Andres Vazquez-Torres, PhD

Publications

• Kim JS, Liu L, Kant S, Orlicky DJ, Uppalapati S, Margolis A, Davenport BJ, Morrison TE, Matsuda J, McClelland M, Jones-Carson J, Vazquez-Torres A. Anaerobic respiration of host-derived methionine sulfoxide protects intracellular Salmonella from the phagocyte NADPH oxidase. Cell Host Microbe. 2024 Jan 24. [Epub ahead of print] PubMed PMID: 38307020
• Uppalapati S, Kant S, Liu L, Kim JS, Orlicky D, McClelland M, Vazquez-Torres A. Prophage terminase with tRNase activity sensitizes Salmonella enterica to oxidative stress. Science. 2024 Apr 5;384(6691):100-105. PubMed PMID: 38574144
• Kim JS, Liu L, Kant S, Orlicky DJ, Uppalapati S, Margolis A, Davenport BJ, Morrison TE, Matsuda J, McClelland M, Jones-Carson J, Vazquez-Torres A. Anaerobic respiration of host-derived methionine sulfoxide protects intracellular Salmonella from the phagocyte NADPH oxidase. Cell Host Microbe. 2024 Mar 13;32(3):411-424.e10. PubMed PMID: 38307020
• Kant S, Liu L, Vazquez-Torres A. The methylglyoxal pathway is a sink for glutathione in Salmonella experiencing oxidative stress. PLoS Pathog. 2023 Jun;19(6):e1011441. PubMed PMID: 37267419
• Margolis A, Liu L, Porwollik S, Till JKA, Chu W, McClelland M, Vázquez-Torres A. Arginine Metabolism Powers Salmonella Resistance to Oxidative Stress. Infect Immun. 2023 Jun 15;91(6):e0012023. PubMed PMID: 37191509
• Kant S, Till JKA, Liu L, Margolis A, Uppalapati S, Kim JS, Vazquez-Torres A. Gre factors help Salmonella adapt to oxidative stress by improving transcription elongation and fidelity of metabolic genes. PLoS Biol. 2023 Apr;21(4):e3002051. PubMed PMID: 37014914
• Kim JS, Born A, Till JKA, Liu L, Kant S, Henen MA, Vögeli B, Vázquez-Torres A. Promiscuity of response regulators for thioredoxin steers bacterial virulence. Nat Commun. 2022 Oct 20;13(1):6210. PubMed PMID: 36266276
• Uppalapati SR, Vazquez-Torres A. Manganese Utilization in Salmonella Pathogenesis: Beyond the Canonical Antioxidant Response. Front Cell Dev Biol. 2022;10:924925. PubMed PMID: 35903545
• Kim JS, Liu L, Davenport B, Kant S, Morrison TE, Vazquez-Torres A. Oxidative stress activates transcription of Salmonella pathogenicity island-2 genes in macrophages. J Biol Chem. 2022 Jul;298(7):102130. PubMed PMID: 35714768
• Kitzenberg DA, Lee JS, Mills KB, Kim JS, Liu L, Vázquez-Torres A, Colgan SP, Kao DJ. Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics. mBio. 2022 Jun 28;13(3):e0048022. PubMed PMID: 35575513
• Chakraborty S, Liu L, Fitzsimmons L, Porwollik S, Kim JS, Desai P, McClelland M, Vazquez-Torres A. Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ?pH. Nat Commun. 2020 Apr 14;11(1):1783. PubMed PMID: 32286292
• Jones-Carson J, Yahashiri A, Kim JS, Liu L, Fitzsimmons LF, Weiss DS, Vázquez-Torres A. Nitric oxide disrupts bacterial cytokinesis by poisoning purine metabolism. Sci Adv. 2020 Feb;6(9):eaaz0260. PubMed PMID: 32133408
• Fitzsimmons LF, Liu L, Kant S, Kim JS, Till JK, Jones-Carson J, Porwollik S, McClelland M, Vazquez-Torres A. SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. mBio. 2020 Feb 25;11(1). PubMed PMID: 32098823
• Pérez-Varela M, Tierney ARP, Kim JS, Vázquez-Torres A, Rather P. Characterization of RelA in Acinetobacter baumannii. J Bacteriol. 2020 May 27;202(12). PubMed PMID: 32229531
• Fang FC, Vázquez-Torres A. Reactive nitrogen species in host-bacterial interactions. Curr Opin Immunol. 2019 Oct;60:96-102. PubMed PMID: 31200187
• Fang FC, Vázquez-Torres A. Reactive nitrogen species in host-bacterial interactions. Curr Opin Immunol. 2019 Oct;60:96-102. PubMed PMID: 31200187
• Vazquez-Torres, A. 2018. Less is best in the convergent evolution of typhoidal Salmonella. Cell Host Microbe. S1931-3128(18)30044-1.
