Lori Walker, PhD
Associate Professor, Medicine-Cardiology

Publications

• Tanner BCW, Awinda PO, Agonias KB, Attili S, Blair CA, Thompson MS, Walker LA, Kampourakis T, Campbell KS. Sarcomere length affects Ca2 sensitivity of contraction in ischemic but not non-ischemic myocardium. J Gen Physiol. 2023 Mar 6;155(3). PubMed PMID: 36633584
• Mueller MC, Du Y, Walker LA, Magin CM. Dynamically stiffening biomaterials reveal serum age and sex influence pulmonary arterial adventitial fibroblast activation in vitro. bioRxiv. 2023 Dec 15. PubMed PMID: 38168342
• Prin M, Bertazzo J, Walker LA, Scott B, Eckle T. Enhancing circadian rhythms-the circadian MEGA bundle as novel approach to treat critical illness. Ann Transl Med. 2023 Jun 30;11(9):319. PubMed PMID: 37404989
• McNair BD, Polson SM, Shorthill SK, Yusifov A, Walker LA, Weiser-Evans MCM, Kovacs EJ, Bruns DR. Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK. Am J Physiol Heart Circ Physiol. 2023 Aug 1;325(2):H278-H292. PubMed PMID: 37389952
• Brown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR. Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model. Am J Physiol Heart Circ Physiol. 2023 Jun 1;324(6):H804-H820. PubMed PMID: 36961489
• Tanner BCW, Awinda PO, Agonias KB, Attili S, Blair CA, Thompson MS, Walker LA, Kampourakis T, Campbell KS. Sarcomere length affects Ca2 sensitivity of contraction in ischemic but not non-ischemic myocardium. J Gen Physiol. 2023 Mar 6;155(3). PubMed PMID: 36633584
• Gillett L, Johnson-Sasso C, Miller B, Shakowski C, Walker LA, Tompkins C. Arrhythmic Effects of Cannabis in Ischemic Heart Disease. Cannabis Cannabinoid Res. 2023 Oct;8(5):867-876. PubMed PMID: 35353598
• Keller AC, Chun JH, Knaub LA, Henckel MM, Hull SE, Scalzo RL, Pott GB, Walker LA, Reusch JEB. Thermoneutrality induces vascular dysfunction and impaired metabolic function in male Wistar rats: a new model of vascular disease. J Hypertens. 2022 Nov 1;40(11):2133-2146. PubMed PMID: 35881464
• Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe KC, Bristow MR, Buttrick PM, Song K. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 Aug 30;146(9):699-714. PubMed PMID: 35862102
• Gillett L, Johnson-Sasso C, Miller B, Shakowski C, Walker LA, Tompkins C. Arrhythmic Effects of Cannabis in Ischemic Heart Disease. Cannabis Cannabinoid Res. 2022 Mar 29. [Epub ahead of print] PubMed PMID: 35353598
• Chun JH, Henckel MM, Knaub LA, Hull SE, Pott GB, Ramirez DG, Reusch JE, Keller AC. (-)-Epicatechin Reverses Glucose Intolerance in Rats Housed at Thermoneutrality. Planta Med. 2022 Aug;88(9-10):735-744. PubMed PMID: 35777366
• Knight WE, Ali HR, Nakano SJ, Wilson CE, Walker LA, Woulfe KC. Ex vivo Methods for Measuring Cardiac Muscle Mechanical Properties. Front Physiol. 2020;11:616996. PubMed PMID: 33488406
• Oyama Y, Walker LA, Eckle T. Targeting circadian PER2 as therapy in myocardial ischemia and reperfusion injury. Chronobiol Int. 2021 Sep;38(9):1262-1273. PubMed PMID: 34034593
• Woulfe KC, Walker LA. Physiology of the Right Ventricle Across the Lifespan. Front Physiol. 2021;12:642284. PubMed PMID: 33737888
• Knight WE, Cao Y, Lin YH, Chi C, Bai B, Sparagna GC, Zhao Y, Du Y, Londono P, Reisz JA, Brown BC, Taylor MRG, Ambardekar AV, Cleveland JC Jr, McKinsey TA, Jeong MY, Walker LA, Woulfe KC, D'Alessandro A, Chatfield KC, Xu H, Bristow MR, Buttrick PM, Song K. Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy. Stem Cell Reports. 2021 Mar 9;16(3):519-533. PubMed PMID: 33636116
• Peters CH, Myers ME, Juchno J, Haimbaugh C, Bichraoui H, Du Y, Bankston JR, Walker LA, Proenza C. Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18079-18090. PubMed PMID: 32647060
• Keller A, Hull SE, Elajaili H, Johnston A, Knaub LA, Chun JH, Walker L, Nozik-Grayck E, Reusch JEB. (-)-Epicatechin Modulates Mitochondrial Redox in Vascular Cell Models of Oxidative Stress. Oxid Med Cell Longev. 2020;2020:6392629. PubMed PMID: 32587663
• Knight WE, Ali HR, Nakano SJ, Wilson CE, Walker LA, Woulfe KC. Ex vivo Methods for Measuring Cardiac Muscle Mechanical Properties. Front Physiol. 2020;11:616996. PubMed PMID: 33488406
• Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1221-H1230. PubMed PMID: 31625780
• Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 Aug 6;28(6):1471-1484.e11. PubMed PMID: 31390562
• Bruns DR, Tatman PD, Kalkur RS, Brown RD, Stenmark KR, Buttrick PM, Walker LA. The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation. PLoS One. 2019;14(8):e0220573. PubMed PMID: 31374110
• Chi C, Leonard A, Knight WE, Beussman KM, Zhao Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K. LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):556-565. PubMed PMID: 30584088
