Ralph Quinones, MD
Clinical Professor, Pediatrics
Medical School
- MD, University of Michigan Medical School (1977)
Undergraduate School
- BS, University of Michigan (MI) (1973)
Internship
- University of Minnesota Program (1978)
Residency
- University of Minnesota Program, Pediatrics (1980)
Fellowships
- University of Minnesota Program, Pediatric BMT and Pediatric Immunology (1983)
- National Cancer Institute, Immunology (1987)
Languages
EnglishDepartment
PediatricsProfessional Titles
- Attending Physician
- Professor of Clinical Practice
Research Interests
I am involved in clinical trials of HSCT in children and in research concerning novel methods of graft engineering.Publications
- Kerby GS, Wagner BD, Popler J, Hay TC, Kopecky C, Wilcox SL, Quinones RR, Giller RH, Accurso FJ, Deterding RR. Abnormal infant pulmonary function in young children with neuroendocrine cell hyperplasia of infancy. Pediatr Pulmonol. 2012 Nov 20. [Epub ahead of print] PubMed PMID: 23169677
- Bercovitz RS, Quinones RR. A Survey of Transfusion Practices in Pediatric Hematopoietic Stem Cell Transplant Patients. J Pediatr Hematol Oncol. 2012 Nov 6. [Epub ahead of print] PubMed PMID: 23138113
- Levy JM, Tello T, Giller R, Wilkening G, Quinones R, Keating AK, Liu AK. Late effects of total body irradiation and hematopoietic stem cell transplant in children under 3 years of age. Pediatr Blood Cancer. 2012 Jul 27. [Epub ahead of print] PubMed PMID: 22848000
- Pediatric Post Hematopoietic Stem Cell Transplant Neutrophil Function. Michael W. Kent, Marguerite Kelher, Christopher Silliman, Ralph Quinones. Accepted and presented by Dr. Kent at the 2013 ASMT/CIBMTR meeting in 2/2013 in Salt Lake City
- Optimizing Cyclosporine Dosing Regimens to Achieve Therapeutic Levels as the Time of Allogeneic Bone Marrow Transplantation: A Pediatric Quality Improvement Intervention. Brandon Neuchterlein, Tracey Duncan, Janet Bathurst, Angela Peltz, Amy Keating, Ralph Quinones, John Craddock, Kelly Drake, Amy Carver, Michelle Finnerty, Roger Giller. Accepted and presented by Mr. Neuchterlein at the 2/2013 ASBMT/CIBMTR meeting in Salt Lake City.
- Graham DK, Maloney KM, Quinones, RR, Foreman NK, Keating AK, Giller RH, Greffe BS. Neoplastic Diseases. Current Diagnosis and Treatment: Pediatrics. Hay WW, Levin MJ, Deterding, RR, Abzug MJ, Sondheimer JM, eds. Lange Medical Books/McGraw-Hill, 21st edition, New York. 2012.
- Liang X, Branchford B, Greffe B, McGavran L, Carstens B, Meltesen L, Albano EA, Quinones R, Cook B, Graham DK. Dual ALK and MYC rearrangements leading to an aggressive variant of anaplastic large cell lymphoma. J Pediatr Hematol Oncol. 2013 Jul;35(5):e209-13. PubMed PMID: 23619105
- Kerby GS, Wagner BD, Popler J, Hay TC, Kopecky C, Wilcox SL, Quinones RR, Giller RH, Accurso FJ, Deterding RR. Abnormal infant pulmonary function in young children with neuroendocrine cell hyperplasia of infancy. Pediatr Pulmonol. 2013 Oct;48(10):1008-15. PubMed PMID: 23169677
- Brandon Nuechterlein, Angela Peltz, Kelly Drake, Michelle Finnerty, Amy Keating, John Craddock, Suzanne Smolik, Ralph Quinones, Roger Giller, Tracey Duncan, Janet Bathurst, Optimizing Cyclosporine Dosing Regimen to Achieve Therapeutic Levels at the Time of Allogeneic Bone Marrow Transplantation: A Pediatric Quality Improvement Intervention. Poster at 2013 BMT Tandem Meetings, Salt Lake City, UT. February 2013.
