Chris Silliman, MD, PhD

Professional Titles

• Professor
• Senior Independent Investigator
• Head Clinical Competency Committee
• Associate Director HOB Fellowship

Research Interests

Publications

• Coleman JR, Moore EE, Kelher MR, Jones K, Cohen MJ, Banerjee A, Silliman CC. Losing the forest for the trees: the complexities of fibrinolysis will never be explained with one variable alone. J Trauma Acute Care Surg. 2023 Oct 3. [Epub ahead of print] PubMed PMID: 37784230
• Thielen O, Mitra S, Debot M, Schaid T, Hallas W, Gallagher LT, Erickson C, Cralley A, Stafford P, Silliman C, D'Alessandro A, Hansen K, Sauaia A, Moore E, Mosnier L, Griffin J, Cohen M. Mitigation of Trauma Induced Endotheliopathy by Activated Protein C: A Potential Therapeutic for Post-Injury Thromboinflammation. J Trauma Acute Care Surg. 2023 Sep 21. [Epub ahead of print] PubMed PMID: 37733304
• Schaid TR Jr, LaCroix I, Cohen MJ, Hansen KC, Moore EE, Sauaia A, Cralley AL, Thielen O, Hallas W, Erickson C, Mitra S, Dzieciatkowska M, Silliman CC, D'Alessandro A. Metabolomic and Proteomic Changes in Trauma-induced Hypocalcemia. Shock. 2023 Sep 5. [Epub ahead of print] PubMed PMID: 37695733
• Cohen MJ, Erickson CB, Lacroix IS, Debot M, Dzieciatkowska M, Schaid TR, Hallas MW, Thielen ON, Cralley AL, Banerjee A, Moore EE, Silliman CC, D'Alessandro A, Hansen KC. Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients. bioRxiv. 2023 Sep 9. PubMed PMID: 37645811
• Cralley AL, Erickson C, Schaid TR Jr, Hallas W, Thielen O, Mitra S, Stafford P, Hom P, Silliman C, Cohen MJ, Moore EE, D'Alessandro A, Hansen KC. The proteomic and metabolomic signatures of isolated and polytrauma traumatic brain injury. Am J Surg. 2023 Jul 28. [Epub ahead of print] PubMed PMID: 37541795
• LaCroix IS, Cohen M, Moore EE, Dzieciatkowska M, Silliman CC, Hansen KC, D'Alessandro A. Omics markers of platelet transfusion in trauma patients. Transfusion. 2023 Aug;63(8):1447-1462. PubMed PMID: 37466356
• Coleman JR, D'Alessandro A, LaCroix I, Dzieciatkowska M, Lutz P, Mitra S, Gamboni F, Ruf W, Silliman CC, Cohen MJ. A METABOLOMIC AND PROTEOMIC ANALYSIS OF PATHOLOGIC HYPERCOAGULABILITY IN TRAUMATIC BRAIN INJURY PATIENTS AFTER DURA VIOLATION. J Trauma Acute Care Surg. 2023 Jul 5. [Epub ahead of print] PubMed PMID: 37405823
• LaCroix IS, Cralley A, Moore EE, Cendali FI, Dzieciatkowska M, Hom P, Mitra S, Cohen M, Silliman C, Sauaia A, Hansen KC, D'Alessandro A. Omics Signatures of Tissue Injury and Hemorrhagic Shock in Swine. Ann Surg. 2023 Jun 19. [Epub ahead of print] PubMed PMID: 37334680
• Eitel A, Moore EE, Kelher MR, Cohen MJ, Kissau D, Hadley JB, Debot M, Banerjee A, Silliman CC. Bradykinin release following trauma and hemorrhagic shock causes pulmonary alveolar leak in a rodent model. J Trauma Acute Care Surg. 2023 Oct 1;95(4):558-564. PubMed PMID: 37314576
• Esparza O, Hernandez G, Rojas-Sanchez G, Calzada-Martinez J, Nemkov T, Kelher M, Kelly K, Silliman CC, DomBourian M, Dumont LJ, D'Alessandro A, Davizon-Castillo P. Platelets from blood diversion pouches (DPs) are a suitable alternative for functional, bioenergetic, and metabolomic analyses. Blood Transfus. 2023 Mar 31. [Epub ahead of print] PubMed PMID: 37235734
• Eitel AP, Moore EE, Sauaia A, Kelher MR, Vigneshwar NG, Bartley MG, Hadley JB, Burlew CC, Campion EM, Fox CJ, Lawless RA, Pieracci FM, Platnick KB, Moore HB, Cohen MJ, Silliman CC. A proposed clinical coagulation score for research in trauma-induced coagulopathy. J Trauma Acute Care Surg. 2023 Jun 1;94(6):798-802. PubMed PMID: 36805626
• Cralley AL, Moore EE, Dubose J, Brenner ML, Schaid TR, DeBot M, Cohen M, Silliman C, Fox C, Sauaia A. OUTCOMES FOLLOWING ZONE 3 AND ZONE 1 AORTIC OCCLUSION FOR THE TREATMENT OF BLUNT PELVIC INJURIES. Shock. 2023 May 1;59(5):685-690. PubMed PMID: 36802216
• Coleman JR, Moore EE, Kelher MR, Jones K, Cohen MJ, Banerjee A, Silliman CC. Elucidating the molecular mechanisms of fibrinolytic shutdown after severe injury: The role of thrombin-activatable fibrinolysis inhibitor. J Trauma Acute Care Surg. 2023 Jun 1;94(6):857-862. PubMed PMID: 36787438
• Cralley AL, Moore EE, Sauaia A, Carani PH, Schaid TR Jr, DeBot M, Fragoso M, Ghasabyan A, Hansen K, Cohen MJ, Silliman CC, Fox CJ. REBOA for the Treatment of Blast Polytrauma: Zone 3 Provides Cerebral Perfusion, Attenuates Organ Dysfunction and Reperfusion Coagulopathy Compared to Zone 1 in a Swine Model. J Trauma Acute Care Surg. 2023 May 1;94(5):718-724. PubMed PMID: 36749658
• Schaid TR Jr, LaCroix I, Hansen KC, D'Alessandro A, Moore EE, Sauaia A, Dzieciatkowska M, DeBot M, Cralley AL, Thielen O, Hallas W, Erickson C, Mitra S, Banerjee A, Jones K, Silliman CC, Cohen MJ. A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player. J Trauma Acute Care Surg. 2023 Mar 1;94(3):361-370. PubMed PMID: 36730076
• DeBot M, Erickson C, Kelher M, Schaid TR Jr, Moore EE, Sauaia A, Cralley A, LaCroix I, D'Alessandro A, Hansen K, Cohen MJ, Silliman CC, Coleman J. Platelet and cryoprecipitate transfusions from female donors improve coagulopathy in vitro. J Trauma Acute Care Surg. 2023 Apr 1;94(4):497-503. PubMed PMID: 36728345
• Coleman JR, Moore EE, Schmitt L, Hansen K, Dow N, Freeman K, Cohen MJ, Silliman CC. Estradiol provokes hypercoagulability and affects fibrin biology: A mechanistic exploration of sex dimorphisms in coagulation. J Trauma Acute Care Surg. 2023 Feb 1;94(2):179-186. PubMed PMID: 36694329
• Schaid TR Jr, Cohen MJ, D'Alessandro A, Silliman CC, Moore EE, Sauaia A, Dzieciatkowska M, Hallas W, Thielen O, DeBot M, Cralley A, LaCroix I, Erickson C, Mitra S, Banerjee A, Jones K, Hansen KC. TRAUMA INDUCES INTRAVASCULAR HEMOLYSIS, EXACERBATED BY RED BLOOD CELL TRANSFUSION AND ASSOCIATED WITH DISRUPTED ARGININE-NITRIC OXIDE METABOLISM. Shock. 2023 Jan 1;59(1):12-19. PubMed PMID: 36378232
• Cralley AL, Moore EE, Coleman JR, Vigneshwar N, Bartley M, Kissau D, Eitel A, Hom P, Mitra S, Ghasabyan A, Fragoso M, Guo Z, Deguchi H, Griffin JH, Cohen MJ, Silliman CC, Banerjee A, Hansen K, Sauaia A. Hemorrhagic shock and tissue injury provoke distinct components of trauma-induced coagulopathy in a swine model. Eur J Trauma Emerg Surg. 2023 Apr;49(2):1079-1089. PubMed PMID: 36319860
• Coleman JR, Fabbri S, Anderson M, Moore EE, Cohen MJ, Hadley J, Ghasabyan A, Chandler J, Kelher M, Freeman K, Miller ZD, Silliman CC. Beyond uterine atony: characterizing postpartum hemorrhage coagulopathy. Am J Obstet Gynecol MFM. 2023 Mar;5(3):100822. PubMed PMID: 36464240