• 63. Fitzsimmons, L.F., L. Liu, J.S. Kim, J. Jones-Carson, and A. Vazquez-Torres. 2018. Salmonella reprograms nucleotide metabolism in its adaptation to nitrosative stress. mBio. 9: e00211-18. Mbo-mbio/mbo00118 /mbo3760d18z
• Kim JS, Liu L, Fitzsimmons LF, Wang Y, Crawford MA, Mastrogiovanni M, Trujillo M, Till JKA, Radi R, Dai S, Vázquez-Torres A. DksA-DnaJ redox interactions provide a signal for the activation of bacterial RNA polymerase. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11780-E11789. PubMed PMID: 30429329
• Davenport BJ, Martin CG, Beverley SM, Orlicky DJ, Vazquez-Torres A, Morrison TE. SODB1 is essential for Leishmania major infection of macrophages and pathogenesis in mice. PLoS Negl Trop Dis. 2018 Oct;12(10):e0006921. PubMed PMID: 30372439
• Fitzsimmons L, Liu L, Porwollik S, Chakraborty S, Desai P, Tapscott T, Henard C, McClelland M, Vazquez-Torres A. Zinc-dependent substrate-level phosphorylation powers Salmonella growth under nitrosative stress of the innate host response. PLoS Pathog. 2018 Oct;14(10):e1007388. PubMed PMID: 30365536
• Tapscott T, Kim JS, Crawford MA, Fitzsimmons L, Liu L, Jones-Carson J, Vázquez-Torres A. Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region. Sci Rep. 2018 Jun 21;8(1):9465. PubMed PMID: 29930310
• Shaw JA, Henard CA, Liu L, Dieckman LM, Vázquez-Torres A, Bourret TJ. Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway. J Biol Chem. 2018 Jul 20;293(29):11271-11282. PubMed PMID: 29848552
• Fitzsimmons LF, Liu L, Kim JS, Jones-Carson J, Vázquez-Torres A. Salmonella Reprograms Nucleotide Metabolism in Its Adaptation to Nitrosative Stress. MBio. 2018 Feb 27;9(1). PubMed PMID: 29487237
• Vázquez-Torres A. Less Is Best in the Convergent Evolution of Typhoidal Salmonella. Cell Host Microbe. 2018 Feb 14;23(2):151-153. PubMed PMID: 29447692
• Bourret TJ, Liu L, Shaw JA, Husain M, Vázquez-Torres A. Magnesium homeostasis protects Salmonella against nitrooxidative stress. Sci Rep. 2017 Nov 8;7(1):15083. PubMed PMID: 29118452
• Kao DJ, Saeedi BJ, Kitzenberg D, Burney KM, Dobrinskikh E, Battista KD, Vázquez-Torres A, Colgan SP, Kominsky DJ. Intestinal Epithelial Ecto-5'-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella. Infect Immun. 2017 Oct;85(10). PubMed PMID: 28717030
• Jones-Carson J, Husain M, Liu L, Orlicky DJ, Vázquez-Torres A. Cytochrome bd-Dependent Bioenergetics and Antinitrosative Defenses in Salmonella Pathogenesis. MBio. 2016 Dec 20;7(6). PubMed PMID: 27999164
• Fang FC, Frawley ER, Tapscott T, Vázquez-Torres A. Discrimination and Integration of Stress Signals by Pathogenic Bacteria. Cell Host Microbe. 2016 Aug 10;20(2):144-53. PubMed PMID: 27512902
• Fang FC, Frawley ER, Tapscott T, Vázquez-Torres A. Bacterial Stress Responses during Host Infection. Cell Host Microbe. 2016 Aug 10;20(2):133-43. PubMed PMID: 27512901
• Jarrett MJ, Vázquez-Torres A, Frank DN, McCollister BD, Henthorn PK, Ir D, Sheeder J, Guy MS, Anwar HQ, Behbakht K. Influence of Gelatin-Thrombin Matrix Tissue Sealant on Bacterial Colony Formation and Risk of Pelvic Infection. Infect Dis Obstet Gynecol. 2016;2016:2649708. PubMed PMID: 27199534
• Crawford MA, Tapscott T, Fitzsimmons LF, Liu L, Reyes AM, Libby SJ, Trujillo M, Fang FC, Radi R, Vázquez-Torres A. Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content. MBio. 2016 Apr 19;7(2):e02161-15. PubMed PMID: 27094335
• Crawford MA, Henard CA, Tapscott T, Porwollik S, McClelland M, Vázquez-Torres A. DksA-Dependent Transcriptional Regulation in Salmonella Experiencing Nitrosative Stress. Front Microbiol. 2016 Mar 31;7:444. PubMed PMID: 27065993
• Song M, Kim JS, Liu L, Husain M, Vázquez-Torres A. Antioxidant Defense by Thioredoxin Can Occur Independently of Canonical Thiol-Disulfide Oxidoreductase Enzymatic Activity. Cell Rep. 2016 Mar 29;14(12):2901-11. PubMed PMID: 26997275
• Vázquez-Torres A, Bäumler AJ. Nitrate, nitrite and nitric oxide reductases: from the last universal common ancestor to modern bacterial pathogens. Curr Opin Microbiol. 2016 Feb;29:1-8. PubMed PMID: 26426528
• 16. Tapscott, T., M.A. Crawford, & A. Vazquez-Torres. 2016. Transcriptional Regulation by Thiol-Based Sensors of Oxidative and Nitrosative Stress. In Stress and Environmental control of Gene Expression in Bacteria. Frans J. De Bruijn, Editor. Wiley-Blackwell. 955-966.
