Martin Voskuil, PhD

Publications

• Honaker R. W., R. K. Dhiman, P. Narayanasamy, D. C. Crick & M. I. Voskuil. 2010. DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon. J Bacteriol. 192:6447-55. PMCID: PMC3008535.
• Jiang Z., M. P. Higgins, J. Whitehurst, K. O. Kisich, M. I. Voskuil, R. S. Hodges. 2011. Anti-tuberculosis Activity of a-Helical Antimicrobial Peptides: De novo Designed L- and D-Enantiomers Versus L- and D-LL-37. Protein Pept Lett. 18:241-52.
• Leistikow R. L., R. A. Morton, I. L. Bartek, I. Frimpong, K. Wagner & M. I. Voskuil. 2010. The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from non-respiring dormancy. J. Bacteriol. 192:1662-70.
• Voskuil M. I., I. L. Bartek, K. Visconti, & G. K. Schoolnik. 2011 The response of Mycobacterium tuberculosis to reactive oxygen and nitrogen species. Frontiers in Cellular and Infection Microbiology, In press.
• Voskuil MI. Mycobacterium tuberculosis cholesterol catabolism requires a new class of acyl coenzyme A dehydrogenase. J Bacteriol. 2013 Oct;195(19):4319-21. PubMed PMID: 23893117
• Tischler AD, Leistikow RL, Kirksey MA, Voskuil MI, McKinney JD. Mycobacterium tuberculosis requires phosphate-responsive gene regulation to resist host immunity. Infect Immun. 2013 Jan;81(1):317-28. PubMed PMID: 23132496
• Voskuil M. I., I. L. Bartek, K. Visconti, & G. K. Schoolnik. 2011 The response of Mycobacterium tuberculosis to reactive oxygen and nitrogen species. Frontiers in Cellular and Infection Microbiology. Front. Microbiol. 2:105. Epub May 13. PMCID: PMC3119406.
• Hamad, M. A., C. R. Austin, A. L. Stewart, M. Higgins, A. Vazquez-Torres, M. I. Voskuil. 2011. Adaptation and antibiotic tolerance of anaerobic Burkholderia pseudomallei. Antimicrob Agents Chemother. 55:3313-23. PMCID: PMC3122399.
• Jones-Carson, J. J. R. Laughlin, A. L. Stewart, M. I. Voskuil, & A. Vazquez-Torres. 2012. Nitric oxide-dependent killing of aerobic, anaerobic and persistent Burkholderia pseudomallei Nitric Oxide: Biology and Chemistry. In press.
• Austin CR, Goodyear AW, Bartek IL, Stewart A, Sutherland MD, Silva EB, Zweifel A, Vitko NP, Tuanyok A, Highnam G, Mittelman D, Keim P, Schweizer HP, Vázquez-Torres A, Dow SW, Voskuil MI. A Burkholderia pseudomallei colony variant necessary for gastric colonization. MBio. 2015 Feb 3;6(1). PubMed PMID: 25650400
• Jones-Carson, J. J., R. Laughlin, A. L. Stewart, M. I. Voskuil, & A. Vazquez-Torres. 2012. Nitric oxide-dependent killing of aerobic, anaerobic and persistent Burkholderia Pseudomallei, Nitric Oxide: Biology and Chemistry. Nitric Oxide. 27:25-31.
• Jones-Carson J, Zweifel AE, Tapscott T, Austin C, Brown JM, Jones KL, Voskuil MI, Vázquez-Torres A. Nitric oxide from IFN?-primed macrophages modulates the antimicrobial activity of ß-lactams against the intracellular pathogens Burkholderia pseudomallei and Nontyphoidal Salmonella. PLoS Negl Trop Dis. 2014 Aug;8(8):e3079. PubMed PMID: 25121731
• Brugarolas, P. F. Movahedzadeh, Y. Wang, N. Zhang, I. L. Bartek, Y. N. Gao, M. I. Voskuil, S. G. Franzblau, & C. He. 2012. The oxidation-sensing regulator (MosR) is a new redox dependent transcription factor in Mycobacterium tuberculosis. J. Biol. Chem. 287:37703-12.