• LaCroix IS, Cohen M, Moore EE, Dzieciatkowska M, Nemkov T, Schaid TR Jr, Debot M, Jones K, Silliman CC, Hansen KC, D'Alessandro A. Omics Markers of Red Blood Cell Transfusion in Trauma. Int J Mol Sci. 2022 Nov 10;23(22). PubMed PMID: 36430297
• Hadley JB, Kelher MR, D'Alessandro A, Gamboni F, Hansen K, Coleman J, Jones K, Cohen M, Moore EE, Banerjee A, Silliman CC. A pilot study of the metabolic profiles of apheresis platelets modified by donor age and sex and in vitro short-term incubation with sex hormones. Transfusion. 2022 Dec;62(12):2596-2608. PubMed PMID: 36309927
• Hadley JB, Kelher MR, Coleman JR, Kelly KK, Dumont LJ, Esparza O, Banerjee A, Cohen MJ, Jones K, Silliman CC. Hormones, age, and sex affect platelet responsiveness in vitro. Transfusion. 2022 Sep;62(9):1882-1893. PubMed PMID: 35929193
• Cralley AL, Moore EE, Fox CJ, Kissau D, DeBot M, Schaid TR, Mitra S, Hom P, Fragoso M, Ghasabyan A, Erickson C, D'Alessandro A, Hansen KC, Cohen MJ, Silliman CC, Sauaia A. Zone 1 REBOA in a combat DCBI swine model does not worsen brain injury. Surgery. 2022 Aug;172(2):751-758. PubMed PMID: 35690490
• Jones WL, Ramos CR, Banerjee A, Moore EE, Hansen KC, Coleman JR, Kelher M, Neeves KB, Silliman CC, Di Paola J, Branchford B. Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength. Platelets. 2022 Nov 17;33(8):1119-1131. PubMed PMID: 35659185
• Schaid TR Jr, Hansen KC, Sauaia A, Moore EE, DeBot M, Cralley AL, Erickson C, Silliman CC, Banerjee A, Ghasabyan A, Jones K, Lacroix I, Mitra S, D'Alessandro A, Cohen MJ. Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation. J Trauma Acute Care Surg. 2022 Nov 1;93(5):588-596. PubMed PMID: 35610738
• Hadley JB, Kelher MR, Coleman JR, Kelly KK, Dumont LJ, Esparza O, Banerjee A, Cohen MJ, Jones K, Silliman CC. Hormones, age, and sex affect platelet responsiveness in vitro. Transfusion. 2022 Sep;62(9):1882-1893. PubMed PMID: 35929193
• Cralley AL, Moore EE, Fox CJ, Kissau D, DeBot M, Schaid TR, Mitra S, Hom P, Fragoso M, Ghasabyan A, Erickson C, D'Alessandro A, Hansen KC, Cohen MJ, Silliman CC, Sauaia A. Zone 1 REBOA in a combat DCBI swine model does not worsen brain injury. Surgery. 2022 Aug;172(2):751-758. PubMed PMID: 35690490
• Jones WL, Ramos CR, Banerjee A, Moore EE, Hansen KC, Coleman JR, Kelher M, Neeves KB, Silliman CC, Di Paola J, Branchford B. Apolipoprotein A-I, elevated in trauma patients, inhibits platelet activation and decreases clot strength. Platelets. 2022 Nov 17;33(8):1119-1131. PubMed PMID: 35659185
• Schaid TR Jr, Hansen KC, Sauaia A, Moore EE, DeBot M, Cralley AL, Erickson C, Silliman CC, Banerjee A, Ghasabyan A, Jones K, Lacroix I, Mitra S, D'Alessandro A, Cohen MJ. Post-injury Complement C4 Activation is Associated with Adverse Outcomes and is Potentially Influenced by Plasma Resuscitation. J Trauma Acute Care Surg. 2022 May 25. [Epub ahead of print] PubMed PMID: 35610738
• Cralley AL, Moore EE, Kissau D, Coleman JR, Vigneshwar N, DeBot M, Schaid TR Jr, Moore HB, Cohen MJ, Hansen K, Silliman CC, Sauaia A, Fox CJ. A combat casualty relevant dismounted complex blast injury model in swine. J Trauma Acute Care Surg. 2022 Aug 1;93(2S Suppl 1):S110-S118. PubMed PMID: 35545808
• Morton AP, Hadley JB, Ghasabyan A, Kelher MR, Moore EE, Bevers S, Dzieciatkowska M, Hansen KC, Cohen MS, Banerjee A, Silliman CC. The a-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro. J Trauma Acute Care Surg. 2022 Jan 1;92(1):159-166. PubMed PMID: 34538821
• DeBot M, Mitra S, Lutz P, Schaid TR Jr, Stafford P, Hadley JB, Hom P, Sauaia A, Silliman CC, Moore EE, Cohen MJ. SHOCK INDUCES ENDOTHELIAL PERMEABILITY AFTER TRAUMA THROUGH INCREASED ACTIVATION OF RHOA GTPASE. Shock. 2022 Dec 1;58(6):542-548. PubMed PMID: 36548645
• DeBot M, Eitel AP, Moore EE, Sauaia A, Lutz P, Schaid TR Jr, Hadley JB, Kissau DJ, Cohen MJ, Kelher MR, Silliman CC. BLOOD TYPE O IS A RISK FACTOR FOR HYPERFIBRINOLYSIS AND MASSIVE TRANSFUSION AFTER SEVERE INJURY. Shock. 2022 Dec 1;58(6):492-497. PubMed PMID: 36548640
• Morton AP, Hadley JB, Ghasabyan A, Kelher MR, Moore EE, Bevers S, Dzieciatkowska M, Hansen KC, Cohen MS, Banerjee A, Silliman CC. The a-globin Chain of Hemoglobin Potentiates Tissue Plasminogen Activator Induced Hyperfibrinolysis in vitro. J Trauma Acute Care Surg. 2021 Sep 16. [Epub ahead of print] PubMed PMID: 34538821
• Coleman JR, Moore EE, Samuels JM, Cohen MJ, Silliman CC, Ghasabyan A, Chandler J, Butenas S. Whole Blood Thrombin Generation in Severely Injured Patients Requiring Massive Transfusion. J Am Coll Surg. 2021 May;232(5):709-716. PubMed PMID: 33548446
• Welsby IJ, Norris PJ, Mauermann WJ, Podgoreanu MV, Conn CM, Meade L, Cannon T, Keating SM, Silliman CC, Kehler M, Schulte PJ, Kor DJ. Bedside Allogeneic Erythrocyte Washing with a Cell Saver to Remove Cytokines, Chemokines, and Cell-derived Microvesicles. Anesthesiology. 2021 Mar 1;134(3):395-404. PubMed PMID: 33503656
• Stettler GR, Moore EE, Nunns GR, Kelher M, Banerjee A, Silliman CC. Effects of Blood Components and Whole Blood in a Model of Severe Trauma-Induced Coagulopathy. J Surg Res. 2021 Mar;259:55-61. PubMed PMID: 33278796
• Stettler GR, Moore EE, Huebner BR, Nunns GR, Moore HB, Coleman JR, Kelher M, Banerjee A, Silliman CC. 28-day thawed plasma maintains a(2) -antiplasmin levels and inhibits tPA-induced fibrinolysis. Vox Sang. 2021 Feb;116(2):181-189. PubMed PMID: 32894784
• Nunns GR, Vigneshwar N, Kelher MR, Stettler GR, Gera L, Reisz JA, D'Alessandro A, Ryon J, Hansen KC, Gamboni F, Moore EE, Peltz ED, Cohen MJ, Jones KL, Sauaia A, Liang X, Banerjee A, Ghasabyan A, Chandler JG, Rodawig S, Jones C, Eitel A, Hom P, Silliman CC. Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-Mediated ARDS. Ann Surg. 2020 Nov 18. [Epub ahead of print] PubMed PMID: 33214479
• Coleman JR, Moore EE, Silliman CC, Stettler GR, Nunns GR, Samuels JM, Bartley MG, Vigneshwar NG, Cohen MJ, Fragoso M, Sauaia A. Examining the Effect of Hypertonic Saline Administered for Reduction of Intracranial Hypertension on Coagulation. J Am Coll Surg. 2020 Mar;230(3):322-330.e2. PubMed PMID: 31843691
• Coleman JR, Moore EE, Sauaia A, Samuels JM, Moore HB, Ghasabyan A, Chandler JG, Swope ML, Fleming CD, Banerjee A, Cohen MJ, Silliman CC, Peltz ED, Chapman MP. Untangling Sex Dimorphisms in Coagulation: Initial Steps Toward Precision Medicine for Trauma Resuscitation. Ann Surg. 2020 Jun;271(6):e128-e130. PubMed PMID: 31850983
• Stettler GR, Moore EE, Nunns GR, Moore HB, Huebner BR, Silliman CC, Banerjee A, Sauaia A. Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients. Eur J Trauma Emerg Surg. 2020 Mar 10. [Epub ahead of print] PubMed PMID: 32157340
