Sarah Faubel, MD

Clinical Professor, Medicine-Renal Med Diseases/Hypertension

FacultyPhoto
Medical School
  • MD, Wayne State University School of Medicine (1995)
Undergraduate School
  • BA, Wellesley College (MA) (1990)
Internship
  • Detroit Medical Center Program (1996)
Residency
  • University of Colorado (University Hospital) Program, Internal Medicine (1999)
Fellowships
  • University of Colorado (University Hospital) Program, Nephrology (2003)
Languages
English
Department
Medicine-Renal Med Diseases/Hypertension

Publications

  • Tao Y, Kim J, Faubel S, Wu JC, Falk SA, Schrier RW, Edelstein CL. Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease. Proc Natl Acad Sci U S A. 2005 May 10;102(19):6954-9.
  • Faubel S, Ljubanivic D, Poole B, Durson B, He Z, Cushing S, Somerset H, Gill RG, Edelstein CL. Peripheral CD4+ T cell depletion is not sufficient to prevent ischemic acute renal failure. Transplantation. 2005; Sept 15;80(5):643-9.
  • Faubel S, Edelstein CL. Caspases as drug targets in ischemic organ injury. Current Drug Targets-Immune, Endocrine and Metabolic Disorders. 2005, 5, 269-287.
  • Jani A, Wang W, Faubel S, Falk S, Ljubanovic D, Dursun B, Edelstein CL. Faubel S, Edelstein CL. Ischemic acute renal failure following nephrectomy impairs long-term renal function. Transplantation. 2006 Mar 15; 91 (5):800-3.
  • Edelstein CL, Hoke TS, Somerset H, Fang W, Klein CL, Dinarello CA, Faubel S. Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury. Nephrol Dial Transplant. 2007 Jan 25;
  • Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Related Articles, Links Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007 Jan;18(1):155-64.
  • Dursun B, He Z, Somerset H, Oh DJ, Faubel S, Edelstein CL. Related Articles, Links Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis. Am J Physiol Renal Physiol. 2006 Sep;291(3):F578-87.
  • Jani A, Wang W, Faubel S, Falk S, Ljubanovic D, Dursun B, Edelstein CL. Related Articles, Links Ischemic acute renal failure following nephrectomy impairs long-term renal function. Transplantation. 2006 Mar 15;81(5):800-3.
  • Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, Oh DJ, Lu L, Klein CL, Dinarello CA, Edelstein CL. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007 Jul;322(1):8-15
  • Tao Y, Kim J, Yin Y, Zafar I, Falk S, He Z, Faubel S, Schrier RW, Edelstein CL. VEGF receptor inhibition slows the progression of polycystic kidney disease. Kidney Int. 2007 Sep 19
  • Lu L, Oh DJ, Dursun B, He Z, Hoke T, Faubel S, Edelstein CL. Increased macrophage infiltration and fractalkine expression in cisplatin-induced acute renal failure in mice. J Pharmacol Exp Ther. 2007 Oct 11.
  • Oh DJ, Dursun B, He Z, Lu L, Hoke TS, Ljubanovic D, Faubel S, Edelstein CL. Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Am J Physiol Renal Physiol. 2007 Nov 14
  • Wang W, Zolty E, Falk S, Summer S, Zhou Z, Gengaro P, Faubel S, and Schrier RW. Endotoxemia-Related Acute kidney injury in Transgenic Mice with Endothelial Overexpression of GTP Cyclohydrolase-1 (GTPCH). Am J Physiol Renal Physiol. 2007 Dec 20
  • Macrophages are not a source of injurious interleukin-18 (IL-18) in ischemic acute Kidney injury (AKI) in mice. He Z, Dursun B, Oh D, Lu L, Faubel S, Edelstein CL. Am J Physiol Renal Physiol. 2009 Jan 7. PMID: 19129255
  • Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury. He Z, Lu L, Altmann C, Hoke TS, Ljubanovic D, Jani A, Dinarello CA, Faubel S, Edelstein CL. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1414-21
  • Role of NF-kappaB and PI 3-kinase/Akt in TNF-alpha-induced cytotoxicity in microvascular endothelial cells. Zhou Z, Gengaro P, Wang W, Wang XQ, Li C, Faubel S, Rivard C, Schrier RW. Am J Physiol Renal Physiol. 2008 Oct;295(4):F932-41.
  • Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy. Klein CL, Hoke TS, Fang WF, Altmann CJ, Douglas IS, Faubel S. Kidney Int. 2008 Oct;74(7):901-9. Epub 2008 Jul 2.
  • Pulmonary complications after acute kidney injury. Faubel S.Adv Chronic Kidney Dis. 2008 Jul;15(3):284-96.
