sawalha, A.H. 2012. Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis Rheum 64: 485-492.
• Lin, C.P., Adrianto, I., Lessard, C.J., Kelly, J.A., Kaufman, K.M., Guthridge, J.M., Freedman, B.I., Anaya, J.-M., Alarcón-Riquelme, M.E. on behalf of the BIOLUPUS and GENLES networks, Pons-Estel, B.A., Martin, J., Glenn, S., Adler, A., Bae, S.-C., Park, S.-Y., Bang, S.-Y., Song, Y.-W., Boackle, S.A., Brown, E.E., Edberg, J.C., Alarcón, G.S., Petri, M.A., Criswell, L.A., Ramsey-Goldman, R., Reveille, J.D., Vilá, L.M., Gilkeson, G.S., Kamen, D.L., Ziegler, J., Jacob, C.O., Rasmussen, A., James, J.A., Kimberly, R.P., Merrill, J.T., Niewold, T.B., Scofield, R.H., Stevens, A.M., Tsao, B.P., Vyse, T.J., Langefeld, C.D., Moser, K.L., Harley, J.B., Gaffney, P.M., Montgomery, C.G. 2012. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes Immun (in press).
• Hughes, T., Adler, A., Merrill, J.T., Kelly, J.A., Kaufman, K.M., Williams, A., Langefeld, C.D., Gilkeson, G.S., Sanchez, E., Martin, J., Boackle, S.A., Stevens, A.M., Alarcón, G.S., Niewold, T.B., Brown, E.E., Kimberly, R.P., Edberg, J.C., Ramsey-Goldman, R., Petri, M., Reveille, J.D., Criswell, L.A. Vilá, L.M., Jacob, C.O., Gaffney, P.M., Moser, K.L., Vyse, T.J., Alarcón-Riquelme, M.E. on behalf of the BIOLUPUS network, James, J.A., Tsao, B.P., Scofield, R.H., Harley, J.B., Richardson, B.C., Sawalha, A.H. 2012. Analysis of autosomal genes reveals gene–sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis (in press).
• Namjou, B. Choi, C.-B., Harley, I.T.W., Alarcón-Riquelme, M.E. on behalf of BIOLUPUS, Kelly, J.A., Glenn, S.B., Ojwang, J.O., Adler, A., Kim, K., Gallant, C.J., Boackle, S.A., Criswell, L.A., Kimberly, R.P., Brown, E.E., Edberg, J., Alarcón, G.S., Stevens, A.M., Jacob, C.O., Gilkeson, G.S., Kamen, D.L., Tsao, B.P., Anaya, J.-M., Kim, E.-M., Park, S.-Y., Sung, Y.-K., Guthridge, J.M., Merrill, J.T., Petri, M., Ramsey-Goldman, R., Vilá, L.M., Niewold, T.B., Martin, J., Pons-Estel, B.A., on behalf of GENLES, Vyse, T.J., Freedman, B.I., Moser, K.L., Gaffney, P.M., Williams, A.H., Comeau, M.E., Reveille, J.D., Kang, C., James, J.A., Scofield, R.H., Langefeld, C.D., Kaufman, K.M., Harley, J.B., Bae, S.-C. 2012. Evaluation of TRAF6 in a large multi-ancestral lupus cohort. Arthritis Rheum (in press).
• Kim, K., Brown, E.E., Choi, C.-B., Alarcón-Riquelme, M.E., on behalf of BIOLUPUS, Kelly, J.A., Glenn, S.B., Ojwang, J.O., Adler, A., Bang, S.-Y., Lee, H.-S., Boackle, S.A., Criswell, L.A., Kim, T., Alarcón, G.S., Edberg, J.C., Stevens, A.M., Jacob, C.O., Gilkeson, G.S., Kamen, D.L., Tsao, B.P., Anaya, J.-M., Guthridge, J.M., Nath, S.K., Richardson, B., Sawalha, A.H., Kang, Y.M., Shim, S.C., Suh, C.-H., Lee, S.-K., Kim, C.-S., Merrill, J.T., Petri, M., Ramsey-Goldman, R., Vilá, L.M., Niewold, T.B., Martin, J., Pons-Estel, B.A., on behalf of GENLES, Vyse, T.J., Freedman, B.I., Moser, K.L., Gaffney, P.M., Williams, A., Comeau, M., Reveille, J.D., James, J.A., Scofield, R.H., Langefeld, C.D., Kaufman, K.M., Harley, J.B., Kang, C., Kimberly, R.P., Bae, S.-C. 2012. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestry populations. Ann Rheum Dis (in press).
