Pepper Schedin, PhD

Publications

• McDaniel, S., Rumer, K., Biroc, S., Metz, R., Singh, M., Porter, W., and Schedin, P. Remodeling of the mammary microenvironment following lactation promotes breast tumor cell metastasis. American Journal of Pathology, 168 2):608-620, 2006.
• Schedin, P., Pregnancy-associated breast cancer and metastasis. Nature Reviews Cancer, 6:281-291, 2006.
• Rhonda Hattar, Shauntae McDaniel, and Pepper Schedin, Tamoxifen Treatment Functionally Alters the Rat Mammary Stroma Indicating a Role for the ECM in Tumor Suppression, Proceedings, AACR Special Conference in Cancer Research; Cancer, Proteases, and the Tumor Microenvironment, Bonita Springs, FL, Nov 30-Dec 4, 2005.
• Pepper Schedin, Shauntae McDaniel, Sandra Biroc, Meenakshi Singh, K.S. Shailaja, Weston Porter, Richard Metz, and Brittany Allen, Microenvironment of the Involuting Mammary Gland Activates Tumor Angiogenesis and Metastasis, Proceedings, AACR Special Conference in Cancer Research; Cancer, Proteases, and the Tumor Microenvironment, Bonita Springs, FL, Dec 3, 2005.
• Schedin, P., McDaniel, S., Biroc, S., Singh, M., RAj, S., Porter, W., and Metz, R., Microenvironment of the involuting mammary gland activates tumor metastasis: a new target for chemoprevention? Keystone Symposia Proceedings, Molecular Targets for Cancer Prevention, Tahoe City, CA, March 6-10, 2006.
• Elizabeth Tarbutton, E. and Pepper Schedin, Effect of Vitamin A Intake During Adolescence on Susceptibility to MNU-induced Mammary Carcinogenesis in the Adult Sprague-Dawley Rat. Keystone Symposia Proceedings, Molecular Targets for Cancer Prevention, Tahoe City, CA, March 6-10, 2006.
• McDaniel, S., Rumer, K., Biroc, S., Metz, R., Singh, M., Porter, W., and Schedin, P. Remodeling of the mammary microenvironment following lactation promotes breast tumor cell metastasis. American Journal of Pathology, 168 2):608-620, 2006.
• Schedin, P., Pregnancy-associated breast cancer and metastasis. Nature Reviews Cancer, 6:281-291, 2006
• Fornetti J, Jindal S, Middleton KA, Borges VF, Schedin P. Physiological COX-2 Expression in Breast Epithelium Associates with COX-2 Levels in Ductal Carcinoma in Situ and Invasive Breast Cancer in Young Women. Am J Pathol. 2014 Feb 8. [Epub ahead of print] PubMed PMID: 24518566
• Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y. Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. Elife. 2013 Dec 31;2:e00996. PubMed PMID: 24381245
• Hyeong-II, K., Gustafson, T., Metz, P., Laffin B., Schedin, P., and Porter, W. Inhibition of breast cancer growth and invasion by Single-minded 2s, Carcinogenesis, Jul 13; [Epub ahead of print], PMID: 16840439, 2006
• Jacob A, Jing J, Lee J, Schedin P, Gilbert SM, Peden AA, Junutula JR, Prekeris R. Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells. J Cell Sci. 2013 Oct 15;126(Pt 20):4647-58. PubMed PMID: 23902685
• 20. Schedin, P., O’Brien, J., Rudolf, M., Stein, T., and V. Borges, The Microenvironment of the Involuting Mammary Gland Mediates Mammary Cancer Progression. Journal of Mammary gland Biology and Neoplasia, {Epub anead of print}, 2007
• Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P. Collagen architecture in pregnancy-induced protection from breast cancer. J Cell Sci. 2013 Sep 15;126(Pt 18):4108-10. PubMed PMID: 23843613
• Martinson HA, Lyons TR, Giles ED, Borges VF, Schedin P. Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention. Exp Cell Res. 2013 May 9. [Epub ahead of print] PubMed PMID: 23664839
• McDaniel, S.M., C. O'Neill, Metz ,R., Kaeck, M., Sapuntzakis, M., Heimendinger, J, Wolfe P., Thompson, H., and Schedin, P.A comparison of whole food sources of vitamin A to retinyl palmitate on sexual maturation, mammary gland development and mammary carcinogenesis in the rat. J. Nutrition, in press, 2007
• Callihan EB, Gao D, Jindal S, Lyons TR, Manthey E, Edgerton S, Urquhart A, Schedin P, Borges VF. Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer. Breast Cancer Res Treat. 2013 Apr;138(2):549-59. PubMed PMID: 23430224
• 1. Schedin, P., O’Brien, J., Rudolf, M., Stein, T., and V. Borges, The Microenvironment of the Involuting Mammary Gland Mediates Mammary Cancer Progression. Journal of Mammary gland Biology and Neoplasia, 1415-1472, 2007.
• 1. Brian Laffin, Elizabeth Wellberg, Hyeong-Il Kwak, Robert C. Burghardt, Richard P. Metz,Tanya Gustafson, Pepper Schedin and Weston W. Porter, Loss of Singleminded-2s in the mouse mammary gland induces an epithelial mesenchymal transition associated with up-regulation of Slug and MMP2. Molecular and Cellular Biology, 28:1936-1946, 2008
• 1. Lyons, T.R.*, O’Brien, J.*, Borges, V., Conklin, M.W., Keely, P.J., Elicieri, K.W., Marusyk, A., Tan, A.C., and Schedin, P. Postpartum mammary gland involution drives DCIS progression through collagen and COX-2, Nature Medicine, August 2011; doi:10.1038nm.2416
• 2. O’Brien, J., Hansen, K., Barkan, D., Green, J., and Schedin, P. NSAIDs target pro-tumorigenic extracellular matrix of the postpartum mammary gland, Int J Dev Biol, 2011;55(7-9):745-55.
