John Corboy, MD, MA
Professor, Neurology

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Medical School:
  • MD, University of Pennsylvania School of Medicine (1985)
Graduate School :
  • MA, University of California, Los Angeles (1978)
Undergraduate School:
  • BA, University of Pennsylvania (Philadelphia, PA) (1976)
Internship:
  • University of Pennsylvania Program (1986)
Residency:
  • University of Pennsylvania Health System Program, Chief Resident, Psychiatry (1989)
Fellowships:
  • Johns Hopkins University Program, Neurovirology (1992)
Languages: English
Department: Neurology

Professional Titles

  • Charles Elliot Morris Chair in Neurology
  • Executive Vice Chair of Neurology
  • Co-Director, Rocky Mountain Multiple Sclerosis Center at Anschutz Medical Campus
  • Director, Neuroimmunology/MS Fellowship
  • Section Chief, Neuroimmunology

Research Interests

Clinical research in MS and related disorders

Teaching

  • Professor (1994)
    School of Medicine, Neurology
    Multiple sclerosis, Neuroimmunology

Publications

  • Barrera B, Simpson H, Engebretson E, Sillau S, Valdez B, Parra-González J, Winger RC, Epperson LA, Banks A, Pierce K, Spotts M, O'Gean K, Alvarez E, Gross R, Piquet AL, Schreiner T, Corboy JR, Pei J, Vollmer TL, Nair KV. Safety and patient experience with at-home infusion of ocrelizumab for multiple sclerosis. Ann Clin Transl Neurol. 2023 Apr;10(4):579-588. doi: 10.1002/acn3.51745. Epub 2023 Feb 22.PMID: 36811392
  • Corboy JR, Fox RJ, Kister I, Cutter GR, Morgan CJ, Seale R, Engebretson E, Gustafson T, Miller AE. Risk of new disease activity in patients with multiple sclerosis who continue or discontinue disease-modifying therapies (DISCOMS): a multicentre, randomised, single-blind, phase 4, non-inferiority trial. Lancet Neurol. 2023 Jul;22(7):568-577. doi: 10.1016/S1474-4422(23)00154-0.PMID: 37353277
  • Shafit-Zagardo B, Sidoli S, Goldman JE, DuBois JC, Corboy JR, Strittmatter SM, Guzik H, Edema U, Arackal AG, Botbol YM, Merheb E, Nagra RM, Graff S. TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury. Cells. 2023 Jun 27;12(13):1734. doi: 10.3390/cells12131734.PMID: 37443768
  • Solomon AJ, Arrambide G, Brownlee WJ, Flanagan EP, Amato MP, Amezcua L, Banwell BL, Barkhof F, Corboy JR, Correale J, Fujihara K, Graves J, Harnegie MP, Hemmer B, Lechner-Scott J, Marrie RA, Newsome SD, Rocca MA, Royal W 3rd, Waubant EL, Yamout B, Cohen JA. Differential diagnosis of suspected multiple sclerosis: an updated consensus approach. Lancet Neurol. 2023 Aug;22(8):750-768. doi: 10.1016/S1474-4422(23)00148-5.PMID: 37479377
  • Borko TL, Baxter R, Cabrera-Martinez B, Thiruppathi E, Sabalza M, Venkataraman I, Selva S, Rester C, Sillau S, Pastula DM, Bennett JL, Alvarez E, Gross R, Shah A, Kammeyer R, Corboy JR, Kedl RM, Hsieh EWY, Piquet AL. SARS-CoV-2 mRNA vaccination induces an antigen-specific T cell response correlating with plasma interferon-gamma in B cell depleted patients. J Neuroimmunol. 2023 Oct 15;383:578192. doi: 10.1016/j.jneuroim.2023.578192. Epub 2023 Aug 29.PMID: 37666038
  • Abstract 1605 ECTRIMS DISCOntinuation of disease modifying therapies in MS (DISCOMS); Primary results of the extension trial
  • Alvarez E, Nair KV, Sillau S, Shelton I, Seale R, Selva S, Corboy J, Vollmer TL. Tolerability and Safety of Switching from Rituximab to Ocrelizumab: Evaluating Factors Associated with Infusion Related Reactions. Mult Scler J Exp Transl Clin. 2022 Jan-Mar;8(1):20552173211069359. PubMed PMID: 35024160
  • Vollmer BL, Wolf AB, Sillau S, Corboy JR, Alvarez E. Evolution of Disease Modifying Therapy Benefits and Risks: An Argument for De-escalation as a Treatment Paradigm for Patients With Multiple Sclerosis. Front Neurol. 2022 Jan 25;12:799138. doi: 10.3389/fneur.2021.799138. eCollection 2021.PMID: 3514547 85. Shah AA, Wolf AB, Declusin A, Coleman K, Kammeyer R, Khan B, Corboy JR. Challenging Cases in Neuroimmunology. Semin Neurol. 2022 Dec;42(6):695-707. doi: 10.1055/s-0042-1760100. Epub 2023 Jan 23.PMID: 36690027
  • Vollmer BL, Wolf AB, Sillau S, Corboy JR, Alvarez E. Evolution of Disease Modifying Therapy Benefits and Risks: An Argument for De-escalation as a Treatment Paradigm for Patients With Multiple Sclerosis. Front Neurol. 2021;12:799138. PubMed PMID: 35145470
  • Alvarez E, Nair KV, Hoyt BD, Seale RA, Sillau S, Miravalle A, Engebretson E, Schurr B, Corboy JR, Vollmer TL, Honce JM. Brain atrophy rates in patients with multiple sclerosis on long term natalizumab resembles healthy controls. Mult Scler Relat Disord. 2021 Oct;55:103170. PubMed PMID: 34364034
