Samuel Dominguez, MD, PhD

Professional Titles

• Professor of Pediatrics

Research Interests

Publications

• Dominguez SR, Anderson MS. Advances in the treatment of Kawasaki disease. Curr Opin Pediatr. 2012 Dec 31. [Epub ahead of print] PubMed PMID: 23283289
• Eladawy M, Dominguez SR, Anderson MS, Glodé MP. Kawasaki Disease Presenting To the Pediatric Gastroenterologist: A Diagnostic Challenge. J Pediatr Gastroenterol Nutr. 2012 Oct 18. [Epub ahead of print] PubMed PMID: 23085893
• Messacar K, Robinson CC, Bagdure D, Curtis DJ, Glodé MP, Dominguez SR. Rhino/enteroviruses in hospitalized children: A comparison to influenza viruses. J Clin Virol. 2013 Jan;56(1):41-5. PubMed PMID: 23078869
• Dominguez SR, Sims GE, Wentworth DE, Halpin RA, Robinson CC, Town CD, Holmes KV. Genomic analysis of 16 Colorado human NL63 coronaviruses identifies a new genotype, high sequence diversity in the N-terminal domain of the spike gene and evidence of recombination. J Gen Virol. 2012 Nov;93(Pt 11):2387-98. PubMed PMID: 22837419
• Dominguez SR, Anderson MS, El-Adawy M, Glodé MP. Preventing coronary artery abnormalities: a need for earlier diagnosis and treatment of kawasaki disease. Pediatr Infect Dis J. 2012 Dec;31(12):1217-20. PubMed PMID: 22760536
• Frost HM, Robinson CC, Dominguez SR. Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1-3. J Infect Dis. 2013 Nov 7. [Epub ahead of print] PubMed PMID: 24133181
• Qian Z, Dominguez SR, Holmes KV. Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation. PLoS One. 2013 Oct 3;8(10):e76469. PubMed PMID: 24098509
• Góes LG, Ruvalcaba SG, Campos AA, Queiroz LH, de Carvalho C, Jerez JA, Durigon EL, Dávalos LI, Dominguez SR. Novel bat coronaviruses, Brazil and Mexico. Emerg Infect Dis. 2013 Oct;19(10):1711-3. PubMed PMID: 24050144
• Dominguez SR, Travanty EA, Qian Z, Mason RJ. Human coronavirus HKU1 infection of primary human type II alveolar epithelial cells: cytopathic effects and innate immune response. PLoS One. 2013;8(7):e70129. PubMed PMID: 23894604
• Maloney JA, Mirsky DM, Messacar K, Dominguez SR, Schreiner T, Stence NV. MRI Findings in Children with Acute Flaccid Paralysis and Cranial Nerve Dysfunction Occurring during the 2014 Enterovirus D68 Outbreak. AJNR Am J Neuroradiol. 2014 Nov 20. [Epub ahead of print] PubMed PMID: 25414005
• Pastula DM, Aliabadi N, Haynes AK, Messacar K, Schreiner T, Maloney J, Dominguez SR, Davizon ES, Leshem E, Fischer M, Nix WA, Oberste MS, Seward J, Feikin D, Miller L, Centers for Disease Control and Prevention (CDC). Acute neurologic illness of unknown etiology in children - Colorado, August-September 2014. MMWR Morb Mortal Wkly Rep. 2014 Oct 10;63(40):901-2. PubMed PMID: 25299607
• Messacar K, Cree-Green M, Lovell M, Anderson MS, Dominguez SR. Severe Neuroinvasive West Nile Virus Infection in a Child with Undiagnosed Addison's Disease. IDCases. 2014;1(3):29-31. PubMed PMID: 25133095
• Messacar K, Robinson CC, Bagdure D, Curtis DJ, Glodé MP, Dominguez SR. Rhino/enteroviruses in hospitalized children: a comparison to influenza viruses. J Clin Virol. 2013 Jan;56(1):41-5. PubMed PMID: 23078869
• Muthuri SG, Venkatesan S, Myles PR, Leonardi-Bee J, Al Khuwaitir TS, Al Mamun A, Anovadiya AP, Azziz-Baumgartner E, Báez C, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borja-Aburto VH, Burgmann H, Cao B, Carratala J, Denholm JT, Dominguez SR, Duarte PA, Dubnov-Raz G, Echavarria M, Fanella S, Gao Z, Gérardin P, Giannella M, Gubbels S, Herberg J, Iglesias AL, Hoger PH, Hu X, Islam QT, Jiménez MF, Kandeel A, Keijzers G, Khalili H, Knight M, Kudo K, Kusznierz G, Kuzman I, Kwan AM, Amine IL, Langenegger E, Lankarani KB, Leo YS, Linko R, Liu P, Madanat F, Mayo-Montero E, McGeer A, Memish Z, Metan G, Mickiene A, Mikic D, Mohn KG, Moradi A, Nymadawa P, Oliva ME, Ozkan M, Parekh D, Paul M, Polack FP, Rath BA, Rodríguez AH, Sarrouf EB, Seale AC, Sertogullarindan B, Siqueira MM, Skret-Magierlo J, Stephan F, Talarek E, Tang JW, To KK, Torres A, Törün SH, Tran D, Uyeki TM, Van Zwol A, Vaudry W, Vidmar T, Yokota RT, Zarogoulidis P, PRIDE Consortium Investigators, Nguyen-Van-Tam JS. Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data. Lancet Respir Med. 2014 May;2(5):395-404. PubMed PMID: 24815805
• Eladawy M, Dominguez SR, Anderson MS, Glodé MP. Kawasaki disease and the pediatric gastroenterologist: a diagnostic challenge. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):297-9. PubMed PMID: 23085893
• Dominguez SR, Anderson MS. Advances in the treatment of Kawasaki disease. Curr Opin Pediatr. 2013 Feb;25(1):103-9. PubMed PMID: 23283289
• Dominguez SR, Dolan SA, West K, Dantes RB, Epson E, Friedman D, Littlehorn CA, Arms LE, Walton K, Servetar E, Frank DN, Kotter CV, Dowell E, Gould CV, Hilden JM, Todd JK. High colonization rate and prolonged shedding of Clostridium difficile in pediatric oncology patients. Clin Infect Dis. 2014 Aug;59(3):401-3. PubMed PMID: 24785235
• Holmes KV, Dominguez SR. The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia. MBio. 2013 Jan 8;4(1):e00548-12. PubMed PMID: 23300251
• Gu SH, Lim BK, Kadjo B, Arai S, Kim JA, Nicolas V, Lalis A, Denys C, Cook JA, Dominguez SR, Holmes KV, Urushadze L, Sidamonidze K, Putkaradze D, Kuzmin IV, Kosoy MY, Song JW, Yanagihara R. Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam. Viruses. 2014 Apr 29;6(5):1897-910. PubMed PMID: 24784569
• Dominguez SR, Shrivastava S, Berglund A, Qian Z, Góes LG, Halpin RA, Fedorova N, Ransier A, Weston PA, Durigon EL, Jerez JA, Robinson CC, Town CD, Holmes KV. Isolation, propagation, genome analysis and epidemiology of HKU1 betacoronaviruses. J Gen Virol. 2014 Apr;95(Pt 4):836-48. PubMed PMID: 24394697
• Frost HM, Robinson CC, Dominguez SR. Epidemiology and clinical presentation of parainfluenza type 4 in children: a 3-year comparative study to parainfluenza types 1-3. J Infect Dis. 2014 Mar 1;209(5):695-702. PubMed PMID: 24133181
• Greninger AL, Messacar K, Dunnebacke T, Naccache SN, Federman S, Bouquet J, Mirsky D, Nomura Y, Yagi S, Glaser C, Vollmer M, Press CA, Klenschmidt-DeMasters BK, Dominguez SR, Chiu CY. Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing. Genome Med. 2015 Dec 1;7(1):113. PubMed PMID: 26620704