• Bartek IL, Woolhiser LK, Baughn AD, Basaraba RJ, Jacobs WR Jr, Lenaerts AJ, Voskuil MI. Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence. MBio. 2014 Jun 3;5(3):e01106-14. PubMed PMID: 24895305
• Irwin SM, Gruppo V, Brooks E, Gilliland J, Scherman M, Reichlen MJ, Leistikow R, Kramnik I, Nuermberger EL, Voskuil MI, Lenaerts AJ. Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas. Antimicrob Agents Chemother. 2014 Jul;58(7):4026-34. PubMed PMID: 24798275
• Walter, N. D., G. M. Dolganov, B. J. Garcia, W. Worodria, A. Andama, A. Musisi, I. Ayakaka, T. T. Van, M. I. Voskuil, B. C. de Jong, R. M. Davis, T. E. Fingerlin, K. Kechris, C. Palmer, P. Nahid, C. L. Daley, M. Geraci, L. Huang, A. Cattamanchi, M. Strong, G. K. Schoolnik, J. L. Davis. 2015. Mycobacterium tuberculosis persisters emerge in sputum during treatment of human tuberculosis. J. Infect. Dis. In press.
• Tischler, A., R. L. Leistikow, M. Kirksey, M.I. Voskuil, & J. McKinney. 2013. Mycobacterium tuberculosis Requires Phosphate-Responsive Gene Regulation to Resist Host Immunity. Infect. Immun.81:317-28.
• Sohaskey C. D. & Voskuil, M.I. 2015. In vitro models that utilize hypoxia to induce non-replicating persistence in mycobacteria. Ch. 11. In “Mycobacteria Protocols”. Ed. T. Parish. Springer Science+Business Media, New York. In press.
• Voskuil, M. I. & L. S. Schlesinger. 2015. Towards resolving the paradox of the critical role of the DosR regulon in M. tuberculosis persistence and active disease. Am. J. Respir. Crit. Care Med. In press.
• Voskuil MI, Schlesinger LS. Toward Resolving the Paradox of the Critical Role of the DosR Regulon in Mycobacterium tuberculosis Persistence and Active Disease. Am J Respir Crit Care Med. 2015 May 15;191(10):1103-5. PubMed PMID: 25978571
• Sohaskey CD, Voskuil MI. In vitro models that utilize hypoxia to induce non-replicating persistence in Mycobacteria. Methods Mol Biol. 2015;1285:201-13. PubMed PMID: 25779317
• Walter ND, Dolganov GM, Garcia BJ, Worodria W, Andama A, Musisi E, Ayakaka I, Van TT, Voskuil MI, de Jong BC, Davidson RM, Fingerlin TE, Kechris K, Palmer C, Nahid P, Daley CL, Geraci M, Huang L, Cattamanchi A, Strong M, Schoolnik GK, Davis JL. Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis. J Infect Dis. 2015 Sep 15;212(6):990-8. PubMed PMID: 25762787
• Austin CR, Goodyear AW, Bartek IL, Stewart A, Sutherland MD, Silva EB, Zweifel A, Vitko NP, Tuanyok A, Highnam G, Mittelman D, Keim P, Schweizer HP, Vázquez-Torres A, Dow SW, Voskuil MI. A Burkholderia pseudomallei colony variant necessary for gastric colonization. MBio. 2015 Feb 3;6(1). PubMed PMID: 25650400
• Bartek IL, Reichlen MJ, Honaker RW, Leistikow RL, Clambey ET, Scobey MS, Hinds AB, Born SE, Covey CR, Schurr MJ, Lenaerts AJ, Voskuil MI. Antibiotic Bactericidal Activity Is Countered by Maintaining pH Homeostasis in Mycobacterium smegmatis. mSphere. 2016 Aug 24;1(4). PubMed PMID: 27579369
• Tischler AD, Leistikow RL, Ramakrishnan P, Voskuil MI, McKinney JD. Mycobacterium tuberculosis Phosphate Uptake System Component PstA2 Is Not Required for Gene Regulation or Virulence. PLoS One. 2016 Aug 24;11(8):e0161467. PubMed PMID: 27557082
