Barry Rumack, MD
Clinical Professor, Emergency Medicine-Medical Toxicology and Pharmacology

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Medical School:
  • MD, University of Wisconsin School of Medicine and Public Health (1968)
Undergraduate School:
  • BS, University of Chicago (IL) (1964)
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (1971)
  • University of Colorado, Medical Toxicology (1972)
Languages: English
Department: Emergency Medicine-Medical Toxicology and Pharmacology

Professional Titles

  • Professor Emeritus of Emergency Medicine and Pediatrics

Recognition & Awards

  • Prince Mahidol Award in the field of Public Health, Prince Mahidol Award Foundation (2023)
    Dr. Rumack is responsible for the creation of the iconic Rumack–Matthew nomogram, published in 1975. This nomogram, with its easy-to-understand graphs of paracetamol level, time after ingestion, and risk of liver toxicity, has allowed doctors all over the world to appropriately diagnose paracetamol toxicity. Through his study on the efficacy of N-acetylcysteine as its antidote, a treatment protocol was formed which became the global standard for managing paracetamol toxicity and led to a drastic reduction in liver failure from 54 percent to nearly 0 percent. Some version of this protocol is still used in emergency departments all across the world today. Over the past 4 decades, Dr. Rumack has continued to be an influential figure in the field of medical toxicology. He pioneered the use of Poisindex as a poison information database and heralded in the digital age for poison centers and hospitals throughout the world, enhancing the efficiency and accuracy of poison information retrieval and provision. His work with paracetamol toxicity also continued, resulting in ever-improving and more individualized patient management. His passion for science, and his innovative spirit, combined with his unwavering commitment to deliver the best treatment possible for patients have helped save lives, improve treatment outcomes, and inspire countless physicians to strive for the betterment of their own patients.
  • Career Achievement Award, American Academy of Clinical Toxicology, North American Congress of Clinical Toxicology,, American Academy of Clinical Toxicology (2011)
  • Matthew J. Ellenhorn Award and Lecture, American College of Medical Toxicology (2001)
  • Honorary Doctorate, Jagellonian University (1995)
  • Clinton Thienes, M.D., Award, American Academy of Clinical Toxicology (1991)
  • Annual Recognition Award of the American Association of Poison Control Centers, American Association of Poison Control Centers (1985)

Research Interests

Acetaminophen Overdose and General Medical Toxicology


  • Emeritus Professor (2014)
    School of Medicine, Emergency Medicine
    Emergency Medicine-Medical Toxicology and Pharmacology


  • Mutsaers A, Sivilotti MLA, Yarema MC, Green JP, Johnson DW, Rumack BH. Letter in response to the Letter to the Editor by Harmouche. Clin Toxicol (Phila). 2020 Mar;58(3):221-222. PubMed PMID: 31878797
  • Kang AM, Padilla-Jones A, Fisher ES, Akakpo JY, Jaeschke H, Rumack BH, Gerkin RD, Curry SC. The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers. J Med Toxicol. 2020 Apr;16(2):169-176. PubMed PMID: 31768936
  • White J, Weinstein SA, De Haro L, Bédry R, Schaper A, Rumack BH, Zilker T. Reply to Rzymski and Klimaszyk regarding comment on "Mushroom poisoning: A proposed new clinical classification". Toxicon. 2019 Mar 15;160:59. PubMed PMID: 30794842
  • Mutsaers A, Green JP, Sivilotti MLA, Yarema MC, Tucker D, Johnson DW, Spyker DA, Rumack BH. Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis. Clin Toxicol (Phila). 2019 Jun;57(6):380-386. PubMed PMID: 30689438
  • Akakpo JY, Ramachandran A, Duan L, Schaich MA, Jaeschke MW, Freudenthal BD, Ding WX, Rumack BH, Jaeschke H. Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase. Toxicol Sci. 2019 Jul 1;170(1):57-68. PubMed PMID: 30903181
  • White J, Weinstein SA, De Haro L, Bédry R, Schaper A, Rumack BH, Zilker T. Mushroom poisoning: A proposed new clinical classification. Toxicon. 2019 Jan;157:53-65. PubMed PMID: 30439442
  • Yarema M, Chopra P, Sivilotti MLA, Johnson D, Nettel-Aguirre A, Bailey B, Victorino C, Gosselin S, Purssell R, Thompson M, Spyker D, Rumack B. Correction to: Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning. J Med Toxicol. 2018 Jun;14(2):173. PubMed PMID: 29532341
