David Barton, PhD

Publications

• Steil, B.P., B.J. Kempf and D.J. Barton. 2010. Poly(A) at the 3’ end of positive-strand RNA and VPg-linked poly(U) at the 5’ end of negative-strand RNA are reciprocal templates during replication of poliovirus RNA. J. Virol. 84:2843-2858
• Hobdey, S.E., B.J. Kempf, B.P. Steil, D.J. Barton, and O.B. Peersen. 2010. Poliovirus polymerase residue 5 plays a critical role in elongation complex stability. J. Virol. 84:8072-8084.
• Malathi, K., T. Saito, N. Crochet, D.J. Barton, M. Gale Jr., and R.H. Silverman. 2010. RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. RNA. 16:2108-2119.
• Barton, D.J., B.J. Kempf and B.P. Steil. 2010. Synthesis of 3’ poly(A) tails during poliovirus RNA replication. Ninth International Positive-Strand RNA Virus Symposium, Atlanta, GA, May 17th to 21st.
• Cooper DA, Jha BK, Silverman RH, Hesselberth JR, Barton DJ. Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs. Nucleic Acids Res. 2014 Feb 5. [Epub ahead of print] PubMed PMID: 24500209
• Kempf, B.J. and D.J. Barton. 2010. Naturally uncapped poliovirus mRNA stability in 2Aprotease-modified polysomes. Ninth International Positive-Strand RNA Virus Symposium, Atlanta, GA, May 17th to 21st.
• Kempf BJ, Kelly MM, Springer CL, Peersen OB, Barton DJ. Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA. J Virol. 2013 May;87(10):5629-44. PubMed PMID: 23468507
• Silverman, R.H., K. Malathi, T. Saito, N. Crochet, D.J. Barton, M. Gale. Jr. 2010. A cryptic RNA amplifies innate immunity to hepatitis C virus. Ninth International Positive-Strand RNA Virus Symposium, Atlanta, GA, May 17th to 21st.
• Hobdey, S.E., B. Steil, D. Barton, O.B. Peersen. 2010. Poliovirus polymerase residue 5 plays a critical role in elongation complex stability. American Society For Virology Annual Meeting, Montana State University, Bozeman, MT, July 17-21.
• Cooper D., A. Khromykh, S.M. Lemon, R.H. Silverman and D.J. Barton. 2011. Exploring the susceptibility of positive-strand RNA genomes to cleavage by RNase L. American Society For Virology Annual Meeting, University of Minnesota, Minneapolis, MN, July 16-20.
• Cooper DA, Jha BK, Silverman RH, Hesselberth JR, Barton DJ. Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs. Nucleic Acids Res. 2014 Apr;42(8):5202-16. PubMed PMID: 24500209
• Kempf, B.J., O.B. Peersen, and D.J. Barton. 2011. Features of poliovirus 3D polymerase that affect the length of 3’ poly(A) tails in viral RNA. American Society For Virology Annual Meeting, University of Minnesota, Minneapolis, MN, July 16-20.
• Cooper DA, Banerjee S, Chakrabarti A, García-Sastre A, Hesselberth JR, Silverman RH, Barton DJ. RNase L Targets Distinct Sites in Influenza A Virus RNAs. J Virol. 2015 Mar 1;89(5):2764-76. PubMed PMID: 25540362
• Shimikami, T., D. Yamane, R.K. Jangra, B.J. Kempf, C. Spaniel, D.J. Barton, S.M. Lemon. 2012. Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc. Natl. Acad. Sci. USA 109:941-946.
• Kortus, M.G., B.J. Kempf, K.G. Haworth, D.J. Barton, O.B. Peersen. 2012. A template RNA entry channel in the fingers domain of poliovirus polymerase. J. Mol. Biol. 417:263-278.
• Schuessler, A., A. Funk, H. Lazear, D.A. Cooper, S. Torres, S. Daffis, B.K. Jha, Y. Kumagai, O. Takeuchi, P. Hertzog, R.H. Silverman, S. Akira, D.J. Barton, M.S. Diamond, and A.A. Khromykh. 2012. West Nile virus non-coding subgenomic RNA contributes to viral evasion of type I interferon-mediated antiviral response. J. Virol. In Press.
• Kempf BJ, Barton DJ. Picornavirus RNA polyadenylation by 3D(pol), the viral RNA-dependent RNA polymerase. Virus Res. 2015 Jan 3. [Epub ahead of print] PubMed PMID: 25559071
• Cooper D., A. Khromykh, S.M. Lemon, R.H. Silverman and D.J. Barton. 2011. Exploring the susceptibility of positive-strand RNA genomes to cleavage by RNase L. American Society For Virology Annual Meeting, University of Minnesota, Minneapolis, MN, July 16-20.
