Bryan Bergman, PhD

Professional Titles

• Professor

Research Interests

Publications

• Broussard JL, Garfield A, Zarini S, Brozinick JT, Perreault L, Newsom SA, Kahn D, Kerege A, Berry KZ, Bui HH, Bergman BC. Combined diet and exercise training decreases serum lipids associated with insulin resistance. Obesity (Silver Spring). 2024 Dec;32(12):2334-2344. PubMed PMID: 39587896
• Bergman BC, Zemski Berry K, Garfield A, Keller A, Zarini S, Bowen S, McKenna C, Kahn D, Pavelka J, Macias E, Uhlson C, Johnson C, Russ HA, Viesi CH, Seldin M, Liu C, Doliba N, Schoen J, Rothchild K, Hazel K, Naji A. Human peripancreatic adipose tissue paracrine signaling impacts insulin secretion, blood flow, and gene transcription. J Clin Endocrinol Metab. 2024 Nov 1. [Epub ahead of print] PubMed PMID: 39484843
• Zemski Berry KA, Garfield A, Jambal P, Zarini S, Perreault L, Bergman BC. Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle. Diabetologia. 2024 Dec;67(12):2819-2832. PubMed PMID: 39347985
• Gyllenhammer LE, Zaegel V, Duensing AM, Lixandrao ME, Dabelea D, Bergman BC, Boyle KE. Lipidomics of infant mesenchymal stem cells associate with the maternal milieu and child adiposity. JCI Insight. 2024 Sep 3;9(19). PubMed PMID: 39226911
• McKenna CF, Stierwalt HD, Zemski Berry KA, Ehrlicher SE, Robinson MM, Zarini S, Kahn DE, Snell-Bergeon JK, Perreault L, Bergman BC, Newsom SA. Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes. Am J Physiol Endocrinol Metab. 2024 Aug 1;327(2):E183-E193. PubMed PMID: 38895980
• Many GM, Sanford JA, Sagendorf TJ, Hou Z, Nigro P, Whytock KL, Amar D, Caputo T, Gay NR, Gaul DA, Hirshman MF, Jimenez-Morales D, Lindholm ME, Muehlbauer MJ, Vamvini M, Bergman BC, Fernández FM, Goodyear LJ, Hevener AL, Ortlund EA, Sparks LM, Xia A, Adkins JN, Bodine SC, Newgard CB, Schenk S. Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue. Nat Metab. 2024 May;6(5):963-979. PubMed PMID: 38693320
• Jakicic JM, Kohrt WM, Houmard JA, Miller ME, Radom-Aizik S, Rasmussen BB, Ravussin E, Serra M, Stowe CL, Trappe S, Abouassi H, Adkins JN, Alekel DL, Ashley E, Bamman MM, Bergman BC, Bessesen DH, Broskey NT, Buford TW, Burant CF, Chen H, Christle JW, Clish CB, Coen PM, Collier D, Collins KA, Cooper DM, Cortes T, Cutter GR, Dubis G, Fernández FM, Firnhaber J, Forman DE, Gaul DA, Gay N, Gerszten RE, Goodpaster BH, Gritsenko MA, Haddad F, Huffman KM, Ilkayeva O, Jankowski CM, Jin C, Johannsen NM, Johnson J, Kelly L, Kershaw E, Kraus WE, Laughlin M, Lester B, Lindholm ME, Lowe A, Lu CJ, McGowan J, Melanson EL, Montgomery S, Moore SG, Moreau KL, Muehlbauer M, Musi N, Nair VD, Newgard CB, Newman AB, Nicklas B, Nindl BC, Ormond K, Piehowski PD, Qian WJ, Rankinen T, Rejeski WJ, Robbins J, Rogers RJ, Rooney JL, Rushing S, Sanford JA, Schauer IE, Schwartz RS, Sealfon SC, Slentz C, Sloan R, Smith KS, Snyder M, Spahn J, Sparks LM, Stefanovic-Racic M, Tanner CJ, Thalacker-Mercer A, Tracy R, Trappe TA, Volpi E, Walsh MJ, Wheeler MT, Willis L. Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol. J Appl Physiol (1985). 2024 Sep 1;137(3):473-493. PubMed PMID: 38634503
• Perreault L, Bergman BC. Out of stock: A brief clinical reference for rough equivalency of glucagon-like peptide-1 (GLP-1) ± glucose-dependent insulinotropic polypeptide (GIP) receptor agonists for A1c and weight reduction in people with type 2 diabetes. J Diabetes. 2024 Jun;16(6):e13505. PubMed PMID: 37986549
• Erickson ML, Dobias D, Keleher MR, Dabelea D, Bergman BC, Broussard JL, Boyle KE. In Vitro Circadian Clock Gene Expression Assessments in Mesenchymal Stem Cells from Human Infants: A Pilot Study. Nutrients. 2023 Dec 23;16(1). PubMed PMID: 38201882
• Diaz-Vegas A, Madsen S, Cooke KC, Carroll L, Khor JXY, Turner N, Lim XY, Astore MA, Morris JC, Don AS, Garfield A, Zarini S, Zemski Berry KA, Ryan AP, Bergman BC, Brozinick JT, James DE, Burchfield JG. Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle. Elife. 2023 Dec 27;12. PubMed PMID: 38149844