• Coleman JR, Moore EE, Moore HB, Chapman MP, Cohen MJ, Silliman CC, Sauaia A. Tranexamic acid disturbs the dynamics of postinjury fibrinolysis. ANZ J Surg. 2020 Apr;90(4):420-422. PubMed PMID: 32339428
• Stettler GR, Moore EE, Huebner BR, Nunns GR, Moore HB, Coleman JR, Kelher M, Banerjee A, Silliman CC. 28-day thawed plasma maintains a(2) -antiplasmin levels and inhibits tPA-induced fibrinolysis. Vox Sang. 2020 Sep 7. [Epub ahead of print] PubMed PMID: 32894784
• Samuels JM, Coleman JR, Moore EE, Bartley M, Vigneshwar N, Cohen M, Silliman CC, Sauaia A, Banerjee A. Alternative Complement Pathway Activation Provokes a Hypercoagulable State with Diminished Fibrinolysis. Shock. 2020 May;53(5):560-565. PubMed PMID: 31441792
• Coleman JR, Moore EE, Samuels JM, Ryon JJ, Nelson JT, Olson A, Caus S, Bartley MG, Vigneshwar NG, Cohen MJ, Banerjee A, Silliman CC, Butenas S. Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury. Surgery. 2019 Dec;166(6):1122-1127. PubMed PMID: 31522748
• Coleman JR, Moore EE, Zilberman-Rudenko J, Samuels JM, Cohen MJ, Silliman CC, Banerjee A, Sauaia A, Griffin JH, Deguchi H. Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects. Shock. 2019 Nov;52(5):554-555. PubMed PMID: 31613865
• Coleman JR, Moore EE, Kelher MR, Samuels JM, Cohen MJ, Sauaia A, Banerjee A, Silliman CC, Peltz ED. Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy. J Trauma Acute Care Surg. 2019 Nov;87(5):1052-1060. PubMed PMID: 31162329
• Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S. An update of the transfusion-related acute lung injury (TRALI) definition. Transfus Clin Biol. 2019 Nov;26(4):354-356. PubMed PMID: 31221537
• Samuels JM, Moore EE, Coleman JR, Sumislawski JJ, Cohen MJ, Silliman CC, Banerjee A, Ghasabyan A, Chandler J, Sauaia A. Obesity is associated with postinjury hypercoagulability. J Trauma Acute Care Surg. 2019 Oct;87(4):876-882. PubMed PMID: 31233444
• Kuldanek SA, Kelher M, Silliman CC. Risk factors, management and prevention of transfusion-related acute lung injury: a comprehensive update. Expert Rev Hematol. 2019 Sep;12(9):773-785. PubMed PMID: 31282773
• Coleman JR, Moore EE, Samuels JM, Ryon JJ, Nelson JT, Olson A, Caus S, Bartley MG, Vigneshwar NG, Cohen MJ, Banerjee A, Silliman CC, Butenas S. Whole blood thrombin generation is distinct from plasma thrombin generation in healthy volunteers and after severe injury. Surgery. 2019 Sep 12. [Epub ahead of print] PubMed PMID: 31522748
• Samuels JM, Coleman JR, Moore EE, Bartley M, Vigneshwar N, Cohen M, Silliman CC, Sauaia A, Banerjee A. Alternative Complement Pathway Activation Provokes A Hypercoagulable State with Diminished Fibrinolysis. Shock. 2019 Aug 21. [Epub ahead of print] PubMed PMID: 31441792
• Coleman JR, Moore EE, Zilberman-Rudenko J, Samuels JM, Cohen MJ, Silliman CC, Banerjee A, Sauaia A, Griffin JH, Deguchi H. Rapid Communication: Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects. Shock. 2019 Jul 30. [Epub ahead of print] PubMed PMID: 31365491
• Kuldanek SA, Kelher M, Silliman CC. Risk factors, management and prevention of transfusion-related acute lung injury: a comprehensive update. Expert Rev Hematol. 2019 Sep;12(9):773-785. PubMed PMID: 31282773
• Samuels JM, Moore EE, Coleman JR, Sumislawski JJ, Cohen MJ, Silliman CC, Banerjee A, Ghasabyan A, Chandler J, Sauaia A. Obesity is associated with postinjury hypercoagulability. J Trauma Acute Care Surg. 2019 Oct;87(4):876-882. PubMed PMID: 31233444
• Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S. An update of the transfusion-related acute lung injury (TRALI) definition. Transfus Clin Biol. 2019 Jun 12. [Epub ahead of print] PubMed PMID: 31221537
• Coleman JR, Moore EE, Kelher MR, Samuels JM, Cohen MJ, Sauaia A, Banerjee A, Silliman CC, Peltz E. Female Platelets Have Distinct Functional Activity Compared to Male Platelets: Implications in Transfusion Practice and Treatment of Trauma-Induced Coagulopathy. J Trauma Acute Care Surg. 2019 May 31. [Epub ahead of print] PubMed PMID: 31162329
• Stettler GR, Moore EE, Moore HB, Nunns GR, Coleman JR, Colvis A, Ghasabyan A, Cohen MJ, Silliman CC, Banerjee A, Sauaia A. Variability in international normalized ratio and activated partial thromboplastin time after injury are not explained by coagulation factor deficits. J Trauma Acute Care Surg. 2019 Sep;87(3):582-589. PubMed PMID: 31136528
• Stettler GR, Moore EE, Moore HB, Nunns GR, Coleman JR, Colvis A, Ghasabyan A, Cohen MJ, Silliman CC, Banerjee A, Sauaia A. Variability in international normalized ratio and activated partial thromboplastin time after injury are not explained by coagulation factor deficits. J Trauma Acute Care Surg. 2019 Sep;87(3):582-589. PubMed PMID: 31136528
• Sumislawski JJ, Christie SA, Kornblith LZ, Stettler GR, Nunns GR, Moore HB, Moore EE, Silliman CC, Sauaia A, Callcut RA, Cohen MJ. Discrepancies between conventional and viscoelastic assays in identifying trauma-induced coagulopathy. Am J Surg. 2019 Jun;217(6):1037-1041. PubMed PMID: 31029284
• Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S. A consensus redefinition of transfusion-related acute lung injury. Transfusion. 2019 Jul;59(7):2465-2476. PubMed PMID: 30993745
• Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'Alessandro A, Moore HB. Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements. Blood Transfus. 2019 Sep;17(5):347-356. PubMed PMID: 30747701
• Coleman JR, Moore EE, Samuels JM, Cohen MJ, Sauaia A, Sumislawski JJ, Ghasabyan A, Chandler JG, Banerjee A, Silliman CC, Peltz ED. Trauma Resuscitation Consideration: Sex Matters. J Am Coll Surg. 2019 May;228(5):760-768.e1. PubMed PMID: 30677527
• Samuels JM, Moore EE, Silliman CC, Banerjee A, Cohen MJ, Ghasabyan A, Chandler J, Coleman JR, Sauaia A. Severe traumatic brain injury is associated with a unique coagulopathy phenotype. J Trauma Acute Care Surg. 2019 Apr;86(4):686-693. PubMed PMID: 30601456
• Stettler GR, Moore EE, Moore HB, Nunns GR, Silliman CC, Banerjee A, Sauaia A. Redefining postinjury fibrinolysis phenotypes using two viscoelastic assays. J Trauma Acute Care Surg. 2019 Apr;86(4):679-685. PubMed PMID: 30562328
• Stettler GR, Sumislawski JJ, Moore EE, Nunns GR, Kornblith LZ, Conroy AS, Callcut RA, Silliman CC, Banerjee A, Cohen MJ, Sauaia A. Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion. J Trauma Acute Care Surg. 2018 Oct;85(4):734-740. PubMed PMID: 30059456
• Loi MM, Kelher M, Dzieciatkowska M, Hansen KC, Banerjee A, West FB, Stanley C, Briel M, Silliman CC. A comparison of different methods of red blood cell leukoreduction and additive solutions on the accumulation of neutrophil-priming activity during storage. Transfusion. 2018 Aug;58(8):2003-2012. PubMed PMID: 30171813