  • Strijbis EMM, Kerbrat A, Corboy JR. Discontinuation of Disease-Modifying Therapy in Multiple Sclerosis: Should We Stay or Should We Go? JAMA Neurol. 2021 Jul 1;78(7):787-788. doi: 10.1001/jamaneurol.2021.0764.PMID: 33871561
  • Alvarez E, Nair KV, Hoyt BD, Seale RA, Sillau S, Miravalle A, Engebretson E, Schurr B, Corboy JR, Vollmer TL, Honce JM. Brain atrophy rates in patients with multiple sclerosis on long term natalizumab resembles healthy controls. Mult Scler Relat Disord. 2021 Jul 24;55:103170. doi: 10.1016/j.msard.2021.103170. Online ahead of print.PMID: 34364034
  • Piquet AL, Corboy JR, Vollmer TL. Correspondence to: Humoral immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis treated with high-efficacy disease-modifying therapies. Ther Adv Neurol Disord. 2021;14:17562864211019567. PubMed PMID: 34104219
  • Corboy JR, Jones EC, Barbano RL, Anderson DC. 2019-2020: A Message From the Editors to Our Reviewers. Neurol Clin Pract. 2021 Feb;11(1):e1-e5. PubMed PMID: 33968478
  • Strijbis EMM, Kerbrat A, Corboy JR. Discontinuation of Disease-Modifying Therapy in Multiple Sclerosis: Should We Stay or Should We Go?. JAMA Neurol. 2021 Jul 1;78(7):787-788. PubMed PMID: 33871561
  • Vollmer BL, Wallach AI, Corboy JR, Dubovskaya K, Alvarez E, Kister I. Serious safety events in rituximab-treated multiple sclerosis and related disorders.Ann Clin Transl Neurol. 2020 Aug 6. doi: 10.1002/acn3.51136. Online ahead of print. PMID: 32767531
  • Vollmer BL, Nair K, Sillau S, Corboy JR, Vollmer T, Alvarez E. Rituximab versus natalizumab, fingolimod, and dimethyl fumarate in multiple sclerosis treatment. Ann Clin Transl Neurol. 2020 Aug 6. doi: 10.1002/acn3.51111. Online ahead of print. PMID: 32767538
  • Cree BAC, Goldman MD, Corboy JR, Singer BA, Fox EJ, Arnold DL, Ford C, Weinstock-Guttman B, Bar-Or A, Mientus S, Sienkiewicz D, Zhang Y, Karan R, Tenenbaum N; Efficacy and Safety of 2 Fingolimod Doses vs Glatiramer Acetate for the Treatment of Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial. ASSESS Trial Investigators. JAMA Neurol. 2020 Aug 24:e202950. doi: 10.1001/jamaneurol.2020.2950. Online ahead of print.PMID: 32852530
  • Wu Q, Mills EA, Wang Q, Dowling CA, Fisher C, Kirch B, Lundy SK, Fox DA, Mao- Draayer Y. Siponimod enriches regulatory T and B lymphocytes in secondary progressive multiple sclerosis.; AMS04 Study Group.JCI Insight. 2020 Feb 13;5(3). pii: 134251. doi: 10.1172/jci.insight.134251. PMID: 31935197
  • Cree BAC, Cutter G, Wolinsky JS, et al SPI2 investigative teams. Safetyand efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol. 2020 Dec;19(12):988-997. doi: 10.1016/S1474-4422(20)30347-1. Epub 2020 Oct 23.PMID: 33222767
  • Cree BAC, Goldman MD, Corboy JR, Singer BA, Fox EJ, Arnold DL, Ford C, Weinstock-Guttman B, Bar-Or A, Mientus S, Sienkiewicz D, Zhang Y, Karan R, Tenenbaum N; Efficacy and Safety of 2 Fingolimod Doses vs Glatiramer Acetate for the Treatment of Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial. ASSESS Trial Investigators. JAMA Neurol. 2020 Aug 24; 78(1):1-13. doi: 10.1001/jamaneurol.2020.2950. Online ahead of print. PMID: 32852530
  • Honce JM, Nair KV, Hoyt BD, Seale RA, Sillau S, Engebretson E, Schurr B, Corboy JR, Vollmer TL, Alvarez E. Brain Atrophy Rates for Stable Multiple Sclerosis Patients on Long-Term Fingolimod versus Glatiramer Acetate. Front Neurol. 2020 Sep 23;11:1045. doi: 10.3389/fneur.2020.01045. eCollection 2020.PMID: 33071934
  • Waid DM, Schreiner T, Vaitaitis G, Carter JR, Corboy JR, Wagner DH Jr. Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells. J Neuroimmunol. 2014 Mar 15. [Epub ahead of print] PubMed PMID: 24690203
  • Lafosse JM, Mitchell SM, Corboy JR, Filley CM. The nature of verbal memory impairment in multiple sclerosis: a list-learning and meta-analytic study. J Int Neuropsychol Soc. 2013 Oct;19(9):995-1008. PubMed PMID: 24059259
  • Mattson DH, Lisak RP, Jones DE, Corboy JR, Larson R, Gronseth G, Getchius TS, Langer-Gould A, Langer-Gould AM, Gronseth GS, Larson R, Getchius TS. The American Academy of Neurology's top five Choosing Wisely recommendations. Neurology. 2013 Sep 10;81(11):1022-3. PubMed PMID: 24019388
  • Campbell JD, McQueen RB, Miravalle A, Corboy JR, Vollmer TL, Nair K. Comparative effectiveness of early natalizumab treatment in JC virus-negative relapsing-remitting multiple sclerosis. Am J Manag Care. 2013 Apr;19(4):278-85. PubMed PMID: 23725360
  • Hebert JR, Corboy JR. The association between multiple sclerosis-related fatigue and balance as a function of central sensory integration. Gait Posture. 2013 May;38(1):37-42. PubMed PMID: 23200463
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Professional Memberships