• Perreault L, Bergman BC. Out of stock: A brief clinical reference for rough equivalency of glucagon-like peptide-1 (GLP-1) ± glucose-dependent insulinotropic polypeptide (GIP) receptor agonists for A1c and weight reduction in people with type 2 diabetes. J Diabetes. 2023 Nov 20. [Epub ahead of print] PubMed PMID: 37986549
• Greyslak KT, Hetrick B, Bergman BC, Dean TA, Wesolowski SR, Gannon M, Schenk S, Sullivan EL, Aagaard KM, Kievit P, Chicco AJ, Friedman JE, McCurdy CE. A Maternal Western-Style Diet Impairs Skeletal Muscle Lipid Metabolism in Adolescent Japanese Macaques. Diabetes. 2023 Dec 1;72(12):1766-1780. PubMed PMID: 37725952
• Robinson EL, Bagchi RA, Major JL, Bergman BC, Matsuda JL, McKinsey TA. HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance. J Clin Invest. 2023 Oct 2;133(19). PubMed PMID: 37607030
• Zarini S, Zemski Berry KA, Kahn DE, Garfield A, Perreault L, Kerege A, Bergman BC. Deoxysphingolipids: Atypical Skeletal Muscle Lipids Related to Insulin Resistance in Humans That Decrease Insulin Sensitivity In Vitro. Diabetes. 2023 Jul 1;72(7):884-897. PubMed PMID: 37186949
• Zarini S, Zemski Berry KA, Kahn DE, Garfield A, Perreault L, Kerege A, Bergman BC. Deoxysphingolipids - atypical skeletal muscle lipids related to insulin resistance in humans that decrease insulin sensitivity in vitro. Diabetes. 2023 Apr 24. [Epub ahead of print] PubMed PMID: 37094369
• Nash MJ, Dobrinskikh E, Soderborg TK, Janssen RC, Takahashi DL, Dean TA, Varlamov O, Hennebold JD, Gannon M, Aagaard KM, McCurdy CE, Kievit P, Bergman BC, Jones KL, Pietras EM, Wesolowski SR, Friedman JE. Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring. Cell Rep. 2023 Apr 25;42(4):112393. PubMed PMID: 37058409
• Robinson EL, Bagchi RA, Major JL, Bergman BC, Madsuda JL, McKinsey TA. HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance. bioRxiv. 2023 Mar 30. PubMed PMID: 37034582
• Diaz-Vegas A, Madsen S, Cooke KC, Carroll L, Khor JXY, Turner N, Lim XY, Astore MA, Morris J, Don A, Garfield A, Zarini S, Zemski Berry KA, Ryan A, Bergman BC, Brozinick JT, James DE, Burchfield JG. Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle. bioRxiv. 2023 Sep 19. PubMed PMID: 36945619
• Lutter D, Sachs S, Walter M, Kerege A, Perreault L, Kahn DE, Wolide AD, Kleinert M, Bergman BC, Hofmann SM. Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response. Diabetologia. 2023 May;66(5):873-883. PubMed PMID: 36790478
• Goodpaster BH, Bergman BC, Brennan AM, Sparks LM. Intermuscular adipose tissue in metabolic disease. Nat Rev Endocrinol. 2023 May;19(5):285-298. PubMed PMID: 36564490
• Goodpaster BH, Bergman BC, Brennan AM, Sparks LM. Intermuscular adipose tissue in metabolic disease. Nat Rev Endocrinol. 2022 Dec 23. [Epub ahead of print] PubMed PMID: 36564490
• Kahn D, Macias E, Zarini S, Garfield A, Zemski Berry K, MacLean P, Gerszten RE, Libby A, Solt C, Schoen J, Bergman BC. Exploring Visceral and Subcutaneous Adipose Tissue Secretomes in Human Obesity: Implications for Metabolic Disease. Endocrinology. 2022 Oct 11;163(11). PubMed PMID: 36036084
• Zarini S, Brozinick JT, Zemski Berry KA, Garfield A, Perreault L, Kerege A, Bui HH, Sanders P, Siddall P, Kuo MS, Bergman BC. Serum dihydroceramides correlate with insulin sensitivity in humans and decrease insulin sensitivity in vitro. J Lipid Res. 2022 Oct;63(10):100270. PubMed PMID: 36030929
• Kahn D, Macias E, Zarini S, Garfield A, Zemski Berry K, Gerszten R, Schoen J, Cree-Green M, Bergman BC. Quantifying the inflammatory secretome of human intermuscular adipose tissue. Physiol Rep. 2022 Aug;10(16):e15424. PubMed PMID: 35980018
