V. Michael Holers, MD

Hibbert, R.G., Teriete, P., Grundy, G.J., Holers, V.M., Hannan, J.P., Sutton, B.J., Gould, H.J. and McDonnell, J.M. 2005. The structure of soluble CD23 and its interactions with IgE and CD21. J. Exp. Med 202:751-760.

Birrell, L., Kulik, L., Morgan, B.P., Holers, V.M., and Marchbank, K.J., 2005. B cells from mice prematurely expressing human CR2/CD21 are unresponsive to T-dependent antigens. J. Immunol. 174:6974-6982.

Atkinson, C., Song, H., Lu, B., Qiao, F., Burns, T.A., Holers, V.M., Tsokos, G.C., and Tomlinson, S. 2005. Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. J. Clin. Invest. 115:2444-2453.

Thurman, J.M., Kraus, D.M., Girardi, G., Hourcade, D., Kang, H.J., Royer, P.A., Mitchell, L.M., Giclas, P.C., Salmon, J.E., Gilkeson, G.S., and Holers, V.M. 2005. A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice. Mol. Immunol. 42:87-97.

Ferucci, E.D., Majka, D.S., Parrish, L.A., Moroldo, M.B., Ryan, M., Passo, M., Thompson, S.D., Deane, K.D., Rewers, M., Arend, W.P., Glass, D.N., Norris, J.M., and Holers, V.M. 2005. Antibodies against citrullinated peptide (CCP) are associated with HLA-DR4 in simplex and multiplex polyarticular juvenile rheumatoid arthritis. Arth. Rheum. 52:239-246.

Carroll, M.C., and Holers, V. M., 2005. Innate Autoimmunity in Advances in Immunology 86:137-157.

Holers, V. M. 2005. Complement receptors and the shaping of the natural antibody repertoire. Springer Semin. Immunopath. 26:405-423.

Liubchenko, G.A., Appleberry, H.C., Striebich, C.C., Franklin, K.E., Derber, L.A., Holers, V.M., and Lyubchenko, T. 2013. Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes. J. Autoimmun. 40:111-121. PMCID: PMC3546227

Hu, X., Holers, V. M., Thurman, J.M., Schoeb, T.R., Ramos, T.N., and Barnum, S.R. 2013. Therapeutic inhibition of the alternative complement pathway attenuates chronic EAE. Mol. Immunol. 54:302-308. PMCID: PMC3602149

Cordova, K.N., Willis, V.C., Haskins, K., and Holers, V.M. 2013. A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis. J. Immunol. 190:1457-1465. PMID: 23319740

Kuhn, K.A., Kulik, L., Tomooka, B., Braschler, K.J., Arend, W.P., Robinson, W.H., and Holers, V.M. 2006. Antibodies to citrulline-modified proteins enhance tissue injury in inflammatory arthritis. J. Clin. Invest. 116:961-973.

Strassheim, D., Renner, B., Panzer, S., Fuquay, R., Kulik, L. Ljubanovic, D., Holers, V.M., and Thurman, J.M. 2013. IgM contributes to glomerular injury in FSGS. J. Am. Soc. Neph. 24: 393-406. PMCID:PMC3582199

Banda, N.K., Mehta, G., Ferreira, V.P., Cortes, C., Pickering, M.C, Pangburn, M.K., Arend, W.P, and Holers, V.M. 2013. Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. J. Immunol. 190: 3560-3569. PMCID: PMC3607402

Thurman, J.M., Kulik, L, Orth, H., Wong, M., Renner, B., Sargsan, S.A., Mitchell, L.M., Hourcade, D.E., Hannan, J.P., Kovacs, J.M., Coughlin, B., Woodell, A.S., Pickering, M.C. Rohrer, B., and Holers, V.M. 2013. Detection of complement activation using monoclonal antibodies against C3d. J. Clin. Invest. 123: 2218-2230. PMCID: PMC 3635726

Taube, C., Thurman, J.M., Joetham, A., Takeda, K., Miyahara, N., Dakhama, A., Carroll, M.C., Giclas, P.C., Holers, V.M., and Gelfand, E.W. 2006. Factor B of the alternative pathway is critical to development of airway hyperresponsiveness. Proc. Natl. Acad. Sci. 103:8084-8089.

Joseph, K., Kulik, L., Coughlin, B., Kunchithapautham, K., Bandyopadhyay, M., Thiel, S., Thielens, N.M., Holers, V.M., and Rohrer, B. 2013. Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. J. Biol. Chem. 288: 12753-12765. PMCID: PMC3642321

Hughes-Austin, J.M., Deane, K.D., Derber, L.A., Kolfenbach, J.R., Zerbe, G.O., Sokolove, J, Lahey, L.J., Weisman, M.H., Buckner, J.H., Mikuls, T.R., O’Dell, J.R., Keating, R.M, Gregersen, P.K., Robinson, W.H., Holers, V.M., and Norris, J.M. 2013. Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis. Ann. Rheum. Dis. 72: 901-907. PMCID: PMC3726193

Keith, R.C., Sokolove, J., Edelman, B.L., Lahey, L., Redente, E.F., Holers, V.M., Sakaguchi, S., Robinson, W.H., and Riches, D.W. 2013. Testosterone is protective in theh sexually dimorphic development of arthritis and lung disease in SKG mice. Arth. Rheum. 65:1487-1493. PMCID: PMC3672393

Arend, W.P., Mehta, G., Antonioli, A.H., Takahashi, M., Takahashi, K., Stahl, G.L., Holers, V.M., and Banda, N.K. 2013. Role of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice. J. Immunol. 10:6423-6433. PMCID: PMC3679294

Young, K.A., Deane, K.D., Derber, L.A., Hughes-Austin, J.M., Wagner, C.A., Sokolove, J., Weisman, M.H., Buckner, J.H., Mikuls, T.R., O’Dell, J.R., Keating, R.M., Gregersen, P.K., Robinson, W.H., Holers, V.M., and Norris, J.M. 2013. Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis. Arth. Rheum. 65: 1995-2004. PMCID: PMC3729718

Demoruelle, M.K., Parish, M.C., Derber, L.A., Kolfenbach, J.R., Hughes-Austin, J.M., Weisman, M.H., Gilliland, W., Edison, J.D., Buckner, J.H., Mikuls, T.R., O’Dell, J.R., Keating, R.M., Gregersen, P.K., Holers, V.M., and Deane, K.D. 2013. Performance of anti-cyclic citrullinated peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease. Arth. Rheum. 65: 2243-2252. PMCID: PMC3776020

Gilbert, H.E., Aslam, M., Guthridge, J.M., Holers, V.M., and Perkins, S.J. 2006. Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: Implications for function and therapy. J. Mol. Biol. 356:397-412.

Gan, R.W., Deane, K.D., Zerbe, G.O., Demoruelle, M.K., Weisman, M.H., Buckner, J.H., Gregersen, P.K., Mikuls, T.R., O’Dell, J.R., Keating, R.M., Holers, V.M., and Norris, J.M. 2013. Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA. Ann. Rheum. Dis. 72:2002-2005. PMCID: PMC3828364

Thurman, J.M., Royer, P.A., Ljubanovic, D., Dursun, B., Lenderink, A.M., Edelstein, C.L., and Holers, V.M. 2006. Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury. J. Am. Soc. Nephrol. 17:707-715.

Walitt, B., Mackey, R., Kuller, L., Deane, K.D., Robinson, W., Holers, V.M., Chang, W.-F., and Moreland, L. 2013. Predictive value of autoantibody testing for validating self-reported diagnoses of rheumatoid arthritis in the Women’s Health Initiative. Am. J. Epidemiol. Mar 13 (Epub ahead of print). PMID:23492764

Willis, V.C, Demoruelle, M.K., Derber, L.A., Chartier-Logan, C.J., Parish, M.C., Pedraza, I.F., Weisman, M.H., Norris, J.M., Holers, V.M., and Deane, K.D. 2013. Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent disease. Arth. Rheum. 65:2545-2554. PMID:23817979

Wu, T.C., Yang, S., Haven, S., Holers, V.M., Lundberg, A.S., Wu, H., and Cataland, S.R. 2013. Complement activation and mortality during an acute episode of thrombotic thrombocytopenic purpura. J. Thromb. Haemost. 11:1925-1927. PMID:23927533

Kuller, L.H., Mackey, R.H., Walitt, B.T., Deane, K.D., Holers, V.M., Robinson, W.H., Sokolove, J., Chang, Y., and Moreland, L.W. 2013. Rheumatoid arthritis in the Women’s Health Initiative: methods and baseline evaluation. Am. J. Epidemiol. 179:917-926. PMCID: PMC3969537

Holers, V.M., Rohrer, B., and Tomlinson, S. 2013. CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation. Adv. Exp. Med. Biol. 734:137-154. PMID: 22990700

Holers, V.M., and Deane, K.D. 2013. Preclinical features of rheumatoid arthritis in Rheumatology 6th Edition (Ed, M.C. Hochberg, A.J. Silman, J.S. Smolen, M.H. Weisman and M.E. Weinblatt), Elsevier, Philadelphia, PA.

Holers, V.M. 2013. Human C3 glomerulopathy provides unique insights into complement factor H related protein function. J. Clin. Invest. 123:2357-2360. PMCID: PMC3668810

Whitcup, S.M., Sodhi, A., Atkinson, J.P., Holers, V.M., Sinha, D., Rohrer, B., and Dick, A.D. 2013. The role of the immune response in age-related macular degeneration. Intl. J. Inflamm. 2013:348092 PMCID:PMC3676958

Holers, V.M. 2013. Autoimmunity to citrullinated proteins and the initiation of rheumatoid arthritis. Curr. Opin. Immunol. 25:728-735. PMCID: PMC3895448

Pickering, M.C., D'Agati, V.D., Nester, C.M., Smith, R.J., Haas, M., Appel, G.B., Alpers, C.E., Bajema, I.M., Bedrosian, C., Braun, M., Doyle, M., Fakhouri, F., Fervenza, F,C., Fogo, A.B., Fremeaux-Bacchi, V., Gale, D.P., Goicoechea de Jorge, E., Griffin, G., Harris, C.L., Holers, V.M., Johnson, S., Lavin, P.J., Medjeral-Thomas, N., Morgan, B.P., Nast, C.C., Noel, L.H., Peters, D.K., Rodriguez de Cordoba, S., Servais, A., Sethi, S., Song, W.C., Tamburini, P., Thurman, J.M., Zavros, M., and Cook, H.T. 2013. C3 Glomerulopathy: consensus report. Kidney Intl. 84:1079-1089. PMCID:PMC3842953

Holers, V.M. 2014. Complement and its receptors: new insights into human disease. Ann. Rev. Immunol. 32:433-459. PMID:24499275

Kraus, D.M., Elliott, G.S., Chute, H., Horan, T., Pfenninger, K.H., Sanford, S.D., Foster, S., Scully, S., Welcher, A.A. and Holers, V.M. 2006. Identification of a novel multiple domain complement regulatory proteins highly expressed in the central nervous system and epithelial tissues. J. Immunol. 176:4419-4430.

Demoruelle, M.K., Deane, K.D., and Holers, V.M. 2014. When and where does inflammation begin in rheumatoid arthritis? Curr. Opin. Rheum. 26:64-71. PMID:24247116

Thurman, J.M., Ljubanovic, D., Royer, P.A., Kraus, D.M., Molina, H., Barry, N.P., Proctor, G., Levi, M., and Holers, V.M. 2006. Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion. J. Clin. Invest. 116:357-368.

Leinhase, I., Schmidt, O.I., Thurman, J.M., Rozanski, M., Scheffler, A., John, T., Smith, W.R., Holers, V.M., and Stahel, P.F. 2006. Pharmacological complement inhibition at the C3 convertase level induces neuroprotective intracerebral gene expression and decreases neurological impairment after traumatic brain injury. Exp. Neurol. 199:454-463.

Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Liu S, Parks CG, Wright NC, Moreland LW. Determinants of mortality among postmenopausal women in the women's health initiative who report rheumatoid arthritis. Arthritis Rheumatol. 2014 Mar;66(3):497-507. PubMed PMID: 24574208

Leinhase, I., Holers, V.M., Thurman, J.M., Harhausen, D., Schmidt, O.I., Pietzcker, M., Taha, M.E., Rittirsch, D., Huber-Lang, M., Smith, W.R., Ward, P.A., and Stahel, P.F. 2006. Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation. BMC Neurosci. 7:55.

