Michael Graner, PhD

Professional Titles

• Professor
• Research Director Neurosurgery Neural Tissue Bank
• Co-Director Exosome Research Core

Recognitions

• Fellow, Cell Stress Society International (2018)
• Award Speaker, Phi Beta Kappa Annual Banquet, Illinois College Epsilon Chapter (2015)
• Best Presentation, International Congress on Hyperthermic Oncology (2016)
• Immediate Past President, Society for Thermal Medicine (2019)
• President, Society for Thermal Medicine (2018)
• Vice President, Society for Thermal Medicine (2017)
• Vice President-Elect, Society for Thermal Medicine (2016)

Research Interests

Publications

• Graner, MW . Brain Tumor Exosomes and Microvesicles: Pleiotropic Effects from Tiny Cellular Surrogates. In “Molecular Targets of CNS Tumors” ISBN 978-953-307-736-9. M Garami, editor. InTech Open Access Publisher http://www.intechopen.com/articles/show/title/brain-tumor-exosomes-and-microvesicles-pleiotropic-effects-from-tiny-cellular-surrogates
• Epple LM, Griffiths SG, Dechkovskaia AM, White J, Ouellette RJ, Anchodoquy TJ, Bemis LT and Graner MW. Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles. PLoS ONE in revision
• Zhang M, Zheng X, Zhang J, Zhu Y, Zhu X, Liu H, Graner MW, Zhou B, Chen X. CD19+CD1d+CD5+ B Cell Frequencies Are Increased in Patients with Tuberculosis and Suppress Th17 Responses. In press, Cellular Immunology
• Qiu Z, Zhang, M, Zhu Y, Zheng F, Lu P, Liu L, Graner MW, Zhou B, Chen X. Multifunctional CD4 T Cell Responses in Patients with Active Tuberculosis. Science Reports. 2012. 2:216.
• Zhang M, Zheng X, Zhang J, Zhu Y, Zhu X, Liu H, Graner MW, Zhou B, Chen X. CD19+CD1d+CD5+ B Cell Frequencies Are Increased in Patients with Tuberculosis and Suppress Th17 Responses. Cellular Immunology. 2012. 274(1-2): 89-97
• Epple LM, Griffiths SG, Dechkovskaia AM, Dusto NL, White J, Ouellette RJ, Anchodoquy TJ, Bemis LT and Graner MW. Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles. PLoS ONE, 2012. 7(7):e42064
• Epple LM, Bemis LT, Cavanagh R, Skope A, Sonnenfeld T, Frank C, Olver CS, Lencioni AM, Dusto NL, Tal A, Har-Noy M, Katsanis E, Lillehei KO, Graner MW. Prolonged remission of advanced bronchoalveolar adenocarcinoma in a dog treated with autologous, tumor-derived chaperone-rich cell lysate (CRCL) vaccine In press, International Journal of Hyperthermia
• Graner MW, Romanoski A, and E Katsanis Peptidomics and proteomics of chaperone-rich cell lysate vaccines and antigens. In press, International Journal of Hyperthermia
• Mayer-Sonnenfeld T, Har-Noy M, Lillehei KO, and Graner MW. Proteomic analyses of different human tumor-derived chaperone-rich cell lysate (CRCL) anti-cancer vaccines reveal antigen content and strong similarities amongst the vaccines along with a basis for CRCL’s unique structure. In press, International Journal of Hyperthermia
• Graner MW, Epple LM, Dusto NL, Lencioni AM, Nega M, Herring M, Winston B, Madsen H, Bemis LT, Anchordoquy TJ. Circulating exosomes as new biomarkers for brain disease and injury. In press, Proceedings of SPIE
• Marshall D, Mitchell DA, Graner MW*, Bigner DD. Immunotherapy of Brain Tumors. 2012. 104:309-30. In “Handbook of Clinical Neurology: Neuro-Oncology”, W Grisold and R Soffietti, eds, Elsevier, UK. (*corresponding author)
• Ramteke A, Ting H, Agarwal C, Mateen S, Somasagara R, Hussain A, Graner M, Frederick B, Agarwal R, Deep G. Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. Mol Carcinog. 2015 Jul;54(7):554-65. PubMed PMID: 24347249
• Smyth T, Kullberg M, Malik N, Smith-Jones P, Graner MW, Anchordoquy TJ. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J Control Release. 2015 Feb 10;199:145-55. PubMed PMID: 25523519