• Chaves AB, Zheng D, Johnson JA, Bergman BC, Patinkin ZW, Zaegel V, Biagioni EM, Krassovskaia P, Broskey NT, May LE, Dabelea D, Houmard JA, Boyle KE. Infant Mesenchymal Stem Cell Insulin Action Is Associated With Maternal Plasma Free Fatty Acids, Independent of Obesity Status: The Healthy Start Study. Diabetes. 2022 Aug 1;71(8):1649-1659. PubMed PMID: 35621990
• Bodkin SG, Smith AC, Bergman BC, Huo D, Weber KA, Zarini S, Kahn D, Garfield A, Macias E, Harris-Love MO. Utilization of Mid-Thigh Magnetic Resonance Imaging to Predict Lean Body Mass and Knee Extensor Strength in Obese Adults. Front Rehabil Sci. 2022;3. PubMed PMID: 35419566
• Kahn DE, Bergman BC. Keeping It Local in Metabolic Disease: Adipose Tissue Paracrine Signaling and Insulin Resistance. Diabetes. 2022 Apr 1;71(4):599-609. PubMed PMID: 35316835
• Lutter D, Sachs S, Walter M, Kerege A, Perreault L, Kahn DE, Wolide AD, Kleinert M, Bergman BC, Hofmann S. Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response. Diabetologia, Accepted for publication, 2022.
• Kahn D, Perreault L, Macias E, Zarini S, Newsom SA, Strauss A, Kerege A, Harrison K, Snell-Bergeon J, Bergman BC. Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans. Diabetologia. 2021 Jan;64(1):168-180. PubMed PMID: 33128577
• Sparks LM, Goodpaster BH, Bergman BC. The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?. Diabetes. 2021 Nov;70(11):2457-2467. PubMed PMID: 34711670
• Depner CM, Rice JD, Tussey EJ, Eckel RH, Bergman BC, Higgins JA, Melanson EL, Kohrt WM, Wright KP Jr, Swanson CM. Bone turnover marker responses to sleep restriction and weekend recovery sleep. Bone. 2021 Nov;152:116096. PubMed PMID: 34216838
• Depner CM, Melanson EL, Eckel RH, Higgins JA, Bergman BC, Perreault L, Knauer OA, Birks BR, Wright KP. Effects of ad libitum food intake, insufficient sleep and weekend recovery sleep on energy balance. Sleep. 2021 Nov 12;44(11). PubMed PMID: 34059916
• Pyle L, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Nadeau KJ, Cree-Green M. Fasting plasma metabolomic profiles are altered by three days of standardized diet and restricted physical activity. Metabol Open. 2021 Mar;9:100085. PubMed PMID: 33665598
• Broussard JL, Perreault L, Macias E, Newsom SA, Harrison K, Bui HH, Milligan P, Roth KD, Nemkov T, D'Alessandro A, Brozinick JT, Bergman BC. Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution. Obesity (Silver Spring). 2021 Mar;29(3):550-561. PubMed PMID: 33624435
• Fridman V, Zarini S, Sillau S, Harrison K, Bergman BC, Feldman EL, Reusch JEB, Callaghan BC. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021 Apr;35(4):107852. PubMed PMID: 33485750
• Kahn D, Perreault L, Macias E, Zarini S, Newsom SA, Strauss A, Kerege A, Harrison K, Snell-Bergeon J, Bergman BC. Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans. Diabetologia. 2021 Jan;64(1):168-180. PubMed PMID: 33128577
• Correa-de-Araujo R, Addison O, Miljkovic I, Goodpaster BH, Bergman BC, Clark RV, Elena JW, Esser KA, Ferrucci L, Harris-Love MO, Kritchevsky SB, Lorbergs A, Shepherd JA, Shulman GI, Rosen CJ. Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging. Front Physiol. 2020;11:963. PubMed PMID: 32903666
• Bergman BC, Goodpaster BH. Exercise and Muscle Lipid Content, Composition, and Localization: Influence on Muscle Insulin Sensitivity. Diabetes. 2020 May;69(5):848-858. PubMed PMID: 32312901
• Guth A, Monk E, Agarwal R, Bergman BC, Zemski-Berry KA, Minic A, Jordan K, Schlaepfer IR. Targeting Fat Oxidation in Mouse Prostate Cancer Decreases Tumor Growth and Stimulates Anti-Cancer Immunity. Int J Mol Sci. 2020 Dec 18;21(24). PubMed PMID: 33352903
• Broussard JL, Perreault L, Macias E, Newsom SA, Harrison K, Bui HH, Milligan P, Roth KD, Nemkov T, D’Alessandro A, Brozinick JT, Bergman BC. Sex differences in insulin sensitivity are related to muscle tissue acylcarnitine but not subcellular lipid distribution. Obesity, Accepted for publication, 2020
• MoTrPAC Consortium. Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Cell, in press 2020
• Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance. Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E186-E195. PubMed PMID: 30562061
• Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism. Obesity (Silver Spring). 2019 Dec;27(12):2046-2054. PubMed PMID: 31659873
• Harrison KA, Bergman BC. HPLC-MS/MS Methods for Diacylglycerol and Sphingolipid Molecular Species in Skeletal Muscle. Methods Mol Biol. 2019;1978:137-152. PubMed PMID: 31119661
• Cree-Green M, Bergman BC, Cengiz E, Fox LA, Hannon TS, Miller K, Nathan B, Pyle L, Kahn D, Tansey M, Tichy E, Tsalikian E, Libman I, Nadeau KJ. Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3265-3278. PubMed PMID: 30938764
• Cree-Green M, Bergman BC, Cengiz E, Fox LA, Hannon TS, Miller K, Nathan B, Pyle L, Kahn D, Tansey M, Tichy E, Tsalikian E, Libman I, Nadeau KJ. Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3265-3278. PubMed PMID: 30938764
• Depner CM, Melanson EL, Eckel RH, Snell-Bergeon JK, Perreault L, Bergman BC, Higgins JA, Guerin MK, Stothard ER, Morton SJ, Wright KP Jr. Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep. Curr Biol. 2019 Mar 18;29(6):957-967.e4. PubMed PMID: 30827911
• Cree-Green M, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Pyle L, Nadeau KJ. Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E707-E718. PubMed PMID: 30753112
• Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, Newsom SA, Strauss A, Kerege A, Schoen JA, Bessesen DH, Schwarzmayr T, Graf E, Lutter D, Krumsiek J, Hofmann SM, Bergman BC. Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E866-E879. PubMed PMID: 30620635
• Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, Newsom SA, Strauss A, Kerege A, Schoen JA, Bessesen DH, Schwarzmayr T, Graf E, Lutter D, Krumsiek J, Hofmann S, Bergman BC. Intermuscular adipose tissue (IMAT) directly modulates skeletal muscle insulin sensitivity in humans. Am J Physiol Endocrinol Metab. 2019 Jan 8. [Epub ahead of print] PubMed PMID: 30620635
• Stierwalt HD, Ehrlicher SE, Bergman BC, Robinson MM, Newsom SA. Insulin-stimulated Rac1-GTP binding is not impaired by palmitate treatment in L6 myotubes. Physiol Rep. 2018 Dec;6(24):e13956. PubMed PMID: 30592185
• Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth with Type 2 Diabetes Have Hepatic, Peripheral and Adipose Insulin Resistance. Am J Physiol Endocrinol Metab. 2018 Dec 18. [Epub ahead of print] PubMed PMID: 30562061
• Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 Dec;18:25-41. PubMed PMID: 30337225
• Cree-Green M, Stuppy JJ, Thurston J, Bergman BC, Coe GV, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3647-3657. PubMed PMID: 30020457
• Cree-Green M, Xie D, Rahat H, Garcia-Reyes Y, Bergman BC, Scherzinger A, Diniz Behn C, Chan CL, Kelsey MM, Pyle L, Nadeau KJ. Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls. J Endocr Soc. 2018 Jun 1;2(6):547-562. PubMed PMID: 29942919
• Millstein RJ, Pyle LL, Bergman BC, Eckel RH, Maahs DM, Rewers MJ, Schauer IE, Snell-Bergeon JK. Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort. J Diabetes Complications. 2018 Apr;32(4):418-423. PubMed PMID: 29449137
• Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC. Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight. 2018 Feb 8;3(3). [Epub ahead of print] PubMed PMID: 29415895
• Bergman BC, Perreault L, Strauss A, Bacon S, Kerege A, Harrison K, Brozinick JT, Hunerdosse DM, Playdon MC, Holmes W, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Eckel RH. Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans. Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E152-E164. PubMed PMID: 28978544
• Harrison, KA, Bergman, BC. “HPLC-MS/MS Methods for Diacylglycerol and Sphingolipid Molecular Species in Skeletal Muscle”, in High Throughput Metabolomics and Protocols, Angelo D’Alessandro (Ed.), Methods in Molecular Biology, Springer Nature, in press 2019.
