Kristen Nadeau, MD, MS
Professor, Pediatrics-Endocrinology

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Medical School:
  • MD, University of Wisconsin School of Medicine and Public Health (1998)
Residency:
  • Oregon Health & Science University, Pediatrics (2001)
Fellowships:
  • University of Colorado, Pediatric Endocrinology (2004)
Languages: English
Department: Pediatrics-Endocrinology

Professional Titles

  • Professor of Pediatrics

Recognition & Awards

  • Mayo Soley Award for Research and Mentoring, Western Society for Clinical Investigation (WSCI) (2019)
  • Medical School Alumni Early Career Award, University of Wisconsin Medical School (2019)
  • Outstanding Mentor Award, University of Colorado (2018)
  • Mid-Career Research Award, NIH Nutrition Obesity Research Center (NORC) (2017)

Teaching

  • Director, CU-SOM Longitudinal Mentored Scholarly Activity (2016)
    School of Medicine, Gme/Cme
    Research Mentoring
  • Co-Director, Clinical Sciences CLSC 6300/7300 (2018)
    Graduate School, Other
    Scientific Protocol Design

Publications

  • Kahn SE, Anderson CAM, Buse JB, Selvin E, Angell SY, Aroda VR, Cheng AYY, Danne T, Echouffo-Tcheugui JB, Fitzpatrick SL, Gadgil MD, Gastaldelli A, Gloyn AL, Green JB, Jastreboff AM, Kanaya AM, Kandula NR, Kovesdy CP, Laiteerapong N, Nadeau KJ, Pettus J, Pop-Busui R, Posey JE, Powe CE, Rebholz CM, Rickels MR, Sattar N, Shaw JE, Sims EK, Utzschneider KM, Vella A, Zhang C. Reflecting on a Year at the Helm of Diabetes Care. Diabetes Care. 2024 Jan 1;47(1):4-6. PubMed PMID: 38117988
  • Kahn SE, Anderson CAM, Buse JB, Selvin E, Angell SY, Aroda VR, Castle JR, Cheng AYY, Danne T, Echouffo-Tcheugui JB, Florez JC, Gadgil MD, Gastaldelli A, Green JB, Jastreboff AM, Kanaya AM, Kandula NR, Kovesdy CP, Laiteerapong N, Nadeau KJ, Pop-Busui R, Powe CE, Rebholz CM, Rickels MR, Sattar N, Shaw JE, Sims EK, Utzschneider KM, Vella A, Zhang C. "The Times They Are A-Changin'" at Diabetes Care. Diabetes Care. 2023 Jan 1;46(1):3-5. PubMed PMID: 36548704
  • Schäfer M, Browne LP, Truong U, Bjornstad P, Tell S, Snell-Bergeon J, Baumgartner A, Hunter KS, Reusch JEB, Barker AJ, Nadeau KJ, Schauer IE. Bromocriptine Improves Central Aortic Stiffness in Adolescents With Type 1 Diabetes: Arterial Health Results From the BCQR-T1D Study. Hypertension. 2023 Feb;80(2):482-491. PubMed PMID: 36472197
  • Vigers T, Vinovskis C, Li LP, Prasad P, Heerspink H, D'Alessandro A, Reisz JA, Piani F, Cherney DZ, van Raalte DH, Nadeau KJ, Pavkov ME, Nelson RG, Pyle L, Bjornstad P. Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes. Pediatr Nephrol. 2023 Jan;38(1):193-202. PubMed PMID: 35507146
  • Bjornstad P, Choi YJ, Platnick C, Gross S, Narongkiatikhun P, Melena I, Remmers L, Baca M, Schutte G, Dobbs T, Vigers T, Pyle L, Driscoll L, Tommerdahl K, Kendrick J, Looker HC, Dart A, Cherney D, van Raalte DH, Srivastava A, Li L, Prasad P, Saulnier P, Nelson RG, Johnson RJ, Nadeau KJ. Insulin Secretion, Sensitivity, and Kidney Function in Young Individuals With Type 2 Diabetes. Diabetes Care. 2023 Dec 28. [Epub ahead of print] PubMed PMID: 38153805
  • Leslie RD, Ma RCW, Franks PW, Nadeau KJ, Pearson ER, Redondo MJ. Understanding diabetes heterogeneity: key steps towards precision medicine in diabetes. Lancet Diabetes Endocrinol. 2023 Nov;11(11):848-860. PubMed PMID: 37804855
  • Abushamat LA, Enge D, Fujiwara T, Schäfer M, Clark EW, Englund EK, Scalzo RL, Johnston A, Rafferty D, Schauer IE, Whipple MO, Hunter K, Huebschmann AG, Nadeau KJ, Jarvis K, Barker AJ, Regensteiner JG, Reusch JEB. Obesity dominates early effects on cardiac structure and arterial stiffness in people with type 2 diabetes. J Hypertens. 2023 Nov 1;41(11):1775-1784. PubMed PMID: 37589719
  • Moore KR, Stotz SA, Terry MA, Seely EW, Gonzales K, Marshall G, Nadeau KJ, Akers A, Garcia-Reyes Y, Charron-Prochownik D. Respecting tribal voices in the development of a gestational diabetes risk reduction preconception counseling program for American Indian/Alaska Native adolescent females: a qualitative study. BMC Pregnancy Childbirth. 2023 Aug 1;23(1):552. PubMed PMID: 37528363