  • Yarema M, Chopra P, Sivilotti MLA, Johnson D, Nettel-Aguirre A, Bailey B, Victorino C, Gosselin S, Purssell R, Thompson M, Spyker D, Rumack B. Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning. J Med Toxicol. 2018 Jun;14(2):120-127. PubMed PMID: 29423816
  • Akakpo JY, Ramachandran A, Kandel SE, Ni HM, Kumer SC, Rumack BH, Jaeschke H. 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. Hum Exp Toxicol. 2018 Dec;37(12):1310-1322. PubMed PMID: 29739258
  • Yarema MC, Sivilotti MLA, Nettel-Aguirre A, Rumack BH. Reply to: Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4?hours post-ingestion to rule out toxicity. Clin Toxicol (Phila). 2017 Jun;55(5):367. PubMed PMID: 28421843
  • Yarema MC, Green JP, Sivilotti ML, Johnson DW, Nettel-Aguirre A, Victorino C, Spyker DA, Rumack BH. Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine? . Clin Toxicol (Phila). 2017 Feb;55(2):102-108. PubMed PMID: 27788602
  • Lucyk SN, Yarema MC, Sivilotti ML, Johnson DW, Nettel-Aguirre A, Victorino C, Bailey B, Dart RC, Heard K, Spyker DA, Rumack BH. Outcomes of Patients With Premature Discontinuation of the 21-h Intravenous N-Acetylcysteine Protocol After Acute Acetaminophen Overdose. J Emerg Med. 2016 Apr;50(4):629-37. PubMed PMID: 26899513
  • Heard K, Rumack BH, Green JL, Bucher-Bartelson B, Heard S, Bronstein AC, Dart RC. A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning. Clin Toxicol (Phila). 2014 Jun;52(5):512-8. PubMed PMID: 24708414
  • Rumack B, Heard K, Green J, Albert D, Bucher-Bartelson B, Bodmer M, Sivilotti ML, Dart RC. Effect of therapeutic doses of acetaminophen (up to 4 g/day) on serum alanine aminotransferase levels in subjects consuming ethanol: systematic review and meta-analysis of randomized controlled trials. Pharmacotherapy. 2012 Sep;32(9):784-91. PubMed PMID: 22851428
  • Rumack BH, Bateman DN. Acetaminophen and acetylcysteine dose and duration: past, present and future. Clin Toxicol (Phila). 2012 Feb;50(2):91-8. PubMed PMID: 22320209
  • Dart RC, Rumack BH. Intravenous acetaminophen in the United States: iatrogenic dosing errors. Pediatrics. 2012 Feb;129(2):349-53. PubMed PMID: 22271694
  • Bronstein AC, Spyker DA, Cantilena LR Jr, Rumack BH, Dart RC. 2011 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 29th Annual Report. Clin Toxicol (Phila). 2012 Dec;50(10):911-1164. PubMed PMID: 23272763
  • Bronstein AC, Spyker DA, Cantilena LR Jr, Green JL, Rumack BH, Dart RC. 2010 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 28th Annual Report. Clin Toxicol (Phila). 2011 Dec;49(10):910-41. PubMed PMID: 22165864
  • Bronstein AC, Spyker DA, Cantilena LR Jr, Green JL, Rumack BH, Giffin SL. 2009 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th Annual Report. Clin Toxicol (Phila). 2010 Dec;48(10):979-1178. PubMed PMID: 21192756
  • Yarema MC, Johnson DW, Berlin RJ, Sivilotti ML, Nettel-Aguirre A, Brant RF, Spyker DA, Bailey B, Chalut D, Lee JS, Plint AC, Purssell RA, Rutledge T, Seviour CA, Stiell IG, Thompson M, Tyberg J, Dart RC, Rumack BH. Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 2009 Oct;54(4):606-14. PubMed PMID: 19556028
  • Bronstein AC, Spyker DA, Cantilena LR Jr, Green JL, Rumack BH, Giffin SL. 2008 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 26th Annual Report. Clin Toxicol (Phila). 2009 Dec;47(10):911-1084. PubMed PMID: 20028214
  • Dart RC, Paul IM, Bond GR, Winston DC, Manoguerra AS, Palmer RB, Kauffman RE, Banner W, Green JL, Rumack BH. Pediatric fatalities associated with over the counter (nonprescription) cough and cold medications. Ann Emerg Med. 2009 Apr;53(4):411-7. PubMed PMID: 19101060
  • Bronstein AC, Spyker DA, Cantilena LR Jr, Green JL, Rumack BH, Heard SE. 2007 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 25th Annual Report. Clin Toxicol (Phila). 2008 Dec;46(10):927-1057. PubMed PMID: 19065310
  • Dart RC, Rumack BH. Patient-tailored acetylcysteine administration. Ann Emerg Med. 2007 Sep;50(3):280-1. PubMed PMID: 17418449
  • Bronstein AC, Spyker DA, Cantilena LR Jr, Green J, Rumack BH, Heard SE. 2006 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS). Clin Toxicol (Phila). 2007 Dec;45(8):815-917. PubMed PMID: 18163234
  • White SJ, Rumack BH. The acetaminophen toxicity equations: "solutions" for acetaminophen toxicity based on the Rumack-Matthew nomogram. Ann Emerg Med. 2005 May;45(5):563-4. PubMed PMID: 15855961
  • Rumack BH. Acetaminophen misconceptions. Hepatology. 2004 Jul;40(1):10-5. PubMed PMID: 15239079
  • Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40(1):3-20. PubMed PMID: 11990202
