Mary Weiser-Evans, PhD

Professor, Medicine-Renal Med Diseases/Hypertension

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Graduate Schools
  • MS, Colorado State University (1990)
  • PhD, Colorado State University (1992)
Fellowships
  • University of Colorado, Cardiology (1996)
Department
Medicine-Renal Med Diseases/Hypertension

Professional Titles

  • Charles Boettcher II Professor of Medicine

Publications

  • Valentina d’Escamard, Daniella Kadian-dodov, Lijiang Ma, Shouneng Peng, Annette King, Allison Thomas, Bhargravi Vonguru, Yang Xu, Katherine C. Michelis, Emir Bander, Rihab Bouchareb, Adrien Georges, Aya Nomura-Kitabayashi, Yu Zhou, Elena Chepurko, Vadim, Chepurko, Marika Fava, Temo Barwan, Anelechi Anyanwu, Farzan Filsoufi, Sander Florman, Nabila Bouatia-Naji, Manuel Mayr, Michael G. Katz, Ke Hao, Johan LM Björkegren, Sizhao Lu, Mary CM Weiser-Evans, Jeffrey Olin, Jason Kovacic (2024) Integrative Gene Regulatory Network Analysis Discloses Key Driver Genes of Fibromuscular Dysplasia in Females: the DEFINE-FMD study. Nature Cardiovasc Research, 2024; 3(9):1098-1122.
  • Batan D, Tseropoulos G, Bishop C, Kirkpatrick BE, Bera K, Khang A, Weiser-Evans M, Anseth KS (2024) PTEN Regulates Myofibroblast Activation in Valvular Interstitials Cells based on Subcellular Localization. bioRxiv [Preprint]. Aug 28:2024.06.30.601424.
  • Sizhao Lu, Austin J Jolly, Allison M Dubner, Keith A Strand, Marie F Mutryn, Tysen Noble, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary CM Weiser-Evans (2024) KLF4 in smooth muscle cell-derived progenitor cells is essential for angiotensin II-induced cardiac inflammation and fibrosis. bioRxiv [Preprint]. Jun 6:2024.06.04.597485.
  • PMC9849673
  • Austin J. Jolly, Sizhao Lu, Allison M. Dubner, Keith A. Strand, Marie F. Mutryn, Aaron Pilotti-Riley, Etienne P. Danis, Raphael A. Nemenoff Karen S. Moulton, Mark W. Majesky, and Mary C.M. Weiser-Evans (2023) The chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and in situ vascular fibrosis. JCI Insight, March 28:e164862. PMC10243795
  • Okamura DM, Nguyen ED, Collins SJ, Yoon K, Gere JB, Weiser-Evans MCM, Beier DR, Majesky MW. (2023) Mammalian organ regeneration in spiny mice. Special issue: Comparative & Extreme Physiology. J Muscle Res Cell Motility, Jun;44(2):39-52. PMID: 36131170 (PMCID currently pending)
  • Kayo Okamura, Sizhao Lu, Zhibin He, Chris Altmann, John Montford, Amy Li, M. Scott Lucia, David Orlicky, Mary Weiser-Evans, Sarah Faubel (2023) "L-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically-defined murine model. AJP-Renal Physiology, Sep 1;325(3):F328-F344.
  • Majesky MW, Weiser-Evans MCM. (2022) The adventitia in hypertension. Special issue: Emerging mechanisms in the pathogenesis of hypertension. Biochem Pharmacol, 205:115259. PMID: 36150432
  • Emily K. Kleczko, Trista K. Hinz, Teresa T. Nguyen, Natalia J. Gurule, Andre Navarro, Anh T. Le, Amber M. Johnson, Jeff Kwak, Diana I. Polhac, Eric T. Clambey, Mary Weiser-Evans, Daniel T. Merrick, Michael C. Yang, Tejas Patil, Erin L. Schenk, Lynn E. Heasley, Raphael A. Nemenoff (2023) Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity. Nat Precision Oncology, 7(1):15. PMC9899278
  • Emily K Kleczko, Anh T Le, Trista K Hinz, Teresa T Nguyen, Andre Navarro, Cheng-Jun Hu, Ana M. Selman, Eric T Clambey, Daniel T Merrick4, Sizhao Lu, Mary Weiser-Evans, Raphael A Nemenoff, Lynn E Heasley (2023) Novel EGFR-Mutant Mouse Models of Lung Adenocarcinoma Reveal Adaptive Immunity Requirement for Durable Osimertinib Response. Cancer Letters, Mar 1;556:216062.
  • Emily K. Kleczko, Joanna M. Poczobutt, Andre C. Navarro, Jennifer Laskowski, Amber M. Johnson, Sean P. Korpela, Natalia J. Gurule, Lynn E. Heasley, Katharina Hopp, Mary C.M. Weiser-Evans, Elizabeth B. Gottlin, Ryan T. Bushey, Michael J. Campa, Edward F. Patz Jr., Joshua M. Thurman, and Raphael A. Nemenoff (2023) Upregulation of complement proteins in lung cancer cells mediates tumor progression. Frontiers in Oncology, in press. PMC9849673
  • Calen A Steiner, Samuel D Koch, Tamara Evanoff, Nichole Welch, Rachael Kostelecky, Rosemary Callahan, Emily M Murphy, Caroline H T Hall, Sizhao Lu, Mary CM Weiser-Evans, Ian M Cartwright, Sean P Colgan (2023) The TNFdARE mouse as a model of intestinal fibrosis. Am J Pathol, May 9:S0002-9440(23)00166-9. (PMCID currently pending)
  • Benjamin McNair, Sydney Polson, Samantha Shorthill, Aykhan Yusifov, Lori Walker, Mary Weiser-Evans, Elizabeth Kovacs, and Danielle Bruns (2023) Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK. American Journal of Physiology-Heart and Circulatory Physiology, Aug 1;325(2):H278-H292. (PMCID currently pending)
  • Allison M Dubner, Sizhao Lu, Austin J Jolly, Tysen Noble, Tyler Hinthorn, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary CM Weiser-Evans (2023) Confounding effects of tamoxifen: Cautionary and practical considerations for the use of tamoxifen-inducible mouse models in atherosclerosis research. Arterioscler Thromb Vasc Biol, Nov;43(11):2223-2230. PMC10615862
  • Allison M Dubner, Sizhao Lu, Austin J Jolly, Keith A Strand, Marie F Mutryn, Tyler Hinthorn, Tysen Noble, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary CM Weiser-Evans (2023) Smooth muscle-derived adventitial progenitor cells promote key cell type transitions controlling plaque stability in atherosclerosis in a Klf4-dependent manner. JCI Insight, Nov 22;8(22):e174639.
