Michael Bristow, MD, PhD
Professor, Medicine-Cardiology

Photo
Medical School:
  • MD, University of Illinois College of Medicine (1970)
Graduate School :
  • PhD, University of Illinois, Chicago (1971)
Internship:
  • Stanford University Program (1972)
Residency:
  • Stanford University Program, Internal Medicine (1977)
Fellowships:
  • Stanford Hospital and Clinics Program, General Cardiology (1978)
Languages: English
Department: Medicine-Cardiology

Professional Titles

  • Professor of Medicine, Cardiology
  • Director, Pharmacogenomics, CU-CVI

Recognition & Awards

  • Guest Editor in Chief, JACC: Basic to Translational Science, JACC (2020)

Publications

  • Annex BH, Bristow MR, Frangogiannis NG, Kelly DP, Kontaridis M, Libby P, MacLellan WR, McNamara CA, Mann DL, Pitt GS, Sipido KR. JACC: Basic to Translational Science Top Reviewers 2023: With Appreciation and Gratitude. JACC Basic Transl Sci. 2024 Jan;9(1):161. PubMed PMID: 38362353
  • Diamond MG, Fiuzat M, Mentz RJ, Lala-Trindade A, Whellan DJ, Walsh MN, Costanzo MR, Yehya A, Desvigne-Nickens P, Malik F, O'Connor CM, Bristow MR. Rewarding Site-Based Research: A Step Toward Improving the Ecosystem of Heart Failure Clinical Trials. JACC Heart Fail. 2024 Jan;12(1):226-228. PubMed PMID: 37804314
  • Fleming TR, Wittes J, Fiuzat M, Bristow MR, Frank W. Rockhold FW, Connor JT, Saville BR, Claggett B, Isabella Cavagna I, Abraham WT, Cook TD, 13, Lindenfeld J, O’Connor CM, , David L DeMets DL, on Behalf of the Heart Failure Collaboratory. Training the next generation of Data Monitoring Committee Members: An initiative of the Heart Failure Collaboratory. In press. 2024.
  • Rubino M, Travers JG, Headrick AL, Enyart BT, Lemieux ME, Cavasin MA, Schwisow JA, Hardy EJ, Kaltenbacher KJ, Felisbino MB, Jonas E, Ambardekar AV, Bristow MR, Koch KA, McKinsey TA. Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart. Circ Res. 2023 Jan 6;132(1):10-29. PubMed PMID: 36475698
  • Martin TG, Pak H, Gerhard GS, Merali S, Merali C, Lemster B, Dubey P, McTiernan CF, Bristow MR, Feldman AM, Kirk JA. Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 Variants. J Am Heart Assoc. 2023 Dec 19;12(24):e029938. PubMed PMID: 38108245
  • Dimond MG, Ibrahim NE, Fiuzat M, McMurray JJV, Lindenfeld J, Ahmad T, Bozkurt B, Bristow MR, Butler J, Carson PE, Felker GM, Jessup M, Murillo J, Kondo T, Solomon SD, Abraham WT, O'Connor CM, Psotka MA. Left Ventricular Ejection Fraction and the Future of Heart Failure Phenotyping. JACC Heart Fail. 2023 Nov 28. [Epub ahead of print] PubMed PMID: 38099892
  • Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M. How carvedilol does not activate ß(2)-adrenoceptors. Nat Commun. 2023 Nov 30;14(1):7866. PubMed PMID: 38036531
  • Martin TG, Juarros MA, Cleveland JC Jr, Bristow MR, Ambardekar AV, Buttrick PM, Leinwand LA. Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy. JACC Basic Transl Sci. 2023 Sep;8(9):1043-1056. PubMed PMID: 37791310
  • Tatman PD, Kao DP, Chatfield KC, Carroll IA, Wagner JA, Jonas ER, Sucharov CC, Port JD, Lowes BD, Minobe WA, Huebler SP, Karimpour-Fard A, Rodriguez EM, Liggett SB, Bristow MR. An extensive ß1-adrenergic receptor gene signaling network regulates molecular remodeling in dilated cardiomyopathies. JCI Insight. 2023 Aug 22;8(16). PubMed PMID: 37606047
