Stephanie Wesolowski, PhD

Associate Professor, Pediatrics-Neonatology

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Website

Graduate Schools
  • PhD, Cornell University (2007)
  • MS, University of Nebraska - Lincoln (2002)
Undergraduate School
  • BS, Michigan State University (MI) (2000)
Fellowships
  • University of Colorado (University Hospital) Program, Postdoctoral Research - Neonatology (2009)
Languages
English
Department
Pediatrics-Neonatology

Recognitions

  • Obesity, Travel Award, Keystone Symposium (2009)
  • Individual Postdoctoral Fellowship Award, NIH - NRSA (2008)
    -(2010)
  • Maynard Award for Graduate Research in Nutrition, Cornell (2006)
  • Widaman Distinguished Graduate Reseach Assistant, University of Nebraska (2001)
  • Junior Faculty Travel Award, DOHAD Congress (2011)
  • Career Development Award, NIH K01 (2010)
    -(2015)

Publications

  • Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. INCREASED AMINO ACID SUPPLY POTENTIATES GLUCOSE STIMULATED INSULIN SECRETION BUT DOES NOT INCREASE BETA CELL MASS IN FETAL SHEEP. Am J Physiol Endocrinol Metab. 2012 Dec 4. [Epub ahead of print] PubMed PMID: 23211516
  • Lavezzi JR, Thorn SR, O'Meara MC, Loturco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan;304(1):R50-8. PubMed PMID: 23135788
  • Grant WF, Nicol LE, Thorn SR, Grove KL, Friedman JE, Marks DL. Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. PLoS One. 2012;7(10):e48119. PubMed PMID: 23118937
  • Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
  • Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW Jr, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15;303(8):R861-9. PubMed PMID: 22933022
  • Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW Jr. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E352-64. PubMed PMID: 22649066
  • Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1483-92. PubMed PMID: 22454287
  • Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ß-cell mass in fetal sheep. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E352-62. PubMed PMID: 23211516
  • Lavezzi JR, Thorn SR, O'Meara MC, LoTurco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 1;304(1):R50-8. PubMed PMID: 23135788
  • Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
  • Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2014 Dec 16;:ajpendo.00396.2014. [Epub ahead of print] PubMed PMID: 25516551
  • Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;1(1):367-76. PubMed PMID: 25343274
  • Harvatine KJ, Robblee MM, Thorn SR, Boisclair YR, Bauman DE. Trans-10, cis-12 CLA dose-dependently inhibits milk fat synthesis without disruption of lactation in C57BL/6J mice. J Nutr. 2014 Dec;144(12):1928-34. PubMed PMID: 25320189
  • Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18;2(6). PubMed PMID: 24944291
  • Leamy LJ, Elo K, Nielsen MK, Thorn SR, Valdar W, Pomp D. Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss. PeerJ. 2014;2:e392. PubMed PMID: 24918027
  • Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E306-14. PubMed PMID: 25516551
  • Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;156(1):367-76. PubMed PMID: 25343274
  • Harvatine KJ, Robblee MM, Thorn SR, Boisclair YR, Bauman DE. Trans-10, cis-12 CLA dose-dependently inhibits milk fat synthesis without disruption of lactation in C57BL/6J mice. J Nutr. 2014 Dec;144(12):1928-34. PubMed PMID: 25320189
  • Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014;5(1):28. PubMed PMID: 24917928
  • Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18;2(6). PubMed PMID: 24944291
  • Leamy LJ, Elo K, Nielsen MK, Thorn SR, Valdar W, Pomp D. Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss. PeerJ. 2014;2:e392. PubMed PMID: 24918027
  • Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014;5(1):28. PubMed PMID: 24917928
  • Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE. Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 2014 Aug;63(8):2702-13. PubMed PMID: 24705404
  • Roberts VH, Pound LD, Thorn SR, Gillingham MB, Thornburg KL, Friedman JE, Frias AE, Grove KL. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. 2014 Jun;28(6):2466-77. PubMed PMID: 24563374
  • Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW Jr, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R920-8. PubMed PMID: 26224688
  • Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy C, Garza NG, Hay W, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 Jan 4. [Epub ahead of print] PubMed PMID: 28053000
  • Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol. 2016 Oct 26. [Epub ahead of print] PubMed PMID: 27780972
  • Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW Jr, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct;157(10):3788-3799. PubMed PMID: 27501184
  • Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE. Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 2014 Aug;63(8):2702-13. PubMed PMID: 24705404
  • Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R200-8. PubMed PMID: 27170658
  • Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW Jr, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 Jun;157(6):2447-60. PubMed PMID: 27049667
  • Roberts VH, Pound LD, Thorn SR, Gillingham MB, Thornburg KL, Friedman JE, Frias AE, Grove KL. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. 2014 Jun;28(6):2466-77. PubMed PMID: 24563374
  • Hay WW Jr, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug;105(8):881-9. PubMed PMID: 27028695
  • Ehrhardt RA, Foskolos A, Giesy SL, Wesolowski SR, Krumm CS, Butler WR, Quirk SM, Waldron MR, Boisclair YR. Increased plasma leptin attenuates adaptive metabolism in early lactating dairy cows. J Endocrinol. 2016 May;229(2):145-57. PubMed PMID: 26957637
  • Wesolowski SR, Hay WW Jr. Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production. Mol Cell Endocrinol. 2016 Nov 5;435:61-8. PubMed PMID: 26723529
  • Harris RA, Alcott CE, Sullivan EL, Takahashi D, McCurdy CE, Comstock S, Baquero K, Blundell P, Frias AE, Kahr M, Suter M, Wesolowski S, Friedman JE, Grove KL, Aagaard KM. Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model. Sci Rep. 2016 Nov 4;6:36123. PubMed PMID: 27811965
  • Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth restricted fetal sheep. J Physiol. 2017 Sep 22. [Epub ahead of print] PubMed PMID: 28940557
  • Brown LD, Kohn JR, Rozance PJ, Hay WW Jr, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R654-R663. PubMed PMID: 28179229
  • Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1;312(4):R492-R500. PubMed PMID: 28100476
  • Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 Mar;232(3):475-491. PubMed PMID: 28053000
  • Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):81-96. PubMed PMID: 27780972
  • Paulsen ME, Rosario FJ, Wesolowski SR, Powell TL, Jansson T. Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring. FASEB J. 2018 Oct 22;:fj201801015R. [Epub ahead of print] PubMed PMID: 30346829
  • Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 Sep 28. [Epub ahead of print] PubMed PMID: 30337225
  • Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. Pulsatile hyperglycemia increases insulin secretion but not pancreatic ß-cell mass in intrauterine growth-restricted fetal sheep. J Dev Orig Health Dis. 2018 Oct;9(5):492-499. PubMed PMID: 29973299
  • Wai SG, Rozance PJ, Wesolowski SR, Hay WW Jr, Brown LD. Prolonged amino acid infusion into intrauterine growth restricted fetal sheep increases leucine oxidation rates. Am J Physiol Endocrinol Metab. 2018 Sep 11. [Epub ahead of print] PubMed PMID: 30205012
  • Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 Jan 1;596(1):67-82. PubMed PMID: 28940557
  • Chang EI, Rozance PJ, Wesolowski SR, Nguyen LM, Shaw SC, Sclafani RA, Bjorkman KK, Peter AK, Hay W, Brown LD. Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep. J Endocrinol. 2019 Nov 1. [Epub ahead of print] PubMed PMID: 31751294
  • Chang EI, Wesolowski SR, Gilje EA, Baker PR 2nd, Reisz JA, D'Alessandro A, Hay WW Jr, Rozance PJ, Brown LD. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth restricted fetal sheep hindlimb. Am J Physiol Regul Integr Comp Physiol. 2019 Sep 4. [Epub ahead of print] PubMed PMID: 31483682
  • Jones AK, Rozance PJ, Brown LD, Goldstrohm DA, Hay WW Jr, Limesand SW, Wesolowski SR. Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E1-E10. PubMed PMID: 30964701
  • Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW Jr, Friedman JE, Wesolowski SR. Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R427-R440. PubMed PMID: 30758974