  • Valentina d’Escamard, Daniella Kadian-dodov, Lijiang Ma, Shouneng Peng, Annette King, Allison Thomas, Bhargravi Vonguru, Yang Xu, Katherine C. Michelis, Emir Bander, Rihab Bouchareb, Adrien Georges, Aya Nomura-Kitabayashi, Yu Zhou, Elena Chepurko, Vadim, Chepurko, Marika Fava, Temo Barwan, Anelechi Anyanwu, Farzan Filsoufi, Sander Florman, Nabila Bouatia-Naji, Manuel Mayr, Michael G. Katz, Ke Hao, Johan LM Björkegren, Sizhao Lu, Mary CM Weiser-Evans, Jeffrey Olin, Jason Kovacic (2023) Integrative Gene Regulatory Network Analysis Discloses Key Driver Genes of Fibromuscular Dysplasia in Females: the DEFINE-FMD study. Nature Cardiovasc Research, under review after revision.
  • PMC8742724
  • PMID: 35331421
  • PMID: 35512358
  • PMID: 35512358
  • PMID: 36131170
  • PMID: 36150432
  • PMC9074982
  • PMC8464501
  • PMC8410116
  • PMC8562886
  • Amber M. Johnson, Jennifer M. Boland, Julia Wrobel, Mary C.M. Weiser-Evans, Emily K. Klezcko, Eric T. Clambey, Raphael A. Nemenoff, and Erin L. Schenk (2021) Cancer cell-specific major histocompatibility complex II expression as a determinant of the immune infiltrate organization and function in the NSCLC tumor microenvironment. Journal of Thoracic Oncology, in press.
  • Austin J. Jolly, Sizhao Lu, Keith A. Strand, Allison M. Dubner, Marie F. Mutryn, Raphael A. Nemenoff, Mark W. Majesky, Karen S. Moulton, and Mary C.M. Weiser-Evans (2021) Heterogeneous Subpopulations of Adventitial Progenitor Cells Regulate Vascular Homeostasis and Pathological Vascular Remodeling. Cardiovascular Research, in press.
  • Bradley S. Ferguson, Sara A. Wennersten, Kimberly M. Demos-Davies, Maria A. Cavasin, Matthew S. Stratton, Tianjing Hu, Marcello Rubino, Stephen M. Keyse, Robert A. McKnight, Robert H. Lane, Eva Nozik-Grayck, Mary C. M. Weiser-Evans, and Timothy A. McKinsey (2021) A DUSP5-Dependent Feedback Loop Controls Smooth Muscle Proliferation, Pulmonary Hypertension and Right Ventricular Hypertrophy. Am Journal Phys – Heart Circulatory Phys, in press.
  • Amrut V. Ambardekar, MD; Matthew S. Stratton, PhD; Evgenia Dobrinskikh, PhD; Kendall S. Hunter, PhD; Philip D. Tatman; Madeleine E. Lemieux, PhD; Joseph C. Cleveland, MD; Rubin M. Tuder, MD; Mary C.M. Weiser-Evans, PhD; Karen S. Moulton, MD; Timothy A. McKinsey, PhD. (2021) Continuous-Flow LVADs Downregulate Matrix-Degrading Enzyme Expression and Promote Fibrosis in the Human Aorta. J Am Col Cardiology, in press.
  • John Montford, Colin Bauer, Jeremy Rahkola, Julie Reisz, Katharina Hopp, Danielle Soranno, Jelena Klawitter, Mary Weiser-Evans, Raphael Nemenoff, Sarah Faubel, and Seth Furgeson. (2021) 15-Lipoxygenase Worsens Renal Fibrosis, Inflammation, and Metabolism in a Murine Model of Ureteral Obstruction. Am J Physiology – Renal Physiology, in press.
  • Amrut V. Ambardekar, MD; Matthew S. Stratton, PhD; Mary C.M. Weiser-Evans, PhD; Karen S. Moulton, MD; Timothy A. McKinsey, PhD. (2022) Aortic Valve Remodeling in CF-LVAD: Beyond the Arterial Wall. J Am Col Cardiology, in press.
  • Amrut V. Ambardekar, MD; Matthew S. Stratton, PhD; Mary C.M. Weiser-Evans, PhD; Karen S. Moulton, MD; Timothy A. McKinsey, PhD (2022) Reply: Aortic valve remodeling in CF-LVAD: Beyond the arterial wall. Journal Am Col Cardiology, in press.
  • AM Johnson, BL Bullock, A Neuwelt, J Poczobutt, HY Li, JW Kwak, MCM Weiser-Evans, ET Clamby, RA Nemenoff (2019) MHCII Expression on Lung Cancer Cells Mediates the Response to anti-PD-1 through Direct Interaction with CD4+ T Cells. Clinical Cancer Research, in press.
  • S Lu, MCM Weiser-Evans (2019) Nuclear focal adhesion kinase: Novel endogenous antagonist of focal adhesion kinase-mediated smooth muscle proliferation and neointima formation. Circulation Research, 125(2):167-169.
  • Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-induced Pathological Vascular Fibrosis and Remodeling-Brief Report. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):394-403.
  • Strand KA, Lu S, Mutryn MF, Li L, Zhou Q, Enyart BT, Jolly AJ, Dubner AM, Moulton KS, Nemenoff RA, Koch KA, LaBarbera DV, Weiser-Evans MCM. High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1854-1869.
  • S Lu, A Jolly, K Strand, AM Dubner, MF Mutryn, K.S. Moulton, R.A. Nemenoff, M.W. Majesky, MCM Weiser-Evans (2020) Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis. J Clinical Investigation Insight, 5(23):e139445
  • Wu W, Wang C, Zang H, Qi L, Azhar M, Nagarkatti M, Nagarkatti P, Cai G, Weiser-Evans MCM, Cui T. Mature Vascular Smooth Muscle Cells, but Not Endothelial Cells, Serve as the Major Cellular Source of Intimal Hyperplasia in Vein Grafts. Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1870-1890.