  • Dart RC, Kuffner EK, Rumack BH. Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. Am J Ther. 2000 Mar;7(2):123-34. PubMed PMID: 11319580
  • Spyker DA, Harvey ED, Harvey BE, Harvey AM, Rumack BH, Peck CC, Atkinson AJ Jr, Woosley RL, Abernethy DR, Cantilena LR. Assessment and reporting of clinical pharmacology information in drug labeling. Clin Pharmacol Ther. 2000 Mar;67(3):196-200. PubMed PMID: 10741621
  • Rumack BH. Acetaminophen overdose? A quick answer. J Pediatr. 1999 Sep;135(3):269-70. PubMed PMID: 10484784
  • Hall AH, Rumack BH. Hydrogen sulfide poisoning: an antidotal role for sodium nitrite?. Vet Hum Toxicol. 1997 Jun;39(3):152-4. PubMed PMID: 9167244
  • Burkhart KK, Janco N, Kulig KW, Rumack BH. Cimetidine as adjunctive treatment for acetaminophen overdose. Hum Exp Toxicol. 1995 Mar;14(3):299-304. PubMed PMID: 7779462
  • Barron RA, Leaning J, Rumack BH. The catastrophe reaction syndrome: trauma in Tbilisi. Int J Law Psychiatry. 1993 Summer-Fall;16(3-4):403-26. PubMed PMID: 8125680
  • Montanio CD, Wruk KM, Kulig KW, Riggs BS, Rumack BH. Acute pediatric warfarin (Coumadin) ingestion: toxic effects despite early treatment. Am J Dis Child. 1993 Jun;147(6):609-10. PubMed PMID: 8506823
  • Forsyth JC, Mueller PD, Becker CE, Osterloh J, Benowitz NL, Rumack BH, Hall AH. Hydroxocobalamin as a cyanide antidote: safety, efficacy and pharmacokinetics in heavily smoking normal volunteers. J Toxicol Clin Toxicol. 1993;31(2):277-94. PubMed PMID: 8492341
  • Brent JA, Rumack BH. Role of free radicals in toxic hepatic injury. II. Are free radicals the cause of toxin-induced liver injury?. J Toxicol Clin Toxicol. 1993;31(1):173-96. PubMed PMID: 8433412
  • Brent JA, Rumack BH. Role of free radicals in toxic hepatic injury. I. Free radical biochemistry. J Toxicol Clin Toxicol. 1993;31(1):139-71. PubMed PMID: 8433411
  • Rumack CM, Rumack BH. Battery ingestions. Pediatrics. 1992 Apr;89(4 Pt 2):771-2. PubMed PMID: 1557276
  • Burkhart KK, Metcalf S, Shurnas E, O'Meara O, Brent J, Kulig K, Rumack BH. Exchange transfusion and multidose activated charcoal following vancomycin overdose. J Toxicol Clin Toxicol. 1992;30(2):285-94. PubMed PMID: 1588677
  • Hall AH, Smolinske SC, Stover B, Conrad FL, Rumack BH. Ibuprofen overdose in adults. J Toxicol Clin Toxicol. 1992;30(1):23-37. PubMed PMID: 1542147
  • Burkhart KK, Hall AH, Gerace R, Rumack BH. Hyperbaric oxygen treatment for carbon tetrachloride poisoning. Drug Saf. 1991 Sep-Oct;6(5):332-8. PubMed PMID: 1930739
  • Smilkstein MJ, Bronstein AC, Linden C, Augenstein WL, Kulig KW, Rumack BH. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med. 1991 Oct;20(10):1058-63. PubMed PMID: 1928874
  • Augenstein WL, Spoerke DG, Kulig KW, Hall AH, Hall PK, Riggs BS, el Saadi M, Rumack BH. Fluoride ingestion in children: a review of 87 cases. Pediatrics. 1991 Nov;88(5):907-12. PubMed PMID: 1945630
  • Brent J, Lucas M, Kulig K, Rumack BH. Methanol poisoning in a 6-week-old infant. J Pediatr. 1991 Apr;118(4 Pt 1):644-6. PubMed PMID: 1801762
  • Hall AH, Rumack BH. Methylene chloride exposure in furniture-stripping shops: ventilation and respirator use practices. J Occup Med. 1990 Jan;32(1):33-7. PubMed PMID: 2324841
  • Brent J, Vo N, Kulig K, Rumack BH. Reversal of prolonged isoniazid-induced coma by pyridoxine. Arch Intern Med. 1990 Aug;150(8):1751-3. PubMed PMID: 2152443
  • Smolinske SC, Scherger DL, Kearns PS, Wruk KM, Kulig KW, Rumack BH. Superwarfarin poisoning in children: a prospective study. Pediatrics. 1989 Sep;84(3):490-4. PubMed PMID: 2771552
  • DiNapoli J, Hall AH, Drake R, Rumack BH. Cyanide and arsenic poisoning by intravenous injection. Ann Emerg Med. 1989 Mar;18(3):308-11. PubMed PMID: 2538098
  • el Saadi MS, Hall AH, Hall PK, Riggs BS, Augenstein WL, Rumack BH. Hydrofluoric acid dermal exposure. Vet Hum Toxicol. 1989 Jun;31(3):243-7. PubMed PMID: 2741315
  • Johnson WS, Hall AH, Rumack BH. Cyanide poisoning successfully treated without 'therapeutic methemoglobin levels'. Am J Emerg Med. 1989 Jul;7(4):437-40. PubMed PMID: 2567600
  • Hall AH, Kulig KW, Rumack BH. Suspected cyanide poisoning in smoke inhalation: complications of sodium nitrite therapy. J Toxicol Clin Exp. 1989 Jan-Feb;9(1):3-9. PubMed PMID: 2746547
  • Hall AH, Kulig KW, Rumack BH. Toxic smoke inhalation. Am J Emerg Med. 1989 Jan;7(1):121-2. PubMed PMID: 2914036
  • Vandenberg SA, Smolinske SC, Spoerke DG, Rumack BH. Non-aspirin salicylates: conversion factors for estimating aspirin equivalency. Vet Hum Toxicol. 1989 Feb;31(1):49-50. PubMed PMID: 2652876