• Muthuri SG, Venkatesan S, Myles PR, Leonardi-Bee J, Lim WS, Mamun AA, Anovadiya AP, Araújo WN, Azziz-Baumgartner E, Báez C, Bantar C, Barhoush MM, Bassetti M, Beovic B, Bingisser R, Bonmarin I, Borja-Aburto VH, Cao B, Carratala J, Cuezzo MR, Denholm JT, Dominguez SR, Duarte PA, Dubnov-Raz G, Echavarria M, Fanella S, Fraser J, Gao Z, Gérardin P, Giannella M, Gubbels S, Herberg J, Iglesias AL, Hoeger PH, Hoffmann M, Hu X, Islam QT, Jiménez MF, Kandeel A, Keijzers G, Khalili H, Khandaker G, Knight M, Kusznierz G, Kuzman I, Kwan AM, Amine IL, Langenegger E, Lankarani KB, Leo YS, Linko R, Liu P, Madanat F, Manabe T, Mayo-Montero E, McGeer A, Memish ZA, Metan G, Mikic D, Mohn KG, Moradi A, Nymadawa P, Ozbay B, Ozkan M, Parekh D, Paul M, Poeppl W, Polack FP, Rath BA, Rodríguez AH, Siqueira MM, Skret-Magierlo J, Talarek E, Tang JW, Torres A, Törün SH, Tran D, Uyeki TM, van Zwol A, Vaudry W, Velyvyte D, Vidmar T, Zarogoulidis P, Nguyen-Van-Tam JS. Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an IPD meta-analysis. Influenza Other Respir Viruses. 2015 Nov 25. [Epub ahead of print] PubMed PMID: 26602067
• Dantes R, Epson EE, Dominguez SR, Dolan S, Wang F, Hurst A, Parker SK, Johnston H, West K, Anderson L, Rasheed JK, Moulton-Meissner H, Noble-Wang J, Limbago B, Dowell E, Hilden JM, Guh A, Pollack LA, Gould CV. Investigation of a cluster of Clostridium difficile infections in a pediatric oncology setting. Am J Infect Control. 2015 Oct 22. [Epub ahead of print] PubMed PMID: 26601705
• Messacar K, Abzug MJ, Dominguez SR. 2014 outbreak of enterovirus D68 in North America. J Med Virol. 2015 Oct 21. [Epub ahead of print] PubMed PMID: 26489019
• Midgley CM, Watson JT, Nix WA, Curns AT, Rogers SL, Brown BA, Conover C, Dominguez SR, Feikin DR, Gray S, Hassan F, Hoferka S, Jackson MA, Johnson D, Leshem E, Miller L, Nichols JB, Nyquist AC, Obringer E, Patel A, Patel M, Rha B, Schneider E, Schuster JE, Selvarangan R, Seward JF, Turabelidze G, Oberste MS, Pallansch MA, Gerber SI. Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation. Lancet Respir Med. 2015 Nov;3(11):879-87. PubMed PMID: 26482320
• Messacar K, Dunn J, Khan TZ, Etcheverry A, McFarland EJ, Dominguez SR. Diffuse Nodular Lung Infiltrates in a Well Appearing Three-Year-Old Boy With Recurrent Sinopulmonary Infections and Parotitis. J Pediatric Infect Dis Soc. 2015 Mar;4(1):74-7. PubMed PMID: 26407362
• Dominguez SR, Anderson LJ, Kotter CV, Littlehorn CA, Arms LE, Dowell E, Todd JK, Frank DN. Comparison of Whole-Genome Sequencing and Molecular-Epidemiological Techniques for Clostridium difficile Strain Typing. J Pediatric Infect Dis Soc. 2015 Apr 23. [Epub ahead of print] PubMed PMID: 26407257
• Dominguez SR, Martin B, Heizer H, Jone PN, Tong S, Davidson J, Anderson MS, Glodé MP. Procalcitonin (PCT) and Kawasaki Disease: Does PCT Correlate with IVIG-Resistant Disease, Admission to the Intensive Care Unit, or Development of Coronary Artery Lesions?. J Pediatric Infect Dis Soc. 2015 Apr 20. [Epub ahead of print] PubMed PMID: 26407256
• Rao S, Torok MR, Bagdure D, Cunningham MA, Williams JT, Curtis DJ, Wilson K, Dominguez SR. A comparison of H1N1 influenza among pediatric inpatients in the pandemic and post pandemic era. J Clin Virol. 2015 Oct;71:44-50. PubMed PMID: 26370314
• Turnier JL, Anderson MS, Heizer HR, Jone PN, Glodé MP, Dominguez SR. Concurrent Respiratory Viruses and Kawasaki Disease. Pediatrics. 2015 Sep;136(3):e609-14. PubMed PMID: 26304824
• Olson D, Watkins LK, Demirjian A, Lin X, Robinson CC, Pretty K, Benitez AJ, Winchell JM, Diaz MH, Miller LA, Foo TA, Mason MD, Lauper UL, Kupfer O, Kennedy J, Glodé MP, Kutty PK, Dominguez SR. Outbreak of Mycoplasma pneumoniae-Associated Stevens-Johnson Syndrome. Pediatrics. 2015 Aug;136(2):e386-94. PubMed PMID: 26216320
• Qian Z, Ou X, Góes LG, Osborne C, Castano A, Holmes KV, Dominguez SR. Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1. J Virol. 2015 Sep;89(17):8816-27. PubMed PMID: 26085157
• Phadke D, Patel SS, Dominguez SR, Heizer H, Anderson MS, Glode MP, Jone PN. Tissue Doppler Imaging as a Predictor of Immunoglobulin Resistance in Kawasaki Disease. Pediatr Cardiol. 2015 Dec;36(8):1618-23. PubMed PMID: 25991572
• Greninger AL, Naccache SN, Messacar K, Clayton A, Yu G, Somasekar S, Federman S, Stryke D, Anderson C, Yagi S, Messenger S, Wadford D, Xia D, Watt JP, Van Haren K, Dominguez SR, Glaser C, Aldrovandi G, Chiu CY. A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study. Lancet Infect Dis. 2015 Jun;15(6):671-82. PubMed PMID: 25837569
• Osborne CM, Montano AC, Robinson CC, Schultz-Cherry S, Dominguez SR. Viral gastroenteritis in children in Colorado 2006-2009. J Med Virol. 2015 Jun;87(6):931-9. PubMed PMID: 25776578
• Messacar K, Breazeale G, Wei Q, Robinson CC, Dominguez SR. Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus. J Med Virol. 2015 May;87(5):829-35. PubMed PMID: 25650069
• Messacar K, Schreiner TL, Maloney JA, Wallace A, Ludke J, Oberste MS, Nix WA, Robinson CC, Glodé MP, Abzug MJ, Dominguez SR. A cluster of acute flaccid paralysis and cranial nerve dysfunction temporally associated with an outbreak of enterovirus D68 in children in Colorado, USA. Lancet. 2015 Apr 25;385(9978):1662-71. PubMed PMID: 25638662
• Maloney JA, Mirsky DM, Messacar K, Dominguez SR, Schreiner T, Stence NV. MRI findings in children with acute flaccid paralysis and cranial nerve dysfunction occurring during the 2014 enterovirus D68 outbreak. AJNR Am J Neuroradiol. 2015 Feb;36(2):245-50. PubMed PMID: 25414005
• Rogers AE, Eisenman KM, Dolan SA, Belderson KM, Zauche JR, Tong S, Gralla J, Hilden JM, Wang M, Maloney KW, Dominguez SR. Risk factors for bacteremia and central line-associated blood stream infections in children with acute myelogenous leukemia: A single-institution report. Pediatr Blood Cancer. 2016 Sep 12. [Epub ahead of print] PubMed PMID: 27616655
• Messacar K, Hurst AL, Child J, Campbell K, Palmer C, Hamilton S, Dowell E, Robinson CC, Parker SK, Dominguez SR. Clinical Impact and Provider Acceptability of Real-Time Antimicrobial Stewardship Decision Support for Rapid Diagnostics in Children With Positive Blood Culture Results. J Pediatric Infect Dis Soc. 2016 Aug 19. [Epub ahead of print] PubMed PMID: 27543412
