Xianzhong Meng, MD, PhD

Professor, Surgery-Cardiothoracic

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Languages
English
Department
Surgery-Cardiothoracic

Professional Titles

  • Profesor

Publications

  • Yao Q, The E, Nedumaran B, Zhai Y, Ao L, Fullerton DA, Meng X. Cathepsin D elevates the fibrocalcific activity in human aortic valve cells through the ERK1/2-Sox9 pathway. Front Cardiovasc Med 11:1410862, 2024
  • The E, Yao Q, Ao L, Zhai Y, Fullerton DA, Meng X. Molecular interaction of soluble Klotho with FGF23 in the pathobiology of aortic valve lesions induced by chronic kidney disease. Int J Biol Sci 20:3412-3425, 2024
  • Pratap A, Qualman A, Garrett H, The E, Chauhan A, Idrovo J, Chen L, Wani S, Meguid R, Meng X. Targeting glypican 1 reverses resistance to 5-fluorouracil in esophageal adenocarcinoma cells. Anticancer Res 43:3411-3418, 2023
  • The E, Zhai Y, Yao Q, Ao l, Li S, Fullerton DA, Dinarello CA, Meng X. Recombinant IL-37 exerts an anti-inflammatory effect on human aortic valve interstitial cells through extracellular and intracellular actions. Int J Biol Sci 19:3908–3919, 2023
  • Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Meng X. Aging exacerbates cardiac dysfunction and mortality in sepsis through enhancing TLR2 activity. Front Cardiovasc Med 10:1293866, 2023
  • Deng X, Meng X, Fullerton DA, Stone M, Iguidbashian J, Jaggers J. Complement cross talks with H-K-ATPase to up-regulate Runx-2 in human aortic valve interstitial cells. J Surg Res 286:118-126, 2023
  • Li X, Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Yu K, Meng X. Up-regulation of myocardial klotho expression to promote cardiac functional recovery in old mice following endotoxemia. Research Square
  • Pratap A, Qualman A, Garrett H, Westbrook L, The E, Mitra S, Cordero M, Monge KM, Idrovo JP, Chauhan A, Cheng L, Cohen MJ, Mungo B, Wani S, Meguid RA, McCarter MD, Meng X. Silencing Glypican-1 enhances the antitumor effects of Pictilisib via downregulating PI3K/Akt/ERK signaling in chemo-resistant esophageal adenocarcinoma. Mol Cell Oncol 10:2238873, 2023.
  • The E, deGraaf DM, Zhai Y, Yao Q, Ao L, Fullerton DA, Dinarello CA, Meng X. Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. Proc Nat Acad Sci USA 119(36):e2202577119, 2022
  • Pratap A, Li A, Westbrook L, Gergen AK, Mitra S, Chauhan A, Chen L, Weyant ML, McCarter M, Wani S, Meguid R, Mitchell JD, Cohen M, Fullerton DA, Meng X. Glypican 1 is a prognostic marker and promotes neoplastic properties I esophagogastric adenocarcinoma. J Gastrointest Oncol 13:2082-2104, 2022
  • Luo Z, The E, Zhang P, Zhai Y, Yao Q, Ao L, Zeng Q, Fullerton DA, Meng X. Monocytes Augment Inflammatory Responses in Human Aortic Valve Interstitial Cells via ß2-Integrin/ICAM-1-Mediated Signaling. Inflamm Res 71:681-694, 2022
  • Gergen AK, Madsen HJ, Li A, Cheng L, Meng X, Fullerton DA, Pratap A, Weyant MJ. Simvastatin inhibits histologic changes associated with gastroduodenal reflux in a murine model. Digest Dis Sci 67:4732-4741, 2022
  • Zhai Y, Ao L, Yao Q, The E, Fullerton DA, Meng X. Elevated expression of TLR2 in aging hearts exacerbates cardiac inflammatory response and adverse remodeling following ischemia and reperfusion injury. Front Immunol 13:891570, 2022
  • Li J, Zeng Q, Xiong Z, Xian G, Liu Z, Zhan Q, Lai W, Ao L, Meng X, Ren H, Xu D. Trimethylamine-N-oxide induces osteogenic responses in human aortic valve interstitial cells in vitro and aggravates aortic valve lesions in mice. Cardiovac Res 118:2018-2030, 2022