• Yu Y, Jin D, Hu S, Zhang Y, Zheng X, Zheng J, Liao M, Chen X, Graner M, Liu H, Jin Q. A novel tuberculosis antigen identified from human tuberculosis granulomas. Mol Cell Proteomics. 2015 Apr;14(4):1093-103. PubMed PMID: 25605460
• Graner MW, Lillehei KO, Katsanis E. Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines. Front Oncol. 2014;4:379. PubMed PMID: 25610811
• Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Line A, Lipps G, Llorente A, Lötvall J, Mancek-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4:27066. PubMed PMID: 25979354
• Schlaepfer IR, Nambiar DK, Ramteke A, Kumar R, Dhar D, Agarwal C, Bergman B, Graner M, Maroni P, Singh RP, Agarwal R, Deep G. Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation. Oncotarget. 2015 Sep 8;6(26):22836-56. PubMed PMID: 26087400
• Hellwinkel JE, Redzic JS, Harland TA, Gunaydin D, Anchordoquy TJ, Graner MW. Glioma-derived extracellular vesicles selectively suppress immune responses. Neuro Oncol. 2015 Sep 18. [Epub ahead of print] PubMed PMID: 26385614
• Kunigelis KE, Graner MW. The Dichotomy of Tumor Exosomes (TEX) in Cancer Immunity: Is It All in the ConTEXt?. Vaccines (Basel). 2015 Dec 17;3(4):1019-51. PubMed PMID: 26694473
• The Unfolded Protein Response (UPR) in Glioblastomas: Targetable or Trouble? Invited Review, Future Science OA, (2015) FSO45, eISSN 2056-5623, 28 July 2015 http://www.future-science.com/doi/full/10.4155/fso.15.45
• Contreras-Zárate MJ, Ormond DR, Gillen AE, Hanna C, Day NL, Serkova NJ, Jacobsen BM, Edgerton SM, Thor AD, Borges VF, Lillehei KO, Graner MW, Kabos P, Cittelly DM. Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases. Front Oncol. 2017;7:252. PubMed PMID: 29164052
• Oushy S, Hellwinkel JE, Wang M, Nguyen GJ, Gunaydin D, Harland TA, Anchordoquy TJ, Graner MW. Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737). PubMed PMID: 29158308
• Beseler C, Vollmer T, Graner M, Yu X. The complex relationship between oligoclonal bands, lymphocytes in the cerebrospinal fluid, and immunoglobulin G antibodies in multiple sclerosis: Indication of serum contribution. PLoS One. 2017;12(10):e0186842. PubMed PMID: 29059249
• Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20;9(408). PubMed PMID: 28931657
• Zhou K, Spillman MA, Behbakht K, Komatsu JM, Abrahante JE, Hicks D, Schotl B, Odean E, Jones KL, Graner MW, Bemis LT. A method for extracting and characterizing RNA from urine: For downstream PCR and RNAseq analysis. Anal Biochem. 2017 Nov 1;536:8-15. PubMed PMID: 28803886
• Betker JL, Angle BM, Graner MW, Anchordoquy TJ. The Potential of Exosomes From Cow Milk for Oral Delivery. J Pharm Sci. 2018 Nov 20. [Epub ahead of print] PubMed PMID: 30468828
• HSP90 and Immune Modulation in Cancer. Invited Review, Advances in Cancer Research, In Press http://www.sciencedirect.com/science/article/pii/S0065230X15000962
• Graner MW. Extracellular vesicles in cancer immune responses: roles of purinergic receptors. Semin Immunopathol. 2018 Sep 12. [Epub ahead of print] PubMed PMID: 30209547
• Graner MW, Schnell S, Olin MR. Tumor-derived exosomes, microRNAs, and cancer immune suppression. Semin Immunopathol. 2018 Sep;40(5):505-515. PubMed PMID: 29869058
• Oushy S, Hellwinkel JE, Wang M, Nguyen GJ, Gunaydin D, Harland TA, Anchordoquy TJ, Graner MW. Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737). PubMed PMID: 29158308
• 5. Graner MW. B Cell Exosomes / Extracellular Vesicles as Vehicles of B Cell Antigen Presentation: Implications for Cancer Vaccine Therapies. 2018. In “Diagnostic and Therapeutic Applications of Exosomes in Cancer” 1st Edition. Edited By Drs. Mansoor M. Amiji and Rajagopal Ramesh. Elsevier; Academic Press