  • Hess CN, Hsia J, Carroll IA, Nehler MR, Ruf W, Morrow DA, Nicolau JC, Berwanger O, Szarek M, Capell WH, Johri S, Pursley MS, Gupta R, Meehan PS, Franchi F, Effron MB, Marshall D, Graybill CA, Huebler SP, Keuer T, Bristow MR, Bonaca MP. Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial. Arterioscler Thromb Vasc Biol. 2023 Aug;43(8):1572-1582. PubMed PMID: 37381988
  • Koupenova M, Chung MK, Bristow MR. COVID-19 and the Cardiovascular System: Requiem for a Medical Minotaur. Circ Res. 2023 May 12;132(10):1255-1258. PubMed PMID: 37167357
  • Altman NL, Berning AA, Mann SC, Quaife RA, Gill EA, Auerbach SR, Campbell TB, Bristow MR. Vaccination-Associated Myocarditis and Myocardial Injury. Circ Res. 2023 May 12;132(10):1338-1357. PubMed PMID: 37167355
  • Chevalier P, Roy P, Bessière F, Morel E, Ankou B, Morgan G, Halder I, London B, Minobe WA, Slavov D, Delinière A, Bochaton T, Paganelli F, Lesavre N, Boiteux C, Mansourati J, Maury P, Clerici G, Winum PF, Huebler SP, Carroll IA, Bristow MR. Impact of Neuroeffector Adrenergic Receptor Polymorphisms on Incident Ventricular Fibrillation During Acute Myocardial Ischemia. J Am Heart Assoc. 2023 Mar 21;12(6):e025368. PubMed PMID: 36926933
  • Annex BH, Bristow MR, Frangogiannis NG, Kelly DP, Kontaridis M, Libby P, MacLellan WR, McNamara CA, Mann DL, Pitt GS, Sipido KR. JACC: Basic to Translational Science Top Reviewers 2022: With Appreciation and Gratitude. JACC Basic Transl Sci. 2023 Feb;8(2):236. PubMed PMID: 36908670
  • Rubino M, Travers JG, Headrick AL, Enyart BT, Lemieux ME, Cavasin MA, Schwisow JA, Hardy EJ, Kaltenbacher KJ, Felisbino MB, Jonas E, Ambardekar AV, Bristow MR, Koch KA, McKinsey TA. Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart. Circ Res. 2023 Jan 6;132(1):10-29. PubMed PMID: 36475698
  • Altman NL, Berning AA, Saxon CE, Adamek KE, Wagner JA, Slavov D, Quaife RA, Gill EA, Minobe WA, Jonas ER, Carroll IA, Huebler SP, Raines J, Messenger JC, Ambardekar AV, Mestroni L, Rosenberg RM, Rove J, Campbell TB, Bristow MR. Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination. JACC Basic Transl Sci. 2023 Feb;8(2):124-137. PubMed PMID: 36281440
  • Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow MR, Gonzalez-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. Circulation. 2022 Feb 4. [Epub ahead of print] PubMed PMID: 35114812
  • Hess CN, Capell WH, Bristow MR, Ruf W, Szarek M, Morrow DA, Nicolau JC, Graybill CA, Marshall D, Hsia J, Bonaca MP. Rationale and design of a study to assess the safety and efficacy of rNAPc2 in COVID-19: the Phase 2b ASPEN-COVID-19 trial. Am Heart J. 2022 Jan 2;246:136-143. [Epub ahead of print] PubMed PMID: 34986394
  • Gao S, Mumme-Monheit A, Chen SN, Spector EB, Slavov D, Baralle FE, Bristow MR, Mestroni L, Taylor MRG. An LMNA synonymous variant associated with severe dilated cardiomyopathy: Case report. Am J Med Genet A. 2022 Feb;188(2):600-605. PubMed PMID: 34652067
  • Altman NL, Berning AA, Saxon CE, Adamek KE, Wagner JA, Slavov D, Quaife RA, Gill EA, Minobe WA, Jonas ER, Carroll IA, Huebler SP, Raines J, Messenger JC, Ambardekar AV, Mestroni L, Rosenberg RM, Rove J, Campbell TB, Bristow MR. Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination. JACC Basic Transl Sci. 2022 Oct 19. [Epub ahead of print] PubMed PMID: 36281440
  • Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe KC, Bristow MR, Buttrick PM, Song K. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 Aug 30;146(9):699-714. PubMed PMID: 35862102
  • Cleland JGF, Bristow MR, Freemantle N, Olshansky B, Gras D, Saxon L, Tavazzi L, Boehmer J, Ghio S, Feldman AM, Daubert JC, de Mets D. The effect of cardiac resynchronization without a defibrillator on morbidity and mortality: an individual patient data meta-analysis of COMPANION and CARE-HF. Eur J Heart Fail. 2022 Jun;24(6):1080-1090. PubMed PMID: 35490339
  • Annex BH, Bristow MR, Frangogiannis NG, Kelly DP, Kontaridis MI, Libby P, Robb MacLellan W, McNamara CA, Mann DL, Pitt GS, Sipido KR. JACC: Basic to Translational Science Top Reviewers 2021: With Appreciation. JACC Basic Transl Sci. 2022 Feb;7(2):192. PubMed PMID: 35257046
  • Bristow MR, Mann DL. Cardiac Adrenergic Activation in Heart Failure With Preserved Ejection Fraction: A Role for ß-Blockade?. JACC Basic Transl Sci. 2022 Feb;7(2):128-130. PubMed PMID: 35257039
  • Abraham WT, Piccini JP, Dufton C, Carroll IA, Healey JS, O'Connor CM, Marshall D, Aleong R, van Veldhuisen DJ, Rienstra M, Wilton SB, White M, Sauer WH, Anand IS, Huebler SP, Connolly SJ, Bristow MR. Dose-limiting, adverse event-associated bradycardia with ß-blocker treatment of atrial fibrillation in the GENETIC-AF trial. Heart Rhythm O2. 2022 Feb;3(1):40-49. PubMed PMID: 35243434
  • Chen SN, Lam CK, Wan YW, Gao S, Malak OA, Zhao SR, Lombardi R, Ambardekar AV, Bristow MR, Cleveland J, Gigli M, Sinagra G, Graw S, Taylor MRG, Wu JC, Mestroni L. Activation of PDGFRA signaling contributes to filamin C-related arrhythmogenic cardiomyopathy. Sci Adv. 2022 Feb 25;8(8):eabk0052. PubMed PMID: 35196083
  • Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow MR, González-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. Circulation. 2022 Apr 19;145(16):1218-1233. PubMed PMID: 35114812
  • Hess CN, Capell WH, Bristow MR, Ruf W, Szarek M, Morrow DA, Nicolau JC, Graybill CA, Marshall D, Hsia J, Bonaca MP. Rationale and design of a study to assess the safety and efficacy of rNAPc2 in COVID-19: the Phase 2b ASPEN-COVID-19 trial. Am Heart J. 2022 Apr;246:136-143. PubMed PMID: 34986394
  • Gao S, Mumme-Monheit A, Chen SN, Spector EB, Slavov D, Baralle FE, Bristow MR, Mestroni L, Taylor MRG. An LMNA synonymous variant associated with severe dilated cardiomyopathy: Case report. Am J Med Genet A. 2022 Feb;188(2):600-605. PubMed PMID: 34652067
  • Hailu FT, Karimpour-Fard A, Toni LS, Bristow MR, Miyamoto SD, Stauffer BL, Sucharov CC. Integrated analysis of miRNA-mRNA interaction in pediatric dilated cardiomyopathy. Pediatr Res. 2022 Jul;92(1):98-108. PubMed PMID: 34012027
  • Leopold JA, Kawut SM, Aldred MA, Archer SL, Benza RL, Bristow MR, Brittain EL, Chesler N, DeMan FS, Erzurum SC, Gladwin MT, Hassoun PM, Hemnes AR, Lahm T, Lima JAC, Loscalzo J, Maron BA, Rosa LM, Newman JH, Redline S, Rich S, Rischard F, Sugeng L, Tang WHW, Tedford RJ, Tsai EJ, Ventetuolo CE, Zhou Y, Aggarwal NR, Xiao L. Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases: A National Heart, Lung, and Blood Institute Workshop. Circ Heart Fail. 2021 Jun;14(6). PubMed PMID: 34422205