  • Zhang P, The E, Luo Z, Zhai Y, Yao Q, Ao L, Fullerton DA, Xu D, Meng X. Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity. Mol Med 28(1):5, 2022
  • Gergen AK, Jarrett MJ, Li A, Cheng L, Tilva KR, Madsen HJ, Meng X, Fullerton DA, Weyant MJ. Expression of adhesion molecules in a gastroduodenal reflux murine model. Ann Thorac Surg 113:926-933, 2022
  • Venardos N, Gergen AK, Jarrett MJ, Weyant MJ, Reece TB, Meng X, Fullerton DA. Warfarin induces calcification of the aortic valve via ERK1/2 and ß-catenin signaling. Ann Thorac Surg 113:824-835, 2022
  • Ikeno Y, Ghincea CV, Roda GF, Cheng L, Aftab M, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Optimizing nicorandil for spinal cord protection in a murine model of complex aortic intervention. Semin Thorac Cardiovasc Surg 34:28-38, 2022
  • Halpern AL, Kohtz PD, White AM, Houk AK, Rehring JF, Hanson L, McCarter MD, Joshi M, Meng X, Fullerton DA, Weyant MJ. Secretory phospholipase A2 IIa mediates expression of growth factor receptors in esophageal adenocarcinoma. Dig Dis Sci 66:784-795, 2021
  • Gergen AK, Jarrett MJ, Li A, White AM, Meng X, Fullerton DA, Weyant MJ. Secretory phospholipase A2 inhibition attenuates adhesive properties of esophageal Barrett’s cells. J Surg Res 259:562-568, 2021
  • Gergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJ. Statins inhibit Toll-like receptor 4-mediated growth of human esophageal adenocarcinoma cells. J Surg Res 260:436-447, 2021
  • Zhao P, Yao Q, Zhang P, The E, Zhai Y, Ao L, Jarret MJ, Dinarello DA, Fullerton DA, Meng X. Single-cell RNA-seq reveals novel proinflammatory EndMT in human coronary artery-on-a-chip under atheroprone flow. Science Advances 7(34):eabg1694, 2021
  • Jarrett MJ, Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA. Wnt signaling mediates pro-fibrogenic activity in human aortic valve interstitial cells. Ann Thorac Surg 112:519-525, 2021
  • Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin downregulates osteogenic response in cultured human aortic valve interstitial cells. J Thorac Cardiovasc Surg 161:e261-e271, 2021
  • Deng X, Meng X, Fullerton DA, Stone M, Jaggers J. Complement up-regulates Runx-2 to induce pro-fibrogenic change in human aortic valve interstitial cells. Ann Thorac Surg 112:1962-1972, 2021
  • The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton DA, Meng X. Mechanistic roles of matrilin-2 and Klotho in modulating the inflammatory activity of human aortic valve cells. Cells 9:385, 2020.
  • Yao Q, The E, Ao L, Zhai Y, Osterholt MK, Fullerton DA, Meng X. TLR4 stimulation promotes human AVIC fibrogenic activity through upregulation of neurotrophin 3 production. Int J Mol Sci 21:1276, 2020.
  • Zhang P, The E, Nedumaran B, Ao L, Jarrett MJ, Xu D, Fullerton DA, Meng X. Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level. Int J Biol Sci 16:3062-3074, 2020.
  • Zhou P, Li Q, Su S, Dong W, Zong S, Ma Q, Yang X, Zuo D, Zheng S, Meng X, Xu D, Zeng Q. Interleukin 37 suppresses M1 macrophage polarization through inhibition of the Notch1 and nuclear factor kappa B pathways. Front Cell Dev Biol 8:56, 2020.
  • Gergen AK, Kohtz PD, Halpern AL, LI A, Meng X, Reece TB, Fullerton DA, Weyant MJ. Activation of Toll-like receptor 2 promotes proliferation of human lung adenocarcinoma cells. Anticancer Res 40:5361-5369, 2020.