  • Ismail HM, Barua S, Wang J, Sabharwal A, Libman I, Bacha F, Nadeau KJ, Tosur M, Redondo MJ. Baseline leptin predicts response to metformin in adolescents with type 1 diabetes and increased body mass index. Diabetes Obes Metab. 2023 Nov;25(11):3420-3423. PubMed PMID: 37485878
  • Finn E, Severn C, Pyle L, Garrish J, Vigers T, Behn CGD, Zeitler PS, Sagel SD, Nadeau KJ, Chan CL. Hypoglycemia in children and young adults with cystic fibrosis during oral glucose tolerance testing vs. continuous glucose monitoring. Pediatr Pulmonol. 2023 Sep;58(9):2495-2504. PubMed PMID: 37350354
  • Charron-Prochownik D, Moore KR, Stotz S, Akers A, Beirne S, Brega AG, Chalmers L, Fischl A, Garrow H, Gonzales K, Nadeau KJ, O'Banion N, Powell J, Seely E, Powell B, Abujaradeh H, Sereika SM. Comparing American Indian/Alaska Native Adolescent Daughters' and Their Mothers' Awareness, Knowledge, Attitudes, and Behaviors Regarding Risk for Gestational Diabetes: Implications for Mother-Daughter Communication on Reproductive Health. Sci Diabetes Self Manag Care. 2023 Aug;49(4):267-280. PubMed PMID: 37332238
  • Gutierrez-Colina AM, Bristol M, Clark ELM, Sanchez N, Gulley LD, Ruzicka E, Handing EP, Kinsella E, Kutchman E, Witten M, Clementi MA, Thompson T, Pyle L, Aichele S, Goldschmidt AB, Belcher B, Nadeau KJ, Kelsey MM, Shomaker LB. Cognitive-behavioral therapy and exercise training in adolescent females with elevated depression symptoms and at-risk for type 2 diabetes: Protocol for a randomized controlled trial. Contemp Clin Trials. 2023 May;128:107150. PubMed PMID: 36918091
  • Pauley ME, Vinovskis C, MacDonald A, Baca M, Pyle L, Wadwa RP, Fornoni A, Nadeau KJ, Pavkov M, Nelson RG, Gordin D, de Boer IH, Tommerdahl KL, Bjornstad P. Triglyceride content of lipoprotein subclasses and kidney hemodynamic function and injury in adolescents with type 1 diabetes. J Diabetes Complications. 2023 Feb;37(2):108384. PubMed PMID: 36623423
  • Kahn SE, Anderson CAM, Buse JB, Selvin E, Angell SY, Aroda VR, Castle JR, Cheng AYY, Danne T, Echouffo-Tcheugui JB, Florez JC, Gadgil MD, Gastaldelli A, Green JB, Jastreboff AM, Kanaya AM, Kandula NR, Kovesdy CP, Laiteerapong N, Nadeau KJ, Pop-Busui R, Powe CE, Rebholz CM, Rickels MR, Sattar N, Shaw JE, Sims EK, Utzschneider KM, Vella A, Zhang C. "The Times They Are A-Changin'" at Diabetes Care. Diabetes Care. 2023 Jan 1;46(1):3-5. PubMed PMID: 36548704
  • Schäfer M, Browne LP, Truong U, Bjornstad P, Tell S, Snell-Bergeon J, Baumgartner A, Hunter KS, Reusch JEB, Barker AJ, Nadeau KJ, Schauer IE. Bromocriptine Improves Central Aortic Stiffness in Adolescents With Type 1 Diabetes: Arterial Health Results From the BCQR-T1D Study. Hypertension. 2023 Feb;80(2):482-491. PubMed PMID: 36472197
  • Bjornstad P, Chao LC, Cree-Green M, Dart AB, King M, Looker HC, Magliano DJ, Nadeau KJ, Pinhas-Hamiel O, Shah AS, van Raalte DH, Pavkov ME, Nelson RG. Youth-onset type 2 diabetes mellitus: an urgent challenge. Nat Rev Nephrol. 2023 Mar;19(3):168-184. PubMed PMID: 36316388
  • Vigers T, Vinovskis C, Li LP, Prasad P, Heerspink H, D'Alessandro A, Reisz JA, Piani F, Cherney DZ, van Raalte DH, Nadeau KJ, Pavkov ME, Nelson RG, Pyle L, Bjornstad P. Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes. Pediatr Nephrol. 2023 Jan;38(1):193-202. PubMed PMID: 35507146
  • Shah AS, Nadeau KJ, Dabelea D, Redondo MJ. Spectrum of Phenotypes and Causes of Type 2 Diabetes in Children. Annu Rev Med. 2022 Jan 27;73:501-515. PubMed PMID: 35084995
  • Ware MA, Kaar JL, Diniz Behn C, Bartlette K, Carreau AM, Lopez-Paniagua D, Scherzinger A, Xie D, Rahat H, Garcia-Reyes Y, Nadeau KJ, Cree-Green M. Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity. Obesity (Silver Spring). 2022 Jan;30(1):191-200. PubMed PMID: 34932884
  • Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND, Rosenblum N, Cefalu W, Andersen DK, Arreaza-Rubín G, Dhara C, James SP, Makarchuk MJ, Pin CL, Sato S, Verchere B, Woo M, Powers A, Estall J, Hoesli C, Millman J, Linnemann A, Johnson J, Pin CL, Hawkins M, Woo M, Gloyn A, Cefalu W, Rosenblum N, Huising MO, Benninger RKP, Almaça J, Hull-Meichle RL, MacDonald P, Lynn F, Melero-Martin J, Yoshihara E, Stabler C, Sander M, Evans-Molina C, Engin F, Thompson P, Shalev A, Redondo MJ, Nadeau K, Bellin M, Udler MS, Dennis J, Dash S, Zhou W, Snyder M, Booth G, Butte A, Florez J. Heterogeneity of Diabetes: ß-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes Care. 2022 Jan 1;45(1):3-22. PubMed PMID: 34782355