- Bercovitz RS, Quinones RR. A survey of transfusion practices in pediatric hematopoietic stem cell transplant patients. J Pediatr Hematol Oncol. 2013 Mar;35(2):e60-3. PubMed PMID: 23138113
- Mulcahy Levy JM, Tello T, Giller R, Wilkening G, Quinones R, Keating AK, Liu AK. Late effects of total body irradiation and hematopoietic stem cell transplant in children under 3 years of age. Pediatr Blood Cancer. 2013 Apr;60(4):700-4. PubMed PMID: 22848000
- Successful hematopoietic cell transplantation in patients with unique NF-kappaB essential modulator (NEMO) mutations. Abbott JK; Quinones RR; de la Morena MT; Gelfand EW. Bone Marrow Transplantation. 49(11):1446-7, 2014 Nov. [Letter]
- Abbott JK; Quinones RR; de la Morena MT; Gelfand EW. Successful hematopoietic cell transplantation in patients with unique NF-kappaB essential modulator (NEMO) mutations. Bone Marrow Transplantation. 49(11):1446-7, 2014
- Ballen KK, Logan BR, Laughlin MJ, He W, Ambruso DR, Armitage SE, Beddard RL, Bhatla D, Hwang WY, Kiss JE, Koegler G, Kurtzberg J, Nagler A, Oh D, Petz LD, Price TH, Quinones RR, Ratanatharathorn V, Rizzo JD, Sazama K, Scaradavou A, Schuster MW, Sender LS, Shpall EJ, Spellman SR, Sutton M, Weitekamp LA, Wingard JR, Eapen M. Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2015 Apr;21(4):688-95. doi: 10.1016/j.bbmt.2014.12.017. Epub 2014 Dec 24.
- Michael W. Kent, M.D., Marguerite R. Kelher, M.S., Christopher C. Silliman, M.D, Ph.D., Ralph Quinones, M.D. Neutrophil Function in Children following Allogeneic Hematopoietic Stem Cell Transplant. In Press in Pediatric Transplantation.
- Moreira DC, Ng CJ, Quinones R, Liang X, Chung DW, Di Paola J. Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome. J Thromb Haemost. 2016 Dec;14(12):2353-2355. PubMed PMID: 27622772
- Kent MW, Kelher MR, Silliman CC, Quinones R. Neutrophil function in children following allogeneic hematopoietic stem cell transplant. Pediatr Transplant. 2016 Aug;20(5):658-66. PubMed PMID: 27114335
- Moreira DC, Ng CJ, Quinones R, Liang X, Chung DW, Di Paola J. Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome. J Thromb Haemost. 2016 Dec;14(12):2353-2355. PubMed PMID: 27622772
- Kent MW, Kelher MR, Silliman CC, Quinones R. Neutrophil function in children following allogeneic hematopoietic stem cell transplant. Pediatr Transplant. 2016 Aug;20(5):658-66. PubMed PMID: 27114335
- Michniacki TF, Mulcahy Levy JM, Quinones RR, Giller RH. Successful correction of familial hemophagocytic lymphohistiocytosis using prenatal genetic testing and preemptive hematopoietic stem cell transplantation. Bone Marrow Transplant. 2017 Oct 16. [Epub ahead of print] PubMed PMID: 29035396
- Michniacki TF, Mulcahy Levy JM, Quinones RR, Giller RH. Successful correction of familial hemophagocytic lymphohistiocytosis using prenatal genetic testing and preemptive hematopoietic stem cell transplantation. Bone Marrow Transplant. 2018 Feb;53(2):223-224. doi: 10.1038/bmt.2017.219. Epub 2017 Oct 16.
- Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. Correction: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 3;216(6):1465. PubMed PMID: 31088899
- Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 3;216(6):1255-1267. PubMed PMID: 31040184
- Michniacki TF, Mulcahy Levy JM, Quinones RR, Giller RH. Successful correction of familial hemophagocytic lymphohistiocytosis using prenatal genetic testing and preemptive hematopoietic stem cell transplantation. Bone Marrow Transplant. 2018 Feb;53(2):223-224. PubMed PMID: 29035396
- Burroughs, LM, Pertrovic, A, Brazaukas, R, ... Quinones, RR, ... Cown, MJ. Excellent Outcomes Following Hematopoietic Cell Transplantation of Wiskott-Aldrich Syndrome: A PIDTC Report. Submitted to BLOOD
- Dorsey MJ, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, Chandra S, Chaudhury S, Chen K, Chong H, Cuvelier GDE, Dalal J, DeFelice ML, DeSantes KB, Forbes LR, Gillio A, Goldman F, Joshi AY, Kapoor N, Knutsen AP, Kobrynski L, Lieberman JA, Leiding JW, Oshrine B, Patel KP, Prockop S, Quigg TC, Quinones R, Schultz KR, Seroogy C, Shyr D, Siegel S, Smith AR, Torgerson TR, Vander Lugt MT, Yu LC, Cowan MJ, Buckley RH, Dvorak CC, Griffith LM, Haddad E, Kohn DB, Logan B, Notarangelo LD, Pai SY, Puck J, Pulsipher MA, Heimall J. Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers. J Clin Immunol. 2020 Oct 2. [Epub ahead of print] PubMed PMID: 33006109
- Koo J, Giller RH, Quinones R, McKinney CM, Verneris MR, Knight-Perry J. Autoimmune cytopenias following allogeneic hematopoietic stem cell transplant in pediatric patients: Response to therapy and late effects. Pediatr Blood Cancer. 2020 Jul 13;:e28591. [Epub ahead of print] PubMed PMID: 32658382
- Burroughs LM, Petrovic A, Brazauskas R, Liu X, Griffith LM, Ochs HD, Bleesing JJ, Edwards S, Dvorak CC, Chaudhury S, Prockop SE, Quinones R, Goldman FD, Quigg TC, Chandrakasan S, Smith AR, Parikh S, Dávila Saldaña BJ, Thakar MS, Phelan R, Shenoy S, Forbes LR, Martinez C, Chellapandian D, Shereck E, Miller HK, Kapoor N, Barnum JL, Chong H, Shyr DC, Chen K, Abu-Arja R, Shah AJ, Weinacht KG, Moore TB, Joshi A, DeSantes KB, Gillio AP, Cuvelier GDE, Keller MD, Rozmus J, Torgerson T, Pulsipher MA, Haddad E, Sullivan KE, Logan BR, Kohn DB, Puck JM, Notarangelo LD, Pai SY, Rawlings DJ, Cowan MJ. Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report. Blood. 2020 Jun 4;135(23):2094-2105. PubMed PMID: 32268350
- Haynes AS, Curtis DJ, Campbell K, Giller RH, Quinones RR, Verneris MR, Abzug MJ. An Immune Recovery-Based Revaccination Protocol for Pediatric Hematopoietic Stem Cell Transplant Recipients: Revaccination Outcomes Following Pediatric HSCT. Transplant Cell Ther. 2021 Apr;27(4):317-326. PubMed PMID: 33836875
- Dorsey M, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, Burroughs LM, Chandra S, Chaudhury S, Chen K, Chong H, Cuvelier G, Dalal J, DeFelice ML, DeSantes KB, Forbes LR, Gillio A, Goldman F, Joshi AY, Kapoor N, Knutsen AP, Kobrynski L, Lieberman JA, Leiding JW, Oshrine B, Patel KP, Prockop S, Quigg TC, Quinones R, Schultz KR, Seroogy C, Shyr D, Siegel S, Smith AR, Torgerson TR, Vander Lugt MT, Yu LC, Cowan MJ, Buckley RH, Dvorak CC, Griffith LM, Haddad E, Kohn DB, Logan B, Notarangelo LD, Pai SY, Puck J, Pulsipher MA, Heimall J. Correction to: Infections in Infants with SCID: Isolation, Infection Screening and Prophylaxis in PIDTC Centers. J Clin Immunol. 2021 Feb;41(2):498-500. PubMed PMID: 33274413
- Dorsey MJ, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, Chandra S, Chaudhury S, Chen K, Chong H, Cuvelier GDE, Dalal J, DeFelice ML, DeSantes KB, Forbes LR, Gillio A, Goldman F, Joshi AY, Kapoor N, Knutsen AP, Kobrynski L, Lieberman JA, Leiding JW, Oshrine B, Patel KP, Prockop S, Quigg TC, Quinones R, Schultz KR, Seroogy C, Shyr D, Siegel S, Smith AR, Torgerson TR, Vander Lugt MT, Yu LC, Cowan MJ, Buckley RH, Dvorak CC, Griffith LM, Haddad E, Kohn DB, Logan B, Notarangelo LD, Pai SY, Puck J, Pulsipher MA, Heimall J. Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers. J Clin Immunol. 2021 Jan;41(1):38-50. PubMed PMID: 33006109
- Koo J, Giller RH, Quinones R, McKinney CM, Verneris MR, Knight-Perry J. Autoimmune cytopenias following allogeneic hematopoietic stem cell transplant in pediatric patients: Response to therapy and late effects. Pediatr Blood Cancer. 2020 Sep;67(9):e28591. PubMed PMID: 32658382