  • Riggs BS, Bronstein AC, Kulig K, Archer PG, Rumack BH. Acute acetaminophen overdose during pregnancy. Obstet Gynecol. 1989 Aug;74(2):247-53. PubMed PMID: 2748061
  • Spoerke DG, Vandenberg SA, Smolinske SC, Kulig K, Rumack BH. Eucalyptus oil: 14 cases of exposure. Vet Hum Toxicol. 1989 Apr;31(2):166-8. PubMed PMID: 2929128
  • Vandenberg SA, Kulig K, Spoerke DG, Hall AH, Bailie VJ, Rumack BH. Chlorambucil overdose: accidental ingestion of an antineoplastic drug. J Emerg Med. 1988 Nov-Dec;6(6):495-8. PubMed PMID: 3065402
  • Golightly LK, Smolinske SS, Bennett ML, Sutherland EW 3rd, Rumack BH. Pharmaceutical excipients. Adverse effects associated with 'inactive' ingredients in drug products (Part II). Med Toxicol Adverse Drug Exp. 1988 May-Jun;3(3):209-40. PubMed PMID: 3041246
  • Golightly LK, Smolinske SS, Bennett ML, Sutherland EW 3rd, Rumack BH. Pharmaceutical excipients. Adverse effects associated with inactive ingredients in drug products (Part I). Med Toxicol Adverse Drug Exp. 1988 Mar-Apr;3(2):128-65. PubMed PMID: 3287089
  • Augenstein WL, Kulig KW, Rumack BH. Captopril overdose resulting in hypotension. JAMA. 1988 Jun 10;259(22):3302-5. PubMed PMID: 3286910
  • Spoerke DG, Spoerke SE, Rumack BH. Berry identification using a modified botanic key. Vet Hum Toxicol. 1988 Jun;30(3):260-4. PubMed PMID: 3388755
  • Scherger DL, Wruk KM, Kulig KW, Rumack BH. Ethyl alcohol (ethanol)-containing cologne, perfume, and after-shave ingestions in children. Am J Dis Child. 1988 Jun;142(6):630-2. PubMed PMID: 3369402
  • Hall AH, Smolinske SC, Kulig KW, Rumack BH. Ibuprofen overdose--a prospective study. West J Med. 1988 Jun;148(6):653-6. PubMed PMID: 3176471
  • Smolinske SC, Spoerke DG, Spiller SK, Wruk KM, Kulig K, Rumack BH. Cigarette and nicotine chewing gum toxicity in children. Hum Toxicol. 1988 Jan;7(1):27-31. PubMed PMID: 3346035
  • Golightly LK, Davis AG, Budwitz WJ, Gelman CJ, Rathmann KL, Sutherland EW, Rumack BH. Documenting the activity and effectiveness of a regional drug information center. Am J Hosp Pharm. 1988 Feb;45(2):356-61. PubMed PMID: 3364436
  • Smilkstein MJ, Smolinske SC, Kulig KW, Rumack BH. Severe hypermagnesemia due to multiple-dose cathartic therapy. West J Med. 1988 Feb;148(2):208-11. PubMed PMID: 3348031
  • Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med. 1988 Dec 15;319(24):1557-62. PubMed PMID: 3059186
  • Smilkstein MJ, Steedle D, Kulig KW, Marx JA, Rumack BH. Magnesium levels after magnesium-containing cathartics. J Toxicol Clin Toxicol. 1988;26(1-2):51-65. PubMed PMID: 3385848
  • Spoerke DG, Murphy MM, Wruk KM, Rumack BH. Five cases of Thermopsis poisoning. J Toxicol Clin Toxicol. 1988;26(5-6):397-406. PubMed PMID: 3193493
  • Spoerke DG, Hall AH, Dodson CD, Stermitz FR, Swanson CH Jr, Rumack BH. Mystery root ingestion. J Emerg Med. 1987 Sep-Oct;5(5):385-8. PubMed PMID: 3668202
  • Spoerke DG, Spoerke SE, Rumack BH. International opinion concerning indications, safety and availability of poison centre antidotes and treatment. Hum Toxicol. 1987 Sep;6(5):361-4. PubMed PMID: 3679243
  • Golightly LK, Smolinske SC, Kulig KW, Wruk KM, Gelman CJ, Rumack BH, Linden CH. Clinical effects of accidental levothyroxine ingestion in children. Am J Dis Child. 1987 Sep;141(9):1025-7. PubMed PMID: 2887106
  • Augenstein WL, Kulig KW, Rumack BH. Acetaminophen levels. Ann Emerg Med. 1987 Sep;16(9):1096. PubMed PMID: 3631674
  • Duffens KR, Smilkstein MJ, Bessen HA, Rumack BH. Falsely elevated salicylate levels due to diflunisal overdose. J Emerg Med. 1987 Nov-Dec;5(6):499-503. PubMed PMID: 3429821
  • Riggs BS, Kulig K, Rumack BH. Current status of aspirin and acetaminophen intoxication. Pediatr Ann. 1987 Nov;16(11):886-98. PubMed PMID: 3320910
  • Hall AH, Kulig KW, Rumack BH. Acetaminophen and alcoholics. Dig Dis Sci. 1987 May;32(5):558. PubMed PMID: 3568944
  • Roberts RJ, Mirkin BL, Rumack BH. SI units and pediatric therapeutics. J Pediatr. 1987 Mar;110(3):494-5. PubMed PMID: 3819955
  • Spoerke DG, Spoerke SE, Hall A, Rumack BH. Toxicity of Cyclamen persium (Mill). Vet Hum Toxicol. 1987 Jun;29(3):250-1. PubMed PMID: 3604048
  • Hall AH, Kulig KW, Rumack BH. Intravenous epinephrine abuse. Am J Emerg Med. 1987 Jan;5(1):64-5. PubMed PMID: 3814285
  • Smilkstein MJ, Kulig KW, Rumack BH. Acute toxic blindness: unrecognized quinine poisoning. Ann Emerg Med. 1987 Jan;16(1):98-101. PubMed PMID: 3800084