  • Song R, Zhai Y, Ao L, Fullerton DA, Meng X. MicroRNA-204 deficiency in human aortic valves elevates valvular osteogenic activity. Int J Mol Sci, 21:e76, 2019. (open access)
  • Halpern AL, Kohtz PD, Meng X, Rove J, Fullerton DA, Weyant MJ. Inhibition of secretory phospholipase A2 IIa attenuates prostaglandin E2 induced invasiveness in lung adenocarcinoma. Mol Cell Biochem 456:145-156, 2019.
  • Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Azam T, Zhang L, Zhao R, Kieft J, The E, Meng X, Dinarello CA. The interleukin-37 monomer is the active form for reducing innate immunity. Proc Nat Acad Sci USA 116:5514-5522, 2019.
  • Deng XS, Meng X, Li F, Venardos N, Fullerton D, Jaggers J. MMP-12-Induced Pro-osteogenic Responses in Human Aortic Valve Interstitial Cells. J Surg Res 235:44-51, 2019.
  • Lee DJ, Cavasin MA, Rocker AJ, Soranno DE, Meng X, Shandas R, Park D. An injectable sulfonated reversible thermal gel for therapeutic angiogenesis to protect cardiac function after a myocardial infarction. J Biol Engineering 13:6, 2019 (open access).
  • Kohtz PD, Halpern AL, Hazel KD, Eldeiry MA, Yamanaka K, Kalatardi, S, Sjoberg AJ, Ao L, Meng X, Reece TB, Fullerton DA, Weyant MJ. Toll-like receptor-4 is a mediator of proliferation in esophageal adenocarcinoma. Ann Thorac Surg 107:233-241, 2019.
  • Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Meng X, Weyant MJ, Fullerton DA, Reece TB. Synergetic induction of NGF with diazoxide and erythropoietin attenuates spinal cord ischemic injury. J Surg Res 233:124-131, 2019.
  • Liu Z, Li J, Liu H, Tang Y, Zhan Q, Lai W, Ao L, Meng X, Ren H, Xu D, Zeng Q. The intestinal microbiota associated with cardiac valve calcification differs from that of coronary artery disease. Atherosclerosis 284:121-128, 2019.
  • Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Roda G, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Reece TB. Pretreatment with diazoxide attenuates spinal cord ischemia-reperfusion injury through STAT3 pathway. Ann Thorac Surg 107:733-739, 2019.
  • Yamanaka K, Eldeiry M, Aftab M, Mares J, Ryan TJ, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Reece TB. Optimized induction of beta common receptor enhances the neuroprotective function of erythropoietin in spinal cord ischemic injury. J Thorac Cardiovasc Surg 155:2505-2516, 2018.
  • Wang S, Ge W, Harns C, Meng X, Zhang Y, Ren J. Ablation of Toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy. J Mol Cell Cardiol 119:40-50, 2018.
  • Venardos N, Deng X, Yao Q, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin reduces the TLR4-induced inflammatory responses in human aortic valve interstitial cells. J Surg Res 230:101-109, 2018.
  • Deng X, Meng X, Li F, Venardos N, Fullerton DA, Jaggers J. MMP-12–induced pro-osteogenic responses in human aortic valve interstitial cells. J Surg Res 235:44-51, 2018.
  • Yamanaka K, Eldeiry M, Aftab M, Ryan TJ, Mares J, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Reece TB. Synergistic reduction of apoptosis with Diazoxide and erythropoietin in spinal cord ischemic injury. Ann Thorac Surg 106:1751-1758, 2018.
  • Li F, Song R, Ao L, Reece TB, Cleveland JC, Dong N, Fullerton DA, Meng X. ADAMTS5 deficiency in calcified aortic valves is associated with elevated pro-osteogenic activity in valvular interstitial cells. Arterioscler Thromb Vasc Biol 37:1339-1351, 2017.
  • Li F, Yao Q, Ao L, Cleveland JC, Dong N, Fullerton DA, Meng X. Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9. J Mol Med 95:739-751, 2017.