• Garcia BJ, Loxton AG, Dolganov GM, Van TT, Davis JL, de Jong BC, Voskuil MI, Leach SM, Schoolnik GK, Walzl G, Strong M, Walter ND. Sputum is a surrogate for bronchoalveolar lavage for monitoring Mycobacterium tuberculosis transcriptional profiles in TB patients. Tuberculosis (Edinb). 2016 Sep;100:89-94. PubMed PMID: 27553415
• Walter ND, de Jong BC, Garcia BJ, Dolganov GM, Worodria W, Byanyima P, Musisi E, Huang L, Chan ED, Van TT, Antonio M, Ayorinde A, Kato-Maeda M, Nahid P, Leung AM, Yen A, Fingerlin TE, Kechris K, Strong M, Voskuil MI, Davis JL, Schoolnik GK. Adaptation of Mycobacterium tuberculosis to Impaired Host Immunity in HIV-Infected Patients. J Infect Dis. 2016 Oct 15;214(8):1205-11. PubMed PMID: 27534685
• Irwin SM, Prideaux B, Lyon ER, Zimmerman MD, Brooks EJ, Schrupp CA, Chen C, Reichlen MJ, Asay BC, Voskuil MI, Nuermberger EL, Andries K, Lyons MA, Dartois V, Lenaerts AJ. Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice. ACS Infect Dis. 2016 Apr 8;2(4):251-267. PubMed PMID: 27227164
• Reichlen MJ, Leistikow RL, Scobey MS, Born SEM, Voskuil MI. Anaerobic Mycobacterium tuberculosis Cell Death Stems from Intracellular Acidification Mitigated by the DosR Regulon. J Bacteriol. 2017 Dec 1;199(23). PubMed PMID: 28874407
• Tuberculosis (Edinb). 2017 May;104:58-64. doi: 10.1016/j.tube.2017.03.001. Epub 2017 Mar 4. Significant under expression of the DosR regulon in M. tuberculosis complex lineage 6 in sputum. Ofori-Anyinam B1, Dolganov G2, Van T2, Davis JL3, Walter ND4, Garcia BJ5, Voskuil M6, Fissette K7, Diels M7, Driesen M7, Meehan CJ7, Yeboah-Manu D8, Coscolla M9, Gagneux S9, Antonio M10, Schoolnik G2, Gehre F1, de Jong BC11.
• Voskuil MI, Covey CR, Walter ND. Antibiotic Lethality and Membrane Bioenergetics. Adv Microb Physiol. 2018;73:77-122. PubMed PMID: 30262111
• Alqaseer K, Turapov O, Barthe P, Jagatia H, De Visch A, Roumestand C, Wegrzyn M, Bartek IL, Voskuil MI, O'Hare HM, Ajuh P, Bottrill AR, Witney AA, Cohen-Gonsaud M, Waddell SJ, Mukamolova GV. Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112. Mol Microbiol. 2019 Dec;112(6):1847-1862. PubMed PMID: 31562654
• Flores-Valdez MA, Aceves-Sánchez MJ, Peterson EJR, Baliga N, Bravo-Madrigal J, De la Cruz-Villegas MÁ, Ares MA, Born S, Voskuil M, Pérez-Padilla NA, Burciaga-Flores M, Camacho-Villegas TA, Espinoza-Jorge MG. Transcriptional portrait of M. bovis BCG during biofilm production shows genes differentially expressed during intercellular aggregation and substrate attachment. Sci Rep. 2020 Jul 28;10(1):12578. PubMed PMID: 32724037
• Musisi E, Dide-Agossou C, Al Mubarak R, Rossmassler K, Ssesolo AW, Kaswabuli S, Byanyima P, Sanyu I, Zawedde J, Worodria W, Voskuil MI, Savic RM, Nahid P, Davis JL, Huang L, Moore CM, Walter ND. Reproducibility of the Ribosomal RNA Synthesis Ratio in Sputum and Association with Markers of Mycobacterium tuberculosis Burden. Microbiol Spectr. 2021 Oct 31;9(2):e0048121. PubMed PMID: 34494858