  • Kulig KW, Bar-Or D, Rumack BH. Intravenous theophylline poisoning and multiple-dose charcoal in an animal model. Ann Emerg Med. 1987 Aug;16(8):842-6. PubMed PMID: 3619161
  • Hall AH, Spoerke DG, Rumack BH. Mushroom poisoning: identification, diagnosis, and treatment. Pediatr Rev. 1987 Apr;8(10):291-8. PubMed PMID: 3332331
  • Hall AH, Doutre WH, Ludden T, Kulig KW, Rumack BH. Nitrite/thiosulfate treated acute cyanide poisoning: estimated kinetics after antidote. J Toxicol Clin Toxicol. 1987;25(1-2):121-33. PubMed PMID: 3586082
  • Hall AH, Rumack BH. Hydroxycobalamin/sodium thiosulfate as a cyanide antidote. J Emerg Med. 1987;5(2):115-21. PubMed PMID: 3295013
  • Smilkstein MJ, Smolinske SC, Rumack BH. A case of MAO inhibitor/MDMA interaction: agony after ecstasy. J Toxicol Clin Toxicol. 1987;25(1-2):149-59. PubMed PMID: 2884326
  • Hall AH, Rumack BH. Clinical toxicology of cyanide. Ann Emerg Med. 1986 Sep;15(9):1067-74. PubMed PMID: 3526995
  • Hall AH, Kulig KW, Rumack BH. Acetaminophen hepatotoxicity. JAMA. 1986 Oct 10;256(14):1893-4. PubMed PMID: 3761493
  • Betts LS, Smilkstein MJ, Rumack BH, Cwinn A. Unrecognized ultraviolet-induced keratoconjunctivitis. Ann Emerg Med. 1986 Nov;15(11):1378. PubMed PMID: 3777606
  • Hall AH, Smolinske SC, Conrad FL, Wruk KM, Kulig KW, Dwelle TL, Rumack BH. Ibuprofen overdose: 126 cases. Ann Emerg Med. 1986 Nov;15(11):1308-13. PubMed PMID: 3777588
  • Hall AH, Spoerke DG, Rumack BH. Assessing mistletoe toxicity. Ann Emerg Med. 1986 Nov;15(11):1320-3. PubMed PMID: 2877602
  • Spoerke DG, Hall AH, Grimes MJ, Honea BN 3rd, Rumack BH. Human overdose with the veterinary tranquilizer xylazine. Am J Emerg Med. 1986 May;4(3):222-4. PubMed PMID: 3964361
  • Hall AH, Rumack BH. Management of acute acetaminophen overdose. Am Fam Physician. 1986 May;33(5):107-14. PubMed PMID: 3706091
  • Rumack BH. Acetaminophen overdose in children and adolescents. Pediatr Clin North Am. 1986 Jun;33(3):691-701. PubMed PMID: 3714342
  • Hall AH, Kulig KW, Rumack BH. Drug- and chemical-induced methaemoglobinaemia. Clinical features and management. Med Toxicol. 1986 Jul-Aug;1(4):253-60. PubMed PMID: 3537620
  • Hoidal CR, Hall AH, Robinson MD, Kulig K, Rumack BH. Hydrogen sulfide poisoning from toxic inhalations of roofing asphalt fumes. Ann Emerg Med. 1986 Jul;15(7):826-30. PubMed PMID: 3729106
  • Caldarola V, Hassett JM, Hall AH, Bronstein AB, Kulig KW, Rumack BH. Hemorrhagic pancreatitis associated with acetaminophen overdose. Am J Gastroenterol. 1986 Jul;81(7):579-82. PubMed PMID: 3717123
  • Spoerke DG, Smolinske SC, Wruk KM, Rumack BH. Infrequently used antidotes: indications and availability. Vet Hum Toxicol. 1986 Feb;28(1):69-75. PubMed PMID: 3010544
  • Hall AH, Linden CH, Kulig KW, Rumack BH. Cyanide poisoning from laetrile ingestion: role of nitrite therapy. Pediatrics. 1986 Aug;78(2):269-72. PubMed PMID: 2942834
  • Linden CH, Hall AH, Kulig KW, Rumack BH. Acute ingestions of boric acid. J Toxicol Clin Toxicol. 1986;24(4):269-79. PubMed PMID: 3746985
  • Rumack BH. Acetaminophen: acute overdose toxicity in children. Drug Intell Clin Pharm. 1985 Dec;19(12):911-2. PubMed PMID: 4085348
  • Kulig K, Golightly LK, Rumack BH. Levothyroxine overdose associated with seizures in a young child. JAMA. 1985 Oct 18;254(15):2109-10. PubMed PMID: 4046139
  • Mofenson H, Becker C, Kimbrough R, Lawrence R, Lovejoy F, Winters W, Carracio TR, Hardel LK, Rumack BH, Spyker D. Commentary on 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD). Vet Hum Toxicol. 1985 Oct;27(5):434-8. PubMed PMID: 4060565
  • Hall AH, Bronstein AC, Smolinske SC, Doutre' WH, Kulig KW, Rumack BH, Spoerke DG. Propylene glycol plasma level. Pediatrics. 1985 Oct;76(4):654. PubMed PMID: 4047817
  • Hall AH, Smolinske SC, Kulig KW, Rumack BH. Guanabenz overdose. Ann Intern Med. 1985 Jun;102(6):787-8. PubMed PMID: 3994191
  • Rumack BH. Ipecac use in the home. Pediatrics. 1985 Jun;75(6):1148. PubMed PMID: 2860634
  • Kulig K, Bar-Or D, Cantrill SV, Rosen P, Rumack BH. Management of acutely poisoned patients without gastric emptying. Ann Emerg Med. 1985 Jun;14(6):562-7. PubMed PMID: 2859819
  • Winkler JV, Kulig K, Rumack BH. Mothball differentiation: naphthalene from paradichlorobenzene. Ann Emerg Med. 1985 Jan;14(1):30-2. PubMed PMID: 3965000
  • Hall AH, Kulig KW, Rumack BH. Acute management of common illicit drug intoxications. Semin Adolesc Med. 1985 Dec;1(4):259-69. PubMed PMID: 3843490
  • Spoerke DG, Montanio CD, Rumack BH. Pediatric exposure to the houseplant Synadenium grantii. Vet Hum Toxicol. 1985 Aug;27(4):283-4. PubMed PMID: 4035955