Banda, N.K., Mehta, G., Kjaer, T.R., Takahashi, M., Schaack, J., Morrison, T.E., Thiel, S., Arend, W.P., and Holers, V.M. 2014. Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression. J. Immunol. 193:2455-2468. PMCID: PMC4134985

Mikuls, T.R., Holers, V.M., Parrish, L.A., Alarcon, G.S., Conn, D.L., Gilkeson, G., Smith, E.A., Kamen, D.L., Jonas, B.L., Callahan, L., Howard, G., Moreland, L.W., and Bridges, Jr., S.L. 2006. Diagnostic utility of anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor (RF) in African Americans with early onset rheumatoid arthritis: results from the CLEAR registry. Arth. Rheum. 154:3057-3059.

Kuller, L.H., Mackey, R.H., Walitt, B.T., Deane, K.D., Holers, V.M., Robinson, W.H., Sokolove, J., Chang, Y., and Moreland, L.W. 2014. Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation. Am. J. Epidemiol. 179:917-926. PMCID: PMC3969537

Banda, N.K., Thurman, J.M., Kraus, D.M., Wood, A., Carroll, M.C., Arend, W.P., and Holers, V.M. 2006. Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis. J. Immunol. 177:1904-1912.

Schepers, A., de Vries, M.R., van Leuven, C.J., Grimbergen, J.M., Holers, V.M., Daha, M.R., van Bockel, J.H., and Quaz, P.H.A. 2006. Inhibition of complement component C3 reduces intimal hyperplasia in apolipoprotein E3-Leiden transgenic mice. Circulation 114:2831-2838.

Asokan, R., Hua, J., Young, K.A., Gould, H.J., Hannan, J.P., Kraus, D.M., Szakonyi, G., Grundy, G.J., Chen, X.S., Crow, M.K., and Holers, V.M. 2006. Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for interferon-alpha: a potential role in systemic lupus erythematosus. J. Immunol. 177:383-394.

Gilbert, H.E., Asokan, R., Holers, V.M., and Perkins, S.J. 2006. The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions. J. Mol. Biol. 362:1132-1147.

Cataland, S.R., Holers, V.M., Geyer, S., Yang, S., and Wu, H.M. 2014. Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP. Blood 123:3733-3738 PMID: 24695849

Young, K.A., Terrell, D.R., Guthridge, J.M., Kamen, D.L., Gilkeson, G.S., Karp, D.R., Ishimori, M.L., Weisman, M.H., Holers, V.M., Harley, J.B., Norris, J.M., and James, J.A. 2014. Smoking is not associated with autoantibody production in systemic lupus erythematosus patients, unaffected first-degree relatives, nor healthy controls. Lupus 23:360-369, 2014 PMCID

Neher, M.D., Rich, M.C, Keene, C.N., Weckbach, S., Bolden, A.L., Losacco, J.T., Patane, J., Flierl, M.A., Kulik, L., Holers, V.M., and Stahel, P.F. Deficiency of complement receptors CR2/CR1 in Cr2-/- mice reduces the extent of secondary brain damage after closed head injury. J. Neuroinflammation 11:95, 2014 PMCID: PMC4050415

Yui, J., Holers, V.M., Yang, S., Wu, H.M., and Cataland, S.R. Clinical utility of complement biomarkers in the diagnosis and treatment of acute thrombotic microangiopathies. Brit. J. of Haematology167:697-698, 2014 PMID: 25040791

Holers, V.M. 2014. Complement and its receptors: new insights into human disease. Ann. Rev. Immunol. 32:433-459. PMID:24499275

Szakonyi, G., Klein, M., Hannan, J.P., Young, K.A., Ma, R., Holers, V.M., and Chen, X. 2006. Structure of the major envelope glycoprotein gp350 of Epstein-Barr virus. Nature Struc. and Molec. Biol. 13:996-1001.

Holers, V.M. 2014. When and where does inflammation begin in rheumatoid arthritis? Curr. Opin. Rheum. 26:64-71. PMCID: PMC4033623

Bhatia, S.S., Majka, D.S., Kittelson, J.M., Parrish, L.A., Ferucci, E.D., Deane, K.D., Arend, W.P., Rewers, M., Holers, V.M., and Norris, J.M. 2006. Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis. Ann. Rheum. Dis. 66:267-269.

Girardi, G., Yarilin, D., Thurman, J.M., Holers, V.M., and Salmon, J.E. 2006. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J. Exp. Med. 203:2165-2175.

Thurman, J.M., and Holers, V. M. 2006. The central role of the alternative complement pathway in human disease. J. Immunol. 176:1305-1310.

Liang MH, Couto MC, Duarte CC, Gall V, White P, Naides S, Schumacher HR Jr, Hwang AS, Holers VM, Deane KD, Gupta S, Ho IC, Finckh A, Kopec J, Choi CB, Sayre EC. An Internet-based technique for the identification of persons with symptoms of inflammatory polyarthritis of less than 12 weeks. Clin Rheumatol. 2015 Mar;34(3):465-70. PubMed PMID: 25339123

Cruickshank MN, Dods J, Taylor RL, Karimi M, Fenwick EJ, Quail EA, Rea AJ, Holers VM, Abraham LJ, Ulgiati D. Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility. Int J Biochem Cell Biol. 2015 Jul;64:107-19. PubMed PMID: 25817480

Atkinson C, Qiao F, Yang X, Zhu P, Reaves N, Kulik L, Goddard M, Holers VM, Tomlinson S. Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury. Circulation. 2015 Mar 31;131(13):1171-80. PubMed PMID: 25825397

Mehta G, Scheinman RI, Holers VM, Banda NK. A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA. J Immunol. 2015 Jun 1;194(11):5446-54. PubMed PMID: 25917104

Thurman, J.M., and Holers, V. M. 2006. Complement deficient mice as model systems for kidney diseases in Complement and Kidney Disease (Ed., P. Zipfel), Birkhauer-Verlag, Basel, Switzerland. p. 49-63.

Holers, V. M. 2006. Viewpoint: Are anti-cyclic citrullinated peptide antibodies pathogenic in rheumatoid arthritis? Nature Clin. Prac. Rheum. 2:400-401.

Kulik L, Hewitt FB, Willis VC, Rodriguez R, Tomlinson S, Holers VM. A new mouse anti-mouse complement receptor type 2 and 1 (CR2/CR1) monoclonal antibody as a tool to study receptor involvement in chronic models of immune responses and disease. Mol Immunol. 2015 Feb;63(2):479-88. PubMed PMID: 25457881

Majka, D.S., and Holers, V. M. 2006. Cigarette smoking and the risk of systemic lupus erythematosus and rheumatoid arthritis. Ann. Rheum. Dis. 65L561-563.

Thorgersen, E.B., Ghebremariam, Y.T., Thurman, J.M., Fung, M., Nielsen, E.W., Holers, V.M., Kotwal, G.J., and Mollnes, T.E. 2007. Candidate inhibitors of porcine complement. Mol. Immunol. 44:1827-1834.

Young, K.A., Parrish, L., Zerbe, G. Rewers, M., Deane, K.D., Holers, V.M., and Norris, J.M. 2007. Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy pediatric population. Ann. Rheum. Dis. 66:179-183.

Kulik, L, Marchbank, K.J., Lyubchenko, T., Kuhn, K.K., Liubchenko, G.A., Haluszczak, C., Gibson, M.G., Boackle, S.A., and Holers, V.M. 2007. Intrinsic B cell hypo-responsiveness results from premature expression of human CR2/CD21 during B cell development. Eur. J. Immunol. 37:623-633.

Ho, J., Moir, S., Kulik, L., Malaspina, A., Donoghue, E.T., Miller, N.J., Chun, T.-W., Fauci, A.S., and Holers, V.M. 2007. Essential role for CD21 in the establishment of an extracellular HIV reservoir in lymphoid tissues. J. Immunol. 178:6968-6974.

Looney, R.J., Diamond, B., Holers, V.M., Levesque, M., Moreland, L. Nahm, M., and St. Clair, W. 2007. Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases. Clin. Immunol. 123:235-243.

Mackey RH, Kuller LH, Deane KD, Walitt BT, Chang YF, Holers VM, Robinson WH, Tracy RP, Hlatky MA, Eaton CB, Liu S, Freiberg MS, Talabi MB, Schelbert EB, Moreland LW. Rheumatoid Arthritis, Anti-Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative. Arthritis Rheumatol. 2015 Sep;67(9):2311-22. PubMed PMID: 25988241

Gan RW, Trouw LA, Shi J, Toes RE, Huizinga TW, Demoruelle MK, Kolfenbach JR, Zerbe GO, Deane KD, Edison JD, Gilliland WR, Norris JM, Holers VM. Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis. J Rheumatol. 2015 Apr;42(4):572-9. PubMed PMID: 25593232

Panzer SE, Laskowski J, Renner B, Kulik L, Ljubanovic D, Huber KM, Zhong W, Pickering MC, Holers VM, Thurman JM. IgM exacerbates glomerular disease progression in complement-induced glomerulopathy. Kidney Int. 2015 Sep;88(3):528-37. PubMed PMID: 25945405

Inturi S, Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D. Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake. ACS Nano. 2015 Nov 24;9(11):10758-68. PubMed PMID: 26488074

Mihai, S., Chiriac, M.T., Takahashi, K., Thurman, J.M., Holers, V.M., Zillikens, D., Botto, M., and Sitaru, C. 2007. The alternative pathway of complement activation is critical for blister formation in experimental epidermolysis acquisita. J. Immunol. 178:6514-6521.

Renner B, Tong HH, Laskowski J, Jonscher K, Goetz L, Woolaver R, Hannan J, Li YX, Hourcade D, Pickering MC, Holers VM, Thurman JM. Annexin A2 Enhances Complement Activation by Inhibiting Factor H. J Immunol. 2016 Feb 1;196(3):1355-65. PubMed PMID: 26729803

Gan RW, Young KA, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Clare-Salzler MJ, Deane KD, Holers VM, Norris JM. Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study. Rheumatology (Oxford). 2016 Feb;55(2):367-76. PubMed PMID: 26370400

Thurman, J.M., Lenderink, A.M., Royer, P.A., Coleman, K.E., Zhou, J., Lambris, J.D., Nemenoff, R.A., Quigg, R.J., and Holers, V.M. 2007. C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ischemia/reperfusion. J. Immunol. 178:1819-1828.

Lyubchenko, T., Dal Porto, J., Holers, V.M., and Cambier, J.C. 2007. C3d-linked antigens break B cell anergy. J. Immunol. 179:2695-2699.

Lynch AM, Wagner BD, Deterding RR, Giclas PC, Gibbs RS, Janoff EN, Holers VM, Santoro NF. The relationship of circulating proteins in early pregnancy with preterm birth. Am J Obstet Gynecol. 2016 Apr;214(4):517.e1-8. PubMed PMID: 26576488

Rich MC, Keene CN, Neher MD, Johnson K, Yu ZX, Ganivet A, Holers VM, Stahel PF. Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains. Neurosci Lett. 2016 Mar 23;617:188-94. PubMed PMID: 26892188

Banda, N.K., Takahashi, K. Wood, A.K., Holers, V.M., and Arend, W.P. 2007. Pathogenic complement activation in collagen antibody- induced arthritis in mice requires amplification by the alternative pathway. J. Immunol. 179:4101-4109.

Lynch AM, Wagner BD, Giclas PC, West NA, Gibbs RS, Holers VM. The Relationship of Longitudinal Levels of Complement Bb During Pregnancy with Preeclampsia. Am J Reprod Immunol. 2016 Feb;75(2):104-11. PubMed PMID: 26510395

Twohig, J., Kulik, L., Haluszczak, C., Reuter, J., Rossbach, A., Bull, M., Holers, V.M., and Marchbank, K.J. 2007. Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3. Mol. Immunol. 44:3434-3444.

Lenderink, A.M., Ljubanovic, D., Holers, V.M., and Thurman, J.M. 2007. The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy. Am. J. Physiol. – Renal Physiol. 293: F555-564.

Young, K.A., Chen, X.S., Holers, V.M., and Hannan, J.P. 2007. Isolating the Epstein-Barr virus (EBV) gp350/220 binding site on complement receptor type 2 (CR2/CD21). J. Biol. Chem. 282:36614-36625.

Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan JP, Ljubanovic D, Ruseva MM, Borza DB, Antonioli AH, Pickering MC, Holers VM, Thurman JM. Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury. Kidney Int. 2016 Jul;90(1):109-22. PubMed PMID: 27165610

Kinslow JD, Blum LK, Deane KD, Demoruelle MK, Okamoto Y, Parish MC, Kongpachith S, Lahey LJ, Norris JM, Robinson WH, Holers VM. Elevated IgA Plasmablast Levels in Subjects at Risk of Developing Rheumatoid Arthritis. Arthritis Rheumatol. 2016 Oct;68(10):2372-83. PubMed PMID: 27273876

Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D. Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking. Front Immunol. 2016 Oct 10;7:418. PubMed PMID: 27777575

Song, H., Qiao, F., Atkinson, C., Holers, V.M., and Tomlinson, S. 2007. A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice. J. Immunol. 179:7860-7867.

Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016 Oct 20;1(17):e90045. PubMed PMID: 27777982

Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. PLoS One. 2016 Nov 4;11(11):e0166200. PubMed PMID: 27814381

Banda NK, Acharya S, Scheinman RI, Mehta G, Coulombe M, Takahashi M, Sekine H, Thiel S, Fujita T, Holers VM. Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing. J Immunol. 2016 Nov 1;197(9):3680-3694. PubMed PMID: 27707997

Leinhase, I, Rozanski, M, Harhausen, D. Thurman, J.M, Schmidt, O.I., Hossini, A.M., Taha, M.E., Rittersch, D., Ward, P.A., Holers, V.M., and Stahel, P.F. 2007. J. Neuroinflamm. 4:13.

Karp, D. R., and Holers, V. M., 2007. Complement in health and disease in Cecil Textbook of Medicine (Ed. L. Goldman and D. Ausiello), W. B. Saunders, Inc., Orlando, FL. p. 47:282-288.

Holers, V.M., and Kulik, L. 2007. Complement receptor 2, natural antibodies and innate immunity: inter-relationships in B cell selection and activation. Mol. Immunol. 44:64-72.

Willis VC, Banda NK, Cordova KN, Chandra PE, Robinson WH, Cooper DC, Lugo D, Mehta G, Taylor S, Tak PP, Prinjha RK, Lewis HD, Holers VM. Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis. Clin Exp Immunol. 2017 May;188(2):263-274. PubMed PMID: 28128853

Holers, V. M. 2007. Antibodies to Citrullinated Proteins: Pathogenic and Diagnostic Significance. Curr. Rheum. Reports. 9:396-400.

Gan RW, Demoruelle MK, Deane KD, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Fingerlin TE, Zerbe GO, Clare-Salzler MJ, Holers VM, Norris JM. Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis. Ann Rheum Dis. 2017 Jan;76(1):147-152. PubMed PMID: 27190099

Clark, A., Weymann, A., Hartman, E., Turmelle, Y., Carroll, M., Thurman, J., Holers, V.M., Hourcade, D.E., and Rudnick, D.A. 2008. Evidence for nontraditional activation of complement factor 3 during liver regeneration. Mol. Immunol. 45:3125-3132.

Demoruelle MK, Harrall KK, Ho L, Purmalek MM, Seto NL, Rothfuss HM, Weisman MH, Solomon JJ, Fischer A, Okamoto Y, Kelmenson LB, Parish MC, Feser M, Fleischer C, Anderson C, Mahler M, Norris JM, Kaplan MJ, Cherrington BD, Holers VM, Deane KD. Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients. Arthritis Rheumatol. 2017 Jun;69(6):1165-1175. PubMed PMID: 28182854

Banda, N.K., Wood, A.K., Takahashi, K., Levitt, B., Rudd, P.M., Royle, L., Abrahams, J.L., Stahl, G.L., Holers, V.M., and Arend, W.P. 2008. Initiation of the alternative pathway of complement by immune complexes is dependent on N-glycans in IgG antibodies. Arth. Rheum. 58:3081-3089.

Zaiss, A.K., Cotter, M.J., White, L.R., Clark, S.A., Wong, N.C.W., Holers, V.M., Bartlett, J.S., and Muruve, D.A. 2008. Complement is an essential component of the immune response to adeno-associated virus vectors. J. Virology 82:2727-2740.

Birru Talabi M, Mackey RH, Kuller LH, Dorman JS, Deane KD, Robinson WH, Walitt BT, Chang Y, Holers VM, Liu S, Moreland LW. Human Leukocyte Antigen Shared Epitope and Inflammation, Cardiovascular Disease, Cancer, and Mortality Among Postmenopausal Women in the Women's Health Initiative Rheumatoid Arthritis Study. Am J Epidemiol. 2017 Jul 15;186(2):245-254. PubMed PMID: 28459968

Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y, Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H, Holers VM. Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2. J Immunol. 2017 Sep 1;199(5):1835-1845. PubMed PMID: 28739878

Wang G, Griffin JI, Inturi S, Brenneman B, Banda NK, Holers VM, Moghimi SM, Simberg D. In Vitro and In Vivo Differences in Murine Third Complement Component (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms. Front Immunol. 2017;8:151. PubMed PMID: 28239384

Gan RW, Bemis EA, Demoruelle MK, Striebich CC, Brake S, Feser ML, Moss L, Clare-Salzler M, Holers VM, Deane KD, Norris JM. The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population. Rheumatology (Oxford). 2017 Dec 1;56(12):2229-2236. PubMed PMID: 29029330

Mikuls, T.R., Hughes, L.B., Westfall, A.O., Holers, V.M., Parrish, L., van der Heijde, D., van Everdingen, M., Alarcon, G.S., Conn, D.L., Jonas, B., Callahan, L.F., Smith, E.A., Gilkeson, G., Howard, G., Moreland, L.W., and Bridges, L. 2008. Cigarette smoking, disease severity and autoantibody expression in African Americans with recent-onset rheumatoid arthritis. Ann. Rheum. Dis. 67:1529-1534.

Kuhn, K.A., Cozine, C.L., Tomooka, B., Robinson, W.H., and Holers, V.M. 2008. Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens. Mol. Immunol. 45:2802-2819.

273. Narang, A., Qiao, F., Atkinson, C., Zhu, H., Yang, X., Kulik, L., Holers, V.M., and Tomlinson, S. 2017. Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury drive secondary injury by activating complement. J. Neuroinflam. doi:10.1186/s12974-017-0894-6. PMCID: PMC5477255

275. Chen, F., Wang, G., Griffin, J.I., Brenneman, B., Banda, N.K., Holers, V.M., Backos, D.S., Wu, L., Moghimi, S.M., and Simberg, D.. 2017. Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo. Nat. Nanotechnol. 12:387-393. PMCID: PMC5617637

72. Thurman, J.M., Frazer-Abel, A., and Holers, V.M. 2017. The evolving landscape for complement therapeutics in rheumatic and autoimmune diseases. Arth. Rheum. 69:2102-2113. PMCID: PMC5659941

73. Deane, K.D., Striebich, C.C., and Holers, V.M. 2017. Editorial: Prevention of rheumatoid arthritis: Now is the time, but how to proceed? Arth. Rheum. 69:873-877. PMCID: PMC5406258

Huang, Y., Qiao, F., Atkinson, C., Holers, V.M., and Tomlinson, S. 2008. A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury. J. Immunol. 181:8068-8076.

Li, K. Okemefuna, A.I., Gor, J., Hannan, J.P., Asokan, R. Holers, V.M., and Perkins, S.J. 2008. Solution structure of the complex formed between human complement C3d and full-length complement receptor type 2. J. Mol. Biol. 384:137-150.

Young, K.A., Herbert, A.P., Barlow, P.N., Holers, V.M., and Hannan, J.P. 2008. Molecular basis for the interaction between complement receptor 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350. J. Virol. 82:11217-11227.

Lynch, A.M., Gibbs, R.S., Murphy, J.R., Byers, T., Neville, M.C., Giclas, P.C., Salmon, J.E., Van Hecke, T.M. and Holers, V.M. 2008. Complement activation fragment Bb in early pregnancy and spontaneous preterm birth. Am. J. Obst. And Gyn. 199:354.e108.

Holers, V.M., and Salmon, J.E. 2008. Complement and pregnancy loss in Contemporary Targeted Therapies in Rheumatology (Ed, J.S. Smolen and P.E. Lipsky), Informa Healthcare, Abington, UK.

Antonioli, A.H., White, J., Crawford, F., Renner, B., Marchbank, K.J., Hannan, J.P., Thurman, J.M., Marrack, P., and Holers, V.M. 2018. Modulation of the alternative pathway of complement by murine factor H-related proteins. J. Immunol. 200:316-326. PMCID: PMC5736413

He, Y.G., Pappworth, I.Y., Rossbach, A., Paulin, J., Mavimba, T., Hayes, C., Kulik, L., Holers, V.M., Knight, A.M., and Marchbank, K.J. 2018. A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice. Immunobiology 223:125-134. PMCID: PMC5849677

Mihai, S., Hirose, M., Wang, Y., Thurman, J.M., Holers, V.M., Morgan, B.P., Kohl, J., Zillikens, D., Ludwig, R.J., and Nimmerjahn, F. 2018. Specific inhibition of complement activation significantly ameliorates autoimmune blistering disease in mice. Front. Immunol. 9:535. PMCID: PMC5865061

Demoruelle, M.K., Bowers, E., Lahey, L.J., Sokolove, J., Purmalek, M., Seto, N.L., Weisman, M.H., Norris, J.M., Kaplan, M.J., Holers, V.M., Robinson, W.H., and Deane, K.D. 2018. Antibody responses to citrullinated and noncitrullinated antigens in the sputum of subjects with rheumatoid arthritis and subjects at risk for development of rheumatoid arthritis. Arth. Rheum. 70:516-527. PMCID: PMC5876113

Goetz, L., Laskowski, J., Renner, B., Pickering, M.C., Kulik, L., Klawitter, J., Stites, E., Christians, U., van der Vlag, J., Ravichandran, K., Holers, V.M., and Thurman, J.M. 2018. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. Eur. J. Immunol. 48:791-802. PMCID: PMC5992014

Okamoto, T., Mathai, S.K., Hennessy, C.E., Hancock, L.A., Walts, A.D., Stefanski, A.L., Brown, K.K., Lynch, D.A., Cosgrove, G.P., Groshong, S.D., Cool, C.D., Schwarz, M.I., Banda, N.K., Thurman, J.M., Yang, I.V., Holers, V.M., and Schwartz, D.A. 2018. The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis. Am. J. Physiol. - Lung Cell. & Mol. Physiol. 315:L1-L10. PMCID: PMC6087895

Hughes-Austin, J.M., Deane, K.D., Giles, J.T., Derber, L.A., Zerbe, G.O., Dabelea, D.M., Sokolove, J., Robinson, W.H., Holers, V.M., and Norris, J.M. 2018. Plasma adiponectin levels are associated with circulating inflammatory cytokines in autoantibody positive first-degree relatives of rheumatoid arthritis patients. PLoS ONE 13(6):e0199578. PMCID: PMC6016921

Donlin, L.T, Rao, D.A., Wei, K., Slowikowski, K., McGeachy, M.J., Turner, J.D., Meednu, N., Mizoguchi, F., Gutierrez-Arcelus, M., Lieb, D.J., Keegan, J., Muskat, K., Hillman, J., Rozo, C., Ricker, E., Eisenhaure, T.M., Li, S., Browne, E.P., Chicoine, A., Sutherby, D., Noma, A., Accelerating Medicines Partnership RA/SLE Network, Nusbaum, C., Kelly, S., Pernis, A.B., Ivashkiv, L.B., Goodman, S.M., Robinson, W.H., Utz, P.J., Lederer, J.A., Gravallese, E.M., Boyce, B.F., Hacohen, N., Pitzalis, C., Gregersen, P.K., Firestein, G.S., Raychaudhuri, S., Moreland, L.W., Holers, V.M., Bykerk, V.P., Filer, A., Boyle, D.L., Brenner, M.B., and Anolik, J.H. 2018. Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arth. Res. Ther. 20:139. PMCID: PMC6042350

Holers, V. M. 2008. Complement in Rheumatoid Arthritis. In Rheumatoid Arthritis (Ed, M.C. Hochberg, A.J. Silman, J.S. Smolen, M.H. Weisman and M.E. Weinblatt), Mosby, Inc. St. Louis, MO.

Verheul, M.K., Bohringer, S., van Delft, M.A.M., Jones, J.D., Rigby, W.F.C., Gan, R.W., Holers, V.M., Edison, J.D., Deane, K.D., Janssen, K.M.J., Westra, J., Brink, M., Rantapaa-Dahlqvist, S., Huizinga, T.W.J., van der Helm-van Mil, A.H.M., van der Woude, D., Toes, R.E.M, and Trouw, L.A. 2018. Triple positivity for three autoantibodies, ACPA, RF and anti-CarP antibodies is highly specific for rheumatoid arthritis: implications for very early identification of individuals at risk to develop rheumatoid arthritis. Arth. Rheum. 70:1721-1731. PMID: 29781231

Banda, N.K. Desai, D., Scheinman, R.I., Pihl, R., Sekine, H., Fujita, T., Sharma, V., Hansen, A.G., Garred, P., Thiel, S., Borodovsky, A., and Holers, V.M. 2018. Targeting of liver mannan-binding lectin-associated serine protease-3 with RNA interference ameliorates disease in a mouse model of rheumatoid arthritis. ImmunoHorizons 2:274-295. PMCID: PMC6220895

Lingampalli, N., Sokolove, J., Lahey, L.J., Edison, J.D., Gilliland, W.R., Holers, V.M., Deane, K.D., and Robinson, W.H. 2018. Combination of anti-citrullinated protein antibodies and rheumatoid factor is associated with increased systemic inflammatory mediators and more rapid progression from preclinical to clinical rheumatoid arthritis. Clinical Immunology 195:119-126. PMID: 29842946

Jalal, D., Renner, B., Laskowski, J., Stites, E., Cooper, J., Valente, K., You, Z., Perrenoud, L., Le Quintrec, M., Muhamed, I., Christians, U., Klawitter, J., Lindorfer, M.A., Taylor, R.P., Holers, V.M., and Thurman, J.M. 2018. Endothelial microparticles and systemic complement activation in patients with chronic kidney disease. J. Am. Heart Assoc. 7(14): e007818. PMCID: PMC6064828

Holers, V. M. 2008. The spectrum of complement alternative pathway mediated diseases. Immunol. Rev. 223:300-316.

