Cara Mack, MD

Recognitions

• Phi Eta Sigma, Freshman Honor Society, Univ of WI Madison (1983)
  
• Diabetes Young Investigator Award, Loyola University Stritch School of Medicine (1989)
  research award
• Illinois Department of Public Health Scholarship, State of Illinois (1990)
  clinical scholarship
• Basil O'Connor Starter Scholar Research Award, March of Dimes Foundation (2005)
  
• Pediatric Research Abstract Award, American Association for the Study of Liver Disease (2005)
  
• Inductee, Best Doctors in America, Best Doctors in America Inc. (2010)
  

Research Interests

I am involved in many research projects with the overall theme of optimizing the lives of children with liver diseases. -I am investigating what causes the bile duct injury in biliary atresia. Furthermore, I am involved in a nationwide study to test different agents that may improve liver health in those with biliary atresia. -I am involved in a clinical research study investigating the use of a medicine to improve outcomes in sclerosing cholangitis.

Publications

• Feldman AG, Mack CL. Biliary atresia: cellular dynamics and immune dysregulation. Semin Pediatr Surg. 2012 Aug;21(3):192-200. PubMed PMID: 22800972
• Mack CL, Gonzalez-Peralta RP, Gupta N, Leung D, Narkewicz MR, Roberts EA, Rosenthal P, Schwarz KB, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents. J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):838-55. PubMed PMID: 22487950
• Tucker RM, Mack CL. Generation of a cholangiocyte-specific cDNA expression library for the identification of B and T cell autoantigens in murine biliary disease. Hepatol Res. 2012 May;42(5):502-7. PubMed PMID: 22236071
• Brindley SM, Lanham AM, Karrer FM, Tucker RM, Fontenot AP, Mack CL. Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. Hepatology. 2012 Apr;55(4):1130-8. PubMed PMID: 22105891
• Brumbaugh D, Mack C. Conjugated hyperbilirubinemia in children. Pediatr Rev 2012;33(7):291-302.
• Feldman AG, Tucker RM, Fenner EK, Pelanda R, Mack CL. B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia. PLoS One. 2013;8(8):e73644. PubMed PMID: 23991203
• Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, Bezerra JA, Karpen SJ, Kerkar N, Shneider BL, Turmelle YP, Whitington PF, Molleston JP, Murray KF, Ng VL, Romero R, Wang KS, Sokol RJ, Magee JC, Childhood Liver Disease Research and Education Network. Extrahepatic anomalies in infants with biliary atresia: results of a large prospective north american multicenter study. Hepatology. 2013 Nov;58(5):1724-31. PubMed PMID: 23703680
• Tucker RM, Feldman AG, Fenner EK, Mack CL. Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia. J Hepatol. 2013 Oct;59(4):790-6. PubMed PMID: 23685050
• Mack CL, Anderson KM, Aubrey MT, Rosenthal P, Sokol RJ, Freed BM. Lack of HLA predominance and HLA shared epitopes in biliary Atresia. Springerplus. 2013 Dec;2(1):42. PubMed PMID: 23505615
• Fenner E, Boguniewicz J, Tucker RM, Feldman A, Mack CL. High dose intravenous immunoglobulin abrogates biliary obstruction in a mouse model of biliary atresia. Pediatr Res 2014 Apr 11. Epub ahead of print. PMID: 24727948, PMCID: PMC4062601
• Feldman A, Mack CL. Biliary Atresia: Clinical Lessons Learned. J Pediatr Gastroenterol Nutr 2015; 61(2):167-175. PMID 25658057.
• Mack CL. What Causes Biliary Atresia? Unique Aspects of the Neonatal Immune System Provide Clues to Disease Pathogenesis. Cell Mol Gastroenterol Hepatol 2015;1(3):267-274. PMID: 26090510.
