Edwin Liu, MD

Professional Titles

• Director, Colorado Center for Celiac Disease
• Taplin Endowed Chair for Celiac Disease

Recognitions

• Taplin Endowed Chair for Celiac Disease, Children's Hospital Colorado (2014)
  
• Clinical Young Investigator Award, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) (2010)
  
• Conference Travel Award, Federation of Clinical Immunology Societies (FOCIS) (2006)
  Supported by UCB Pharma
• Young Investigator Award, Millenium Pharmaceuticals (2004)
  
• Conference Travel Award, Federation of Clinical Immunology Societies (FOCIS) (2004)
  
• Conference Travel Award, Federation of Clinical Immunology Societies (FOCIS) (2003)
  
• Conference Travel Award, Federation of Clinical Immunology Societies (FOCIS) (2002)
  
• Conference Travel Award, Federation of Clinical Immunology Societies (FOCIS) (2001)
  
• Outstanding Fellow Teaching Award - Gastroenterology, Hepatology, and Nutrition, University of Colorado School of Medicine (2000)
  

Publications

• Aronsson CA, Lee HS, Liu E, Uusitalo U, Hummel S, Yang J, Hummel M, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Krischer J, Virtanen SM, Norris JM, Agardh D, TEDDY STUDY GROUP. Age at gluten introduction and risk of celiac disease. Pediatrics. 2015 Feb;135(2):239-45. PubMed PMID: 25601977
• Liu E, McDaniel K, Case S, Yu L, Gerhartz B, Ostermann N, Fankhauser G, Hungerford V, Zou C, Luyten M, Seidl KJ, Michels AW. Exploring T cell reactivity to gliadin in young children with newly diagnosed celiac disease. Autoimmune Dis. 2014;2014:927190. PubMed PMID: 24724018
• Liu E, Lee HS, Aronsson CA, Hagopian WA, Koletzko S, Rewers MJ, Eisenbarth GS, Bingley PJ, Bonifacio E, Simell V, Agardh D, TEDDY Study Group. Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med. 2014 Jul 3;371(1):42-9. PubMed PMID: 24988556
• Liu E, Lee HS, Agardh D. Risk of celiac disease according to HLA haplotype and country. N Engl J Med. 2014 Sep 11;371(11):1074. PubMed PMID: 25207776
• Simmons KM, McFann K, Taki I, Liu E, Klingensmith GJ, Rewers MJ, Frohnert BI. Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes. J Pediatr. 2015 Nov 7. [Epub ahead of print] PubMed PMID: 26561381
• Andrén Aronsson C, Lee HS, Koletzko S, Uusitalo U, Yang J, Virtanen SM, Liu E, Lernmark Å, Norris JM, Agardh D. Effects of Gluten Intake on Risk of Celiac Disease: a case-control study on a Swedish birth cohort. Clin Gastroenterol Hepatol. 2015 Oct 7. [Epub ahead of print] PubMed PMID: 26453955
• Gutierrez-Achury J, Romanos J, Bakker SF, Kumar V, de Haas EC, Trynka G, Ricaño-Ponce I, Steck A, Chen WM, Onengut-Gumuscu S, Simsek S, Rewers M, Mulder CJ, Liu E, Rich SS, Wijmenga C. Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity. Diabetes Care. 2015 Oct;38 Suppl 2:S37-44. PubMed PMID: 26405070
• Hadley D, Hagopian W, Liu E, She JX, Simell O, Akolkar B, Ziegler AG, Rewers M, Krischer JP, Chen WM, Onengut-Gumuscu S, Bugawan TL, Rich SS, Erlich H, Agardh D. HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study. Am J Gastroenterol. 2015 Jun;110(6):915-20. PubMed PMID: 26010309
• Agardh D, Lee HS, Kurppa K, Simell V, Aronsson CA, Jörneus O, Hummel M, Liu E, Koletzko S. Clinical features of celiac disease: a prospective birth cohort. Pediatrics. 2015 Apr;135(4):627-34. PubMed PMID: 25733751
• Aronsson CA, Lee HS, Liu E, Uusitalo U, Hummel S, Yang J, Hummel M, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Krischer J, Virtanen SM, Norris JM, Agardh D. Age at gluten introduction and risk of celiac disease. Pediatrics. 2015 Feb;135(2):239-45. PubMed PMID: 25601977
• Liu E, Lee HS, Aronsson CA, Hagopian WA, Koletzko S, Rewers MJ, Eisenbarth GS, Bingley PJ, Bonifacio E, Simell V, Agardh D. Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med. 2014 Jul 3;371(1):42-9. PubMed PMID: 24988556