  • Song R, Fullerton DA, Ao L, Zhao K, Meng X. An epigenetic regulatory loop controls pro-osteogenic activation by TGF-ß1 or bone morphogenetic protein 2 in human aortic valve interstitial cells. J Biol Chem 292:8657-8666, 2017.
  • Yao Q, Song R, Ao L, Cleveland JC, Fullerton DA, Meng X. Neurotrophin 3 up-regulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis. Am J Physiol Cell Physiol 312:C697-C706, 2017.
  • Zhan Q, Zeng Q, Song R, Zhai Y, Xu D, Fullerton DA, Dinarello CA, Meng X. IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitial cells. Mol Med 23:83-91, 2017.
  • Cheng H, Yao Q, Song R, Zhai Y, Wang W, Fullerton DA, Meng X. LysoPC activates the Akt pathway to up-regulate ECM protein production in human aortic valve cells. J Surg Res 213:243-250, 2017.
  • Song R, Fullerton DA, Ao L, Zhao K, Reece TB, Cleveland JC, Meng X. Altered microRNA expression is responsible for the pro-osteogenic phenotype of interstitial cells in calcified human aortic valves. J AHA 6:e005364, 2017.
  • Hui H, Zhai Y, Ao L, Cleveland JC, Liu H, Fullerton DA, Meng X. Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget 8:15663-15676, 2017.
  • Zhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, Fullerton DA, Meng X. Double-stranded RNA up-regulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-non-canonical NF-?B pathway. Am J Physiol Cell Physiol 312:C407-C417, 2017.
  • Li J, Zhai Y, Ao L, Hui H, Fullerton DA, Dinarello CA, Meng X. Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice. Cytokine 95:55-63, 2017.
  • Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC Jr, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X. Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc Nat Acad Sci USA 114:1631-1636, 2017.
  • Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC. LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol 101:261-273, 2017.
  • Deng X, Meng X, Song R, Fullerton DA, Jaggers J. Autophagy negatively regulates pro-osteogenic activity in human aortic valve interstitial cells. J Surg Res 218:285-291, 2017.
  • Howell KW, Cleveland JC, Meng X, Ao L, Su X, Schwartz RS, Fullerton DA. Interleukin 6 production during cardiac surgery correlates with increasing age. J Surg Res 201:76-81, 2016.
  • Deng X, Meng X, Song R, Fullerton DA, Jaggers J. Rapamycin suppresses the osteogenic response in aortic valve interstitial cells via the Stat3 pathway. Ann Thorac Surg 102:1229-1238, 2016.
  • Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC. LysoPCs induce Hck- and PKCd-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol, in press.
  • Deng X, Meng X, Zeng Q, Fullerton DA, Mitchell MB, Jaggers J. Adult aortic valve interstitial cells have greater responses to Toll-like receptor 4 stimulation. Ann Thorac Surg 99:62-71, 2015.
  • Zhan Q, Song R, Zeng Q, Yao Q, Ao L, Xu D, Fullerton DA, Meng X. Activation of TLR3 induces an osteogenic response in human aortic valve interstitial cells through the NF-?B and ERK1/2 pathways. Int J Biol Sci 11:482-493, 2015.
  • Song R, Fullerton DA, Ao L, Zheng D, Zhao K, Meng X. BMP-2 and TGF-ß1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells. J Mol Med 93:403-412, 2015.
  • Zhai Y, Ao L, Cleveland JC Jr, Zeng Q, Reece TB, Fullerton DA, Meng X. Toll-like receptor 4 mediates the inflammatory responses and matrix protein remodeling in remote non-ischemic myocardium in a mouse model of myocardial ischemia and reperfusion. PloS One 10(3):e0121853, 2015.
  • Venardos N, Nadlonek NA, Weyant MJ, Reece, TB, Meng X, Fullerton DA. Matrix Gla protein regulates calcification of the aortic valve. J Surg Res 199:1-6, 2015.