  • Piccini JP, Dufton C, Carroll IA, Healey JS, Abraham WT, Khaykin Y, Aleong R, Krueger SK, Sauer WH, Wilton SB, Rienstra M, van Veldhuisen DJ, Anand IS, White M, Camm AJ, Ziegler PD, Marshall D, Bristow MR, Connolly SJ. Bucindolol Decreases Atrial Fibrillation Burden in Patients With Heart Failure and the ADRB1 Arg389Arg Genotype. Circ Arrhythm Electrophysiol. 2021 Aug;14(8):e009591. PubMed PMID: 34270905
  • Woulfe KC, Jeffrey DA, Pires Da Silva J, Wilson CE, Mahaffey JH, Lau E, Slavov D, Hailu F, Karimpour-Fard A, Dockstader K, Bristow MR, Stauffer BL, Miyamoto SD, Sucharov CC. Serum response factor deletion 5 regulates phospholamban phosphorylation and calcium uptake. J Mol Cell Cardiol. 2021 Oct;159:28-37. PubMed PMID: 34139234
  • Hailu FT, Karimpour-Fard A, Toni LS, Bristow MR, Miyamoto SD, Stauffer BL, Sucharov CC. Integrated analysis of miRNA-mRNA interaction in pediatric dilated cardiomyopathy. Pediatr Res. 2021 May 19. [Epub ahead of print] PubMed PMID: 34012027
  • Das M, Bristow MR, Chung MK. The Essential Vulnerability of Human Cardiac Myocytes to SARS-CoV-2. JACC Basic Transl Sci. 2021 Apr;6(4):346-349. PubMed PMID: 33997520
  • Doran B, Mei C, Varosy PD, Kao DP, Saxon LA, Feldman AM, DeMets D, Bristow MR. The Addition of a Defibrillator to Resynchronization Therapy Decreases Mortality in Patients With Nonischemic Cardiomyopathy. JACC Heart Fail. 2021 Jun;9(6):439-449. PubMed PMID: 33992570
  • Chung MK, Zidar DA, Bristow MR, Cameron SJ, Chan T, Harding CV 3rd, Kwon DH, Singh T, Tilton JC, Tsai EJ, Tucker NR, Barnard J, Loscalzo J. COVID-19 and Cardiovascular Disease: From Bench to Bedside. Circ Res. 2021 Apr 16;128(8):1214-1236. PubMed PMID: 33856918
  • Knight WE, Cao Y, Lin YH, Chi C, Bai B, Sparagna GC, Zhao Y, Du Y, Londono P, Reisz JA, Brown BC, Taylor MRG, Ambardekar AV, Cleveland JC Jr, McKinsey TA, Jeong MY, Walker LA, Woulfe KC, D'Alessandro A, Chatfield KC, Xu H, Bristow MR, Buttrick PM, Song K. Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy. Stem Cell Reports. 2021 Mar 9;16(3):519-533. PubMed PMID: 33636116
  • Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53. J Mol Cell Cardiol. 2020 Feb;139:124-134. PubMed PMID: 31958463
  • O'Connor CM, Bristow MR. Changing U.S. Heart Failure Research Culture: Part 2-Recognizing Frontline Investigators and Coordinators. JACC Heart Fail. 2020 Dec;8(12):1050-1051. PubMed PMID: 33272381
  • Bristow MR, Zisman LS, Altman NL, Gilbert EM, Lowes BD, Minobe WA, Slavov D, Schwisow JA, Rodriguez EM, Carroll IA, Keuer TA, Buttrick PM, Kao DP. Dynamic Regulation of SARS-Cov-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium. JACC Basic Transl Sci. 2020 Sep;5(9):871-883. PubMed PMID: 32838074
  • Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53. J Mol Cell Cardiol. 2020 Feb;139:124-134. PubMed PMID: 31958463
  • Piccini JP, MD, Healey JS, Abraham WT, ……Bristow MR, Connolly SJ. Pharmacogenomic guided beta-blocker therapy with bucindolol reduces atrial fibrillation burden compared to metoprolol succinate: The GENETIC-AF Trial. HRS 2020.
