Peter Hackett, MD

Assistant Clinical Professor, Medicine-Pulmonary Sciences & Critical Care

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Fellowships
  • University of Colorado (University Hospital) Program, Cardiovascular Pulmonary Research (1978)
Department
Medicine-Pulmonary Sciences & Critical Care

Recognitions

  • The Grover Award, American Thoraicic Society (2019)
    for recognized quality research on the pulmonary circulation

Publications

  • Luks AM, Beidleman BA, Freer L, Grissom CK, Keyes LE, McIntosh SE, Rodway GW, Schoene RB, Zafren K, Hackett PH. Wilderness Medical Society Clinical Practice Guidelines for the Prevention, Diagnosis, and Treatment of Acute Altitude Illness: 2024 Update. Wilderness Environ Med. 2024 Mar;35(1_suppl):2S-19S. PubMed PMID: 37833187
  • McIntosh SE, Freer L, Grissom CK, Rodway GW, Giesbrecht GG, McDevitt M, Imray CH, Johnson EL, Pandey P, Dow J, Hackett PH. Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2024 Update. Wilderness Environ Med. 2024 Jun;35(2):183-197. PubMed PMID: 38577729
  • Burtscher J, Swenson ER, Hackett PH, Millet GP, Burtscher M. Flying to high-altitude destinations: Is the risk of acute mountain sickness greater?. J Travel Med. 2023 Jun 23;30(4). PubMed PMID: 36694981
  • Luks AM, Hackett PH. Medical Conditions and High-Altitude Travel. Reply. N Engl J Med. 2022 May 12;386(19):1866-1867. PubMed PMID: 35544405
  • Luks AM, Hackett PH. Medical Conditions and High-Altitude Travel. N Engl J Med. 2022 Jan 27;386(4):364-373. PubMed PMID: 35081281
  • Luks AM, Freer L, Grissom CK, McIntosh SE, Schoene RB, Swenson ER, Hackett PH. COVID-19 Lung Injury is Not High Altitude Pulmonary Edema. High Alt Med Biol. 2020 Jun;21(2):192-193. PubMed PMID: 32281877
  • Berger MM, Hackett PH, Bärtsch P. No Relevant Analogy Between COVID-19 and Acute Mountain Sickness. High Alt Med Biol. 2020 Dec;21(4):315-318. PubMed PMID: 32970479
  • Rice ES, Koren S, Rhie A, Heaton MP, Kalbfleisch TS, Hardy T, Hackett PH, Bickhart DM, Rosen BD, Ley BV, Maurer NW, Green RE, Phillippy AM, Petersen JL, Smith TPL. Continuous chromosome-scale haplotypes assembled from a single interspecies F1 hybrid of yak and cattle. Gigascience. 2020 Apr 1;9(4). PubMed PMID: 32242610
  • Hackett PH, Yarnell PR, Weiland DA, Reynard KB. Acute and Evolving MRI of High-Altitude Cerebral Edema: Microbleeds, Edema, and Pathophysiology. AJNR Am J Neuroradiol. 2019 Mar;40(3):464-469. PubMed PMID: 30679208
  • Roach RC, Hackett PH, Oelz O, Bärtsch P, Luks AM, MacInnis MJ, Baillie JK. The 2018 Lake Louise Acute Mountain Sickness Score. High Alt Med Biol. 2018 Mar;19(1):4-6. PubMed PMID: 29583031
  • Roach RC, Wagner PD, Ainslie PN, Hackett PH. Translation in Progress: Hypoxia 2017. J Appl Physiol (1985). 2017 Oct 1;123(4):922-925. PubMed PMID: 29025903
  • Cauchy E, Davis CB, Pasquier M, Meyer EF, Hackett PH. A New Proposal for Management of Severe Frostbite in the Austere Environment. Wilderness Environ Med. 2016 Mar;27(1):92-9. PubMed PMID: 26948558
  • Keyes LE, Hackett PH, Luks AM. Outdoor Activity and High Altitude Exposure During Pregnancy: A Survey of 459 Pregnancies. Wilderness Environ Med. 2016 Jun;27(2):227-35. PubMed PMID: 27291703
  • Lawley JS, Levine BD, Williams MA, Malm J, Eklund A, Polaner DM, Subudhi AW, Hackett PH, Roach RC. Cerebral spinal fluid dynamics: effect of hypoxia and implications for high-altitude illness. J Appl Physiol (1985). 2016 Jan 15;120(2):251-62. PubMed PMID: 26494441
