Robert Eckel, MD

Professional Titles

• Professor
• UCDenver Vice Chancellor for Research, Interim

Recognitions

• Best (Top) Doctors in America Recognition, Best (Top) Doctors in America (2017)
  From peers - since 1994
• The W. Virgil Brown Distinguished Achievement Award and Lectureship, National Lipid Association (2017)
  Contributions to research and policy on lipids and lipoproteins.
• President’s Council on Fitness, Sports & Nutrition Science Board, President’s Council on Fitness, Sports & Nutrition (2016)
  Advise the President on Fitness, Sports & Nutrition via the Secretary of HHS.
• Distinguished Alumni Award, University of Cincinnati College of Medicine (2013)
  Accomplishments in medicine since graduation
• Robert H. Herman Award, American Society for Nutrition (2011)
  Nutrition science
• Gold Heart Award, American Heart Association (2010)
  Service to the AHA
• Stare-Hegsted Award in Nutrition Science, Harvard School of Public Health (2007)
  Research and pubic awareness of the importance of heart healthy nutrition.
• TOPS (Take Off Pounds Sensibly) Award for Research in Obesity, Obesity Society (2005)
  Research in obesity
• Charles A. Boettcher Endowed Chair in Atherosclerosis, Boettcher Foundation (2000)
  Relates to how my basic science relates to my role as a clinician.

Research Interests

Publications

• Millstein RJ, Pyle LL, Bergman BC, Eckel RH, Maahs DM, Rewers MJ, Schauer IE, Snell-Bergeon JK. Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort. J Diabetes Complications. 2018 Jan 10. [Epub ahead of print] PubMed PMID: 29449137
• Saxon DR, Rasouli N, Eckel RH. Pharmacological Prevention of Cardiovascular Outcomes in Diabetes Mellitus: Established and Emerging Agents. Drugs. 2018 Feb;78(2):203-214. PubMed PMID: 29305768
• Gadek KE, Wang H, Hall MN, Sungello M, Libby A, MacLaskey D, Eckel RH, Olwin BB. Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency. PLoS One. 2018;13(1):e0190963. PubMed PMID: 29304082
• Bergman BC, Perreault L, Strauss A, Bacon S, Kerege A, Harrison K, Brozinick JT, Hunerdosse DM, Playdon MC, Holmes W, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Eckel RH. Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans. Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E152-E164. PubMed PMID: 28978544
• Bergman BC, Perreault L, Strauss A, Bacon S, Kerege A, Harrison K, Brozinick JT, Hunerdosse DM, Playdon MC, Holmes W, Bui HH, Sanders P, Siddall P, Wei T, Thomas MK, Kuo MS, Eckel RH. Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans. Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E152-E164. PubMed PMID: 28978544
• Gadek KE, Wang H, Hall MN, Sungello M, Libby A, MacLaskey D, Eckel RH, Olwin BB. Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency. PLoS One. 2018;13(1):e0190963. PubMed PMID: 29304082
• Saxon DR, Rasouli N, Eckel RH. Pharmacological Prevention of Cardiovascular Outcomes in Diabetes Mellitus: Established and Emerging Agents. Drugs. 2018 Feb;78(2):203-214. PubMed PMID: 29305768
• Millstein RJ, Pyle LL, Bergman BC, Eckel RH, Maahs DM, Rewers MJ, Schauer IE, Snell-Bergeon JK. Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort. J Diabetes Complications. 2018 Apr;32(4):418-423. PubMed PMID: 29449137
• Lim S, Eckel RH, Koh KK. Clinical implications of current cardiovascular outcome trials with sodium glucose cotransporter-2 (SGLT2) inhibitors. Atherosclerosis. 2018 May;272:33-40. PubMed PMID: 29547706
• Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB, Eckel RH. Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018;11:57. PubMed PMID: 29599706
• Ibrahim M, Tuomilehto J, Aschner P, Beseler L, Cahn A, Eckel RH, Fischl AH, Guthrie G, Hill JO, Kumwenda M, Leslie RD, Olson DE, Pozzilli P, Weber SL, Umpierrez GE. Global status of diabetes prevention and prospects for action: A consensus statement. Diabetes Metab Res Rev. 2018 Sep;34(6):e3021. PubMed PMID: 29757486
• Palmisano BT, Zhu L, Eckel RH, Stafford JM. Sex differences in lipid and lipoprotein metabolism. Mol Metab. 2018 Sep;15:45-55. PubMed PMID: 29858147
• Bjornstad P, Eckel RH. Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review. Curr Diab Rep. 2018 Oct 17;18(12):127. PubMed PMID: 30328521
• Kabakambira JD, Baker RL Jr, Briker SM, Courville AB, Mabundo LS, DuBose CW, Chung ST, Eckel RH, Sumner AE. Do current guidelines for waist circumference apply to black Africans? Prediction of insulin resistance by waist circumference among Africans living in America. BMJ Glob Health. 2018;3(5):e001057. PubMed PMID: 30364383
• Thirunavukkarasu M, Selvaraju V, Joshi M, Coca-Soliz V, Tapias L, Saad I, Fournier C, Husain A, Campbell J, Yee SP, Sanchez JA, Palesty JA, McFadden DW, Maulik N. Disruption of VEGF Mediated Flk-1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino-1. J Am Heart Assoc. 2018 Sep 18;7(18):e007601. PubMed PMID: 30371196
• Basu D, Huggins LA, Scerbo D, Obunike J, Mullick AE, Rothenberg PL, Di Prospero NA, Eckel RH, Goldberg IJ. Mechanism of Increased LDL (Low-Density Lipoprotein) and Decreased Triglycerides With SGLT2 (Sodium-Glucose Cotransporter 2) Inhibition. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2207-2216. PubMed PMID: 30354257
• Eckel RH. IN: Endocrine and Metabolic Medical Emergencies. Emergency Management Related to Obesity and Clinical Lipidology Ed Martin G. pp 217-222, 2018
• Eckel RH. The Metabolic Syndrome. IN: Harrison’s Principles of Internal Medicine. Ed. Jameson JL, Fauci AS, Kasper DL, Longo DL, , Loscalzo J: McGraw Hill Medical, 17th edition, pp. 1509-1514, 2018.