  • Exciting times in research regarding the definition, diagnosis, complications, and outcomes of acute kidney injury. Faubel S, Edelstein CL. Adv Chronic Kidney Dis. 2008 Jul;15(3):211-2.
  • Macrophages are not the source of injurious interleukin-18 in ischemic acute kidney injury in mice. He Z, Dursun B, Oh DJ, Lu L, Faubel S, Edelstein CL. Am J Phys Renal Phys. U2009U Mar;296(3):F535-42.
  • Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Liu KD, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S. Crit Care. 2009 Jul 1;13(4):R104.
  • Acute kidney injury and multiple organ dysfunction syndrome. Faubel S. Minerva Urol Nefrol. 2009 Sep;61(3):171-88. PMID: 19773721
  • Dennen P, Altmann C, Kaufman J, Klein C, Andres-Hernando A, Ahuja N, Cadnapaphornchai M, Keniston A and Faubel S. Urine IL-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery. Critical Care. 2010;14(5):R181.
  • Altmann C, Andres-Hernando A, Ahuja N, He Z, Edelstein CL, Faubel S. Alveolar Macrophages mediate lung inflammation in ischemic acute kidney injury in mice. 2011 In Revision, AJP renal.
  • Lee DW, Faubel S, and Edelstein CL. Cytokines in acute kidney injury. Clinical Nephrology, 2010. In press.
  • Faubel S. Biomarkers of Kidney Disease: Biomarkers of extra-renal complications of AKI. 1st Edition 2010.
  • Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury. Altmann C, Andres-Hernando A, McMahan RH, Ahuja N, He Z, Rivard CJ, Edelstein CL, Barthel L, Janssen WJ, Faubel S. Am J Physiol Renal Physiol. 2011 Nov 23. [Epub ahead of print] PMID:22114207
  • Acute kidney injury: Severity of illness scoring systems in acute kidney injury. Faubel S, Edelstein CL. Nat Rev Nephrol. 2011 Nov 1;8(1):8-10. doi: 10.1038/nrneph.2011.173. No abstract available. PMID:22045237
  • IL-33 exacerbates acute kidney injury. Akcay A, Nguyen Q, He Z, Turkmen K, Won Lee D, Hernando AA, Altmann C, Toker A, Pacic A, Ljubanovic DG, Jani A, Faubel S, Edelstein CL. J Am Soc Nephrol. 2011 Nov;22(11):2057-67.
  • In critically ill patients requiring CRRT, AKI is associated with increased respiratory failure and death versus ESRD. Walcher A, Faubel S, Keniston A, Dennen P. Ren Fail. 2011;33(10):935-42
  • Cytokines in acute kidney injury (AKI). Lee DW, Faubel S, Edelstein CL. Clin Nephrol. 2011 Sep;76(3):165-73. Review.
  • Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Redente EF, Jacobsen KM, Solomon JJ, Lara AR, Faubel S, Keith RC, Henson PM, Downey GP, Riches DW. Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L510-8.
  • Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice. Andrés-Hernando A, Altmann C, Ahuja N, Lanaspa MA, Nemenoff R, He Z, Ishimoto T, Simpson PA, Weiser-Evans MC, Bacalja J, Faubel S. Am J Physiol Renal Physiol. 2011 Oct;301(4):F907-16.
  • Apoptosis and autophagy in cold preservation ischemia. Turkmen K, Martin J, Akcay A, Nguyen Q, Ravichandran K, Faubel S, Pacic A, Ljubanovic D, Edelstein CL, Jani A. Transplantation. 2011 Jun 15;91(11):1192-7.
  • Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death. Okamura K, Dummer P, Kopp J, Qiu L, Levi M, Faubel S, Blaine J. PLoS One. 2013;8(1):
  • Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation. Sirota JC, Walcher A, Faubel S, Jani A, McFann K, Devarajan P, Davis CL, Edelstein CL. BMC Nephrol. 2013 Jan 17;14:17
  • Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice. Ahuja N, Andres-Hernando A, Altmann C, Bhargava R, Bacalja J, Webb RG, He Z, Edelstein CL, Faubel S. Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F864-72
  • Cytokine production increases and cytokine clearance decreases in mice with bilateral nephrectomy. Andres-Hernando A, Dursun B, Altmann C, Ahuja N, He Z, Bhargava R, Edelstein CE, Jani A, Hoke TS, Klein C, Faubel S
  • Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Amura CR, Renner B, Lyubchenko T, Faubel S, Simonian PL, Thurman JM. Mol Immunol. 2012 Oct;52(3-4):249-57
  • Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials. Okusa MD, Molitoris BA, Palevsky PM, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Faubel S, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene TH, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Clin J Am Soc Nephrol. 2012 May;7(5):851-5. doi: 10.2215/CJN.12811211. Epub 2012 Mar 22.
  • Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials. Okusa MD, Molitoris BA, Palevsky PM, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Faubel S, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene TH, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Clin J Am Soc Nephrol. 2012 May;7(5):851-5. doi: 10.2215/CJN.12811211. Epub 2012 Mar 22.
  • Ongoing clinical trials in AKI. Faubel S, Chawla LS, Chertow GM, Goldstein SL, Jaber BL, Liu KD; Acute Kidney Injury Advisory Group of the American Society of Nephrology. Clin J Am Soc Nephrol. 2012 May;7(5):861-73. doi: 10.2215/CJN.12191111. Epub 2012 Mar 22. Review.
  • Faubel S. Renal relevant radiology: introduction. Clin J Am Soc Nephrol. 2014 Feb;9(2):371-2. PubMed PMID: 24510108
  • Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013 Nov;1(6):e00153. PubMed PMID: 24400155
  • Faubel S. Have we reached the limit of mortality benefit with our approach to renal replacement therapy in acute kidney injury?. Am J Kidney Dis. 2013 Dec;62(6):1030-3. PubMed PMID: 24267387
  • Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-a antibodies. PLoS One. 2013;8(11):e79037. PubMed PMID: 24265742
  • Faubel S, Patel NU, Lockhart ME, Cadnapaphornchai MA. Renal Relevant Radiology: Use of Ultrasonography in Patients with AKI. Clin J Am Soc Nephrol. 2014 Feb;9(2):382-94. PubMed PMID: 24235286
  • Wang H, Capell W, Yoon JH, Faubel S, Eckel RH. Obesity development in caspase-1-deficient mice. Int J Obes (Lond). 2014 Jan;38(1):152-5. PubMed PMID: 23689355
  • Bhargava R, Janssen W, Altmann C, Andrés-Hernando A, Okamura K, Vandivier RW, Ahuja N, Faubel S. Intratracheal IL-6 protects against lung inflammation in direct, but not indirect, causes of acute lung injury in mice. PLoS One. 2013;8(5):e61405. PubMed PMID: 23667439
  • Goldstein SL, Jaber BL, Faubel S, Chawla LS, Acute Kidney Injury Advisory Group of American Society of Nephrology. AKI transition of care: a potential opportunity to detect and prevent CKD. Clin J Am Soc Nephrol. 2013 Mar;8(3):476-83. PubMed PMID: 23471414
  • Okamura K, Dummer P, Kopp J, Qiu L, Levi M, Faubel S, Blaine J. Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death. PLoS One. 2013;8(1):e54817. PubMed PMID: 23382978
  • Sirota JC, Walcher A, Faubel S, Jani A, McFann K, Devarajan P, Davis CL, Edelstein CL. Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation. BMC Nephrol. 2013 Jan 17;14:17. PubMed PMID: 23327592
  • Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu KD, Koyner JL, Conner MJ Jr. Preparing for renal replacement therapy in patients with the ebola virus disease. Blood Purif. 2014;38(3-4):276-85. PubMed PMID: 25675963
  • Lee DW, Faubel S, Edelstein CL. A pan caspase inhibitor decreases caspase-1, IL-1a and IL-1ß, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules. Ren Fail. 2015 Feb;37(1):144-50. PubMed PMID: 25310769
  • Hung KW, Blaine J, Faubel S. Dual therapy difficulties in angiotensin blockade for proteinuria: a teachable moment. JAMA Intern Med. 2014 Sep;174(9):1429-30. PubMed PMID: 25089763
  • Andres-Hernando A, Altmann C, Bhargava R, Okamura K, Bacalja J, Hunter B, Ahuja N, Soranno D, Faubel S. Prolonged acute kidney injury exacerbates lung inflammation at 7 days post-acute kidney injury. Physiol Rep. 2014 Jul 1;2(7). PubMed PMID: 25052489
  • Koyner JL, Cerdá J, Goldstein SL, Jaber BL, Liu KD, Shea JA, Faubel S, Acute Kidney Injury Advisory Group of the American Society of Nephrology. The daily burden of acute kidney injury: a survey of U.S. nephrologists on World Kidney Day. Am J Kidney Dis. 2014 Sep;64(3):394-401. PubMed PMID: 24815216
  • Faubel S. Renal relevant radiology: introduction. Clin J Am Soc Nephrol. 2014 Feb;9(2):371-2. PubMed PMID: 24510108
  • Faubel S, Patel NU, Lockhart ME, Cadnapaphornchai MA. Renal relevant radiology: use of ultrasonography in patients with AKI. Clin J Am Soc Nephrol. 2014 Feb;9(2):382-94. PubMed PMID: 24235286