• Phan TG, Messacar K, Dominguez SR, da Costa AC, Deng X, Delwart E. A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis. Arch Virol. 2016 Nov;161(11):3231-5. PubMed PMID: 27522586
• Rao S, Messacar K, Torok MR, Rick AM, Holzberg J, Montano A, Bagdure D, Curtis DJ, Oberste MS, Nix WA, de Masellis G, Robinson CC, Dominguez SR. Enterovirus D68 in Critically Ill Children: A Comparison With Pandemic H1N1 Influenza. Pediatr Crit Care Med. 2016 Nov;17(11):1023-1031. PubMed PMID: 27505715
• Zeft AS, Burns JC, Yeung RS, McCrindle BW, Newburger JW, Dominguez SR, Anderson MS, Arrington C, Shulman ST, Yoon J, Tewelde H, Mix C, Pope CA. Kawasaki Disease and Exposure to Fine Particulate Air Pollution. J Pediatr. 2016 Oct;177:179-183.e1. PubMed PMID: 27496266
• Aliabadi N, Messacar K, Pastula DM, Robinson CC, Leshem E, Sejvar JJ, Nix WA, Oberste MS, Feikin DR, Dominguez SR. Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014. Emerg Infect Dis. 2016 Aug;22(8):1387-94. PubMed PMID: 27434186
• Messacar K, Schreiner TL, Van Haren K, Yang M, Glaser CA, Tyler KL, Dominguez SR. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Ann Neurol. 2016 Sep;80(3):326-38. PubMed PMID: 27422805
• Nelson CA, Farina MA, Olson D, Dominguez SR, McFarland EJ. Visual Diagnosis: 19-year-old Boy with Syncope and Bradycardia. Pediatr Rev. 2016 Jul;37(7):e25-8. PubMed PMID: 27368365
• Messacar K, Breazeale G, Robinson CC, Dominguez SR. Potential clinical impact of the film array meningitis encephalitis panel in children with suspected central nervous system infections. Diagn Microbiol Infect Dis. 2016 Sep;86(1):118-20. PubMed PMID: 27342782
• Messacar K, Abzug MJ, Dominguez SR. The Emergence of Enterovirus-D68. Microbiol Spectr. 2016 Jun;4(3). PubMed PMID: 27337448
• Frank B, Davidson J, Tong S, Martin B, Heizer H, Anderson MS, Glode MP, Dominguez SR, Jone PN. Myocardial Strain and Strain Rate in Kawasaki Disease: Range, Recovery, and Relationship to Systemic Inflammation/Coronary Artery Dilation. J Clin Exp Cardiolog. 2016 Apr;7(4). PubMed PMID: 27182455
• Ou X, Zheng W, Shan Y, Mu Z, Dominguez SR, Holmes KV, Qian Z. Identification of the Fusion Peptide-Containing Region in Betacoronavirus Spike Glycoproteins. J Virol. 2016 Jun 15;90(12):5586-600. PubMed PMID: 27030273
• Messacar K, Hawkins SM, Baker J, Pearce K, Tong S, Dominguez SR, Parker S. Resource Burden During the 2014 Enterovirus D68 Respiratory Disease Outbreak at Children's Hospital Colorado: An Unexpected Strain. JAMA Pediatr. 2016 Mar;170(3):294-7. PubMed PMID: 26783716
• Dominguez SR, Messacar KB, and Levin MJ. Infections: Parasitic & Mycotic. In Current Pediatric Diagnosis and Treatment, 22th Edition. Eds. Hay WW, Levin MJ, Abzug, M and RR Deterding. McGraw-Hill, 2016.
• Messacar K, Abzug MJ, and Dominguez SR. “The Emergence of Enterovirus D68.” In Emerging Infections, 10th Edition. Eds. Scheld WM, Hughes JM, and RJ Whitley. ASM Press, 2016
• Dominguez SR, Hamilton S, and Robinson CC. “Microbrief: Gastrointestinal Panel” Contagious Comments Vol 31 (2), 2016.
• Dominguez SR, Hamilton S, and Robinson CC. Microbrief: Clostridium difficile.” Contagious Comments Vol 31 (4), 2016
• Dominguez SR. “Zika Virus: Parents’ Top 10 Questions.” http://www.childrenscolorado.org/about/news/2016/zika-virus-parents-questions
• Brumbaugh DE, De Zoeten EF, Pyo-Twist A, Fidanza S, Hughes S, Dolan SA, Child J, Dominguez SR. An Intragastric Fecal Microbiota Transplantation Program for Treatment of Recurrent Clostridium difficile in Children is Efficacious, Safe, and Inexpensive. J Pediatr. 2017 Nov 30. [Epub ahead of print] PubMed PMID: 29198534
• Messacar K, Parker SK, Todd JK, Dominguez SR. Reply to "Integrated Stewardship Model Comprising Antimicrobial, Infection Prevention, and Diagnostic Stewardship (AID Stewardship)". J Clin Microbiol. 2017 Nov;55(11):3308. PubMed PMID: 29066568
• Messacar K, Abzug MJ, Dominguez SR. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance. J Med Virol. 2018 Jan;90(1):1-2. PubMed PMID: 29023852
• Martin JA, Messacar K, Yang ML, Maloney JA, Lindwall J, Carry T, Kenyon P, Sillau SH, Oleszek J, Tyler KL, Dominguez SR, Schreiner TL. Outcomes of Colorado children with acute flaccid myelitis at 1 year. Neurology. 2017 Jul 11;89(2):129-137. PubMed PMID: 28615421
• Ou X, Guan H, Qin B, Mu Z, Wojdyla JA, Wang M, Dominguez SR, Qian Z, Cui S. Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1. Nat Commun. 2017 May 23;8:15216. PubMed PMID: 28534504
• Messacar K, Robinson CC, Pretty K, Yuan J, Dominguez SR. Surveillance for enterovirus D68 in colorado children reveals continued circulation. J Clin Virol. 2017 Jul;92:39-41. PubMed PMID: 28521212
• Olson D, Abbott J, Lin C, Prok L, Dominguez SR. Characterization of Children With Recurrent Episodes of Stevens Johnson Syndrome. J Pediatric Infect Dis Soc. 2017 Sep 1;6(3):e140-e143. PubMed PMID: 28339562
• Watkins LKF, Olson D, Diaz MH, Lin X, Demirjian A, Benitez AJ, Winchell JM, Robinson CC, Bol KA, Glodé MP, Dominguez SR, Miller LA, Kutty PK. Epidemiology and Molecular Characteristics of Mycoplasma pneumoniae During an Outbreak of M. pneumoniae-associated Stevens-Johnson Syndrome. Pediatr Infect Dis J. 2017 Jun;36(6):564-571. PubMed PMID: 28060039
• Messacar K, Parker SK, Todd JK, Dominguez SR. Implementation of Rapid Molecular Infectious Disease Diagnostics: the Role of Diagnostic and Antimicrobial Stewardship. J Clin Microbiol. 2017 Mar;55(3):715-723. PubMed PMID: 28031432
• Rogers AE, Eisenman KM, Dolan SA, Belderson KM, Zauche JR, Tong S, Gralla J, Hilden JM, Wang M, Maloney KW, Dominguez SR. Risk factors for bacteremia and central line-associated blood stream infections in children with acute myelogenous leukemia: A single-institution report. Pediatr Blood Cancer. 2017 Mar;64(3). PubMed PMID: 27616655
• Messacar K, Hurst AL, Child J, Campbell K, Palmer C, Hamilton S, Dowell E, Robinson CC, Parker SK, Dominguez SR. Clinical Impact and Provider Acceptability of Real-Time Antimicrobial Stewardship Decision Support for Rapid Diagnostics in Children With Positive Blood Culture Results. J Pediatric Infect Dis Soc. 2017 Sep 1;6(3):267-274. PubMed PMID: 27543412