• 42. Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin V, Molleston JP, Neimark E, Ng VL, Karpen SJ. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), J Pediatr Gastroenterol Nutr 2015: accepted for publication October 2015.
• Sheiko MA, Giugliano S, Waasdorp-Hurtado C, MD, Mack CL, Narkewicz, M, Rosen HR, Golden L. CD4+ helper T Cell Activation in Children with Hepatitis C, Jrl Pediatr 2015: accepted for publication November 2015.
• Sundaram S, Mack CL. Abnormalities of Carbohydrate Metabolism and the Liver. Chpt. 73. In: Wylie and Hyams (eds.), Pediatric Gastrointestinal and Liver Disease, 5th Edition, Elsevier 2015.
• 45. Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM, Schwarz K, Whitington PF, Bezerra JA, Kerkar N, Haber B, Rosenthal P, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN;…Mack C…). Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia. J Pediatr. 2016;170:211-217. PMID:26725209
• 46. Sheiko MA, Golden-Mason L, Giugliano S, Waasdorp-Hurtado C, Mack CL, Narkewicz M, Rosen HR. CD4+ and CD8+ T Cell Activation in Children with Hepatitis C, J Pediatr 2016;170:142-48. PMID: 26743497.
• 47. Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin V, Molleston JP, Neimark E, Ng VL, Karpen SJ. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), J Pediatr Gastroenterol Nutr 2017;64(1):154-168. PMID: 27429428.
• 48. Sundaram SS, Mack CL, Feldman AG, Sokol RJ. Biliary Atresia: Indications and Timing of Liver Transplantation and Optimization of Pre-Transplant Care. Liver Transpl 2017;23(1):96-109.PMID: 27650268.
• 49. Sheiko MA, Sundaram SS, Capocelli KE, Zhaoxing P, McCoy AM, Mack CL. Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites. J Pediatr Gastroenterol Nutr 2016 Dec 15; accepted for publication.
• 50. Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL; The Childhood Liver Disease Research Network (ChiLDReN). Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology. 2016 Dec 27. Epub ahead of print. PMID: 28027587.
• 8. Molla-Hosseini D, Mack CL. Pediatric PSC. Chpt. 3. In: Forman L. (ed.) Primary Sclerosing Cholangitis, 1st Edition, Springer 2016.
• Kilgore A, Mack CL. Update on investigations pertaining to the pathogenesis of biliary atresia. Pediatr Surg Int. 2017 Dec;33(12):1233-1241. PubMed PMID: 29063959
• Mark JA, Mack CL, Marwan AI, Kramer RE. Use of Fully Covered Self-Expanding Metal Biliary Stents in Pediatrics: A Case Series. J Pediatr Gastroenterol Nutr. 2017 Aug 23. [Epub ahead of print] PubMed PMID: 28837510
• Sheiko MA, Sundaram SS, Capocelli KE, Pan Z, McCoy AM, Mack CL. Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites. J Pediatr Gastroenterol Nutr. 2017 Jul;65(1):80-85. PubMed PMID: 28272159
• Cotter J, Browne L, Capocelli K, McCoy A, Mack CL. Lack of correlation of liver tests with fibrosis stage at diagnosis in pediatric primary sclerosing cholangitis. J Pediatr Gastroenterol Nutr 2018;66(2):227-233. PMID: 29356767
• Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA,Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN…Mack CL…). Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver: Results from the ChiLDReN Study. J Pediatr. 2018;196:139-147. PMID: 29519540
• Bednarek J, Traxinger B, Brigham D, Roach J, Orlicky D, Wang D, Pelanda R, Mack CL. Cytokine-producing B cells promote immune-mediated bile duct injury in murine biliary atresia. Hepatology 2018;68(5):1890-1904. PMID: 29679373
• Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, Sokol RJ. Biliary atresia: Clinical and research challenges for the 21st century. Hepatology 2018. Epub ahead of print. PMID: 29604222
• Sundaram SS, Mack CL, Feldman AG, Sokol RJ. Biliary atresia: Indications and timing of liver transplantation and optimization of pretransplant care. Liver Transpl. 2017 Jan;23(1):96-109. PubMed PMID: 27650268
• Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Bezerra JA, Magee JC; ChiLDReN Network. Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial. J Pediatr. 2018;202:179-185. PMID: 30244988
• Kamath B, Mack CL. From hepatocyte to cholangiocyte: the remarkable potential of transdifferentiation to treat cholestatic diseases. Hepatology. 2018 Sep 4. [Epub ahead of print]. PMID: 30179266
• Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2017 Jan;64(1):154-168. PubMed PMID: 27429428
• Shneider BL, Spino C, Kamath BM, Magee JC, Bass LM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Murray KF, Loomes KM, Rosenthal P, Karpen SJ, Leung DH, Guthery SL, Thomas D, Sherker AH, Sokol RJ; Childhood Liver Disease Research Network. Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome. Hepatol Commun. 2018;2(10):1184-1198. PMID: 30288474
• Deneau MR, Mack CL, Abdou R, Amin M, Amir A, Auth M et al. GGT reduction is associated with favorable outcomes in pediatric PSC. Hepatol Commun 2018;2(11):1369-78.
• Deneau MR, El-Matary W, Valentino PL, Abdou R, Alqoaer K, Amin M, Amir AZ, Auth M, Bazerbachi F, Broderick A, Chan A, Cotter J, Doan S, El-Youssef M, Ferrari F, Furuya KN, Gottrand M, Gottrand F, Gupta N, Homan M, Kamath BM, Kim KM, Kolho KL, Konidari A, Koot B, Iorio R, Ledder O, Mack C, Martinez M, Miloh T, Mohan P, O'Cathain N, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Vos MB, Woynarowski M, Yap J, Jensen MK. The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration. Hepatology. 2017 Aug;66(2):518-527. PubMed PMID: 28390159
• Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider BL. Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology. 2017 May;65(5):1645-1654. PubMed PMID: 28027587
• Under revision: Mack CL, Spino C, Whitington PF, Bezerra JA, Moore J, Goodhue C, Ng V, Karpen SJ, Venkat V, Loomes K, Wang K, Sherker A, Magee J, Sokol RJ and the ChiLDReN Network. A Phase I/IIa trial of intravenous immunoglobulin therapy following portoenterostomy in infants with biliary atresia (PRIME study). Submitted to Journal of Pediatrics,
• Accepted for publication: Cotter J, Browne L, Capocelli K, McCoy A, Mack CL. Fibrosis in Pediatric Primary Sclerosing Cholangitis: Moderate Liver Fibrosis, Mild Biliary Strictures and Lack of Biomarker Correlation. J Pediatr Gastroenterol Nutr.
• Mack CL, Spino C, Alonso EA, Bezerra JA, Moore J, Goodhue C, Ng V, Karpen SJ, Venkat V, Loomes K, Wang K, Sherker A, Magee J, Sokol RJ and the ChiLDReN Network. A Phase I/IIa trial of intravenous immunoglobulin therapy following portoenterostomy in infants with biliary atresia (PRIME study). J Pediatr Gastroenterol Nutr 2018; in press.
• Kim S, Moore J, Alonso E, Bednarek J, Bezerra JA, Goodhue C, Karpen SJ, Loomes KM, Magee JC, Ng VL, Sherker AH, Smith C, Spino C, Venkat V, Wang K, Sokol RJ, Mack CL and the Childhood Liver Disease Research Network. Correlation of Immune Markers with Outcomes in Biliary Atresia Following Intravenous Immunoglobulin Therapy. Submitted to Hepatol Commun Nov. 30, 2018.
• Jaramillo C, Gilani A, Haag M, Donaldson N, Mack CL. Synovial Cell Sarcoma inn an Adolescent Liver Transplant Recipient. Submitted to ACG Case Reports Journal, Dec. 10, 2018.