  • Wang H, Capell W, Yoon JH, Faubel S, Eckel RH. Obesity development in caspase-1-deficient mice. Int J Obes (Lond). 2014 Jan;38(1):152-5. PubMed PMID: 23689355
  • de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE Jr, Pullen N, Okusa MD, Faubel S. Bridging Translation by Improving Preclinical Study Design in AKI. J Am Soc Nephrol. 2015 Dec;26(12):2905-16. PubMed PMID: 26538634
  • Faubel S, Edelstein CL. Mechanisms and mediators of lung injury after acute kidney injury. Nat Rev Nephrol. 2016 Jan;12(1):48-60. PubMed PMID: 26434402
  • Dobrinskikh E, Lewis L, Brian Doctor R, Okamura K, Lee MG, Altmann C, Faubel S, Kopp JB, Blaine J. Shank2 Regulates Renal Albumin Endocytosis. Physiol Rep. 2015 Sep;3(9). PubMed PMID: 26333830
  • Heung M, Faubel S, Watnick S, Cruz DN, Koyner JL, Mour G, Liu KD, Cerda J, Okusa MD, Lukaszewski M, Vijayan A. Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care. Clin J Am Soc Nephrol. 2015 Oct 7;10(10):1868-74. PubMed PMID: 26220818
  • Cerdá J, Liu KD, Cruz DN, Jaber BL, Koyner JL, Heung M, Okusa MD, Faubel S. Promoting Kidney Function Recovery in Patients with AKI Requiring RRT. Clin J Am Soc Nephrol. 2015 Oct 7;10(10):1859-67. PubMed PMID: 26138260
  • Rodell CB, Rai R, Faubel S, Burdick JA, Soranno DE. Local immunotherapy via delivery of interleukin-10 and transforming growth factor ß antagonist for treatment of chronic kidney disease. J Control Release. 2015 May 28;206:131-9. PubMed PMID: 25804871
  • Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu KD, Koyner JL, Conner MJ Jr. Preparing for renal replacement therapy in patients with the Ebola virus disease. Blood Purif. 2014;38(3-4):276-85. PubMed PMID: 25675963
  • Lee DW, Faubel S, Edelstein CL. A pan caspase inhibitor decreases caspase-1, IL-1a and IL-1ß, and protects against necrosis of cisplatin-treated freshly isolated proximal tubules. Ren Fail. 2015 Feb;37(1):144-50. PubMed PMID: 25310769
  • A Decline in intraoperative Renal Near Infrared Spectroscopy is associated with Adverse Outcomes in Children following Cardiac Surgery; Pediatric critical care medicine, Accepted for publication
  • Use of TIMP2xIGFBP7 for the early detection of AKI; American Journal of Kidney Diseases
  • Askenazi DJ, Heung M, Connor MJ Jr, Basu RK, Cerdá J, Doi K, Koyner JL, Bihorac A, Golestaneh L, Vijayan A, Okusa MD, Faubel S. Optimal Role of the Nephrologist in the Intensive Care Unit. Blood Purif. 2016 Dec 3;43(1-3):68-77. [Epub ahead of print] PubMed PMID: 27923227
  • Colbert JF, Schmidt EP, Faubel S, Ginde AA. Severe Sepsis Outcomes Among Hospitalizations With Inflammatory Bowel Disease. Shock. 2017 Feb;47(2):128-131. PubMed PMID: 27617672
  • Faubel S, Shah PB. Immediate Consequences of Acute Kidney Injury: The Impact of Traditional and Nontraditional Complications on Mortality in Acute Kidney Injury. Adv Chronic Kidney Dis. 2016 May;23(3):179-85. PubMed PMID: 27113694
  • Soranno DE, Rodell CB, Altmann C, Duplantis J, Andres-Hernando A, Burdick JA, Faubel S. Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in mice. Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F362-72. PubMed PMID: 26962109
  • Skrypnyk NI, Siskind LJ, Faubel S, de Caestecker MP. Bridging translation for acute kidney injury with better preclinical modeling of human disease. Am J Physiol Renal Physiol. 2016 May 15;310(10):F972-84. PubMed PMID: 26962107
  • Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A. Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment. Am J Kidney Dis. 2016 Jul;68(1):19-28. PubMed PMID: 26948834
  • Gist KM, Kaufman J, da Cruz EM, Friesen RH, Crumback SL, Linders M, Edelstein C, Altmann C, Palmer C, Jalal D, Faubel S. A Decline in Intraoperative Renal Near-Infrared Spectroscopy Is Associated With Adverse Outcomes in Children Following Cardiac Surgery. Pediatr Crit Care Med. 2016 Apr;17(4):342-9. PubMed PMID: 26914625
  • Faubel S, Edelstein CL. Mechanisms and mediators of lung injury after acute kidney injury. Nat Rev Nephrol. 2016 Jan;12(1):48-60. PubMed PMID: 26434402