  • Zafren K, Giesbrecht GG, Danzl DF, Brugger H, Sagalyn EB, Walpoth B, Weiss EA, Auerbach PS, McIntosh SE, Némethy M, McDevitt M, Dow J, Schoene RB, Rodway GW, Hackett PH, Bennett BL, Grissom CK. Hypothermia Evidence, Afterdrop, and Guidelines. Wilderness Environ Med. 2015 Sep;26(3):439-41. PubMed PMID: 25840910
  • Roach RC, Wagner PD, Kayser B, Hackett PH. Translation in progress: Hypoxia 2015. J Appl Physiol (1985). 2015 Nov 15;119(10):1127-8. PubMed PMID: 26338459
  • Roach RC, Wagner PD, Hackett PH. Translation in progress: hypoxia. J Appl Physiol (1985). 2014 Apr 1;116(7):835-6. PubMed PMID: 24557798
  • Patz DS, Patz MD, Hackett PH. Dead space mask eliminates central apnea at altitude. High Alt Med Biol. 2013 Jun;14(2):168-74. PubMed PMID: 23795738
  • Kelly TE, Hackett PH. Acetazolamide and sulfonamide allergy: a not so simple story. High Alt Med Biol. 2010 Winter;11(4):319-23. PubMed PMID: 21190500
  • Hackett PH. Caffeine at high altitude: java at base cAMP. High Alt Med Biol. 2010 Spring;11(1):13-7. PubMed PMID: 20367483
  • Leadbetter G, Keyes LE, Maakestad KM, Olson S, Tissot van Patot MC, Hackett PH. Ginkgo biloba does--and does not--prevent acute mountain sickness. Wilderness Environ Med. 2009 Spring;20(1):66-71. PubMed PMID: 19364166
  • van Patot MC, Keyes LE, Leadbetter G 3rd, Hackett PH. Ginkgo biloba for prevention of acute mountain sickness: does it work?. High Alt Med Biol. 2009 Spring;10(1):33-43. PubMed PMID: 19278351
  • van Patot MC, Leadbetter G 3rd, Keyes LE, Maakestad KM, Olson S, Hackett PH. Prophylactic low-dose acetazolamide reduces the incidence and severity of acute mountain sickness. High Alt Med Biol. 2008 Winter;9(4):289-93. PubMed PMID: 19115912
  • Baumgartner RW, Siegel AM, Hackett PH. Going high with preexisting neurological conditions. High Alt Med Biol. 2007 Summer;8(2):108-16. PubMed PMID: 17584004
  • Hackett PH, Roach RC. High altitude cerebral edema. High Alt Med Biol. 2004 Summer;5(2):136-46. PubMed PMID: 15265335
  • Gallagher SA, Hackett PH. High-altitude illness. Emerg Med Clin North Am. 2004 May;22(2):329-55, viii. PubMed PMID: 15163571
  • Roach RC, Hackett PH. Frontiers of hypoxia research: acute mountain sickness. J Exp Biol. 2001 Sep;204(Pt 18):3161-70. PubMed PMID: 11581330
  • Hackett PH, Roach RC. High-altitude illness. N Engl J Med. 2001 Jul 12;345(2):107-14. PubMed PMID: 11450659
  • Hackett PH. Subarachnoid cyst and ascent to high altitude--a problem?. High Alt Med Biol. 2000 Winter;1(4):337-9. PubMed PMID: 11256470
  • Yarnell PR, Heit J, Hackett PH. High-altitude cerebral edema (HACE): the Denver/Front Range experience. Semin Neurol. 2000;20(2):209-17. PubMed PMID: 10946741
  • Hackett PH. The cerebral etiology of high-altitude cerebral edema and acute mountain sickness. Wilderness Environ Med. 1999 Summer;10(2):97-109. PubMed PMID: 10442158
  • Hackett PH. High altitude cerebral edema and acute mountain sickness. A pathophysiology update. Adv Exp Med Biol. 1999;474:23-45. PubMed PMID: 10634991
  • Hackett PH, Yarnell PR, Hill R, Reynard K, Heit J, McCormick J. High-altitude cerebral edema evaluated with magnetic resonance imaging: clinical correlation and pathophysiology. JAMA. 1998 Dec 9;280(22):1920-5. PubMed PMID: 9851477
  • Roach RC, Greene ER, Schoene RB, Hackett PH. Arterial oxygen saturation for prediction of acute mountain sickness. Aviat Space Environ Med. 1998 Dec;69(12):1182-5. PubMed PMID: 9856544
  • Hackett PH, Roach RC, Hartig GS, Greene ER, Levine BD. The effect of vasodilators on pulmonary hemodynamics in high altitude pulmonary edema: a comparison. Int J Sports Med. 1992 Oct;13 Suppl 1:S68-71. PubMed PMID: 1483798