  • Chan CL, Pyle L, Vigers T, Zeitler PS, Nadeau KJ. The Relationship Between Continuous Glucose Monitoring and OGTT in Youth and Young Adults With Cystic Fibrosis. J Clin Endocrinol Metab. 2022 Jan 18;107(2):e548-e560. PubMed PMID: 34537845
  • Pauley ME, Vinovskis C, MacDonald A, Baca M, Pyle L, Wadwa RP, Fornoni A, Nadeau KJ, Pavkov M, Nelson RG, Gordin D, de Boer IH, Tommerdahl KL, Bjornstad P. Triglyceride content of lipoprotein subclasses and kidney hemodynamic function and injury in adolescents with type 1 diabetes. J Diabetes Complications. 2022 Dec 13;37(2):108384. [Epub ahead of print] PubMed PMID: 36623423
  • Rynders CA, Bowen AE, Cooper E, Brinton JT, Higgins J, Nadeau KJ, Wright KP Jr, Simon SL. A Naturalistic Actigraphic Assessment of Changes in Adolescent Sleep, Light Exposure, and Activity Before and During COVID-19. J Biol Rhythms. 2022 Dec;37(6):690-699. PubMed PMID: 36124632
  • Shah AS, Nadeau KJ, Kelsey MM. Broader Screening for Youth-Onset Type 2 Diabetes-We Just Are Not There Yet. JAMA Netw Open. 2022 Sep 1;5(9):e2220540. PubMed PMID: 36098974
  • Whipple MO, Pinto AJ, Abushamat LA, Bergouignan A, Chapman K, Huebschmann AG, Masters KS, Nadeau KJ, Scalzo RL, Schauer IE, Rafferty D, Reusch JEB, Regensteiner JG. Sex Differences in Physical Activity Among Individuals With Type 2 Diabetes Across the Life Span: A Systematic Review and Meta-analysis. Diabetes Care. 2022 Sep 1;45(9):2163-2177. PubMed PMID: 36044665
  • Hampton GS, Bartlette K, Nadeau KJ, Cree-Green M, Diniz Behn C. Mathematical modeling reveals differential dynamics of insulin action models on glycerol and glucose in adolescent girls with obesity. Front Physiol. 2022;13:895118. PubMed PMID: 35991189
  • Utzschneider KM, Ehrmann DA, Arslanian SA, Barengolts E, Buchanan TA, Caprio S, Edelstein SL, Hannon TS, Kahn SE, Kozedub A, Mather KJ, Nadeau KJ, Sam S, Tripputi M, Xiang AH, El Ghormli L. Weight loss and ß-cell responses following gastric banding or pharmacotherapy in adults with impaired glucose tolerance or type 2 diabetes: a randomized trial. Obesity (Silver Spring). 2022 Aug;30(8):1579-1588. PubMed PMID: 35894078
  • Tell SS, Schafer M, Vigers T, Baumgartner AD, Lyon E, Gross S, Polsky S, Snell-Bergeon JK, Schauer IE, Nadeau KJ. Bromocriptine quick-release as adjunct therapy in youth and adults with type 1 diabetes: A randomized, placebo-controlled crossover study. Diabetes Obes Metab. 2022 Nov;24(11):2148-2158. PubMed PMID: 35712800
  • Taylor AE, Ware MA, Breslow E, Pyle L, Severn C, Nadeau KJ, Chan CL, Kelsey MM, Cree-Green M. 11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome. J Endocr Soc. 2022 Jul 1;6(7):bvac037. PubMed PMID: 35611324
  • Kelsey MM, Zeitler PS, Nadeau KJ, Shah AS. Type 2 diabetes in youth: Rationale for use of off-label antidiabetic agents. Pediatr Diabetes. 2022 Sep;23(6):615-619. PubMed PMID: 35524343
  • Melena I, Piani F, Tommerdahl KL, Severn C, Chung LT, MacDonald A, Vinovskis C, Cherney D, Pyle L, Roncal-Jimenez CA, Lanaspa MA, Rewers A, van Raalte DH, Cara-Fuentes G, Parikh CR, Nelson RG, Pavkov ME, Nadeau KJ, Johnson RJ, Bjornstad P. Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: Results from the diabetic kidney alarm (DKA) study. J Diabetes Complications. 2022 Jun;36(6):108203. PubMed PMID: 35523653
  • Johnson MJ, Tommerdahl KL, Vinovskis C, Waikar S, Reinicke T, Parikh CR, Obeid W, Nelson RG, van Raalte DH, Pyle L, Nadeau KJ, Bjornstad P. Relationship between biomarkers of tubular injury and intrarenal hemodynamic dysfunction in youth with type 1 diabetes. Pediatr Nephrol. 2022 Dec;37(12):3085-3092. PubMed PMID: 35286453
  • Shah AS, Gidding SS, El Ghormli L, Tryggestad JB, Nadeau KJ, Bacha F, Levitt Katz LE, Willi SM, Lima J, Urbina EM. Relationship between Arterial Stiffness and Subsequent Cardiac Structure and Function in Young Adults with Youth-Onset Type 2 Diabetes: Results from the TODAY Study. J Am Soc Echocardiogr. 2022 Jun;35(6):620-628.e4. PubMed PMID: 35149207