• Simens JL, Cree-Green M, Bergman BC, Nadeau KJ, Diniz-Behn C. Structural Identifiability Analysis of a Labeled Oral Minimal Model for Quantifying Hepatic Insulin Resistance. Advances in the Mathematical Sciences, accepted 2018.
• Stierwalt HD, Ehrlicher SE, Bergman BC, Robinson MM, Newsom SA. Insulin-stimulated Rac1-GTP binding is not impaired by palmitate treatment in L6 myotubes. Physiol Rep. 2018 Dec;6(24):e13956. PubMed PMID: 30592185
• Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 Dec;18:25-41. PubMed PMID: 30337225
• Cree-Green M, Stuppy JJ, Thurston J, Bergman BC, Coe GV, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3647-3657. PubMed PMID: 30020457
• Cree-Green M, Xie D, Rahat H, Garcia-Reyes Y, Bergman BC, Scherzinger A, Diniz Behn C, Chan CL, Kelsey MM, Pyle L, Nadeau KJ. Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls. J Endocr Soc. 2018 Jun 1;2(6):547-562. PubMed PMID: 29942919
• Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC. Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle. JCI Insight. 2018 Feb 8;3(3). PubMed PMID: 29415895
• Millstein RJ, Pyle LL, Bergman BC, Eckel RH, Maahs DM, Rewers MJ, Schauer IE, Snell-Bergeon JK. Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort. J Diabetes Complications. 2018 Apr;32(4):418-423. PubMed PMID: 29449137
• Bergman BC, Perreault L, Strauss A, Bacon S, Kerege A, Harrison K, Brozinick JT, Hunerdosse DM, Playdon MC, Holmes W, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Eckel RH. Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans. Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E152-E164. PubMed PMID: 28978544
• Bergman BC, Perreault L, Strauss A, Bacon SD, Kerege AA, Harrison K, Brozinick JT, Hunerdosse DM, Playdon MC, Holmes W, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Eckel RH. Intramuscular triglyceride synthesis - importance in partitioning muscle lipids in humans. Am J Physiol Endocrinol Metab. 2017 Oct 3;:ajpendo.00142.2017. [Epub ahead of print] PubMed PMID: 28978544
• Mukhopadhyay S, Schlaepfer IR, Bergman BC, Panda PK, Praharaj PP, Naik PP, Agarwal R, Bhutia SK. ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway. Free Radic Biol Med. 2017 Mar;104:199-213. PubMed PMID: 28069524
• Perreault L, Newsom S, Strauss A, Kerege A, Kahn D, Harrison K, Snell-Bergeon J, Nemkov T, D’Alessandro A, Jackman M, MacLean P, Bergman BC. Intracellular Localization of Diacylglycerols and Sphingolipids Influence Insulin Sensitivity and Mitochondrial Function in Human Skeletal Muscle. JCI Insight, accepted 2017
• Mukhopadhyay S, Schlaepfer IR, Bergman BC, Panda PK, Praharaj PP, Naik PP, Agarwal R, Bhutia SK. ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway. Free Radic Biol Med. 2017 Jan 6;104:199-213. [Epub ahead of print] PubMed PMID: 28069524
• Cree-Green M, Bergman BC, Coe GV, Newnes L, Baumgartner AD, Bacon S, Sherzinger A, Pyle L, Nadeau KJ. Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance. Obesity (Silver Spring). 2016 Nov;24(11):2399-2406. PubMed PMID: 27804265
• McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016 Oct 6;1(16):e86612. PubMed PMID: 27734025
• Newsom SA, Brozinick JT, Kiseljak-Vassiliades K, Strauss AN, Bacon SD, Kerege AA, Bui HH, Sanders P, Siddall P, Wei T, Thomas M, Kuo MS, Nemkov T, D'Alessandro A, Hansen KC, Perreault L, Bergman BC. Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans. J Appl Physiol (1985). 2016 Jun 1;120(11):1355-63. PubMed PMID: 27032901
• Guess N, Perreault L, Kerege A, Strauss A, Bergman BC. Dietary Fatty Acids Differentially Associate with Fasting Versus 2-Hour Glucose Homeostasis: Implications for The Management of Subtypes of Prediabetes. PLoS One. 2016 Mar 21;11(3):e0150148. PubMed PMID: 26999667
• Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Perreault L. Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans. Diabetologia. 2016 Apr;59(4):785-98. PubMed PMID: 26739815
• Pyle L, Bergman BC, Nadeau KJ, Cree-Green M. Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined. Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E323-31. PubMed PMID: 26714848
• Duca LM, Maahs DM, Schauer IE, Bergman BC, Nadeau KJ, Bjornstad P, Rewers M, Snell-Bergeon JK. Development and Validation of a Method to Estimate Insulin Sensitivity in Patients With and Without Type 1 Diabetes. J Clin Endocrinol Metab. 2016 Feb;101(2):686-95. PubMed PMID: 26672636
