Janet Wenzlau, PhD

Assistant Clinical Professor, Immunology and Microbiology

FacultyPhoto
Languages
English
Department
Immunology and Microbiology

Professional Titles

  • Instructor

Publications

  • J. M. M. Howson1, S. Krause2, H. Stevens1, N. Walker1, D. J. Smyth1, J. M. Wenzlau3, E. Bonifacio4, J. Hutton3, A. G. Ziegler2,5, J. A. Todd1 and P. Achenbach2,5. Genetic association of ZnT8 autoantibodiesin type 1 diabetes. Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies. (2012). Diabetologia;55(7):1978-84.
  • Yu L, Boulware DC, Beam CA, Hutton JC, Wenzlau JM, Greenbaum CJ, Bingley PJ, Krischer JP, Sosenko JM, Skyler JS, Eisenbarth GS, Mahon JL; Type 1 Diabetes TrialNet Study Group. (2012). Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies. Diabetes Care;35(6):1213-8.
  • Baker P, Fain P, Kahles H, Yu L, Hutton J, Wenzlau J, Rewers M, Badenhoop K, Eisenbarth G. Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics Consortium. (2012). J Clin Endocrinol Metab.;97(8):E1573-8.
  • Gottlieb PA, Yu L, Babu S, Wenzlau J, Bellin M, Frohnert BI, Moran A. No relation between cystic fibrosis-related diabetes and type 1 diabetes autoimmunity. (2012). Diabetes Care;35(8):e57.
  • Burbelo PD, Lebovitz EE, Bren KE, Bayat A, Paviol S, Wenzlau JM, Barriga KJ, Rewers M, Harlan DM, Iadarola MJ. Extrapancreatic autoantibody profiles in type I diabetes. (2012). PLoS One;7(9):e45216.
  • Mbunwe E, Van der Auwera BJ, Vermeulen I, Demeester S, Van Dalem A, Balti EV, Van Aken S, Derdelinckx L, Dorchy H, De Schepper J, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers D, Weets I, Gorus FK; Belgian Diabetes Registry. HLA-A*24 Is an Independent Predictor of 5-Year Progression to Diabetes in Autoantibody-Positive First-Degree Relatives of Type 1 Diabetic Patients. (2012). Diabetes Nov, 2012 (Epub ahead of print).
  • Gorus FK, Balti EV, Vermeulen I, Demeester S, Van Dalem A, Costa O, Dorchy H, Tenoutasse S, Mouraux T, De Block C, Gillard P, Decochez K, Wenzlau JM, Hutton JC, Pipeleers DG, Weets I; Belgian Diabetes Registry. Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients. (2013). Clin Exp Immunol;171(1):82-90.
  • Vermeulen I, Weets I, Costa O, Asanghanwa M, Verhaeghen K, Decochez K, Ruige J, Casteels K, Wenzlau J, Hutton JC, Pipeleers DG, Gorus FK. An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age. (2012). Diabetologia;55(2):413-20.
  • Wenzlau, J, Fain, P, Frisch, L, and John Hutton. ATPase4A autoreactivity and its association with autoimmune phenotypes in the T1DGC study. (2013) Diabetes Care.
  • E.V. Balti, S. Demeester, A. Van Dalem, O. Costa, H. Dorchy, S. Tenoutasse, T. Mouraux, C. De Block, P. Gillard, K. Decochez, J.M. Wenzlau, J.C. Hutton, D.G. Pipeleers, I. Weets, F.K. Gorus. Screening for IA-2 and zinc transporter 8 antibodie identifies relatives of type 1 diaebtic patients with a high and age-independent progression rate to clinical onset. 48th Annual Meeting for the European Association for the Study of Diabetes, Berlin, Germany, October 1-5, 2012.
  • Andrea K Steck, Liping Yu1, Fran Dong, Dongmei Miao, Janet Wenzlau, John Hutton, Marian J Rewers and George S Eisenbarth. Proinsulin/Insulin Autoantibodies Measured with Electrochemiluminescent Assay Are the Earliest Indicator of Prediabetic Islet Autoimmunity. Presentation at the 72nd Annual meeting of the American Diabetes Association, Philadelphia, PA, June 8-12, 2012.
  • Novel diabetes autoantibodies and prediction of type 1 diabetes. Wenzlau JM, Hutton JC. Curr Diab Rep. 2013 Oct;13(5):608-15. doi: 10.1007/s11892-013-0405-9. PMID: 23900975
  • Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients. Asanghanwa M, Gorus FK, Weets I, der Auwera BV, Aminkeng F, Mbunwe E, Goubert P, Verhaeghen K, Sobngwi E, Wenzlau JM, Hutton JC, Pipeleers DG, Keymeulen B, Mbanya JC, van Schravendijk C. Diabetes Res Clin Pract. 2014 Jan;103(1):97-105. doi: 10.1016/j.diabres.2013.11.013. Epub 2013 Nov 20. PMID: 24332797
  • In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions. Mbunwe E, Van der Auwera BJ, Weets I, Van Crombrugge P, Crenier L, Coeckelberghs M, Seret N, Decochez K, Vandemeulebroucke E, Gillard P, Keymeulen B, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry. Diabetologia. 2013 Sep;56(9):1964-70. doi: 10.1007/s00125-013-2951-8. Epub 2013 May 28. PMID: 23712485
  • Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity. Yu L, Dong F, Miao D, Fouts AR, Wenzlau JM, Steck AK. Diabetes Care. 2013 Aug;36(8):2266-70. doi: 10.2337/dc12-2245. Epub 2013 Feb 19. PMID: 23423694
  • Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients. Gorus FK, Balti EV, Vermeulen I, Demeester S, Van Dalem A, Costa O, Dorchy H, Tenoutasse S, Mouraux T, De Block C, Gillard P, Decochez K, Wenzlau JM, Hutton JC, Pipeleers DG, Weets I; Belgian Diabetes Registry. Clin Exp Immunol. 2013 Jan;171(1):82-90. doi: 10.1111/j.1365-2249.2012.04675.x. PMID: 23199327
  • HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients. Mbunwe E, Van der Auwera BJ, Vermeulen I, Demeester S, Van Dalem A, Balti EV, Van Aken S, Derdelinckx L, Dorchy H, De Schepper J, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers D, Weets I, Gorus FK; Belgian Diabetes Registry. Diabetes. 2013 Apr;62(4):1345-50. doi: 10.2337/db12-0747. Epub 2012 Nov 16. PMID: 23160529
  • Asanghanwa M, Gorus FK, Weets I, der Auwera BV, Aminkeng F, Mbunwe E, Goubert P, Verhaeghen K, Sobngwi E, Wenzlau JM, Hutton JC, Pipeleers DG, Keymeulen B, Mbanya JC, van Schravendijk C. Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: relation to autoantibody status and comparison with Belgian patients. Diabetes Res Clin Pract. 2014 Jan;103(1):97-105.PMID: 24332797
  • Davidson HW, Wenzlau JM, O'Brien RM. Zinc transporter 8 (ZnT8) and ß cell function. Trends Endocrinol Metab. 2014;25(8):415-24. PMID: 24751356
  • Chobot A, Wenzlau J, Bak-Drabik K, Kwiecien J, Polanska J, Rewers ATP4A autoimmunity and Helicobacter pylori infection in children with type 1 diabetes. M. Clin Exp Immunol. 2014;177(3):598-602. PMID: 24773566
  • Demeester S, Keymeulen B, Kaufman L, Van Dalem A, Balti EV, Van de Velde U, Goubert P, Verhaeghen K, Davidson HW, Wenzlau JM, Weets I, Pipeleers DG, Gorus FK. Preexisting Insulin Autoantibodies Predict Efficacy of Otelixizumab in Preserving Residual ß-Cell Function in Recent-Onset Type 1 Diabetes. Diabetes Care. 2015 12: dc141575. PMID: 25583753
  • Wenzlau JM, Fain PR, Gardner TJ, Frisch LM, Annibale B, Hutton JC. ATPase4A Autoreactivity and Its Association With Autoimmune Phenotypes in the Type 1 Diabetes Genetics Consortium Study.Diabetes Care. 2015 Oct;38 Suppl 2:S29-36. doi: 10.2337/dcs15-2006. PMID: 26405069
  • Wenzlau JM, Frisch LM, Hutton JC, Fain PR, Davidson HW. Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop. Diabetes Care. 2015;38 Suppl 2:S14-20. doi: 10.2337/dcs15-2004. PMID: 26405067
  • Brorsson CA, Onengut S, Chen WM, Wenzlau J, Yu L, Baker P, Williams AJ, Bingley PJ, Hutton JC, Eisenbarth GS, Concannon P, Rich SS, Pociot F; Type 1 Diabetes Genetics Consortium. Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes. Diabetes. 2015 Aug;64(8):3017-27. doi: 10.2337/db14-1730. PMID: 25829454
  • A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity; the findings of a UK population-based family study. Kozhakhmetova A, Wyatt RC, Caygill C, Williams C, Long AE, Chandler K, Aitken RJ, Wenzlau JM, Davidson HW, Gillespie KM, Williams AJK. Clin Exp Immunol. 2018 Feb 12.
  • ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12. Chobot A, Rusak E, Wenzlau J, Davidson H, Adamczyk P, Krzywicka A, Mazur B, Polanska J, Rewers M. Pediatr Diabetes. 2018 Feb;19(1):80-84
  • Luminescent Immunoprecipitation System (LIPS) for Detection of Autoantibodies Against ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase in Atrophic Body Gastritis Patients. Lahner E, Brigatti C, Marzinotto I, Carabotti M, Scalese G, Davidson HW, Wenzlau JM, Bosi E, Piemonti L, Annibale B, Lampasona V. Clin Transl Gastroenterol. 2017 Jan 19;8(1)
  • Development of Hybrid Insulin Peptides (HIPs) as Biomarkers Among Type 1 Diabetic (T1D) Individuals. Oral presentation at the Immunology of Diabetes Society 15th International Congress, San Francisco, California, January 19-23, 2017.
  • Antibodies to Hybrid Insulin Peptides in Type 1 Diabetes. Oral presentation at the JDRF nPOD 9th Annual Scientific Meeting, Ft. Lauderdale, Florida, February 19-22, 2017 combined with Rocky Baker.
  • ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12. Chobot A, Rusak E, Wenzlau J, Davidson H, Adamczyk P, Krzywicka A, Mazur B, Polanska J, Rewers M. Pediatr Diabetes. 2018 Feb;19(1):80-84.
  • A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. Kozhakhmetova A, Wyatt RC, Caygill C, Williams C, Long AE, Chandler K, Aitken RJ, Wenzlau JM, Davidson HW, Gillespie KM, Williams AJK. Clin Exp Immunol. 2018 Jun;192(3):251-258.
  • Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS). Lahner E, Marzinotto I, Brigatti C, Davidson H, Wenzlau J, Piemonti L, Annibale B, Lampasona V. Methods Mol Biol. 2019;1901:113-131.
  • Identification of autoantibodies to ZnT8 extracellular domain in patients with T1D Presentation at the 79th Scientific Sessions of the American Diabetes Association June 7 - 11, 2019, San Francisco, California
  • Rusak E, Chobot A, Krzywicka A, Wenzlau J. Anti-parietal cell antibodies - diagnostic significance. Adv Med Sci. 2016;61(2):175-179. Review. PMID: 26918709
  • Wenzlau, Janet. Zinc transporter 8 (ZnT8) autoantibodies [internet]. 2016 Apr 4; Diapedia 2105812817 rev. no. 9.
  • Antibodies Bind a Hybrid Insulin Peptide (HIP) Target in T1D Presentation at the 11th Annual meeting of nPOD. Hollywood, Florida, February 19-22, 2019.
  • J.M. Wenzlau, R. Howison, J. Walters, K. von Kraut, and H.W. Davidson. Mapping conformational ZnT8 epitopes for prediction of type 1 diabetes. Poster presentation at the 14th International Congress of the Immunology of Diabetes Society, Munich, Germany, April 12-16, 2015.
  • A. Chobot, E. Rusak, J. Wenzlau, K. Bak-Drabik, A. Krzywicka, A Rotarska-Mizera, J. Polanska, M. Rewers. Autoimmunity Towards Parietal Cells in Pediatric Patients with T1D. Poster presentation at the 49th Annual meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, Athens, Greece, May 25-28, 2016.
  • Identification of autoantibodies to ZnT8 extracellular domain in patients with T1D Presentation at the 79th Scientific Sessions of the American Diabetes Association June 7 - 11, 2019, San Francisco, California Additional Information:
  • Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B) Using a Luciferase Immunoprecipitation System (LIPS). Lahner E, Marzinotto I, Brigatti C, Davidson H, Wenzlau J, Piemonti L, Annibale B, Lampasona V. Methods Mol Biol. 2019;1901:113-131.
  • Antibodies Bind a Hybrid Insulin Peptide (HIP) Target in T1D Presentation at the 11th Annual meeting of nPOD. Hollywood, Florida, February 19-22, 2019.
  • Identification of Antibodies to Hybrid Insulin Peptides (HIPs) in T1D.Presentation at the 79th Scientific Sessions of the American Diabetes Association June 7 - 11, 2019, San Francisco, California


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