• Taylor S, Assis D, Mack CL. B Cells in Liver Disease. Submitted to Semin Liv Dis, Dec. 15, 2018.
• Suchy FJ, Mack CL. Chpt. 62. Anatomy, Embryology, Developmental Anomalies and Pediatric Disorders of the Biliary Tract. In: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 11th edition, Elsevier 2018.
• Accepted for publication: Cotter J, Mack CL. Unique aspects of PSC in Children. Clinics in Liver Disease.
• Mack CL, Gourley G. Chpt 16. Jaundice. Wylie and Hams (eds.), Pediatric Gastrointestinal and Liver Disease, 6th Edition, Elsevier 2018.
• Under revision: Bednarek et al. B cells produce cytokines to promote T cell activation and bile duct injury independent of antigen presentation in murine biliary atresia. Submitted to Hepatology Dec 2017
• Boster J, Mack CL. Neonatal Cholestasis and Biliary Atresia. In: Encyclopedia of Gastroenterology, 2nd Edition.
• Submitted for Review to Clinical Gastro and Hepatol Dec 2017: Deneau M et al. Evaluation of gamma glutamyltransferase as a surrogate endpoint in pediatric primary sclerosing cholangitis.
• D.D. Black, C.L. Mack, N. Kerkar, et al. Initial results of the WUPPSC study- prospective multicenter withdrawal of UDCA in pediatric PSC. Poster presentation, DDW, 2018, Washington D.C.
• M. Deneau, … C.L. Mack, et al. Variability in Diagnostic and Therapeutic Strategies for Pediatric Primary Sclerosing Cholangitis between Centers in the Pediatric PSC Consortium, Poster presentation, AASLD, 2018, San Francisco, CA
• M. Deneau, …. C.L. Mack, et al. Clinical Outcomes of Oral Vancomycin Therapy for Children with Primary Sclerosing Cholangitis in the Pediatric PSC Consortium, Oral presentation, AASLD, 2018, San Francisco, CA
• M. Bannerman, C.L. Mack, et al. Inflammation Drives microRNA Expression to Limit Hepatocyte Bile Acid Synthesis and Transport in the Biliary Atresia Mouse Model, Poster presentation, *Poster of Distinction, AASLD, 2018, San Francisco, CA
• V. Venkat,… C.L. Mack, et al. Predictors of Outcome in Children with Biliary Atresia Surviving with Native Liver at Two Years of Age, Oral presentation, AASLD, 2018, San Francisco, CA
• 9 abstracts presented at local and national meetings
• D.D. Black, C.L. Mack, N. Kerkar, et al. Results of the WUPPSC study: prospective multicenter withdrawal of ursodeoxycholic acid in pediatric primary sclerosing cholangitis, Oral presentation, NASPGHAN, 2018, Hollywood, FL.
• Black DD, Mack C, Kerkar N, Miloh T, Sundaram SS, Anand R, Gupta A, Alonso E, Arnon R, Bulut P, Karpen S, Lin CH, Rosenthal P, Ryan M, Squires RH, Valentino P, Elsea SH, Shneider BL. A Prospective Trial of Withdrawal and Reinstitution of Ursodeoxycholic Acid in Pediatric Primary Sclerosing Cholangitis. Hepatol Commun. 2019 Nov;3(11):1482-1495. PubMed PMID: 31701072
• Deneau M, Valentino P, Mack C, Alqoaer K, Amin M, Amir A, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, El-Matary W, Ferrari F, Furuya K, Gottrand F, Gupta N, Homan M, Jensen MK, Kamath BM, Kim KM, Kolho KL, Koot BG, Iorio R, Martinez M, Miloh T, Mohan P, Palle S, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Woynarowski M, Guthery S. Assessing the Validity of Adult-Derived Prognostic Models for Primary Sclerosing Cholangitis Outcomes in Children. J Pediatr Gastroenterol Nutr. 2019 Oct 22. [Epub ahead of print] PubMed PMID: 31651664
• Jaramillo C, Gilani A, Haag M, Donaldson N, Mack C. Synovial Cell Sarcoma in an Adolescent Liver Transplant Recipient. ACG Case Rep J. 2019 May;6(5):e00091. PubMed PMID: 31616756