  • Shah RD, Braffett BH, Tryggestad JB, Hughan KS, Dhaliwal R, Nadeau KJ, Levitt Katz LE, Gidding SS. Cardiovascular risk factor progression in adolescents and young adults with youth-onset type 2 diabetes. J Diabetes Complications. 2022 Mar;36(3):108123. PubMed PMID: 35123868
  • Shah AS, Nadeau KJ, Dabelea D, Redondo MJ. Spectrum of Phenotypes and Causes of Type 2 Diabetes in Children. Annu Rev Med. 2022 Jan 27;73:501-515. PubMed PMID: 35084995
  • Ware MA, Kaar JL, Diniz Behn C, Bartlette K, Carreau AM, Lopez-Paniagua D, Scherzinger A, Xie D, Rahat H, Garcia-Reyes Y, Nadeau KJ, Cree-Green M. Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity. Obesity (Silver Spring). 2022 Jan;30(1):191-200. PubMed PMID: 34932884
  • Chan CL, Pyle L, Vigers T, Zeitler PS, Nadeau KJ. The Relationship Between Continuous Glucose Monitoring and OGTT in Youth and Young Adults With Cystic Fibrosis. J Clin Endocrinol Metab. 2022 Jan 18;107(2):e548-e560. PubMed PMID: 34537845
  • Mokhlesi B, Tjaden AH, Temple KA, Edelstein SL, Sam S, Nadeau KJ, Hannon TS, Manchanda S, Mather KJ, Kahn SE, Ehrmann DA, Van Cauter E. Obstructive Sleep Apnea, Glucose Tolerance, and ß-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2021 Feb 5. [Epub ahead of print] PubMed PMID: 33547205
  • Bartlette K, Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Pyle L, Nadeau KJ, Cree-Green M, Diniz Behn C. Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration. Metabol Open. 2021 Mar;9:100078. PubMed PMID: 33511337
  • Jobira B, Frank DN, Silveira LJ, Pyle L, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome. PLoS One. 2021;16(1):e0245219. PubMed PMID: 33465100
  • Simon SL, Higgins J, Melanson E, Wright KP Jr, Nadeau KJ. A Model of Adolescent Sleep Health and Risk for Type 2 Diabetes. Curr Diab Rep. 2021 Jan 15;21(2):4. PubMed PMID: 33449241
  • Arslanian SA, El Ghormli L, Young Kim J, Tjaden AH, Barengolts E, Caprio S, Hannon TS, Mather KJ, Nadeau KJ, Utzschneider KM, Kahn SE. OGTT Glucose Response Curves, Insulin Sensitivity, and ß-Cell Function in RISE: Comparison Between Youth and Adults at Randomization and in Response to Interventions to Preserve ß-Cell Function. Diabetes Care. 2021 Jan 12. [Epub ahead of print] PubMed PMID: 33436401
  • Tommerdahl KL, Baumgartner K, Schäfer M, Bjornstad P, Melena I, Hegemann S, Baumgartner AD, Pyle L, Cree-Green M, Truong U, Browne L, Regensteiner JG, Reusch JEB, Nadeau KJ. Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes. Diabetes Care. 2021 Jan 5. [Epub ahead of print] PubMed PMID: 33402367
  • Ryder JR, Xu P, Nadeau KJ, Kelsey MM, Xie C, Jenkins T, Inge TH, Bjornstad P. Effect of surgical versus medical therapy on estimated cardiovascular event risk among adolescents with type 2 diabetes and severe obesity. Surg Obes Relat Dis. 2021 Jan;17(1):23-33. PubMed PMID: 33071178
  • Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND, Rosenblum N, Cefalu W, Andersen DK, Arreaza-Rubín G, Dhara C, James SP, Makarchuk MJ, Pin CL, Sato S, Verchere B, Woo M, Powers A, Estall J, Hoesli C, Millman J, Linnemann A, Johnson J, Pin CL, Hawkins M, Woo M, Gloyn A, Cefalu W, Rosenblum N, Huising MO, Benninger RKP, Almaça J, Hull-Meichle RL, MacDonald P, Lynn F, Melero-Martin J, Yoshihara E, Stabler C, Sander M, Evans-Molina C, Engin F, Thompson P, Shalev A, Redondo MJ, Nadeau K, Bellin M, Udler MS, Dennis J, Dash S, Zhou W, Snyder M, Booth G, Butte A, Florez J. Heterogeneity of Diabetes: ß-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes. 2021 Nov 13. [Epub ahead of print] PubMed PMID: 34957490
  • Tommerdahl KL, Nadeau KJ, Bjornstad P. Mechanisms of Cardiorenal Protection of Glucagon-Like Peptide-1 Receptor Agonists. Adv Chronic Kidney Dis. 2021 Jul;28(4):337-346. PubMed PMID: 34922690
  • Piani F, Melena I, Severn C, Chung LT, Vinovskis C, Cherney D, Pyle L, Roncal-Jimenez CA, Lanaspa MA, Rewers A, van Raalte DH, Obeid W, Parikh C, Nelson RG, Pavkov ME, Nadeau KJ, Johnson RJ, Bjornstad P. Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study. Pediatr Diabetes. 2021 Nov;22(7):1031-1039. PubMed PMID: 34435718