  • Grissom CK, Roach RC, Sarnquist FH, Hackett PH. Acetazolamide in the treatment of acute mountain sickness: clinical efficacy and effect on gas exchange. Ann Intern Med. 1992 Mar 15;116(6):461-5. PubMed PMID: 1739236
  • Swenson ER, Leatham KL, Roach RC, Schoene RB, Mills WJ Jr, Hackett PH. Renal carbonic anhydrase inhibition reduces high altitude sleep periodic breathing. Respir Physiol. 1991 Dec;86(3):333-43. PubMed PMID: 1788493
  • Levine BD, Grayburn PA, Voyles WF, Greene ER, Roach RC, Hackett PH. Intracardiac shunting across a patent foramen ovale may exacerbate hypoxemia in high-altitude pulmonary edema. Ann Intern Med. 1991 Apr 1;114(7):569-70. PubMed PMID: 2001089
  • Schoene RB, Roach RC, Hackett PH, Sutton JR, Cymerman A, Houston CS. Operation Everest II: ventilatory adaptation during gradual decompression to extreme altitude. Med Sci Sports Exerc. 1990 Dec;22(6):804-10. PubMed PMID: 2287258
  • Schoene RB, Roach RC, Lahiri S, Peters RM Jr, Hackett PH, Santolaya R. Increased diffusion capacity maintains arterial saturation during exercise in the Quechua Indians of Chilean Altiplano. Am J Hum Biol. 1990;2(6):663-668. PubMed PMID: 28520127
  • Hackett PH. Carbon dioxide breathing and mountain sickness. Lancet. 1989 Feb 4;1(8632):272-3. PubMed PMID: 2563429
  • Hackett PH, Roach RC, Wood RA, Foutch RG, Meehan RT, Rennie D, Mills WJ Jr. Dexamethasone for prevention and treatment of acute mountain sickness. Aviat Space Environ Med. 1988 Oct;59(10):950-4. PubMed PMID: 3190622
  • Turner WA, Cohen MA, Moore S, Spengler JD, Hackett PH. Carbon monoxide exposure in mountaineers on Denali. Alaska Med. 1988 May-Jun;30(3):85-90. PubMed PMID: 3400837
  • Hackett PH, Roach RC, Schoene RB, Harrison GL, Mills WJ Jr. Abnormal control of ventilation in high-altitude pulmonary edema. J Appl Physiol (1985). 1988 Mar;64(3):1268-72. PubMed PMID: 3366741
  • Schoene RB, Swenson ER, Pizzo CJ, Hackett PH, Roach RC, Mills WJ Jr, Henderson WR Jr, Martin TR. The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema. J Appl Physiol (1985). 1988 Jun;64(6):2605-13. PubMed PMID: 3403445
  • Hackett PH, Roach RC. Medical therapy of altitude illness. Ann Emerg Med. 1987 Sep;16(9):980-6. PubMed PMID: 3307558
  • Hackett PH, Roach RC, Harrison GL, Schoene RB, Mills WJ Jr. Respiratory stimulants and sleep periodic breathing at high altitude. Almitrine versus acetazolamide. Am Rev Respir Dis. 1987 Apr;135(4):896-8. PubMed PMID: 3565935
  • Hackett PH, Bertman J, Rodriguez G, Tenney J. Pulmonary edema fluid protein in high-altitude pulmonary edema. JAMA. 1986 Jul 4;256(1):36. PubMed PMID: 3712705
  • Schoene RB, Hackett PH, Henderson WR, Sage EH, Chow M, Roach RC, Mills WJ Jr, Martin TR. High-altitude pulmonary edema. Characteristics of lung lavage fluid. JAMA. 1986 Jul 4;256(1):63-9. PubMed PMID: 3012134
  • Sarnquist FH, Schoene RB, Hackett PH, Townes BD. Hemodilution of polycythemic mountaineers: effects on exercise and mental function. Aviat Space Environ Med. 1986 Apr;57(4):313-7. PubMed PMID: 3964159
  • Hackett PH, Schoene RB, Winslow RM, Peters RM Jr, West JB. Acetazolamide and exercise in sojourners to 6,300 meters--a preliminary study. Med Sci Sports Exerc. 1985 Oct;17(5):593-7. PubMed PMID: 4068966
  • Schoene RB, Roach RC, Hackett PH, Harrison G, Mills WJ Jr. High altitude pulmonary edema and exercise at 4,400 meters on Mount McKinley. Effect of expiratory positive airway pressure. Chest. 1985 Mar;87(3):330-3. PubMed PMID: 3882350
  • Hackett PH, Rodriguez G, Roach RC. Clove cigarettes and high-altitude pulmonary edema. JAMA. 1985 Jun 28;253(24):3551-2. PubMed PMID: 3999337