• Taylor SA, Assis DN, Mack CL. The Contribution of B Cells in Autoimmune Liver Diseases. Semin Liver Dis. 2019 Nov;39(4):422-431. PubMed PMID: 31226726
• Luo Y, Brigham D, Bednarek J, Torres R, Wang D, Ahmad S, Mack CL. Unique cholangiocyte-targeted IgM autoantibodies correlate with poor outcomes in biliary atresia. Hepatology 2020 Aug 7. Epub ahead of print. PMID: 32767570
• Azeltine MW, Chavez E, Nemec KM, Benarek JM, Asokan R, Balasubramaniyan N, Zgheib C, Mack CL, Roach JP. Inflammation Drives miRNAs to limit epatocyte bile acid transport in urine Bilibary atresia. Jrl Surg Res 2020;256:663-72. PMID: 32818799
• Deneau M, Valentino P, Mack C, Alqoaer K, Amin M, Amir A, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, El-Matary W, Ferrari F, Furuya K, Gottrand F, Gupta N, Homan M, Jensen MK, Kamath BM, Kim KM, Kolho KL, Koot BG, Iorio R, Martinez M, Miloh T, Mohan P, Palle S, Papadopoulou A, Ricciuto A, Saubermann L, Sathya P, Shteyer E, Smolka V, Tanaka A, Varier R, Venkat V, Vitola B, Woynarowski M, Guthery S. Assessing the Validity of Adult-derived Prognostic models for PSC outcomes in children. J Pediatr Gastroenterol Nutr. 2020;70(1):12-17. PMID: 31651664
• Kamath BM, Wen Y, Goodrich NP, Loomes KM, Romero R, Heubi JE, Leung DH, Spinner NB, Piccoli DA, Alonso EM, Guthery SL, Karpen SJ, Mack CL, Molleston JP, Murray KF, Rosenthal P, Squires JE, Teckman JH, Wang KS, Thompson RJ, Magee JC, Sokol RJ, the Childhood Liver Disease Research Network. Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multi-Centre Observational Study. Hepatol Commun. 2019, Nov. 27; in press.
• Kim S, Moore J, Alonso E, Bednarek J, Bezerra JA, Goodhue C, Karpen SJ, Loomes KM, Magee JC, Ng VL, Sherker AH, Smith C, Spino C, Venkat V, Wang K, Sokol RJ, Mack CL. Correlation of Immune Markers With Outcomes in Biliary Atresia Following Intravenous Immunoglobulin Therapy. Hepatol Commun. 2019 May;3(5):685-696. PubMed PMID: 31061956
• Kamath BM, Spino C, McLain R, Magee JC, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Alonso EM, Murray KF, Loomes KM, Jensen MK, Karpen SJ, Rosenthal P, Thomas D, Sokol RJ, Shneider BL. Unraveling the Relationship between Itching, Scratch Scales, and Biomarkers in Children with Alagille Syndrome. Hepatol Comm 2020;4(7):1012-1018. PMID: 32626833 / PMCID: PMC7327199
• El-Matary W, Guthery SL, Amir AZ, DiGuglielmo M, Draijer LG, Furuya KN, Gupta N, Hochberg JT, Horslen S, Kerkar N, Koot BG, Laborda TJ, Loomes KM, Mack C, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Moroz S, Ovchinsky N, Perito ER, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Soufi N, Valentino PL, Zizzo A, Deneau MR. Colorectal Dysplasia and Cancer in Pediatric-onset Ulcerative Colitis Associated with Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. 2020 Apr 29. Epub ahead of print. PMID: 32360820
• Deneau MR, Mack C, Perito ER, Ricciuto A, Valentino PL, Amin M, Amir AZ, Aumar M Auth M, Broderic A, et al. The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) index: a prognostic tool for children. Hepatology. 2020 May 28. Doi:10.1002/hep.31393. Epub ahead of print. PMID: 32464706
• Feldman AG, Parsons JA, Dutmer CM, Veerapandiyan A, Hafberg E, Maloney N, Mack CL. Subacute Liver Failure Following Gene Replacement Therapy for Spinal Muscular Atrophy Type I. Jrl Pediatr 2020, May 27. Epub ahead of print. DOI: https://doi.org/10.1016/j.jpeds.2020.05.044. PMID: 32473148
