John Sladek, PhD

Publications

• Sladek, J. R., Jr. and K. B. Bjugstad. 2011. The future of stem cell applications: charting the sea of opportunity. Journal of Innovation and Technology. (in press).
• Kern D.S., Maclean K.N. Jiang H., Snyder E.Y, Sladek J.R. Jr., Bjugstad K.B. 2011. Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell Transplantation (in press)
• Redmond, D.E. Jr, S.Weiss, J.D. Elsworth, R.H. Roth, D.R. Wakeman, K.B. Bjugstad ,T.J. Collier, B.C. Blanchard, Y.D. Teng, E.Y. Snyder, and J.R. Sladek Jr. 2010. Cellular repair in the parkinsonian non-human primate brain. Rejuvination Research 13:188-194.
• Liu X, Li F, Stubblefield E A, Blanchard B, Richards T L, Larson G A, He Y , Huang Q , Tan A-C, Zhang D, Benke T.A, Sladek J.R., Zahniser N.R., Li C-Y; Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells; Cell Research 1-12 (2011); In print Nov. 2011.
• Redmond, D.E. Jr, C. R.S. McEntire, J P. Kingsbery, C Leranth, J D. Elsworth, K B. Bjugstad, R H. Roth, R J. Samulski, J R. Sladek, Jr. Comparison of fetal mesencephalic grafts, AAV-delivered GDNF and both combined in an MPTP-induced non human primate Parkinson’s model. Molecular Therapy 12:2160-2168. 2013
• Kern D.S., Maclean K.N., Jiang H., Snyder E.Y, Sladek J.R. Jr., Bjugstad K.B. 2011. Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell Transplantation 20:371-379.
• Wakeman, D.R., Weiss, S., Sladek. J.R., Elsworth, J.D., Bauereis, B., Leranth, C., Hurley, P.J., Roth, R.H. and D.E.Redmond Jr. Survival and integration of dopamine neurons derived from human embryonic stem cells in MPTP-lesioned primate. Cell Transplantation 8:981-984. 2014
• Wakeman, D., Redmond, D.E., Dodiya, H., Sladek, J. R. Jr, Leranth. C., Teng, Y., Samulski, J., and E. Y. Snyder. Human neural stem cells survive long term in midbrain of dopamine-depleted monkeys after GDNF over-expression and project neurites toward an approriate target. Stem Cells Translational Medicine. 6: 692-701, 2014.
• A. L. Rachubinski, S K. Crowley, J R. Sladek, Jr., K. N. Maclean, K. B. Bjugstad, The effects of neonatal neural progenitor cell implantation on adult neuroanatomy and cognition in the Ts65Dn model of Down syndrome. PloS One. in press 2012
• Rachubinski A.L., Crowley S.K., Sladek, J.R.JR., Maclean K.N., and Bjugstad K.B. The effects of neonatal neural progenitor cell implantation on adult neuroanatomy and cognition in the Ts65Dn model of Down syndrome. PloS ONE 7(4):e36082. 2012.
• Sladek, J.R. Neural development, a risky period. Exp Neurol 237:43-45. 2012
• Redmond, D.E. Jr, C. R.S. McEntire, J P. Kingsbery, C Leranth, J D. Elsworth, K B. Bjugstad, R H. Roth, R J. Samulski, J R. Sladek, Jr. Fetal ventral mesencephalic transplants and rAAV/GDNF injections, alone or in combination, showed behavioral recovery compared with saline injected Parkinsonian monkeys. Molecular Therapy in press 2013

Practice Locations

Hospital Affiliation

• Children's Hospital Colorado

Center Affiliations

• Center for Neuroscience

Specialty Information

Conditions & Treatments

• Brain and Nervous System