  • Schoene RB, Lahiri S, Hackett PH, Peters RM Jr, Milledge JS, Pizzo CJ, Sarnquist FH, Boyer SJ, Graber DJ, Maret KH. Relationship of hypoxic ventilatory response to exercise performance on Mount Everest. J Appl Physiol Respir Environ Exerc Physiol. 1984 Jun;56(6):1478-83. PubMed PMID: 6735806
  • West JB, Boyer SJ, Graber DJ, Hackett PH, Maret KH, Milledge JS, Peters RM Jr, Pizzo CJ, Samaja M, Sarnquist FH. Maximal exercise at extreme altitudes on Mount Everest. J Appl Physiol Respir Environ Exerc Physiol. 1983 Sep;55(3):688-98. PubMed PMID: 6415008
  • West JB, Hackett PH, Maret KH, Milledge JS, Peters RM Jr, Pizzo CJ, Winslow RM. Pulmonary gas exchange on the summit of Mount Everest. J Appl Physiol Respir Environ Exerc Physiol. 1983 Sep;55(3):678-87. PubMed PMID: 6415007
  • West JB, Hackett PH, Maret KH, Milledge JS, Peters RM Jr, Pizzo CJ, Winslow RM. Human physiology on the summit of Mount Everest. Trans Assoc Am Physicians. 1982;95:63-70. PubMed PMID: 7182987
  • Hackett PH, Rennie D, Hofmeister SE, Grover RF, Grover EB, Reeves JT. Fluid retention and relative hypoventilation in acute mountain sickness. Respiration. 1982;43(5):321-9. PubMed PMID: 6815746
  • Hackett PH, Rennie D, Grover RF, Reeves JT. Acute mountain sickness and the edemas of high altitude: a common pathogenesis?. Respir Physiol. 1981 Dec;46(3):383-90. PubMed PMID: 7323495
  • Hackett PH, Reeves JT, Reeves CD, Grover RF, Rennie D. Control of breathing in Sherpas at low and high altitude. J Appl Physiol Respir Environ Exerc Physiol. 1980 Sep;49(3):374-9. PubMed PMID: 7204157
  • Hackett PH, Creagh CE, Grover RF, Honigman B, Houston CS, Reeves JT, Sophocles AM, Van Hardenbroek M. High-altitude pulmonary edema in persons without the right pulmonary artery. N Engl J Med. 1980 May 8;302(19):1070-3. PubMed PMID: 7366625
  • Hackett PH. Acute mountain sickness - the clinical approach. Adv Cardiol. 1980;27:6-10. PubMed PMID: 7446294
  • Hackett PH, Rennie D. Rales, peripheral edema, retinal hemorrhage and acute mountain sickness. Am J Med. 1979 Aug;67(2):214-8. PubMed PMID: 463925
  • Sutton JR, Houston CS, Mansell AL, McFadden MD, Hackett PM, Rigg JR, Powles AC. Effect of acetazolamide on hypoxemia during sleep at high altitude. N Engl J Med. 1979 Dec 13;301(24):1329-31. PubMed PMID: 503151
  • Hackett PH, Rennie D. Avoiding mountain sickness. Lancet. 1978 Oct 28;2(8096):938. PubMed PMID: 81945
  • Bangham CR, Hackett PH. Effects of high altitude on endocrine function in the Sherpas of Nepal. J Endocrinol. 1978 Oct;79(1):147-8. PubMed PMID: 712313
  • Hackett PH, Forsling ML, Milledge J, Rennie D. Release of vasopressin in man at altitude. Horm Metab Res. 1978 Nov;10(6):571. PubMed PMID: 744584
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Professional Memberships

  • International Society for Mountain Medicine, past president
  • Wilderness Medical Society, Founding Member
  • Himalayan Rescue Association, former medicall director
  • American Thoracic Society, Honoree
  • International Society for travel Medicine, Emeritus
Clinical Interests
Medical Problems of High Altitude Altitude Illness Frostbite Mountain Medicine

Personal Interests
Environmental causes, mountaineering, hiking, skiing, wildlife, rewilding

Volunteer Activities
Himalayan Rescue Association, former medical director International Society for Mountain Medicine, former president Wilderness Medical Society

Public Speaking
Yes
High altitude medicine, altitude illness, living at high altitude, mountain medicine and rescue, high altitude physiology

School of Medicine

CU Anschutz

Fitzsimons Building

13001 East 17th Place

Campus Box C290

Aurora, CO 80045

303.724.5375

School
General
Students