Holers, V.M., and Banda, N.K. 2018. Complement in the initiation and evolution of rheumatoid arthritis. Front. Immunol. 9:1057. PMCID: PMC5985368

Kulik, L., Fleming, S.D., Moratz, C., Reuter, J.W., Novikov, A., Chen, K., Andrews, K.A., Markaryan, A., Quigg, R.J., Silverman, G.J.,Tsokos, G.C. and Holers, V.M. 2009. Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury. J. Immunol. 182:5363-5373.

Lyubchenko, T., Nielsen, J.P., Miller, S.M., Liubchenko, G.A., and Holers, V.M. 2009. Role of initial protein phosphorylation events and localized release-activated calcium influx in B cell antigen receptor signaling. J. Leuk. Biol. 85:298-309.

Tenner, A.J., Atkinson, J.P., and Holers, V.M. 2018. Preface to the special issue for the 27th International Complement Workshop. Mol. Immunol. 102:1-2. PMID: 30060927

Holers, V.M., Demoruelle, M.K., Kuhn, K.A., Buckner, J.H., Robinson, W.H., Okamoto, Y., Norris, J.M., and Deane, K.D. 2018. Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction. Nature Reviews Rheumatology 14:542-557. PMID: 30111803

Kovacs, J.M., Hannan, J.P., Eisenmesser, E.Z., and Holers, V.M. 2009. Mapping of he C3d ligand binding site on complement receptor 2 (CR2/CD21) using nuclear magnetic resonance and chemical shift analysis. J. Biol. Chem. 284:9513-9520

Mikuls, T.R., Payne, J.B., Reinhardt, R.A, Thiele, G.M., Maziarz, E., Cannella, A.C., Holers, V.M., Kuhn, K.A., and O’Dell, J.R. 2009. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int. Immunopharm. 9:38-42.

Twohig, J.P., Pappworth, I.Y., Kulik, L., Bull, M., Holers, V.M., Wang, E.C.Y., and Marchbank, K.J. 2009. Defective B cell ontogeny and immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Mol. Immunol. 46:2002-2013.

Feser, M., Derber, L.A., Deane, K.D., Lezotte, D.C., Weisman, M.H., Buckner, J.H., Mikuls, T., O’Dell, J.R., Gregersen, P.K., Holers, V.M., and Norris, J.M. 2009. Plasma 25,OH vitamin D levels are not associated with rheumatoid arthritis-related autoantibodies in individuals at elevated risk for rheumatoid arthritis. J. Rheum. 36:943-946.

Bemis, E.A., Norris, J.M., Seifert, J., Frazer-Abel, A., Okamoto, Y., Feser, M.L., Demoruelle, M.K., Deane, K.D., Banda, N.K., and Holers, V.M. 2019. Complement and its environmental determinants in the progression of human rheumatoid arthritis. Mol. Immunol. 112:256-265. PMID: 31207549

Lynch, A.M., Mandava, N., Patnaik, J.L., Frazer-Abel, A.A., Wagner, B.D., Palestine, A.G., Mathias, M.T., Siringo, F.S., Cathcart, J.N., and Holers, V.M. 2019. Systemic activation of the complement system in patients with advanced age-related macular degeneration. Eur. J. Ophthal. 1120672119857896. PMID: 31203676

Hernandez, G., Mills, T.S., Rabe, J.L., Chavez, J.S., Kuldanek, S., Kirkpatrick, G., Noetzli, L., Jubair, W.K., Zanche., M., Meyers, J.R., Stevens, B.M., Fleenor, C.J., Adane, B., Dinarello, C.A., Ashton, J., Jordan, C.T., Di Paola, J., Hagman, J.R., Holers, V.M., Kuhn, K.A., and Pietras, E.M. 2019. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica May 17. PMID: 31101752

Berens, H.M., Polinski, K.J., Mikuls, T.R., Khatter, S., August, J., Visser, A., Mahler, M., Weisman, M., O'Dell, J.R., Keating, R.M., Buckner, J.H., Gregersen, P.K., Norris, J.M., Holers, V.M., Deane, K.D., and Demoruelle, M.K. 2019. Anti-CCP3.1 and anti-CCP-IgA are associated with increasing age in individuals without rheumatoid arthritis. J. Rheum. 46: 1556-1559. PMCID: PMC6800826

Zhang, F., Wei, K., Slowikowski, K., Fonseka, C.Y., Rao, D.A., Kelly, S., Goodman, S.M., Tabechian, D., Hughes, L.B., Salomon-Escoto, K., Watts, G.F.M., Jonsson, A.H., Rangel-Moreno, J., Meednu, N., Rozo, C., Apruzzese, W., Eisenhaure, T., Lieb, D.J., Boyle, D.L., Mandelin, A.M., Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Boyce, B.F., DiCarlo, E., Gravallese, E.M., Gregersen, P.K., Moreland, L., Firestein, G.S., Hacohen, N., Nusbaum, C., Lederer, J.A., Perlman, H., Pitzalis, C., Filer, A., Holers, V.M., Bykerk, V.P., Donlin, L.T., Anolik, J., Brenner, M.B., and Raychaudhuri, S. 2019. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nature Immunol. 20:928-942. PMCID: PMC6602051

Gifford, G., Vu, V.P., Banda, N.K., Holers ,V.M., Wang, G., Groman, E.V., Backos, D., Scheinman, R., Moghimi, S.M., and Simberg, D. 2019. Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55. J. Control. Release. 302:181-189. PMCID: PMC6684249

Pappworth, I.Y., Kulik, L., Haluszczab, C., Reuter, J.W., Holers, V.M., and Marchbank, K.J. 2009. Increased B cell delection and significantly reducted autoantibody titre due to premature expression of human complement receptor type 2 (CR2, CD21). Mol. Immunol. 46:1042-1049.

James, J.A., Chen, H., Young, K.A., Bemis, E.A., Seifert, J., Bourn, R.L., Deane, K.D., Demoruelle, M.K., Feser, M., O'Dell, J.R., Weisman, M.H., Keating, R.M., Gaffney, P.M., Kelly, J.A., Langefeld, C.D., Harley, J.B., Robinson, W., Hafler, D.A., O'Connor, K.C., Buckner, J., Guthridge, J.M., Norris, J.M., and Holers, V.M. 2019. Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients. EBioMedicine. 42:76-85. PMCID: PMC6491794

Gregersen, P.K., Amos, C.I., Lee, A.T., Lu, E., Remmers,E.F., Korman, B.D., Kastner, D.L., Seldin, M.F., Criswell, L.A., Plenge, R.M., Holers, V.M., Mikuls, T., Sokka, T., Moreland, L.W., Bridges, S.L., Begovich, A., and Siminovitch, K. 2009. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nature Genetics 41:820-823.

Stathopoulos, P., Chastre, A., Waters, P., Irani, S., Fichtner, M.L., Benotti, E.S., Guthridge, J.M., Seifert, J., Nowak, R.J., Buckner, J.H., Holers, V.M., James, J.A., Hafler, D.A., and O'Connor, K.C. 2019. Autoantibodies against neurologic antigens in nonneurologic autoimmunity. J. Immunol. 202:2210-2219. PMCID: PMC6452031

Kelmenson, L.B., Wagner, B.D., McNair, B.K., Frazer-Abel, A., Demoruelle, M.K., Bergstedt, D.T., Feser, M.L., Moss, L.K., Parish, M.C., Mewshaw, E.A., Mikuls, T.R., Edison, J.D., Holers, V.M., and Deane, K.D. 2019. Timing of elevations of autoantibody isotypes in rheumatoid arthritis prior to disease diagnosis. Arth. Rheum. Aug 29. doi: 10.1002/art.41091. PMID: 31464042

James, J.A., Guthridge, J.M., Chen, H., Lu, R., Bourn, R.L., Bean, K., Munroe, M.E., Smith, M., Chakravarty, E., Baer, A.N., Noaiseh, G., Parke, A., Boyle, K., Keyes-Elstein, L., Coca, A., Utset, T., Genovese, M.C., Pascual, V., Utz, P.J., Holers, V.M., Deane, K.D., Sivils, K.L., Aberle, T., Wallace, D.J., McNamara, J., Franchimont, N., and St Clair, E.W. 2019. Unique Sjögren's syndrome patient subsets defined by molecular features. Rheumatology doi: 10.1093/rheumatology/kez335. PMID: 31497844

Frid, M.G., McKeon, B.A., Thurman, J.M., Maron, B.A., Li, M., Zhang, H., Kumar, S., Sullivan, T., Laskowsky, J., Fini, M.A., Hu, S., Tuder, R.M., Gandjeva, A., Wilkins, M.R., Rhodes, C.J., Ghataorhe, P., Leopold, J.A., Wang, R.S., Holers, V.M,, and Stenmark, K.R. 2019. Immunoglobulin-driven complement activation regulates pro-inflammatory remodeling in pulmonary hypertension. Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201903-0591OC. PMID: 31545648

Mastellos, D.C., Blom, A.M., Connolly, E.S., Daha, M.R., Geisbrecht, B.V., Ghebrehiwet, B., Gros, P., Hajishengallis, G., Holers, V.M,, Huber-Lang, M., Kinoshita, T., Mollnes, T.E., Montgomery, R.A., Morgan, B.P., Nilsson, B., Pio, R., Ricklin, D., Risitano, A.M., Taylor, R.P., Mantovani, A., Ioannidis, J.P.A., and Lambris, J.D. 2019. ‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development. Nat. Immunol. doi: 10.1038/s41590-019-0503-1. PMID: 31562490

Polinski, K.J., Bemis, E.A., Feser, M., Seifert, J., Demoruelle, M.K., Striebich, C.C., Brake, S., O'Dell, J.R., Mikuls, T.R., Weisman, M.H., Gregersen, P.K., Keating, R.M., Buckner, J., Nicassio, P., Holers, V.M., Deane, K.D., and Norris, J.M. 2019. Perceived stress and inflammatory arthritis: a prospective investigation in the Studies of the Etiologies of Rheumatoid Arthritis (SERA) cohort. Arth. Care Res. doi: 10.1002/acr.24085. PMID: 31600025

Xu, X., Hsu, H.-C., Chen, J., Grizzle, W.E., Chatham, W.W., Stockard, C.R., Wu, Q., Yang, P.A., Holers, V.M., and Mountz, J.D. 2009. Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis. Scand. J. Immunol. 70:309-316.

Ricklin, D., Tzekou, A., Garcia, B.L., Hammel, M., McWhorter, W.J., Sfyroera, G., Wu, Y.Q., Holers, V.M., Herbert, A.P., Barlow, P.M., Geisbrecht, B.V. and Lambris, J.D. 2009. A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. J. Immunol. 183: 2565-2574.

Kolfenbach, J.R., Deane, K.D., Derber, L.A., O”Donnell, C., Weisman, M.H., Buckner, J.H., Gersuk, V.H., Wei, S., Mikuls, T.R., O’Dell, J., Gregersen, P.K., Keating, R.M., Norris, J.M., and Holers, V.M. 2009. A prospective approach to investigating the natural history of pre-clinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA. Arth. Care Res. 61: 1735-1742.

Deane, K.D., Striebich, C., Goldstein, B.L., Derber, L.A., Parish, M.C., Feser, M.L., Hamburger, E.M., Brake, S., Belz, C., Goddard, J., Norris, J.M., Karlson, E.W., and Holers, V.M. 2009. Identification of undiagnosted inflammatory arthritis in a community health fair screen. Arth. Care Res. 61: 1642-1649.