  • Teixeira JP, Ambruso S, Griffin BR, Faubel S. Pulmonary Consequences of Acute Kidney Injury. Semin Nephrol. 2019 Jan;39(1):3-16. PubMed PMID: 30606405
  • Griffin BR, Jovanovich A, You Z, Palevsky P, Faubel S, Jalal D. Effects of Baseline Thrombocytopenia and Platelet Decrease Following Renal Replacement Therapy Initiation in Patients With Severe Acute Kidney Injury. Crit Care Med. 2018 Dec 21. [Epub ahead of print] PubMed PMID: 30585829
  • Griffin BR, Faubel S, Edelstein CL. Biomarkers of drug-induced kidney toxicity. Ther Drug Monit. 2018 Dec 10. [Epub ahead of print] PubMed PMID: 30531196
  • Barhight MF, Brinton J, Stidham T, Soranno DE, Faubel S, Griffin BR, Goebel J, Mourani PM, Gist KM. Increase in chloride from baseline is independently associated with mortality in critically ill children. Intensive Care Med. 2018 Dec;44(12):2183-2191. PubMed PMID: 30382307
  • Barhight MF, Soranno D, Faubel S, Gist KM. Fluid Management With Peritoneal Dialysis After Pediatric Cardiac Surgery. World J Pediatr Congenit Heart Surg. 2018 Nov;9(6):696-704. PubMed PMID: 30322362
  • SooHoo MM, Patel SS, Jaggers J, Faubel S, Gist KM. Acute Kidney Injury Defined by Fluid Corrected Creatinine in Neonates After the Norwood Procedure. World J Pediatr Congenit Heart Surg. 2018 Sep;9(5):513-521. PubMed PMID: 30157730
  • Gist KM, Cooper DS, Wrona J, Faubel S, Altmann C, Gao Z, Marino BS, Alten J, Hock KM, Mizuno T, Vinks AA, Joy MS, Wempe MF, Bennett MR, Goldstein SL. Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Ther Drug Monit. 2018 Apr;40(2):186-194. PubMed PMID: 29529007
  • SooHoo M, Griffin B, Jovanovich A, Soranno DE, Mack E, Patel SS, Faubel S, Gist KM. Acute kidney injury is associated with subsequent infection in neonates after the Norwood procedure: a retrospective chart review. Pediatr Nephrol. 2018 Jul;33(7):1235-1242. PubMed PMID: 29508077
  • Barhight MF, Lusk J, Brinton J, Stidham T, Soranno DE, Faubel S, Goebel J, Mourani PM, Gist KM. Hyperchloremia is independently associated with mortality in critically ill children who ultimately require continuous renal replacement therapy. Pediatr Nephrol. 2018 Jun;33(6):1079-1085. PubMed PMID: 29404689
  • Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney International (Accepted for publication, 10/2018) Benjamin M Fox1*, Hyo-Wook Gil1,2*, Lara Kirkbride-Romeo1, Rushita A. Bagchi 6,7, Sara A. Wennersten 6,7, Korey R. Haefner 6,7, Nataliya I Skrypnyk 1, Carolyn N Brown 1, Danielle E. Soranno 3, Katja Gist 4, Benjamin Griffin1, Anna Jovanovich1, Julie A Reisz 5, Matthew J Wither 5, Angelo D'Alessandro 5, Charles L Edelstein1,9, Nathan Clendenen 8, Timothy McKinsey 6,7, Christopher Altmann1, Sarah Faubel1,9
  • Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective Benjamin Griffin1, Katja Gist2, , Sarah Faubel1. Journal of Intensive Care Medicine (Accepted for publication, 12/2018)
  • Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Gist KM, Jovanovich A, Jalal D, Faubel S, Aftab M. Thrombocytopenia After Cardiopulmonary Bypass is Associated with Increased Morbidity and Mortality. Ann Thorac Surg. 2019 Dec 6. [Epub ahead of print] PubMed PMID: 31816284
  • Griffin BR, Kohtz PD, Bronsert M, Reece TB, Cleveland JC Jr, Fullerton DA, Faubel S, Aftab M. Postoperative Complications Are Not Elevated in Well-compensated ESRD Patients Undergoing Cardiac Surgery: End-Stage Renal Disease Cardiac Surgery Outcomes. J Surg Res. 2019 Nov 27. [Epub ahead of print] PubMed PMID: 31785887
  • Griffin BR, Thomson A, Yoder M, Francis I, Ambruso S, Bregman A, Feller M, Johnson-Bortolotto S, King C, Bonnes D, Dufficy L, Wu C, Bansal A, Tad-Y D, Faubel S, Jalal D. Continuous Renal Replacement Therapy Dosing in Critically Ill Patients: A Quality Improvement Initiative. Am J Kidney Dis. 2019 Dec;74(6):727-735. PubMed PMID: 31540789
  • Griffin BR, You Z, Holmen J, SooHoo M, Gist KM, Colbert JF, Chonchol M, Faubel S, Jovanovich A. Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis. PLoS One. 2019;14(6):e0217935. PubMed PMID: 31233518