• Messacar K, Robinson CC, Dominguez SR. Letter to the editor: economic analysis lacks external validity to support universal syndromic testing for suspected meningitis/encephalitis. Future Microbiol. 2018 Nov;13:1553-1554. PubMed PMID: 30421966
• Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2018 Nov 9. [Epub ahead of print] PubMed PMID: 30413631
• Schubert RD, Hawes IA, Ramachandran PS, Ramesh A, Crawford ED, Pak JE, Wu W, Cheung CK, O'Donovan BD, Tato CM, Lyden A, Tan M, Sit R, Sowa GA, Sample HA, Zorn KC, Banerji D, Khan LM, Bove R, Hauser SL, Gelfand AA, Johnson-Kerner BL, Nash K, Krishnamoorthy KS, Chitnis T, Ding JZ, McMillan HJ, Chiu CY, Briggs B, Glaser CA, Yen C, Chu V, Wadford DA, Dominguez SR, Ng TFF, Marine RL, Lopez AS, Nix WA, Soldatos A, Gorman MP, Benson L, Messacar K, Konopka-Anstadt JL, Oberste MS, DeRisi JL, Wilson MR. Pan-viral serology implicates enteroviruses in acute flaccid myelitis. Nat Med. 2019 Nov;25(11):1748-1752. PubMed PMID: 31636453
• Messacar K, Abzug MJ, Dominguez SR. Acute Flaccid Myelitis Surveillance: A Signal Through the Noise. Pediatrics. 2019 Nov;144(5). PubMed PMID: 31591134
• Tremoulet AH, Jain S, Jone PN, Best BM, Duxbury EH, Franco A, Printz B, Dominguez SR, Heizer H, Anderson MS, Glodé MP, He F, Padilla RL, Shimizu C, Bainto E, Pancheri J, Cohen HJ, Whitin JC, Burns JC. Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm. J Pediatr. 2019 Dec;215:107-117.e12. PubMed PMID: 31561960
• Messacar K, Dominguez SR. Blood PCR testing for enteroviruses in young children. Lancet Infect Dis. 2018 Oct 30. [Epub ahead of print] PubMed PMID: 30389483
• Gaensbauer JT, Lamb M, Calvimontes DM, Asturias EJ, Kamidani S, Contreras-Roldan IL, Dominguez SR, Robinson CC, Zacarias A, Berman S, Melgar MA. Identification of Enteropathogens by Multiplex PCR among Rural and Urban Guatemalan Children with Acute Diarrhea. Am J Trop Med Hyg. 2019 Sep;101(3):534-540. PubMed PMID: 31392942
• Searns J, Cataldi JR, McCormack K, Simões E, Messacar K, Dominguez SR. A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection. J Pediatric Infect Dis Soc. 2018 Oct 9. [Epub ahead of print] PubMed PMID: 30299497
• Dominguez SR, Birkholz M, Anderson MS, Heizer H, Jone PN, Glode MP, Todd JK. Diagnostic and Treatment Trends in Children With Kawasaki Disease in the United States, 2006-2015. Pediatr Infect Dis J. 2019 Oct;38(10):1010-1014. PubMed PMID: 31365480
• West K, Janelle S, Schutz K, Hamilton S, Mayo K, Cichon MK, Nyquist AC, Bamberg WM, Dominguez SR. Outbreak of Serratia marcescens bacteremia in pediatric patients epidemiologically linked to pre-filled heparin flushes. Infect Control Hosp Epidemiol. 2019 Oct;40(10):1201-1202. PubMed PMID: 31340879
• Messacar K, Hamilton SL, Prinzi AM, Mitchell JC, Beil ED, Dowell EB, Dominguez SR. Rapid identification of nonblood sterile site broth cultures using the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2018 Jul 31. [Epub ahead of print] PubMed PMID: 30213466
• Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azziz-Baumgartner E, Bajjou T, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borja-Aburto VH, Burgmann H, Cao B, Carratala J, Chinbayar T, Cilloniz C, Denholm JT, Dominguez SR, Duarte PAD, Dubnov-Raz G, Fanella S, Gao Z, Gérardin P, Giannella M, Gubbels S, Herberg J, Higuera Iglesias AL, Hoeger PH, Hu XY, Islam QT, Jiménez MF, Keijzers G, Khalili H, Kusznierz G, Kuzman I, Langenegger E, Lankarani KB, Leo YS, Libster RP, Linko R, Madanat F, Maltezos E, Mamun A, Manabe T, Metan G, Mickiene A, Mikic D, Mohn KGI, Oliva ME, Ozkan M, Parekh D, Paul M, Rath BA, Refaey S, Rodríguez AH, Sertogullarindan B, Skret-Magierlo J, Somer A, Talarek E, Tang JW, To K, Tran D, Uyeki TM, Vaudry W, Vidmar T, Zarogoulidis P, Nguyen-Van-Tam JS. Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection. J Infect Dis. 2019 Jul 17. [Epub ahead of print] PubMed PMID: 31314899
• Kirkley MJ, Robinson C, Dominguez SR, Messacar K. Neonatal parechovirus infection mimicking a surgical abdomen. BMJ Case Rep. 2019 Jun 26;12(6). PubMed PMID: 31248894
• Olson CA, Dominguez SR, Miller S, Chiu CY, Messacar K. Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing. J Pediatr. 2019 Sep;212:228-231. PubMed PMID: 31208781
• Searns JB, Gralla J, Parker SK, Dominguez SR. Potential Clinical Effects of a Novel Rapid Diagnostic Panel for Pediatric Musculoskeletal Infections. J Pediatric Infect Dis Soc. 2019 Jun 13. [Epub ahead of print] PubMed PMID: 31194251
• Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY. Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis. N Engl J Med. 2019 Jun 13;380(24):2327-2340. PubMed PMID: 31189036
• Messacar K, Pretty K, Reno S, Dominguez SR. Continued biennial circulation of enterovirus D68 in Colorado. J Clin Virol. 2019 Apr;113:24-26. PubMed PMID: 30825833
• Rao S, Martin J, Ahearn MA, Osborne C, Moss A, Dempsey A, Dominguez SR, Weinberg A, Messacar KB. Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016-2017 Season. J Pediatric Infect Dis Soc. 2018 Dec 27. [Epub ahead of print] PubMed PMID: 30590598
• Messacar K, Burakoff A, Nix WA, Rogers S, Oberste MS, Gerber SI, Spence-Davizon E, Herlihy R, Dominguez SR. Notes from the Field: Enterovirus A71 Neurologic Disease in Children - Colorado, 2018. MMWR Morb Mortal Wkly Rep. 2018 Sep 14;67(36):1017-1018. PubMed PMID: 30212441
• Searns JB, Robinson CC, Wei Q, Yuan J, Hamilton S, Pretty K, Donaldson N, Parker SK, Dominguez SR. Validation of a novel molecular diagnostic panel for pediatric musculoskeletal infections: Integration of the Cepheid Xpert MRSA/SA SSTI and laboratory-developed real-time PCR assays for clindamycin resistance genes and Kingella kingae detection. J Microbiol Methods. 2019 Jan;156:60-67. PubMed PMID: 30527965
• Messacar K, Robinson CC, Dominguez SR. Letter to the editor: economic analysis lacks external validity to support universal syndromic testing for suspected meningitis/encephalitis. Future Microbiol. 2018 Nov;13:1553-1554. PubMed PMID: 30421966
• Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2019 Apr 30;92(18):e2118-e2126. PubMed PMID: 30413631
• Dominguez SR, Pretty K, Hengartner R, Robinson CC. Comparison of Herpes Simplex Virus PCR with Culture for Virus Detection in Multisource Surface Swab Specimens from Neonates. J Clin Microbiol. 2018 Oct;56(10). PubMed PMID: 29875197