• Austin CR, Goodyear AW, Bartek IL, Stewart A, Sutherland MD, Silva EB, Zweifel A, Vitko NP, Tuanyok A, Highnam G, Mittelman D, Keim P, Schweizer HP, Vázquez-Torres A, Dow SW, Voskuil MI. A Burkholderia pseudomallei colony variant necessary for gastric colonization. MBio. 2015 Feb 3;6(1). PubMed PMID: 25650400
• Jones-Carson J, Zweifel AE, Tapscott T, Austin C, Brown JM, Jones KL, Voskuil MI, Vázquez-Torres A. Nitric oxide from IFN?-primed macrophages modulates the antimicrobial activity of ß-lactams against the intracellular pathogens Burkholderia pseudomallei and Nontyphoidal Salmonella. PLoS Negl Trop Dis. 2014 Aug;8(8):e3079. PubMed PMID: 25121731
• Henard CA, Tapscott T, Crawford MA, Husain M, Doulias PT, Porwollik S, Liu L, McClelland M, Ischiropoulos H, Vázquez-Torres A. The 4-cysteine zinc-finger motif of the RNA polymerase regulator DksA serves as a thiol switch for sensing oxidative and nitrosative stress. Mol Microbiol. 2014 Feb;91(4):790-804. PubMed PMID: 24354846
• Husain M, Jones-Carson J, Liu L, Song M, Saah JR, Troxell B, Mendoza M, Hassan H, Vázquez-Torres A. Ferric uptake regulator-dependent antinitrosative defenses in Salmonella enterica serovar Typhimurium pathogenesis. Infect Immun. 2014 Jan;82(1):333-40. PubMed PMID: 24166960
• 50. Song, M., J. Jones-Carson, C. Henard, M. Husain, A. Vazquez-Torres. 2013. Low-molecular weight thiol-dependent antioxidant and antinitrosative defenses in Salmonella pathogenesis. Mol. Microbiol. 87: 609-622. Epub 2012 Dec. 2.
• Henard, C.A., & A. Vazquez-Torres. 2013. Regulation of Salmonella resistance to oxidative and nitrosative stress. In The Regulation of Bacterial Virulence. M. Vasil and A. Darwin, Eds. ASM Press.
• Henard, C.A., & A. Vazquez-Torres. 2012. Regulation of Salmonella resistance to oxidative and nitrosative stress. In The Regulation of Bacterial Virulence. M. Vasil and A. Darwin, Eds. ASM Press.
• Vazquez-Torres, A. 2012. Redox active thiol sensors of oxidative and nitrosative stress. Antioxidants and Redox Signaling. 2012 Jan 18. [Epub ahead of print]
• 48. Henard, C.A., & A. Vazquez-Torres. 2012. DksA-dependent resistance of Salmonella enterica Serovar Typhimurium against the Antimicrobial Activity of Inducible Nitric Oxide Synthase. Infect. Immun. 80:1373-1380; published ahead of print 6 February 2012, doi:10.1128/IAI.06316-11 This article was selected by the Infect. Immun. Editorial Board to be presented as Spotlight in “The DksA RNA Polymerase Regulatory Protein Protects Salmonella enterica Serovar Typhimurium against Nutritional Stress Imposed by Nitric Oxide in the Phagosomal Lumen of Macrophages.”
• Jones-Carson, J., J.R. Laughlin, A.L. Stewart, M.I. Voskuil, A. Vázquez-Torres. 2012. Nitric oxide-dependent killing of aerobic, anaerobic and persistent Burkholderia pseudomallei. Nitric Oxide Chem. Biol. (in press).
• Hamad, M.A., C.R. Austin, A.L. Stewart, M. Higgins, A. Vazquez-Torres & M.I. Voskuil. 2011. Adaptation and antibiotic tolerance of anaerobic Burkholderia pseudomallei. Antimicrob Agents Chemother. 55:3313-23. Epub 2011 May 2.