- Burroughs LM, Petrovic A, Brazauskas R, Liu X, Griffith LM, Ochs HD, Bleesing JJ, Edwards S, Dvorak CC, Chaudhury S, Prockop SE, Quinones R, Goldman FD, Quigg TC, Chandrakasan S, Smith AR, Parikh S, Dávila Saldaña BJ, Thakar MS, Phelan R, Shenoy S, Forbes LR, Martinez C, Chellapandian D, Shereck E, Miller HK, Kapoor N, Barnum JL, Chong H, Shyr DC, Chen K, Abu-Arja R, Shah AJ, Weinacht KG, Moore TB, Joshi A, DeSantes KB, Gillio AP, Cuvelier GDE, Keller MD, Rozmus J, Torgerson T, Pulsipher MA, Haddad E, Sullivan KE, Logan BR, Kohn DB, Puck JM, Notarangelo LD, Pai SY, Rawlings DJ, Cowan MJ. Excellent outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome: a PIDTC report. Blood. 2020 Jun 4;135(23):2094-2105. PubMed PMID: 32268350
Professional Memberships
- Resident Selection Committee, Past Member
- American Association of Immunologists, Member
- American Society for the Advancement of Science, Member
- Chesapeake Transplant Society , Founding Member
- International Society for Hematotherapy and Graft Engineering , Member
- American Society of Blood and Marrow Transplantation, Member
- Foundation for Accreditation of Hematopoietic Cell Therapy, Inspector
Practice Locations
Children's Hospital Colorado Anschutz Medical Campus13123 East 16th Ave
Aurora, CO 80045
720-777-1234
Hospital Affiliation
- Children's Hospital Colorado
- University of Colorado Hospital
Center Affiliations
Specialty Information
Specialties- Pediatric Hematology / Oncology (1994)
- Blood / Lymphatic System - Blood Disorders
- Cancers - Pediatric Cancer
- Blood / Lymphatic System
- Cancers
- Immune System - Autoimmune Disorders
- Immune System
- Immune System - Immunodeficiency
Clinical Interests
My clinical interests have always centered on improving the care and outcomes of allogeneic Hematopoietic Cell Transplantation (HSCT) for all patients in need of an HSCT. As our BMT Team has grown, I am now able to focus on HSCT for children with life-threatening Non-Malignant Disorders. Specifically, as a Pediatric Immunologist, I have passion for HSCT to help children born with inherited Primary Immunodeficiency Disorders (PID), which includes all forms of Severe Combined Immunodeficiency Diseases (SCID, Wiskott Aldrich Syndrome, and many more). As well as the more recently recognized PIDs of Immune-Dysregulation (such as IPEX, Gain of Function STAT3, and other even rarer disorders that we are discovering with current gene sequencing techniques). I believe that better understanding the causes of both the Immunodeficiency PIDs and Immune-dysregulation PIDs will result in direct improvement in the outcomes for allogeneic HSCT in each group. My other clinical interests are in constantly improving the results for Unrelated Cord Blood Transplantation. Here, I have started with the source and am a Founder and Medical Director of the University of Colorado Cord Blood Bank, one of the largest public CB Banks in the world that has provided life-saving unrelated CB grafts for children and adults in BMT Centers around the world. My other interests include suing the immune system to fight Cancer, improving our knowledge of Blood Cell Biology, and understanding Graft Versus Host Disease, with the goals of better prevention and improved therapy and outcomes should GVHD occur.
Care Philosophy
My clinical philosophy has always been ‘Do the Right Thing for the Patient’. This means striving to provide the absolute best care, starting with diagnosis and throughout treatment, which relies on current and extensive knowledge of the biology and treatment of each of these relatively rare diseases, based on the scientific and medical knowledge, both in the literature and based on direct communication with other experts in the field. I have always believed and have seen repeatedly proven that greater scientific understanding of a disease process and how it harms the patient improves our care and ability to cure that disease. I also believe that recognizing and carefully considering the patient’s specific problems and needs in the context of their disease and its biology, allows for the informed changing or customizing the approach if required. As we define more disease using gene technology, additional challenges are being learned. Some of these patients’ diseases are very rare to very, very rare, where the world experience may be very few patients and clinical care is based on much less data and is helped by the courses of similar patients.