  • Paulsen ME, Rosario FJ, Wesolowski SR, Powell TL, Jansson T. Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring. FASEB J. 2019 Feb;33(2):2899-2909. PubMed PMID: 30346829
  • Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 Dec;18:25-41. PubMed PMID: 30337225
  • Wai SG, Rozance PJ, Wesolowski SR, Hay WW Jr, Brown LD. Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates. Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1143-E1153. PubMed PMID: 30205012
  • Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. Pulsatile hyperglycemia increases insulin secretion but not pancreatic ß-cell mass in intrauterine growth-restricted fetal sheep. J Dev Orig Health Dis. 2018 Oct;9(5):492-499. PubMed PMID: 29973299
  • Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 Jan 1;596(1):67-82. PubMed PMID: 28940557
  • Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW Jr, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E721-E733. PubMed PMID: 32830555
  • Boehmer BH, Baker PR, Brown LD, Wesolowski SR, Rozance PJ. Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep. J Endocrinol. 2020 Oct;247(1):115-126. PubMed PMID: 32756000
  • Zarate MA, Wesolowski SR, Nguyen LM, De Dios RK, Wilkening RB, Rozance PJ, Wright CJ. In utero inflammatory challenge induces an early activation of the hepatic innate immune response in late gestation fetal sheep. Innate Immun. 2020 Oct;26(7):549-564. PubMed PMID: 32538259
  • Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ß Cells in Late-Gestation Sheep. J Nutr. 2020 Aug 1;150(8):2061-2069. PubMed PMID: 32470982
  • Campodonico-Burnett W, Hetrick B, Wesolowski SR, Schenk S, Takahashi DL, Dean TA, Sullivan EL, Kievit P, Gannon M, Aagaard K, Friedman JE, McCurdy CE. Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates. Diabetes. 2020 Jul;69(7):1389-1400. PubMed PMID: 32354857
  • Chang EI, Rozance PJ, Wesolowski SR, Nguyen LM, Shaw SC, Sclafani RA, Bjorkman KK, Peter AK, Hay W Jr, Brown LD. Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep. J Endocrinol. 2019 Dec 19;244(2):339-352. PubMed PMID: 31751294
  • Brown LD, Palmer C, Teynor L, Boehmer BH, Stremming J, Chang EI, White A, Jones AK, Cilvik SN, Wesolowski SR, Rozance PJ. Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency. Reprod Sci. 2021 Oct 5. [Epub ahead of print] PubMed PMID: 34611848
  • Jones AK, Rozance PJ, Brown LD, Lorca RA, Julian CG, Moore LG, Limesand SW, Wesolowski SR. Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. Physiol Rep. 2021 Sep;9(18):e15033. PubMed PMID: 34558219
  • Rozance PJ, Wesolowski SR, Jonker SS, Brown LD. Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2021 Sep 1;321(3):R352-R363. PubMed PMID: 34287074
  • Elsakr JM, Zhao SK, Ricciardi V, Dean TA, Takahashi DL, Sullivan E, Wesolowski SR, McCurdy CE, Kievit P, Friedman JE, Aagaard KM, Edwards DRV, Gannon M. Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model. Sci Rep. 2021 Jun 21;11(1):12977. PubMed PMID: 34155315
  • Pendleton AL, Wesolowski SR, Regnault TRH, Lynch RM, Limesand SW. Dimming the Powerhouse: Mitochondrial Dysfunction in the Liver and Skeletal Muscle of Intrauterine Growth Restricted Fetuses. Front Endocrinol (Lausanne). 2021;12:612888. PubMed PMID: 34079518
  • White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ. Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab. 2021 Jun 1;320(6):E1138-E1147. PubMed PMID: 33938236
  • Cilvik SN, Wesolowski SR, Anthony RV, Brown LD, Rozance PJ. Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth. J Physiol. 2021 Jul;599(13):3403-3427. PubMed PMID: 33878802
  • Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD. IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus. Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E527-E538. PubMed PMID: 33427051
  • Boehmer BH, Wesolowski SR, Brown LD, Rozance PJ. Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep. J Nutr. 2021 Feb 1;151(2):312-319. PubMed PMID: 33326574
  • Sureshchandra S, Chan CN, Robino JJ, Parmelee LK, Nash MJ, Wesolowski SR, Pietras EM, Friedman JE, Takahashi D, Shen W, Jiang X, Hennebold JD, Goldman D, Packwood W, Lindner JR, Roberts CT Jr, Burwitz BJ, Messaoudi I, Varlamov O. Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques. Stem Cell Reports. 2022 Oct 18. [Epub ahead of print] PubMed PMID: 36332628
