Edwin deZoeten, MD, PhD
Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition
Medical School:
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition
- MD, University of Illinois College of Medicine (2001)
- PhD, University of Illinois At Chicago (2001)
- BS, University of Wisconsin–Madison (WI) (1992)
- University of Colorado (University Hospital) Program (2002)
- University of Colorado (University Hospital) Program, Pediatrics (2004)
- University of Pennsylvania/Children's Hospital of Philadelphia Program, Pediatric Gastroenterology (2004)
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition
Professional Titles
- Director-Pediatric Inflammatory Bowel Disease Center
- Associate Professor-Pediatrics
Publications
- Cheung T, de Zoeten EF, Hoffenberg EJ, Liu E, Pan Z, Walker T, Stahl M. Characteristics of Children with Inflammatory Bowel Disease and Coexisting Celiac Disease Seropositivity. J Pediatr Gastroenterol Nutr. 2022 Sep 19. [Epub ahead of print] PubMed PMID: 36122373
- Constant BD, de Zoeten EF, Weinman JP, Albenberg L, Scott FI. Early Anti-Tumor-Necrosis-Factor Therapy for Crohn's Disease-Related Abdominal Abscesses and Phlegmon in Children. Dig Dis Sci. 2022 Jul 5. [Epub ahead of print] PubMed PMID: 35790702
- Constant BD, de Zoeten EF, Stahl MG, Vajravelu RK, Lewis JD, Fennimore B, Gerich ME, Scott FI. Delays Related to Prior Authorization in Inflammatory Bowel Disease. Pediatrics. 2022 Mar 1;149(3). PubMed PMID: 35190811
- Nicholson MR, Alexander E, Ballal S, Davidovics Z, Docktor M, Dole M, Gisser JM, Goyal A, Hourigan SK, Jensen MK, Kaplan JL, Kellermayer R, Kelsen JR, Kennedy MA, Khanna S, Knackstedt ED, Lentine J, Lewis JD, Michail S, Mitchell PD, Oliva-Hemker M, Patton T, Queliza K, Sidhu S, Solomon AB, Suskind DL, Weatherly M, Werlin S, de Zoeten EF, Kahn SA. Efficacy and Outcomes of Faecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection in Children with Inflammatory Bowel Disease. J Crohns Colitis. 2022 Jun 24;16(5):768-777. PubMed PMID: 34788420
- Constant BD, Dutmer CM, Arnold MA, Hall C, Abbott JK, de Zoeten EF. Cytotoxic T-Lymphocyte-Associated Antigen 4 Haploinsufficiency Mimics Difficult-to-Treat Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2022 Apr;20(4):e696-e702. PubMed PMID: 33965572
- McLaughlin L, DeZoeten E, Verneris MR. Can allogeneic haematopoietic cell transplantation be curative in classical Crohn's disease? Br J Haematol. 2022 Nov 9. doi: 10.1111/bjh.18551. Epub ahead of print. PMID: 36352551.
- Mulberg AE, Conklin LS, Croft NM; I-ACT for Children Pediatric Extrapolation Working Group. Pediatric Extrapolation of Adult Efficacy to Children Is Critical for Efficient and Successful Drug Development. Gastroenterology. 2022 Jul;163(1):77-83. doi: 10.1053/j.gastro.2022.03.018. Epub 2022 Mar 12. PMID: 35288113.
- Constant BD, Dutmer CM, Arnold MA, Hall C, Abbott JK, de Zoeten EF. Cytotoxic T-Lymphocyte-Associated Antigen 4 Haploinsufficiency Mimics Difficult-to-Treat Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2021 May 7. [Epub ahead of print] PubMed PMID: 33965572
- Nicholson, M.R., Alexander, E., Davidovics, Z., Docktor,M., Dole, M. , Gisser,J.M. Goyal, A., Hourigan, S.K., Jensen, M.K., Kaplan, J., Kellermayer, R., Khanna, S., Knackstedt,E.D., Lentine, J., Lewis, J.D., Michail, S., Mitchell, P.D., Patton, T., Oliva-Hemker,M., Queliza,K., Sidhu, S., Solomon, Suskind, D.L., Weatherly, D., Werlin, S., de Zoeten, E.F. and Kahn, S. (2021) Efficacy and Outcomes of Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection in Children with Inflammatory Bowel Disease J. Crohns and Colitis
- Constant B.D., de Zoeten, E.F., Stahl, M.G., Vajravelu, R.K., Lewis, J.D., Fennimore, B., Gerich, M.E., Scott, F.I. (2021) Prior Authorization Requirements Delay Biologic Initiation and Increase Serious Adverse Events in Pediatric Inflammatory Bowel Disease. Pediatrics
- Mehta P, Pan Z, Furuta GT, Kim DY, de Zoeten E. Parent Perspectives on Exclusive Enteral Nutrition for the Treatment of Pediatric Crohn's Disease. J Pediatr Gastroenterol Nutr. 2020 Jul 24. [Epub ahead of print] PubMed PMID: 32910623