• Graner MW. Roles of Extracellular Vesicles in High-Grade Gliomas: Tiny Particles with Outsized Influence. Annu Rev Genomics Hum Genet. 2019 Aug 31;20:331-357. PubMed PMID: 30978305
• Graner M. V-ATPase expression in gliomas-Not your grandparents' proton pump. EBioMedicine. 2019 Mar;41:13-14. PubMed PMID: 30808578
• Betker JL, Angle BM, Graner MW, Anchordoquy TJ. The Potential of Exosomes From Cow Milk for Oral Delivery. J Pharm Sci. 2019 Apr;108(4):1496-1505. PubMed PMID: 30468828
• Kennedy PGE, Graner MW, Fringuello A, Zhou W, Pointon T, Alquatli K, Bisel S, Langford D, Yu X. Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders. J Neuroimmune Pharmacol. 2022 Jan 6. [Epub ahead of print] PubMed PMID: 34989971
• Fringuello A, Tatman PD, Wroblewski T, Thompson JA, Yu X, Lillehei KO, Kowalski RG, Graner MW. Cytokine-Laden Extracellular Vesicles Predict Patient Prognosis after Cerebrovascular Accident. Int J Mol Sci. 2021 Jul 22;22(15). PubMed PMID: 34360613
• Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Lillehei K, Youssef AS, Jensen RL, Graner MW, Ormond DR. High-Throughput Mechanistic Screening of Epigenetic Compounds for the Potential Treatment of Meningiomas. J Clin Med. 2021 Jul 16;10(14). PubMed PMID: 34300316
• Kennedy PGE, Graner M, Pointon T, Li X, Tanimoto K, Dennison K, Im G, Fringuello A, Zhou W, Graner A, Sillau S, Vollmer T, Yu X. Aberrant Immunoglobulin G Glycosylation in Multiple Sclerosis. J Neuroimmune Pharmacol. 2021 May 3. [Epub ahead of print] PubMed PMID: 33942224
• Graner MW. Making HSP90 Inhibitors Great Again? Unite for Better Cancer Immunotherapy. Cell Chem Biol. 2021 Feb 18;28(2):118-120. PubMed PMID: 33607004
• Wang Z, Kennedy PG, Dupree C, Wang M, Lee C, Pointon T, Langford TD, Graner MW, Yu X. Antibodies from Multiple Sclerosis Brain Identified Epstein-Barr Virus Nuclear Antigen 1 & 2 Epitopes which Are Recognized by Oligoclonal Bands. J Neuroimmune Pharmacol. 2021 Sep;16(3):567-580. PubMed PMID: 32808238
• Targeting DNA Methyl Transferases with Decitabine in Cultured Meningiomas. Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Lillehei K, Jensen RL Youssef AS, Ormond DR*, Graner MW*. World Neurosurgery 2022 Jun;162:e99-e119. doi: 10.1016/j.wneu.2022.02.108. Epub 2022 Mar 3. PMID: 35248772. * Co-senior author.
• High-throughput screening of epigenetic inhibitors in meningiomas identifies HDAC, G9a, and Jumonji-domain inhibition as potential therapies. Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Lillehei K, Jensen RL Youssef AS, , Graner MW*, Ormond DR*. Journal of Neurological Surgery B – Skull Base. *Co-senior author. IN PRESS
• Glioblastoma extracellular vesicle specific peptides inhibit EV-induced neuronal cytotoxicity. Zhou W, Craft J, Ojemann A, Bergen L, Graner A, Gonzales A, He Q, Kopper T, Smith M, Graner MW*, Yu X*. *Co-senior author. International Journal of Molecular Sciences Jun 28;23(13):7200. doi: 10.3390/ijms23137200 PMID: 35806205
• Phenotype and neuronal cytotoxic function of glioblastoma extracellular vesicles. Zhou W, Lovasz D, Zizzo Z, He Q, Coughlan C, Kowalski RG, Kennedy PGE, Graner A, Lillehei KO, Ormond DR, Youssef AS, Graner MW*, Yu X* * Co-senior author. Biomedicines. 2022 Oct 27;10(11):2718. doi: 10.3390/biomedicines10112718. PMID: 36359238
• Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit. Kowalski RG, Ledreux A, Violette JE, Neumann RT, Ornelas D, Yu X, Griffiths SG, Lewis S, Nash P, Monte AA, Coughlan CM, Deighan C, *Grotta JC, *Jones WJ, *Graner MW *Co-senior authors. Stroke IN PRESS