• Kempf, B.J., O.B. Peersen, and D.J. Barton. 2011. Features of poliovirus 3D polymerase that affect the length of 3’ poly(A) tails in viral RNA. American Society For Virology Annual Meeting, University of Minnesota, Minneapolis, MN, July 16-20.
• Kempf, B.J., M.M. Kelly, O.B. Peersen, and D.J. Barton. 2012. Telomerase-like Activity of Poliovirus RNA-dependent RNA polymerase. American Society For Virology Annual Meeting, University of Wisconsin, Madison, WI, July 21-25.
• Kempf BJ, Barton DJ. Picornavirus RNA polyadenylation by 3D(pol), the viral RNA-dependent RNA polymerase. Virus Res. 2015 Aug 3;206:3-11. PubMed PMID: 25559071
• Cooper, D.A., J.R. Hesselberth, H.R. Rosen, R.H. Silverman and D.J. Barton. 2012. Methods to detect and identify RNA fragments produced by RNase L. American Society For Virology Annual Meeting, University of Wisconsin, Madison, WI, July 21-25.
• Cooper DA, Banerjee S, Chakrabarti A, García-Sastre A, Hesselberth JR, Silverman RH, Barton DJ. RNase L targets distinct sites in influenza A virus RNAs. J Virol. 2015 Mar;89(5):2764-76. PubMed PMID: 25540362
• Kempf, B.J., M.M. Kelly, C. Springer, O.B. Peersen, and D.J. Barton. 2013. Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA. J. Virol. In Press.
• Schuessler, A., A. Funk, H. Lazear, D.A. Cooper, S. Torres, S. Daffis, B.K. Jha, Y. Kumagai, O. Takeuchi, P. Hertzog, R.H. Silverman, S. Akira, D.J. Barton, M.S. Diamond, and A.A. Khromykh. 2012. West Nile virus non-coding subgenomic RNA contributes to viral evasion of type I interferon-mediated antiviral response. J. Virol. 86:5708-5718.
• Kortus, M.G., B.J. Kempf, K.G. Haworth, D.J. Barton, O.B. Peersen. 2012. A template RNA entry channel in the fingers domain of poliovirus polymerase. J. Mol. Biol. 417:263-278.
• Shimikami, T., D. Yamane, R.K. Jangra, B.J. Kempf, C. Spaniel, D.J. Barton, S.M. Lemon. 2012. Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc. Natl. Acad. Sci. USA 109:941-946. Selected by Faculty of 1000 (Top 2% of Published Articles in Biology and Medicine)
• Kempf BJ, Peersen OB, Barton DJ. Poliovirus Polymerase Leu420 Facilitates RNA Recombination and Ribavirin Resistance. J Virol. 2016 Oct 1;90(19):8410-21. PubMed PMID: 27412593
• Kempf BJ, Watkins CL, Peersen OB, Barton DJ. Picornavirus RNA Recombination Counteracts Error Catastrophe. J Virol. 2019 Jul 15;93(14). PubMed PMID: 31068422
• Kempf, B.J., C.L. Watkins, O.B. Peersen and D.J. Barton. (2019) An extended primer grip of picornavirus polymerase facilitates sexual RNA replication mechansims. BioRxiv 876292 [Preprint]. Dec. 16, 2019. Available from: https://www.biorxiv.org/content/10.1101/2019.12.13.876292v1
• Ancar R, Li Y, Kindler E, Cooper DA, Ransom M, Thiel V, Weiss SR, Hesselberth JR, Barton DJ. Physiologic RNA targets and refined sequence specificity of coronavirus EndoU. RNA. 2020 Dec;26(12):1976-1999. PubMed PMID: 32989044
• Kempf BJ, Watkins CL, Peersen OB, Barton DJ. An Extended Primer Grip of Picornavirus Polymerase Facilitates Sexual RNA Replication Mechanisms. J Virol. 2020 Jul 30;94(16). PubMed PMID: 32522851
• Watkins CL, Kempf BJ, Beaucourt S, Barton DJ, Peersen OB. Picornaviral polymerase domain exchanges reveal a modular basis for distinct biochemical activities of viral RNA-dependent RNA polymerases. J Biol Chem. 2020 Jul 31;295(31):10624-10637. PubMed PMID: 32493771