  • Shah AS, Helmrath MA, Inge TH, Xanthakos SA, Kelsey MM, Jenkins T, Trout AT, Browne L, Nadeau KJ. Study protocol: a prospective controlled clinical trial to assess surgical or medical treatment for paediatric type 2 diabetes (ST(2)OMP). BMJ Open. 2021 Aug 13;11(8):e047766. PubMed PMID: 34389568
  • Gourgari E, Nadeau KJ, Pyle L, Playford MP, Ma J, Mehta NN, Remaley AT, Gordon SM. Effect of metformin on the high-density lipoprotein proteome in youth with type 1 diabetes. Endocrinol Diabetes Metab. 2021 Jul;4(3):e00261. PubMed PMID: 34277985
  • Utzschneider KM, Tripputi MT, Kozedub A, Barengolts E, Caprio S, Cree-Green M, Edelstein SL, El Ghormli L, Hannon TS, Mather KJ, Palmer J, Nadeau KJ. Differential loss of ß-cell function in youth vs. adults following treatment withdrawal in the Restoring Insulin Secretion (RISE) study. Diabetes Res Clin Pract. 2021 Aug;178:108948. PubMed PMID: 34274407
  • Kahn SE, Edelstein SL, Arslanian SA, Barengolts E, Caprio S, Ehrmann DA, Hannon TS, Marcovina S, Mather KJ, Nadeau KJ, Utzschneider KM, Xiang AH, Buchanan TA. Effect of Medical and Surgical Interventions on a-Cell Function in Dysglycemic Youth and Adults in the RISE Study. Diabetes Care. 2021 Sep;44(9):1948-1960. PubMed PMID: 34135015
  • Sam S, Edelstein SL, Arslanian SA, Barengolts E, Buchanan TA, Caprio S, Ehrmann DA, Hannon TS, Tjaden AH, Kahn SE, Mather KJ, Tripputi M, Utzschneider KM, Xiang AH, Nadeau KJ. Baseline Predictors of Glycemic Worsening in Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2021 Sep;44(9):1938-1947. PubMed PMID: 34131048
  • Kahn SE, Mather KJ, Arslanian SA, Barengolts E, Buchanan TA, Caprio S, Ehrmann DA, Hannon TS, Marcovina S, Nadeau KJ, Utzschneider KM, Xiang AH, Edelstein SL. Hyperglucagonemia Does Not Explain the ß-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study. Diabetes Care. 2021 Sep;44(9):1961-1969. PubMed PMID: 34131047
  • Brooks-Worrell BM, Tjaden AH, Edelstein SL, Palomino B, Utzschneider KM, Arslanian S, Mather KJ, Buchanan TA, Nadeau KJ, Atkinson K, Barengolts E, Kahn SE, Palmer JP. Islet Autoimmunity in Adults With Impaired Glucose Tolerance and Recently Diagnosed, Treatment Naïve Type 2 Diabetes in the Restoring Insulin SEcretion (RISE) Study. Front Immunol. 2021;12:640251. PubMed PMID: 33981301
  • Nokoff NJ, Scarbro SL, Moreau KL, Zeitler P, Nadeau KJ, Reirden D, Juarez-Colunga E, Kelsey MM. Body Composition and Markers of Cardiometabolic Health in Transgender Youth on Gonadotropin-Releasing Hormone Agonists. Transgend Health. 2021 Apr;6(2):111-119. PubMed PMID: 33937527
  • Gallardi D, Xue X, Mercier E, Mills T, Lefebvre F, Rise ML, Murray HM. RNA-seq analysis of the mantle transcriptome from Mytilus edulis during a seasonal spawning event in deep and shallow water culture sites on the northeast coast of Newfoundland, Canada. Mar Genomics. 2021 Dec;60:100865. PubMed PMID: 33933383
  • Hudnut-Beumler J, Kaar JL, Taylor A, Kelsey MM, Nadeau KJ, Zeitler P, Snell-Bergeon J, Pyle L, Cree-Green M. Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity. Pediatr Diabetes. 2021 Aug;22(5):699-706. PubMed PMID: 33870630
  • Kelsey MM, Hilkin A, Pyle L, Severn C, Utzschneider K, Van Pelt RE, Zeitler PS, Nadeau KJ. Two-Year Treatment With Metformin During Puberty Does Not Preserve ß-Cell Function in Youth With Obesity. J Clin Endocrinol Metab. 2021 Jun 16;106(7):e2622-e2632. PubMed PMID: 33728428
  • Melena I, Bjornstad P, Schäfer M, Hunter KS, Barker AJ, Baumgartner A, Chung L, Wiromrat P, Truong U, Reusch JEB, Nadeau KJ. Serum copeptin and NT-proBNP is associated with central aortic stiffness and flow hemodynamics in adolescents with type 1 diabetes: A pilot study. J Diabetes Complications. 2021 May;35(5):107883. PubMed PMID: 33712333
  • Clark ELM, Gulley LD, Hilkin AM, Rockette-Wagner B, Leach HJ, Lucas-Thompson RG, Tanofsky-Kraff M, Nadeau KJ, Scott SM, Sheeder JL, Shomaker LB. Feasibility and Acceptability of Accelerometer Measurement of Physical Activity in Pregnant Adolescents. Int J Environ Res Public Health. 2021 Feb 24;18(5). PubMed PMID: 33668149
  • Pyle L, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Nadeau KJ, Cree-Green M. Fasting plasma metabolomic profiles are altered by three days of standardized diet and restricted physical activity. Metabol Open. 2021 Mar;9:100085. PubMed PMID: 33665598