• Stettler GR, Sumislawski JJ, Moore EE, Nunns GR, Kornblith LZ, Conroy AS, Callcut RA, Silliman CC, Banerjee A, Cohen MJ, Sauaia A. Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion. J Trauma Acute Care Surg. 2018 Oct;85(4):734-740. PubMed PMID: 30059456
• Moore HB, Moore EE, Chapman MP, McVaney K, Bryskiewicz G, Blechar R, Chin T, Burlew CC, Pieracci F, West FB, Fleming CD, Ghasabyan A, Chandler J, Silliman CC, Banerjee A, Sauaia A. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial. Lancet. 2018 Jul 28;392(10144):283-291. PubMed PMID: 30032977
• Nunns GR, Stringham JR, Gamboni F, Moore EE, Fragoso M, Stettler GR, Silliman CC, Banerjee A. Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue. J Surg Res. 2018 Sep;229:262-270. PubMed PMID: 29936999
• Stettler GR, Moore EE, Nunns GR, Chandler J, Peltz E, Silliman CC, Banerjee A, Sauaia A. Rotational thromboelastometry thresholds for patients at risk for massive transfusion. J Surg Res. 2018 Aug;228:154-159. PubMed PMID: 29907206
• Coleman JR, Moore EE, Chapman MP, Banerjee A, Silliman CC, Ghasabyan A, Chandler J, Samuels JM, Sauaia A. Rapid TEG efficiently guides hemostatic resuscitation in trauma patients. Surgery. 2018 Sep;164(3):489-493. PubMed PMID: 29903508
• Nunns GR, Moore EE, Stettler GR, Moore HB, Ghasabyan A, Cohen M, Huebner BR, Silliman CC, Banerjee A, Sauaia A. Empiric transfusion strategies during life-threatening hemorrhage. Surgery. 2018 Aug;164(2):306-311. PubMed PMID: 29709368
• Kuldanek S, Silliman CC. Mortality after red blood cell transfusions from previously pregnant donors: complexities in the interpretation of large data. J Thorac Dis. 2018 Feb;10(2):648-652. PubMed PMID: 29608196
• Huebner BR, Moore EE, Moore HB, Gonzalez E, Kelher MR, Sauaia A, Banerjee A, Silliman CC. Thrombin stimulates increased plasminogen activator inhibitor-1 release from liver compared to lung endothelium. J Surg Res. 2018 May;225:1-5. PubMed PMID: 29605018
• Banerjee A, Silliman CC, Moore EE, Dzieciatkowska M, Kelher M, Sauaia A, Jones K, Chapman MP, Gonzalez E, Moore HB, D'Alessandro A, Peltz E, Huebner BE, Einerson P, Chandler J, Ghasabayan A, Hansen K. Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma. J Trauma Acute Care Surg. 2018 Jun;84(6):929-938. PubMed PMID: 29554044
• Weisberg SP, Shaz BH, Tumer G, Silliman CC, Kelher MR, Cohn CS. PAS-C platelets contain less plasma protein, lower anti-A and anti-B titers, and decreased HLA antibody specificities compared to plasma platelets. Transfusion. 2018 Apr;58(4):891-895. PubMed PMID: 29473178
• Reisz JA, Wither MJ, Moore EE, Slaughter AL, Moore HB, Ghasabyan A, Chandler J, Schaub LJ, Fragoso M, Nunns G, Silliman CC, Hansen KC, Banerjee A, Sheppard FR, D'Alessandro A. All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients. J Trauma Acute Care Surg. 2018 Mar;84(3):537-541. PubMed PMID: 29112093
• Slaughter AL, Nunns GR, D'Alessandro A, Banerjee A, Hansen KC, Moore EE, Silliman CC, Nemkov T, Moore HB, Fragoso M, Leasia K, Peltz ED. The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model. Shock. 2018 May;49(5):580-590. PubMed PMID: 28727610
• McKinney C, Kelher MR, Nuss R, Cool A, Hoffman A, Silliman CC: Microparticles from Children with Sickle Cell Anemia and the Acute Chest Syndrome Cause Activation of Human Pulmonary Endothelium. Journal of Blood Disorders, Symptoms & Treatments 2(1) 009, www.scientonline, 2018.
• Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC. LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol. 2017 Jan;101(1):261-273. PubMed PMID: 27531930
• Moore HB, Moore EE, Huebner BR, Stettler GR, Nunns GR, Einersen PM, Silliman CC, Sauaia A. Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis. J Surg Res. 2017 Dec;220:438-443. PubMed PMID: 28755903
• Huebner BR, Moore EE, Moore HB, Shepherd-Singh R, Sauaia A, Stettler GR, Nunns GR, Silliman CC. 14-Day thawed plasma retains clot enhancing properties and inhibits tPA-induced fibrinolysis. J Surg Res. 2017 Nov;219:145-150. PubMed PMID: 29078874
• Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. Discussion of: "The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen". Am J Surg. 2017 Dec;214(6):1219. PubMed PMID: 29021098
• Stettler GR, Moore EE, Moore HB, Nunns GR, Huebner BR, Einersen P, Ghasabyan A, Silliman CC, Banerjee A, Sauaia A. Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion. Surgery. 2017 Dec;162(6):1286-1294. PubMed PMID: 28964508
• Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen. Am J Surg. 2017 Dec;214(6):1215-1218. PubMed PMID: 28951066
• Silliman CC, Kelher MR, Khan SY, West FB, McLaughlin NJD, Elzi DJ, England K, Bjornsen J, Kuldanek SA, Banerjee A. Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation. Transfusion. 2017 Nov;57(11):2690-2700. PubMed PMID: 28880373
• Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin. J Trauma Acute Care Surg. 2017 Dec;83(6):1053-1061. PubMed PMID: 28837538
• Reisz JA, Slaughter AL, Culp-Hill R, Moore EE, Silliman CC, Fragoso M, Peltz ED, Hansen KC, Banerjee A, D'Alessandro A. Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats. Blood Adv. 2017 Jul 25;1(17):1296-1305. PubMed PMID: 29296771
• Huebner BR, Moore EE, Moore HB, Stettler GR, Nunns GR, Lawson P, Sauaia A, Kelher M, Banerjee A, Silliman CC. Thrombin Provokes Degranulation of Platelet a-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1). Shock. 2017 Dec 26. [Epub ahead of print] PubMed PMID: 29280928
• Mitra S, Schiller D, Anderson C, Gamboni F, D'Alessandro A, Kelher M, Silliman CC, Banerjee A, Jones KL. Hypertonic saline attenuates the cytokine-induced pro-inflammatory signature in primary human lung epithelia. PLoS One. 2017;12(12):e0189536. PubMed PMID: 29253007
• Moore HB, Moore EE, Huebner BR, Dzieciatkowska M, Stettler GR, Nunns GR, Lawson PJ, Ghasabyan A, Chandler J, Banerjee A, Silliman C, Sauaia A, Hansen KC. Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator. J Trauma Acute Care Surg. 2017 Dec;83(6):1014-1022. PubMed PMID: 29190254
• Lawson PJ, Moore HB, Moore EE, Stettler GR, Pshak TJ, Kam I, Silliman CC, Nydam TL. Preoperative thrombelastography maximum amplitude predicts massive transfusion in liver transplantation. J Surg Res. 2017 Dec;220:171-175. PubMed PMID: 29180179
• Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen. Am J Surg. 2017 Oct 5. [Epub ahead of print] PubMed PMID: 29021098
• Stettler GR, Moore EE, Moore HB, Nunns GR, Huebner BR, Einersen P, Ghasabyan A, Silliman CC, Banerjee A, Sauaia A. Platelet adenosine diphosphate receptor inhibition provides no advantage in predicting need for platelet transfusion or massive transfusion. Surgery. 2017 Sep 27. [Epub ahead of print] PubMed PMID: 28964508