• Lessard, C.J., Adrianto, I., Ice, J.A., Wiley, G.B., Kelly, J.A., Glenn, S.B., Adler, A.J., Li, H., Rasmussen, A., Williams, A.H., Ramos, P.S., Grundahl, K.M., Gallant, C.J., Alarcón-Riquelme, M.E. on behalf of the BIOLUPUS and GENLES network, Alarcón, G.S., Anaya, J.-M., Bae, S.-C., Boackle, S.A., Brown, E.E., Chang, D.-M., Criswell, L.A., Edberg, J.C., Freedman, B.I., Gilkeson, G.S., Jacob, C.O., James, J.A., Kamen, D.L., Kimberly, R.P., Martin, J., Merrill, J.T., Niewold, T.B., Park, S.-Y., Petri, M.A., Pons-Estel, B.A., Ramsey-Goldman, R., Reveille, J.D., Scofield, R.H., Song, Y.W., Stevens, A.M., Tsao, B.P., Vilá, L., Vyse, T.,J., Yu, C.-Y., Guthridge, J.M., Kaufman, K.M., Harley, J.B., Wakeland, E.K., Langefeld, C.D., Gaffney, P.M., Montgomery, C.G., Moser, K.L. 2012. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale, multi-racial replication study. Am J Human Gen (in press).
• Cruickshank, M.N., Karimi, M., Mason, R.L., Fenwick, E., Mercer, T., Tsao, B.P. Boackle, S.A., and Ulgiati, D. 2012. Transcriptional effects of a lupus-associated polymorphism in the 5’ untranslated region (UTR) of human complement receptor 2 (CR2/CD21). Mol Immunol 52: 165-173.
• Thurman, J.M., Tchepeleva, S.N., Haas, M., Panzer, S., Boackle, S.A., Glogowska, M., Quigg, R., Holers, V.M. 2012. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J Physiol Renal Physiol 302: F1529-F1536.
• Wang, S. Adrianto, I., Wiley, G.B., Lessard, C.J., Kelly, J.A., Adler, A.J., Glenn, S.B., Williams, A.H., Ziegler, J.T., Comeau, M.E., Marion, M.C., Wakeland, B.E., Liang, C., Kaufman, K.M., Guthridge, J.M., Alarcón-Riquelme, M.E., on behalf of the BIOLUPUS and GENLES Networks, Alarcón, G.S.,, Anaya, J.-M., Bae, S.-C., Kim, J.-H., Joo, Y.B., Boackle, S.A., Brown, E.E., Petri, M.A., Ramsey-Goldman, R., Reveille, J.D., Vilá, L.M., Criswell, L.A., Edberg, J.C., Freedman, B.I., Gilkeson, G.S., Jacob, C.O., James, J.A., Kamen, D.L., Kimberly, R.P., Martin, J., Merrill, J.T., Niewold, T.B., Pons-Estel, B.A., Scofield, R.H., Stevens, A.M., Tsao, B.P., Vyse, T.J., Langefeld, C.D., Harley, J.B., Wakeland, E.K., Moser, K.L., Montgomery, C.G., Gaffney, P.M. 2012. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes Immun 13: 380-387.
• Adrianto, I., Wang, S., Wiley, G.B., Lessard, C.J., Kelly, J.A., Adler, A.J., Glenn, S.B., Williams, A.H., Ziegler, J.T., Comeau, M.E., Marion, M.C., Wakeland, B.E., Liang, C., Kaufman, K.M., Guthridge, J.M., Alarcón-Riquelme, M.E., on behalf of the BIOLUPUS and GENLES Networks, Alarcón, G.S., Anaya, J.M., Bae, S.C., Kim, J.H., Joo, Y.B., Boackle, S.A., Brown, E.E., Petri, M.A., Ramsey-Goldman, R., Reveille, J.D., Vilá, L.M., Criswell, L.A., Edberg, J.C., Freedman, B.I., Gilkeson, G.S., Jacob, C.O., James, J.A., Kamen, D.L., Kimberly, R.P., Martin, J., Merrill, J.T., Niewold, T.B., Pons-Estel, B.A., Scofield, R.H., Stevens, A.M., Tsao, B.P., Vyse, T.J., Langefeld, C.D., Harley, J.B., Wakeland, E.K., Moser, K.L., Montgomery, C.G., and Gaffney, P.M. 2012. Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus. Arthritis Rheum 64: 3695-3705. PMCID: PMC3485412