• Rubino F, Nathan DM, Eckel RH, Schauer PR, Alberti KG, Zimmet PZ, Del Prato S, Ji L, Sadikot SM, Herman WH, Amiel SA, Kaplan LM, Taroncher-Oldenburg G, Cummings DE. Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: a Joint Statement by International Diabetes Organizations. Obes Surg. 2017 Jan;27(1):2-21. PubMed PMID: 27957699
• Gao Y, Vidal-Itriago A, Kalsbeek MJ, Layritz C, García-Cáceres C, Tom RZ, Eichmann TO, Vaz FM, Houtkooper RH, van der Wel N, Verhoeven AJ, Yan J, Kalsbeek A, Eckel RH, Hofmann SM, Yi CX. Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity. Cell Rep. 2017 Sep 26;20(13):3034-3042. PubMed PMID: 28954222
• Gao Y, Layritz C, Legutko B, Eichmann TO, Laperrousaz E, Moullé VS, Cruciani-Guglielmacci C, Magnan C, Luquet S, Woods SC, Eckel RH, Yi CX, Garcia-Caceres C, Tschöp MH. Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity. Diabetes. 2017 Oct;66(10):2555-2563. PubMed PMID: 28710138
• Seggelke SA, Lindsay MC, Hazlett I, Sanagorski R, Eckel RH, Low Wang CC. Cardiovascular Safety of Antidiabetic Drugs in the Hospital Setting. Curr Diab Rep. 2017 Aug;17(8):64. PubMed PMID: 28699089
• Alman AC, Smith SR, Eckel RH, Hokanson JE, Burkhardt BR, Sudini PR, Wu Y, Schauer IE, Pereira RI, Snell-Bergeon JK. The ratio of pericardial to subcutaneous adipose tissues is associated with insulin resistance. Obesity (Silver Spring). 2017 Jul;25(7):1284-1291. PubMed PMID: 28558132
• Laperrousaz E, Moullé VS, Denis RG, Kassis N, Berland C, Colsch B, Fioramonti X, Philippe E, Lacombe A, Vanacker C, Butin N, Bruce KD, Wang H, Wang Y, Gao Y, Garcia-Caceres C, Prévot V, Tschöp MH, Eckel RH, Le Stunff H, Luquet S, Magnan C, Cruciani-Guglielmacci C. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice. Diabetologia. 2017 Jul;60(7):1314-1324. PubMed PMID: 28456865
• Bruce KD, Zsombok A, Eckel RH. Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism. Front Endocrinol (Lausanne). 2017;8:60. PubMed PMID: 28421037
• Yu T, Sungelo MJ, Goldberg IJ, Wang H, Eckel RH. Streptozotocin-Treated High Fat Fed Mice: A New Type 2 Diabetes Model Used to Study Canagliflozin-Induced Alterations in Lipids and Lipoproteins. Horm Metab Res. 2017 May;49(5):400-406. PubMed PMID: 28395380
• Crawford ED, Schally AV, Pinthus JH, Block NL, Rick FG, Garnick MB, Eckel RH, Keane TE, Shore ND, Dahdal DN, Beveridge TJR, Marshall DC. The potential role of follicle-stimulating hormone in the cardiovascular, metabolic, skeletal, and cognitive effects associated with androgen deprivation therapy. Urol Oncol. 2017 May;35(5):183-191. PubMed PMID: 28325650
• Taha DA, Zgair A, Lee JB, de Moor CH, Barrett DA, Bruce KD, Sungelo M, Eckel RH, Gershkovich P. Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity. Eur J Pharm Sci. 2017 Mar 30;100:163-175. PubMed PMID: 28104473
• Patel SS, Truong U, King M, Ferland A, Moreau KL, Dorosz J, Hokanson JE, Wang H, Kinney GL, Maahs DM, Eckel RH, Nadeau KJ, Cree-Green M. Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers. Vasc Med. 2017 Apr;22(2):85-95. PubMed PMID: 28095749
• Skyler JS, Bakris GL, Bonifacio E, Darsow T, Eckel RH, Groop L, Groop PH, Handelsman Y, Insel RA, Mathieu C, McElvaine AT, Palmer JP, Pugliese A, Schatz DA, Sosenko JM, Wilding JP, Ratner RE. Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis. Diabetes. 2017 Feb;66(2):241-255. PubMed PMID: 27980006
• Rubino F, Nathan DM, Eckel RH, Schauer PR, Alberti KG, Zimmet PZ, Del Prato S, Ji L, Sadikot SM, Herman WH, Amiel SA, Kaplan LM, Taroncher-Oldenburg G, Cummings DE. Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: a Joint Statement by International Diabetes Organizations. Obes Surg. 2017 Jan;27(1):2-21. PubMed PMID: 27957699
• Taha DA, Zgair A, Lee JB, de Moor CH, Barrett DA, Bruce KD, Sungelo M, Eckel RH, Gershkovich P. Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity. Eur J Pharm Sci. 2017 Jan 16;100:163-175. [Epub ahead of print] PubMed PMID: 28104473
• Patel SS, Truong U, King M, Ferland A, Moreau KL, Dorosz J, Hokanson JE, Wang H, Kinney GL, Maahs DM, Eckel RH, Nadeau KJ, Cree-Green M. Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers. Vasc Med. 2017 Jan 1;:1358863X16682107. [Epub ahead of print] PubMed PMID: 28095749
• Skyler JS, Bakris GL, Bonifacio E, Darsow T, Eckel RH, Groop L, Groop PH, Handelsman Y, Insel RA, Mathieu C, McElvaine AT, Palmer JP, Pugliese A, Schatz DA, Sosenko JM, Wilding JP, Ratner RE. Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis. Diabetes. 2017 Feb;66(2):241-255. PubMed PMID: 27980006
• Ray KK, Ginsberg HN, Davidson MH, Pordy R, Bessac L, Minini P, Eckel RH, Cannon CP. Reductions in Atherogenic Lipids and Major Cardiovascular Events: A Pooled Analysis of 10 ODYSSEY Trials Comparing Alirocumab With Control. Circulation. 2016 Dec 13;134(24):1931-1943. PubMed PMID: 27777279
• Saxon DR, Eckel RH. Statin Intolerance: A Literature Review and Management Strategies. Prog Cardiovasc Dis. 2016 Sep - Oct;59(2):153-164. PubMed PMID: 27497504
• Rubino F, Nathan DM, Eckel RH, Schauer PR, Alberti KG, Zimmet PZ, Del Prato S, Ji L, Sadikot SM, Herman WH, Amiel SA, Kaplan LM, Taroncher-Oldenburg G, Cummings DE. Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations. Surg Obes Relat Dis. 2016 Jul;12(6):1144-62. PubMed PMID: 27568469
• Wang H, Wang Y, Taussig MD, Eckel RH. Sex differences in obesity development in pair-fed neuronal lipoprotein lipase deficient mice. Mol Metab. 2016 May 31;5(10):1025-32. PubMed PMID: 27689015
• de Jesus JM, Kahan S, Eckel RH. Nutrition Interventions for Cardiovascular Disease. Med Clin North Am. 2016 Nov;100(6):1251-1264. PubMed PMID: 27745593
• Wang H, Taussig MD, DiPatrizio NV, Bruce K, Piomelli D, Eckel RH. Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition. Metabolism. 2016 Jul;65(7):987-97. PubMed PMID: 27282869
• Colhoun HM, Ginsberg HN, Robinson JG, Leiter LA, Müller-Wieland D, Henry RR, Cariou B, Baccara-Dinet MT, Pordy R, Merlet L, Eckel RH. No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies. Eur Heart J. 2016 Oct 14;37(39):2981-2989. PubMed PMID: 27460890
• Wolfe BM, Kvach E, Eckel RH. Treatment of Obesity: Weight Loss and Bariatric Surgery. Circ Res. 2016 May 27;118(11):1844-55. PubMed PMID: 27230645
• Adams TD, Arterburn DE, Nathan DM, Eckel RH. Clinical Outcomes of Metabolic Surgery: Microvascular and Macrovascular Complications. Diabetes Care. 2016 Jun;39(6):912-23. PubMed PMID: 27222549
• Rubino F, Nathan DM, Eckel RH, Schauer PR, Alberti KG, Zimmet PZ, Del Prato S, Ji L, Sadikot SM, Herman WH, Amiel SA, Kaplan LM, Taroncher-Oldenburg G, Cummings DE. Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations. Diabetes Care. 2016 Jun;39(6):861-77. PubMed PMID: 27222544