  • Griffin BR, Wu C, O'Horo JC, Faubel S, Jalal D, Kashani K. The Association of Platelet Decrease Following Continuous Renal Replacement Therapy Initiation and Increased Rates of Secondary Infections. Crit Care Med. 2021 Feb 1;49(2):e130-e139. PubMed PMID: 33372743
  • Soranno DE, Gil HW, Kirkbride-Romeo L, Altmann C, Montford JR, Yang H, Levine A, Buchanan J, Faubel S. Matching Human Unilateral AKI, a Reverse Translational Approach to Investigate Kidney Recovery after Ischemia. J Am Soc Nephrol. 2019 Jun;30(6):990-1005. PubMed PMID: 31072827
  • Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Faubel S, Aftab M. Creatinine elevations from baseline at the time of cardiac surgery are associated with postoperative complications. J Thorac Cardiovasc Surg. 2020 Jun 26. [Epub ahead of print] PubMed PMID: 32739165
  • Gist KM, Faubel S. Infection Post-AKI: Should We Worry?. Nephron. 2020;144(12):673-676. PubMed PMID: 32564024
  • Faubel S. The author replies. Kidney Int. 2020 Jun;97(6):1301-1302. PubMed PMID: 32444098
  • Faubel S. SuPAR: a potential predictive biomarker for acute kidney injury. Nat Rev Nephrol. 2020 Jul;16(7):375-376. PubMed PMID: 32269303
  • Barhight MF, Brinton JT, Soranno DE, Faubel S, Mourani PM, Gist KM. Effects of hyperchloremia on renal recovery in critically ill children with acute kidney injury. Pediatr Nephrol. 2020 Jul;35(7):1331-1339. PubMed PMID: 32152726
  • Skrypnyk NI, Gist KM, Okamura K, Montford JR, You Z, Yang H, Moldovan R, Bodoni E, Blaine JT, Edelstein CL, Soranno DE, Kirkbride-Romeo LA, Griffin BR, Altmann C, Faubel S. IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int. 2020 May;97(5):966-979. PubMed PMID: 32081304
  • Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Gist KM, Jovanovich A, Jalal D, Faubel S, Aftab M. Thrombocytopenia After Cardiopulmonary Bypass Is Associated With Increased Morbidity and Mortality. Ann Thorac Surg. 2020 Jul;110(1):50-57. PubMed PMID: 31816284
  • Griffin BR, Faubel S, Edelstein CL. Biomarkers of Drug-Induced Kidney Toxicity. Ther Drug Monit. 2019 Apr;41(2):213-226. PubMed PMID: 30883514
  • Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int. 2019 Mar;95(3):590-610. PubMed PMID: 30709662
  • Griffin BR, Gist KM, Faubel S. Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective. J Intensive Care Med. 2019 Jan 17;:885066618824531. [Epub ahead of print] PubMed PMID: 30654681
  • Teixeira JP, Ambruso S, Griffin BR, Faubel S. Pulmonary Consequences of Acute Kidney Injury. Semin Nephrol. 2019 Jan;39(1):3-16. PubMed PMID: 30606405
  • Griffin BR, Jovanovich A, You Z, Palevsky P, Faubel S, Jalal D. Effects of Baseline Thrombocytopenia and Platelet Decrease Following Renal Replacement Therapy Initiation in Patients With Severe Acute Kidney Injury. Crit Care Med. 2019 Apr;47(4):e325-e331. PubMed PMID: 30585829
  • Circulating IL-6 mediates hepatic NGAL production during acute kidney injury Kidney International Senior author: S Faubel
  • Griffin BR, Kohtz PD, Bronsert M, Reece TB, Cleveland JC Jr, Fullerton DA, Faubel S, Aftab M. Postoperative Complications Are Not Elevated in Well-Compensated ESRD Patients Undergoing Cardiac Surgery: End-Stage Renal Disease Cardiac Surgery Outcomes. J Surg Res. 2020 Mar;247:136-143. PubMed PMID: 31785887
  • Griffin BR, Gist KM, Faubel S. Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective. J Intensive Care Med. 2020 May;35(5):415-424. PubMed PMID: 30654681
  • Park BD, Faubel S. Acute Kidney Injury and Acute Respiratory Distress Syndrome. Crit Care Clin. 2021 Oct;37(4):835-849. PubMed PMID: 34548136
  • Griffin BR, Ten Eyck P, Faubel S, Jalal D, Gallagher M, Bellomo R. Platelet Decreases following Continuous Renal Replacement Therapy Initiation as a Novel Risk Factor for Renal Nonrecovery. Blood Purif. 2021 Sep 14;:1-8. [Epub ahead of print] PubMed PMID: 34521084
  • Ambruso SL, Gil HW, Fox B, Park B, Altmann C, Bagchi RA, Baker PR 2nd, Reisz JA, Faubel S. Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion. Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L50-L64. PubMed PMID: 33949208