Kulik, L., Laskowski, J., Renner, B., Woolaver, R., Zhang, L., Lyubchenko, T., You, Z., Thurman, J.M., and Holers, V.M. 2019. Targeting the immune complex-bound complement C3d ligand as a novel therapy for lupus. J. Immunol. doi: 10.4049/jimmunol.1900620. PMID: 31732528

Deane, K.D., and Holers, V.M. 2019. The natural history of rheumatoid arthritis. Clin. Therap. May 14. PMID: 31196652

Raza, K., Holers, V.M., and Gerlag, D. 2019. Nomenclature for the phases of the development of rheumatoid arthritis. Clin. Therap. May 03. PMID: 31196657

Holers, V.M. and Trouw, L. 2019; Complement system. Kelly & Firestein’s Texbook of Rheumatology, 11th Edition. Elsevier, Philadelphia, PA.

Slight-Webb, S., Bourn, R.L., Holers, V.M., and James, J.A. 2019. Shared and unique immune alterations in pre-clinical autoimmunity. Curr. Opin. Immunol. doi: 10.1016/j.coi.2019.08.006. PMID: 31557691

300. Frid, M.G., McKeon, B.A., Thurman, J.M., Maron, B.A., Li, M., Zhang, H., Kumar, S., Sullivan, T., Laskowsky, J., Fini, M.A., Hu, S., Tuder, R.M., Gandjeva, A., Wilkins, M.R., Rhodes, C.J., Ghataorhe, P., Leopold, J.A., Wang, R.S., Holers, V.M., and Stenmark, K.R. 2020. Immunoglobulin-driven complement activation regulates pro-inflammatory remodeling in pulmonary hypertension. Am. J. Respir. Crit. Care Med. 201:224-239. PMCID: PMC6961755301.

301. Polinski, K.J., Bemis, E.A., Feser, M., Seifert, J., Demoruelle, M.K., Striebich, C.C., Brake, S., O'Dell, J.R., Mikuls, T.R., Weisman, M.H., Gregersen, P.K., Keating, R.M., Buckner, J., Nicassio, P., Holers, V.M., Deane, K.D., and Norris, J.M. 2020. Perceived stress and inflammatory arthritis: a prospective investigation in the Studies of the Etiologies of Rheumatoid Arthritis (SERA) cohort. Arth. Care Res. 72:1766-1771. PMCID: PMC7145743

302. Lynch, A.M., Mandava, N., Patnaik, J.L., Frazer-Abel, A.A., Wagner, B.D., Palestine, A.G., Mathias, M.T., Siringo, F.S., Cathcart, J.N., and Holers, V.M. 2020. Systemic activation of the complement system in patients with advanced age-related macular degeneration. Eur. J. Ophthal. 30:1061-1068. PMID: 31203676

303. Kelmenson, L.B., Wagner, B.D., McNair, B.K., Frazer-Abel, A., Demoruelle, M.K., Bergstedt, D.T., Feser, M.L., Moss, L.K., Parish, M.C., Mewshaw, E.A., Mikuls, T.R., Edison, J.D., Holers, V.M., and Deane, K.D. 2020. Timing of elevations of autoantibody isotypes in rheumatoid arthritis prior to disease diagnosis. Arth. Rheum. 72:251-261. PMCID: PMC6994340

304. James, J.A., Guthridge, J.M., Chen, H., Lu, R., Bourn, R.L., Bean, K., Munroe, M.E., Smith, M., Chakravarty, E., Baer, A.N., Noaiseh, G., Parke, A., Boyle, K., Keyes-Elstein, L., Coca, A., Utset, T., Genovese, M.C., Pascual, V., Utz, P.J., Holers, V.M., Deane, K.D., Sivils, K.L., Aberle, T., Wallace, D.J., McNamara, J., Franchimont, N., and St. Clair, E.W. 2020. Unique Sjögren's syndrome patient subsets defined by molecular features. Rheumatology 51:860-868. PMCID: PMC7188221

305. Bemis, E.A., Demoruelle, M.K., Seifert, J.A., Polinski, K.J., Weisman, M.H., Buckner, J.H., Gregersen, P.K., Mikuls, T.R., O’Dell, J.R., Keating, R.M., Deane, K.D., Holers, V.M., and Norris, J.M. 2020. Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clinical setting. Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2020-217066. PMID: 32928740

306. Juge, P.-A., Lee, J.S., Lau, J., Kawano-Dourado, L. … Holers, V.M., …and Dieude, P. 2020. Methotrexate and rheumatoid arthritis associated interstitial lung disease. Eur. Respir. J. doi: 10.1183/13993003.00337-2020. PMID: 32646919

307. Mandava, N., Tirado-Gonzalez, V., Geiger, M.D., Patnaik, J.L, Frazer-Abel, A., Lynch, A.M. Mandava, N., Palestine, A.G., Holers, V.M., Wagner, J.D., Sanchez-Santos, I., Meizner, D., Quiroz-Mercado, H., and Smith, J.M. 2020. Complement activation in the vitreous of patients with proliferative diabetic retinopathy. Invest. Ophthal. Vis. Sci. 61:39. PMCID: PMC7520707

308. Lynch, A.M., Palestine, A.G., Wagner, B.D., Patnaik, J.L., Frazer-Abel, A., Mathia, M.T., Siringo, F.S., Holers, V.M., and Mandava, N. 2020. Complement factors and reticular pseudodrusen in intermediate age-related macular degeneration staged by multimodal imaging. BMJ. Open Ophthal. doi.org/10.1136/bmjophth-2019-000361. PMID: 32509962

309. Ayyappan P., Harms, R.Z., Seifert, J.A., Bemis, E.A., Feser, M.L., Deane, K.D., Demoruelle, M.K., Mikuls, T.R., Holers, V.M., and Sarvetnick, N.E. 2020. Heightened levels of antimicrobial response factors in patients with rheumatoid arthritis. Front. Immunol. 11:427. PMCID: PMC7100537

310. Holers, V.M., Borodovsky, A., Scheinman, R.I., Ho, N., Ramirez, J.R., Dobo, J., Gal, P., Lindenberger, J., Hansen, A.G., Desai, E., Pihl, R., Thiel, S., and Banda, N.K. 2020. Key components of the complement lectin pathway are not only required for the development of inflammatory arthritis but also regulate the transcription of factor D. Front. Immunol. 11:201. PMCID: PMC7046807

311. Song, Y.J, Choi, I.A, Meylan, F., Demoruelle, M.K., Farley, T., Richard, A.C., Hawley, E., Botson, J., Hong, Y.J., Lee, E.Y., Mian, S.R., Hamilton, B.C., Thiele, G.M., Mikuls, T.R., Gara, N., Ward, C.D., Lamberth, S., Deane, K.D., Heller, T., Ward, M.M., Lee, D.M., Migone, T.S., Stohl, W., O’Dell, J.R., Norris, J.M., Holers, V.M., Gregersen, P., Song, Y.W., and Siegel, R.M. 2020. Circulating TNF-like protein 1A (TLA1A) is elevated in rheumatoid arthritis and depends on TNF. Arth. Res. Ther. 22:106. PMCID: PMC7204024

82. Huizinga, T.W., Holers, V.M., Anolik, J., Brenner, M.B., Buckley, C.D., Bykerk, V., Connolly, S.E., Deane, K.D., Guo, J., Hodge, M., Hoffmann, S., Nestle, F., Pitzalis, C. Raychaudhuri, S., Yamamoto, K., Li, Z., Klareskog, L. 2020. Disruptive innovation in rheumatology: new networks of global public-private partnerships are needed to take advantage of scientific progress. Ann. Rheum. Dis. 79:553-555. PMID: 32139419

83. Deane, K.D., and Holers, V.M. 2020. Rheumatoid arthritis: Pathogenesis, prediction and prevention – an emerging paradigm shift. Arth. Rheum. DOI: 10.1002/art.41417. PMID: 32602263

84. Holers, V.M. 2020. Challenges and opportunities: Using omics to generate testable insights into pathogenic mechanisms in preclinical seropositive rheumatoid arthritis. Arth. Rheum. DOI: 10.1002/art.41479. PMID: 32776474

Banda, N.K., Levitt, B., Wood, A.K., Takahashi, K., Stahl, G.L., Holers, V.M., and Arend, W.P. 2009. Complement activation pathways in murine immune complex arthritis and in C3a and C5a generation in vitro. Clin. Exp. Immunol. 159: 100-108

Banda, N.K., Tomlinson, S., Scheinman, R.I., Ho, N., Ramirez, J.R., Mehta, G., Wang, G., Vu, V.P., Simberg, D., Kulik, L., and Holers, V.M. 2020. C2 IgM natural antibody enhances inflammation and its use in the recombinant single chain antibody-fused complement inhibitor C2-Crry to target therapeutics to joints attenuates arthritis in mice. Front. Immunol. 11:575154. PMCID: PMC7596757

Bemis, E.A., Demoruelle, M.K., Seifert, J.A., Polinski, K.J., Weisman, M.H., Buckner, J.H., Gregersen, P.K., Mikuls, T.R., O’Dell, J.R., Keating, R.M., Deane, K.D., Holers, V.M., and Norris, J.M. 2021. Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clinical setting. Ann. Rheum. Dis. 80:154-161 PMCID: PMC7855648

Juge, P.-A., Lee, J.S., Lau, J., Kawano-Dourado, L. … Holers, V.M., …and Dieude, P. 2021. Methotrexate and rheumatoid arthritis associated interstitial lung disease. Eur. Respir. J. Feb 11;57(2):2000337. PMCID: PMC8212188

Takahashi, Kl, Banda, N.K., Holers, V.M., and Van Cott, E.M. 2021. Complement component factor B has thrombin-like activity. Biochem. Biophys. Res. Comm. 552:17-22. PMCID: PMC8035301

Demoruelle, M.K., Wang, H., Davis, R.L., Visser, A., Hoang, J., Norris, J.M., Holers, V.M., Deane, K.D., and Darrah, E. 2021. Anti-peptidyl deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis. Arth. Res.Ther. 23(1):163. PMCID: PMC8182933

Thurman, J.M., Renner, B., Kunchithapautham, K., Ferreira, V.P., Pangburn, M.K., Ablonczy, Z., Tomlinson, S., Holers, V.M., and Rohrer, B. 2009. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J. Biol. Chem. 284:16939-16947.

Gizinski, A.M., Mascolo, M., Kervitsky, D., Meehan, R., Brown, K., Holers, V.M., and Deane, K.D. 2009. Rheumatoid arthritis-specific autoantibodies in interstitial lung disease in the absence of articular symptoms. Clin. Rheum. 28:611-613.

Banda, N.K., Levitt, B., Glogowska, M.J., Thurman, J.M., Takahashi, K., Stahl, G.L., Tomlinson, S., Arend, W.P., and Holers, V.M. 2009. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J. Immunol. 183:5928-5937.

Li, C., Patel, K., Tu, Z., Yang, X., Kulik, L., Alawieh, A., Allen, P., Cheng, Q., Wallace, C., Kilkenny, J., Kwon, J., Gibney, B., Cantu, E,. Sharma, A., Pipkin, M., Machuca, T., Emtiazjoo, A., Goddard, M., Holers, V.M., Nadig, S., Christie, J., Tomlinson, S., and Atkinson, C. 2021. A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury. Am. J.Transplant. 21:2067-2078. PMCID: PMC8246004

Holers, V. M. 2009. Complement in Rheumatoid Arthritis. in Rheumatoid Arthritis (Ed, M.C. Hochberg, A.J. Silman, J.S. Smolen, M.H. Weisman and M.E. Weinblatt), Mosby, Inc. St. Louis, MO.