  • Yao Q, Song R, Ao L, Zhan Q, Cleveland JC, Yu X, Fullerton DA, Meng X. Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. BBA Mol Basis Dis 1852:1940-1949, 2015.
  • Li J, Ao L, Zhai Y, Cleveland JC, Fullerton DA, Meng X. Gender disparity in the role of TLR2 in post-ischemic myocardial inflammation and injury. Int J Clin Exp Med 8:10537-10547, 2015.
  • Li P, Meng X, Bian H, Burns N, Zhao KS, Song R. Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage. Oncotarget 6:36998-37011, 2015.
  • White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D. NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. J Mol Cell Cardiol 84:13-23, 2015.
  • Bennett DT, Reece TB, Foley LS, Sjoberg A, Meng X, Fullerton DA, Weyant MJ. C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator of transcription 3. J Thorac Cardiovasc Surg 149-369-375, 2015.
  • Freeman KA, Fullerton DA, Foley LS, Bell MT, Cleveland JC Jr, Weyant MJ, Mares J, Meng X, Puskas F, Reece TB. Spinal cord protection via alpha-2 agonist-mediated increase in glial cell-line-derived neurotrophic factor. J Thorac Cardiovasc Surg 149:578-586, 2015.
  • Mares J, Foley LS, Bell M, Bennett D, Freeman K, Meng X, Weyant M, Cleveland JC, Fullerton DA, Puskas F, Reece BB. Erythropoietin activates pCREB pathway and attenuates delayed paraplegia following spinal cord ischemia and reperfusion injury. J Thorac Cardiovasc Surg 149:920-924, 2015.
  • Foley LS, Fullerton DA, Bennett DT, Freeman KA, Mares J, Bell MT, Cleveland JC Jr, Weyant MJ, Meng X, Puskas F, Reece TB. Spinal cord ischemia-reperfusion injury induces erythropoietin receptor expression. Ann Thorac Surg 100:41-46, 2015.
  • Wang D, Zeng Q, Song R, Ao L, Fullerton DA, Meng X. Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: a critical role of the Notch1–NF-kapaB pathway in BMP-2 expression. BBA Mol Cell Res 1843:2744-2753, 2014.
  • Slimani H, Zhai Y, Yousif NG, Ao L. Zeng Q, Fullerton DA, Meng X. Enhanced monocyte chemoattractant protein-1 production in aging mice exaggerates cardiac depression during endotoxemia. Crit Care 18(5):527, 2014. (open access)
  • Jin C, Cleveland JC, Ao L, Li J, Zeng Q, Fullerton DA, Meng X. Human myocardium releases heat shock protein (HSP) 27 following global ischemia: the pro-inflammatory effect of extracellular HSP27 through TLR2 and TLR4. Mol Med 20:280-289, 2014.
  • Song R, Ao L, Zhao K, Zheng D, Venardos N, Fullerton DA, Meng X. Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway. Inflamm Res 63:703-710, 2014.
  • Zeng Q, Song R, Ao L, Xu D, Venardos N, Fullerton DA, Meng X. Augmented osteogenic responses in human aortic valve cells exposed to oxLDL and TLR4 agonist: a mechanistic role of Notch1 and NF-kapaB interaction. Plos One 9:e95400, 2014. (open access)
  • Bennett DT, Deng XS, Yu JA, Bell MT, Mauchley DC, Meng X, Reece TB, Fullerton DA, Weyant MJ. Cancer Stem Cell Phenotype Is Supported by Secretory Phospholipase A2 in Human Lung Cancer Cells. Ann Thorac Surg 98:439-446, 2014.
  • Venardos N, Nadlonek NA, Zhan Q, Weyant MJ, Reece, TB, Meng X, Fullerton DA. Aortic valve calcification is mediated by a differential response of aortic valve interstitial cells to inflammation. J Surg Res 190:1-8, 2014.