• Jarvie JL, Wang H, Kinney GL, Snell-Bergeon J, Hokanson JE, Eckel RH. Lipoprotein-associated phospholipase A2 distribution among lipoproteins differs in type 1 diabetes. J Clin Lipidol. 2016 May-Jun;10(3):577-86. PubMed PMID: 27206945
• Eckel RH, Bays HE, Klein S, Bade Horn D. Proactive and Progressive Approaches in Managing Obesity. Postgrad Med. 2016 Oct;128 Suppl 1:21-30. PubMed PMID: 27153316
• Chait A, Eckel RH. Lipids, Lipoproteins, and Cardiovascular Disease: Clinical Pharmacology Now and in the Future. J Clin Endocrinol Metab. 2016 Mar;101(3):804-14. PubMed PMID: 26908111
• Eckel RH, Hokanson JE. The Prediction of Atherosclerotic Cardiovascular Disease in Type 1 Diabetes Mellitus: Do We Just Stop Here?. Circulation. 2016 Mar 15;133(11):1051-3. PubMed PMID: 26888766
• Pettus J, McNabb B, Eckel RH, Skyler JS, Dhalla A, Guan S, Jochelson P, Belardinelli L, Henry RH. Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin. Diabetes Obes Metab. 2016 May;18(5):463-74. PubMed PMID: 26749407
• Thomas EA, Mcnair B, Bechtell JL, Ferland A, Cornier MA, Eckel RH. Greater hunger and less restraint predict weight loss success with phentermine treatment. Obesity (Silver Spring). 2016 Jan;24(1):37-43. PubMed PMID: 26584649
• Al-Safi ZA, Liu H, Carlson NE, Chosich J, Harris M, Bradford AP, Robledo C, Eckel RH, Polotsky AJ. Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women. J Clin Endocrinol Metab. 2016 Jan;101(1):324-33. PubMed PMID: 26523525
• Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2016 Jun;17(4):257-65. PubMed PMID: 26080650
• Al-Safi ZA, Liu H, Carlson NE, Chosich J, Harris M, Bradford AP, Robledo C, Eckel RH, Polotsky AJ. Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women. J Clin Endocrinol Metab. 2016 Jan;101(1):324-33. PubMed PMID: 26523525
• Pettus J, McNabb B, Eckel RH, Skyler JS, Dhalla A, Guan S, Jochelson P, Belardinelli L, Henry RH. The effect of ranolazine on glycemic control in patients with type 2 diabetes treated with either glimepiride or metformin. Diabetes Obes Metab. 2016 Jan 8. [Epub ahead of print] PubMed PMID: 26749407
• Thomas EA, Mcnair B, Bechtell JL, Ferland A, Cornier MA, Eckel RH. Greater hunger and less restraint predict weight loss success with phentermine treatment. Obesity (Silver Spring). 2016 Jan;24(1):37-43. PubMed PMID: 26584649
• Eckel RH, Depner CM, Perreault L, Markwald RR, Smith MR, McHill AW, Higgins J, Melanson EL, Wright KP Jr. Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity. Curr Biol. 2015 Nov 16;25(22):3004-10. PubMed PMID: 26549253
• Cornier MA, Eckel RH. Non-traditional dosing of statins in statin-intolerant patients-is it worth a try?. Curr Atheroscler Rep. 2015 Feb;17(2):475. PubMed PMID: 25432858
• Libby AE, Wang H, Mittal R, Sungelo M, Potma E, Eckel RH. Lipoprotein lipase is an important modulator of lipid uptake and storage in hypothalamic neurons. Biochem Biophys Res Commun. 2015 Sep 18;465(2):287-92. PubMed PMID: 26265042
• Yu T, Taussig MD, DiPatrizio NV, Astarita G, Piomelli D, Bergman BC, Dell'Acqua ML, Eckel RH, Wang H. Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. PLoS One. 2015;10(8):e0135113. PubMed PMID: 26263173
• Bjornstad P, Eckel RH, Pyle L, Rewers M, Maahs DM, Snell-Bergeon JK. Relation of Combined Non-High-Density Lipoprotein Cholesterol and Apolipoprotein B With Atherosclerosis in Adults With Type 1 Diabetes Mellitus. Am J Cardiol. 2015 Oct 1;116(7):1057-62. PubMed PMID: 26251001
• Fox CS, Golden SH, Anderson C, Bray GA, Burke LE, de Boer IH, Deedwania P, Eckel RH, Ershow AG, Fradkin J, Inzucchi SE, Kosiborod M, Nelson RG, Patel MJ, Pignone M, Quinn L, Schauer PR, Selvin E, Vafiadis DK. Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association. Diabetes Care. 2015 Sep;38(9):1777-803. PubMed PMID: 26246459
• Groves DW, Krantz MJ, Hokanson JE, Johnson LR, Eckel RH, Kinney GL, Rewers M, Snell-Bergeon JK, Alman AC. Comparison of Frequency and Duration of Periodontal Disease With Progression of Coronary Artery Calcium in Patients With and Without Type 1 Diabetes Mellitus. Am J Cardiol. 2015 Sep 15;116(6):833-7. PubMed PMID: 26189036
• Eckel RH. Eggs and beyond: is dietary cholesterol no longer important?. Am J Clin Nutr. 2015 Aug;102(2):235-6. PubMed PMID: 26178728
• Eckel RH. Intestinal Lipoprotein Secretion: Incretin-Based Physiology and Pharmacology Beyond Glucose. Diabetes. 2015 Jul;64(7):2338-40. PubMed PMID: 26106196
• Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2015 Jun 17. [Epub ahead of print] PubMed PMID: 26080650
• Eckel RH, Henry RR, Yue P, Dhalla A, Wong P, Jochelson P, Belardinelli L, Skyler JS. Effect of Ranolazine Monotherapy on Glycemic Control in Subjects With Type 2 Diabetes. Diabetes Care. 2015 Jul;38(7):1189-96. PubMed PMID: 26049552
• Schlaepfer IR, Glodé LM, Hitz CA, Pac CT, Boyle KE, Maroni P, Deep G, Agarwal R, Lucia SM, Cramer SD, Serkova NJ, Eckel RH. Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Prostate Cancer Mouse Xenografts. Mol Imaging Biol. 2015 Aug;17(4):529-38. PubMed PMID: 25561013
• Cornier MA, Eckel RH. Non-traditional dosing of statins in statin-intolerant patients-is it worth a try?. Curr Atheroscler Rep. 2015;17(2):475. PubMed PMID: 25432858
• Samovski D, Sun J, Pietka T, Gross RW, Eckel RH, Su X, Stahl PD, Abumrad NA. Regulation of AMPK activation by CD36 links fatty acid uptake to ß-oxidation. Diabetes. 2015 Feb;64(2):353-9. PubMed PMID: 25157091
• Samovski D, Sun J, Pietka T, Gross RW, Eckel RH, Su X, Stahl PD, Abumrad NA. Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to ß-Oxidation. Diabetes. 2015 Feb;64(2):353-9. PubMed PMID: 25157091
• Schlaepfer IR, Glodé LM, Hitz CA, Pac CT, Boyle KE, Maroni P, Deep G, Agarwal R, Lucia SM, Cramer SD, Serkova NJ, Eckel RH. Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Prostate Cancer Mouse Xenografts. Mol Imaging Biol. 2015 Jan 6. [Epub ahead of print] PubMed PMID: 25561013
• Eckel RH. Role of glycemic index in the context of an overall heart-healthy diet. JAMA. 2014 Dec 17;312(23):2508-9. PubMed PMID: 25514301
• Bjornstad P, Maahs DM, Wadwa RP, Pyle L, Rewers M, Eckel RH, Snell-Bergeon JK. Plasma triglycerides predict incident albuminuria and progression of coronary artery calcification in adults with type 1 diabetes: the Coronary Artery Calcification in Type 1 Diabetes Study. J Clin Lipidol. 2014 Nov-Dec;8(6):576-83. PubMed PMID: 25499940
• Pellinen J, Wang H, Eckel RH. Mice with Altered Brain Lipoprotein Metabolism Display Maladaptive Responses to Envornmental Challenges that May Predispose to Obesity. Metabolic Syndrome and Relaated Disorders, In Press, 2014.