Serkova, N., Renner, B., Larsen, B., Stoldt, C., Hasebroock, K., Bradshaw, E.L., Holers, V.M., and Thurman, J.M. 2010. Renal inflammation: Targeted iron oxide nanoparticles for molecular MR Imaging in mice. Radiology 255:517-526. PMCID2858816

Polinski, K.J., Armstrong, M., Manke, J., Seifert, J., Crume, T., Yang, F., Clare-Salzler, M., Holers, V.M., Reisdorph, N., and Norris, J.M. 2021. Collection and storage of human plasma for measurement of oxylipins. Metabolites 11(3):137. PMCID: PMC7996814

Lynch, A.M, Murphy, J.R., Gibbs, R.S., Levine, R.J., Giclas, P.C., Salmon, J.E., and Holers, V.M. 2010. Interrelationship of complement activation fragments and angiogenesis-related factors in early pregnancy and their association with preeclampsia. Brit. J. Obstet. Gynecol. 117:456-462. PMID20074261

Polinski, K.J., Bemis, E.A., Yang, F., Crume, T., Demoruelle, M.K., Feser, M., Seifert, J., O'Dell, J.R., Mikuls, T.R., Weisman, M.H., Gregersen, P.K., Keating, R.M., Buckner, J., Reisdorph, N., Deane, K.D., Clare-Salzler, M., Holers. V.M., and Norris, J.M. 2021. Association of lipid mediators with development of future incident inflammatory arthritis in an anti-citrullinated protein antibody-positive population. Arth. Rheum. 73:955-962. PMCID: PMC8169523

Briggs, F.B.S., Ramsay, P.P., Madden, E., Norris, J.M., Holers, V.M., Mikuls, T.R., Sokka, T., Seldin, M.F., Gregersen, P.K., Criswell, L.A., and Barcellos, L.F. 2010. Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. Genes Immun. 11:199-208. PMID20090771

Mangalea, M.R., Paez-Espino, D., Kieft, K., Chatterjee, A., Chriswell, M.E., Seifert, J.A., Feser, M.L., Demoruelle, M.K., Sakatos, A,. Anantharaman, K., Deane, K.D., Kuhn, K.A., Holers, V.M., and Duerkop, B.A. 2021. Individuals at-risk for rheumatoid arthritis harbor differential intestinal bacteriophages communities with distinct metabolic potential. Cell Host Microbe 29:726-739.e5. PMCID: PMC8186507

Okamato, Y., Ghosh, T., Okamoto, T., Schuyler, R.P., Seifert, J., Charry, L.L., Visser, A., Feser, M., Fleischer, C., Pedrick, C., August, J., Moss, L., Bemis, E.A., Norris, J.M., Kuhn, K.A., Demoruelle, M.K., Deane, K.D., Ghosh, D., Holers, V.M.*, and Hsieh, E.W.Y.* 2021. Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4- and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14hi monocytes. J. Autoimmunity. 117:102581. *co-senior authors PMCID: PMC7855988

Wagner, B.D., Patnaik, J.L., Palestine, A.G., Frazer-Abel, A.A., Baldermann, R., Holers, V.M., Mathias, M.T., Mandava, N., and Lynch, A.M. 2021. Association of systemic inflammatory factors with progression to advanced age-related macular degeneration. Ophthal. Epid. 1-10, Apr 08. PMCID: PMC8497647

Bettner, L.F., Peterson, R.A., Bergstedt, D.T., Kelmenson, L.B., Demoruelle, M.K., Mikuls, T.R., Edison, J.D., Parish, M.C., Feser, M.L., Frazer-Abel, A.A., Moss, L.K., Mahler, M., Holers, V.M., and Deane, K.D. 2021. Combinations of anti-cyclic citrullinated protein antibody, rheumatoid factor, and serum calprotectin positivity are associated with the diagnosis of rheumatoid arthritis within 3 years. ACR Open Rheum. doi: 10.1002/acr2.11309. PMID: 34288565

Hughes-Austin, J.M., Ix, J.H., Ward, S.R., Weisman, M.H., O’Dell, J.R., Mikuls, T.R., Buckner, J.H., Gregersen, P.K., Keating, R.M., Demoruelle, M.K., Deane, K.D., Holers, V.M., and Norris, J.M. 2021. Evaluating associations of joint swelling, joint stiffness and joint pain with physical activity in first-degree relatives of patients with rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA), a prospective cohort study. BMJ Open 11(9):e050883. PMCID: PMC8442039

Trachtman, H., Laskowski, J., Lee, C., Renner, B., Feemster, A., Parikh, S., Panzer, S.E., Zhong, W., Cravedi, P., Cantarelli, C., Kulik, L., You, Z., Satchell, S., Rovin, B., Liu, F., Kalled, S.L., Holers, V.M., Jalal, D., and Thurman, J.M. 2021. Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome. Am. Journal of Physiology - Renal Physiology 321:F505-F516. PMCID: PMC8560405

Mankia, K., Siddle, H.J., Kerschbaumer, A., Alpizar Rodriguez, D., Catrina, A.I., Canete, J.D., Cope, A.P., Daien, C.I., Deane, K.D., El Gabalawy, H., Finckh, A., Holers, V.M., Koloumas, M., Ometto, F., Raza, K., Zabalan, C., van der Helm-van Mil, A., van Schaardenburg, D., Aletaha, D., and Emery, P. 2021. EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis. Ann. Rheum. Dis. 80:1286-1298. PMCID: PMC8458095

Wahid, A.A., Dunphy, R.W., Macpherson, A., Gibson, B.G., Kulik, L., Whale, K., Back, C., Hallam, T.M., Alkhawaja, B., Martin, R.L., Meschede, I., Laabei, M., Lawson, A.D.G., Holers, V.M., Watts, A.G., Crennell, S.J., Harris, C.L., Marchbank, K.J., and van den Elsen, J.M.H. Insights into the structure-function relationships of dimeric C3d fragments. 2021. Front. Immunol. 12:714055. PMCID: PMC8381054

Fechtner, S., Berens, H., Bemis, E., Johnson, R.L., Guthridge, C.J., Carlson, N.E., Demoruelle, M.K., Harley, J.B., Edison, J.D., Norris, J.A., Robinson, W.H., Deane, K.D., James, J.A., and Holers, V.M. 2021. Antibody responses to Epstein-Barr virus in the preclinical period of rheumatoid arthritis suggest the presence of increased viral reactivation cycles. Arth. Rheum. doi: 10.1002/art.41994 PMID: 34605217

Okamoto, Y., Devoe, S., Seto, N., Minarchick, V., Wilson, T., Rothfuss, H.M., Mohning, M.P., Arbet, J., Kroehl, M., Visser, A., August, J., Thomas, S.M., Charry, L.L., Fleischer, C., Feser, M.L., Frazer-Abel, A.A., Norris, J.M., Cherrington, B.D., Janssen, W.J., Kaplan, M.J., Deane, K.D., Holers, V.M., and Demoruelle, M.K. 2021. Association of sputum neutrophil extracellular trap subsets with IgA anti-citrullinated protein antibodies in subjects at risk for rheumatoid arthritis. Arth. Rheum. doi: 10.1002/art.419. PMID: 34369110

Deane, K.D., and Holers, V.M. 2021. Rheumatoid arthritis: Pathogenesis, prediction and prevention – an emerging paradigm shift. Arth. Rheum. 73: 181-193. PMCID: PMC7772259

Holers, V.M. 2021. Challenges and opportunities: Using omics to generate testable insights into pathogenic mechanisms in preclinical seropositive rheumatoid arthritis. Arth. Rheum. 73:1-4. PMID: 32776474

Nigrovic, P.A., Colbert, R.A., Holers, V.M., Ozen, S., Ruperto, N., Thompson, S.D., Wedderburn, L.R., Yeung, R.S.M., and Martini, A. 2021. Biological classification of childhood arthritis: roadmap to a molecular nomenclature. Nature Reviews Rheumatology 17:257-269. PMID: 33731872

Ercan, A., Cui, J., Chatterton, D.E.W., Deane, K.D., Hazen, M.M., Brintnell, W., O’Donnell, C., Derber, L., Weinblatt, M.E., Shadick, N.A., Bell, D.A, Cairns, E., Solomon, D.H., Holers, V.M., Rudd, P.M., and Lee, D.M. 2010. IgG galactosylation aberrancy precedes disease onset, correlates with disease activity and is prevalent in autoantibodies in rheumatoid arthritis. Arth. Rheum. 62:2238-2248. PMID20506563

Kolfenbach, J.R., Deane, K.D., Derber, L.A., O’Donnell, C.I., Rosen, A., Darrah, E., Norris, J.M., and Holers, V.M. 2010 Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arth. Rheum. 62:2633-2639. PMCID2946499

Thurman, J.M., Renner, B., Kunchitthapauthan, K., Holers, V.M., and Rohrer, B. 2010. Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. Adv. Exp. Med. Biol. 664:151-158. PMID20238013

Fechtner, S., Berens, H., Bemis, E., Johnson, R.L., Guthridge, C.J., Carlson, N.E., Demoruelle, M.K., Harley, J.B., Edison, J.D., Norris, J.A., Robinson, W.H., Deane, K.D., James, J.A., and Holers, V.M. 2022. Antibody responses to Epstein-Barr virus in the preclinical period of rheumatoid arthritis suggest the presence of increased viral reactivation cycles. Arth. Rheum. 74:597-603. PMCID: PMC8957485

Okamoto, Y., Devoe, S., Seto, N., Minarchick, V., Wilson, T., Rothfuss, H.M., Mohning, M.P., Arbet, J., Kroehl, M., Visser, A., August, J., Thomas, S.M., Charry, L.L., Fleischer, C., Feser, M.L., Frazer-Abel, A.A., Norris, J.M., Cherrington, B.D., Janssen, W.J., Kaplan, M.J., Deane, K.D., Holers, V.M., and Demoruelle, M.K. 2022. Association of sputum neutrophil extracellular trap subsets with IgA anti-citrullinated protein antibodies in subjects at risk for rheumatoid arthritis. Arth. Rheum. 74:38-48. PMCID: PMC8712364

Schriek, P., Ching, A.C., Moily, N.S., Moffat, J., Beattie, L., Steiner, T.M., Hosking, L.M., Thurman, J.M., Holers, V.M., Ishido, S., Lahoud, M.H., Caminschi, I., Heath, W.R., Mintern, J.D., and Villadangos, J.A. 2022. Marginal zone B cells acquire dendritic cell functions by trogocytosis. Science 375(6581):eabf7470. doi: 10.1126/science.abf7470. PMID: 35143312

Wong, C.J., Wang, L., Holers, V.M., Frazer-Abel, A., van der Maarel, S.M., Tawil, R., Statland, J.M., and Tapscott, S.J. 2022. Elevated plasma complement components in facioscapulohumeral dystrophy. Hum. Mol. Genet. 31:1821-1829. PMCID: PMC 9169453

Sasaki, T., Bracero, S., Keegan, J., Chen, L., Cao, Y., Stevens, E., Qu, Y., Wang, G., Nguyen, J., Sparks, J.A., Holers, V.M., Alves, S.E., Lederer, J.A., Costenbader, K.H., and Rao, D.A. 2022. Longitudinal immune cell profiling in early systemic lupus erythematosus. Arth. Rheum. 74:1808-1821. PMID: 35644031

Wagner, B.D., Patnaik, J.L., Palestine, A.G., Frazer-Abel, A.A., Baldermann, R., Holers, V.M., Mathias, M.T., Mandava, N., and Lynch, A.M. 2022. Association of systemic inflammatory factors with progression to advanced age-related macular degeneration. Ophthal. Epidemiol. 29:139-148. PMCID: PMC8497647

Smith, J.M., Mandava, N., Tirado-Gonzalez, V., Garcia-Santisteban, R., Geiger, M.D., Patnaik, J.L., Frazer-Abel, A., Lynch, A.M., Mandava, N., Holers, V.M., Wagner, B.D., Sanchez-Santos, I., Meizner, D., Quiroz-Mercado, H., and Palestine, A.G. 2022. Correlation of complement activation in aqueous and vitreous in patients with proliferative diabetic retinopathy. Transl. Vis. Sci. Technol. doi: 10.1167/tvst.11.4.13. PMCID: PMC9034714

Marin, A.I., Poppelaars, F., Wagner, B.D., Palestine, A.G., Patnaik, J.L., Holers, V.M., Frazer-Abel, A.A., Mathias, M.T., Manoharan, N., Fonteh, C.N., Mandava, N., Lynch, A.M., and University of Colorado Retina Research Group. 2022. Sex and age-related differences in complement factors among patients with intermediate age-related macular degeneration. Transl. Vis. Sci. Technol. doi: 10.1167/tvst.11.5.22. PMCID: PMC9145081

Fahnoe, K.C., Liu, F., Morgan, J.G., Ryan, S.T., Storek, M., Stark, E.G., Taylor, F.R., Holers, V.M., Thurman, J.M., Wawersik, S., Kalled, S.L., and Violette SM. 2022. Development and optimization of bifunctional fusion proteins to locally modulate complement activation in diseased tissue. Front Immunol. doi: 10.3389/fimmu.2022.869725. PMCID: PMC9244803

Quan, T.E., Roman, R.M., Rudenga, B.J., Holers, V.M., and Craft, J. 2010. Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells. Arth. Rheum. 62:1693-1701. PMCID2885535

Deane, K.D., O'Donnell, C.I., Hueber, W., Majka, D.S., Lazar, A.A., Derber, L.A., Gilliland, W.R., Edison, J.D., Norris, J.M., Robinson, W.H., and Holers, V.M. The number of elevated cytokines/chemokines in pre-clinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner. Arth. Rheum. 62:3161-3172. PMCID2980824

Kovacs, J.M., Hannan, J.P., Eisssenmesser, E.Z., and Holers, V.M. 2010. Biophysical investigations of complement receptor 2 (CD21. CR2) ligand interactions reveal amino acid contacts unique to each receptor-ligand pair. J. Biol. Chem. 285:27251-27258. PMCID 2930724