• Venkat V, Ng VL, Magee JC, Wen Y, Hawthorne K, Harpavat S, Molleston JP, Murray KF, Wang KS, Soufi N, Bass LM, Alonso EM, Bezerra JA, Jensen MK, Kamath BM, Loomes KM, Mack CL, Rosenthal P, Shneider BL, Squires RH, Sokol RJ, Karpen SJ, Childhood Liver Disease Research Network. Modeling outcomes in children with biliary atresia with native liver after 2 years of age. Hepatol Comm 2020 Oct 3, Epub ahead of print.
• Deneau MR, Mack C, Mogul D, Perito ER, Valentino PL, Amir AZ et al. Oral vancomycin, ursodeoxycholic acid or no therapy for pediatric primary sclerosing cholangitis: a matched analysis. Hepatology 2020 Sep 18. Online ahead of print. PMID: 32946600
• Kemme S, Stahl M, Brigham D, Lovell MA, Nakano T, Feldman AG, Mack C. Outcomes of severe seronegative hepatitis-associated aplastic anemia: a pediatric case series. J Pediatr Gastroenterol Nutr 2020 Sep 9. Online ahead of print. PMID 32925550
• Deneau M, Perito E, Ricciuto A, Gupta N, Kamath BM, Palle S, Vitola B, Smolka V, Ferrari F, Amir AZ, Miloh T, Papadopoulou A, Mohan P, Mack C, Kolho KL, Iorio R, El-Matary W, Venkat V, Chan A, Saubermann L, Valentino PL, Shah U, Miethke A, Lin H, Jensen MK. Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis: Predictors of Gamma Glutamyltransferase Normalization and Favorable Clinical Course. J Pediatr. 2019 Jun;209:92-96.e1. PubMed PMID: 30878206
• Feldman AG, Hsu EK, Mack CL. The Importance of Prioritizing Pre- and Post-Transplant Immunizations in An Era of Vaccine Refusal and Epidemic Outbreaks. Transplantation 2020;104(1):33-38. PMID: 31876696
• Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ. Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the Study of Liver Diseases. Hepatology 2020;72(2):671-722. PMID: 31863477
• Mack CL, Spino C, Alonso EM, Bezerra JA, Moore J, Goodhue C, Ng VL, Karpen SJ, Venkat V, Loomes KM, Wang K, Sherker AH, Magee JC, Sokol RJ. A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia. J Pediatr Gastroenterol Nutr. 2019 Apr;68(4):495-501. PubMed PMID: 30664564
• Inherited cholestatic diseases in the era of personalized medicine. Clin Liver Dis 2019, July 20; [Epub ahead of print]
• Vierling JM, Kerkar N, Czaja AJ, Mack CL, Adams D, Assis D, Manns M, Mayo M, Nayfeh T, Majzoub AMMM, Alzuabi MA, Ding J, Haffar S, Murad MH, Alsawas M. Immunosuppressive Treatment Regimens in Autoimmune Hepatitis: Systematic Reviews and Meta-Analyses Supporting AASLD Guidelines. Hepatology 2020;72(2):753-769. PMID: 32500593
• Goldberg A, Mack CL. Inherited cholestatic diseases in the era of personalized medicine. Clin Liver Dis 2020;15(3):105-109. PMID: 32257121
• Karpen SJ, Kelly D, Mack C, Stein P. Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders. Hepatol Int. 2020;14(5):677-89. PMID: 32653991
• Mack CL, Gourley G. Jaundice. Wylie and Hams (eds.), Chpt 16. In: Wylie and Hyams (eds.), Pediatric Gastrointestinal and Liver Disease, 6th Edition, Elsevier 2020.
• Sundaram S, Mack CL. Abnormalities of Carbohydrate Metabolism and the Liver. Chpt. 73. In: Wylie and Hyams (eds.), Pediatric Gastrointestinal and Liver Disease, 6th Edition, Elsevier 2020.
• Sokol RJ, Narkewicz MR, Mark JA, Mack CL, Feldman AG, Sundaram SS: Liver & Pancreas. In: Hay WW, Levin MJ, Deterding RR, Abzug MJ, (eds), Current Pediatric Diagnosis & Treatment, 25th edition McGraw-Hill Medical, NY NY, 2020.
• Kerkar N, Mack CL. Autoimmune hepatitis. In: Suchy FJ, Sokol RJ, Balistreri WF, Shneider B, Mack CL and Bezerra J (eds.), Liver Disease in Children, 5th Edition, Lippincott Williams & Wilkins, PA. 2020.