  • Moore LG, Wesolowski SR, Lorca RA, Murray AJ, Julian CG. Why is human uterine artery blood flow during pregnancy so high?. Am J Physiol Regul Integr Comp Physiol. 2022 Nov 1;323(5):R694-R699. PubMed PMID: 36094446
  • Stremming J, White A, Donthi A, Batt DG, Hetrick B, Chang EI, Wesolowski SR, Seefeldt MB, McCurdy CE, Rozance PJ, Brown LD. Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep. Front Physiol. 2022;13:954948. PubMed PMID: 36091374
  • Jones AK, Wang D, Goldstrohm DA, Brown LD, Rozance PJ, Limesand SW, Wesolowski SR. Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep. Am J Physiol Endocrinol Metab. 2022 Feb 1;322(2):E181-E196. PubMed PMID: 34957858
  • Maternal Western Diet is Associated with Distinct Preclinical Pediatric NAFLD Phenotypes in Juvenile Nonhuman Primate Offspring
  • Maternal Western-style diet induces inflammatory innate immune cell memory through hematopoietic stem and progenitor cells in macaque offspring
  • Greyslak KT, Hetrick B, Bergman BC, Dean TA, Wesolowski SR, Gannon M, Schenk S, Sullivan EL, Aagaard KM, Kievit P, Chicco AJ, Friedman JE, McCurdy CE. A Maternal Western-Style Diet Impairs Skeletal Muscle Lipid Metabolism in Adolescent Japanese Macaques. Diabetes. 2023 Dec 1;72(12):1766-1780. PubMed PMID: 37725952
  • Swenson KS, Wang D, Jones AK, Nash MJ, O'Rourke R, Takahashi DL, Kievit P, Hennebold JD, Aagaard KM, Friedman JE, Jones KL, Rozance PJ, Brown LD, Wesolowski SR. Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes. Diabetes. 2023 Sep 1;72(9):1214-1227. PubMed PMID: 37347736
  • Carroll DT, Elsakr JM, Miller A, Fuhr J, Lindsley SR, Kirigiti M, Takahashi DL, Dean TA, Wesolowski SR, McCurdy CE, Friedman JE, Aagaard KM, Kievit P, Gannon M. Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E577-E588. PubMed PMID: 37134140
  • Kyllo HM, Wang D, Lorca RA, Julian CG, Moore LG, Wilkening RB, Rozance PJ, Brown LD, Wesolowski SR. Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E556-E568. PubMed PMID: 37126847
  • Nash MJ, Dobrinskikh E, Soderborg TK, Janssen RC, Takahashi DL, Dean TA, Varlamov O, Hennebold JD, Gannon M, Aagaard KM, McCurdy CE, Kievit P, Bergman BC, Jones KL, Pietras EM, Wesolowski SR, Friedman JE. Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring. Cell Rep. 2023 Apr 25;42(4):112393. PubMed PMID: 37058409
  • Rozance PJ, Boehmer BH, Chang EI, Wesolowski SR, Brown LD. Chronic Fetal Leucine Infusion Increases Rate of Leucine Oxidation but Not of Protein Synthesis in Late Gestation Fetal Sheep. J Nutr. 2023 Feb;153(2):493-504. PubMed PMID: 36894241
  • Nash MJ, Dobrinskikh E, Janssen RC, Lovell MA, Schady DA, Levek C, Jones KL, D'Alessandro A, Kievit P, Aagaard KM, McCurdy CE, Gannon M, Friedman JE, Wesolowski SR. Maternal Western diet is associated with distinct preclinical pediatric NAFLD phenotypes in juvenile nonhuman primate offspring. Hepatol Commun. 2023 Feb 1;7(2):e0014. PubMed PMID: 36691970
  • Sureshchandra S, Chan CN, Robino JJ, Parmelee LK, Nash MJ, Wesolowski SR, Pietras EM, Friedman JE, Takahashi D, Shen W, Jiang X, Hennebold JD, Goldman D, Packwood W, Lindner JR, Roberts CT Jr, Burwitz BJ, Messaoudi I, Varlamov O. Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques. Stem Cell Reports. 2022 Dec 13;17(12):2595-2609. PubMed PMID: 36332628
  • Moore LG, Wesolowski SR, Lorca RA, Murray AJ, Julian CG. Why is human uterine artery blood flow during pregnancy so high?. Am J Physiol Regul Integr Comp Physiol. 2022 Nov 1;323(5):R694-R699. PubMed PMID: 36094446
  • Jones AK, Wang D, Goldstrohm DA, Brown LD, Rozance PJ, Limesand SW, Wesolowski SR. Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep. Am J Physiol Endocrinol Metab. 2022 Feb 1;322(2):E181-E196. PubMed PMID: 34957858

Professional Memberships

  • American Diabetes Association, Member
  • The Endocrine Society, Member
  • American Society of Animal Science (ASAS), Member
  • American Association for the Advancement of Science, Member

Practice Locations

Center Affiliations

Specialty Information

Specialties
  • Neonatal-Perinatal Medicine

School of Medicine

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303.724.5375

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