Bergstedt, D.T., Tarter, W.J., Peterson, R.A., Feser, M.L., Parish, M.C., Striebich, C.C., Demoruelle, M.K., Moss, L., Bemis, E.A., Norris, J.M., Holers, V.M., Edison, J.D., Thiele, G.M., Mikuls, T.R., and Deane KD. 2022. Antibodies to citrullinated protein antigens, rheumatoid factor isotypes and the shared epitope and the near-term development of clinically-apparent rheumatoid arthritis. Front Immunol. doi: 10.3389/fimmu.2022.916277. PMCID: PMC9265214

Banda, N.K., Deane, K.D., Bemis, E.A., Strickland, C., Seifert, J., Jordan, K., Goldman, K., Morgan, B.P., Moreland, L.W., Lewis, M.J., Pitzalis, C., and Holers V.M. 2022. Analysis of complement gene expression, clinical associations, and biodistribution of complement proteins in the synovium of early rheumatoid arthritis patients reveals unique pathophysiologic features. J. Immunol. 208:2482-2496. PMCID: PMC9133225

Vanderlinden, L.A., Bemis, E.A., Seifert, J., Guthridge, J.M., Young, K.A., Demoruelle, M.K., Feser, M., DeJager, W., Macwana, S., Mikuls, T.R., O'Dell, J.R., Weisman, M.H., Buckner, J., Keating, R.M., Gaffney, P.M., Kelly, J.A., Langefeld, C.D., Deane, K.D., James, J.A., Holers, V.M., and Norris, J.M. 2022. Relationship between a vitamin D genetic risk score and autoantibodies among first-degree relatives of probands with rheumatoid arthritis and systemic lupus erythematosus. Front. Immunol. doi: 10.3389/fimmu.2022.881332. PMCID:PMC9205604

Tsaltskan, V., Nguyen, K., Eaglin, C., Holers, V.M., Deane, K.D., and Firestein, G.S. 2022. Comparison of web-based advertising and a social media platform as recruitment tools for underserved and hard-to-reach populations in rheumatology clinical research. ACR Open Rheumatol. 4:623-630. PMCID: PMC9274346

Chriswell, M.E., Lefferts, A.R., Clay, R.R., Hsu, A.R., Seifert, J., Feser, M.L., Rims, C., Bloom, M.S., Bemis, E.A., Li, S., Maerz, M.D., Frank, D.N., Demoruelle, M.K., Deane, K.D., James, E.A., Buckner, J.H., Robinson, W.H., Holers, V.M., and Kuhn, K.A. 2022. Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum. Science Translational Medicine. doi: 10.1126/scitranslmed.abn5166. Epub 2022 Oct 26 PMID: 36288282

Seifert, J.A., Bemis, E.A., Ramsden, K., Lowell, C., Polinski, K., Fleischer, C., Demoruelle, M.K., Buckner, J., Gregersen, P.K., Keating, R.M., Mikuls, T.R., O’Dell, J.R., Weisman, M.H., Deane, K.D., Norris, J.M., Steere, A.C., and Holers, V.M. 2022. Association of antibodies to Prevotella copri in anti-CCP-positive individuals at-risk for developing rheumatoid arthritis and in those with early or established rheumatoid arthritis. Arth. Rheum. doi: 10.1002/art.42370. PMID: 36259174

Renner, B., Laskowski, J., Poppelaars, F., Ferreira, V.P., Blaine, J., Antonioli, A.H., Hannan, J.P., Kovacs, J.M., van Kooten, C., You, Z., Pickering, M.C., Holers, V.M., and Thurman, J.M. 2022. Factor H related proteins modulate complement activation on kidney cells. Kidney Intl. 102:1331-1344. PMCID: PMC9691546

Holers, V.M., Kuhn, K.A., Demoruelle, M.K., Norris, J.M., Firestein, G.S., James, E.A., Robinson, W.H., Buckner, J.H., and Deane, K.D. 2022. Mechanism-driven strategies for prevention of rheumatoid arthritis. Rheumatol. Autoimmun. 2: 109-119. PMCID: PMC9610829

Holers, V.M. 2022. Contributions of animal models to mechanistic understandings of antibody-dependent disease and roles of the amplification loop. Immunol. Rev. doi: 10.1111/imr.13136. PMID: 36111456

Olsen, N.J., Okuda, D.T., Holers, V.M., and Karp, D.R. 2022. Editorial: Understanding the concept of pre-clinical autoimmunity. Front. Immunol. doi: 10.3389/fimmu.2022.983310. PMCID: PMC9355672

West, S.G., and Holers, V.M. 2022. Clinical academic rheumatology: Still getting more than you pay for. Arth. Care Res. 74:1039-1040. PMID: 36194068

Renner, B., Amura, C.R., Ljubanovic, D., Glogowska, M.J., Takahashi, K., Stahl, G.L., Carroll, M.C., Holers, V.M., and Thurman, J.M. 2010. B cell subsets contribute to both renal injury and renal protection after ischemia/reperfusion. J. Immunol. 185:3086-3094. PMID20810984

Banda, N.K., Takahashi, M., Levitt, B., Glogowska, M., Nicholas, J., Takahashi, K., Stahl, G.L., Fujita, T., Arend, W.P., and Holers, V.M. 2010. Essential role of complement MASP-1/3 in the murine collagen antibody-induced arthritis model of inflammatory arthritis. J. Immunol. 185:5598-5606. PMID20870940

Tan, W., Wu, H., Zhao, J., Derber, L.A., Lee, D.M., Shadick, N.A., Conn, D.L, Smith, E.A., Gersub, V., Nepom, G.T., Moreland, L.W., Furst, D.E., Thompson, S.D., Jonas, B.L., Holers, V.M., Glass, D.N., Chen, P.P., Bridges, S.L, Weinblat, M.E., Paulus, H.E., and Tsao, B..P. 2010. A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis. Arth. Rheum. 62:2864-2875. PMCID 2944013

Shaw, C.D., Storek, M.J., Young, K.A., Thurman, J.M., Holers. V.M., and Hannan, J.P. 2010. Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking. J. Mol. Biol. 404:697-710. PMID20951140

Seifert, J.A., Bemis, E.A., Ramsden, K., Lowell, C., Polinski, K., Fleischer, C., Demoruelle, M.K., Buckner, J., Gregersen, P.K., Keating, R.M., Mikuls, T.R., O’Dell, J.R., Weisman, M.H., Deane, K.D., Norris, J.M., Steere, A.C., and Holers, V.M. 2023. Association of antibodies to Prevotella copri in anti-CCP-positive individuals at-risk for developing rheumatoid arthritis and in those with early or established rheumatoid arthritis. Arth. Rheum. 75:507-516. PMCID: PMC10065886

Holers, V.M., Frank, R.M., Clauw, A., Seifert, J., Zuscik, M., Asokan, S., Striebich, C., Clay, M.R., Moreland, L.W., and Banda, N.K. 2023. Potential causal role of synovial complement system activation in the development of post-traumatic osteoarthritis after anterior cruciate ligament injury or meniscus tear. Front. Immunol. 2023 doi: 10.3389/fimmu.2023.1146563. PMCID: PMC10189880

Renner, B., Poppelaars, F., Laskowski, J., Serkova, N.J., Kulik, L., Holers, V.M., and Thurman, J.M. 2023. Noninvasive detection of iC3b/C3d deposits in the kidney using a novel bioluminescent imaging probe. J. Am. Soc. Nephrol. 34:1151-1154. PMCID: PMC10356150

Brewer, R.C., Lanz, T.V., Hale, C.R., Sepich-Poore, G.D., Martino, C., Swafford, A.D., Carroll, T.S., Kongpachith, S., Blum, L.K., Elliott, S.E., Blachere, N.E., Parveen, S., Fak, J., Yao, V., Troyanskaya, O., Frank, M.O., Bloom, M.S., Jahanbani, S., Gomez, A.M., Iyer, R., Ramadoss, N.S., Sharpe, O., Chandrasekaran, S., Kelmenson, L.B., Wang, Q., Wong, H., Torres, H.L., Wiesen, M., Graves. D.T., Deane, K.D., Holers, V.M., Knight, R., Darnell, R.B., Robinson, W.H., and Orange, D.E. 2023. Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Sci. Transl. Med. doi: 10.1126/scitranslmed.abq8476. Epub 2023 Feb 22. PMCID: PMC10496947

Moon, J.S., Younis, S., Ramadoss, N.S., Iyer, R., Sheth, K., Sharpe, O., Rao, N.L., Becart. S., Carman, J.A., James, E.A., Buckner, J.H., Deane, K.D., Holers, V.M., Goodman, S.M., Donlin, L.T., Davis, M.M., and Robinson, W.H. 2023. Cytotoxic CD8 T cells target citrullinated antigens in rheumatoid arthritis. Nat. Commun. doi:10.1038/s41467-022-35264-8. PMCID: PMC9852471

Renner, B., Ferreira, V.P., Cortes, C., Goldberg, R., Ljubanovic, D., Pangburn, M.K., Pickering, M.C., Tomlinson, S., Holers, V.M., and Thurman, J.M. 2010. The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells. J. Immunol. 185:3086-3094. PMID20675597

Sarkar, S., Elliott, E.C., Henry, H.R., Ludovico, I.D., Melchior, J.T., Frazer-Abel, A., Webb-Robertson, B.J., Davidson, W.S., Holers, V.M., Rewers, M.J., Metz, T.O., and Nakayasu, E.S. 2023. Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response. Update in: Clin. Proteomics. 20:38. PMCID: PMC9980237

Webb-Robertson, B.M., Nakayasu, E.S., Dong, F., Waugh, K.C., Flores, J., Bramer, L.M., Schepmoes, A., Gao, Y., Fillmore, T., Onengut-Gumuscu, S., Frazer-Abel, A., Rich, S.S., Holers, V.M., Metz, T.O., and Rewers, M.J. 2023. Decrease in multiple complement protein levels is associated with the development of islet autoimmunity and type 1 diabetes. medRxiv Jul 16:2023.07.13.23292628. doi: 10.1101/2023.07.13.23292628. PMCID: PMC10370226

Onengut-Gumuscu, S., Webb-Robertson, B.M., Sarkar, S., Manichaikul, A., Hu, X., Frazer-Abel, A., Holers, V.M., Rewers, M.J., and Rich, S.S. 2023. Genetic variants in the complement system and their potential link in the aetiology of type 1 diabetes. Diabetes Metab. Res. Rev. Aug 30:e3716. doi: 10.1002/dmrr.3716. PMID:37649398

Whelan, R., Feemster, A., Laskowski, J., Renner, B., Kulik, L., Poppelaars, F., Lee, C., Holers, V.M., and Thurman, J.M. 2023. Female but not male mice deficient in soluble IgM Are susceptible to chemically induced glomerular injury. J. Immunol. 211:1240-1248. PMCID:PMC10592129

Weisenfeld, D., Zhang, F., Donlin, L., Jonsson, A.H., Apruzzese, W., Campbell, D.; Accelerating Medicines Partnership Program: RA/SLE Network; Rao, D.A., Wei, K., Holers, V.M., Gravallese, E., Moreland, L., Goodman, S., Brenner, M., Raychaudhuri, S., Filer, A., Anolik, J., Bykerk, V., and Liao, K.P. 2023. Associations between rheumatoid arthritis clinical factors with synovial cell types and states. Arth. Rheum. doi: 10.1002/art.42726. PMID: 37791989

Deane, K.D., Norris, J.M., and Holers, V.M. 2010. Pre-clinical rheumatoid arthritis: identification, evaluation and future directions for investigation. Rheum. Dis. Clin. NA 13:236-241. PMCID2879710

Li, ,Y., Jacques, S., Gaikwad, H., Wang, G., Banda, N.K., Holers, V.M., Scheinman, R.I., Tomlinson, S., Moghimi, S.M., and Simberg, D. 2023. Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins. Nat Nanotechnol. doi:10.1038/s41565-023-01514-z. PMID: 37798566

Holers, V.M. 2010. Systemic lupus erythematosus: the complement system. in Rheumatology 5th Edition (Ed, M.C. Hochberg, A.J. Silman, J.S. Smolen, M.H. Weisman and M.E. Weinblatt), Mosby, Inc. St. Louis, MO.