• Messacar K, Dominguez SR. Blood PCR testing for enteroviruses in young children. Lancet Infect Dis. 2018 Dec;18(12):1299-1301. PubMed PMID: 30389483
• Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, Abzug MJ, Dominguez SR. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018 Aug;18(8):e239-e247. PubMed PMID: 29482893
• Searns J, Cataldi JR, McCormack K, Simões E, Messacar K, Dominguez SR. A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection. J Pediatric Infect Dis Soc. 2019 Jul 1;8(3):282-283. PubMed PMID: 30299497
• Messacar K, Dominguez SR. Blood PCR testing for enteroviruses in young children. Lancet Infect Dis. 2018 Dec;18(12):1299-1301. PubMed PMID: 30389483
• Jone PN, Anderson MS, Mulvahill MJ, Heizer H, Glodé MP, Dominguez SR. Infliximab Plus Intravenous Immunoglobulin (IVIG) Versus IVIG Alone as Initial Therapy in Children With Kawasaki Disease Presenting With Coronary Artery Lesions: Is Dual Therapy More Effective?. Pediatr Infect Dis J. 2018 Oct;37(10):976-980. PubMed PMID: 29461447
• Saporta-Keating SR, Simões EAF, Yu G, Federman S, Mirsky D, Dominguez SR, Chiu CY, Messacar K. A Child With Intermittent Headaches and Eosinophilic Meningitis. J Pediatric Infect Dis Soc. 2018 Feb 9. [Epub ahead of print] PubMed PMID: 29438532
• Messacar K, Hamilton SL, Prinzi AM, Mitchell JC, Beil ED, Dowell EB, Dominguez SR. Rapid identification of nonblood sterile site broth cultures using the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2019 Jan;93(1):22-23. PubMed PMID: 30213466
• Messacar K, Burakoff A, Nix WA, Rogers S, Oberste MS, Gerber SI, Spence-Davizon E, Herlihy R, Dominguez SR. Notes from the Field: Enterovirus A71 Neurologic Disease in Children - Colorado, 2018. MMWR Morb Mortal Wkly Rep. 2018 Sep 14;67(36):1017-1018. PubMed PMID: 30212441
• Dominguez SR, Pretty K, Hengartner R, Robinson CC. Comparison of Herpes Simplex Virus PCR with Culture for Virus Detection in Multisource Surface Swab Specimens from Neonates. J Clin Microbiol. 2018 Oct;56(10). PubMed PMID: 29875197
• Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, Abzug MJ, Dominguez SR. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018 Aug;18(8):e239-e247. PubMed PMID: 29482893
• Jone PN, Anderson MS, Mulvahill MJ, Heizer H, Glodé MP, Dominguez SR. Infliximab Plus Intravenous Immunoglobulin (IVIG) Versus IVIG Alone as Initial Therapy in Children With Kawasaki Disease Presenting With Coronary Artery Lesions: Is Dual Therapy More Effective?. Pediatr Infect Dis J. 2018 Oct;37(10):976-980. PubMed PMID: 29461447
• Messacar K, Abzug MJ, Dominguez SR. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance. J Med Virol. 2018 Jan;90(1):1-2. PubMed PMID: 29023852
• Brumbaugh DE, De Zoeten EF, Pyo-Twist A, Fidanza S, Hughes S, Dolan SA, Child J, Dominguez SR. An Intragastric Fecal Microbiota Transplantation Program for Treatment of Recurrent Clostridium difficile in Children is Efficacious, Safe, and Inexpensive. J Pediatr. 2018 Mar;194:123-127.e1. PubMed PMID: 29198534
• Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2018 Mar;32(1):145-162. PubMed PMID: 29224854
• Nycz BT, Dominguez SR, Friedman D, Hilden JM, Ir D, Robertson CE, Frank DN. Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients. PLoS One. 2018;13(1):e0191232. PubMed PMID: 29329346
• Nycz BT, Dominguez SR, Friedman D, Hilden JM, Ir D, Robertson CE, Frank DN. Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients. PLoS One. 2018;13(1):e0191232. PubMed PMID: 29329346
• Saporta-Keating SR, Simões EAF, Yu G, Federman S, Mirsky D, Dominguez SR, Chiu CY, Messacar K. A Child With Intermittent Headaches and Eosinophilic Meningitis. J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):355-357. PubMed PMID: 29438532
• Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2018 Mar;32(1):145-162. PubMed PMID: 29224854
• Brumbaugh DE, De Zoeten EF, Pyo-Twist A, Fidanza S, Hughes S, Dolan SA, Child J, Dominguez SR. An Intragastric Fecal Microbiota Transplantation Program for Treatment of Recurrent Clostridium difficile in Children is Efficacious, Safe, and Inexpensive. J Pediatr. 2018 Mar;194:123-127.e1. PubMed PMID: 29198534
• Messacar K, Abzug MJ, Dominguez SR. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance. J Med Virol. 2018 Jan;90(1):1-2. PubMed PMID: 29023852
• Nycz BT, Pretty K, Gomez-Trujillo A, Sanchez B, Dominguez SR. Description of Enteropathic Escherichia coli Species in Pediatric Patients at a Quaternary Children's Hospital. J Pediatric Infect Dis Soc. 2019 Dec 5. [Epub ahead of print] PubMed PMID: 31803928
• Searns JB, Robinson CC, Wei Q, Yuan J, Hamilton S, Pretty K, Donaldson N, Parker SK, Dominguez SR. Validation of a novel molecular diagnostic panel for pediatric musculoskeletal infections: Integration of the cepheid Xpert MRSA/SA SSTI and laboratory-developed real-time PCR assays for clindamycin resistance genes and Kingella kingae detection. J Microbiol Methods. 2018 Dec 7. [Epub ahead of print] PubMed PMID: 30527965
• Nycz BT, Dominguez SR, Friedman D, Hilden JM, Ir D, Robertson CE, Frank DN. Correction: Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients. PLoS One. 2018;13(5):e0197530. PubMed PMID: 29746574
• Shane AL, Sato AI, Kao C, Adler-Shohet FC, Vora SB, Auletta JJ, Nachman S, Raabe VN, Inagaki K, Akinboyo IC, Woods C, Alsulami AO, Kainth MK, Santos RP, Espinosa CM, Burns JE, Cunningham CK, Dominguez SR, Martinez BL, Zhu F, Crews J, Kitano T, Saiman L, Kotloff K. A Pediatric Infectious Diseases Perspective of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Novel Coronavirus Disease 2019 (COVID-19) in Children. J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):596-608. PubMed PMID: 32840614
• DomBourian MG, Annen K, Huey L, Andersen G, Merkel PA, Jung S, Dominguez SR, Knight V. Analysis of COVID-19 convalescent plasma for SARS-CoV-2 IgG using two commercial immunoassays. J Immunol Methods. 2020 Nov;486:112837. PubMed PMID: 32828791
• Gould CV, Messacar K, Dominguez SR, Panella A, Tobolowsky F, Fischer M. Evaluation for Arboviral Infection Among Children Hospitalized in Colorado With Aseptic Meningitis and Encephalitis. Pediatr Infect Dis J. 2020 Nov;39(11):e382-e384. PubMed PMID: 32773665