• Walter ND, Born SEM, Robertson GT, Reichlen M, Dide-Agossou C, Ektnitphong VA, Rossmassler K, Ramey ME, Bauman AA, Ozols V, Bearrows SC, Schoolnik G, Dolganov G, Garcia B, Musisi E, Worodria W, Huang L, Davis JL, Nguyen NV, Nguyen HV, Nguyen ATV, Phan H, Wilusz C, Podell BK, Sanoussi ND, de Jong BC, Merle CS, Affolabi D, McIlleron H, Garcia-Cremades M, Maidji E, Eshun-Wilson F, Aguilar-Rodriguez B, Karthikeyan D, Mdluli K, Bansbach C, Lenaerts AJ, Savic RM, Nahid P, Vásquez JJ, Voskuil MI. Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens. Nat Commun. 2021 May 18;12(1):2899. PubMed PMID: 34006838
• Grosse-Siestrup BT, Gupta T, Helms S, Tucker SL, Voskuil MI, Quinn FD, Karls RK. A Role for Mycobacterium tuberculosis Sigma Factor C in Copper Nutritional Immunity. Int J Mol Sci. 2021 Feb 20;22(4). PubMed PMID: 33672733
• Dide-Agossou C, Bauman AA, Ramey ME, Rossmassler K, Al Mubarak R, Pauly S, Voskuil MI, Garcia-Cremades M, Savic RM, Nahid P, Moore CM, Tasneen R, Nuermberger EL, Robertson GT, Walter ND. Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0231021. PubMed PMID: 35311519
• Reichlen, M. J., S. E. M. Born, M. A. Lyons, K. Rossmassler, J. Reid, G. T. Robertson, N. D. Walter, M. I. Voskuil. 2023. Standardized RS ratio metrics to assess tuberculosis antimicrobial efficacy and potency. Antimicrob Agents Chemother. in press.
• Wynn EA, Dide-Agossou C, Reichlen M, Rossmassler K, Al Mubarak R, Reid JJ, Tabor ST, Born SEM, Ransom MR, Davidson RM, Walton KN, Benoit JB, Hoppers A, Loy DE, Bauman AA, Massoudi LM, Dolganov G, Strong M, Nahid P, Voskuil MI, Robertson GT, Moore CM, Walter ND. Transcriptional adaptation of Mycobacterium tuberculosis that survives prolonged multi-drug treatment in mice. mBio. 2023 Oct 31;14(6):e0236323. [Epub ahead of print] PubMed PMID: 37905920
• Born SEM, Reichlen MJ, Bartek IL, Benoit JB, Frank DN, Voskuil MI. Population heterogeneity in Mycobacterium smegmatis and Mycobacterium abscessus. Microbiology (Reading). 2023 Oct;169(10). PubMed PMID: 37862100
• Walter ND, Ernest JP, Dide-Agossou C, Bauman AA, Ramey ME, Rossmassler K, Massoudi LM, Pauly S, Al Mubarak R, Voskuil MI, Kaya F, Sarathy JP, Zimmerman MD, Dartois V, Podell BK, Savic RM, Robertson GT. Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses. Antimicrob Agents Chemother. 2023 Sep 19;67(9):e0028423. PubMed PMID: 37565762
• Wynn EA, Dide-Agossou C, Reichlen M, Rossmassler K, Al Mubarak R, Reid JJ, Tabor ST, Born SEM, Ransom MR, Davidson RM, Walton KN, Benoit JB, Hoppers A, Bauman AA, Massoudi LM, Dolganov G, Nahid P, Voskuil MI, Robertson GT, Moore CM, Walter ND. Transcriptional adaptation of drug-tolerant Mycobacterium tuberculosis in mice. bioRxiv. 2023 Mar 8. PubMed PMID: 36945388
• Reichlen MJ, Born SEM, Lyons MA, Rossmassler K, Reid J, Robertson GT, Walter ND, Voskuil MI. Standardized RS Ratio Metrics To Assess Tuberculosis Antimicrobial Efficacy and Potency. Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0148322. PubMed PMID: 36622159

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Specialty Information

Specialties

• Allergy and Immunology