Rohrer, B., Long, Q., Coughlin, B., Renner, B., Huang, Y., Kunchithapautham, K., Ferreira, V., Pangburn, M., Gilkeson, G., Thurman, J., Tomlinson, S., and Holers, V.M. 2010. A targeted inhibitor of the complement alternative pathway in models of age-related macular degeneration. in Inflammation and retinal disease: complement biology and pathology. Adv. Exp. Med. Biol. 703: 137-149. PMID20711712

Mueller, A.A., Sasaki, T., Keegan, J.W., Nguyen, J.P., Griffith, A., Horisberger, A.M., Licata, T., Fieg, E., Cao, Y., Elahee, M., Marks, K.E., Simmons, D.P., Briere, L.C., Cobban, L.A., Pallais, J.C., High, F.A., Walker, M.A., Linnoila, J.J., Sparks, J.A., Holers, V.M., Costenbader, K.H., Network Udn UD, Sweetser, D.A., Krier, J.B., Loscalzo, J., Lederer, J.A., and Rao, D.A. 2023. High-dimensional immunophenotyping reveals immune cell aberrations in patients with undiagnosed inflammatory and autoimmune diseases. J. Clin. Invest. doi:10.1172/JCI169619. PMID: 37874643

Zhang, F., Jonsson, A.H., Nathan, A., Millard, N., Curtis, M., Xiao, Q., Gutierrez-Arcelus, M., Apruzzese, W., Watts, G.F.M., Weisenfeld, D., Nayar, S., Rangel-Moreno, J., Meednu, N., Marks, K.E., Mantel, I., Kang, J.B., Rumker, L., Mears, J., Slowikowski, K., Weinand, K., Orange, D.E., Geraldino-Pardilla, L., Deane, K.D., Tabechian, D., Ceponis, A., Firestein, G.S., Maybury, M., Sahbudin, I., Ben-Artzi, A., Mandelin, A.M., Nerviani, A., Lewis, M.J., Rivellese, F., Pitzalis, C., Hughes, L.B., Horowitz, D., DiCarlo, E., Gravallese, E.M., Boyce, B.F.; Accelerating Medicines Partnership: RA/SLE Network; Moreland, L.W., Goodman, S.M., Perlman, H., Holers, V.M., Liao, K.P., Filer, A., Bykerk, V.P., Wei, K., Rao, D.A., Donlin, L.T., Anolik, J.H., Brenner, M.B., and Raychaudhuri, S. 2023. Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes. Nature. 623:616-624. PMCID: PMC10651487

James, E.A.*, Holers, V.M.*, Iyer, R., Prideaux, E.B., Rao, N.L., Rims, C., Muir, V.S., Posso, S.E., Bloom, M.S., Zia, A., Elliott, S.E., Adamska, J.Z., Ai, R., Brewer, R.C., Seifert, J.A., Moss, L., Barzideh, S., Demoruelle, M.K., Striebich, C.C., Okamoto, Y., Sainbayar, E., Crook, A.A., Peterson, R.A., Vanderlinden, L.A., Wang, W., Boyle, D.L., Robinson, W.H., Buckner, J.H., Firestein, G.S., and Deane, K.D. 2023. Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis. Nat. Commun. doi:10.1038/s41467-023-43091-8. *Co-first author. PMCID: PMC10665556

Edelhauser, H.F., Rowe-Rendleman, C.L., Robinson, M.R., Dawson, D.G., Chader, G.J., Grossniklaus, H.E., Rittenhouse, K.D., Wilson, C.G., Weber, D.A., Kuppermann, B.D., Csaky, K.G., Olsen, T.W., Kompella, U.B., Holers, V.M., Hageman, G.S., Gilger, B.C., Campochiaro, P.A., Whitcup, S.M., and Wong, W.T. 2010. Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications. Inv. Ophthalmol. Vis. Sci. 51:5403-5420. PMID 20980702

Holers, V.M. 2023. Contributions of animal models to mechanistic understandings of antibody-dependent disease and roles of the amplification loop. Immunol. Rev. 313:181-193. PMID: 36111456

Kemper, C., Ferreira, V.P., Paz, J.T., Holers, V.M., Lionakis, M.S., and Alexander, J.J. 2023. Complement: The Road Less Traveled. J. Immunol. 210:119-125. PMCID: PMC10038130

Willis, V.C., Gizinski, A.M., Banda, N.K., Knuckley, B., Cordova, K., Luo, Y., Causey, C.P., Levitt,B., Glogowska, M., BenBarak, M., Chandra, P., Kulik, L., Robinson, W.H., Arend, W.P., Thompson, P.R., and Holers, V.M. 2011. Cl-amidine, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. J. Immunol. 186:4396-4404.

Lynch, A.M., Gibbs, R.S., Murphy, J.R., Giclas, P.C., Salmon, J.E., and Holers V.M.. 2011. Early elevations of the complement activation fragment C3a and adverse pregnancy outcomes. Obstet. Gynecol. 117:75-83.

Navarra, S.V., Ishimori, M.L., Uy, E.A., Hamijoyo, L., Sama, J., James, J.A., Holers, V.M., and Weisman, M.H. 2011. Studies of Filipino patients with systemic lupus erythematosus (SLE): autoantibody profile of first degree relatives. Lupus 20:537-543.

Holers, V. M. 2023. Complement therapeutics are coming of age in rheumatology. Nat. Rev. Rheumatol. 19:470-485. PMID: 37337038.

Holers, V. M. 2023. Are there causal mucosal drivers in the preclinical development of rheumatoid arthritis? Semin. Art. Rheum. doi: 10.1016/j.semarthrit.2023.152324.

Rohrer, B., Coughlin, B., Kunchithapautham, K., Long, Q., Tomlinson, S., Takahashi, K., and Holers, V.M. 2011. The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. Mol. Immunol. 48(6-7):e1-8.

Kulik, L., Chen, K., Huber, B.T., and Holers, V.M. 2011. Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists. Mol. Immunol. 48:883-894.

Banda, N.K., Takahashi, M., Takahashi, K., Stahel, G.L., Hyatt, S., Glogowska, M., Wiles, T.A., Endo, Y., Fujita, T., Holers, V.M., and Arend, W.P. 2011. Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement. Mol. Immunol. 49:281-289.

Renner, B., Ferreira, V.P., Cortes, C., Goldberg, R., Ljubanovic, D., Pangburn, M.K., Pickering, M.C., Tomlinson, S., Holland-Neidermyer, A., Strassheim, D., Holers, V.M, Holers, V.M., and Thurman, J.M. 2011. Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney Intl. 80:165-173.

Fridkis-Hareli, M., Storek, M., Mazsaroff, I., Risitano, A., Lundberg, A.S., Horvath, C.J., and Holers, V.M. 2011. Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases. Blood 118:4705-4713.

Khan, M.A., Jiang, X., Dhillon, G., Beilke, J., Holers, V.M., Atkinson, C., Tomlinson, S., Nicolls, M.R. 2011. CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants. Circulation Res. 109:1290-1301.

Karp, D. R., and Holers, V. M. 2011. Complement in health and disease in Cecil Textbook of Medicine, W. B. Saunders, Inc., Orlando, FL.

Banda, N.K., Hyatt, S., Antonioli, A.H., Glogowska, M., Takahashi, K., Merkel, T.J., Stahl, G.L., Mueller-Ortiz, S., Wetsel, R., Arend, W.P., and Holers, V.M. 2012. Roles of C3a receptors, C5a receptors and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. J Immunol. 188:1469-1478. PMCID: PMC3262949

Rohrer, B., Coughlin, B., and Holers, V.M. 2012. Systemic CR2-targeted complement alternative pathway inhibitor treatment ameliorates mouse laser-induced choroidal neovascularization. J. Ocul. Pharmacol. Ther. 28:402-409. PMCID: PMC3406320

Takeda, K., Thurman, J.M., Tomlinson, S., Okamoto, M., Shiraishi, Y., Ferreira, V.P., Cortes, C., Pangburn, M.K., Holers, V.M., and Gelfand, E.W. 2012. The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness (AHR) and inflammation. J. Immunol. 188:661-667. PMCID: PMC3253223

Demoruelle, M.K., Weisman, M.H., Simonian, P.L., Lynch, D.A., Sachs, P.B., Pedraza, I.F., Harrington, A.R., Kolfenbach, J.R., Striebich, C.C., Pham, Q.N., Strickland, C.D., Petersen, B.D, Parish, M.C., Derber, L.A., Norris, J.M., Holers, V.M., and Deane, K.D. 2012. Airway abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arth. Rheum. 64:1756-1761. PMCID: PMC3319006

Sokolove, J. Bromberg, R., Tibshirani, R.J., Deane, K.D., Lahey, L.J., Derber, L.A., Chandra, P.E., Edison, J.D., Gilliland, W.R., Tibshirani, R.J., Norris, J.D., Holers, V.M., and Robinson, W.R. 2012. Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. PLoS One 7(5):e35296. PMCID: PMC3360701

Pappworth, I.Y., Hayes, C., Morgan, B.P., Holers, V.M., and Marchbank, K.J. 2012. Mice expressing human CR1/CD35 have an enhanced immune response to T-dependent antigens but fail to correct the effect of premature CR2 expression. Immunobiology 217: 147-157. PMID: 21783272

Elvington, A., Atkinson, C., Kulik, L., Zhu, H., Yu, J., Kindy, M.S., Holers, V.M., and Tomlinson, S. 2012 Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice. J. Immunol. 188:1460-1468. PMCID: PMC3262954

Keith, R.C., Powers, J.L., Redente, E.F., Sergew, A., Martin, R.J., Gizinski, A., Holers, V.M., Sakaguchi, S., and Riches, D.W. 2012. A novel model of rheumatoid arthritis-associated interstitial lung diseae in SKG mice. Exper. Lung Res. 38:55-66. PMID: 22185348

Li, K., Gor, J., Holers, V.M., Storek, M.J., and Perkins, S.J. 2012. Solution structure of TT30, a novel complement therapeutic agent, provides insight into its joint binding to complement C3b and C3d. J. Mol. Biol. 418:248-263. PMID: 22387467

Weckbach, S., Neher, M., Losacco, J.T., Bolden, A.L., Kulik, L., Flierl, M.A., Bell, S.E., Holers, V.M., and Stahel, P.F. 2012. Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injury. J. Neurotrauma 29: 1233-1242. PMCID: PMC3325549

Lynch, A.M., Eckel, R.H., Murphy, J.R., Gibbs, R.S., West, N.A., Giclas, P.C., Salmon, J.E., and Holers, V.M. 2012. Prepregnancy obesity and complement system activation in early pregnancy and the subsequent development of preeclampsia. Am. J. Obstet. Gynecol. 206: 428.e1-8. PMID: 22542119

Liubchenko, G.A., Appleberry, H.C., Holers, V.M., Banda, N.K., Willis, V.C., and Lyubchenko, T. 2012. Potentially autoreactive naturally occurring transitional T3 B lymphocytes exhibit a unique signaling profile. J. Autoimmun. 38:293-303. PMCID: PMC3358596

Thurman, J.M., Tchepeleva, S.N., Haas, M., Panzer, S., Boackle, S.A., Glogowska, M.J., Quigg, R.J., and Holers, V.M. 2012. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J. Physiol. – Renal Physiol. 302:F1529-1536. PMCID: PMC3378099

Risitano, A.M., Notaro, R., Pascariello, C., Sica M. del Vecchio, L, Horvath, C.J., Fridkis-Hareli, M., Selleri, C., Lindorfer, M.A., Taylor, R.P., Luzzatto, L, and Holers, V.M. 2012. The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment deposition. Blood 119:6307-6316. PMID: 22577173

Asokan, R., Banda, N.K., Szakonyi, G., Chen, X.S., and Holers, V.M. 2012. Human complement receptor 2 (CR2/CD21) as a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE). Mol. Immunol. 53:99-110. PMCID: PMC3439536

Mikuls, T.R., Thiele, G.M., Deane, K.D., Payne, J.B., O’Dell, J.R., Yu, F., Salyes, H., Weisman, M.H., Gregersen, P.K., Buckner, J.H., Keating, R.M., Derber, L.A., Robinson, W.H., Holers, V.M., and Norris, J.M. 2012. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arth. Rheum. 64:3522-3530. PMCID: PMC3467347

Hughes-Austin, J.M., Deane, K.D., Derber, L.A., Kolfenbach, J.R., Zerbe, G.O., Sokolove, J., Lahey, L.J., Weisman, M.H., Buckner, J.H., Mikuls, T.R., O'Dell, J.R., Keating, R.M., Gregersen, P.K., Robinson, W.H., Holers, V.M., and Norris J.M. 2012. Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA). Ann. Rheum. Dis. 2012 Aug 21. [Epub ahead of print]. PMID: 22915618

Liubchenko, G.A., Appleberry, H.C., Striebich, C.C., Franklin, K.E., Derber, L.A., Holers, V.M., and Lyubchenko, T. 2012. Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes. J. Autoimmun. Oct 8. pii: S0896-8411(12)00125-4[Epub ahead of print]. PMCID: PMC3546227

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