• Sánchez, E., Rasmussen, A., RIba, L., Acevedo, E., Kelly, J.A., Langefeld, C.D., Williams, A.H., Ziegler, J.T., Comeau, M.E., Marion, M.C., Garcia-De La Torre, I., Maradiaga-Ceceña, M.A., Cardiel, M.H., Esquivel-Valerio, J.A., Rodriguez-Amado, J., Moctezuma, J.F., Miranda, P., Perandones, C., Castel, C., Laborde, H.A., Alba, P., Musuruana, J., Goecke, A., Foster, C., Anaya, J.-M., Kaufman, K.M., Adler, A., Glenn, S.B., Brown, E.E., Alarcón, G.S., Kimberly, R.P., Edberg, J.C., Vilá, L., Criswell, L.A., Gilkeson, G.S., Niewold, T.B., Martin, J., Vyse, T.J., Boackle, S.A., Ramsey-Goldman, R., Stevens, A.M., Scofield, R.H., Petri, M., Merrill, J.T., Reveille, J.D., Tsao, B.P., Orozco, L., Baca, V., Moser, K.L., Gaffney, P.M., James, J.A., Harley, J.B., Tusié-Luna, T., Pons-Estel, B.A., Jacob, C.O., Alarcón-Riquelme, M.E. 2012. Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in Amerindian-European populations. Arthritis Rheum 64:3687-3694.
• Namjou, B., Kothari, P.H., Kelly, J., Glenn, S., Ojwang, J.O., Adler, A., Alarcón-Riquelme, M.E., Boackle, S.A., Criswell, L., Kimberly, R., Stevens, A.M., Jacob, C., Tsao, B.P., Gilkeson, G.S., Kamen, D.L., Merrill, J.T., Niewold, T., Vyse, T.J., Bae, S.-C., Scofield, R.H., Moser, K., Gaffney, P., James, J.A., Langefeld, C.D., Kaufman, K.M., Harley, J.B., Atkinson, J.P. 2011. Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort. Genes Immun (in press).
• Adrianto, I., Wen, F., Templeton, A., Wiley, G., King, J.B., Lessard, C.J., Bates, J.S., Hu, Y., Kelly, J.A., Kaufman, K.M., Guthridge, J.M., Alarcón-Riquelme, M.E. on behalf of the BIOLUPUS and GENLES Networks, Anaya, J.-M., Bae, S.-C., Bang, S.-Y., Boackle, S.A., Brown, E.E., Petri, M.A., Gallant, C., Ramsey-Goldman, R., Reveille, J.D., Vila, L.M., Criswell, L.A., Edberg, J.C., Freedman, B.I., Gregersen, P.K., Gilkeson, G.S., Jacob, C.O., James, J.A., Kamen, D.L., Kimberly, R.P., Martin, J., Merrill, J.T., Niewold, T.B., Park, S.-Y., Pons-Estel, B.A., Scofield, R.H., Stevens, A.M., Tsao, B.P., Vyse, T.J., Langefeld, C.D., Harley, J.B., Moser, K.L., Webb, C.F., Humphrey, M.B., Montgomery, C.G., Gaffney, P.M. 2011. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet (in press).
• Zhao, J., Wu, H., Khosravi, M., Cui, H., Qian, X., Kelly, J.A., Kaufman, K.M., Langefeld, C.D., Williams, A.H., Comeau, M.E., Ziegler, J.T., Marion, M.C., Adler, A., Glenn, S.B., Alarcón-Riquelme, M.E. on behalf of the BIOLUPUS and GENLES networks, Harley, J.B., Bae, S.-C., Lee, J.H., Lee, J.-S., Jacob, C.O., Vyse, T.J., Niewold, T.B., Gaffney, P.M., Moser, K.L., Kimberly, R.P., Edberg, J.C., Brown, E.E., Petri, M.A., Ramsey-Goldman, R., Vilá, L.M., Reveille, J.D., James, J.A., Gilkeson, G.S., Kamen, D.L., Freedman, B.I., Anaya, J.-M., Merrill, J.T., Criswell, L.A., Scofield, R.H., Stevens, A.M., Boackle, S.A., Guthridge, J.M., Chang, D.-M., Song, Y.W., Grossman, J.M., Hahn, B.H., Goodship, T.H.J., Cantor, R.M., Yu, C.-Y., Shen, N., Tsao, B.P. 2011. Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet 7(5): e1002079. doi:10.1371/journal.pgen.1002079.
• Tan, W., Sunahori, K., Zhao, J., Deng, Y., Kaufman, K.M., Kelly, J.A., Bae, S.-C., Lee, J.H., Lee, J.-S., Chang, D.-M., Song, Y.W., Yu, C.-Y., Kimberly, R.P., Edberg, J.C., Brown, E.E., Petri, M.A., Ramsey-Goldman, R., Vilá, L.M., Reveille, J.D., Alarcón-Riquelme, M.E. on behalf of the BIOLUPUS and GENLES networks, Harley, J.B., Boackle, S.A., Stevens, A.M., Scofield, R.H., Merrill, J.T., Freedman, B.I., Anaya, J.-M., Criswell, L.A., Jacob, C.O., Vyse, T.J., Niewold, T.B., Gaffney, P.M., Moser, K.L., Gilkeson, G.S., Kamen, D.L., James, J.A., Grossman, J.M., Hahn, B.H., Tsokos, G.C., Tsao, B.P. 2011. Association of PPP2CA polymorphisms with SLE susceptibility in multiple ethnic groups. Arthritis Rheum 63: 2755-2763.