• Perreault L, Starling AP, Glueck D, Brozinick JT, Sanders P, Siddall P, Kuo MS, Dabelea D, Bergman BC. Biomarkers of Ectopic Fat Deposition: The Next Frontier in Serum Lipidomics. J Clin Endocrinol Metab. 2016 Jan;101(1):176-82. PubMed PMID: 26574956
• Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Perreault L. Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans. Diabetologia. 2016 Jan 6. [Epub ahead of print] PubMed PMID: 26739815
• Cree-Green M, Bergman BC, Coe GV, Newnes L, Baumgartner AD, Bacon S, Sherzinger A, Pyle L, Nadeau KJ. Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance. Obesity (Silver Spring). 2016 Nov;24(11):2399-2406. PubMed PMID: 27804265
• Perreault L, Starling AP, Glueck D, Brozinick JT, Sanders P, Siddall P, Kuo MS, Dabelea D, Bergman BC. Biomarkers of Ectopic Fat Deposition: The Next Frontier in Serum Lipidomics. J Clin Endocrinol Metab. 2016 Jan;101(1):176-82. PubMed PMID: 26574956
• Yu T, Taussig MD, DiPatrizio NV, Astarita G, Piomelli D, Bergman BC, Dell'Acqua ML, Eckel RH, Wang H. Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. PLoS One. 2015;10(8):e0135113. PubMed PMID: 26263173
• Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH, Sanders P, Siddall P, Kuo MS, Perreault L. Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans. Am J Physiol Endocrinol Metab. 2015 Aug 15;309(4):E398-408. PubMed PMID: 26126684
• Combs TP, Snell-Bergeon JK, Maahs DM, Bergman BC, Lamarche M, Iberkleid L, AbdelBaky O, Tisch R, Scherer PE, Marliss EB. Adiponectin-SOGA Dissociation in Type 1 Diabetes. J Clin Endocrinol Metab. 2015 Aug;100(8):E1065-73. PubMed PMID: 26052615
• Schlaepfer IS, Nambiar D, Ramteke A, Kumar R, Dhar D, Agarwal C, Bergman BC, Graner M, Maroni P, Singh RP, Agarwal R, Deep R. Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation. Oncotarget, Sep 8;6(26):22836-56, 2015.
• Cree-Green M, Newcomer BR, Brown MS, West AD, Drew B, Regensteiner JG, Bergman BC, Pyle L, Reusch JEB, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes, 2015 Feb;64(2):383-92. PMID: 25157095.
• Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed Skeletal Muscle Mitochondrial ADP Recovery in Youth With Type 1 Diabetes Relates to Muscle Insulin Resistance. Diabetes. 2015 Feb;64(2):383-92. PubMed PMID: 25157095
• Pyle L, Bergman BC, Nadeau KJ, Cree-Green M. Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot readily be determined. Am J Physiol Endocrinol Metab. 2015 Dec 29;:ajpendo.00368.2015. [Epub ahead of print] PubMed PMID: 26714848
• Duca LM, Maahs DM, Schauer IE, Bergman BC, Nadeau KJ, Bjornstad P, Rewers M, Snell-Bergeon JK. Development and validation of a method to estimate insulin sensitivity in patients with and without type 1 diabetes. J Clin Endocrinol Metab. 2015 Dec 16;:jc20153272. [Epub ahead of print] PubMed PMID: 26672636
• Perreault L, Færch K, Kerege AA, Bacon SD, Bergman BC. Hepatic glucose sensing is impaired, but can be normalized, in people with impaired fasting glucose. J Clin Endocrinol Metab. 2014 Jul;99(7):E1154-62. PubMed PMID: 24731008
• Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE. Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 2014 Aug;63(8):2702-13. PubMed PMID: 24705404
• Perreault L, McCurdy C, Kerege AA, Houck J, Færch K, Bergman BC. Bisphenol A impairs hepatic glucose sensing in C57BL/6 male mice. PLoS One. 2013;8(7):e69991. PubMed PMID: 23922885
• Huang JV, Lu L, Ye S, Bergman BC, Sparagna GC, Sarraf M, Reusch JE, Greyson CR, Schwartz GG. Impaired contractile recovery after low-flow myocardial ischemia in a porcine model of metabolic syndrome. Am J Physiol Heart Circ Physiol. 2013 Mar 15;304(6):H861-73. PubMed PMID: 23335793
• Bergman BC, Howard D, Schauer IE, Maahs DM, Snell-Bergeon JK, Clement TW, Eckel RH, Perreault L, Rewers M. The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in type 1 diabetes. J Clin Endocrinol Metab. 2013 Jan;98(1):E40-50. PubMed PMID: 23150678
• Perreault, L, Færch, JK, Kerege, AA, Bacon, SD, Bergman, BC. Hepatic Glucose Sensing is Impaired, but can be Normalized with Fructose, in People with Impaired Fasting Glucose, Journal of Clinical Endocrinology and Metabolism, accepted for publication, 2013.