• Wang H, Eckel RH. What are lipoproteins doing in the brain?. Trends Endocrinol Metab. 2014 Jan;25(1):8-14. PubMed PMID: 24189266
• Wang H, Capell W, Yoon JH, Faubel S, Eckel RH. Obesity development in caspase-1-deficient mice. Int J Obes (Lond). 2014 Jan;38(1):152-5. PubMed PMID: 23689355
• Eckel RH, Cornier MA. Update on the NCEP ATP-III emerging cardiometabolic risk factors. BMC Med. 2014 Aug 26;12:115. PubMed PMID: 25154373
• Schlaepfer IR, Rider L, Rodrigues LU, Gijón MA, Pac CT, Romero L, Cimic A, Sirintrapun SJ, Glodé LM, Eckel RH, Cramer SD. Lipid catabolism via CPT1 as a therapeutic target for prostate cancer. Mol Cancer Ther. 2014 Oct;13(10):2361-71. PubMed PMID: 25122071
• de Ferranti SD, de Boer IH, Fonseca V, Fox CS, Golden SH, Lavie CJ, Magge SN, Marx N, McGuire DK, Orchard TJ, Zinman B, Eckel RH. Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart Association and American Diabetes Association. Diabetes Care. 2014 Oct;37(10):2843-63. PubMed PMID: 25114297
• de Ferranti SD, de Boer IH, Fonseca V, Fox CS, Golden SH, Lavie CJ, Magge SN, Marx N, McGuire DK, Orchard TJ, Zinman B, Eckel RH. Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart Association and American Diabetes Association. Circulation. 2014 Sep 23;130(13):1110-30. PubMed PMID: 25114208
• Eckel RH. LDL cholesterol as a predictor of mortality, and beyond: to fast or not to fast, that is the question?. Circulation. 2014 Aug 12;130(7):528-9. PubMed PMID: 25015339
• Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S. Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry. 2014 Oct;19(10):1095-105. PubMed PMID: 24732670
• Pellinen J, Wang H, Eckel RH. Mice with altered brain lipoprotein metabolism display maladaptive responses to environmental challenges that may predispose to weight gain. Metab Syndr Relat Disord. 2014 Aug;12(6):339-46. PubMed PMID: 24730656
• Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PW, American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2889-934. PubMed PMID: 24239923
• Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Houston Miller N, Hubbard VS, Lee IM, Lichtenstein AH, Loria CM, Millen BE, Nonas CA, Sacks FM, Smith SC Jr, Svetkey LP, Wadden TA, Yanovski SZ, American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2960-84. PubMed PMID: 24239922
• Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PW, Eddleman KM, Jarrett NM, LaBresh K, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF, American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014 Jun 24;129(25 Suppl 2):S1-45. PubMed PMID: 24222016
• Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Houston Miller N, Hubbard VS, Lee IM, Lichtenstein AH, Loria CM, Millen BE, Nonas CA, Sacks FM, Smith SC Jr, Svetkey LP, Wadden TA, Yanovski SZ, Kendall KA, Morgan LC, Trisolini MG, Velasco G, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF, American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014 Jun 24;129(25 Suppl 2):S76-99. PubMed PMID: 24222015
• Wang H, Eckel RH. What are lipoproteins doing in the brain?. Trends Endocrinol Metab. 2014 Jan;25(1):8-14. PubMed PMID: 24189266
• Wang H, Capell W, Yoon JH, Faubel S, Eckel RH. Obesity development in caspase-1-deficient mice. Int J Obes (Lond). 2014 Jan;38(1):152-5. PubMed PMID: 23689355
• Meschia JF, Bushnell C, Boden-Albala B, Braun LT, Bravata DM, Chaturvedi S, Creager MA, Eckel RH, Elkind MS, Fornage M, Goldstein LB, Greenberg SM, Horvath SE, Iadecola C, Jauch EC, Moore WS, Wilson JA, American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Functional Genomics and Translational Biology, Council on Hypertension. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014 Dec;45(12):3754-832. PubMed PMID: 25355838
• Lim S, Eckel RH. Pharmacological treatment and therapeutic perspectives of metabolic syndrome. Rev Endocr Metab Disord. 2014 Dec;15(4):329-41. PubMed PMID: 25342235
• Eckel RH. What is it about very low density lipoproteins (VLDL) and cardiovascular disease in patients with type 2 diabetes mellitus: is it the triglycerides or the cholesterol?. Atherosclerosis. 2014 Nov;237(1):138-9. PubMed PMID: 25238222
• Markwald RR, Melanson EL, Smith MR, Higgins J, Perreault L, Eckel RH, Wright KP Jr. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5695-700. PubMed PMID: 23479616
• Han SH, Oh PC, Lim S, Eckel RH, Koh KK. Comparative cardiometabolic effects of fibrates and omega-3 fatty acids. Int J Cardiol. 2013 Sep 10;167(6):2404-11. PubMed PMID: 23452884
• Bergman BC, Howard D, Schauer IE, Maahs DM, Snell-Bergeon JK, Clement TW, Eckel RH, Perreault L, Rewers M. The Importance of Palmitoleate Acid to Adipocyte Insulin Resistance and Whole-Body Insulin Sensitivity in Type 1 Diabetes. Journal of Clinical Endocrinology and Metabolism, 98:E40-50, 2013.
• Han SH, Oh PC, Lim S, Eckel RH, Kwang KK. Comparative Cardiometabolic Effects of Fibrates and Omega-3 Fatty Acids. International Journal of Cardiology, In Press, 2013.
• Markwald RR, Melanson EL, Smith MR, Higgins J, Perreault L, Eckel RH, Wright KP. Impact of insufficient sleep on total daily energy expenditure, food intake and weight gain. Proc Natl Acad Sci USA, March 11, 2013.
• de Ferranti SD, de Boer IH, Fonseca V, Fox CS, Golden SH, Lavie CJ, Magge SN, Marx N, McGuire DK, Orchard TJ, Zinman B, Eckel RH. Type 1 Diabetes Mellitus and Cardiovascular Disease: A Joint AHA/ADA Scientific Statement. Circulation, In Press, 2013.
• Maahs DM, Eckel RH. Type 1 Diabetes and Dyslipidemia. In Dyslipidemias: Pathophysiology, Evaluation and Management, Abhimanyu Garg, Ed, Springer Press, In Press, 2013
• Stone NJ, Robinson J, Lichtenstein AH, Bairey Merz CN, Lloyd-Jones DM, Blum CB, McBride P, Eckel RH, Schwartz JS, Goldberg AC, Shero ST, Gordon D, Smith SC Jr, Levy D, Watson K, Wilson PW. 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013 Nov 7. [Epub ahead of print] PubMed PMID: 24239923
• Eckel RH, Jakicic JM, Ard JD, Miller NH, Hubbard VS, Nonas CA, de Jesus JM, Sacks FM, Lee IM, Smith SC Jr, Lichtenstein AH, Svetkey LP, Loria CM, Wadden TW, Millen BE, Yanovski SZ. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013 Nov 7. [Epub ahead of print] PubMed PMID: 24239922
• Stone NJ, Robinson J, Lichtenstein AH, Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PW. 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2013 Nov 12. [Epub ahead of print] PubMed PMID: 24222016
• Eckel RH, Jakicic JM, Ard JD, Hubbard VS, de Jesus JM, Lee IM, Lichtenstein AH, Loria CM, Millen BE, Miller NH, Nonas CA, Sacks FM, Smith SC Jr, Svetkey LP, Wadden TW, Yanovski SZ. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2013 Nov 12. [Epub ahead of print] PubMed PMID: 24222015
• Eckel RH, Eisenbarth GS. Autoimmune Diabetes Inflames the Heart, Science Translational Medicine, 13:4(138):138fs18, 2012.