  • Brown CN, Atwood D, Pokhrel D, Holditch SJ, Altmann C, Skrypnyk NI, Bourne J, Klawitter J, Blaine J, Faubel S, Thorburn A, Edelstein CL. Surgical procedures suppress autophagic flux in the kidney. Cell Death Dis. 2021 Mar 5;12(3):248. PubMed PMID: 33674554
  • Soranno DE, Kirkbride-Romeo L, Wennersten SA, Ding K, Cavasin MA, Baker P, Altmann C, Bagchi RA, Haefner KR, Steinkühler C, Montford JR, Keith B, Gist KM, McKinsey TA, Faubel S. Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition. JACC Basic Transl Sci. 2021 Feb;6(2):119-133. PubMed PMID: 33665513
  • Griffin BR, Wu C, O'Horo JC, Faubel S, Jalal D, Kashani K. The Association of Platelet Decrease Following Continuous Renal Replacement Therapy Initiation and Increased Rates of Secondary Infections. Crit Care Med. 2021 Feb 1;49(2):e130-e139. PubMed PMID: 33372743
  • Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Faubel S, Aftab M. Creatinine elevations from baseline at the time of cardiac surgery are associated with postoperative complications. J Thorac Cardiovasc Surg. 2020 Jun 26. [Epub ahead of print] PubMed PMID: 32739165
  • Gist KM, Faubel S. Infection Post-AKI: Should We Worry?. Nephron. 2020;144(12):673-676. PubMed PMID: 32564024
  • Faubel S. The author replies. Kidney Int. 2020 Jun;97(6):1301-1302. PubMed PMID: 32444098
  • Faubel S. SuPAR: a potential predictive biomarker for acute kidney injury. Nat Rev Nephrol. 2020 Jul;16(7):375-376. PubMed PMID: 32269303
  • Barhight MF, Brinton JT, Soranno DE, Faubel S, Mourani PM, Gist KM. Effects of hyperchloremia on renal recovery in critically ill children with acute kidney injury. Pediatr Nephrol. 2020 Jul;35(7):1331-1339. PubMed PMID: 32152726
  • Skrypnyk NI, Gist KM, Okamura K, Montford JR, You Z, Yang H, Moldovan R, Bodoni E, Blaine JT, Edelstein CL, Soranno DE, Kirkbride-Romeo LA, Griffin BR, Altmann C, Faubel S. IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int. 2020 May;97(5):966-979. PubMed PMID: 32081304
  • Griffin BR, Teixeira JP, Ambruso S, Bronsert M, Pal JD, Cleveland JC, Reece TB, Fullerton DA, Faubel S, Aftab M. Stage 1 acute kidney injury is independently associated with infection following cardiac surgery. J Thorac Cardiovasc Surg. 2021 Apr;161(4):1346-1355.e3. PubMed PMID: 32007252
  • Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Gist KM, Jovanovich A, Jalal D, Faubel S, Aftab M. Thrombocytopenia After Cardiopulmonary Bypass Is Associated With Increased Morbidity and Mortality. Ann Thorac Surg. 2020 Jul;110(1):50-57. PubMed PMID: 31816284
  • Griffin BR, Kohtz PD, Bronsert M, Reece TB, Cleveland JC Jr, Fullerton DA, Faubel S, Aftab M. Postoperative Complications Are Not Elevated in Well-Compensated ESRD Patients Undergoing Cardiac Surgery: End-Stage Renal Disease Cardiac Surgery Outcomes. J Surg Res. 2020 Mar;247:136-143. PubMed PMID: 31785887
  • Griffin BR, Gist KM, Faubel S. Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective. J Intensive Care Med. 2020 May;35(5):415-424. PubMed PMID: 30654681
  • Hukriede NA, Soranno DE, Sander V, Perreau T, Starr MC, Yuen PST, Siskind LJ, Hutchens MP, Davidson AJ, Burmeister DM, Faubel S, de Caestecker MP. Experimental models of acute kidney injury for translational research. Nat Rev Nephrol. 2022 May;18(5):277-293. PubMed PMID: 35173348
  • Soranno DE, Baker P 2nd, Kirkbride-Romeo L, Wennersten SA, Ding K, Keith B, Cavasin MA, Altmann C, Bagchi RA, Haefner KR, Montford J, Gist KM, Vergnes L, Reue K, He Z, Elajaili H, Okamura K, Nozik E, McKinsey TA, Faubel S. Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury. Sci Rep. 2022 Jan 12;12(1):643. PubMed PMID: 35022484
  • Montford JR, Bauer C, Rahkola J, Reisz JA, Floyd D, Hopp K, Soranno DE, Klawitter J, Weiser-Evans MCM, Nemenoff R, Faubel S, Furgeson SB. 15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction. Am J Physiol Renal Physiol. 2022 Jan 1;322(1):F105-F119. PubMed PMID: 34866403
  • Maksimovic N, Eilbott DH, Cookmeyer T, Wan F, Rusz J, Nagarajan V, Haley SC, Maniv E, Gong A, Faubel S, Hayes IM, Bangura A, Singleton J, Palmstrom JC, Winter L, McDonald R, Jang S, Ai P, Lin Y, Ciocys S, Gobbo J, Werman Y, Oppeneer PM, Altman E, Lanzara A, Analytis JG. Evidence for a delocalization quantum phase transition without symmetry breaking in CeCoIn(5). Science. 2022 Jan 7;375(6576):76-81. PubMed PMID: 34855511