  • Healey JS, Piccini JP, Abraham WT, ……Bristow MR, Connolly SJ. Impact of pharmacogenetic-guided bucindolol versus metoprolol succinate on the overall burden of clinical events in patients with atrial fibrillation and heart failure: The GENETIC-AF Trial. HRS 2020.
  • Abraham WT, Bristow MR, Piccini JP,………..Dufton C, Connolly SJ. Bucindolol is associated with a lower Incidence of dose limiting bradycardia in heart failure patients with atrial fibrillation: The GENETIC-AF Trial. HRS 2020.
  • Sucharov CC, Nakano SJ, Slavov D, Schwisow JA, Rodriguez E, Nunley K, Medway A, Stafford N, Nelson P, McKinsey TA, Movsesian M, Minobe W, Carroll IA, Taylor MRG, Bristow MR. A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium. J Am Coll Cardiol. 2019 Mar 19;73(10):1173-1184. PubMed PMID: 30871701
  • Piccini JP, Abraham WT, Dufton C, Carroll IA, Healey JS, van Veldhuisen DJ, Sauer WH, Anand IS, White M, Wilton SB, Aleong R, Rienstra M, Krueger SK, Ayala-Paredes F, Khaykin Y, Merkely B, Miloradovic V, Wranicz JK, Ilkhanoff L, Ziegler PD, Davis G, Emery LL, Marshall D, Kao DP, Bristow MR, Connolly SJ. Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population: The GENETIC-AF Trial. JACC Heart Fail. 2019 Jul;7(7):586-598. PubMed PMID: 31042551
  • Shamoun F, De Marco T, DeMets D, Mei C, Lindenfeld J, Saxon LA, Boehmer JP, Leigh J, Yong P, Feldman AM, Bristow MR. Impact of Degree of Left Ventricular Remodeling on Clinical Outcomes From Cardiac Resynchronization Therapy. JACC Heart Fail. 2019 Apr;7(4):281-290. PubMed PMID: 30738980
  • Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR. Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance. PLoS One. 2019;14(10):e0224389. PubMed PMID: 31639152
  • Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR. Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance. PLoS One. 2019;14(8):e0221519. PubMed PMID: 31469842
  • Sweet ME, Cocciolo A, Slavov D, Jones KL, Sweet JR, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure. BMC Genomics. 2018 Nov 12;19(1):812. PubMed PMID: 30419824
  • Parikh KS, Fiuzat M, Davis G, Neely M, Blain-Nelson P, Whellan DJ, Abraham WT, Adams KF Jr, Felker GM, Liggett SB, O'Connor CM, Bristow MR. Dose Response of ß-Blockers in Adrenergic Receptor Polymorphism Genotypes. Circ Genom Precis Med. 2018 Aug;11(8):e002210. PubMed PMID: 30354340
  • Myers VD, Gerhard GS, McNamara DM, Tomar D, Madesh M, Kaniper S, Ramsey FV, Fisher SG, Ingersoll RG, Kasch-Semenza L, Wang J, Hanley-Yanez K, Lemster B, Schwisow JA, Ambardekar AV, Degann SH, Bristow MR, Sheppard R, Alexis JD, Tilley DG, Kontos CD, McClung JM, Taylor AL, Yancy CW, Khalili K, Seidman JG, Seidman CE, McTiernan CF, Cheung JY, Feldman AM. Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals. JAMA Cardiol. 2018 Oct 1;3(10):929-938. PubMed PMID: 30140897
  • Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 Apr;4(4):504-514. PubMed PMID: 30067491
  • Bristow MR, Leinwand LA, Olson EN. Entrepreneurialism in the Translational Biologic Sciences: Why, How, and However. JACC Basic Transl Sci. 2018 Feb;3(1):1-8. PubMed PMID: 30062188
  • Piccini JP, Connolly SJ, Abraham WT, Healey JS, Steinberg BA, Al-Khalidi HR, Dignacco P, van Veldhuisen DJ, Sauer WH, White M, Wilton SB, Anand IS, Dufton C, Marshall DA, Aleong RG, Davis GW, Clark RL, Emery LL, Bristow MR. A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial. Am Heart J. 2018 May;199:51-58. PubMed PMID: 29754666