• Jone PN, Korst A, Karimpour-Fard A, Thomas T, Dominguez SR, Heizer H, Anderson MS, Glode MP, Sucharov CC, Miyamoto SD. Circulating microRNAs differentiate Kawasaki Disease from infectious febrile illnesses in childhood. J Mol Cell Cardiol. 2020 Sep;146:12-18. PubMed PMID: 32634388
• Messacar K, Gaensbauer JT, Birkholz M, Palmer C, Todd JK, Tyler KL, Dominguez SR. Impact of FilmArray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period. Diagn Microbiol Infect Dis. 2020 Aug;97(4):115085. PubMed PMID: 32559588
• Dodson DS, Dominguez SR, MacBrayne CE, Williams MC, Parker SK. Vancomycin-Nonsusceptible Enterococci Mediated by vanC at a Large Children's Hospital: Prevalence, Susceptibility, and Impact on Care of Enterococcal Bacteremia. Open Forum Infect Dis. 2020 May;7(5):ofaa160. PubMed PMID: 32478121
• Hao S, Ling XB, Kanegaye JT, Bainto E, Dominguez SR, Heizer H, Jone PN, Anderson MS, Jaggi P, Baker A, Son MB, Newburger JW, Ashouri N, McElhinney DB, Burns JC, Whitin JC, Cohen HJ, Tremoulet AH. Multicentre validation of a computer-based tool for differentiation of acute Kawasaki disease from clinically similar febrile illnesses. Arch Dis Child. 2020 Aug;105(8):772-777. PubMed PMID: 32139365
• Cotter JM, Thomas J, Birkholz M, Brittan M, Ambroggio L, Dolan S, Pearce K, Todd J, Dominguez SR. Impact of Multiplex Testing on the Identification of Pediatric Clostridiodes Difficile. J Pediatr. 2020 Mar;218:157-165.e3. PubMed PMID: 32089179
• Mayer EF, Maron G, Dallas RH, Ferrolino J, Tang L, Sun Y, Danziger-Isakov L, Paulsen GC, Fisher BT, Vora SB, Englund J, Steinbach WJ, Michaels M, Green M, Yeganeh N, Gibson JE, Dominguez SR, Nicholson MR, Dulek DE, Ardura MI, Rajan S, Gonzalez BE, Beneri C, Herold BC. A multicenter study to define the epidemiology and outcomes of Clostridioides difficile infection in pediatric hematopoietic cell and solid organ transplant recipients. Am J Transplant. 2020 Aug;20(8):2133-2142. PubMed PMID: 32064754
• Tran P, Dowell E, Hamilton S, Dolan SA, Messacar K, Dominguez SR, Todd J. Two Blood Cultures With Age-Appropriate Volume Enhance Suspected Sepsis Decision-Making. Open Forum Infect Dis. 2020 Feb;7(2):ofaa028. PubMed PMID: 32055641
• Meyers L, Dien Bard J, Galvin B, Nawrocki J, Niesters HGM, Stellrecht KA, St George K, Daly JA, Blaschke AJ, Robinson C, Wang H, Cook CV, Hassan F, Dominguez SR, Pretty K, Naccache S, Olin KE, Althouse BM, Jones JD, Ginocchio CC, Poritz MA, Leber A, Selvarangan R. Enterovirus D68 outbreak detection through a syndromic disease epidemiology network. J Clin Virol. 2020 Mar;124:104262. PubMed PMID: 32007841
• Messacar K, Spence-Davizon E, Osborne C, Press C, Schreiner TL, Martin J, Messer R, Maloney J, Burakoff A, Barnes M, Rogers S, Lopez AS, Routh J, Gerber SI, Oberste MS, Nix WA, Abzug MJ, Tyler KL, Herlihy R, Dominguez SR. Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study. Lancet Infect Dis. 2020 Feb;20(2):230-239. PubMed PMID: 31859216
• Nycz BT, Pretty K, Gomez-Trujillo A, Sanchez B, Dominguez SR. Description of Enteropathic Escherichia coli Species in Pediatric Patients at a Quaternary Children's Hospital. J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):573-579. PubMed PMID: 31803928
• Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azziz-Baumgartner E, Bajjou T, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borja-Aburto VH, Burgmann H, Cao B, Carratala J, Chinbayar T, Cilloniz C, Denholm JT, Dominguez SR, Duarte PAD, Dubnov-Raz G, Fanella S, Gao Z, Gérardin P, Giannella M, Gubbels S, Herberg J, Higuera Iglesias AL, Hoeger PH, Hu XY, Islam QT, Jiménez MF, Keijzers G, Khalili H, Kusznierz G, Kuzman I, Langenegger E, Lankarani KB, Leo YS, Libster RP, Linko R, Madanat F, Maltezos E, Mamun A, Manabe T, Metan G, Mickiene A, Mikic D, Mohn KGI, Oliva ME, Ozkan M, Parekh D, Paul M, Rath BA, Refaey S, Rodríguez AH, Sertogullarindan B, Skret-Magierlo J, Somer A, Talarek E, Tang JW, To K, Tran D, Uyeki TM, Vaudry W, Vidmar T, Zarogoulidis P, Nguyen-Van-Tam JS. Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection. J Infect Dis. 2020 Jan 14;221(3):356-366. PubMed PMID: 31314899
• Searns JB, Gralla J, Parker SK, Dominguez SR. Potential Clinical Effects of a Novel Rapid Diagnostic Panel for Pediatric Musculoskeletal Infections. J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):382-385. PubMed PMID: 31194251
• Rao S, Martin J, Ahearn MA, Osborne C, Moss A, Dempsey A, Dominguez SR, Weinberg A, Messacar KB. Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016-2017 Season. J Pediatric Infect Dis Soc. 2020 Feb 28;9(1):71-74. PubMed PMID: 30590598
• Graff K, Dominguez SR, Messacar K. Metagenomic Next-Generation Sequencing for Diagnosis of Pediatric Meningitis and Encephalitis: A Review. J Pediatric Infect Dis Soc. 2021 Dec 24;10(Supplement_4):S78-S87. PubMed PMID: 34951470
• Cole LD, Osborne CM, Silveira LJ, Rao S, Lockwood JM, Kunkel MJ, MacBrayne CE, Heizer HR, Anderson MS, Jone PN, Dominguez SR. IVIG Compared to IVIG Plus Infliximab in Multisystem Inflammatory Syndrome in Children. Pediatrics. 2021 Sep 22. [Epub ahead of print] PubMed PMID: 34814192
• Burney JA, DeHaan LL, Shimizu C, Bainto EV, Newburger JW, DeBiasi RL, Dominguez SR, Portman MA, Melish M, Bratincsak A, Fabi M, Corinaldesi E, Yu JJ, Gee P, Kitano N, Tremoulet AH, Cayan DR, Burns JC. Temporal clustering of Kawasaki disease cases around the world. Sci Rep. 2021 Nov 19;11(1):22584. PubMed PMID: 34799633
• Dolan SA, Mulcahy Levy J, Moss A, Pearce K, Butler M, Jung S, Dominguez SR, Mwangi E, Maloney K, Rao S. SARS-CoV-2 persistence in immunocompromised children. Pediatr Blood Cancer. 2021 Dec;68(12):e29277. PubMed PMID: 34453477
• Graff KE, Windsor WJ, Calvimontes DM, Melgar MA, Galvez N, Rivera JG, Dominguez SR, Asturias EJ, Gordillo MR. Antimicrobial Resistance Trends at a Pediatric Hospital in Guatemala City, 2005-2019. J Pediatric Infect Dis Soc. 2021 Aug 26. [Epub ahead of print] PubMed PMID: 34437683
• Bonavia A, Dominguez SR, Dveksler G, Gagneten S, Howard M, Jeffers S, Qian Z, Smith MK, Thackray LB, Tresnan DB, Wentworth DE, Wessner DR, Williams RK, Miura TA. Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field. Viruses. 2022 Jul 20;14(7). PubMed PMID: 35891553