  • Smilkstein MJ, Bronstein AC, Pickett HM, Rumack BH. Hyperbaric oxygen therapy for severe hydrogen sulfide poisoning. J Emerg Med. 1985;3(1):27-30. PubMed PMID: 4093555
  • Spoerke DG, Rumack BH. Blue-green algae poisoning. J Emerg Med. 1985;2(5):353-5. PubMed PMID: 3936874
  • Hall AH, Spoerke DG, Bronstein AC, Kulig KW, Rumack BH. Human ivermectin exposure. J Emerg Med. 1985;3(3):217-9. PubMed PMID: 2869080
  • Rumack BH. Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases. Am J Dis Child. 1984 May;138(5):428-33. PubMed PMID: 6711498
  • Linden CH, Rumack BH. Acetaminophen overdose. Emerg Med Clin North Am. 1984 Feb;2(1):103-19. PubMed PMID: 6394298
  • Linden CH, Rumack BH, Strehlke C. Monoamine oxidase inhibitor overdose. Ann Emerg Med. 1984 Dec;13(12):1137-44. PubMed PMID: 6391305
  • Linden CH, Rumack BH. Emesis for 'body packers'. JAMA. 1984 Apr 27;251(16):2083. PubMed PMID: 6708252
  • Rumack BH. Acetaminophen overdose. Am J Med. 1983 Nov 14;75(5A):104-12. PubMed PMID: 6359859
  • Rumack BH, Rumack CM. Disk battery ingestion. JAMA. 1983 May 13;249(18):2509-11. PubMed PMID: 6842756
  • Kulig K, Rumack CM, Rumack BH, Duffy JP. Disk battery ingestion. Elevated urine mercury levels and enema removal of battery fragments. JAMA. 1983 May 13;249(18):2502-4. PubMed PMID: 6341635
  • Linden CH, Mitchiner JC, Lindzon RD, Rumack BH. Cyclobenzaprine overdosage. J Toxicol Clin Toxicol. 1983 May;20(3):281-8. PubMed PMID: 6620442
  • Miller LF, Rumack BH. Clinical safety of high oral doses of acetylcysteine. Semin Oncol. 1983 Mar;10(1 Suppl 1):76-85. PubMed PMID: 6340205
  • Spyker DA, O'Dell RW, Cox DB, Conner CS, Rumack BH. Comparison of alphabetic and phonetic retrieval of online drug information. Am J Hosp Pharm. 1983 Jan;40(1):83-7. PubMed PMID: 6687415
  • Kulig K, Rumack BH. Efficacy of naloxone in clonidine poisoning. Am J Dis Child. 1983 Aug;137(8):807-8. PubMed PMID: 6869346
  • Kulig K, Rumack BH, Sullivan JB Jr, Brandt H, Spyker DA, Duffy JP, Shipe JR. Amoxapine overdose. Coma and seizures without cardiotoxic effects. JAMA. 1982 Sep 3;248(9):1092-4. PubMed PMID: 7109203
  • Sawyer DR, Conner CS, Rumack BH. Managing acute toxicity from nonprescription stimulants. Clin Pharm. 1982 Nov-Dec;1(6):529-33. PubMed PMID: 6764397
  • Rumack BH. Diapers and poisons. JAMA. 1982 Nov 5;248(17):2164. PubMed PMID: 7120646
  • Kulig K, Rumack BH, Rosen P. Gag reflex in assessing level of consciousness. Lancet. 1982 Mar 6;1(8271):565. PubMed PMID: 6120419
  • Kulig K, Duffy J, Rumack BH, Mauro R, Gaylord M. Naloxone for treatment of clonidine overdose. JAMA. 1982 Mar 26;247(12):1697. PubMed PMID: 7062477
  • Rumack BH, Rosen P. Poison centers and emergency departments: friends or foes?. Ann Emerg Med. 1982 Jul;11(7):388. PubMed PMID: 7091803
  • Kulig K, Rumack BH, Marx JA. Amoxapine and neurologic deficits. Ann Intern Med. 1982 Aug;97(2):286. PubMed PMID: 7103298
  • Harris JC, Rumack BH, Bregman DJ. Comparative efficacy of injectable calcium and magnesium salts in the therapy of hydrofluoric acid burns. Clin Toxicol. 1981 Sep;18(9):1027-32. PubMed PMID: 7318388
  • Snodgrass W, Sullivan JB Jr, Rumack BH, Hashimoto C. Mercury poisoning from home gold ore processing. Use of penicillamine and dimercaprol. JAMA. 1981 Oct 23-30;246(17):1929-31. PubMed PMID: 7288970
  • Simpson DL, Rumack BH. Methylenedioxyamphetamine. Clinical description of overdose, death, and review of pharmacology. Arch Intern Med. 1981 Oct;141(11):1507-9. PubMed PMID: 7283563
  • Rumack BH, Rosen P. Emesis: safe and effective. Ann Emerg Med. 1981 Oct;10(10):551. PubMed PMID: 7283227
  • Rumack CM, Guggenheim MA, Rumack BH, Peterson RG, Johnson ML, Braithwaite WR. Neonatal intracranial hemorrhage and maternal use of aspirin. Obstet Gynecol. 1981 Nov;58(5 Suppl):52S-6S. PubMed PMID: 7312229
  • Sullivan JB Jr, Rumack BH, Peterson RG. Acute carbamazepine toxicity resulting from overdose. Neurology. 1981 May;31(5):621-4. PubMed PMID: 7194979
  • Snodgrass W, Rumack BH, Peterson RG, Holbrook ML. Salicylate toxicity following therapeutic doses in young children. Clin Toxicol. 1981 Mar;18(3):247-59. PubMed PMID: 7237957
  • Harris JC, Rumack BH, Aldrich FD. Toxicology of urea formaldehyde and polyurethane foam insulation. JAMA. 1981 Jan 16;245(3):243-3. PubMed PMID: 7452848
  • Rumack BH, Meredith TJ, Peterson RG, Prescott LF, Vale JA. Panel discussion. Management of acetaminophen overdose. Arch Intern Med. 1981 Feb 23;141(3 Spec No):401-3. PubMed PMID: 7469634