• Kenyon, K.D., Cole, C., Thurman, J.M., Crawford, F., Kappler, J.W., Bratton, D.L., Boackle, S.A., Henson, P.M. 2011. IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol 187: 2101-2111.
• Lessard, C.J., Adrianto, I., Kelly, J.A., Kaufman, K.M., Grundahl, K.M., Adler, A., Williams, A.H., Gallant, C., Alarcón-Riquelme, M.E. for the BIOLUPUS and GENLES Networks, Anaya, J.-M., Bae, S.-C., Boackle, S.A., Brown, E.E., Chang, D.-M., Criswell, L.A., Edberg, J.C., Freedman, B.I., Gregersen, P.K., Gilkeson, G.S., Jacob, C.O., James, J.A., Kamen, D.L., Kimberly, R.P., Martin, J., Merrill, J.T., Niewold, T.B., Park, S.-Y., Petri, M.A., Pons-Estel, B.A., Ramsey-Goldman, R., Reveille, J.D., Song, Y.W., Stevens, A.M., Tsao, B.P., Vila, L.M., Vyse, T.J., Yu, C.-Y., Guthridge, J.M., Bruner, G.R., Langefeld, C.D., Montgomery, C., Harley, J.B., Scofield, R.H., Gaffney, P.M., Moser, K.L. 2010. Identification of a novel systemic lupus erythematosus susceptibility locus as 11p13 between PDHX and CD44 in a multi-ethnic study. Am J Human Gen 88: 83-91.
• Tchepeleva, S.N., Thurman, J.M., Ruff, K., Perkins, S.J., Morel, L., Boackle, S.A. An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation. J Immunol (submitted).
• Lough, K.M., Douglas, K.B., Homme, C.L., Ulgiati, D., Tsao, B.P., Boackle, S.A. Identification of specific single-nucleotide polymorphisms that modify alternative splicing in a lupus-associated haplotype of complement receptor 2. 97th American Association of Immunologists Annual Meeting, Baltimore, Maryland.
• Tchepeleva, S.N., Thurman, J.M., Ruff, K., Perkins, S.J., Morel, L., Boackle, S.A. 2010. An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation. J Immunol 185: 2331-2339. NIHMS257729
• Douglas, K.B. Douglas, Windels, D.C., Zhao, J., Gadeliya, A.V., Wu, H., Kaufman, K.M., Harley, J.B., Merrill, J., Kimberly, R.P., Alarcón, G.S., Brown, E.E. Edberg, J.C., Ramsey-Goldman,R., Petri, M., Reveille, J.D., Vilá, L.M., Gaffney, P.M., James, J.A., Moser, K.L., Alarcón-Riquelme, M.E., Vyse, T.J., Gilkeson, G.S., Jacob, C.O., Ziegler, J.T., Langefeld, C.D., Ulgiati, D., Tsao, B.P., Boackle, S.A. 2009. Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing. Genes Immun (submitted, returned for revisions).
• Wu, H.*, Boackle, S.A.*, Hanvivadhanakul, P.*, Ulgiati, D.*, Grossman, J.M., Lee, Y., Shen, N., Abraham, L.J., Mercer, T.R., Park, E., Hebert, L.A., Rovin, B.H., Birmingham, D.J., Chang, D.-M., Chen, C.J., McCurdy, D., Badsha, H.M., Thong, B.Y.H., Chng, H.H., Arnett, F.C., Wallace, D.J., Yu, C.Y., Hahn, B.H., Cantor, R.M., Tsao, B.P. 2007. Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus. Proc Natl Acad Sci 104: 3961-3966. (*These authors contributed equally to this work.)
• Giles, B.M., Tchepeleva, S.N, Kachinski, J.J., Ruff, K., Croker, B.P., Morel, L., and Boackle, S.A. 2007. Augmentation of NZB autoimmune phenotypes by the NZW-derived Sle1c lupus susceptibility interval. J Immunol (in press)