• Wang H, Eckel RH. Lipoprotein Lipase in the Brain and Nervous System. Annual Review of Nutrition, 32:147-160, 2012.
• Eckel RH, CVD Health Factors and CVD Risk Factors: State of the Science, Emerging Priorities Part 2: Obesity Prevention. Ethnicity and Disease, 22 (Suppl 1):S1-38-40, 2012.
• Ferland A, Chateau-Degat M-L, Hernandez TL, Eckel RH. Relationship of Tissue-Specific Responses of Lipoprotein Lipase to Dietary Macronutrient Composition as a Predictor of Weight Gain over Four Years. Obesity, In Press, 2012 Jan 19 Epub..
• Morino K, Petersen KF, Sono S, Choi CS, Samuel VT, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg IJ, Wang H, Eckel RH, Maegawa H, Shulman GI. Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insuliln Resistant Offspring of Parents with Type 2 Diabetes. Diabetes, In Press, 2012 Feb 24, Epub.
• Bergman BC, Howard D, Schauer IE, Maahs DM, Snell-Bergeon JK, Eckel RH, Perreault L Rewers M. Features of Hepatic and Skeletal Muscle Insulin Resistance Unique to Type 1 Diabetes. Journal of Clinical Endocrinology and Metabolism, In Press, 2012, Feb 22 Eoub..
• Ferland A, Chateau-Degat M-L, Hernandez TL, Eckel RH. Relationship of Tissue-Specific Responses of Lipoprotein Lipase to Dietary Macronutrient Composition as a Predictor of Weight Gain over Four Years. Obesity, 20:1006-1011, 2012..
• Lynch AM, Eckel RH, Murphy JR, Gibbs RS, West NA, Giclas PC, Salmon JE, Holers VM. Prepregnancy Obesity and Complement System Activation in Early Pregnancy and the Subsequent Development of Preeclampsia. American Journal of Obstetrics and Gynecology, 206:428e1-8, 2012.
• Morino K, Petersen KF, Sono S, Choi CS, Samuel VT, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg IJ, Wang H, Eckel RH, Maegawa H, Shulman GI. Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insuliln Resistant Offspring of Parents with Type 2 Diabetes. Diabetes 61:877-887, 2012.
• Bergman BC, Howard D, Schauer IE, Maahs DM, Snell-Bergeon JK, Eckel RH, Perreault L Rewers M. Features of Hepatic and Skeletal Muscle Insulin Resistance Unique to Type 1 Diabetes. Journal of Clinical Endocrinology and Metabolism, 97:1663-1672, 2012.
• Abdel-Maksoud MF, Eckel RH, Hamman RF, Hokanson JE. CHD Risk is Associated with Triglycerides and HDL in Women and Non-HDL Cholesterol in Men. J, Clinical Lipidology 4:374-381, 2012.
• Rehrer CW, Karimpour-Fard A. Hernandez TL, Law CK, Stob N, Hunter L, Eckel RH, Regional Differences in Subcutaneous Adipose Tissue Gene Expression, Obesity, 20:2168-2173, 2012.
• Bergman BC, Perreault L, Hunerdosse D, Kerage A, Playdon M, Samek AM, Eckel RH. Novel and Reversible Mechanisms of Smoking-Induced Insulin Resistance in Humans. Diabetes, 61:3156-3166, 2012.
• Robciuc MR, Skrobuk P, Anisimov A, Olkkon V, Alitalo K, Eckel RH, Kostinen HA, Jauhiainen M, Ehnholm C. Angiopoietin-like 4 Mediates Peroxisome Proliferator-activated Receptor Delta Effect on Lipoprotein Lipase-dependent Fatty Acid Uptake but Not Beta-oxidation in Myotubes. PlosONE, e46212. Epub Oct 4, 2012.
• Schlaepfer IR, Hitz CA, Gijon MA, Bergman BC, Eckel RH, Jacobsen BM. Progestin Modulates the Lipid Profile and Sensitivity of Breast Cancer cells to Docetaxel. Molecular and Cellular Endocrinology 363:111-121, 2012.
• Walker AE, Kaplon RE, Lucking SMS, Russell-Nowlan MJ, Eckel RH, Seals DR. Fenofibrate Improves Vascular Endothelial Function by Reducing Oxidative Stress While Increasing eNOS in Healthy Normolipidemic Older Adults. Hypertension 60: 1517-1523, 2012.
• 45. Eckel RH. Editor of Metabolic Risk for Cardiovascular Disease. American Heart Association Clinical Series. Oxford, Wiley-Blackwell, 2011
• Eckel RH. The Complex Metabolic Mechanisms Relating Obesity to Hypertriglyceridemia. Arteriosclerosis,Thrombosis and Vascular Biology, 31:1946-1948, 2011.
• 46. Nadeau KJ, Maahs DM, Daniels SR, Eckel RH. Childhood Obesity and Cardiovascular Disease: Links and Prevention Strategies. 2011. Nature Reviews Cardiology, 14:513-525, 2011.
• Ferland A, Eckel RH. Does Sustained Weight Loss Reverse the Metabolic Syndrome? Current Hypertension Reports, 13(6):458-464, 2011.
• Wang H, Astarita G, Taussig MD, Bharadwaj KG, DiPatrizio NV, Nave K-A, Piomelli D, Goldberg IJ, Eckel RH. Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity. Cell Metabolism, 9:105-113, 2011.
• Jung CM, Melanson EL, Frydendall EJ, Perreault L, Eckel RH, Wright K. Energy Expenditure During Sleep Deprivation and Sleep Following Sleep Deprivation in Adult Humans. The Journal of Physiology, Epub Nov 8, 2010.
• . Perreault L, Bergman BC, Hunerdosse DM, Howard DJ Eckel RH. Fenofibrate Administration Does Not Affect Muscle Triglyceride Concentration or Insulin Sensitivity in Humans. Metabolism, In Press.
• Hernandez TL, Kittelson JM, Law CK, Ketch LL, Stob NR, Lindstrom RC, Scherzinger A, Stamm ER, Eckel RH. Fat Distribution Following Suction Lipectomy: Defense of Body Fat and Patterns of Restoration. Obesity, In Press.
• Eckel RH, Kahn SE, Ferrannini E, Godlfine AB, Nathan DM, Schwartz MW, Smith RJ, Smith SR. Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to be Individualized? Journal of Clinical Endocrinology and Metabolism, 2011, In Press.
• Eckel RH. Editor of Metabolic Risk for Cardiovascular Disease. American Heart Association Clinical Series. Oxford, Wiley-Blackwell, 2011.
• Nadeau KJ, Maahs DM, Daniels SR, Eckel RH. Childhood Obesity and Cardiovascular Disease: Links and Prevention Strategies. 2011. Nature Reviews Cardiology, In Press.