  • AM Johnson, BL Bullock, A Neuwelt, J Poczobutt, RE Kaspar, HY Li, JW Kwak, K Hopp, MCM Weiser-Evans, LE Heasley, EL Shenk, ET Clamby, RA Nemenoff (2020) Cancer cell-intrinsic expression of MHC class II regulates the immune microenvironment and response to anti-PD-1 therapy in lung adenocarcinoma. J Immunology, 204(8):2295-2307.
  • TR Sippel, AM Johnson, HY Li, D Hanson, TT Nguyen, BL Bullock, JM Poczobutt, JW Kwak, E Kleczko, MCM Weiser-Evans, RA Nemenoff (2019) Activation of PPAR? in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGF- ß1. Molecular Cancer Research, 17(8):1748-1758.
  • SJ Holditch, CN Brown, DJ Atwood, D Pokhrel, SE Brown, AM Lombardi, KN Nguyen, RC Hill, M Lanaspa, K Hopp, MCM Weiser-Evans, CL Edelstein (2019) The consequences of increased 4E-BP1 in polycystic kidney disease. Human Molecular Genetics, 28(24):4132-4147.
  • CN Brown, DJ Atwood, D Pokhrel, K Ravichandran, SJ Holditch, S Saxena, M Miyazaki, RA Nemenoff, MCM Weiser-Evans, DG Ljubanovic, MS Joy, CL Edelstein (2020) The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice. Cell Signal, 71:109605.
  • Dylewski JF, Wilson N, Lu S, Jat P, Weiser-Evans M, Panzer SE, Blaine J. Isolation, Purification, and Conditional Immortalization of murine Glomerular Endothelial Cells of microvascular phenotype. MethodsX. 2020:101048.
  • TR Sippel, AM Johnson, HY Li, D Hanson, TT Nguyen, BL Bullock, JM Poczobutt, JW Kwak, E Kleczko, MCM Weiser-Evans, RA Nemenoff (2019) Activation of PPAR? in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGF- ß1. Molecular Cancer Research, 2019; 17(8):1748-1758.
  • S Lu, MCM Weiser-Evans (2019) Nuclear focal adhesion kinase: Novel endogenous antagonist of focal adhesion kinase-mediated smooth muscle proliferation and neointima formation. Circulation Research, 125(2):167-169.
  • SJ Holditch, CN Brown, DJ Atwood, SE Brown, AM Lombardi, KN Nguyen, K Hopp, MCM Weiser-Evans, M Lanaspa, CL Edelstein (2019) The role of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) in polycystic kidney disease (PKD). Human Molecular Genetics, in press.
  • S Lu, K Strand, M Mutryn, R Tucker, M Cavasin, S Furgeson, RA Nemenoff, and MCM Weiser-Evans (2019) PTEN protects against Angiotensin II-induced pathological cardiovascular fibrosis and remodeling. ATVB, 40(2):394-403.
  • J Montford, C Bauer, E Dobrinskikh, K Hopp, M Levi, MCM Weiser-Evans, R Nemenoff, S Furgeson (2019) Inhibition of 5-Lipoxygenase Decreases Renal Fibrosis and Progression of Chronic Kidney Disease. American Journal of Physiology – Renal Physiology, 316:F732-F742. PMC6483031
  • BL Bullock, AK Kimball, J Poczobutt, HY Li, JW Kwak, A Neuwelt, AM Johnson, MCM Weiser-Evans, ET Clamby, RA Nemenoff (2019) Tumor-Intrinsic Response to IFN? Shapes the Tumor Microenvironment and Anti-PD-1 Response in NSCLC. Life Science Alliance, 2(3). PMC6537751
  • KS Moulton, M Li, K Strand, Shawna Burgett, P Mcclatchey, R Tucker, S Furgeson, S Lu, RA Nemnoff, A Ambardekar, MCM Weiser-Evans (2018) PTEN deficiency promotes pathological vascular remodeling of human coronary arteries. In press, J Clinical Investigation Insight.
  • AV Ambardekar, MCM Weiser-Evans, M Li, SN Purohit, M Aftab, TB Reece, KS Moulton (2018) Coronary artery remodeling and fibrosis is associated with continuous-flow left ventricular assist device support. Circulation: Heart Failure, in press.
  • H Li, D Walker, T Sippel, J Poczobutt, D Hanson, M Gijon, R Keith, MCM Weiser-Evans, and RA Nemenoff (2017) Targeted overexpression of prostacyclin synthase inhibits lung cancer progression and metastasis. In press, OncoImmunology.
  • K Ravichandran, Q Wang, A Ozkok, MCM Weiser-Evans, RA Nemenoff, H Thiessen-Philbrook, C Parikh, D Ljubanovic, and CL Edelstein (2018) IL-33 knockout slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer. In press, Amer J Physiol - Renal Physiology.
  • JW Kwak, J Laskowski, H Li, M McSharry, T Sippel, B Bullock, J Poczobutt, S Malkoski, MCM Weiser-Evans, E Clamby, J Thurman, and RA Nemenoff (2018) Complement activation mediates lung cancer progression and metastasis through alterations in infiltrating T lymphocytes. Cancer Research, 78:143-156.
  • JR Montford, AMB Lehman, CD Bauer, J Klawitter, J Klawitter, JM Poczobutt, M Scobey, MCM Weiser-Evans, RA Nemenoff, SB Furgeson (2018) Bone marrow-derived cPLA2a contributes to renal fibrosis progression. J Lipid Res, in press.
  • K Ravichandran, Q Wang, A Ozkok, MCM Weiser-Evans, RA Nemenoff, H Thiessen-Philbrook, C Parikh, D Ljubanovic, and CL Edelstein (2018) IL-33 knockout slows cancer growth but does not protect against cisplatin-induced AKI in mice with cancer. Amer J Physiol – Renal Physiology, 314(3):F356-F366.
  • JW Kwak, J Laskowski, H Li, M McSharry, T Sippel, B Bullock, J Poczobutt, S Malkoski, MCM Weiser-Evans, E Clamby, J Thurman, and RA Nemenoff (2018) Complement activation mediates lung cancer progression and metastasis through alterations in infiltrating T lymphocytes. Cancer Research, 78(1):143-156.
  • JR Montford, AMB Lehman, CD Bauer, J Klawitter, J Klawitter, JM Poczobutt, M Scobey, MCM Weiser-Evans, RA Nemenoff, SB Furgeson (2018) Bone marrow-derived cPLA2a contributes to renal fibrosis progression. J Lipid Res, 59(2):380-390.