• Nunns GR, Moore EE, Chapman MP, Moore HB, Stettler GR, Peltz E, Burlew CC, Silliman CC, Banerjee A, Sauaia A. The hypercoagulability paradox of chronic kidney disease: The role of fibrinogen. Am J Surg. 2017 Sep 18. [Epub ahead of print] PubMed PMID: 28951066
• Silliman CC, Kelher MR, Khan SY, West FB, McLaughlin NJD, Elzi DJ, England K, Bjornsen J, Kuldanek SA, Banerjee A. Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation. Transfusion. 2017 Sep 6. [Epub ahead of print] PubMed PMID: 28880373
• Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human Neutrophil Elastase Mediates Fibrinolysis Shutdown Through Competitive Degradation of Plasminogen and Generation of Angiostatin. J Trauma Acute Care Surg. 2017 Aug 23. [Epub ahead of print] PubMed PMID: 28837538
• Warner MA, Welsby IJ, Norris PJ, Silliman CC, Armour S, Wittwer ED, Santrach PJ, Meade LA, Liedl LM, Nieuwenkamp CM, Douthit B, van Buskirk CM, Schulte PJ, Carter RE, Kor DJ. Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery. BMJ Open. 2017 Aug 18;7(8):e016398. PubMed PMID: 28821525
• Moore HB, Moore EE, Huebner BR, Stettler GR, Nunns GR, Einersen PM, Silliman CC, Sauaia A. Tranexamic acid is associated with increased mortality in patients with physiological fibrinolysis. J Surg Res. 2017 May 8. [Epub ahead of print] PubMed PMID: 28755903
• Slaughter AL, Nunns GR, D'Alessandro A, Banerjee A, Hansen KC, Moore EE, Silliman CC, Nemkov T, Moore HB, Fragoso M, Leasia K, Peltz ED. The Metabolopathy of Tissue Injury, Hemorrhagic Shock and Resuscitation in a Rat Model. Shock. 2017 Jul 19. [Epub ahead of print] PubMed PMID: 28727610
• D'Alessandro A, Moore HB, Moore EE, Reisz JA, Wither MJ, Ghasasbyan A, Chandler J, Silliman CC, Hansen KC, Banerjee A. Plasma succinate is a predictor of mortality in critically injured patients. J Trauma Acute Care Surg. 2017 Sep;83(3):491-495. PubMed PMID: 28590356
• Stettler GR, Moore EE, Moore HB, Lawson PJ, Fragoso M, Nunns GR, Silliman CC, Banerjee A. Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy. J Surg Res. 2017 Sep;217:207-212. PubMed PMID: 28583756
• Moore HB, Moore EE, Chapman MP, Huebner BR, Einersen PM, Oushy S, Silliman CC, Banerjee A, Sauaia A. Viscoelastic Tissue Plasminogen Activator Challenge Predicts Massive Transfusion in 15 Minutes. J Am Coll Surg. 2017 Jul;225(1):138-147. PubMed PMID: 28522144
• Huebner BR, Moore EE, Moore HB, Sauaia A, Stettler G, Dzieciatkowska M, Hansen K, Banerjee A, Silliman CC. Freeze-dried plasma enhances clot formation and inhibits fibrinolysis in the presence of tissue plasminogen activator similar to pooled liquid plasma. Transfusion. 2017 Aug;57(8):2007-2015. PubMed PMID: 28500652
• Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Hansen K, Banerjee A, Moore HB, D'Alessandro A. Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine. J Trauma Acute Care Surg. 2017 Oct;83(4):635-642. PubMed PMID: 28463938
• Yoshida T, Blair A, D'alessandro A, Nemkov T, Dioguardi M, Silliman CC, Dunham A. Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage. Blood Transfus. 2017 Mar;15(2):172-181. PubMed PMID: 28263176
• Silliman CC, Burke T, Kelher MR. The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration. Blood Transfus. 2017 Mar;15(2):131-136. PubMed PMID: 28263170
• Einersen PM, Moore EE, Chapman MP, Moore HB, Gonzalez E, Silliman CC, Banerjee A, Sauaia A. Rapid thrombelastography thresholds for goal-directed resuscitation of patients at risk for massive transfusion. J Trauma Acute Care Surg. 2017 Jan;82(1):114-119. PubMed PMID: 27805995
• Kelher MR, Banerjee A, Gamboni F, Anderson C, Silliman CC. Antibodies to major histocompatibility complex class II antigens directly prime neutrophils and cause acute lung injury in a two-event in vivo rat model. Transfusion. 2016 Dec;56(12):3004-3011. PubMed PMID: 27667662
• Slaughter AL, D'Alessandro A, Moore EE, Banerjee A, Silliman CC, Hansen KC, Reisz JA, Fragoso M, Wither MJ, Bacon AW, Moore HB, Peltz ED. Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma Acute Care Surg. 2016 Dec;81(6):1012-1019. PubMed PMID: 27602903
• Einersen PM, Moore EE, Chapman MP, Moore HB, Gonzalez E, Silliman CC, Banerjee A, Sauaia A. Rapid-thrombelastography (r-TEG) thresholds for goal-directed resuscitation of patients at risk for massive transfusion. J Trauma Acute Care Surg. 2016 Oct 31. [Epub ahead of print] PubMed PMID: 27805995
• Kelher MR, Banerjee A, Gamboni F, Anderson C, Silliman CC. Antibodies to major histocompatibility complex class II antigens directly prime neutrophils and cause acute lung injury in a two-event in vivo rat model. Transfusion. 2016 Sep 25. [Epub ahead of print] PubMed PMID: 27667662
• Slaughter AL, D'Alessandro A, Moore EE, Banerjee A, Silliman CC, Hansen KC, Reisz JA, Fragoso M, Wither MJ, Bacon A, Moore HB, Peltz ED. Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma Acute Care Surg. 2016 Sep 16. [Epub ahead of print] PubMed PMID: 27602903
• Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC. LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol. 2016 Aug 16. [Epub ahead of print] PubMed PMID: 27531930
• D'alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman CC, Banerjee A, Hansen KC. Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph. Blood Transfus. 2016 May;14(2):185-94. PubMed PMID: 27177401
• Kent MW, Kelher MR, Silliman CC, Quinones R. Neutrophil function in children following allogeneic hematopoietic stem cell transplant. Pediatr Transplant. 2016 Aug;20(5):658-66. PubMed PMID: 27114335
• Moore EE, Moore HB, Gonzalez E, Sauaia A, Banerjee A, Silliman CC. Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient. Transfusion. 2016 Apr;56 Suppl 2:S110-4. PubMed PMID: 27100746
• D'Alessandro A, Moore HB, Moore EE, Wither MJ, Nemkov T, Morton AP, Gonzalez E, Chapman MP, Fragoso M, Slaughter A, Sauaia A, Silliman CC, Hansen KC, Banerjee A. Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock. Shock. 2016 Aug;46(2):173-82. PubMed PMID: 26863033
• Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, Wohlauer MV, Barnett CC, Bensard DD, Biffl WL, Burlew CC, Johnson JL, Pieracci FM, Jurkovich GJ, Banerjee A, Silliman CC, Sauaia A. Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays. Ann Surg. 2016 Jun;263(6):1051-9. PubMed PMID: 26720428
• West FB, Kelher MR, Silliman CC: Red Blood Cell Transfusion in Moore HB, Gonzalez E, Moore EE Eds. The Acute Coagulopathy of Trauma. Berlin: Springer Verlag 2016.