  • Up-regulated expression of neurotrophin 3 in the interstitial cells of stenotic aortic valves may promote valvular fibrosis. American Heart Association Scientific Sessions 2014
  • Epigenetic up-regulation of a-smooth muscle actin expression and cell aggregation in human aortic valve interstitial cells promotes calcific nodule formation. American Heart Association Scientific Sessions 2014
  • IL-37 suppresses the enhanced inflammatory responses and cardiac contractile depression in aging endotoxemic mice. Annual Conference on Shock 2014
  • Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and NF-?B activation. Arterioscler Thromb Vasc Biol, in press.
  • Secretory phospholipase A2 mediates human esophageal adenocarcinoma cell growth and proliferation via ERK 1/2 pathway. Anticancer Res, in press.
  • Zeng Q, Song R, Ao L, Weyant MJ, Lee J, Xu D, Fullerton DA, Meng X. Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and NF-?B activation. Arterioscler Thromb Vasc Biol 33:1580-1590, 2013.
  • Nadlonek, Lee J, Weyant MJ, Meng X, Fullerton DA. OxLDL induces Pit-1 expression in human aortic valve interstitial cells. J Sur Res 184:6-9, 2013.
  • Nadlonek, Lee J, Weyant MJ, Cleveland JC, Reece B, Meng X, Fullerton DA. Interleukin-1 beta induces an inflammatory phenotype in human aortic valve interstitial cells via NF-kappaB. Ann Thorac Surg 96:155-162, 2013.
  • Smith PD, Bell MT, Puskas F, Meng X, Cleveland JC Jr, Weyant MJ, Fullerton DA, Reece TB. Preservation of motor function after spinal cord ischemia and reperfusion injury through microglial inhibition. Ann Thorac Surg 95:1647-1653, 2013.
  • Bell MT, Smith PD, Puskas F, Meng X, Cleveland JC Jr, Weyant MJ, Fullerton DA, Reece TB. Toll-like receptor 4 dependent microglial activation mediates spinal cord ischemia-reperfusion injury. Circulation 128:S152-S156, 2013.
  • Sadaria MR, Yu JA, Meng X, Fullerton DA, Reece TB, Weyant MJ. Secretory phospholipase A2 mediates human esophageal adenocarcinoma cell growth and proliferation via ERK 1/2 pathway. Anticancer Res 33:1337-1342, 2013.
  • TLR4 mediates the inflammatory response of remote non-ischemic myocardium and contributes to heart failure in a mouse model of myocardial infarction. Annual Conference on Shock 2013
  • Exaggerated cardiac contractile depression in aging endotoxemic mice is associated with enhanced inflammatory responses. Annual Conference on Shock 2013
  • MicroRNA-204 and -486 regulate the expression of osteogenic transcription factors in human aortic valve cells: evidence for epigenetic modulation of valvular cell osteogenic reprogramming. American Heart Association Scientific Sessions 2013
  • Neurotrophin 3 induces the expression of TGF-ß1 and BMP-2 in human aortic valve interstitial cells via Trk receptors. American Heart Association Scientific Sessions 2013
  • Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo. J Thorac Cardiovasc Surg 144:1185-1191, 2012.
  • sPLA2 IIa expression correlates with sPLA2 IIa inhibition-mediated cell death in K-Ras mutant lung cancer cells. J Thorac Cardiovasc Surg 144:1479-1485, 2012.
  • Radiation induces osteogenesis in human aortic valve interstitial cells. J Thorac Cardiovasc Surg 144:1466-1470, 2012.
  • Attenuation of spinal cord ischemia-reperfusion injury by specific a-2a receptor activation with dexmedetomidine. J Vasc Surg 56:1398-1402, 2012.
  • The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury. Circulation 126:S110-S117, 2012.
  • Group IIa sPLA2 Inhibition Attenuates NF-?B Activity and Promotes Apoptosis of Lung Cancer Cells. Anticancer Res 32:3601-3607, 2012.
  • Yu J, Sadaria MR, Meng X, Mitra S, Ao L, Fullerton DA, Weyant MJ. Lung cancer cell invasion and expression of intercellular adhesion molecule-1 (ICAM-1) are attenuated by secretory phospholipase A2 inhibition. J Thorac Cardiovasc Surg 143:405-411, 2012.