  • Griffin BR, Ten Eyck P, Faubel S, Jalal D, Gallagher M, Bellomo R. Platelet Decreases following Continuous Renal Replacement Therapy Initiation as a Novel Risk Factor for Renal Nonrecovery. Blood Purif. 2022;51(7):559-566. PubMed PMID: 34521084
  • Colbert JF, Griffin BR, Rolloff K, Erzen CL, Haeger SM, Altmann C, Okamura K, Campbell R, Teitelbaum I, Faubel S. Hepcidin Removal during Continuous Renal Replacement Therapy. Blood Purif. 2024;53(1):23-29. PubMed PMID: 37926081
  • Griffin BR, Bronsert M, Reece TB, Pal JD, Cleveland JC, Fullerton DA, Faubel S, Aftab M. Creatinine elevations from baseline at the time of cardiac surgery are associated with postoperative complications. J Thorac Cardiovasc Surg. 2022 Apr;163(4):1378-1387. PubMed PMID: 32739165
  • Okamura K, Lu S, He Z, Altmann C, Montford JR, Li AS, Lucia MS, Orlicky DJ, Weiser-Evans M, Faubel S. IL-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically defined murine model. Am J Physiol Renal Physiol. 2023 Sep 1;325(3):F328-F344. PubMed PMID: 37471421
  • Faubel S. Acute kidney injury causes and exacerbates cardiac dysfunction. Am J Physiol Renal Physiol. 2023 Jun 1;324(6):F568-F570. PubMed PMID: 37167275
  • Liberio BM, Seedorf G, Soranno DE, Montford JR, Faubel SG, Hernandez A, Abman SH, Gien J. Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups. Pediatr Res. 2023 Oct;94(4):1308-1316. PubMed PMID: 37138027
  • Submitted: Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice
  • To submit this month: Plasma Cystatin C Predicts Kidney Function Recovery in Patients Requiring Continuous Kidney Replacement Therapy for Acute Kidney Injury
  • Haeger SM, Okamura K, Li AS, He Z, Park BD, Budnick IM, Foulon N, Kennis M, Blaine RE, Miyazaki M, Campbell R, Jalal DI, Colbert JF, Brinton JT, Griffin BR, Faubel S. Cystatin C and Kidney Function Recovery in Patients Requiring Continuous KRT for Acute Kidney Injury. Clin J Am Soc Nephrol. 2024 Nov 1;19(11):1395-1404. PubMed PMID: 39167447
  • Vipler B, Merritt F, Arnold-Rehring S, Zimmer S, Adams J, Faubel S. Inquiry for the win: Fostering curiosity through a BINGO exercise in a longitudinally integrated clerkship. Med Teach. 2024 Jun 18;:1-4. [Epub ahead of print] PubMed PMID: 38889323
  • Baker PR 2nd, Li AS, Griffin BR, Gil HW, Orlicky DJ, Fox BM, Park B, Sparagna GC, Goff J, Altmann C, Elajaili H, Okamura K, He Z, Stephenson D, D'Alessandro A, Reisz JA, Nozik ES, Sucharov CC, Faubel S. Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice. Sci Rep. 2024 Jun 15;14(1):13862. PubMed PMID: 38879688
  • Birkelo BC, Brittain E, Guide A, Greevy RA, Matheny ME, Annis J, Richardson T, Faubel S, Siew ED. Heart failure subtype after acute kidney injury. BMC Nephrol. 2024 May 17;25(1):167. PubMed PMID: 38760794
  • Colbert JF, Griffin BR, Rolloff K, Erzen CL, Haeger SM, Altmann C, Okamura K, Campbell R, Teitelbaum I, Faubel S. Hepcidin Removal during Continuous Renal Replacement Therapy. Blood Purif. 2024;53(1):23-29. PubMed PMID: 37926081
  • In submission: Uremic Toxins and Mortality in Patients with AKI prior to CKRT (JASN)
  • Procalcitonin levels in septic and nonseptic subjects with AKI and ESKD prior to and during continuous kidney replacement therapy (CKRT) (In submission: Kidney 360)

Professional Memberships

  • American Medical Association, Member
  • American Society of Nephrology, Member
  • International Society of Nephrology, Member
  • National Kidney Foundation, Member

Practice Locations

Rocky Mountain Regional Veterans Administration Medical Center
1700 Wheeling St
Aurora, CO 80045
303-399-8020

Hospital Affiliation
  • Veterans Affairs Medical Center
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2010)
  • Nephrology, Board Certification (2010)

School of Medicine

CU Anschutz
Fitzsimons Building

13001 East 17th Place

Aurora, CO 80045

303.724.5375

School
General
Students