Tom Henthorn, MD
Professor, Anesthesiology

Teaching

Publications

• Dahan A, Olofsen E, Henthorn TK, van Velzen M, Niesters M. Ketamine Pharmacodynamics Entangled: Reply. Anesthesiology. 2022 Sep 9. [Epub ahead of print] PubMed PMID: 36095056
• Dahan A, Henthorn TK. Editorial: Ketamine for treatment of acute and chronic pain: The relationship of mechanism and exposure to therapeutic outcome. Front Pain Res (Lausanne). 2022;3:991569. PubMed PMID: 36081983
• Sempio C, Huestis MA, Kaplan B, Klawitter J, Christians U, Henthorn TK. Urinary clearance of 11-nor-9-carboxy-?(9) -tetrahydrocannabinol: A detailed pharmacokinetic analysis. Drug Test Anal. 2022 Aug;14(8):1368-1376. PubMed PMID: 35332698
• Olofsen E, Kamp J, Henthorn TK, van Velzen M, Niesters M, Sarton E, Dahan A. Ketamine Psychedelic and Antinociceptive Effects Are Connected. Anesthesiology. 2022 May 1;136(5):792-801. PubMed PMID: 35188952
• Henthorn TK, Krejcie TC, Avram MJ. Elimination Clearance of Dexmedetomidine: Cross-examining What the Data Say. Anesthesiology. 2022 Feb 1;136(2):258-260. PubMed PMID: 34965290
• Editorial: Ketamine for treatment of acute and chronic pain: The relationship of mechanism and exposure to therapeutic outcome. Front Pain Res (Lausanne). 2022 Aug 23;3:991569. doi: 0.3389/fpain.2022.991569
• Meissner K, Henthorn TK. How relevant is stereoselectivity to the side-effects of ketamine?. Br J Anaesth. 2021 Jul;127(1):1-2. PubMed PMID: 33965204
• Sempio C, Bidwell LC, Hutchison K, Huestis MA, Klawitter J, Christians U, Henthorn TK. Using Population Pharmacokinetic Modeling to Estimate Exposure to ?9-Tetrahydrocannabinol in an Observational Study of Cannabis Smokers in Colorado. Ther Drug Monit. 2021 Aug 1;43(4):536-545. PubMed PMID: 33656464
• Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2021 Aug 14;45(7):686-692. PubMed PMID: 33002141
• Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma ?9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration. Br J Clin Pharmacol. 2020 Mar;86(3):611-619. PubMed PMID: 31747464
• Christians U, Henthorn TK, Walson PD, Oellerich M, Eliasson E. In Memoriam: Professor Folke Sjöqvist. Ther Drug Monit. 2020 Apr 15. [Epub ahead of print] PubMed PMID: 32304489
• Kamp J, Olofsen E, Henthorn TK, van Velzen M, Niesters M, Dahan A. Ketamine Pharmacokinetics. Anesthesiology. 2020 Sep 30. [Epub ahead of print] PubMed PMID: 32997732
• Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2020 Oct 2. [Epub ahead of print] PubMed PMID: 33002141
• Kamp J, Olofsen E, Henthorn TK, van Velzen M, Niesters M, Dahan A. Ketamine Pharmacokinetics. Anesthesiology. 2020 Dec 1;133(6):1192-1213. PubMed PMID: 32997732
• Christians U, Henthorn TK, Walson PD, Oellerich M, Eliasson E. In Memoriam: Professor Folke Sjöqvist. Ther Drug Monit. 2020 Jun;42(3):353. PubMed PMID: 32304489
• Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma ?9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration. Br J Clin Pharmacol. 2020 Mar;86(3):611-619. PubMed PMID: 31747464
• Brooks Peterson M, Cohen MN, O'Neill BR, Garg S, Child J, Henthorn TK, Galinkin JG. Preoperative Vancomycin Administration for Surgical Site Prophylaxis: Plasma and Soft-Tissue Concentrations in Pediatric Neurosurgical and Orthopedic Patients. Anesth Analg. 2020 May;130(5):1435-1444. PubMed PMID: 31397701
• Doufas AG, Shafer SL, Henthorn TK. Opioid-induced Ventilatory Depression in Sleep Apnea: Reply. Anesthesiology. 2019 Oct;131(4):937-938. PubMed PMID: 31403499
• Peterson MB, Cohen MN, O'Neill BR, Garg S, Child J, Henthorn TK, Galinkin JG. Preoperative Vancomycin Administration for Surgical Site Prophylaxis: Plasma and Soft-Tissue Concentrations in Pediatric Neurosurgical and Orthopedic Patients. Anesth Analg. 2019 Aug 6. [Epub ahead of print] PubMed PMID: 31397701
• Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ß-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. J Inherit Metab Dis. 2019 May;42(3):424-437. PubMed PMID: 30873612
• Henthorn TK, Olofsen E. Where's the Beef?: How Much Can We Skimp on Pharmacokinetic-Pharmacodynamic Data?. Anesthesiology. 2019 Feb;130(2):186-188. PubMed PMID: 30589650
• Henthorn TK, Avram MJ, Dahan A, Gustafsson LL, Persson J, Krejcie TC, Olofsen E. Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S( ) and R(-) Ketamine Concentrations. Anesthesiology. 2018 Aug;129(2):260-270. PubMed PMID: 29771709
• Henthorn TK, Mikulich-Gilbertson SK. µ-Opioid Receptor Agonists: Do They Have Utility in the Treatment of Acute Pain?. Anesthesiology. 2018 May;128(5):867-870. PubMed PMID: 29543630
• Jonkman K, Duma A, Olofsen E, Henthorn T, van Velzen M, Mooren R, Siebers L, van den Beukel J, Aarts L, Niesters M, Dahan A. Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers. Anesthesiology. 2017 Oct;127(4):675-683. PubMed PMID: 28759464
• Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Oct;39(5):556-564. PubMed PMID: 28640062