• Graff KE, Palmer C, Anarestani T, Velasquez D, Hamilton S, Pretty K, Parker S, Dominguez SR. Clinical Impact of the Expanded BioFire Blood Culture Identification 2 Panel in a U.S. Children's Hospital. Microbiol Spectr. 2021 Sep 3;9(1):e0042921. PubMed PMID: 34431685
• Windsor WJ, Lamb MM, Dominguez SR, Mistry RD, Rao S. Clinical characteristics and illness course based on pathogen among children with respiratory illness presenting to an emergency department. J Med Virol. 2022 Dec;94(12):6103-6110. PubMed PMID: 35882541
• Frost HM, Sebastian T, Keith A, Kurtz M, Dominguez SR, Parker SK, Jenkins TC. COVID-19 and Acute Otitis Media in Children: A Case Series. J Prim Care Community Health. 2022 Jan-Dec;13:21501319221082351. PubMed PMID: 35289210
• Messacar K, Palmer C, Gregoire L, Elliott A, Ackley E, Perraillon MC, Tyler KL, Dominguez SR. Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection. J Pediatr. 2022 May;244:161-168.e1. PubMed PMID: 35150729
• Ackley ER, Tchou MJ, Press CA, Parker SK, Dominguez SR, Gaensbauer J, Messacar K. AKI In Suspected Meningitis/Encephalitis May Be "Avoidable Kidney Injury". Hosp Pediatr. 2021 Aug;11(8):e167-e169. PubMed PMID: 34244336
• Nguyen-Tran H, Park SW, Messacar K, Dominguez SR, Vogt MR, Permar S, Permaul P, Hernandez M, Douek DC, McDermott AB, Metcalf CJE, Grenfell B, Spaulding AB. Enterovirus D68: a test case for the use of immunological surveillance to develop tools to mitigate the pandemic potential of emerging pathogens. Lancet Microbe. 2022 Feb;3(2):e83-e85. PubMed PMID: 35036969
• Rao S, Lamb MM, Moss A, Mistry RD, Grice K, Ahmed W, Santos-Cantu D, Kitchen E, Patel C, Ferrari I, Dominguez SR. Effect of Rapid Respiratory Virus Testing on Antibiotic Prescribing Among Children Presenting to the Emergency Department With Acute Respiratory Illness: A Randomized Clinical Trial. JAMA Netw Open. 2021 Jun 1;4(6):e2111836. PubMed PMID: 34086034
• Cotter JM, Thomas J, Birkholz M, Ambroggio L, Holstein J, Dominguez SR. Clinical Impact of a Diagnostic Gastrointestinal Panel in Children. Pediatrics. 2021 May;147(5). PubMed PMID: 33837134
• Graff K, Smith C, Silveira L, Jung S, Curran-Hays S, Jarjour J, Carpenter L, Pickard K, Mattiucci M, Fresia J, McFarland EJ, Dominguez SR, Abuogi L. Risk Factors for Severe COVID-19 in Children. Pediatr Infect Dis J. 2021 Apr 1;40(4):e137-e145. PubMed PMID: 33538539
• Rao S, Martin J, Ahearn MA, Osborne C, Moss A, Dempsey A, Dominguez SR, Weinberg A, Messacar KB. Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016-2017 Season. J Pediatric Infect Dis Soc. 2020 Feb 28;9(1):71-74. PubMed PMID: 30590598
• Park SY, Coufal NG, Dominguez SR, Farnaes L, Messacar K, Goldman FD. Gaps in diagnosing suspected infection in immunocompromised children with cancer: A systematic review. Pediatr Blood Cancer. 2023 Dec 7;:e30794. [Epub ahead of print] PubMed PMID: 38059641
• Butler M, Breazeale G, Mwangi E, Dowell E, Dominguez SR, Lamberth L, Hultén KG, Jung SA. Development and validation of a multiplex real-time PCR assay for detection and quantification of Streptococcus pneumoniae in pediatric respiratory samples. Microbiol Spectr. 2023 Nov 8;:e0211823. [Epub ahead of print] PubMed PMID: 37937989
• Searns JB, Gralla J, Parker SK, Dominguez SR. Potential Clinical Effects of a Novel Rapid Diagnostic Panel for Pediatric Musculoskeletal Infections. J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):382-385. PubMed PMID: 31194251
• Ho EC, Cotter JM, Thomas J, Birkholz M, Dominguez SR. Factors Associated With Actionable Gastrointestinal Panel Results in Hospitalized Children. Hosp Pediatr. 2023 Dec 1;13(12):1115-1123. PubMed PMID: 37936503
• Nguyen-Tran H, Thompson C, Butler M, Miller KR, Pyle L, Jung S, Rogers S, Ng TFF, Routh J, Dominguez SR, Messacar K. Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission among Household Contacts, Colorado, USA. Emerg Infect Dis. 2023 Nov;29(11):2315-2324. PubMed PMID: 37877582
• Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azziz-Baumgartner E, Bajjou T, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borja-Aburto VH, Burgmann H, Cao B, Carratala J, Chinbayar T, Cilloniz C, Denholm JT, Dominguez SR, Duarte PAD, Dubnov-Raz G, Fanella S, Gao Z, Gérardin P, Giannella M, Gubbels S, Herberg J, Higuera Iglesias AL, Hoeger PH, Hu XY, Islam QT, Jiménez MF, Keijzers G, Khalili H, Kusznierz G, Kuzman I, Langenegger E, Lankarani KB, Leo YS, Libster RP, Linko R, Madanat F, Maltezos E, Mamun A, Manabe T, Metan G, Mickiene A, Mikic D, Mohn KGI, Oliva ME, Ozkan M, Parekh D, Paul M, Rath BA, Refaey S, Rodríguez AH, Sertogullarindan B, Skret-Magierlo J, Somer A, Talarek E, Tang JW, To K, Tran D, Uyeki TM, Vaudry W, Vidmar T, Zarogoulidis P, Nguyen-Van-Tam JS. Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection. J Infect Dis. 2020 Jan 14;221(3):356-366. PubMed PMID: 31314899
• Nycz BT, Pretty K, Gomez-Trujillo A, Sanchez B, Dominguez SR. Description of Enteropathic Escherichia coli Species in Pediatric Patients at a Quaternary Children's Hospital. J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):573-579. PubMed PMID: 31803928
• Messacar K, Spence-Davizon E, Osborne C, Press C, Schreiner TL, Martin J, Messer R, Maloney J, Burakoff A, Barnes M, Rogers S, Lopez AS, Routh J, Gerber SI, Oberste MS, Nix WA, Abzug MJ, Tyler KL, Herlihy R, Dominguez SR. Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study. Lancet Infect Dis. 2020 Feb;20(2):230-239. PubMed PMID: 31859216
• Meyers L, Dien Bard J, Galvin B, Nawrocki J, Niesters HGM, Stellrecht KA, St George K, Daly JA, Blaschke AJ, Robinson C, Wang H, Cook CV, Hassan F, Dominguez SR, Pretty K, Naccache S, Olin KE, Althouse BM, Jones JD, Ginocchio CC, Poritz MA, Leber A, Selvarangan R. Enterovirus D68 outbreak detection through a syndromic disease epidemiology network. J Clin Virol. 2020 Mar;124:104262. PubMed PMID: 32007841
• Ho EC, Cataldi JR, Silveira LJ, Birkholz M, Loi MM, Osborne CM, Dominguez SR. Outbreak of Invasive Group A Streptococcus in Children-Colorado, October 2022-April 2023. J Pediatric Infect Dis Soc. 2023 Oct 28;12(10):540-548. PubMed PMID: 37792995