• D'Alessandro A, Nemkov T, Kelher M, West FB, Schwindt RK, Banerjee A, Moore EE, Silliman CC, Hansen KC. Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion. 2015 Jun;55(6):1155-68. PubMed PMID: 25556331
• Dzieciatkowska M, D'Alessandro A, Burke TA, Kelher MR, Moore EE, Banerjee A, Silliman CC, West BF, Hansen KC. Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences. J Proteomics. 2015 Jan 1;112:190-209. PubMed PMID: 25201077
• D'Alessandro A, Hansen KC, Silliman CC, Moore EE, Kelher M, Banerjee A. Metabolomics of AS-5 RBC supernatants following routine storage. Vox Sang. 2015 Feb;108(2):131-40. PubMed PMID: 25200932
• Moore HB, Moore EE, Gonzalez E, Hansen KC, Dzieciatkowska M, Chapman MP, Sauaia A, West B, Banerjee A, Silliman CC. Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury. Shock. 2015 Jan;43(1):39-46. PubMed PMID: 25072794
• D'Alessandro A, Hansen KC, Silliman CC, Moore EE, Kelher M, Banerjee A. Metabolomics of AS-5 RBC supernatants following routine storage. Vox Sang. 2015 Feb;108(2):131-40. PubMed PMID: 25200932
• Moore HB, Moore EE, Gonzalez E, Hansen KC, Dzieciatkowska M, Chapman MP, Sauaia A, West B, Banerjee A, Silliman CC. Hemolysis exacerbates hyperfibrinolysis, whereas platelolysis shuts down fibrinolysis: evolving concepts of the spectrum of fibrinolysis in response to severe injury. Shock. 2015 Jan;43(1):39-46. PubMed PMID: 25072794
• Chapman MP, Moore EE, Moore HB, Gonzalez E, Gamboni F, Chandler JG, Mitra S, Ghasabyan A, Chin TL, Sauaia A, Banerjee A, Silliman CC. Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients. J Trauma Acute Care Surg. 2015 Oct 21. [Epub ahead of print] PubMed PMID: 26491796
• Chapman MP, Moore EE, Moore HB, Gonzalez E, Morton AP, Chandler J, Fleming CD, Ghasabyan A, Silliman CC, Banerjee A, Sauaia A. The "Black Diamond": Rapid thrombelastography identifies lethal hyperfibrinolysis. J Trauma Acute Care Surg. 2015 Oct 19. [Epub ahead of print] PubMed PMID: 26488324
• Moore HB, Moore EE, Chapman MP, Gonzalez E, Slaughter AL, Morton AP, D'Alessandro A, Hansen KC, Sauaia A, Banerjee A, Silliman CC. Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients. J Thromb Haemost. 2015 Oct;13(10):1878-87. PubMed PMID: 26256459
• D'Alessandro A, Slaughter AL, Peltz ED, Moore EE, Silliman CC, Wither M, Nemkov T, Bacon AW, Fragoso M, Banerjee A, Hansen KC. Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics. J Transl Med. 2015 Aug 5;13:253. PubMed PMID: 26242576
• Harr JN, Moore EE, Chin TL, Chapman MP, Ghasabyan A, Stringham JR, Banerjee A, Silliman CC. Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early. Eur J Trauma Emerg Surg. 2015 Feb;41(1):49-56. PubMed PMID: 26038165
• Moore EE, Moore HB, Gonzalez E, Chapman MP, Hansen KC, Sauaia A, Silliman CC, Banerjee A. Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid. J Trauma Acute Care Surg. 2015 Jun;78(6 Suppl 1):S65-9. PubMed PMID: 26002266
• Moore HB, Moore EE, Lawson PJ, Gonzalez E, Fragoso M, Morton AP, Gamboni F, Chapman MP, Sauaia A, Banerjee A, Silliman CC. Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock. Surgery. 2015 Aug;158(2):386-92. PubMed PMID: 25979440
• Bock A, Tucker N, Kelher MR, Khan SY, Gonzalez E, Wohlauer M, Hansen K, Dzieciatkowska M, Sauaia A, Banerjee A, Moore EE, Silliman CC. a-Enolase Causes Proinflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils Through Plasmin Activation of Protease-Activated Receptor 2. Shock. 2015 Aug;44(2):137-42. PubMed PMID: 25944790
• D'Alessandro A, Moore HB, Moore EE, Wither M, Nemkov T, Gonzalez E, Slaughter A, Fragoso M, Hansen KC, Silliman CC, Banerjee A. Early hemorrhage triggers metabolic responses that build up during prolonged shock. Am J Physiol Regul Integr Comp Physiol. 2015 Jun 15;308(12):R1034-44. PubMed PMID: 25876652
• Peltz ED, D'Alessandro A, Moore EE, Chin T, Silliman CC, Sauaia A, Hansen KC, Banerjee A. Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury. J Trauma Acute Care Surg. 2015 Apr;78(4):742-51. PubMed PMID: 25807403
• Chapman MP, Moore EE, Chin TL, Ghasabyan A, Chandler J, Stringham J, Gonzalez E, Moore HB, Banerjee A, Silliman CC, Sauaia A. Combat: Initial Experience with a Randomized Clinical Trial of Plasma-Based Resuscitation in the Field for Traumatic Hemorrhagic Shock. Shock. 2015 Aug;44 Suppl 1:63-70. PubMed PMID: 25784527
• Maloney JP, Ambruso DR, Voelkel NF, Silliman CC. Platelet Vascular Endothelial Growth Factor is a Potential Mediator of Transfusion-Related Acute Lung Injury. J Pulm Respir Med. 2014;4. PubMed PMID: 25705568
• Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg. 2014 Dec;77(6):811-7; discussion 817. PubMed PMID: 25051384
• Gamboni F, Escobar GA, Moore EE, Dzieciatkowska M, Hansen KC, Mitra S, Nydam TA, Silliman CC, Banerjee A. Clathrin complexes with the inhibitor kappa B kinase signalosome: imaging the interactome. Physiol Rep. 2014 Jul 1;2(7). PubMed PMID: 24994893
• Gonzalez E, Moore EE, Moore HB, Chapman MP, Silliman CC, Banerjee A. Trauma-Induced Coagulopathy: An Institution's 35 Year Perspective on Practice and Research. Scand J Surg. 2014 Apr 30;103(2):89-103. [Epub ahead of print] PubMed PMID: 24786172
• Kent MW, Kelher MR, West FB, Silliman CC. The pro-inflammatory potential of microparticles in red blood cell units. Transfus Med. 2014 Jun;24(3):176-81. PubMed PMID: 24786047
• Stringham JR, Moore EE, Gamboni F, Harr JN, Fragoso M, Chin TL, Carr CE, Silliman CC, Banerjee A. Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock. J Trauma Acute Care Surg. 2014 May;76(5):1214-21. PubMed PMID: 24747451
• Silliman CC, Kelher MR, Khan SY, LaSarre M, West FB, Land KJ, Mish B, Ceriano L, Sowemimo-Coker S. Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo. Blood. 2014 May 29;123(22):3488-95. PubMed PMID: 24747436
• Kent MW, Oliveira JL, Hoyer JD, Swanson KC, Kluge ML, Dawson DB, Liang X, Winkler TJ, Breaux CW Jr, LaCount R, Silliman CC. Hb Grand Junction (HBB: c.348_349delinsG; p.His117IlefsX42): a new hyperunstable hemoglobin variant. Hemoglobin. 2014;38(1):8-12. PubMed PMID: 24432801
• Silliman CC, Bercovitz RS, Khan SY, Kelher MR, LaSarre M, Land KJ, Sowemimo-Coker S. Antibodies to the HLA-A2 antigen prime neutrophils and serve as the second event in an in vitro model of transfusion-related acute lung injury. Vox Sang. 2014 Jul;107(1):76-82. PubMed PMID: 24372341
• Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Sauaia A, Banerjee A, Silliman CC. Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis. Shock. 2014 Jan;41(1):33-9. PubMed PMID: 24351527
• Moore EE, Chin TL, Chapman MC, Gonzalez E, Moore HB, Silliman CC, Hansen KC, Sauaia A, Banerjee A. Plasma first in the field for postinjury hemorrhagic shock. Shock. 2014 May;41 Suppl 1:35-8. PubMed PMID: 24317352