  • Benson DD, Meng X, Fullerton DA, Moore EE, Lee JH, Ao L, Silliman CC, Barnett CC Jr. Activation state of stromal inflammatory cells in murine metastatic pancreatic adenocarcinoma. Am J Physiol Regul Integ Comp Physiol, in press.
  • Eun JC, Moore EE, Mauchley DC, Johnson CA, Meng X, Banerjee A, Wohlauer MV, Zarini S, Gijón MA, Murphy RC. The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock. Shock, in press.
  • Cross-talk between the Toll-like receptor 4 and Notch1 pathways augments the inflammatory response in the interstitial cells of stenotic human aortic valves. Circulation 126:S222-S230, 2012.
  • Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor 2. Arterioscler Thromb Vasc Biol 32:2711-2720, 2012.
  • Howell KW, Meng X, Fullerton DA, Jin C, Reece TB, Cleveland JC Jr. Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cells. J Surg Res 171:e27-31, 2011.
  • Abohashem-Aly AA, Meng X, Li J, Sadaria MR, Ao L, Wennergren J, Fullerton DA, Raeburn CD. DITPA, A Thyroid Hormone Analog, Reduces Infarct Size and Attenuates the Inflammatory Response Following Myocardial Ischemia. J Surg Res 171:379-385, 2011.
  • Sadaria MR, Meng X, Fullerton DA, Reece TB, Shah RR, Grover FL, Weyant MJ. Secretory phospholipase A2 inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cells. Ann Thorac Surg 91:1539-1545, 2011.
  • Su X, Ao L, Shi Y, Fullerton DA, Meng X. Oxidized low-density lipoprotein induces bone morphogenetic protein-2 in coronary endothelial cells via Toll-like receptors 2 and 4. J Biol Chem 286:12213-20, 2011.
  • Yong S, Fullerton DA, Mauchley D, Su X, Ao L, Yang X, Cleveland JC Jr, Meng X. Microfilaments facilitate TLR4-mediated ICAM-1 expression in human aortic valve interstitial cells. J Surg Res 166:52-58, 2011.
  • Su X, Ao L, Shi Y, Fullerton DA, Meng X. Oxidized low-density lipoprotein induces bone morphogenetic protein-2 in coronary endothelial cells via Toll-like receptors 2 and 4. J Biol Chem, in press.
  • Smith PD, Puskas F, Fullerton DA, Meng X, Cho D, Cleveland JC Jr, Weyant MJ, Reece TB. Attenuation of spinal cord ischemia and reperfusion injury by erythropoietin. J Thorac Cardiovasc Surg 141:256-260, 2011.
  • Lee JH, Meng X, Weyant MJ, Reece TB, Cleveland JC Jr, Fullerton DA. Stenotic aortic valves have dysfunctional mechanisms of anti-inflammation: implications for aortic stenosis. J Thorac Cardiovasc Surg 141:481-486, 2011.
  • Sadaria MR, Meng X, Fullerton DA, Reece TB, Shah RR, Grover FL, Weyant MJ. Secretory phospholipase A2 inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cells. Ann Thorac Surg, in press.
  • Mauchley D, Meng X, Johnson T, Teitelbaum J, Babu A, Fullerton DA, Weyant MJ. Heat shock protein 27: Induction by gastroduodenal reflux in vivo and augmentation of human esophageal mucosal cell growth in vitro. J Thorac Cardiovasc Surg 139:1019-1025, 2010.
  • Mauchley D, Meng X, Johnson T, Fullerton DA, Weyant MJ. Modulation of growth in human esophageal adenocarcinoma cells by group IIa secretory phospholipase A(2). J Thorac Cardiovasc Surg 139:591-599; 2010.
  • Benson DD, Kelher MR, Meng X, Fullerton DA, Lee JH, Silliman CC, Barnett CC Jr. Gender-specific transfusion affects tumor-associated neutrophil: macrophage ratios in murine pancreatic adenocarcinoma. J Gastrointest Surg 14:1560-1565, 2010.