• Kulik, L., Marchbank, K.J., Lyubchenko, T., Kuhn, K.A., Liubchenko, G.A., Haluszczak, C., Gibson, M.G., Boackle, S.A., and Holers, V.M. 2007. Intrinsic B cell hypo—responsiveness in mice prematurely expressing human CR2/CD21 during B cell development. Eur J Immunol (in press)
• Tchepeleva, S.N., Thurman, J.M., Kraus, D.M., Perkins, S.J., Morel, L., and Boackle, S.A. 2007. The structurally altered Sle1c allele of Crry has enhanced complement regulatory function. Mol Immunol 44: 249.
• Taraseviciene-Stewart, L., Nicolls, M.R., Kraskauskas, D., Scerbavicius, R., Burns, N., Cool, C., Wood, K., Parr, J.E., Boackle, S., and Voelkel, N.F. 2007. Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling. Am J Respir Crit Care Med 175: 1280-1289.
• Tchepeleva, S.N., Kraus, D.M., Thurman, J.M., Morel, L., Boackle, S.A. 2005. Enhanced function of the complement regulatory protein Crry as a novel mechanism for autoantibody production in murine systemic lupus erythematosus. Arthritis Rheum 52: S458.
• Li, S., Boackle. S.A., Holers, V.M., Lambris, J.D., and Blatteis, C.M. 2005. Complement component C5a is integral to the febrile response of mice to lipopolysaccharide. Neuroimmunomodulation 12: 67-80.
• Chen, Y., Perry, D., Boackle, S.A., Sobel, E.S., Molina, H., Croker, B.P., and Laurence Morel. 2005. Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c. J Immunol 175: 1080-1089.
• Giles, B.M., Tchepeleva, S.N, Kachinski, J.J., Croker, B.P., Morel, L., and Boackle, S.A. Augmentation of NZB autoimmune phenotypes by the NZW-derived Sle1c lupus susceptibility interval. (submitted, returned for revisions)
• Wu, H.*, Boackle, S.A.*, Hanvivadhanakul, P.*, Ulgiati, D.*, Grossman, J.M., Lee, Y., Shen, N., Abraham, L.J., Park, E., Hebert, L.A., Rovin, B.H., Birmingham, D.J., Chang, D.-M., Chen, C.J., McCurdy, D., Badsha, H.M., Thong, B.Y.H., Chng, H.H., Arnett, F.C., Wallace, D.J., Yu, C.Y., Hahn, B.H., Cantor, R.M., Tsao, B.P. Association of a functional single-nucleotide polymorphism in human complement receptor 2 with systemic lupus erythematosus. (in preparation, will be submitted in April 2006)
• Boackle, S.A. 2017. The role of complement in SLE in Dubois Lupus Erythematosus and Related Syndromes, 9th Edition (Eds. D. Wallace and B. Hahn), Elsevier, Amsterdam, Netherlands (in press).

Professional Memberships

• American College of Physicians (ACP), Fellow
• American College of Rheumatology (ACR), Fellow
• American Medical Association (AMA), Member
• American Association of Immunologists (AAI), Member
• American Association for the Advancement of Science (AAAS), Member
• International Complement Society (ICS), Member

Practice Locations

UCHealth Rheumatology Clinic - Anschutz Medical Campus
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-7700

Hospital Affiliation

• University of Colorado Hospital
• Veterans Affairs Medical Center

Center Affiliations

• Colorado Clinical & Translational Sciences Institute (CCTSI)

Specialty Information

Specialties

• Rheumatology, Board Certification (1996, 2014)

Conditions & Treatments

• Bones, Joints and Muscles - Arthritis
• Immune System - Autoimmune Disorders
• Immune System
• Immune System - Rheumatoid Arthritis
• Bones, Joints and Muscles