  • KS Moulton, M Li, K Strand, S Burgett, P Mcclatchey, R Tucker, S Furgeson, S Lu, B Kirkpatrick, JC Cleveland, RA Nemenoff, A Ambardekar, MCM Weiser-Evans (2018) PTEN deficiency promotes pathological vascular remodeling of human coronary arteries. J Clinical Investigation Insight, Feb. 22; 3(4).
  • AV Ambardekar, MCM Weiser-Evans, M Li, SN Purohit, M Aftab, B Reece, KS Moulton (2018) Coronary artery remodeling and fibrosis with continuous-flow left ventricular assist device support. Circulation Heart Failure, 11(5):e004491.
  • E Kleczko, K Marsh, L Tyler, S Furgeson, B Bullock, C Altman, M Miyazaki, PC Harris, MCM Weiser-Evans, M Chonchol, E Clambey, RA Nemenoff, K Hopp (2018) CD8+ T-cells modulate autosomal dominant polycycstic kidney disease progression. Kidney International, 94(6):1127-1140.
  • Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II. Li HY, McSharry M, Walker D, Johnson A, Kwak J, Bullock B, Neuwelt A, Poczobutt JM, Sippel TR, Keith RL, Weiser-Evans MCM, Clambey E, Nemenoff RA. Oncoimmunology. 2018 Feb 13;7(5):e1423182
  • HY Li, M McSharry, TT Nguyen, J Kwak, JM Poczobutt, B Bullock, TR Sippel, N Little, J DeGregori, MCM Weiser-Evans, ET Clambey, and RA Nemenoff (2017) The tumor microenvironment regulates sensitivity of murine lung tumors to PD-1/PD-L1 antibody blockade. Cancer Immunology Research, 5(9):767-777.
  • MW Majesky, H Horita, A Ostriker, JN Regan, XR Dong, J Poczobutt, RA Nemenoff, and MCM Weiser-Evans (2017) Differentiated smooth muscle cells generate a subpopulation of resident vascular progenitor cells in the adventitia regulated by Klf4. Circulation Research, 120:296-311. PMC5250562
  • MCM Weiser-Evans (2017) Smooth muscle differentiation control comes full circle: the circular non-coding RNA, circActa2, functions as a miRNA sponge to "fine-tune" SMA expression. Circulation Research, 121(6):591-593. PMC5679083
  • Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA. Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. J Immunol. 2016 Jan 15;196(2):891-901. PubMed PMID: 26663781
  • JM Poczobutt, S De, VK Yadav, TT Nguyen, H Li, T Sippel, MCM Weiser-Evans, RA Nemenoff. Expression profiling of macrophages reveals multiple populations with distinct biological roles in an immunocompetent orthotopic model of lung cancer. J Immunology, 2016, in press.
  • H Horita, CL Wysoczynski, LA Walker, KS Moulton, M Li, A Ostriker, R Tucker, TA McKinsey, MEA Churchill, RA Nemenoff, and MCM Weiser-Evans (2016) Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nature Communications, 7:10830.
  • MW Majesky, H Horita, A Ostriker, JN Regan, XR Dong, J Poczobutt, RA Nemenoff, and MCM Weiser-Evans (2017) Differentiated smooth muscle cells generate a subpopulation of resident vascular progenitor cells in the adventitia regulated by Klf4. Circulation Research, 120:296-311. *Circulation Research Editorial of this manuscript and Cover Figure
  • J Poczobutt, D Hanson, T Nguyen, H Li, T Sippel, MCM Weiser-Evans, and RA Nemenoff (2016) Deletion of 5-Lipoxygenase in the tumor microenvironment promotes lung cancer progression and metastasis in an orthotopic immunocompetent mouse model. J Immunology, 196(2):891-901. PMC4705594
  • K Ravichandran, Q Wang, A Ozkok, A Jani, H Li, Z He, D Ljubanovic, MCM Weiser-Evans, RA Nemenoff, and CL Edelstein (2016) CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med, 94(4):443-55.
  • JM Poczobutt, S De, VK Yadav, TT Nguyen, H Li, T Sippel, MCM Weiser-Evans, RA Nemenoff (2016) Expression profiling of macrophages reveals multiple populations with distinct biological roles in an immunocompetent orthotopic model of lung cancer. J Immunology, 196(6):2847-59.
  • JR Montford, A Lehman, MCM Weiser-Evans, RA Nemenoff, SB Furgeson (2016) Expression of cytosolic phospholipase A2 regulates the phenotype of renal tubular epithelial cells. In press, Prostaglandins and Other Lipid Mediators.
  • Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z, Ljubanovic D, Weiser-Evans MC, Nemenoff RA, Edelstein CL. CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2015 Dec 1. [Epub ahead of print] PubMed PMID: 26620676
  • Roe ND, Xu X, Kandadi MR, Hu N, Pang J, Weiser-Evans MC, Ren J. Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Biochim Biophys Acta. 2015 Feb;1852(2):290-8. PubMed PMID: 25229693
  • ND Roe, MR Kandadi, MCM Weiser-Evans, J Ren (2015) Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Biochim Biophys Acta. 2015 Feb;1852(2):290-8.
  • X Xu, ND Roe, MCM Weiser-Evans, J Ren (2014) Inhibition of mTOR with rapamycin reverses hypertrophic cardiomyopathy in mice with cardiomyocytes-specific knockout of PTEN. In press, Hypertension.
  • A Ostriker, HN Horita, J Poczobutt, MCM Weiser-Evans*, RA Nemenoff* (2014) Vascular Smooth Muscle Cell-derived TGF-b Promotes Maturation of Neointima-Associated Macrophages, in press, ATVB. *Equal Corresponding Authors; funded by Weiser-Evans R01.
  • LA Marek, TK Hinz, A von Massenhausen, KA Olszewski, E Kleczko, D Bohm, MCM Weiser-Evans, RA Nemenoff, JM Gozgit, S Perner, and LE Heasley (2014) Non-Amplified FGFR1 is a Growth Driver in Malignant Pleural Mesothelioma Cells. Under review, Molecular Cancer Therapeutics.
  • A Lehman, J Montford, H Horita, A Ostriker, MCM Weiser-Evans, RA Nemenoff, and SB Furgeson (2014) Activation of the retinoid X receptor modulates Angiotensin II-induced smooth muscle gene expression and inflammation. Under review, Mol Pharm.
