Associate Research Professor
(2002)
School of Medicine,
Neurosurgery
Mechanisms of neuron death in multiple sclerosis; Blood biomarkers for multiple sclerosis; Extracellular vesicles in CNS disorders; Phage-display.
Publications
Zhou W, Graner M, Paucek P, Beseler C, Boisen M, Bubak A, Asturias F, George W, Graner A, Ormond D, Vollmer T, Alvarez E, Yu X. Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis. Cell Death Dis. 2023 Apr 8;14(4):254. PubMed PMID: 37031195
Kowalski RG, Ledreux A, Violette JE, Neumann RT, Ornelas D, Yu X, Griffiths SG, Lewis S, Nash P, Monte AA, Coughlan CM, Deighan C, Grotta JC, Jones WJ, Graner MW. Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit. Stroke. 2023 Feb 2. [Epub ahead of print] PubMed PMID: 36727508
Kennedy PGE, Graner MW, Fringuello A, Zhou W, Pointon T, Alquatli K, Bisel S, Langford D, Yu X. Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders. J Neuroimmune Pharmacol. 2022 Dec;17(3-4):526-537. PubMed PMID: 34989971
Zhou W, Craft J, Ojemann A, Bergen L, Graner A, Gonzales A, He Q, Kopper T, Smith M, Graner MW, Yu X. Glioblastoma Extracellular Vesicle-Specific Peptides Inhibit EV-Induced Neuronal Cytotoxicity. Int J Mol Sci. 2022 Jun 28;23(13). PubMed PMID: 35806205
Kennedy PGE, George W, Yu X. The Possible Role of Neural Cell Apoptosis in Multiple Sclerosis. Int J Mol Sci. 2022 Jul 8;23(14). PubMed PMID: 35886931
Zhou W, Lovasz D, Zizzo Z, He Q, Coughlan C, Kowalski RG, Kennedy PGE, Graner AN, Lillehei KO, Ormond DR, Youssef AS, Graner MW, Yu X. Phenotype and Neuronal Cytotoxic Function of Glioblastoma Extracellular Vesicles. Biomedicines. 2022 Oct 27;10(11). PubMed PMID: 36359238
Kennedy, PGE, Graner, M., Li, X., Pointon, T., Dennison, K., Im, G., Curley, T., Tanimoto, K., Frank, L., Vollmer, T., Yu, X. Aberrant Immunoglobulin G glycosylation in Multiple Sclerosis. Journal of Neuroimmune Pharmacology. 2021.
Anthony Fringuello, Philip Tatman, Tadeusz H Wroblewski, John A Thompson, Xiaoli Yu, Kevin O Lillehei, Robert G Kowalski, Michael William Graner. Cytokine Laden Extracellular Vesicles Predict Patient Prognosis After Cerebrovascular Accident. International Journal of Molecular Sciences. 2021.
Yu, X., Zizzo, Z., Kennedy, PGE. An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis. Multiple Sclerosis and Related Disorders. 2021.