• D'Alessandro A, Nemkov T, Kelher M, West FB, Schwindt RK, Banerjee A, Moore EE, Silliman CC, Hansen KC. Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion. 2014 Dec 30. [Epub ahead of print] PubMed PMID: 25556331
• Wright FL, Gamboni F, Moore EE, Nydam TL, Mitra S, Silliman CC, Banerjee A. Hyperosmolarity invokes distinct anti-inflammatory mechanisms in pulmonary epithelial cells: evidence from signaling and transcription layers. PLoS One. 2014;9(12):e114129. PubMed PMID: 25479425
• Dzieciatkowska M, D'Alessandro A, Moore EE, Wohlauer M, Banerjee A, Silliman CC, Hansen KC. Lymph is not a plasma ultrafiltrate: a proteomic analysis of injured patients. Shock. 2014 Dec;42(6):485-98. PubMed PMID: 25243428
• D'Alessandro A, Dzieciatkowska M, Peltz ED, Moore EE, Jordan JR, Silliman CC, Banerjee A, Hansen KC. Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry. Shock. 2014 Dec;42(6):509-17. PubMed PMID: 25243424
• Dzieciatkowska M, D'Alessandro A, Burke TA, Kelher MR, Moore EE, Banerjee A, Silliman CC, West BF, Hansen KC. Proteomics of apheresis platelet supernatants during routine storage: Gender-related differences. J Proteomics. 2014 Sep 6;112C:190-209. [Epub ahead of print] PubMed PMID: 25201077
• Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Sauaia A, Banerjee A, Silliman CC. Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis. Shock. 2014 Jan;41(1):33-9. PubMed PMID: 24351527
• Kent MW, Oliveira JL, Hoyer JD, Swanson KC, Kluge ML, Dawson DB, Liang X, Winkler TJ, Breaux CW Jr, Lacount R, Silliman CC. Hb Grand Junction (HBB: c.348_349delinsG; p.His117IlefsX42): A New Hyperunstable Hemoglobin Variant. Hemoglobin. 2014;38(1):8-12. PubMed PMID: 24432801
• Silliman CC, Bercovitz RS, Khan SY, Kelher MR, Lasarre M, Land KJ, Sowemimo-Coker S. Antibodies to the HLA-A2 antigen prime neutrophils and serve as the second event in an in vitro model of transfusion-related acute lung injury. Vox Sang. 2013 Dec 30. [Epub ahead of print] PubMed PMID: 24372341
• Moore EE, Chin TL, Chapman MC, Gonzalez E, Moore HB, Silliman CC, Hansen KC, Sauaia A, Banerjee A. Plasma First in the Field for Postinjury Hemorrhagic Shock. Shock. 2013 Dec 5. [Epub ahead of print] PubMed PMID: 24317352
• Silliman CC. Platelet: RBC ratios: randomized controlled trials are needed for optimal resuscitation of injured patients. Crit Care Med. 2013 Dec;41(12):2834-5. PubMed PMID: 24275402
• Chapman MP, Moore EE, Ramos CR, Ghasabyan A, Harr JN, Chin TL, Stringham JR, Sauaia A, Silliman CC, Banerjee A. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg. 2013 Dec;75(6):961-7; discussion 967. PubMed PMID: 24256667
• Harr JN, Moore EE, Johnson JL, Chin TL, Wohlauer MV, Banerjee A, Silliman CC, Sauaia A. The authors reply. Crit Care Med. 2013 Aug;41(8):e189. PubMed PMID: 23863260
• West FB, Silliman CC. Transfusion-related acute lung injury: advances in understanding the role of proinflammatory mediators in its genesis. Expert Rev Hematol. 2013 Jun;6(3):265-76. PubMed PMID: 23782081
• Dzieciatkowska M, Silliman CC, Moore EE, Kelher MR, Banerjee A, Land KJ, Ellison M, West FB, Ambruso DR, Hansen KC. Proteomic analysis of the supernatant of red blood cell units: the effects of storage and leucoreduction. Vox Sang. 2013 Oct;105(3):210-8. PubMed PMID: 23663258
• Ramos CR, Moore EE, Manco-Johnson ML, Silliman CC, Chapman MC, Banerjee A. The incidence and magnitude of fibrinolytic activation in trauma patients: a rebuttal. J Thromb Haemost. 2013 Jul;11(7):1435-7. PubMed PMID: 23593973
• Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Banerjee A, Silliman CC, Sauaia A. Platelets are dominant contributors to hypercoagulability after injury. J Trauma Acute Care Surg. 2013 Mar;74(3):756-62; discussion 762-5. PubMed PMID: 23425732
• Ng C, Silliman CC, Pearl G, Smith W, Manco-Johnson M, Wang M. Treatment of refractory hemorrhage with Factor XIII in a patient with hemophilia A with inhibitor. Pediatr Blood Cancer. 2013 Jul;60(7):E23-5. PubMed PMID: 23382082
• Banerjee A, Moore EE, McLaughlin NJ, Lee L, Jones WL, Johnson JL, Nydam TL, Silliman CC. Hyperosmolarity attenuates TNF-a-mediated proinflammatory activation of human pulmonary microvascular endothelial cells. Shock. 2013 Apr;39(4):366-72. PubMed PMID: 23364439
• Lo KK, Bey EA, Patra B, Benson DD, Boothman DA, Silliman CC, Barnett CC Jr. Hemoglobin-based oxygen carrier mitigates transfusion-mediated pancreas cancer progression. Ann Surg Oncol. 2013 Jun;20(6):2073-7. PubMed PMID: 23328973
• Harr JN, Moore EE, Johnson J, Chin TL, Wohlauer MV, Maier R, Cuschieri J, Sperry J, Banerjee A, Silliman CC, Sauaia A. Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients. Crit Care Med. 2013 Feb;41(2):399-404. PubMed PMID: 23263579
• Harr JN, Moore EE, Ghasabyan A, Chin TL, Sauaia A, Banerjee A, Silliman CC. Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock. 2013 Jan;39(1):45-9. PubMed PMID: 23247121
• Morton AP, Moore EE, Wohlauer MV, Lo K, Silliman CC, Burlew CC, Banerjee A. Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding?. J Surg Res. 2013 Jan;179(1):5-9. PubMed PMID: 23138049
• Lee L, Moore EE, Hansen KC, Silliman CC, Chandler JG, Banerjee A. It's not your grandfather's field plasma. Surgery. 2013 Jun;153(6):857-60. PubMed PMID: 23122899
• Vetlesen A, Mirlashari MR, Akkök CA, Kelher MR, Khan SY, Silliman CC, Kjeldsen-Kragh J. Biological response modifiers in photochemically pathogen-reduced versus untreated apheresis platelet concentrates. Transfusion. 2013 Jan;53(1):147-55. PubMed PMID: 22563732
• Morton AP, Moore EE, Wohlauer MV, Lo K, Silliman CC, Burlew CC, Banerjee A. Revisiting early postinjury mortality: are they bleeding because they are dying or dying because they are bleeding?. J Surg Res. 2013 Jan;179(1):5-9. PubMed PMID: 23138049
• Vetlesen A, Mirlashari MR, Akkök CA, Kelher MR, Khan SY, Silliman CC, Kjeldsen-Kragh J. Biological response modifiers in photochemically pathogen-reduced versus untreated apheresis platelet concentrates. Transfusion. 2013 Jan;53(1):147-55. PubMed PMID: 22563732
• Pieracci FM, Barnett CC Jr, Townsend N, Moore EE, Johnson J, Biffl W, Bensard DD, Burlew CC, Gerber A, Silliman CC. Sexual dimorphism in hematocrit response following red blood cell transfusion of critically ill surgical patients. ISRN Hematol. 2012;2012:298345. PubMed PMID: 22536521
• Wohlauer MV, Moore EE, Thomas S, Sauaia A, Evans E, Harr J, Silliman CC, Ploplis V, Castellino FJ, Walsh M. Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg. 2012 May;214(5):739-46. PubMed PMID: 22520693