  • H Horita, A Ostriker, CL Mattivi, D Hanson, RA Nemenoff, MW Majesky, and MCM Weiser-Evans (2013) In vivo reprogramming of mature differentiated smooth muscle cells gives rise to a distinct subpopulation of resident vascular progenitor cells. in final preparation, Circ Res..
  • ND Roe, MR Kandadi, MCM Weiser-Evans, J Ren (2014) Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Under review.
  • X Xu, ND Roe, MCM Weiser-Evans, J Ren (2014) Inhibition of mTOR with rapamycin reverses hypertrophic cardiomyopathy in mice with cardiomyocytes-specific knockout of PTEN. Hypertension, 63(4):729-39. PMC Journal in process
  • A Ostriker, HN Horita, J Poczobutt, MCM Weiser-Evans*, RA Nemenoff* (2014) Vascular Smooth Muscle Cell-derived TGF-b Promotes Maturation of Neointima-Associated Macrophages, ATVB, 34(4):877-86. PMC3966963
  • LA Marek, TK Hinz, A von Massenhausen, KA Olszewski, E Kleczko, D Bohm, MCM Weiser-Evans, RA Nemenoff, Hoffmann H, Warth A, JM Gozgit, S Perner, and LE Heasley (2014) Non-Amplified FGFR1 is a Growth Driver in Malignant Pleural Mesothelioma. Molecular Cancer Res, 2014 Oct;12(10):1460-9.
  • A Lehman, J Montford, H Horita, A Ostriker, MCM Weiser-Evans, RA Nemenoff, and SB Furgeson (2014) Activation of the retinoid X receptor modulates Angiotensin II-induced smooth muscle gene expression and inflammation. Mol Pharm. 2014 Nov;86(5):570-9.
  • H Horita, SB Furgeson, A Ostriker, KA Olszewski, T Sullivan, LR Villegas, M Levine, JE Parr, CD Cool, RA Nemenoff, and MCM Weiser-Evans (2013) Inactivation of PTEN Selectively in Smooth Muscle Cells Synergizes with Hypoxia to Induce Severe Pulmonary Arterial Hypertension. JAHA, 31;2(3):e000188.
  • Nguyen Anh, Delphine Gomez, Robert D Bell, Julie H Campbell, Alexander W Clowes, Giulio Gabbiani, Cecilia M Giachelli, Michael S Parmacek, Elaine W Raines, Nancy J Rusch, Mei Y Speer, Michael Sturek, Johan Thyberg, Dwight A Towler, Mary CM Weiser-Evans, Chen Yan, Joseph M Miano, Gary K Owens (2013) Smooth Muscle Cell Plasticity: Fact or Fiction? Circ Res, 4;112(1):17-22.
  • J Poczobutt, M Gijon, J Amin, D Hanson, H Li, D Walker, D Merrick, M Lewis, W Franklin, M Chan, MCM Weiser-Evans, X Lu, MG Edwards, R Murphy, and RA Nemenoff (2013) Eicosanoid Profiling in Lung Cancer by Mass Spectrometry Demonstrates Selective Production of Leukotrienes by Cells of the Microenvironment. Plos One, Nov 11;8(11):e79633.
  • H Horita, KA Olszewski, A Ostriker, CL Mattivi, V Van Putten, RA Nemenoff, MW Majesky, and MCM Weiser-Evans (2012) Microenvironmental reprogramming of differentiated smooth muscle cells gives rise to resident vascular progenitor cells. In preparation for submission, Circ Res.
  • H Horita, A Ostriker, KA Olszewski, CL Mattivi, V Van Putten, RA Nemenoff, and MCM Weiser-Evans (2012) Nuclear PTEN interacts with and selectively regulates SRF-dependent smooth muscle gene expression. In preparation for submission, PNAS.
  • SB Furgeson, A Lehman, V Van Putten, H Horita, A Ostriker, *MCM Weiser-Evans, and *RA Nemenoff (2012) Activation of the retinoid X receptor modulates Angiotensin II-induced smooth muscle gene expression and inflammation. In preparation for submission, JBC. *Equal Senior Authors
  • H Horita, SB Furgeson, A Ostriker, KA Olszewski, T Sullivan, LR Villegas, M Levine, JE Parr, CD Cool, RA Nemenoff, and MCM Weiser-Evans (2013) Inactivation of PTEN Selectively in Smooth Muscle Cells Synergizes with Hypoxia to Induce Severe Pulmonary Arterial Hypertension. Under revision, JAHA.
  • Nguyen Anh, Delphine Gomez, Robert D Bell, Julie H Campbell, Alexander W Clowes, Giulio Gabbiani, Cecilia M Giachelli, Michael S Parmacek, Elaine W Raines, Nancy J Rusch, Mei Y Speer, Michael Sturek, Johan Thyberg, Dwight A Towler, Mary CM Weiser-Evans, Chen Yan, Joseph M Miano, Gary K Owens (2012) Smooth Muscle Cell Plasticity: Fact or Fiction? In press, Circ Res.
  • MA Cavasin, K Demos-Davies, TR Horn, LA Walker, DD Lemon, N Birdsey, MCM Weiser-Evans, J Harral, DC Irwin, A Anwar, ME Yeager, M Li, PA Watson, RA Nemenoff, PM Buttrick, KR Stenmark, and TA McKinsey (2012) Selective class I HDAC inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an anti-proliferative mechanism. Circ Res, in press.
  • H Li, MCM Weiser-Evans, RA Nemenoff (2011) Biological role and signaling pathways of PPAR? in lung cancer. Invited review, PPAR Research, submitted.
  • J Melonakos, T McCord, M Atmakuri, M Padgett, T Becker, M Weiser-Evans, D Bowles, T Schroeder, M Dewhirst, and C Kontos. The Tumor Suppressor PTEN Is Required for the Cellular Response to Hypoxia. (2012) under review after revision, J Biol Chem.
  • MA Cavasin, K Demos-Davies, TR Horn, LA Walker, DD Lemon, N Birdsey, MCM Weiser-Evans, J Harral, DC Irwin, A Anwar, ME Yeager, M Li, PA Watson, RA Nemenoff, PM Buttrick, KR Stenmark, and TA McKinsey (2012) Selective class I HDAC inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an anti-proliferative mechanism. Circ Res, 110(5):739-48. PMC Journal in process
  • H Li, MCM Weiser-Evans, RA Nemenoff (2012) Anti- and Pro-tumorigenic Effects of PPAR? in Lung Cancer Progression: A Double-Edged Sword. PPAR Research, Volume 2012 (2012), Article ID 362085.