• 3. Shim YJ, Kang BH, Jeon HS, Park IS, Lee KU, Lee IK, Park GH, Lee KM, Schedin P, Min BH. Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-?B pathways in monocytes/macrophages. J Leukoc Biol, 2011 Oct;90(4):761-9.
• Harvell DM, Kim J, O'Brien J, Tan AC, Borges VF, Schedin P, Jacobsen BM, Horwitz KB. Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Horm Cancer. 2013 Jun;4(3):140-53. PubMed PMID: 23479404
• 4. O’Brien, J., Martinson, H., Durand-Rougely C and Schedin, P. Macrophages are critical for epithelial cell apoptosis and adipocyte repopulation during mammary gland involution, Development, 2012 Jan;139(2):269-75.
• 7. Robert A. Ramirez, Amy Lee, Pepper Schedin, Joshua S. Russell, and Patricia, A. Masso-Welch, Alterations in mast cell frequency and relationship to angiogenesis 1 in the rat mammary gland during windows of physiologic tissue remodeling, Developmental Dynamics, in press, 2012.
• 5. Schedin, P. and Borges, V., Pregnancy Associated Breast Cancer: an entity in need of refining the definition, Cancer, 2011 Nov 15. doi: 10.1002/cncr.26643. [Epub ahead of print]
• 6. Jaime Fornetti, Holly Martinson, Virginia Borges, Pepper Schedin. Emerging targets for the prevention of pregnancy-associated breast cancer, Cell Cycle, 11:4, 639-640; February 15, 2012.
• 1) Ramirez RA, Lee A, Schedin P, Russell JS, Masso-Welch PA. Alterations in mast cell frequency and relationship to angiogenesis in the rat mammary gland during windows of physiologic tissue remodeling. Dev Dyn. 2012 May;241(5):890-900. doi: 10.1002/dvdy.23778
• Borges V and Schedin P. Could NSAIDs become a preventive therapy in pregnancy-associated breast cancer? Breast Cancer Manage, (2012) 1(1), 39-46.
• 3) O'Brien JH, Vanderlinden LA, Schedin PJ*, Hansen KC. Rat Mammary Extracellular Matrix Composition and Response to Ibuprofen Treatment During Postpartum Involution by Differential GeLC-MS/MS Analysis. *Correspondign Author. J. Proteome Res. 2012 Aug 16. [Epub ahead of print] PMID:22897585
• Giovanna I. Cruz, Maria Elena Martinez, Loki Natarajan, Betsy C. Wertheim, Manuela Gago-Dominguez, Melissa Bondy, Adrian Daneri-Navarro, Mari´a Mercedes Meza-Montenegro, Luis Enrique Gutierrez-Millan, Abenaa Brewster, Pepper Schedin, Ian K. Komenaka, J. Esteban Castelao, Angel Carracedo, Carmen M. Redondo and Patricia A. Thompson. Hypothesized role of pregnancy hormones on HER2+ breast tumor development. Breast Cancer Res Treat, Oct 24, 2012, DOI 10.1007/s10549-012-2313-0
• Erin D. Giles, Elizabeth A. Wellberg, David P. Astling, Steven M. Anderson, Ann D. Thor, Sonali Jindal, Aik-Choon Tan, Pepper Schedin, and Paul S. MacLean. Obesity and Overfeeding Affecting Both Tumor and Systemic Metabolism Activates the Progesterone Receptor to Contribute to Postmenopausal Breast Cancer, Cancer Research, December 7, 2012; DOI:10.1158/0008-5472.CAN-12-1653
• Faupel-Badger JM, Arcaro KF, Balkam JJ, Eliassen AH, Hassiotou F, Lebrilla CB, Michels KB, Palmer JR, Schedin P, Stuebe AM, Watson CJ, Sherman ME. Postpartum Remodeling, Lactation and Breast Cancer Risk: Summary of a National Cancer Institute Sponsored Workshop, JNCI, Accepted 10-2012 J Natl Cancer Inst. 2012 Dec 21. [Epub ahead of print] PMID:23264680
• Eryn B. Callihan, Dexiang Gao, Sonali Jindal, Traci R Lyons, Elizabeth Manthey, Susan Edgerton, Alexander Urquhart, Pepper Schedin, and Virginia F. Borges, Postpartum Diagnosis Demonstrates a High Risk for Metastasis and Merits an Expanded Definition of Pregnancy-Associated Breast Cancer, Breast Cancer Res Treat. 2013 Apr;138(2):549-59. doi: 10.1007/s10549-013-2437-x. Epub 2013 Feb 22
• Djuana M E. Harvell, Jihye Kim, Jenean O’Brien, Aik-Choon Tan, Virginia F. Borges, Pepper Schedin, Britta M. Jacobsen, and Kathryn B. Horwitz, Genomic Signatures of Pregnancy-Associated Breast Cancer Epithelia and Stroma and their Regulation by Estrogens and Progesterone, Hormones and Cancer, 2013 Mar. 12 (Epub ahead of print)