- deZoeten EF, Battista KD, Colson SB, Lovell MA, Kessler BE, Isfort RW, Fennimore BP, Onyiah JC, Kao DJ, Yeckes A, Keely S, Murray M, Hoffenberg EJ, Colgan SP, Gerich ME. Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease. Hypoxia (Auckl). 2020;8:1-12. PubMed PMID: 32104717
- NASPGHAN-IBD Committee Compilation of Resources and Recommendations for The IBD Provider. June 2020 https://naspghan.org/wp-content/uploads/2020/04/NASPGHAN-COVID19-and-IBD-Final-V3.pdf
- de Zoeten, E.F., Lawton, R (2020) COVID-19: What Pediatric IBD Patients And Caregivers Need To Know; August 2020 https://gikids.org/all/new-webinar-covid-19-and-pediatric-crohns-disease-and-ulcerative-colitis/
- de Zoeten, E.F., Gold, B., Benchimol, E. Kaplan, G.COVID-19: Families and Children with IBD Webinar. https://crohnsandcolitis.ca/About-Crohn-s-Colitis/COVID-19-and-IBD/COVID-19-Webinars
- Mehta P, Pan Z, Furuta GT, Kim DY, de Zoeten EF. Parent Perspectives on Exclusive Enteral Nutrition for the Treatment of Pediatric Crohn Disease. J Pediatr Gastroenterol Nutr. 2020 Dec;71(6):744-748. PubMed PMID: 32910623
- Olbrich CL, Simerly L, de Zoeten EF, Furuta GT, Spencer LA. Climbing New Mountains: How Antibodies Blocking a4ß7 Integrins Tamed Eosinophilic Inflammation of the Intestinal Tract. Dig Dis Sci. 2019 Jul 4. [Epub ahead of print] PubMed PMID: 31273593
- Denson LA, Curran M, McGovern DPB, Koltun WA, Duerr RH, Kim SC, Sartor RB, Sylvester FA, Abraham C, de Zoeten EF, Siegel CA, Burns RM, Dobes AM, Shtraizent N, Honig G, Heller CA, Hurtado-Lorenzo A, Cho JH. Challenges in IBD Research: Precision Medicine. Inflamm Bowel Dis. 2019 May 16;25(Supplement_2):S31-S39. PubMed PMID: 31095701
- Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. Correction: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 3;216(6):1465. PubMed PMID: 31088899
- Sanctuary MR, Huang RH, Jones AA, Luck ME, Aherne CM, Jedlicka P, de Zoeten EF, Collins CB. miR-106a deficiency attenuates inflammation in murine IBD models. Mucosal Immunol. 2019 Jan;12(1):200-211. PubMed PMID: 30327532
- Brumbaugh D, de Zoeten E, Dominguez S. Reply. J Pediatr. 2018 May 18. [Epub ahead of print] PubMed PMID: 29784510
- Hoffenberg EJ, McWilliams SK, Mikulich-Gilbertson SK, Murphy BV, Lagueux M, Robbins K, Hoffenberg AS, de Zoeten E, Hopfer CJ. Marijuana Use by Adolescents and Young Adults with Inflammatory Bowel Disease. J Pediatr. 2018 Apr 16. [Epub ahead of print] PubMed PMID: 29673723
- Sanctuary MR, Huang RH, Jones AA, Luck ME, Aherne CM, Jedlicka P, de Zoeten EF, Collins CB. miR-106a deficiency attenuates inflammation in murine IBD models. Mucosal Immunol. 2018 Oct 16. [Epub ahead of print] PubMed PMID: 30327532
- Collins CB, Puthoor PR, Nguyen TT, Jedlicka P, Friedman JE, de Zoeten EF. C/EBPß deletion promotes expansion of poorly functional intestinal regulatory T cells. J Crohns Colitis. 2018 Jul 31. [Epub ahead of print] PubMed PMID: 30085016
- Brumbaugh DE, De Zoeten EF, Pyo-Twist A, Fidanza S, Hughes S, Dolan SA, Child J, Dominguez SR. An Intragastric Fecal Microbiota Transplantation Program for Treatment of Recurrent Clostridium difficile in Children is Efficacious, Safe, and Inexpensive. J Pediatr. 2018 Mar;194:123-127.e1. PubMed PMID: 29198534
- Mark J, Fernando SD, Masterson JC, Pan Z, Capocelli KE, Furuta GT, de Zoeten EF. Clinical Implications of Pediatric Colonic Eosinophilia. J Pediatr Gastroenterol Nutr. 2018 May;66(5):760-766. PubMed PMID: 29095349
- Leinwand KL, Jones AA, Huang RH, Jedlicka P, Kao DJ, de Zoeten EF, Ghosh S, Moaddel R, Wehkamp J, Ostaff MJ, Bader J, Aherne CM, Collins CB. Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn's Disease. J Crohns Colitis. 2017 Jul 17. [Epub ahead of print] PubMed PMID: 28981653
- MacManus CF, Collins CB, Nguyen TT, Alfano RW, Jedlicka P, de Zoeten EF. VEN-120, a Recombinant Human Lactoferrin, Promotes a Regulatory T Cell [Treg] Phenotype and Drives Resolution of Inflammation in Distinct Murine Models of Inflammatory Bowel Disease. J Crohns Colitis. 2017 Sep 1;11(9):1101-1112. PubMed PMID: 28472424