• Schauer IE, Snell-Bergeon JK, Bergman BC, Maahs DM, Kretowski A, Eckel RH, Rewers, M. Insulin Insulin Resistance, Defective Isulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects with and without Type 1 Diabetes: The CACTI Study. Diabetes, 60:306-314, 2011.
• Wang H, Astarita G, Taussig MD, Bharadwaj KG, DiPatrizio NV, Nave K-A, Piomelli D, Goldberg IJ, Eckel RH. Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity. Cell Metabolism, 13:105-113, 2011.
• Perreault L, Bergman BC, Hunerdosse DM, Howard DJ Eckel RH. Fenofibrate Administration Does Not Affect Muscle Triglyceride Concentration or Insulin Sensitivity in Humans. Metabolism, 60:1107-1114, 2011.
• Hernandez TL, Kittelson JM, Law CK, Ketch LL, Stob NR, Lindstrom RC, Scherzinger A, Stamm ER, Eckel RH. Fat Distribution Following Suction Lipectomy: Defense of Body Fat and Patterns of Restoration. Obesity, 19:1388-1395, 2011.
• Eckel RH, Kahn SE, Ferrannini E, Goldfine AB, Nathan DM, Schwartz MW, Smith RJ, Smith SR. Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to be Individualized? Jointly Published in Journal of Clinical Endocrinology and Metabolism 96:1654-1663, 2011 and Diabetes Care, 34:1424-1430, 2011.
• Goldberg IJ, Eckel RH, McPherson R. Triglycerides and Heart Disease, Still a Hypothesis? Arteriosclerosis, Thrombosis, and Vascular Biology, 31:1716-1725, 2011.
• Cornier M-A, Marshall JA, Hill JO, Maahs DM, Eckel RH. The Prevention of Overweight/Obesity as a Strategy to Optimize Cardiovascular Health. Circulation, 124:840-850, 2011.
• Kinney GL, Snell-Bergeon JK, Maahs DM, Eckel RH, Ehrlich J, Rewers M, Hokanson JE. Lipoprotein-Associated Phospholipase A2 Activity Predicts Progression of Subclinical Coronary Atherosclerosis. Diabetes Technology and Therapeutics 13:381-387, 2011.
• Lynch AM, Eckel RH, Murphy JR, Gibbs RS, West NA, Giclas PC, Salmon JE, Holers VM. Prepregnancy Obesity and Complement System Activation in Early Pregnancy and the Subsequent Development of Preeclampsia. American Journal of Obstetrics and Gynecology, In Press, 2011
• Steig AJ, Jackman MR, Giles ED, Higgins JA, Johnson GC, Mahan C, Melanson EL, Wyatt HR, Eckel RH, Hill JO, Maclean PS. Exercise Reduces Appetite and Traffics Excess Nutrients away from Energetically Efficient Pathways of Lipid Deposition during the Early Stages of Weight Regain. American Journal of Regulatory Integrated Comparative Physiology In Press, 2011.
• Steig AJ, Jackman MR, Giles ED, Higgins JA, Johnson GC, Mahan C, Melanson EL, Wyatt HR, Eckel RH, Hill JO, Maclean PS. Exercise Reduces Appetite and Traffics Excess Nutrients away from Energetically Efficient Pathways of Lipid Deposition during the Early Stages of Weight Regain. American Journal of Regulatory Integrated Comparative Physiology 301:R656-667, 2011.
• Tschöp MH, Speakman JR, Arch JRS, Auwerx J, Bruning JC, Chan L, Eckel RH, Farese RC Jr. Galgani JE, Hambly C, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Muller, Muenzberg H, Pfluger PT, Plum L, Reitman M, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin EA Guide to Analysis of Mouse Energy Metabolism; Nature Methods,28:57-63, 2011.
• Kaul S, Bolger AF, Herrington D, Giugliano R, Eckel RH. Advisory on Thiazolidinedione Drugs and Cardiovascular Risks. Circulation. In Press.
• Kaul S, Bolger AF, Herrington D, Giugliano RP, Eckel RH. Thiazolidinedione Drugs and Cardiovasular Risks. Circulation. In Press.
• Hernandez TL, Sutherland JP, Wolfe P, Allian-Sauer M, Capell WH, Talley ND, Wyatt HR, Foster G, Hill JO, Eckel RH. Lack of Suppression of Circulating Free Fatty Acids and Hypercholesterolemia During Weight Loss on a High Fat, Low Carbohydrate Diet. American Journal of Clinical Nutrition, 91:578-585, 2010.
• Kaul S, Bolger AF, Herrington D, Giugliano R, Eckel RH. Advisory on Thiazolidinedione Drugs and Cardiovascular Risks. Circulation. 121(16):1868-1877, 2010.
• Levine GN, D’Amico AV, Berger P, Clark PE, Eckel RH, Keating NL Milani RV, Sagalowsky AI, Smith MR, Zakai N. Androgen Deprivation in Prostate Cancer and Cardiovascular Risk. Circulation.121:833-840, 2010.
• RH. Approach to the Patient Who is Intolerant of Statin Therapy. Journal of Clinical Endocrinology and Metabolism. 95(5):2015-2022, 2010.
• Perreault L, Bergman BC, Hunerdosse DM, Eckel RH. Altered Intramuscular Lipid Metabolism Relates to Diminished Insulin Action in Men, But Not Women, in Progression to Diabetes. Obesity, Epub Apr 8, 2010.
• Bergman BC, Perreulat L, Hunerdosse DM, Eckel RH. Increased Intramuscular Lipid Synthesis and Low Saturation Relate to Insulin Sensitivity in Endurance-Trained Athletes. J. Appl Phys, 108(5):1134-1141, 2010.
• Donahoo WT, Stob NR, Ammon S, Levin N. Eckel RH. Leptin Increases Skeletal Muscle Lipoprotein Lipase and Postprandial Lipid Metabolism in Mice. Metabolism, Epub May 20, 2010.
• Maahs DM, Hokanson JE, Wang H, Kinney GL, Snell-Bergeon JK, East A, Bergman B, Schauer IE, Rewers M, Eckel RH. Lipoprotein Subfraction Cholesterol Distribution is Pro-Atherogenic in Women with Type 1 Diabetes and Insulin Resistance. Diabetes. 59(7):1771-1779, 2010.
• Capell WH, Schlaepfer IR, Wolfe P, Watson PA, Bessesen DH, Pagliasotti MJ, Eckel RH. Fatty acids Increase Glucose Uptake and Metabolism in C2C12 Myoblasts Stably Transfected with Human Lipoprotein Lipase. American Journal of Physiology, Endocrinology and Metabolism, American Journal of Physiology Endocrinology and Metabolism. 299(4):E576-583. 2010.
• . Schauer IE, Snell-Bergeon JK, Bergman BC, Maahs DM, Kretowski A, Eckel RH, Rewers, M. Insulin Insulin Resistance, Defective Isulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects with and without Type 1 Diabetes: The CACTI Study. Diabetes, Epub Oct 26.2010.
• Bergman BC, Perreulat L, Hunerdosse DM, Eckel RH. Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes. J. Appl Phys, In Press.
• Perreault L, Bergman BC, Hunerdosse DM, Eckel RH. Altered Intramuscular Lipid Metabolism Relates to Diminished Insulin Action in Men, But Not Women, in Progression to Diabetes. Obesity, In Press.
• Eckel RH. Approach to the Patient Who is Intolerant of Statin Therapy. Journal of Clinical Endocrinology and Metabolism. In Press.