  • American Neurological Association, Elected Member
  • Colorado Society of Clinical Neurologists, 1995-1997 Secretary/Treasurer
  • American Academy of Neurology, Fellow 2003

Practice Locations

UCHealth Neurosciences Center - Anschutz Medical Campus
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Neurology, Board Certification (1990)
  • Neuroimmunology
Conditions & Treatments
  • Brain and Nervous System
  • Brain and Nervous System - Multiple Sclerosis
Clinical Interests
Multiple Sclerosis, other neuroimmunological disorders, HIV in Nervous System, Infections and Inflammatory Disorders of the Central Nervous System

Care Philosophy
Multidisciplinary care for MS and related diseases. We believe in aggressive treatment of MS with disease modifying and symptomatic therapies.

Personal Interests
Skiing, golf, ice hockey, travel.

Volunteer Activities
Board member, National MS Society, Colorado-Wyoming Chapter Volunteer MS clinic at Denver Health Medical Center Advocacy at State and National level for access to health care

Public Speaking
Yes
MS Education at multiple levels

General Information

Medical Schools:
  • MD, University of Pennsylvania School of Medicine (1985)
Graduate Schools:
  • MA, University of California, Los Angeles (1978)
Undergraduate Schools:
  • BA, University of Pennsylvania (Philadelphia, PA) (1976)
Internships:
  • University of Pennsylvania Program (1986)
Residency Programs:
  • University of Pennsylvania Health System Program, Chief Resident, Psychiatry (1989)
Fellowships:
  • Johns Hopkins University Program, Neurovirology (1992)
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Languages: English
Department: Neurology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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