- Noel G, Diamond B, Auerbach S, de Zoeten E, Hoffenberg E. Colonic Crohn Disease After Cardiac Transplantation: Case Report and Literature Review. J Pediatr Gastroenterol Nutr. 2017 Aug;65(2):e45-e46. PubMed PMID: 26655937
- Mark J, Fernando SD, Masterson JC, Pan Z, Capocelli KE, Furuta GT, de Zoeten EF. Clinical Implications of Pediatric Colonic Eosinophilia. J Pediatr Gastroenterol Nutr. 2017 Oct 31. [Epub ahead of print] PubMed PMID: 29095349
- Masterson JC, Capocelli KE, Hosford L, Biette K, McNamee EN, de Zoeten EF, Harris R, Fernando SD, Jedlicka P, Protheroe C, Lee JJ, Furuta GT. Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis. Inflamm Bowel Dis. 2015 Oct;21(10):2429-40. PubMed PMID: 26218140
- Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 May;8(3):699. PubMed PMID: 25943416
- Nagy-Szakal D, Mir SA, Harris RA, Dowd SE, Yamada T, Lacorazza HD, Tatevian N, Smith CW, de Zoeten EF, Klein J, Kellermayer R. Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis. FASEB J. 2015 Aug;29(8):3151-9. PubMed PMID: 25903104
- Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 Nov;8(6):1324-38. PubMed PMID: 25850656
- Noel G, Diamond B, Auerbach S, de Zoeten E, Hoffenberg E. Colonic Crohn's Disease after Cardiac Transplantation: Case Report and Literature Review. J Pediatr Gastroenterol Nutr. 2015 Dec 10. [Epub ahead of print] PubMed PMID: 26655937
- Shin DS, Jordan A, Basu S, Thomas RM, Bandyopadhyay S, de Zoeten EF, Wells AD, Macian F. Regulatory T cells suppress CD4 T cells through NFAT-dependent transcriptional mechanisms. EMBO Rep. 2014 Sep;15(9):991-9. PubMed PMID: 25074018
- Collins CB, Strassheim D, Aherne CM, Yeckes AR, Jedlicka P, de Zoeten EF. Targeted inhibition of heat shock protein 90 suppresses tumor necrosis factor-a and ameliorates murine intestinal inflammation. Inflamm Bowel Dis. 2014 Apr;20(4):685-94. PubMed PMID: 24552830
- Gustafson CE, Higbee D, Yeckes AR, Wilson CC, De Zoeten EF, Jedlicka P, Janoff EN. Limited expression of APRIL and its receptors prior to intestinal IgA plasma cell development during human infancy. Mucosal Immunol. 2014 May;7(3):467-77. PubMed PMID: 24045575
- Shin DS, Jordan A, Basu S, Thomas RM, Bandyopadhyay S, de Zoeten EF, Wells AD, Macian F. Regulatory T cells suppress CD4 T cells through NFAT-dependent transcriptional mechanisms. EMBO Rep. 2014 Sep;15(9):991-9. PubMed PMID: 25074018
- Collins CB, Aherne CM, Yeckes A, Pound K, Eltzschig HK, Jedlicka P, de Zoeten EF. Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function. Mucosal Immunol. 2013 Jan 16. [Epub ahead of print] PubMed PMID: 23321985
- Puthoor PR, de Zoeten EF. Pediatric Ulcerative Colitis: The Therapeutic Road to Infliximab. Biol Ther. 2013;3:1-14. PubMed PMID: 24392300
- Gustafson CE, Higbee D, Yeckes AR, Wilson CC, De Zoeten EF, Jedlicka P, Janoff EN. Limited expression of APRIL and its receptors prior to intestinal IgA plasma cell development during human infancy. Mucosal Immunol. 2013 Sep 18. [Epub ahead of print] PubMed PMID: 24045575
- de Zoeten EF, Pasternak BA, Mattei P, Kramer RE, Kader HA. Diagnosis and treatment of perianal Crohn disease: NASPGHAN clinical report and consensus statement. J Pediatr Gastroenterol Nutr. 2013 Sep;57(3):401-12. PubMed PMID: 23974063
- Collins CB, Aherne CM, Ehrentraut SF, Gerich ME, McNamee EN, McManus MC, Lebsack MD, Jedlicka P, Azam T, de Zoeten EF, Dinarello CA, Rivera-Nieves J. Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Inflamm Bowel Dis. 2013 Aug;19(9):1964-73. PubMed PMID: 23835442
- Furuta GT, Atkins D, Capocelli KE, de Zoeten EF, Fleischer D, Menard-Katcher C. Antitumor necrosis factor, infliximab, and adalimumab: use with caution in eosinophilic bowel disease. J Pediatr Gastroenterol Nutr. 2013 Oct;57(4):e25. PubMed PMID: 23820407