  • SM Majka, HL Miller, T Sullivan, PF Erickson, R Kong, MCM Weiser-Evans, RA Nemenoff, R Moldovan, SA Morandi, JA Davis, DJ Klemm (2012) Adipose lineage specification of bone marrow-derived myeloid cells. Adipocyte, in press.
  • RA Nemenoff, H Horita, AC Ostriker, SB Furgeson, PA Simpson, V Van Putten, JT Crossno, S Offermanns, and MCM Weiser-Evans (2011) SDF-1a Induction in Mature Smooth Muscle Cells by Inactivation of PTEN is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation. ATVB Jun;31(6):1300-8. PMCID: PMC3111081
  • H Li, A Sorenson, J Poczobutt, D Middleton, J Amin, T Sullivan, JT Crossno Jr, MCM Weiser-Evans*, RA Nemenoff* (2011) Activation of PPAR? in myeloid cells promotes lung cancer progression and metastasis. Plos One, 2011;6(12):e28133. *Equal Corresponding Authors PMCID: PMC3228753
  • H Horita, P Simpson, A Ostriker, S Furgeson, V vanPutten, MCM Weiser-Evans*, and RA Nemenoff* (2011) Serum response factor regulates expression of PTEN through a micro-RNA network in vascular smooth muscle cells. ATVB, 31:2909-19. *Equal Corresponding Authors PMCID: PMC3220738H Horita, P Simpson, A Ostriker, S Furgeson, V vanPutten, MCM Weiser-Evans*, and RA Nemenoff* (2011) Serum response factor regulates expression of PTEN through a micro-RNA network in vascular smooth muscle cells. ATVB, 31:2909-19. *Equal Corresponding Authors PMCID: PMC3220738
  • A Andres-Hernando, C Altmann, N Ahuja, M Lanaspa, R Nemenoff, Z He, T Ishimoto, P Simpson, MCM Weiser-Evans, J Bacalja, and S Faubel (2011) Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice. AJP-Renal Physiology, Oct;301(4):F907-16. PMCID: PMC3191803
  • SDF-1a Induction in Mature Smooth Muscle Cells by Inactivation of PTEN is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation
  • The Transcription Factor, SRF, Regulates PTEN Expression in Vascular Smooth Muscle Cells Through miR-143-Mediated Repression of miR-21
  • SB Furgeson, PA Simpson, I Park, V VanPutten, RA Nemenoff, and MCM Weiser-Evans (2010) Heterozygous Disruption of PTEN in Smooth Muscle Promotes a Pro-inflammatory Phenotype and Enhances Neointima Formation. Cardiovascular Res, in press.
  • M Tennis, M Van Scoyk, LE Heasley, K Vandervest, MCM Weiser-Evans, S Freeman, RL Keith, P Simpson, RA Nemenoff, and RA Winn (2010) Prostacyclin inhibits non small cell lung cancer growth by a frizzled 9 dependent pathway that is blocked by secreted frizzled related protein-1. Neoplasia, in press.
  • R Choudhary, H Li, MCM Weiser-Evans, and RA Nemenoff (2010) PPAR? Inhibits Transformed Growth of Non-Small Cell Lung Cancer Cells Through Selective Suppression of Snail. Neoplasia, in press.
  • Nemenoff, Simpson, Horita, Park, Furgeson,Van Putten, Sullivan, Crossno, and Weiser-Evans (2010) Inducible deletion of PTEN selectively in smooth muscle accelerates neointima formation through upregulation of SDF-1alpha, in preparation.
  • Weiser-Evans, Li, Sorenson, Simpson, Crossno, and Nemenoff (2010) Systemically delivered pioglitazone accelerates lung cancer metastasis by promoting an M2 macrophage phenotype and enhancing angiogenesis, in preparation.
  • SB Furgeson, PA Simpson, I Park, V VanPutten, RA Nemenoff, and MCM Weiser-Evans (2010) Heterozygous Disruption of PTEN in Smooth Muscle Promotes a Pro-inflammatory Phenotype and Enhances Neointima Formation. Cardiovascular Res, May 1;86(2):274-82.
  • M Tennis, M Van Scoyk, LE Heasley, K Vandervest, MCM Weiser-Evans, S Freeman, RL Keith, P Simpson, RA Nemenoff, and RA Winn (2010) Prostacyclin inhibits non small cell lung cancer growth by a frizzled 9 dependent pathway that is blocked by secreted frizzled related protein-1. Neoplasia, Mar;12:244-53.
  • R Choudhary, H Li, MCM Weiser-Evans, and RA Nemenoff (2010) PPAR? Inhibits Transformed Growth of Non-Small Cell Lung Cancer Cells Through Selective Suppression of Snail. Neoplasia, Mar;12(3):224-34.
  • MCM Weiser-Evans, AM Meyer, XQ Wang, R Choudhary, J Amin, V Van Putten and RA Nemenoff (2009) Cytosolic phospholipase A2 in the lung tumor microenvironment is critical for tumor progression and metastasis. Cancer Research, in press.
  • SB Furgeson, PA Simpson, V VanPutten, RA Nemenoff, and MCM Weiser-Evans (2009) Smooth muscle-specific deletion of PTEN promotes phenotypic modulation, inflammatory cytokine production, and enhances neointima formation following vascular injury. ATVB, in revision.
  • RA Nemenoff, M Van Scoyk, LE Heasley, K Rodriquez, MCM Weiser-Evans, LM Williams, JA Randall, RL Keith, M Tennis, RA Winn. Prostacyclin and its synthetic analog Iloprost reverse transformed cell growth by a frizzled 9 dependent pathway in non small cell lung cancer. Submitted with revisions.
  • MCM Weiser-Evans, XQ Wang, R Choudhary, J Amin, V Van Putten and RA Nemenoff (2009) Cytosolic phospholipase A2 in the lung tumor microenvironment is critical for tumor progression and metastasis. Cancer Research, 69(5):1733-8. PMC2653105
  • RA Nemenoff , P Simpson , S Furgeson , N Kaplan-Albuquerque , J Crossno , P Garl , J Cooper , and MCM Weiser-Evans (2008) Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of SDF-1a. Circulation Research, in press.