• Reesink HW, Lee J, Keller A, Dennington P, Pink J, Holdsworth R, Schennach H, Goldman M, Petraszko T, Sun J, Meng Y, Qian K, Rehacek V, Turek P, Krusius T, Juvonen E, Tiberghien P, Legrand D, Semana G, Muller JY, Bux J, Reil A, Lin CK, Daly H, McSweeney E, Porretti L, Greppi N, Rebulla P, Okazaki H, Sánchez-Guerrero SA, Baptista-González HA, Martínez-Murillo C, Guerra-Márquez A, Rodriguez-Moyado H, Middelburg RA, Wiersum-Osselton JC, Brand A, van Tilburg C, Dinesh D, Dagger J, Dunn P, Brojer E, Letowska M, Maslanka K, Lachert E, Uhrynowska M, Zhiburt E, Palfi M, Berlin G, Frey BM, Puig Rovira L, Muñiz-Diaz E, Castro E, Chapman C, Green A, Massey E, Win N, Williamson L, Silliman CC, Chaffin DJ, Ambruso DR, Blumberg N, Tomasulo P, Land KJ, Norris PJ, Illoh OC, Davey RJ, Benjamin RJ, Eder AF, McLaughlin L, Kleinman S, Panzer S. Measures to prevent transfusion-related acute lung injury (TRALI). Vox Sang. 2012 Oct;103(3):231-59. PubMed PMID: 22519920
• Tung JP, Fraser JF, Nataatmadja M, Colebourne KI, Barnett AG, Glenister KM, Zhou AY, Wood P, Silliman CC, Fung YL. Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI). Crit Care. 2012 Feb 1;16(1):R19. PubMed PMID: 22297161
• Benson DD, Beck AW, Burdine MS, Brekken R, Silliman CC, Barnett CC Jr. Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells. J Gastrointest Surg. 2012 Mar;16(3):460-8. PubMed PMID: 22246854
• Bercovitz RS, Kelher MR, Khan SY, Land KJ, Berry TH, Silliman CC. The pro-inflammatory effects of platelet contamination in plasma and mitigation strategies for avoidance. Vox Sang. 2012 May;102(4):345-53. PubMed PMID: 22092073
• Pezold M, Moore EE, Wohlauer M, Sauaia A, Gonzalez E, Banerjee A, Silliman CC. Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes. Surgery. 2012 Jan;151(1):48-54. PubMed PMID: 21899867
• Silliman CC, Dzieciatkowska M, Moore EE, Kelher MR, Banerjee A, Liang X, Land KJ, Hansen KC. Proteomic analyses of human plasma: Venus versus Mars. Transfusion. 2012 Feb;52(2):417-24. PubMed PMID: 21880043
• Lee L, Kelher MR, Moore EE, Banerjee A, Silliman CC. Hypertonic saline inhibits arachidonic acid priming of the human neutrophil oxidase. J Surg Res. 2012 May 1;174(1):24-8. PubMed PMID: 21816415
• Ball JB, Khan SY, McLaughlin NJ, Kelher MR, Nuss R, Cole L, Liang X, Silliman CC. A two-event in vitro model of acute chest syndrome: the role of secretory phospholipase A2 and neutrophils. Pediatr Blood Cancer. 2012 Mar;58(3):399-405. PubMed PMID: 21793188
• Lee L, Moore EE, Hansen KC, Silliman CC, Chandler JG, Banerjee A. It's not your grandfather's field plasma. Surgery. 2012 Nov 1. [Epub ahead of print] PubMed PMID: 23122899
• Silliman CC, Chaffin DJ. Broken hearts and transfusion-related acute lung injury. Crit Care Med. 2012 Oct;40(10):2909-10. PubMed PMID: 22986660
• Silliman CC. PLADO and kids: earlier/increased bleeding after HSCT. Blood. 2012 Jul 26;120(4):704-5. PubMed PMID: 22835886
• Harr JN, Moore EE, Stringham J, Wohlauer MV, Fragoso M, Jones WL, Gamboni F, Silliman CC, Banerjee A. Isoflurane prevents acute lung injury through ADP-mediated platelet inhibition. Surgery. 2012 Aug;152(2):270-6. PubMed PMID: 22828148
• Wohlauer M, Moore EE, Silliman CC, Fragoso M, Gamboni F, Harr J, Accurso F, Wright F, Haenel J, Fullerton D, Banerjee A. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53. PubMed PMID: 22732292
• Ellison MA, Ambruso DR, Silliman CC. Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. Curr Pharm Des. 2012;18(22):3255-9. PubMed PMID: 22621271
• Silliman CC, Kelher M, Ambruso DR. Bioactive lipids from stored cellular blood components: in vitro method is crucial for proper interpretation. Transfusion. 2012 May;52(5):1155-7; author reply 1157-8. PubMed PMID: 22571364
• Lee LL, Cothren-Burlew C, MD, Hansen K, Sauaia AQ, Silliman CC, Bannerjee A, Moore EE: It’s not your grandfather’s field plasma. Surgery EPub 9-1-2012, 2012.
• Gonzalez E, Moore EE, Wohlauer M, Silliman CC: Goal directed thromboprophylaxis in the Trauma Patient. In press: J. Trauma.
• Stringham JR, Moore EE, Gamboni F, Harr JN Fragoso M, Chin TL, Carr CE, Silliman CC, Banerjee A: Mesenteric Lymph Diversion Abrogates 5-Lipoxygenase Activation in the Kidney Following Trauma and Hemorrhagic Shock. In press J Trauma
• Harr J, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Sauaia A, Banerjee A, Silliman CC: Post-injury Hyperfibrinogenemia Compromises Efficacy of Heparin-Based VTE Prophylaxis. In press: J Trauma.
• West FB, Kelher MR, Silliman CC: Red Blood Cell Transfusion in Moore HB, Gonzalez E, Moore EE Eds. The Acute Coagulopathy of Trauma. Berlin: Springer Verlag in press
• Silliman CC, Burke T, Kelher MR: The Accumulation of Lipids and Proteins during Red Blood Cell Storage: the Roles of Leukoreduction and Experimental Filtration. In press: Blood Transfusion.
• Silliman CC: Perspective: AABB RBC Transfusion Triggers and Storage Age. Invited Editorial, In press: HemOnc Today.
• Silliman CC, Jones KL: Perspective: Association of Donor age and Sex with Recipient survival after RBC Transfusion. Invited Editorial, In press: HemOnc Today.
• Coleman JR, Moore EE, Silliman CC, Sauaia A: Tranexamic Acid Disturbs the Dynamics of Postinjury Fibrinolysis. In press: ANZ J. Surg.
• Hadley, JB, Kelher MR, D’Alessandro A, Gamboni F, Hansen K, Coleman J, Jones K, Cohen MJ, Moore EE, Banerjee A, Silliman CC: A pilot study of the metabolic profiles of apheresis platelets modified by donor age and sex and in vitro short-term incubation with sex hormones. In press: Transfusion.
• DeBot M, Eitel AP, Moore EE, Sauaia A, Lutz P, Schaid TR, Hadley JB, Kissau DJ, Cohen MJ, Kelher MR, Cohen, MJ, Silliman CC: Blood type O is a risk factor for hyperfibrinolysis and massive transfusion after severe injury. In press: Shock.
• Debot M, Mitra M, Lutz P, Schaid TR, Stafford P, Hadley JB, Hom P, Sauaia A, Silliman CC, Cohen MJ: Shock Induces Endothelial Permeability After Trauma Through Increased Activation of RhoA GTPase. In press: Shock.
• Cralley AI, Moore EE, Kissau D, Coleman JR, Vigneshwar N, DeBot M, Schaid TR, Moore HB, Cohen MJ, Hansen K, Silliman CC, Sauaia A, Fox CF: A combat casualty relevant dismounted complex blast injury model in swine. In Press: Shock.

Professional Memberships

• American Academy of Pediatrics (AAP), Fellow
• American Medical Association, Member
• American Association for the Advancement of Science, Member
• American Society of Hematology, Member
• American Association of Blood Banks, Member
• American Physiological Society, Member
• Federation of American Society for Experimental Biology, Member
• Society for Leukocyte Biology, Member

Practice Locations

• Children's Hospital Colorado

• Bonfils Blood Center
• Colorado Sickle Cell Treatment and Research Center

Specialty Information

• Pediatric Hematology / Oncology, Board Certification (1992)

• Blood / Lymphatic System - Blood Disorders
• Cancers
• Blood / Lymphatic System - Bleeding Disorders
• Cancers - Pediatric Cancer
• Blood / Lymphatic System