• Bruns DR, Walker LA. Exercise and Pharmacology as Medicine for Cardiovascular Diseases: From Bench to Bedside and Back. Exerc Sport Sci Rev. 2018 Jan;46(1):2-3. PubMed PMID: 28902725
• Keller AC, Knaub LA, Scalzo RL, Hull SE, Johnston AE, Walker LA, Reusch JEB. Sepiapterin Improves Vascular Reactivity and Insulin-Stimulated Glucose in Wistar Rats. Oxid Med Cell Longev. 2018;2018:7363485. PubMed PMID: 30344886
• Johnson-Sasso CP, Tompkins C, Kao DP, Walker LA. Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction. PLoS One. 2018;13(7):e0199705. PubMed PMID: 29995914
• Scalzo RL, Knaub LA, Hull SE, Keller AC, Hunter K, Walker LA, Reusch JEB. Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats. Physiol Rep. 2018 Jul;6(13):e13754. PubMed PMID: 29984491
• Bruns DR, Walker LA. Exercise and Pharmacology as Medicine for Cardiovascular Diseases: From Bench to Bedside and Back. Exerc Sport Sci Rev. 2018 Jan;46(1):2-3. PubMed PMID: 28902725
• Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA. Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. World J Cardiol. 2017 Aug 26;9(8):673-684. PubMed PMID: 28932356
• Bartman CM, Oyama Y, Brodsky K, Khailova L, Walker L, Koeppen M, Eckle T. Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms. PLoS One. 2017;12(4):e0176243. PubMed PMID: 28448534
• Bruns DR, Buttrick PM, Walker LA. Genetic Ablation of Interleukin-18 Does Not Attenuate Hypobaric Hypoxia Induced Right Ventricular Hypertrophy. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 8;:ajplung.00166.2015. [Epub ahead of print] PubMed PMID: 26747780
• Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE. Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxid Med Cell Longev. 2016;2016:8524267. PubMed PMID: 27034743
• Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC. Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nat Commun. 2016 Mar 4;7:10830. PubMed PMID: 26940659
• Bruns DR, Buttrick PM, Walker LA. Genetic ablation of interleukin-18 does not attenuate hypobaric hypoxia-induced right ventricular hypertrophy. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15;310(6):L542-50. PubMed PMID: 26747780
• Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015 Sep 10;6:8243. PubMed PMID: 26354680
• Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L158-67. PubMed PMID: 25416385
• Seo SW, Koeppen M, Bonney S, Gobel M, Thayer M, Harter PN, Ravid K, Eltzschig HK, Mittelbronn M, Walker L, Eckle T. Differential Tissue-Specific Function of Adora2b in Cardioprotection. J Immunol. 2015 Aug 15;195(4):1732-43. PubMed PMID: 26136425
• Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L158-67. PubMed PMID: 25416385
• Thoemmes SF, Stutzke CA, Du Y, Browning MD, Buttrick PM, Walker LA. Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation. J Immunol Methods. 2014 Jan 31;403(1-2):66-71. PubMed PMID: 24291343
• Thoemmes SF, Stutzke CA, Du Y, Browning MD, Buttrick PM, Walker LA. Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation. J Immunol Methods. 2014 Jan 31;403(1-2):66-71. PubMed PMID: 24291343
• Sutliff RL, Walp ER, Kim YH, Walker LA, El-Ali AM, Ma J, Bonsall R, Ramosevac S, Eaton DC, Verlander JW, Hansen L, Gleason RL Jr, Pham TD, Hong S, Pech V, Wall SM. Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling. PLoS One. 2014;9(8):e105101. PubMed PMID: 25148130
• Kwartler CS, Chen J, Thakur D, Li S, Baskin K, Wang S, Wang ZV, Walker L, Hill JA, Epstein HF, Taegtmeyer H, Milewicz DM. Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells. J Biol Chem. 2014 May 16;289(20):14075-88. PubMed PMID: 24711452
• Bonney S, Kominsky D, Brodsky K, Eltzschig H, Walker L, Eckle T. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 2013;8(8):e71493. PubMed PMID: 23977055
• Walker LA, Fullerton DA, Buttrick PM. Contractile protein phosphorylation predicts human heart disease phenotypes. Am J Physiol Heart Circ Physiol. 2013 Jun 15;304(12):H1644-50. PubMed PMID: 23564307
• Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease: updated. Curr Cardiol Rev. 2013 Feb 1;9(1):73-81. PubMed PMID: 23092273
• Bonney S, Hughes K, Harter PN, Mittelbronn M, Walker L, Eckle T. Cardiac period 2 in myocardial ischemia: clinical implications of a light dependent protein. Int J Biochem Cell Biol. 2013 Mar;45(3):667-71. PubMed PMID: 23291353
• Lewandowski ED, Fischer SK, Fasano M, Banke NH, Walker LA, Huqi A, Wang X, Lopaschuk GD, O'Donnell JM. Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy. Circ Res. 2013 Jan 4;112(1):57-65. PubMed PMID: 22982985
• Woulfe, K.C. and Walker, L.A. Physiology of the right ventricle across the lifespan.Front. Physiol. - Clinical and Translational Physiology, in press