  • Y Bren-Mattison1, AM Meyer1, V Van Putten, H Li, K Kuhn, R Stearman, MCM Weiser-Evans, RA Winn, LE Heasley, and RA Nemenoff (2007) Antitumorigenic effects of Peroxisome Proliferator-Activated receptor-? (PPAR-?) in Non-small Cell Lung Cancer Cells (NSCLC) are mediated by suppression of COX-2 via inhibition of NF-kB. Molecular Pharmacology, in press
  • A Role for cytosolic phosholipase A2 in the tumor microenvironment shown in a xenograft model of lung tumor growth and metastasis Amy M. Meyer, Nihal Kaplan-Albuquerque Xue-Qing Wang, Mary Weiser-Evans, and Raphael A. Nemenoff
  • Smooth muscle PTEN depletion promotes neointima formation and increased chemokine production. Seth Furgeson, Pete Simpson, Nihal Kaplan-Albuquerque, James Cooper, Raphael Nemenoff, Mary Weiser-Evans.
  • RA Nemenoff , P Simpson , S Furgeson , N Kaplan-Albuquerque , J Crossno , P Garl , J Cooper, and MCM Weiser-Evans (2008) Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of SDF-1a. Circulation Research 102:1036-1045
  • RA Nemenoff, MCM Weiser-Evans, and RA Winn (2008) Activation and Molecular targets of peroxisome proliferators-activated receptor-? ligands in lung cancer. PPAR Research, 2008:156875.
  • RA Nemenoff, AM Meyer, TM Hudish, AB Mozer, A Snee, S Narumiya, RS Stearman, RA Winn, MCM Weiser-Evans, MW Geraci, RL Keith (2008) Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of PPAR?. Cancer Prevention Research, Oct;1(5):349-56.
  • Antitumorigenic effects of peroxiisome proliferator-activated receptor-gamma in non-small cell lung cancer cells are mediated by suppression of Cox-2 via inhibition of NFkappaB. Y Bren-Mattison, A Meyer, V VanPutten, H Li, M Moore, A Snee, K Kuhn, R Stearman, M Weiser-Evans, R Winn, L Heasley R Nemenoff.
  • Seth B Furgeson, Peter A Simpson, Nihal Kaplan-Albuquerque, James Cooper, Raphael Nemenoff, Mary CM Weiser-Evans. PTEN depletion enhances vascular smooth muscle cell proliferation and accelerates neointima formation. Arteriosclerosi, Thrombosis, and Vascular Biology Annual Conference. *Dr. Furgeson won the ATVB Travel Award for Young Investigators
  • Perlecan/PTEN Signaling: Role in Smooth Muscle Quiescence. MCM Weiser-Evans Arteriosclerosi, Thrombosis, and Vascular Biology Annual Conference. Invited Speaker
  • Nemenoff RA, Simpson P,Furgeson S, Albuquerque-Kaplan N, Mak T, Garl PJ, Crossno J, Weiser-Evans MCM. Smooth muscle-specific inactivation of the tumor suppressor, PTEN, results in early postnatal lethality: role of cell autonomous signaling and circulating progenitor cells.
  • James Cooper Seth, Nihal Kaplan-Albuquerque, Mary CM Weiser-Evans, Raphael Nemenoff. Akt isoforms have Distinct Roles in Photypic Modulation of VSMC and During Vascular Injury. Arteriosclerosi, Thrombosis, and Vascular Biology Annual Conference.
  • Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Bruk-Artinger K, Nemenoff RA, Weiser-Evans MCM. Embryonic Growth Associated Protein is a Subunit of a Novel N-Terminal Acetyltransferase Complex Essential for Embryonic Vascular Development. Developmental Vascular Biology Workshop, Asilomar, CA, 2006.
  • Nemenoff RA, Albuquerque-Kaplan N, Boegart Y, Weiser-Evans MCM. Restricted inactivation of the tumor suppressor, PTEN, to the cardiovascular system results in early postnatal lethality. Developmental Vascular Biology Workshop, Asilomar, CA, 2006
  • Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Bruk-Artinger K, Nemenoff RA, Weiser-Evans MCM. Embryonic Growth Associated Protein is a Subunit of a Novel N-Terminal Acetyltransferase Complex Essential for Embryonic Vascular Development. UCHSC Research Day, 2005.
  • Nemenoff RA, Albuquerque-Kaplan N, Boegart Y, Weiser-Evans MCM. Restricted inactivation of the tumor suppressor, PTEN, to the cardiovascular system results in early postnatal lethality. UCHSC Research Day, 2005.
  • Nemenoff RA, Albuquerque-Kaplan N, Simpson P, Mak T, Weiser-Evans MCM. Cardiovascular-specific inactivation of the tumor suppressor, PTEN, results in early postnatal lethality: role of cell autonomous signaling and circulating progenitor cells. FASEB Summer Conference: Smooth Muscle, Snowmass, CO, 2006.
  • Seth B. Furgeson, Pete Simpson, Nihal Kaplan-Albuquerque, Raphael A. Nemenoff and Mary C.M. Weiser-Evans. THE ROLE OF PTEN IN NEOINTIMA FORMATION. UCHSC Research Day, 2006.
  • Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Bruk-Artinger K, Nemenoff RA, Weiser-Evans MCM. (2006) Embryonic Growth Associated Protein is a Subunit of a Novel N-Terminal Acetyltransferase Complex Essential for Embryonic Vascular Development. (in press Circulation Research). *Circulation Research Editorial of this manuscript
  • Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Bruk-Artinger K, Nemenoff RA, Weiser-Evans MCM. Embryonic Growth Associated Protein is a Subunit of a Novel N-Terminal Acetyltransferase Complex Essential for Embryonic Vascular Development. Developmental Vascular Biology Workshop, Asilomar, CA, 2006.
  • Nemenoff RA, Albuquerque-Kaplan N, Boegart Y, Weiser-Evans MCM. Restricted inactivation of the tumor suppressor, PTEN, to the cardiovascular system results in early postnatal lethality. Developmental Vascular Biology Workshop, Asilomar, CA, 2006
  • Nemenoff RA, Simpson P, Miano JM, Weiser-Evans MCM. Restricted inactivation of the tumor suppressor, PTEN, to the cardiovascular system results in early postnatal lethality (in preparation).
