David Wagner, PhD
Associate Professor, Medicine-Pulmonary Sciences & Critical Care

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Graduate School :
  • PhD, East Tennessee State University (1995)
Undergraduate School:
  • BS, King College (TN) (1984)
Department: Medicine-Pulmonary Sciences & Critical Care

Professional Titles

  • Associate Professor
  • Chief Scientific Officer
  • Head, Immunology Section

Recognition & Awards

  • Philip R. Lee Award in Diabetes Research, American Diabetes Association (2010)
    This award is given to the highest scoring Career Development Award Grant administered by the ADA. A typical year has over 400 applicants.


  • Faculty Advisor, PhD program (2015)
    School of Medicine, Immunology and Microbiology
    Im interested in autoimmune regulation; defining pathogenic T cell subsets and controlling those. Specific disease areas include: Type 1 Diabetes, Multiple Sclerosis; Cardio-Vascular Disease/Atherosclerosis and Stroke.


  • Not available yet "Understanding Inflammation During Type 1 Diabetes"
  • Frontiers in Neurology "Ocrelizumab Anti-CD20 Treatment Regulates TH40 Cells, A Biomarker of Systemic Inflammation, In All Disease Courses of Multiple Sclerosis" ON TIME Christian Curran, Gisela Vaitaitis, Dan Waid, Enrique Alverez, Enrique Alverez and David H Wagner
  • Curran C, Vaitaitis G, Waid D, Volmer T, Alverez E, Wagner DH. Ocrevus reduces TH40 cells, a biomarker of systemic inflammation, in relapsing multiple sclerosis (RMS) and in progressive multiple sclerosis (PMS). J Neuroimmunol. 2022 Dec 7;374:578008. [Epub ahead of print] PubMed PMID: 36535240
  • Lu Y, Xu M, Dorrier CE, Zhang R, Mayer CT, Wagner D, McGavern DB, Hodes RJ. CD40 Drives Central Nervous System Autoimmune Disease by Inducing Complementary Effector Programs via B Cells and Dendritic Cells. J Immunol. 2022 Dec 1;209(11):2083-2092. PubMed PMID: 36426970
  • Vaitaitis GM, Olmstead MH, Waid DM, Carter JR, Wagner DH Jr. CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor. Reply to Pagni PP, Wolf A, Lo Conte M et al [letter]. Diabetologia. 2019 Sep;62(9):1730-1731. PubMed PMID: 31286154
  • Vaitaitis GM, Rihanek M, Alkanani AK, Waid DM, Gottlieb PA, Wagner DH. Biomarker discovery in pre-Type 1 Diabetes; Th40 cells as a predictive risk factor. J Clin Endocrinol Metab. 2019 May 7. [Epub ahead of print] PubMed PMID: 31063181
  • Vaitaitis GM, Yussman MG, Wagner DH Jr. A CD40 targeting peptide prevents severe symptoms in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2019 Jul 15;332:8-15. PubMed PMID: 30925295
  • Vaitaitis GM, Yussman MG, Waid DM, Wagner DH Jr. Th40 cells (CD4 CD40 Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells. PLoS One. 2017 Feb 13;12(2):e0172037. PubMed PMID: 28192476
  • Vaitaitis GM, Waid DM, Yussman MG, Wagner DH Jr. CD40-mediated signalling influences trafficking, T-cell receptor expression, and T-cell pathogenesis, in the NOD model of type 1 diabetes. Immunology. 2017 Oct;152(2):243-254. PubMed PMID: 28542921
  • Vaitaitis GM, Yussman MG, Waid DM, Wagner DH Jr. Th40 cells (CD4 CD40 Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells. PLoS One. 2017;12(2):e0172037. PubMed PMID: 28192476
  • Wagner DH Jr. Overlooked Mechanisms in Type 1 Diabetes Etiology: How Unique Costimulatory Molecules Contribute to Diabetogenesis. Front Endocrinol (Lausanne). 2017;8:208. PubMed PMID: 28878738
  • Wagner DH. Of the multiple mechanisms leading to type 1 diabetes, T cell receptor revision may play a prominent role (is type 1 diabetes more than a single disease?). Clin Exp Immunol. 2016 Sep;185(3):271-80. PubMed PMID: 27271348
  • Deng G, Carter J, Traystman RJ, Wagner DH, Herson PS. Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation. J Neuroimmunol. 2014 Sep 15;274(1-2):132-40. PubMed PMID: 25084739
  • Waid DM, Schreiner T, Vaitaitis G, Carter JR, Corboy JR, Wagner DH Jr. Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells. J Neuroimmunol. 2014 May 15;270(1-2):75-85. PubMed PMID: 24690203
  • Vaitaitis GM, Olmstead MH, Waid DM, Carter JR, Wagner DH Jr. A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice. Diabetologia. 2014 Nov;57(11):2366-73. PubMed PMID: 25104468
  • Vaitaitis GM, Wagner DH Jr. CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression. Cell Mol Immunol. 2013 Nov;10(6):483-9. PubMed PMID: 24037181
  • Vaitaitis GM, Carter JR, Waid DM, Olmstead MH, Wagner DH Jr. An alternative role for Foxp3 as an effector T cell regulator controlled through CD40. J Immunol. 2013 Jul 15;191(2):717-25. PubMed PMID: 23776180
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Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045

Specialty Information

  • Pulmonary Disease
Personal Interests
I am passionate about Mountain Biking and Road Biking in addition to fitness. I am a very good cook.

Volunteer Activities
American Diabetes Association Community Leadership Board

Public Speaking
I give regular talks on type 1 diabetes research areas. Also I am under consideration for TED talks X.

General Information

Graduate Schools:
  • PhD, East Tennessee State University (1995)
Undergraduate Schools:
  • BS, King College (TN) (1984)
Download CV
Department: Medicine-Pulmonary Sciences & Critical Care
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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