• Huang, J, Lu, L, Xu, Y, Sarraf, M, Bergman, BC, Sparagna, G, Reusch, J, Greyson, C, Schwartz, GG. Mechanisms of Impaired Contractile Recovery after Low-Flow Myocardial Ischemia in a Porcine Model of Metabolic Syndrome. American Journal of Physiology, in press.
• Bergman, BC, Hunerdosse, DM, Kerege, A, Playdon, MC, Perreault, L. Localization and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans. Diabetologia, Jan 15, 2012. PMID: 22252470.
• Pereira, R, Snell-Bergeon, JK, Erickson, C, Schauer, I, Bergman, BC, Rewers, M, Maahs, DM. Adiponectin dysregulation and insulin resistance in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, Jan 25, 2012. PMID: 22278421.
• Bergman, BC, Howard, D, Schauer,, IE, Maahs, DM, Snell-Bergeon, JK, Eckel, RH, Perreault, L, Rewers, M. Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes in humans. Journal of Clinical Endocrinology and Metabolism, accepted for publication.
• Færch K, Bergman BC, Perreault, L. Does insulin resistance drive the association between hyperglycemia and cardiovascular risk? PLoS ONE, 2012;7(6):e39260. Epub 2012 Jun 15. PMID: 22720085
• Schlaepfer, IR, Hitz, CA Gijon, MA, Bergman, BC, Eckel, RH and Jacobsen, BM. Progestin modulates the lipid profile and sensitivity to docetaxel of breast cancer cells. Mol Cell Endocrinol. 2012 Nov 5;363(1-2):111-21. PMID: 22922095
• Bergman, BC, Howard, D, Schauer,, IE, Maahs, DM, Snell-Bergeon, JK, Clement, T, Eckel, RH, Perreault, L, Rewers, M. The importance of palmitoleic acid to adipocyte insulin resistance and whole body insulin sensitivity in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 98: E40-50, 2013. Epub Nov 2012. PMID: 23150678
• Perreault, L, Bergman BC, Hunerdosse DM, Howard, DJ, Eckel RH. Fenofibrate adminstration does not affect intramuscular triglyceride concentration or insulin sensitivity in humans. Metabolism, 2011 Feb 7. PMID: 21306746
• Lee, J., Xu, Y., Lu, L., Bergman, BC., Leitner, JW., Greyson, C., Draznin, B., Schwartz, GG. Multiple Abnormalities of Myocardial Insulin Signaling in a Porcine Model of Diet-induced Obesity. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H310-9. Epub 2009 Nov 6.
• Perreault, L, Bergman, BC, Hunerdosse, D, Eckel, Robert. Inflexibility In Intramuscular Triglyceride Fractional Synthesis Distinguishes Pre-Diabetes From Obesity In Humans, Obesity (Silver Spring). 2009 Dec 24. [Epub ahead of print].