• Frost HM, Jenkins TC, Sebastian T, Parker SK, Keith A, Kurtz M, Fletcher DR, Wilson ML, Dominguez SR. Reliability of nasopharyngeal PCR for the detection of otopathogens in children with uncomplicated acute otitis media compared to culture. Diagn Microbiol Infect Dis. 2023 Oct;107(2):116040. PubMed PMID: 37549633
• Tran P, Dowell E, Hamilton S, Dolan SA, Messacar K, Dominguez SR, Todd J. Two Blood Cultures With Age-Appropriate Volume Enhance Suspected Sepsis Decision-Making. Open Forum Infect Dis. 2020 Feb;7(2):ofaa028. PubMed PMID: 32055641
• Nguyen-Tran H, Reno S, Mwangi E, Mentel M, Hengartner R, Dominguez SR, Messacar K, Jung SA. Qualitative detection of enterovirus D68 from PrimeStore® molecular transport medium: implications for home- and self-collection. Diagn Microbiol Infect Dis. 2023 Aug;106(4):115976. PubMed PMID: 37267740
• Mayer EF, Maron G, Dallas RH, Ferrolino J, Tang L, Sun Y, Danziger-Isakov L, Paulsen GC, Fisher BT, Vora SB, Englund J, Steinbach WJ, Michaels M, Green M, Yeganeh N, Gibson JE, Dominguez SR, Nicholson MR, Dulek DE, Ardura MI, Rajan S, Gonzalez BE, Beneri C, Herold BC. A multicenter study to define the epidemiology and outcomes of Clostridioides difficile infection in pediatric hematopoietic cell and solid organ transplant recipients. Am J Transplant. 2020 Aug;20(8):2133-2142. PubMed PMID: 32064754
• Cotter JM, Thomas J, Birkholz M, Brittan M, Ambroggio L, Dolan S, Pearce K, Todd J, Dominguez SR. Impact of Multiplex Testing on the Identification of Pediatric Clostridiodes Difficile. J Pediatr. 2020 Mar;218:157-165.e3. PubMed PMID: 32089179
• Rao S, Armistead I, Tyler A, Lensing M, Dominguez SR, Alden NB. Respiratory Syncytial Virus, Influenza, and Coronavirus Disease 2019 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season. J Pediatr. 2023 Sep;260:113491. PubMed PMID: 37201680
• Rao S, Armistead I, Messacar K, Alden NB, Schmoll E, Austin E, Dominguez SR. Shifting Epidemiology and Severity of Respiratory Syncytial Virus in Children During the COVID-19 Pandemic. JAMA Pediatr. 2023 Jul 1;177(7):730-732. PubMed PMID: 37184852
• O'Brien SC, Cole LD, Albanese BA, Mahon A, Knight V, Williams N, Severson R, Burakoff A, Alden NB, Dominguez SR. SARS-CoV-2 Seroprevalence Compared with Confirmed COVID-19 Cases among Children, Colorado, USA, May-July 2021. Emerg Infect Dis. 2023 May;29(5):929-936. PubMed PMID: 36972709
• Hao S, Ling XB, Kanegaye JT, Bainto E, Dominguez SR, Heizer H, Jone PN, Anderson MS, Jaggi P, Baker A, Son MB, Newburger JW, Ashouri N, McElhinney DB, Burns JC, Whitin JC, Cohen HJ, Tremoulet AH. Multicentre validation of a computer-based tool for differentiation of acute Kawasaki disease from clinically similar febrile illnesses. Arch Dis Child. 2020 Aug;105(8):772-777. PubMed PMID: 32139365
• Barnes M, Youngkin E, Zipprich J, Bilski K, Gregory CJ, Dominguez SR, Mumm E, McMahon M, Como-Sabetti K, Lynfield R, Chochua S, Onukwube J, Arvay M, Herlihy R. Notes from the Field: Increase in Pediatric Invasive Group A Streptococcus Infections - Colorado and Minnesota, October-December 2022. MMWR Morb Mortal Wkly Rep. 2023 Mar 10;72(10):265-267. PubMed PMID: 36893049
• Searns JB, Rice JD, Bertin KB, Birkholz M, Barganier LB, Creech CB, Downes KJ, Hubbell BB, Kronman MP, Rolsma SL, Sydney GI, O'Leary ST, Parker SK, Dominguez SR. Using Administrative Billing Codes to Identify Acute Musculoskeletal Infections in Children. Hosp Pediatr. 2023 Feb 1;13(2):182-195. PubMed PMID: 36601701
• Dodson DS, Dominguez SR, MacBrayne CE, Williams MC, Parker SK. Vancomycin-Nonsusceptible Enterococci Mediated by vanC at a Large Children's Hospital: Prevalence, Susceptibility, and Impact on Care of Enterococcal Bacteremia. Open Forum Infect Dis. 2020 May;7(5):ofaa160. PubMed PMID: 32478121
• Boster JM, Dominguez SR, Messacar K, Adams M, Weinberg A, Black JO, Feldman AG. Acute Liver Failure in a Child With Adenovirus Detected by PCR in the Explanted Liver. Pediatrics. 2023 Feb 1;151(2). PubMed PMID: 36691756
• Messacar K, Gaensbauer JT, Birkholz M, Palmer C, Todd JK, Tyler KL, Dominguez SR. Impact of FilmArray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period. Diagn Microbiol Infect Dis. 2020 Aug;97(4):115085. PubMed PMID: 32559588
• Jone PN, Korst A, Karimpour-Fard A, Thomas T, Dominguez SR, Heizer H, Anderson MS, Glode MP, Sucharov CC, Miyamoto SD. Circulating microRNAs differentiate Kawasaki Disease from infectious febrile illnesses in childhood. J Mol Cell Cardiol. 2020 Sep;146:12-18. PubMed PMID: 32634388
• Gould CV, Messacar K, Dominguez SR, Panella A, Tobolowsky F, Fischer M. Evaluation for Arboviral Infection Among Children Hospitalized in Colorado With Aseptic Meningitis and Encephalitis. Pediatr Infect Dis J. 2020 Nov;39(11):e382-e384. PubMed PMID: 32773665
• DomBourian MG, Annen K, Huey L, Andersen G, Merkel PA, Jung S, Dominguez SR, Knight V. Analysis of COVID-19 convalescent plasma for SARS-CoV-2 IgG using two commercial immunoassays. J Immunol Methods. 2020 Nov;486:112837. PubMed PMID: 32828791
• Shane AL, Sato AI, Kao C, Adler-Shohet FC, Vora SB, Auletta JJ, Nachman S, Raabe VN, Inagaki K, Akinboyo IC, Woods C, Alsulami AO, Kainth MK, Santos RP, Espinosa CM, Burns JE, Cunningham CK, Dominguez SR, Martinez BL, Zhu F, Crews J, Kitano T, Saiman L, Kotloff K. A Pediatric Infectious Diseases Perspective of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Novel Coronavirus Disease 2019 (COVID-19) in Children. J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):596-608. PubMed PMID: 32840614
• Williams MC, Dominguez SR, Prinzi A, Lee K, Parker SK. Reliability of mecA in Predicting Phenotypic Susceptibilities of Coagulase-Negative Staphylococci and Staphylococcus aureus . Open Forum Infect Dis. 2020 Dec;7(12):ofaa553. PubMed PMID: 33409329

Professional Memberships

• Christian Medical and Dental Association, Member
• American Academy of Pediatrics, Member
• Christian Community Health, Fellow
• Pediatric Infectious Disease Society, Member
• Infectious Disease Society of America, Member
• American Society of Microbiology, Member

Practice Locations

• Children's Hospital Colorado

Specialty Information

• Pediatric Infectious Diseases, Board Certification (2007)
• Pediatrics, Board Certification (2003)

• Child and Teen Health
• Infections