  • Mauchley D, Meng X, Babu A, Gamboni-Robertson F, Yang X, Banerjee A, Fullerton DA, Weyant MJ. Gastroduodenal reflux induces group IIa secretory phospholipase A(2) expression and activity in murine esophagus. Dis Esophagus 23:430-436, 2010.
  • Li J, Jin C, Cleveland JC, Ao L, Xu D, Fullerton DA, Meng X. Enhanced inflammatory responses to Toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin. Cardiovasc Diabetol 9:90, 2010.
  • Su X, Sykes JB, Ao L, Raeburn CD, Fullerton DA, Meng X. Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue. Cytokine 51:60-66, 2010.
  • Kohtz PD, Halpern AL, Hazel KD, Eldeiry MA, Yamanaka K, Kalatardi, S, Sjoberg AJ, Ao L, Meng X, Reece TB, Fullerton DA, Weyant MJ. Toll-like receptor-4 is a mediator of proliferation in esophageal adenocarcinoma. Ann Thorac Surg, in press.
  • Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Azam T, Zhang L, Zhao R, Kieft J, The E, Meng X, Dinarello CA. The interleukin-37 monomer is the active form for reducing innate immunity. PNAS, in press.
  • Halpern AL, Kohtz PD, Meng X, Rove J, Fullerton DA, Weyant MJ. Inhibition of Secretory Phospholipase A2 IIa Attenuates Prostaglandin E2 Induced Invasiveness in Lung Adenocarcinoma. Mol Cell Biochem, in press.
  • Jan B, Lau J, Ao L, Meng X, Ren H, Xu D, Zeng Q. The intestinal microbiota associated with cardiac valve calcification differs from that of coronary artery disease. Atherosclerosis, in press.
  • Halpern AL, Kohtz PD, White AM, Houk AK, Rehring JF, Hanson L, McCarter MD, Joshi M, Meng X, Fullerton DA, Weyant MJ. Secretory phospholipase A2 IIa mediates expression of growth factor receptors in esophageal adenocarcinoma. Dig Dis Sci, in press.
  • Jarrett MJ,Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA. Wnt signaling mediates pro-fibrogenic activity in human aortic valve interstitial cells. Ann Thorac Surg, in press.
  • Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin downregulates osteogenic response in cultured human aortic valve interstitial cells. J Thorac Cardiovasc Surg, in press.
  • Ikeno Y, Ghincea CV, Roda GF, Cheng L, Aftab M, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Optimizing nicorandil for spinal cord protection in a murine model of complex aortic intervention. Semin Thorac Cardiovasc Surg, in press.
  • Gergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJ. Statins inhibit Toll-like receptor 4-mediated growth of human esophageal adenocarcinoma cells. J Surg Res, in press.
  • Ao L, Zhai Y, Jin C, Cleveland JC, Fullerton DA, Meng X. Attenuated recovery of contractile function in aging hearts following global ischemia/reperfusion: Role of extracellular HSP27 and TLR4. Mol Med, in press
  • Hui H, Zhai Y, Ao L, Cleveland JC, Liu H, Fullerton DA, Meng X. Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget, in press
  • Zhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, Fullerton DA, Meng X. Double-stranded RNA up-regulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-non-canonical NF-?B pathway. Am J Physiol Cell Physiol, in press
  • Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC Jr, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X. Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc Nat Acad Sci USA, in press
  • Venardos N, Gergen AK, Jarrett MJ, Weyant MJ, Reece TB, Meng X, Fullerton DA. Warfarin induces calcification of the aortic valve via ERK1/2 and ß-catenin signaling. Ann Thorac Surg, in press
  • Li X, Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Yu K, Meng X. Aging impairs the capacity of cardiac functional recovery following endotoxemia: modulation of myocardial Klotho level for remedy. J Surg Res, in press

Professional Memberships

  • American Heart Association, Scientific Concil member
  • Shock Society, Award Committee member
  • American Physiology Society, member
  • International Society of Heart Research, member
  • Society of Critical Care Medicine, member
Public Speaking
Yes



School of Medicine

CU Anschutz
Fitzsimons Building

13001 East 17th Place

Aurora, CO 80045

303.724.5375

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General
Students