  • Mather KJ, Tjaden AH, Hoehn A, Nadeau KJ, Buchanan TA, Kahn SE, Arslanian SA, Caprio S, Atkinson KM, Cree-Green M, Utzschneider KM, Edelstein SL. Precision and accuracy of hyperglycemic clamps in a multicenter study. Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E797-E807. PubMed PMID: 33645253
  • Andrisse S, Garcia-Reyes Y, Pyle L, Kelsey MM, Nadeau KJ, Cree-Green M. Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome. J Endocr Soc. 2021 Apr 1;5(4):bvab008. PubMed PMID: 33644620
  • Bartlette K, Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Pyle L, Nadeau KJ, Cree-Green M, Diniz Behn C. Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration. Metabol Open. 2021 Mar;9:100078. PubMed PMID: 33511337
  • Mokhlesi B, Tjaden AH, Temple KA, Edelstein SL, Sam S, Nadeau KJ, Hannon TS, Manchanda S, Mather KJ, Kahn SE, Ehrmann DA, Van Cauter E. Obstructive Sleep Apnea, Glucose Tolerance, and ß-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2021 Apr;44(4):993-1001. PubMed PMID: 33547205
  • Kaar JL, Morelli N, Russell SP, Talker I, Moore JM, Inge TH, Nadeau KJ, Hawkins SMM, Aloia MS, Simon SL. Obstructive sleep apnea and early weight loss among adolescents undergoing bariatric surgery. Surg Obes Relat Dis. 2021 Apr;17(4):711-717. PubMed PMID: 33478907
  • Jobira B, Frank DN, Silveira LJ, Pyle L, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome. PLoS One. 2021;16(1):e0245219. PubMed PMID: 33465100
  • Simon SL, Higgins J, Melanson E, Wright KP Jr, Nadeau KJ. A Model of Adolescent Sleep Health and Risk for Type 2 Diabetes. Curr Diab Rep. 2021 Jan 15;21(2):4. PubMed PMID: 33449241
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  • Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2016 Jun;17(4):257-65. PubMed PMID: 26080650
  • Chan CL, Pyle L, Kelsey M, Newnes L, Zeitler PS, Nadeau KJ. Screening for type 2 diabetes and prediabetes in obese youth: evaluating alternate markers of glycemia - 1,5-anhydroglucitol, fructosamine, and glycated albumin. Pediatr Diabetes. 2016 May;17(3):206-11. PubMed PMID: 25652226
  • Kelsey MM, Bjornstad P, McFann K, Nadeau K. Testosterone concentration and insulin sensitivity in young men with type 1 and type 2 diabetes. Pediatr Diabetes. 2016 May;17(3):184-90. PubMed PMID: 25611822
  • Cree-Green M, Bergman BC, Coe GV, Newnes L, Baumgartner AD, Bacon S, Sherzinger A, Pyle L, Nadeau KJ. Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance. Obesity (Silver Spring). 2016 Nov;24(11):2399-2406. PubMed PMID: 27804265
  • Ohman-Hanson RA, Cree-Green M, Kelsey MM, Bessesen DH, Sharp TA, Pyle L, Pereira RI, Nadeau KJ. Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood. J Clin Endocrinol Metab. 2016 Dec;101(12):4808-4815. PubMed PMID: 27603898
  • Bacha F, Gidding SS, Pyle L, Levitt Katz L, Kriska A, Nadeau KJ, Lima JAC. Relationship of Cardiac Structure and Function to Cardiorespiratory Fitness and Lean Body Mass in Adolescents and Young Adults with Type 2 Diabetes. J Pediatr. 2016 Oct;177:159-166.e1. PubMed PMID: 27499218
  • Nadeau KJ, Anderson BJ, Berg EG, Chiang JL, Chou H, Copeland KC, Hannon TS, Huang TT, Lynch JL, Powell J, Sellers E, Tamborlane WV, Zeitler P. Youth-Onset Type 2 Diabetes Consensus Report: Current Status, Challenges, and Priorities. Diabetes Care. 2016 Sep;39(9):1635-42. PubMed PMID: 27486237
  • Katz LL, Anderson BJ, McKay SV, Izquierdo R, Casey TL, Higgins LA, Wauters A, Hirst K, Nadeau KJ. Correlates of Medication Adherence in the TODAY Cohort of Youth With Type 2 Diabetes. Diabetes Care. 2016 Nov;39(11):1956-1962. PubMed PMID: 27352955
  • Bjornstad P, Truong U, Pyle L, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Regensteiner JG, Reusch JE, Nadeau KJ. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complications. 2016 Aug;30(6):1103-10. PubMed PMID: 27133451
  • Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc. 2016 Mar 18;5(3):e002804. PubMed PMID: 26994128
  • Bjornstad P, Cherney DZ, Maahs DM, Nadeau KJ. Diabetic Kidney Disease in Adolescents With Type 2 Diabetes: New Insights and Potential Therapies. Curr Diab Rep. 2016 Feb;16(2):11. PubMed PMID: 26803647