  • Peterson RG, Rumack BH. Age as a variable in acetaminophen overdose. Arch Intern Med. 1981 Feb 23;141(3 Spec No):390-3. PubMed PMID: 7469631
  • Rumack BH, Peterson RC, Koch GG, Amara IA. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med. 1981 Feb 23;141(3 Spec No):380-5. PubMed PMID: 7469629
  • Snodgrass W, Rumack BH, Sullivan JB Jr, Peterson RG, Chase HP, Cotton EK, Sokol R. Selenium: childhood poisoning and cystic fibrosis. Clin Toxicol. 1981 Feb;18(2):211-20. PubMed PMID: 7226733
  • Kulig K, Rumack BH. Physostigmine and asystole. Ann Emerg Med. 1981 Apr;10(4):228-20. PubMed PMID: 7013575
  • Conner CS, Murphrey KJ, Sawyer D, Murakami K, Rumack BH, Ford PS. Drug information services for consumers and health professionals. Am J Hosp Pharm. 1980 Sep;37(9):1215-9. PubMed PMID: 7416177
  • Rumack BH. The poison control center: answers not antidotes. Hosp Pract. 1980 Oct;15(10):123-9. PubMed PMID: 7419229
  • Peterson RG, Simmons MA, Rumack BH, Levine RL, Brooks JG. Pharmacology of furosemide in the premature newborn infant. J Pediatr. 1980 Jul;97(1):139-43. PubMed PMID: 7381633
  • Rumack BH, Peterson RG. Acetaminophen toxicity. West J Med. 1980 Jan;132(1):61. PubMed PMID: 7376647
  • Moore RA, Rumack BH, Conner CS, Peterson RG. Naloxone: underdosage after narcotic poisoning. Am J Dis Child. 1980 Feb;134(2):156-8. PubMed PMID: 7352440
  • Rumack BH. Aspirin and acetaminophen. Clin Toxicol. 1979 Oct;15(3):313-40. PubMed PMID: 509895
  • Lumpkin J, Watanabe AS, Rumack BH, Peterson RG. Phenothiazine-induced ventricular tachycardia following acute overdose. JACEP. 1979 Nov;8(11):476-8. PubMed PMID: 315488
  • Herson VC, Schmitt BD, Rumack BH. Magical thinking and imipramine poisoning in two school-age children. JAMA. 1979 May 4;241(18):1926-7. PubMed PMID: 448804
  • Hooper RG, Conner CS, Rumack BH. Acute poisoning from over-the-counter sleep preparations. JACEP. 1979 Mar;8(3):98-100. PubMed PMID: 513426
  • Conner CS, Watanabe AS, Rumack BH. Drug information--the problems and some solutions. Drug Intell Clin Pharm. 1979 Feb;13(2):86-93. PubMed PMID: 10297376
  • Sullivan JB Jr, Rumack BH, Thomas H Jr, Peterson RG, Bryson P. Pennyroyal oil poisoning and hepatotoxicity. JAMA. 1979 Dec 28;242(26):2873-4. PubMed PMID: 513258
  • Harris JC, Rumack BH, Peterson RG, McGuire BM. Methemoglobinemia resulting from absorption of nitrates. JAMA. 1979 Dec 28;242(26):2869-71. PubMed PMID: 513256
  • Freed CR, Gerber JG, Gal J, Rumack BH, Nies AS. Hemoperfusion in drug overdose. JAMA. 1979 Apr 13;241(15):1575. PubMed PMID: 430707
  • Peterson RG, Rumack BH. Laetrile and pregnancy. Clin Toxicol. 1979;15(2):181-4. PubMed PMID: 509883
  • de Torrente A, Rumack BH, Blair DT, Anderson RJ. Fixed-bed uncoated charcoal hemoperfusion in the treatment of intoxications: animal and patient studies. Nephron. 1979;24(2):71-7. PubMed PMID: 492413
  • Blair D, Rumack BH, Peterson RG. Analysis for salicylic acid in serum by high-performance liquid chromatography. Clin Chem. 1978 Sep;24(9):1543-4. PubMed PMID: 688615
  • Rumack BH, Peterson RG. Acetaminophen overdose: incidence, diagnosis, and management in 416 patients. Pediatrics. 1978 Nov;62(5 Pt 2 Suppl):898-903. PubMed PMID: 724342
  • Rumack BH. Aspirin versus acetaminophen: a comparative view. Pediatrics. 1978 Nov;62(5 Pt 2 Suppl):943-6. PubMed PMID: 569271
  • Peterson RG, Rumack BH. Pharmacokinetics of acetaminophen in children. Pediatrics. 1978 Nov;62(5 Pt 2 Suppl):877-9. PubMed PMID: 364399
  • Bryson PD, Watanabe AS, Rumack BH, Murphy RC. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA. 1978 May 19;239(20):2157. PubMed PMID: 642161
  • Peterson RG, Rumack BH. Toxicity of acetaminophen overdose. JACEP. 1978 May;7(5):202-5. PubMed PMID: 651074
  • Slater GE, Rumack BH, Peterson RG. Podophyllin poisoning. Systemic toxicity following cutaneous application. Obstet Gynecol. 1978 Jul;52(1):94-6. PubMed PMID: 683634
  • Rumack BH, Ford P, Sbarbaro J, Bryson P, Winokur M. Regionalization of poison centers--a rational role model. Clin Toxicol. 1978;12(3):367-75. PubMed PMID: 657754
  • Peterson RG, Rumack BH. D-penicillamine therapy of acute arsenic poisoning. J Pediatr. 1977 Oct;91(4):661-6. PubMed PMID: 908992
  • Peterson RG, Rumack BH. Treating acute acetaminophen poisoning with acetylcysteine. JAMA. 1977 May 30;237(22):2406-7. PubMed PMID: 576943
  • Peterson RG, Rumack BH. N-acetylcysteine for acetaminophen overdosage (cont.). N Engl J Med. 1977 Mar 3;296(9):515. PubMed PMID: 834231