• Levine GN, D’Amico AV, Berger P, Clark PE, Eckel RH, Keating NL Milani RV, Sagalowsky AI, Smith MR, Zakai N. Androgen Deprivation in Prostate Cancer and Cardiovascular Risk. Circulation, 2010; 121:831-838.
• Hernandez TL, Sutherland JP, Wolfe P, Allian-Sauer M, Capell WH, Talley ND, Wyatt HR, Foster G, Hill JO, Eckel RH. Lack of Suppression of Circulating Free Fatty Acids and Hypercholesterolemia During Weight Loss on a High Fat, Low Carbohydrate Diet. American Journal of Clinical Nutrition, In Press.
• Perreault L, Bergman BC, Hunerdosse DM, Playton MC, Eckel RH. Inflexibility in Intramuscular Triglyceride Fractional Synthesis Distinguishes Pre-Diabetes from Obesity in Humans. Obesity. In Press.
• Eckel RH, Alberti KGMM, Grundy SM, Zimmet PJ. Metabolic Syndrome Update. The Lancet, 2010; 375:181-183.
• Eckel RH. The Fish Oil Story Remains Fishy. Circulation, In Press, 2010.
• Alberti KGMM, Eckel RH, Grundy SM, Zimmet PJ, Cleeman JI, Donato KA, Fruchart JC, James PT, Loria CM, Smith SA. Harmonizing the Metabolic Syndrome: A Joint Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart. Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the study of Obesity. Circulation,2009; 120:1640-1645.
• Bergman BC, Perreault L, Hunerdosse DM, Koehler MC, Samek AM, Eckel RH. Intramuscular Lipid Metabolism in the Insulin Resistance of Smoking. Diabetes 2009; 58:2220-2227.
• Lewis CE, McTigue KM, Burke LE, Poirier P, Eckel RH, Howard BV, Allison DB, Kumanyika S, Pi-Sunyer FX. Mortality, Health Outcomes, and Body Mass Index in the Overweight Range: A Science Advisory from the American Heart Association. Circulation, 2009;119 3263-3271.
• Daniels SR, Jacobson MS, McCrindle BW, Eckel RH, Sanner BM. American Heart Association Childhood Obesity Research Summit: Executive Summary. Circulation 2009 119:2114-2123.
• Wang H, Eckel RH. Lipoprotein Lipase: From Gene to Obesity. Amer. J. Physiology Endocrinology and Metabolism, 2009; 297:E271-E288.
• Wang H, Knaub LA, Jensen DR, Jung DY, Hong E-G, Ko H-J, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Choi CS, Shulman GI, Kim JK, Friedman JE, Eckel RH. Skeletal Muscle-Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues. Diabetes, Jan;58(1):116-124, 2009.
• Steinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, McCrindle B, Mietus-Snyder ML. Progress and Challenges in Metabolic Syndrome in Children and Adolescents. Circulation, Feb 3;119(4):628-647, 2009.
• Denberg TD, Myers BA, Eckel RH, McDermott MT, Dickinson WP, Lin C-T, A Patient Outreach Program Between Visits Improves Diabetes Care. International Journal of Health Care, 2008 Dec 24. Epub.
• Eckel RH, Kris-Etherton P, Lichtenstein AH, Wylie-Rosett J, Groom A, Stitzel KF, Yin-Piazza S. Americans’ Awareness, Knowledge and Behaviors Regarding Fats: 2006-2007. J. American Dietetics Association, Feb:109(2):288-296, 2009.
• . Donahoo WT, Hernandez TL, Costa JL, Jensen DR, Morris AM, Brennan MB, Hochgeschwender U, Eckel RH. Plasma ?-Melanocyte Stimulating Hormone (?-MSH): Gender Differences and Correlations with Obesity. Metabolism, Jan;58(1):16-21, 2009.
• Snell-Bergeon JK, Chartier-Logan C, Maahs DM, Ogden LG, Hokanson JE, Kinney GL, Eckel RH, Ehrlich J, Rewers M. Adults with Type 1 Diabetes Eat a High-Fat Atherogenic Diet that is Associated with Coronary Artery Calcium. Diabetologia, 2009 Feb 14 Epub.
• Eckel RH. Obesity research in the next decade. Int Journal of Obesity 32:S143-S151, 2008.
• Hernandez TL, Ballard RD, Weil KM, Shepard TY, Scherzinger AL, Stamm ER, Sharp TA, Eckel RH. Effects of Maintained Weight Loss on Sleep Dynamics and Neck Morphology in Severely Obese Adults. Obesity, Jan;17(1):84-91, 2009.
• Bergman BC, Cornier, M-A, Horton TJ, Bessesen DH, Eckel RH. Skeletal Muscle Munc 18c and Syntaxin 4 in Human Obesity. Nutrition and Metabolism, 2008 Jul 24;5:21, Epub.
• Perreault L, Bergman BC, Playdon MC, Chiara DM, Cabelli C, Eckel RH. Impaired Fasting Glucose with r without Impaired Glucose Tolerance: Progressive or Parallel States of Pre-Diabetes. American Journal of Physiology-Endocrinology and Metabolism, Aug;295(2):E428-35, 2008
• Linnebur SA, Capell WH, Saseen JJ, Wolfe P, Eckel RH. Plant sterols added to combination statin and colesevalam hydrochloride therapy failed to lower low-density lipoprotein cholesterol concentrations. J Clin Lipidolgy, In Press.
• Jensen DR, Knaub LA, Konhilas JP, Leniwand LA, Maclean PS, Eckel RH. Increased thermoregulation in cold exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: An avian phenotype? Journal of Lipid Research, In Press.
• 24. Eckel RH. Egg Consumption in Relation to Cardiovascular Disease and Mortality: The Story Gets More Complex. American Journal of Clinical Nutrition, 2008 In Press.
• Eckel RH. Egg Consumption in Relation to Cardiovascular Disease and Mortality: The Story Gets More Complex. American Journal of Clinical Nutrition, 87(4):799-800, 2008.
• Cornier M-A, Dabalea D, Hernandez T, Lindstrom R, Steig AJ, Stob NR, Van Pelt RE, Wang H, Eckel RH. The Metabolic Syndrome. Endocrine Reviews, Dec:29(7):777-822, 2008.
• Poirier P, Eckel RH. Cardiovascular Consequences of Obesity. Drug Discovery Today: Therapeutic Strategies. 5:45-51, 2008.
• Eckel RH. Non-surgical management of obesity in adults. New England Journal of Medicine
• 40. Eckel RH. Mechanisms of the components of the metabolic syndrome that predispose to diabetes and atherosclerotic CVD. Proc Nutr Soc, 66:1-13, 2007
• 7-8
• Eckel RH. Treating the dyslipidemia of the metabolic syndrome: where’s the evidence? Nature Clinical Practice Endocrinology and Metabolism, 2007 Jun;3(6):437.
• Eckel RH. Mechanisms of the components of the metabolic syndrome that predispose to diabetes and atherosclerotic CVD. Proc Nutr Soc, 66:1-13, 2007
• Morris AM, Poirier P, Eckel RH. Obesity and the Heart. IN: Adipose Tissue and Adipokines in Health and Disease. Ed. Fantuzzi G, Totowa, N.J. : Humana Press, p. 23, c2007.
• 163. Schroeder-Gloecker* J, Rahman* SM, Janssen R., Shao J, Qiao L, Roper M, Fisher S, Lowe E, Orlicky D, Mcmanaman J, Palmer C, Gitomer WL, Huang W, O’Dohrety RM, Becker TC, Klemm DJ, Jensen DR, Pulawa L, Eckel RH, Friedman JE. CCAAT/Enhancer Binding Protein ß (C/EBPß) deletion reduces adiposity, hepatic steatosis, and hyperglycemia in Lepr db/db mice. Journal of Biological Chemistry, 2007 May 25;282(21):15717-29. Epub 2007 Mar 26.