  • Pyle L, Bergman BC, Nadeau KJ, Cree-Green M. Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined. Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E323-31. PubMed PMID: 26714848
  • Duca LM, Maahs DM, Schauer IE, Bergman BC, Nadeau KJ, Bjornstad P, Rewers M, Snell-Bergeon JK. Development and Validation of a Method to Estimate Insulin Sensitivity in Patients With and Without Type 1 Diabetes. J Clin Endocrinol Metab. 2016 Feb;101(2):686-95. PubMed PMID: 26672636
  • Klingensmith GJ, Pyle L, Nadeau KJ, Barbour LA, Goland RS, Willi SM, Linder B, White NH. Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience. Diabetes Care. 2016 Jan;39(1):122-9. PubMed PMID: 26628417
  • Brega AG, Thomas JF, Henderson WG, Batliner TS, Quissell DO, Braun PA, Wilson A, Bryant LL, Nadeau KJ, Albino J. Association of parental health literacy with oral health of Navajo Nation preschoolers. Health Educ Res. 2016 Feb;31(1):70-81. PubMed PMID: 26612050
  • Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2016 Jun;17(4):257-65. PubMed PMID: 26080650
  • Chan CL, Pyle L, Kelsey M, Newnes L, Zeitler PS, Nadeau KJ. Screening for type 2 diabetes and prediabetes in obese youth: evaluating alternate markers of glycemia - 1,5-anhydroglucitol, fructosamine, and glycated albumin. Pediatr Diabetes. 2016 May;17(3):206-11. PubMed PMID: 25652226
  • Kelsey MM, Bjornstad P, McFann K, Nadeau K. Testosterone concentration and insulin sensitivity in young men with type 1 and type 2 diabetes. Pediatr Diabetes. 2016 May;17(3):184-90. PubMed PMID: 25611822
  • Pyle L, Bergman BC, Nadeau KJ, Cree-Green M. Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot readily be determined. Am J Physiol Endocrinol Metab. 2015 Dec 29;:ajpendo.00368.2015. [Epub ahead of print] PubMed PMID: 26714848
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  • Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2015 Jun 17. [Epub ahead of print] PubMed PMID: 26080650
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  • TODAY Study Group. Safety and tolerability of the treatment of youth-onset type 2 diabetes: the TODAY experience. Diabetes Care. 2013 Jun;36(6):1765-71. PubMed PMID: 23704676
  • Mizokami-Stout K, Cree-Green M, Nadeau KJ. Insulin resistance in type 2 diabetic youth. Curr Opin Endocrinol Diabetes Obes. 2012 Aug;19(4):255-62. PubMed PMID: 22732484
  • Snell-Bergeon JK, Nadeau K. Cardiovascular disease risk in young people with type 1 diabetes. J Cardiovasc Transl Res. 2012 Aug;5(4):446-62. PubMed PMID: 22528676
  • Brumbaugh DE, Crume TL, Nadeau K, Scherzinger A, Dabelea D. Intramyocellular lipid is associated with visceral adiposity, markers of insulin resistance, and cardiovascular risk in prepubertal children: the EPOCH study. J Clin Endocrinol Metab. 2012 Jul;97(7):E1099-105. PubMed PMID: 22508709
  • Bacha F, Pyle L, Nadeau K, Cuttler L, Goland R, Haymond M, Levitsky L, Lynch J, Weinstock RS, White NH, Caprio S, Arslanian S, TODAY Study Group. Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study. Pediatr Diabetes. 2012 Aug;13(5):376-83. PubMed PMID: 22332798
  • Beck RW, Tamborlane WV, Bergenstal RM, Miller KM, DuBose SN, Hall CA, T1D Exchange Clinic Network. The T1D Exchange clinic registry. J Clin Endocrinol Metab. 2012 Dec;97(12):4383-9. PubMed PMID: 22996145
  • TODAY Study Group, Zeitler P, Hirst K, Pyle L, Linder B, Copeland K, Arslanian S, Cuttler L, Nathan DM, Tollefsen S, Wilfley D, Kaufman F. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med. 2012 Jun 14;366(24):2247-56. PubMed PMID: 22540912
  • Laffel L, Chang N, Grey M, Hale D, Higgins L, Hirst K, Izquierdo R, Larkin M, Macha C, Pham T, Wauters A, Weinstock RS, TODAY Study Group. Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study. Pediatr Diabetes. 2012 Aug;13(5):369-75. PubMed PMID: 22369102
  • Lawrence JM, Yi-Frazier JP, Black MH, Anderson A, Hood K, Imperatore G, Klingensmith GJ, Naughton M, Mayer-Davis EJ, Seid M, SEARCH for Diabetes in Youth Study Group. Demographic and clinical correlates of diabetes-related quality of life among youth with type 1 diabetes. J Pediatr. 2012 Aug;161(2):201-7.e2. PubMed PMID: 22361221
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Professional Memberships