• Zajdowicz, S.L.W., J. Jones-Carson, A. Vazquez-Torres, M.G. Jobling, R.E. Gill, & R.K. Holmes. 2011. Alanine Racemase Mutants of Burkholderia pseudomallei and Burkholderia mallei and Use of Alanine Racemase as a Non-Antibiotic-Based Selectable Marker. PLoS ONE. 6:e21523
• 5. McCollister, B.D., M. Hoffman, M. Husain, & A. Vazquez-Torres. Nitric oxide protects bacteria from aminoglycosides by blocking the energy-dependent phases of drug uptake. Antimicrob Agents Chemother. 2011 Feb 22. [Epub ahead of print].
• Henard, C.A., & A. Vazquez-Torres. 2011. Nitric oxide and Salmonella pathogenesis. Frontiers Cellular Infect. Microbiol (accepted for publication).
• Troxell, B., R.C. Fink, A. Vazquez-Torres, J. Jones-Carson, & H.M. Hasan. 2011. Fur Negatively Regulates hns and is Required for the Expression of HilA and Virulence in Salmonella enterica serovar Typhimurium. J. Bacteriol. 193: 497-505. Epub 2010 Nov 12.
• Schaack J, L. Qiao, M.P. Walkiewicz, M. Stonehouse, D.A. Engel, A. Vazquez-Torres, S.K. Nordeen, J. Shao, J.M. Moorhead. 2011. Insertion of CTCF-binding sites into a first-generation adenovirus vector reduces the innate inflammatory response and prolongs transgene expression. Virology. 2011 Jan 25. [Epub ahead of print]
• Evans, M.R., R.C. Fink, A. Vazquez-Torres, S. Porwollik, J. Jones-Carson, M. McClelland, & H.M. Hassan. Analysis of the ArcA regulon in anaerobically grown Salmonella enterica sv. Typhimurium. AMC Microbiol. (in press).
• Nitric oxide and Salmonella pathogenesis. Front. Microbio. 2:84. Doi:10.3389/fmicb.2011.00084
• 1. Maroof H., J. Jones-Carson, M. Song, B.D. McCollister, T.J. Bourret, & A. Vázquez-Torres. 2010. Redox sensor SsrB Cys203 enhances Salmonella fitness against nitric oxide generated in the host immune response to oral infection. Proc Natl Acad Sci U.S.A. 107:14396-401. Epub 2010 Jul 26.
• Henard, C.A., T.J. Bourret, M. Song, & A. Vazquez-Torres. 2010. Control of redox balance by the stringent response regulatory protein promotes antioxidant defenses of Salmonella. J. Biol. Chem. 285: 36785-93. Epub 2010 Sep 17.
• Hamad, M.A., C.R. Austin, A.L. Stewart, M. Higgins, A. Vazquez-Torres & M.I. Voskuil. Adaptation and antibiotic tolerance of anaerobic Burkholderia pseudomallei. Submitted for publication.
• Zajdowicz, S.L.W., J. Jones-Carson, A. Vazquez-Torres, M.G. Jobling, R.E. Gill1, & R.K. Holmes. Alanine Racemase Mutants of Burkholderia pseudomallei and Burkholderia mallei and Use of Alanine Racemase as a Non-Antibiotic-Based Selectable Marker. Submitted for publication.
• K.M. Rufner, N. French, B. McCollister, V. Lappi, N. Madinger, A. Vazquez-Torres, D. Guiney, D. Boxrud, J. Fierer, K.J. Gray, J. Nakiyingi, E. Lugada, J.A.G. Whitworth, J. Besser, C.F. Gilks, & E.N. Janoff. Microbiology of primary and recurrent Salmonella enterica bacteremia in adults with HIV co-infection in Uganda. Submitted for publication.
• Tapscott, T., J.S. Kim, M.A. Crawford, J. Westrich, L. Liu, J. Jones-Carson, and A. Vázquez-Torres. Salmonella pathogenesis requires negative regulation of SPI2 gene transcription by the AT-rich ssrA discriminator region. Submitted for publication.
• Jones-Carson, J, A. Yahashiri, L. Liu, J-S Kim, L.F. Fitzsimmons, D.S. Weiss and A. Vázquez-Torres. 2020. Nitric oxide disrupts bacterial cytokinesis by poisoning purine metabolism. Science Advances. Accepted for publication.
• Liam F. Fitzsimmons, Lin Liu, Sashi Kant, Ju-Sim Kim, James K. Till, Jessica Jones-Carson, Steffen Porwollik, Michael McClelland, and Andres Vazquez-Torres. 2020. The SpoT synthetase regulates intracellular Salmonella virulence programs in response to phagosomal acidity. mBio. Accepted for publication.