• Taylor S, Narkewicz M, Mack CL. Disorders of Iron Storage. In: Suchy FJ, Sokol RJ, Balistreri WF, Shneider B, Mack CL and Bezerra J (eds.), Liver Disease in Children, 5th Edition, Lippincott Williams & Wilkins, PA. 2020.
• Feldman AG, Hsu EK, Mack CL. The Importance of Prioritizing Pre- and Post-Transplant Immunizations in An Era of Vaccine Refusal and Epidemic Outbreaks. Transplantation 2019, Aug 9; [Epub ahead of print]
• *K. Loomes,… C. Mack… R. Thompson. Analysis from Phase 2 INDIGO study demonstrates transplant-free survival for pediatric patients with PFIC2. *Late-breaking abstract oral presentation, Digital International Liver Congress (EASL), August, 2020.
• Kamath BM, Wen Y, Goodrich NP, Loomes KM, Romero R, Heubi JE, Leung DH, Spinner NB, Piccoli DA, Alonso EM, Guthery SL, Karpen SJ, Mack CL, Molleston JP, Murray KF, Rosenthal P, Squires JE, Teckman JH, Wang KS, Thompson RJ, Magee JC, Sokol RJ, the Childhood Liver Disease Research Network. Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multi-Centre Observational Study. Hepatol Commun. 2019, Nov. 27; in press.
• Boster J, Mack CL. Neonatal Cholestasis and Biliary Atresia. In: Encyclopedia of Gastroenterology, 2nd Edition, 2019.
• Suchy FJ, Mack CL. Chpt. 62. Anatomy, Embryology, Developmental Anomalies and Pediatric Disorders of the Biliary Tract. In: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 11th edition, Elsevier 2019.
• J. Hochberg, …C. L. Mack…, M. Deneau. Pediatric PSC is Associated with Poor Outcomes in Racial/Ethnic Minorities. Poster Presentation, AASLD Virtual Meeting, 2020.
• *B.L. Shneider,…. C.L. Mack, …R.J. Sokol. Preliminary Analysis of ITCH and IMAGINE II- Outcome of Long Term Administration of Maralixibat in Children with Alagille Syndrome. *Oral Presentation, AASLD Virtual Meeting, 2020.
• 1. *R. Thompson, D. Kelly, S. Rajwal, A. Miethke, N. Soufi, C. Rivet, I. Jankowska, C. Mack, T. Jaeckin, R.H. Squires, K.M. Loomes. Growth analysis in children with PFIC treated with the ASBT inhibitor maralixibat. Oral presentation, EASL International Liver Congress, 2019, Vienna, Austria. 2. Y. Luo, D. Brigham, J. Bednarek, R. Torres, C. Mack. Cholangiocyte-specific IgM autoantibodies correlate with poor outcome in biliary atresia. *Poster presentation with Distinction, AASLD Annual Meeting, 2019, Boston, MA. 3. *M. Martinez,… C. Mack… M. Deneau. Primary sclerosing cholangitis immune reactivity pre-transplant is a predictor of recurrent disease after liver transplantation. *Oral presentation, AASLD Annual Meeting, 2019, Boston, MA. 4. *J. Bednarek, Y. Luo, R. Torres, C.L. Mack. Biliary atresia is associated with regulatory T cell abnormalities and Treg enhancer therapy attenuates disease in murine BA. *Oral presentation, AASLD Annual Meeting, 2019, Boston, MA. 5. *K. Loomes,… C. Mack… R. Thompson. Genotype and dose-dependent response to maralixibat in patients with bile salt export pump deficiency. *Oral presentation, AASLD Annual Meeting, 2019, Boston, MA.
• Mack C, Adams D, Assis D, Kerkar N, Manns M, Mayo M, Vierling J, Czaja A. DIAGNOSIS AND MANAGEMENT OF AUTOIMMUNE HEPATITIS IN ADULTS AND CHILDREN: 2019 PRACTICE GUIDANCE AND GUIDELINES FROM THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES. Hepatology 2019 Dec 17. In press. Article DOI: 10.1002/hep.31065