  • American Diabetes Association, member
  • Pediatric Endocrine Society, member
  • The Endocrine Society, member
  • American Federation for Medical Research, member
  • Colorado Clinical & Translational Sciences Institute, SARC Co-Chair
  • Society of Pediatric Research, Elected Member, Past Western Board Member
  • American Academy of Pediatrics, Committee on Native American Child Health (CONACH)

Practice Locations

Barbara Davis Center for Diabetes Pediatric Clinic - CU Anschutz Medical Campus
1775 Aurora Ct
Suite A140
Aurora, CO 80045
303-724-2323

Children’s Colorado Outpatient Care at Briargate
4125 Briargate Pkwy
Colorado Springs, CO 80920
719-305-9000

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
Center Affiliations

Specialty Information

Specialties
  • Pediatrics, Board Certification
  • Pediatric Endocrinology, Board Certification
Conditions & Treatments
  • Child and Teen Health - Juvenile Diabetes
  • Endocrine System (Hormones)
  • Child and Teen Health
  • Endocrine System (Hormones) - Adrenal Diseases
  • Endocrine System (Hormones) - Thyroid Disease
  • Endocrine System (Hormones) - Thyroid Cancer
  • Endocrine System (Hormones) - Osteoporosis
  • Endocrine System (Hormones) - Lipidosis
  • Endocrine System (Hormones) - Endocrine Cancer (Parathyroid, Adrenal, Carcinoid)
  • Food, Nutrition and Metabolism - Obesity
  • Food, Nutrition and Metabolism
  • Food, Nutrition and Metabolism - Weight Loss Surgery
  • Heart and Circulation - Heart Diseases - Prevention
  • Heart and Circulation
  • Heart and Circulation - High Blood Pressure
  • Pregnancy and Reproduction - Endocrine Disorders
  • Pregnancy and Reproduction
  • Transgender Health
  • Wellness and Prevention - Exercise and Physical Fitness
  • Wellness and Prevention
  • Women's Health - Adolescent Reproductive Health - Adolescent Gynecology
  • Women's Health
  • Surgery - Weight Loss Surgery
  • Surgery
Clinical Interests
Type 2 Diabetes, Type 1 Diabetes, Polycystic Ovary Syndrome, Dislipidemia, Nonalcoholic Fatty Liver Disease, Hypertension, Obesity, Pediatric Endocrinology

Care Philosophy
I practice personalize medicine to find the best treatment for each individual patient in a sensitive manner.

Personal Interests
Native American Child Health, Pediatric Physical Activity Promotion, Martial Arts, Pediatric LGBTQ+ Health, International Health

Volunteer Activities
Native American Child Health, Youth Sports Coaching, International Humanitarian Aid, Global Health, Homeless Shelters, Immigrant Rights, School Programs

Public Speaking
Yes
Pediatric Type 2 Diabetes, Insulin Resistance, Pediatric Type 1 Diabetes, Obesity, Metabolic Syndrome, Polycystic Ovarian Syndrome (PCOS), Bariatric Surgery, Prediabetes, Native American Child Health

General Information

Medical Schools:
  • MD, University of Wisconsin School of Medicine and Public Health (1998)
Residency Programs:
  • Oregon Health & Science University, Pediatrics (2001)
Fellowships:
  • University of Colorado, Pediatric Endocrinology (2004)
Languages: English
Department: Pediatrics-Endocrinology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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