  • O'Connor CM, Bristow MR. Changing the Research Culture in the United States. JACC Heart Fail. 2018 Apr;6(4):344-345. PubMed PMID: 29598937
  • O'Connor CM, Psotka MA, Fiuzat M, Lindenfeld J, Abraham WT, Bristow MR, Canos D, Harrington RA, Hillebrenner M, Jessup M, Malik FI, Solomon SD, Stockbridge N, Tcheng JE, Unger EF, Whellan DJ, Zuckerman B, Califf RM. Improving Heart Failure Therapeutics Development in the United States: The Heart Failure Collaboratory. J Am Coll Cardiol. 2018 Jan 30;71(4):443-453. PubMed PMID: 29389362
  • Bristow MR. Contractile reserve and the response to cardiac resynchronization therapy. Int J Cardiol. 2018 Feb 1;252:234-235. PubMed PMID: 29249434
  • Leary PJ, Kronmal RA, Bluemke DA, Buttrick PM, Jones KL, Kao DP, Kawut SM, Krieger EV, Lima JA, Minobe W, Ralph DD, Tedford RJ, Weiss NS, Bristow MR. Histamine H(2) Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial). Am J Cardiol. 2018 Jan 15;121(2):256-261. PubMed PMID: 29191567
  • Bristow MR, Quaife RA. The adrenergic system in pulmonary arterial hypertension: bench to bedside (2013 Grover Conference series). Pulm Circ. 2015 Sep;5(3):415-23. PubMed PMID: 26401244
  • Vehlow C, Kao DP, Bristow MR, Hunter LE, Weiskopf D, Görg C. Visual analysis of biological data-knowledge networks. BMC Bioinformatics. 2015 Apr 29;16:135. PubMed PMID: 25925016
  • Fordyce CB, Roe MT, Ahmad T, Libby P, Borer JS, Hiatt WR, Bristow MR, Packer M, Wasserman SM, Braunstein N, Pitt B, DeMets DL, Cooper-Arnold K, Armstrong PW, Berkowitz SD, Scott R, Prats J, Galis ZS, Stockbridge N, Peterson ED, Califf RM. Cardiovascular drug development: is it dead or just hibernating?. J Am Coll Cardiol. 2015 Apr 21;65(15):1567-82. PubMed PMID: 25881939
  • Kao DP, Lowes BD, Gilbert EM, Minobe W, Epperson LE, Meyer LK, Ferguson DA, Volkman AK, Zolty R, Borg CD, Quaife RA, Bristow MR. Therapeutic Molecular Phenotype of ß-Blocker-Associated Reverse-Remodeling in Nonischemic Dilated Cardiomyopathy. Circ Cardiovasc Genet. 2015 Apr;8(2):270-83. PubMed PMID: 25637602
  • Hinterberg MA, Kao DP, Bristow MR, Hunter LE, Port JD, Görg C. Peax: interactive visual analysis and exploration of complex clinical phenotype and gene expression association. Pac Symp Biocomput. 2015;:419-30. PubMed PMID: 25592601
  • Hinterberg MA, Kao DP, Bristow MR, Hunter LE, Port JD, Görg C. Peax: interactive visual analysis and exploration of complex clinical phenotype and gene expression association. Pac Symp Biocomput. 2015;:419-30. PubMed PMID: 25592601
  • Bristow MR, Aleong RG. Treatment of the heart failure patient with atrial fibrillation: a major unmet need. JACC Heart Fail. 2013 Feb;1(1):29-30. PubMed PMID: 24621796
  • Aleong RG, Sauer WH, Davis G, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR. Prevention of Atrial Fibrillation by Bucindolol Is Dependent on the Beta(1)389 Arg/Gly Adrenergic Receptor Polymorphism. JACC Heart Fail. 2013 Aug 1;1(4):338-344. PubMed PMID: 24159564
  • Fiuzat M, O'Connor CM, Gueyffier F, Mascette AM, Geller NL, Mebazaa A, Voors AA, Adams KF, Piña IL, Neyses L, Muntendam P, Felker GM, Pitt B, Zannad F, Bristow MR. Biomarker-guided therapies in heart failure: a forum for unified strategies. J Card Fail. 2013 Aug;19(8):592-9. PubMed PMID: 23910590