  • Welch TR, Rumack BH, Hammond K. Clonazepam overdose resulting in cyclic coma. Clin Toxicol. 1977;10(4):433-6. PubMed PMID: 862377
  • Blair D, Rumack BH. Acetaminophen in serum and plasma estimated by high-pressure liquid chromatography: a micro-scale method. Clin Chem. 1977;23(4):743-5. PubMed PMID: 844171
  • Rumack BH, Burrington JD. Caustic ingestions: a rational look at diluents. Clin Toxicol. 1977;11(1):27-34. PubMed PMID: 577479
  • Rumack BH. Hydrocarbon ingestions: an opinion. Bull Natl Clgh Poison Control Cent. 1976 May-Jun;:2-5. PubMed PMID: 958368
  • Rumack BH. Editorial: Physostigmine: rational use. JACEP. 1976 Jul;5(7):541-2. PubMed PMID: 940245
  • Rumack BH. Editorial: Emesis, charcoal and cathartics. JACEP. 1976 Jan;5(1):44-5. PubMed PMID: 933388
  • Anderson RJ, Potts DE, Gabow PA, Rumack BH, Schrier RW. Unrecognized adult salicylate intoxication. Ann Intern Med. 1976 Dec;85(6):745-8. PubMed PMID: 999110
  • Holtzman JL, Rumack BH, Erickson RR. Spectrophotometric and radiometric studies on the in vivo binding of phenobarbital to hepatic microsomes. Arch Biochem Biophys. 1976 Apr;173(2):710-9. PubMed PMID: 1275515
  • Rumack BH. POISINDEX: an emergency poison management system. Drug Inf J. 1975 May-Sep;9(2-3):171-80. PubMed PMID: 10236972
  • Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics. 1975 Jun;55(6):871-6. PubMed PMID: 1134886
  • Vestal RE, Rumack BH. Letter: Glutethimide dependence: phenobarbital treatment. Ann Intern Med. 1974 May;80(5):670. PubMed PMID: 4823827
  • Burks JS, Walker JE, Rumack BH, Ott JE. Tricyclic antidepressant poisoning. Reversal of coma, choreoathetosis, and myoclonus by physostigmine. JAMA. 1974 Dec 4;230(10):1405-7. PubMed PMID: 4479642
  • Rumack BH, Wolfe RR, Gilfrich H. Phenytoin (diphenylhydantoin) treatment of massive digoxin overdose. Br Heart J. 1974 Apr;36(4):405-8. PubMed PMID: 4842639
  • Rumack BH, Temple AR. Lomotil poisoning. Pediatrics. 1974 Apr;53(4):495-500. PubMed PMID: 4823325
  • Rumack BH, Anderson RJ, Wolfe R, Fletcher EC, Vestal BK. Ornade and anticholinergic toxicity: hypertension, hallucinations, and arrhythmias. Clin Toxicol. 1974;7(6):573-81. PubMed PMID: 4156509
  • Rosenblum ML, Reynolds AF Jr, Smith KA, Rumack BH, Walker MD. Chloroethyl-cyclohexyl-nitrosourea (CCNU) in the treatment of malignant brain tumors. J Neurosurg. 1973 Sep;39(3):306-14. PubMed PMID: 4354763
  • Rumack BH, Holtzman J, Chase HP. Hepatic drug metabolism and protein malnutrition. J Pharmacol Exp Ther. 1973 Sep;186(3):441-6. PubMed PMID: 4199525
  • Rumack BH. Anticholinergic poisoning: treatment with physostigmine. Pediatrics. 1973 Sep;52(3):449-51. PubMed PMID: 4147165
  • Hammond KB, Rumack BH, Rodgerson DO. Blood ethanol. A report of unusually high levels in a living patient. JAMA. 1973 Oct 1;226(1):63-4. PubMed PMID: 4801643
  • Rumack BH, Walravens PA. Neonatal withdrawal following maternal ingestion of ethchlorvynol (Placidyl). Pediatrics. 1973 Nov;52(5):714-6. PubMed PMID: 4744665
  • Holtzman JL, Rumack BH. Kinetic studies on the control of ethylmorphine N-demethylase. The role of ethylmorphine activation of reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase. Biochemistry. 1973 Jun 5;12(12):2309-13. PubMed PMID: 4710582
  • Holtzman JL, Rumack BH. The kinetics of ethylmorphine activation of the NADPH-cytochrome P-450 reductase activity of hepatic microsomes from male and female rats. Chem Biol Interact. 1971 Aug;3(4):279-81. PubMed PMID: 4399904
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Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045

Hospital Affiliation
  • University of Colorado Hospital
  • Children's Hospital Colorado

Specialty Information

  • Pediatrics, Board Certification
  • Medical Toxicology
  • Medical Toxicology, Board Certification (1975)
  • Pediatrics, Board Certification (1974)
Clinical Interests
Acetaminophen Toxicity, Pharmacokinetics

General Information

Medical Schools:
  • MD, University of Wisconsin School of Medicine and Public Health (1968)
Undergraduate Schools:
  • BS, University of Chicago (IL) (1964)
Residency Programs:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (1971)
  • University of Colorado, Medical Toxicology (1972)
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Languages: English
Department: Emergency Medicine-Medical Toxicology and Pharmacology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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