• Maahs DM, Ogden LG, Snell-Bergeon JK, Kinney GL, Wadwa RP, Hokanson JE, Dana Dabelea D, Kretowski A, Eckel RH, Rewers M. Determinants of Serum Adiponectin in Persons with and without Type 1 Diabetes American Journal of Epidemiology,, 2007 Sep 15;166(6):731-40. Epub 2007 Jun 24.
• Eckel RH, Borra S, Lichtenstein AH, Yin-Piazza SY. Understanding the Complexity of Trans Fatty Acid Reduction in the American Diet. American Heart Association Trans Fat Conference 2006. Report of the Trans Fat Conference Planning Group. Circulation, 2007 Apr 24;115(16):2231-46. Epub 2007 Apr 10.
• Hajri T, Jensen DR, Pietka T, Drover V, Pietka TA, Tao H, Eckel RH, Abumrad NA. Fatty acid sensing and leptin release : CD36 deficiency protects against adiposity and diet-induced obesity by decreasing PPAR gamma activity and increasing leptin secretion. Diabetes, 2007 Jul;56(7):1872-80. Epub 2007 Apr 17.
• Kretowski A, McFann K, Hokanson JE, Maahs DM, Kinney GL, Snell-Bergeon JK, Wadwa RP, Eckel RH, Ogden LG, Garg SK, Li J, Cheng S, Erlich HA, Rewers M. Polymorphisms of The Renin-Angiotensin System Genes Predict Progression of Subclinical Coronary Atherosclerosis. Diabetes.
• Pulawa LK, Jensen DR, Coates A, Eckel RH. Dose-dependent reduction of plasma triglycerides in apolipoprotein CII transgenic mice with skeletal muscle specific overexpression of lipoprotein lipase. Journal of Lipid Research, 2007 Jan 48(1):145-151.
• Yokayama M, Seo T, Park T, Yagyu H, Hu Y, Son NH, Augustus AS, Vikramadythian RK, Ramakrishnan R, Pulawa LK, Eckel RH, Goldberg IJ. Cholesterol uptake into heart and skeletal muscle of lipoprotein lipase transgenic mice: Evidence that statin therapy increases muscle lipid uptake. Journal of Lipid Research
• Buse JB, Ginsberg H, Bakris GL, Clark NG, Costa F, Eckel RH, Fonseca V, Gerstein HC, Grundy S, Nesto RW, Pignone MP, Plutzky J, Porte D, Redberg R, Stitzel KF, Stone NJ. Primary Prevention of Cardiovascular Diseases in People with Diabetes Mellitus: A Scientific Statement from the American Heart Association and the American Diabetes Association. Circulation 2007 Jan 115: 114-126.
• Eckel RH. Management of Obesity in Adults. New England Journal of Medicine.
• Douglas PS, Eckel RH, Gray DT, Loeb JM, Straube BM. Coming together to achieve quality cardiovascular care. Circulation. Feb 2006; 113: 607 – 608.
• Gibbons RJ, Eckel RH, Jacobs AK. American Heart Association Science Advisory and Coordinating Committee. The utilization of cardiac imaging. Circulation. 2006 Apr 4;113(13):1715-6.
• Eckel RH. Preventive cardiology by lifestyle intervention: opportunity and/or challenge? Presidential address at the 2005 American Heart Association Scientific Sessions. Circulation. 2006;113:2657-2661.
• Eckel RH, Kahn R, Robertson RM, Rizza RA. Preventing Cardiovascular Disease and Diabetes: A call to action from the American Diabetes Association and the American Heart Association. Diabetes Care. 2006 Jul;29(7):1697-9.
• Capell WH and Eckel RH. 2006. Treatment of hypertriglyceridemia. Curr Diab Reports 6: 230-40.
• Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer X, Eckel RH. Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss; An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006 Feb 14;113(6):898-918.
• Eckel RH, Hernandez TL, Bell ML, Weil KM, Shepard TY, Grunwald GK, Sharp TA, Francis CC, and Hill JO. Carbohydrate balance predicts weight and fat gain in adults. Am J Clin Nutr, 2006; 83: 803 – 808.
• Morris AM, Sennello JA, Fayad RA, Eckel RH, Dinarello CA, Fantuzzi G. T cell-mediated hepatic inflammation modulates adiponectin levels in mice: role of tumor necrosis factor alpha. Metabolism. 2006 Apr;55(4):555-9.
• Netea MG, Joosten LAB, Lewis E, Jensen DR, Voshol PJ, Fantuzzi G, Kullberg BJ, Tack CJ, van Krieken H, Kim S-H, Stalenhoef AF, van de Loo FA, Verschueren I, Pulawa L, Akira S, Eckel RH, Dinarello CA, van den Berg W, van der Meer JWM. Deficiency of interleukin-18 in mice leads to obesity, insulin resistance, and hyperglycemia. Nat Med. 2006 Jun;12(6):650-6. Epub 2006 May 28.
• Kretowski A, Hokanson JE, McFann K, Kinney GL, Snell-Bergeon JK, Maahs DM, Wadwa RP, Eckel RH, Ogden LG, Garg SK, Li J, Cheng S, Erlich HA, Rewers M. The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes. Diabetologia. 2006 Aug;49(8):1946-54. Epub 2006 Jun 13.
• Bergman BC, Jensen DR, Pulawa LK, Ferreira LD, Eckel RH. Fasting decreases free fatty acid turnover in mice overexpressing skeletal muscle lipoprotein lipase. Metabolism. 2006 Nov;55(11): 1481-1487.
• Hernandez TL, Capell WH, Wolfe P, Gerard LA, Eckel RH. Time Course of C-reactive protein reduction with simvastatin therapy in patients with type 2 diabetes mellitus. Am J Cardiol. 2006 Dec 15;98(12):1656-9..
• Maahs DM, Wadwa RP, McFann K, Nadeau K, Williams MR, Eckel RH, Klingensmith GJ. Longitudinal Lipid Screening and Use of Lipid-Lowering Medications in Pediatric Type 1 Diabetes. The Journal of Pediatrics. 2007;150:146-150.
• Obesity, Dyslipoproteinemia, and Inflammation
• Eckel RH and Grundy SM. Insensitivity to insulin and obesity: the underlying cause. Diabetes Voice, special issue. 51; 28-30, 2006.

Professional Memberships

• Amercian Diabetes Association, Board member
• The Endocrine Society, Member
• American Heart Association, Past President, Fellow
• Naitonal Lipid Association, Fellow
• The Obesity Society, Past President, Fellow

Practice Locations

• University of Colorado Hospital

Specialty Information

• Endocrinology, Diabetes and Metabolism, Board Certification
• Internal Medicine, Board Certification

• Endocrine System (Hormones)
• Heart and Circulation
• Food, Nutrition and Metabolism - Obesity
• Endocrine System (Hormones) - Adult Type 1 Diabetes
• Endocrine System (Hormones) - Adult Type 2 Diabetes
• Endocrine System (Hormones) - Pancreatitis
• Food, Nutrition and Metabolism - Nutrition
• Food, Nutrition and Metabolism
• Food, Nutrition and Metabolism - Weight Loss and Dieting
• Heart and Circulation - Heart Diseases - Prevention
• Heart and Circulation - High Blood Pressure