  • Feldman AM, Mann DL, She L, Bristow MR, Maisel AS, McNamara DM, Walsh R, Lee DL, Wos S, Lang I, Wells G, Drazner MH, Schmedtje JF Jr, Pauly DF, Sueta CA, Di Maio M, Kron IL, Velazquez EJ, Lee KL. Prognostic significance of biomarkers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction: results of the biomarker substudy of the Surgical Treatment for Ischemic Heart Failure trials. Circ Heart Fail. 2013 May;6(3):461-72. PubMed PMID: 23584092
  • Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure. Circ Arrhythm Electrophysiol. 2013 Feb;6(1):137-43. PubMed PMID: 23275278
  • Kao DP, Davis G, Aleong R, O'Connor CM, Fiuzat M, Carson PE, Anand IS, Plehn JF, Gottlieb SS, Silver MA, Lindenfeld J, Miller AB, White M, Murphy GA, Sauer W, Bristow MR. Effect of bucindolol on heart failure outcomes and heart rate response in patients with reduced ejection fraction heart failure and atrial fibrillation. Eur J Heart Fail. 2013 Mar;15(3):324-33. PubMed PMID: 23223178
  • Chung MK, Zidar D, Bristow MR, Cameron S, Chan T, Harding CV, Kwon DH, Singth T, Tilton J, Tsai EJ, Tucker NR, Barnard J, Loscalzo J. COVID-19 and Cardiovascular Disease: from Bedside to Bench to Bedside. Circulation, in press. 2021.
  • Knight WE, Cao Y, Ying-Hsi L, Sparagna GC, Bai B, Zhao Y, Chi C, Du Y, Londono P, Reisz JA, Brown BC, Taylor MRG, Abardekar AV, Cleveland JC, McKinsey TA, Jeong MY, Walker LA, Woulfe KC, D’ Alessandro A, Bristow MR, Buttrick PM, Song K. Maturation of human induced pluripotent stem cell-derived cardiomyocytes for modeling hypertrophic cardiomyopathy. doi: https://doi.org/10.1101/2020.01.16.909598 Stem Cell Reports, in press. 2021
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Professional Memberships

  • American Heart Association, Fellow
  • American College of Cardiology, Fellow
  • International Society for Heart Transplant, Member
  • American Federation for Clinical Research, Member
  • American Society of Transplant Physicians, Member
  • Association of American Physicians, Member
  • Heart Failure Society of America, Founding Member, Fellow
  • American Society for Clinical Investigation, Member, Emeritus
  • British Cardiac Society, Invited Member
  • Association of University Cardiologists, Member
  • Heart Rhythm Society, Member
  • European Society of Cardiology, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Heart Failure Program - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

UCHealth Heart & Vascular Center - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1977)
  • General Cardiology, Board Certification (1981)
  • Cardiology, Board Certification (1981)

General Information

Medical Schools:
  • MD, University of Illinois College of Medicine (1970)
Graduate Schools:
  • PhD, University of Illinois, Chicago (1971)
Internships:
  • Stanford University Program (1972)
Residency Programs:
  • Stanford University Program, Internal Medicine (1977)
Fellowships:
  • Stanford Hospital and Clinics Program, General Cardiology (1978)
Languages: English
Department: Medicine-Cardiology
SOM Resources
CU Resources
Contact Us
CU Anschutz
Fitzsimons Building
13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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