• Perreault, L, Bergman, BC, Hunerdosse, D, Eckel, Robert. Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in the progression to diabetes. Obesity (Silver Spring). 2010 Aug; 18(8):1524-31. PMID: 20379150
• Bergman, BC, Perreault, L, Playdon, MC, Samek, A, Eckel, RH. Increased intramuscular lipid synthesis and decreased diacylglycerol saturation in endurance trained athletes, Journal of Applied Physiology, 2010 May;108(5):1134-41 PMID: 20299618
• Maahs, DM, Wang H, Kinney, G, Snell-Bergeon J, East, A, Bergman BC, Schauer IE, A, Rewers, M, R.H. Eckel. Lipoprotein Subfraction Cholesterol Distribution is Pro- Atherogenic in Women with Type 1 Diabetes and Insulin Resistance. Diabetes. 2010 Jul;59(7):1771-9. Epub 2010 Apr 14. PMID: 20393149
• Perreault, L, Dalla Man, C, Hunerdosse, DM, Cobelli, C, Bergman, BC. Incretin action maintains insulin secretion, but not hepatic insulin action, in people with impaired fasting glucose. Diab Res Clin Pract. 2010 Oct; 90(1); 87-94. PMID: 20708814
• Snell-Bergeon, JK, Roman, R, Rodbard, D, Garg, S, Maahs, DM, Schauer, IE, Bergman, BC, Kinney, GL, Rewers, M. Glycaemic Variability is Associated with Coronary Artery Calcium in Men with Type 1 Diabetes: The Coronary Artery Calcification in Type 1 Diabetes Study. Diabet Med. 2010 Dec;27(12):1436-42. PMID: 21059097
• Maahs, DM, Nadeau, K, Snell-Bergeon J, Schauer IE, Bergman BC, , West, N, Rewers, M, Daniels, S, Ogden, L, Hamman, R, Dabelea, D. Association of Insulin Sensitivity to Lipids Across the Lifespan in People with Type 1 Diabetes. Diabet Med. 2011 Feb;28(2):148-55. PMID: 21219421
• Schauer, IE, Snell-Bergeon, JK, Bergman, BC, Maahs, DM, Kretowski, A, Eckel, RH, and Rewers, M. Insulin resistance, including defective insulin-mediated fatty acid suppression, is associated with coronary artery calcification in type 1 diabetic subjects: The CACTI study, Diabetes. 2011 Jan;60(1):306-14. Epub 2010 Oct 26. PMID: 20978091
• Perreault L, Bergman BC, Hunerdosse DM, Howard, DJ, Eckel RH. Fenofibrate adminstration does not affect intramuscular triglyceride concentration or insulin sensitivity in humans. Metabolism, 2011 Feb 7. PMID: 21306746
• Bergman, BC, Tsvetkova, T, Lowes, B, and Wolfel, EE. Myocardial FFA Metabolism During Rest and Atrial Pacing in Humans. American Journal of Physiology 296: E358-E366, 2009. First published December 9, 2008; doi:10.1152/ajpendo.90747.2008.
• Bergman, BC, Tsvetkova, T, Lowes, B, and Wolfel, EE. Myocardial Glucose and Lactate Metabolism During Rest and Atrial Pacing in Humans. Journal of Physiology, accepted for publication, 2009.
• Bergman, BC, Perreault, L, Hunerdosse, MD, Playdon, MC, Samek, A, Eckel, RH. Intramuscular lipid metabolism in the insulin resistance of smoking. Diabetes, October 58:2220-2227, 2009.
• Lee, JK, Xu Y, Lu L, Leitner W, Greyson C, Bergman B, Draznin B, Schwartz GG. A novel porcine model of diet-induced obesity causes deranged myocardial insulin signaling. J of Invest Med 55(1): 174, 2008.
• Perreault, L, Bergman, BC, Playdon, MC, Dall Man, C, Cobelli, C, Eckel, RH. Impaired Fasting Glucose with or without Impaired Glucose Tolerance: Progressive or Parallel States of Pre-diabetes? American Journal of Physiology, Aug;295(2):E428-35, 2008.
• Bergman, BC, Cornier, MA, Horton, TJ, and Bessesen, DH, Eckel, RH. Skeletal Muscle Munc18c and Syntaxin 4 in Human Obesity. Nutrition and Metabolism, 5:21 (24Jul2008), 2008.
• Sparagna G, Xu Y, Lu L, Chicco A, Bergman B, Schwartz GG. Pathologic remodeling of myocardial cardiolipin in a porcine model of diet-induced obesity and insulin resistance. Circulation 116(16): Suppl. S, p90, 2007.
• Bergman, BC, Cornier, MA, Horton, TJ, and Bessesen, DH. Effects Of Fasting On Insulin Action And Glucose Kinetics In Lean And Obese Men And Women. Am J Physiol Endocrinol Metab (August 7, 2007). doi:10.1152/ajpendo.00613.2006.
• Bergman, BC, Jensen, DR, Pulawa, LK, Ferreira, L, and Eckel, RH. Fasting decreases free fatty acid turnover in mice over-expressin skeletal muscle lipoprotein lipase. Metabolism, 55:1481-1487, 2006
• Cornier, MA, Bergman, BC, Bessesen, DH. The effects of short-term overfeeding on insulin action in lean and reduced-obese individuals. Metabolism, 55:1207-1214, 2006.
• BC. Bergman, T Tsvetkova, B Lowes, and EE. Wolfel. Myocardial Glucose and Lactate Metabolism During Rest and Atrial Pacing in Humans. NPAM American Heart Association Conference, 2008.
• B.C.Bergman, L.Perreault, M.Koehler, A.Samek, R.H.Eckel. Does intramuscular triglyceride concentration, saturation, or turnover explain insulin resistance in smokers? Diabetes, Supplement, In press 2008.

Practice Locations

Specialty Information

• Psychology