My clinical interests have always centered on improving the care and outcomes of allogeneic Hematopoietic Cell Transplantation (HSCT) for all patients in need of an HSCT. As our BMT Team has grown, I am now able to focus on HSCT for children with life-threatening Non-Malignant Disorders. Specifically, as a Pediatric Immunologist, I have passion for HSCT to help children born with inherited Primary Immunodeficiency Disorders (PID), which includes all forms of Severe Combined Immunodeficiency Diseases (SCID, Wiskott Aldrich Syndrome, and many more). As well as the more recently recognized PIDs of Immune-Dysregulation (such as IPEX, Gain of Function STAT3, and other even rarer disorders that we are discovering with current gene sequencing techniques). I believe that better understanding the causes of both the Immunodeficiency PIDs and Immune-dysregulation PIDs will result in direct improvement in the outcomes for allogeneic HSCT in each group. My other clinical interests are in constantly improving the results for Unrelated Cord Blood Transplantation. Here, I have started with the source and am a Founder and Medical Director of the University of Colorado Cord Blood Bank, one of the largest public CB Banks in the world that has provided life-saving unrelated CB grafts for children and adults in BMT Centers around the world. My other interests include suing the immune system to fight Cancer, improving our knowledge of Blood Cell Biology, and understanding Graft Versus Host Disease, with the goals of better prevention and improved therapy and outcomes should GVHD occur.
Care Philosophy
My clinical philosophy has always been ‘Do the Right Thing for the Patient’. This means striving to provide the absolute best care, starting with diagnosis and throughout treatment, which relies on current and extensive knowledge of the biology and treatment of each of these relatively rare diseases, based on the scientific and medical knowledge, both in the literature and based on direct communication with other experts in the field. I have always believed and have seen repeatedly proven that greater scientific understanding of a disease process and how it harms the patient improves our care and ability to cure that disease. I also believe that recognizing and carefully considering the patient’s specific problems and needs in the context of their disease and its biology, allows for the informed changing or customizing the approach if required. As we define more disease using gene technology, additional challenges are being learned. Some of these patients’ diseases are very rare to very, very rare, where the world experience may be very few patients and clinical care is based on much less data and is helped by the courses of similar patients.
Personal Interests
I am passionate about the outdoors and being in nature! In the winter, alpine skiing is my main outdoor focus. In the summer, it is drives to the remote mountains with hikes in natural settings. While I take nature photos, I am much more likely to grab my binocs or telescope to clearly see that eagle or moose. In town, the near-by drive through the Rocky Mountain Arsenal National Wildlife refuge is a quick dose of nature and some awesome sunsets. Another passion is music at both indoors and outdoor setting, especially Red Rocks.
Volunteer Activities
I have been a founding and active board member of Joseph's Journey, which sends children with life-threatening diseases on an outdoor adventure, such as a camping, hunting, fishing, or horse-back riding trips. We organize and host an annual Fishing Derby (for the last 17 years) for all these kids and their families, all of which I have been an integral participant.
Public Speaking
Yes
I do not often do public speaking any more, but have done so on request, almost always about either Cord Blood Banking or unrelated donor recruiting or retention.
I am passionate about the outdoors and being in nature! In the winter, alpine skiing is my main outdoor focus. In the summer, it is drives to the remote mountains with hikes in natural settings. While I take nature photos, I am much more likely to grab my binocs or telescope to clearly see that eagle or moose. In town, the near-by drive through the Rocky Mountain Arsenal National Wildlife refuge is a quick dose of nature and some awesome sunsets. Another passion is music at both indoors and outdoor setting, especially Red Rocks.
Volunteer Activities
I have been a founding and active board member of Joseph's Journey, which sends children with life-threatening diseases on an outdoor adventure, such as a camping, hunting, fishing, or horse-back riding trips. We organize and host an annual Fishing Derby (for the last 17 years) for all these kids and their families, all of which I have been an integral participant.
Public Speaking
Yes
I do not often do public speaking any more, but have done so on request, almost always about either Cord Blood Banking or unrelated donor recruiting or retention.