  • JM Wenzlau, PJ Garl, P Simpson, K Artinger, J West, RA Nemenoff, MCM Weiser-Evans. The EGAP N-terminal Acetyltransferase Complex is Essential for Embryonic
  • Kaplan-Albuquerque N, Van Putten V, Weiser-Evans MCM, and Nemenoff RA (2005) Depletion of SRF by RNA interference Mimics the Mitogenic Effects of PDGF-BB in Vascular Smooth Muscle Cells. Circ Res Sep 2;97(5):427-33. *Circulation Research Editorial of this manuscript
  • Kaplan-Albuquerque N, Bogaert YE, Van Putten V, Weiser-Evans MCM, and Raphael A. Nemenoff. (2005) Patterns of gene expression differentially regulated by PDGF and hypertrophic stimuli in vascular smooth muscle cells: markers for phenotypic modulation and response to injury. J Biol Chem. 280(20):19966-76.
  • Gerasismovskaya E, Tucker D, Weiser-Evans MCM, Wenzlau JM, Klemm D, Banks M, and Stenmark KR (2005) Extracellular ATP-induced proliferation of adventitial fibroblasts requires Phosphoinositide 3’-kinase, Akt, Mammalian Target of Rapamycin and p70S6 kinase signaling pathways. J Biol Chem 280(3):1838-48.
  • Kaplan-Albuquerque N, Bogaert YE, Van Putten V, Weiser-Evans MCM, and Raphael A. Nemenoff. Patterns of Gene Expression Mediated by PDGF-BB and its downstream effectors H-ras and Akt in Vascular Smooth Muscle Cells, Vascular Biology Gordon Conference 2005.
  • Whitelock JM, Chou NC, and Weiser-Evans MCM. Proteoglycans and vascular bioengineering. European Society for Biomaterials Annual Meeting 2005.
  • Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Bruk-Artinger K, Nemenoff RA, Weiser-Evans MCM. Embryonic Growth Associated Protein is a Subunit of a Novel N-Terminal Acetyltransferase Complex Essential for Embryonic Vascular Development. UCHSC Research Day, 2005.
  • Nemenoff RA, Albuquerque-Kaplan N, Boegart Y, Weiser-Evans MCM. Restricted inactivation of the tumor suppressor, PTEN, to the cardiovascular system results in early postnatal lethality. UCHSC Research Day, 2005.
  • J Melonakos, T McCord, M Atmakuri, M Padgett, T Becker, M Weiser-Evans, D Bowles, T Schroeder, M Dewhirst, and C Kontos. The Tumor Suppressor PTEN Is Required for the Cellular Response to Hypoxia. (2011) under revision, Cancer Research.
  • RA Nemenoff, H Horita, AC Ostriker, SB Furgeson, PA Simpson, V Van Putten, JT Crossno, S Offermanns, and MCM Weiser-Evans (2011) SDF-1a Induction in Mature Smooth Muscle Cells by Inactivation of PTEN is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation. Under Review, ATVB
  • H Li, A Sorenson, J Poczobutt, D Middleton, J Amin, T Sullivan, JT Crossno Jr, MCM Weiser-Evans*, RA Nemenoff* (2011) Pioglitazone Promotes Lung Cancer Growth and Metastasis in an Orthotopic Syngeneic Mouse Model. Under revision, Clinical Cancer Research. *Equal Senior Authors
  • H Horita, S Furgeson, P Simpson, RA Nemenoff*, and MCM Weiser-Evans* (2011) The Transcription Factor, SRF, Regulates PTEN Expression in Vascular Smooth Muscle Cells Through miR-143-Mediated Repression of miR-21. In preparation, ATVB. *Equal Senior Authors
  • Keith Strand, Sizhao Lu, Marie Mutryn, Linfeng Li, Qiong Zhou, Blake Enyart, Rebecca Tucker, Austin Jolly, Allison Dubner, Karen Moulton, Raphael Nemenoff, Keith Koch, Daniel Labarbera, Mary C.M. Weiser-Evans. High throughput screening identifies the DNMT1 inhibitor, 5-azacytidine, as a potent inducer of smooth muscle PTEN: a central role for PTEN elevation in mediating 5-azacytidine protection against pathological vascular remodeling, Circulation, 2010, under review
  • S Wang, L Yang, X Qin, A Mason, MCM Weiser-Evans, Y Zhang, J Ren (2019) MelQTTBatonin attenuates hypertrophic cardiomyopathy in a murine model of cardiomyocyte-specific knockout of PTEN: Role of AMPK-Skp2-SUV39H-Sirt1-mediated regulation of autophagy. Under review, J Pineal Research.
  • H Horita, A Ostriker, KA Olszewski, CL Mattivi, V Van Putten, RA Nemenoff, and MCM Weiser-Evans (2014) Nuclear PTEN functions as an essential transcriptional co-factor with SRF independent of its phosphatase activity to control smooth muscle differentiation. Under review, PNAS.
  • H Horita, A Ostriker, D Hanson, CL Mattivi, V Van Putten, RA Nemenoff, and MCM Weiser-Evans (2014) Nuclear PTEN functions as an essential transcriptional co-factor with SRF independent of its phosphatase activity to control smooth muscle differentiation. In revision, Nat Commun.
  • H Horita, A Ostriker, D Hanson, CL Mattivi, RA Nemenoff, MW Majesky, and MCM Weiser-Evans (2015) Klf4-dependent reprogramming of mature differentiated smooth muscle cells gives rise to a distinct subpopulation of resident vascular progenitor cells. Submitted, Develop Cell.
  • J Poczobutt, D Hanson, T Nguyen, H Li, T Sippel, MCM Weiser-Evans, and RA Nemenoff (2015) Deletion of 5-Lipoxygenase in the tumor microenvironment promotes lung cancer progression and metastasis in an orthotopic immunocompetent mouse model. In revisio, Neoplasia.
  • H Li, D. Walker, T Sippel, J Poczobutt, D Hanson, M Gijon, R Keith, MCM Weiser-Evans, and RA Nemenoff (2015) Targeted overexpression of prostacyclin synthase inhibits lung cancer progression and metastasis. In revision, Plos One.
  • K Ravichandran, H Kim, A Ozkok, Q Wang, A Jani, H Li, Z He, MCM Weiser-Evans, RA Nemenoff, and CL Edelstein (2015) CD4 T cell knockout is not sufficient to prevent cisplatin-induced AKI using a therapeutically relevant dose of cisplatin in mice with cancer. Under review.
  • PMID: 36657561

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  • North American Vascular Biology Organization, Member

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