- de Zoeten EF, Pasternack BA, Mattei P, Kramerand RE, Kader HA. NASPGHAN clinical report and consensus statement: Diagnosis and Treatment of Perianal Crohns Disease. J Pediatr Gastroenterol Nutr. 2013 Jun 25. [Epub ahead of print] PubMed PMID: 23803958
- Denson LA, Long MD, McGovern DP, Kugathasan S, Wu GD, Young VB, Pizarro TT, de Zoeten EF, Stappenbeck TS, Plevy SE, Abraham C, Nusrat A, Jobin C, McCole DF, Siegel CA, Higgins PD, Herfarth HH, Hyams J, Sandborn WJ, Loftus EV Jr, Kappelman MD, Lewis JD, Parkos CA, Sartor RB, Challenges Workgroup. Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda. Inflamm Bowel Dis. 2013 Mar-Apr;19(4):677-82. PubMed PMID: 23448796
- Collins CB, Aherne CM, Yeckes A, Pound K, Eltzschig HK, Jedlicka P, de Zoeten EF. Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function. Mucosal Immunol. 2013 Sep;6(5):960-71. PubMed PMID: 23321985
- Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2784-93. PubMed PMID: 22988108
- Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE. IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. J Immunol. 2012 Aug 15;189(4):1792-9. PubMed PMID: 22786766
- Hunter A, Spechler PA, Cwanger A, Song Y, Zhang Z, Ying GS, Hunter AK, Dezoeten E, Dunaief JL. DNA methylation is associated with altered gene expression in AMD. Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2089-105. PubMed PMID: 22410570
Practice Locations
Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234
Hospital Affiliation
13123 East 16th Ave
Aurora, CO 80045
720-777-1234
Hospital Affiliation
- University of Colorado Hospital
- Children's Hospital Colorado
Specialty Information
Specialties
- Pediatrics, Board Certification (2004)
- Pediatric Gastroenterology, Board Certification (2007)
- Digestive System - Gastroenterology (Stomach, Bowel, General GI Problems)
- Digestive System - Therapeutic Endoscopy
- Digestive System - Inflammatory Bowel Disease (IBD): Crohn’s disease, ulcerative colitis, microscopic colitis
- Digestive System
Clinical Interests
My clinical interests include the care and treatment of patients with Inflammatory Bowel Diseases, Novel treatments for IBD, as well as Immunodeficiencies affecting the gastrointestinal system, and other issues involving the GI tract.
Care Philosophy
I take into account the entire child in developing a plan for patient with Inflammatory Bowel Disease. I work with Dieticians, Psychologists and Social Workers to develop a therapeutic plan. I strive to listen to patients concerns and thoughts and work with the patient and family to come to a mutually agreed upon therapy that I think will benefit my patients. I focus on evidence based medicine to guide these decisions.
My clinical interests include the care and treatment of patients with Inflammatory Bowel Diseases, Novel treatments for IBD, as well as Immunodeficiencies affecting the gastrointestinal system, and other issues involving the GI tract.
Care Philosophy
I take into account the entire child in developing a plan for patient with Inflammatory Bowel Disease. I work with Dieticians, Psychologists and Social Workers to develop a therapeutic plan. I strive to listen to patients concerns and thoughts and work with the patient and family to come to a mutually agreed upon therapy that I think will benefit my patients. I focus on evidence based medicine to guide these decisions.
Personal Interests
In my spare time I enjoy skiing, hiking, cooking and my children
In my spare time I enjoy skiing, hiking, cooking and my children
General Information
Medical Schools:
- MD, University of Illinois College of Medicine (2001)
Graduate Schools:
- PhD, University of Illinois At Chicago (2001)
Undergraduate Schools:
- BS, University of Wisconsin–Madison (WI) (1992)
Internships:
- University of Colorado (University Hospital) Program (2002)
Residency Programs:
- University of Colorado (University Hospital) Program, Pediatrics (2004)
Fellowships:
- University of Pennsylvania/Children's Hospital of Philadelphia Program, Pediatric Gastroenterology (2004)
Department: Pediatrics-Gastroenterology, Hepatology and Nutrition