• Zhou W, Lovasz D, Zizzo Z, He Q, Coughlan C, Kowalski RG, Kennedy PGE, Graner AN, Lillehei KO, Ormond DR, Youssef AS, Graner MW, Yu X. Phenotype and Neuronal Cytotoxic Function of Glioblastoma Extracellular Vesicles. Biomedicines. 2022 Oct 27;10(11). PubMed PMID: 36359238
• Zhou W, Craft J, Ojemann A, Bergen L, Graner A, Gonzales A, He Q, Kopper T, Smith M, Graner MW, Yu X. Glioblastoma Extracellular Vesicle-Specific Peptides Inhibit EV-Induced Neuronal Cytotoxicity. Int J Mol Sci. 2022 Jun 28;23(13). PubMed PMID: 35806205
• Uphaus T, Audebert HJ, Graner MW, Tiedt S, Kowalski RG. Editorial: Blood-Based Biomarkers in Acute Ischemic Stroke and Hemorrhagic Stroke. Front Neurol. 2022;13:866166. PubMed PMID: 35280278
• Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Lillehei KO, Jensen RL, Youssef AS, Ormond DR, Graner MW. Targeting DNA Methyl Transferases with Decitabine in Cultured Meningiomas. World Neurosurg. 2022 Jun;162:e99-e119. PubMed PMID: 35248772
• Kennedy PGE, Graner MW, Fringuello A, Zhou W, Pointon T, Alquatli K, Bisel S, Langford D, Yu X. Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders. J Neuroimmune Pharmacol. 2022 Dec;17(3-4):526-537. PubMed PMID: 34989971
• Kennedy PGE, Graner M, Pointon T, Li X, Tanimoto K, Dennison K, Im G, Fringuello A, Zhou W, Graner A, Sillau S, Vollmer T, Yu X. Aberrant Immunoglobulin G Glycosylation in Multiple Sclerosis. J Neuroimmune Pharmacol. 2022 Jun;17(1-2):218-227. PubMed PMID: 33942224
• Russell AE, Sil S, Buch S, Graner MW. A Report on ASIC2021. Extracellular Vesicles and Circulating RNA (EVCNA) Extracell Vesicles Circ Nucleic Acids 2022;3:232-46. DOI: 10.20517/evcna.2022.31 Published on: 29 Aug 2022
• Russell AE, Graner MW, Buch S. Conference report for the 2nd annual American Society for Intercellular Communication (ASIC) meeting, 2022. Extracell Vesicles Circ Nucl Acids. 2023 Sep;4(3):323-337. PubMed PMID: 37829292
• Zhou W, Graner M, Beseler C, Domashevich T, Selva S, Webster G, Ledreux A, Zizzo Z, Lundt M, Alvarez E, Yu X. Plasma IgG aggregates as biomarkers for multiple sclerosis. Clin Immunol. 2023 Nov;256:109801. PubMed PMID: 37816415
• Kopper TJ, Yu X, Graner MW. Immunopathology of Extracellular Vesicles in Macrophage and Glioma Cross-Talk. J Clin Med. 2023 May 12;12(10). PubMed PMID: 37240536
• Zhou W, Graner M, Paucek P, Beseler C, Boisen M, Bubak A, Asturias F, George W, Graner A, Ormond D, Vollmer T, Alvarez E, Yu X. Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosis. Cell Death Dis. 2023 Apr 8;14(4):254. PubMed PMID: 37031195
• Kowalski RG, Ledreux A, Violette JE, Neumann RT, Ornelas D, Yu X, Griffiths SG, Lewis S, Nash P, Monte AA, Coughlan CM, Deighan C, Grotta JC, Jones WJ, Graner MW. Rapid Activation of Neuroinflammation in Stroke: Plasma and Extracellular Vesicles Obtained on a Mobile Stroke Unit. Stroke. 2023 Mar;54(3):e52-e57. PubMed PMID: 36727508
• Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Youssef AS, Lillehei KO, Jensen RL, Graner MW, Ormond DR. High-Throughput Screening of Epigenetic Inhibitors in Meningiomas Identifies HDAC, G9a, and Jumonji-Domain Inhibition as Potential Therapies. J Neurol Surg B Skull Base. 2023 Oct;84(5):452-462. PubMed PMID: 37671294

Professional Memberships

• American Society for Intercellular Communication, Founding member
• International Society for Extracellular Vesicles, Founding member
• American Society of Exosomes and Microvesicles, Charter member
• Society for Thermal Medicine, Ex-President
• Cell Stress Society International, Fellow
• American Heart Association, member