• 64. El-Matary W, Guthery SL, Amir AZ, DiGuglielmo M, Draijer LG, Furuya KN, Gupta N, Hochberg JT, Horslen S, Kerkar N, Koot BG, Laborda TJ, Loomes KM, Mack C, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Moroz S, Ovchinsky N, Perito ER, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Soufi N, Valentino PL, Zizzo A, Deneau MR. Colorectal Dysplasia and Cancer in Pediatric-onset Ulcerative Colitis Associated with Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. 2021;19(5):1067-1070. PMID: 32360820
• 65. Deneau MR, Mack C, Perito ER, Ricciuto A, Valentino PL, Amin M, Amir AZ, Aumar M Auth M, Broderic A, et al. The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) index: a prognostic tool for children. Hepatology 2021;73(3):1074-1087. PMID: 32464706
• 66. Luo Y, Brigham D, Bednarek J, Torres R, Wang D, Ahmad S, Mack CL. Unique cholangiocyte-targeted IgM autoantibodies correlate with poor outcomes in biliary atresia. Hepatology 2021;73(5):1855-1867. PMID: 32767570
• 67. Deneau MR, Mack C, Mogul D, Perito ER, Valentino PL, Amir AZ et al. Oral vancomycin, ursodeoxycholic acid or no therapy for pediatric primary sclerosing cholangitis: a matched analysis. Hepatology 2021;73(3):1061-1073. PMID: 32946600
• 68. Kemme S, Stahl M, Brigham D, Lovell MA, Nakano T, Feldman AG, Mack C. Outcomes of severe seronegative hepatitis-associated aplastic anemia: a pediatric case series. J Pediatr Gastroenterol Nutr 2021;72(2):194-201. PMID 32925550
• 69. Kemme S, Feldman AG, Mack C. Severe Seronegative Hepatitis-Associated Aplastic Anemia: Looking for the Best Treatment. J Pediatr Gastroenterol Nutr. 2021;73(2):e48. PMID: 34016886
• 70. Martinez M, Perito ER, Valentino P, Mack CL, Aumar M, Broderick A, Draijer LG, Fagundes EDT, Furuya KN, Gupta N, Horslen S, Jonas MM, Kamath BM, Kerkar N, Kim KM, Kolho KL, Koot BG, Laborda TJ, Lee CK, Loomes KM, Miloh T, Mogul D, Mohammed S, Ovchinsky N, Rao G, Ricciuto A, Schwarz KB, Smolka V, Tanaka A, Tessier MEM, Venkat VL, Vitola BE, Woynarowski M, Zerofsky M, Deneau MR. Recurrence of primary sclerosing cholangitis after liver transplant in children: an international observational study. Hepatology 2021;74(4):2047-2057. PMID: 34008252
• 91. Kemme S, Mack CL. Pediatric Autoimmune Liver Diseases: Autoimmune Hepatitis & Primary Sclerosing Cholangitis. Pediatr Clin North Amer. 2021;68(6):1293-1307. PMID: 34736590
• 92. Corrado M, Mack CL. Diagnostic Tools for Early Detection of Biliary Atresia- is a Newborn Screen Attainable? Clin Liv Disease. Accepted for publication Sept 9, 2021.
• 93. Boster J, Feldman A, Mack CL, Sokol RJ, Sundaram SS. Malnutrition in biliary atresia: Assessment, management and outcomes. Liv Transpl. 2021 Oct 20. Online ahead of print. DOI:10.002/lt.26339. PMID: 34669243

Professional Memberships

• American Association for the Study of Liver Disease, Member
• North American Society for Pediatric Gastroenterology, Hepatology and Nutrition , Member
• Society For Pediatric Research (SPR), Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• Children's Hospital Colorado

Specialty Information

Specialties

• Pediatric Gastroenterology, Board Certification (2005)
• Pediatrics, Board Certification (2002)
• Pediatric Transplant Hepatology, Board Certification (2006)

Conditions & Treatments

• Digestive System
• Digestive System - Gastroenterology (Stomach, Bowel, General GI Problems)
• Digestive System - Hepatology (Liver Disorders)
• Digestive System - Irritable Bowel Syndrome (IBS)
• Digestive System - Surgical Endoscopy
• Digestive System - Therapeutic Endoscopy