• Liu E, Lee HS, Agardh D. Risk of celiac disease according to HLA haplotype and country. N Engl J Med. 2014 Sep 11;371(11):1074. PubMed PMID: 25207776
• Lönnrot M, Lynch K, Larsson HE, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Ziegler AG, Akolkar B, Krischer J, Hyöty H. A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY. BMC Pediatr. 2015 Mar 20;15:24. PubMed PMID: 25884839
• Steck AK, Vehik K, Bonifacio E, Lernmark A, Ziegler AG, Hagopian WA, She J, Simell O, Akolkar B, Krischer J, Schatz D, Rewers MJ. Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care. 2015 May;38(5):808-13. PubMed PMID: 25665818
• Romanos J, Rosén A, Kumar V, Trynka G, Franke L, Szperl A, Gutierrez-Achury J, van Diemen CC, Kanninga R, Jankipersadsing SA, Steck A, Eisenbarth G, van Heel DA, Cukrowska B, Bruno V, Mazzilli MC, Núñez C, Bilbao JR, Mearin ML, Barisani D, Rewers M, Norris JM, Ivarsson A, Boezen HM, Liu E, Wijmenga C. Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants. Gut. 2014 Mar;63(3):415-22. PubMed PMID: 23704318
• Kemppainen KM, Lynch KF, Liu E, Lönnrot M, Simell V, Briese T, Koletzko S, Hagopian W, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Lernmark Å, Hyöty H, Triplett EW, Agardh D. Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life. Clin Gastroenterol Hepatol. 2016 Nov 10. [Epub ahead of print] PubMed PMID: 27840181
• Kelly CP, Bai JC, Liu E, Leffler DA. Advances in Diagnosis and Management of Celiac Disease. Gastroenterology. 2015 Feb 3. [Epub ahead of print] PubMed PMID: 25662623
• Törn C, Liu X, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler AG, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Sharma A, Steck A, Krischer J. Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study. Sci Rep. 2016 Jun 16;6:27887. PubMed PMID: 27306948
• Sharma A, Liu X, Hadley D, Hagopian W, Liu E, Chen WM, Onengut-Gumuscu S, Simell V, Rewers M, Ziegler AG, Lernmark Å, Simell O, Toppari J, Krischer JP, Akolkar B, Rich SS, Agardh D, She JX. Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort. PLoS One. 2016 Mar 25;11(3):e0152476. PubMed PMID: 27015091
• Simmons KM, McFann K, Taki I, Liu E, Klingensmith GJ, Rewers MJ, Frohnert BI. Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes. J Pediatr. 2016 Feb;169:44-8.e1. PubMed PMID: 26561381
• Uusitalo U, Liu X, Yang J, Aronsson CA, Hummel S, Butterworth M, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler AG, Akolkar B, Krischer J, Norris JM, Virtanen SM. Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. JAMA Pediatr. 2016 Jan;170(1):20-8. PubMed PMID: 26552054
• Andrén Aronsson C, Lee HS, Koletzko S, Uusitalo U, Yang J, Virtanen SM, Liu E, Lernmark Å, Norris JM, Agardh D. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort. Clin Gastroenterol Hepatol. 2016 Mar;14(3):403-409.e3. PubMed PMID: 26453955
• Snyder J, Butzner JD, DeFelice AR, Fasano A, Guandalini S, Liu E, Newton KP. Evidence-Informed Expert Recommendations for the Management of Celiac Disease in Children. Pediatrics. 2016 Sep;138(3). PubMed PMID: 27565547
• Kemppainen KM, Vehik K, Lynch KF, Larsson HE, Canepa RJ, Simell V, Koletzko S, Liu E, Simell OG, Toppari J, Ziegler AG, Rewers MJ, Lernmark Å, Hagopian WA, She JX, Akolkar B, Schatz DA, Atkinson MA, Blaser MJ, Krischer JP, Hyöty H, Agardh D, Triplett EW. Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity. JAMA Pediatr. 2017 Dec 1;171(12):1217-1225. PubMed PMID: 29052687
• Hagopian W, Lee HS, Liu E, Rewers M, She JX, Ziegler AG, Lernmark Å, Toppari J, Rich SS, Krischer JP, Erlich H, Akolkar B, Agardh D. Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity. Pediatrics. 2017 Nov;140(5). PubMed PMID: 29018046
• Koletzko S, Lee HS, Beyerlein A, Aronsson CA, Hummel M, Liu E, Simell V, Kurppa K, Lernmark Å, Hagopian W, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Krischer J, Agardh D. Caesarean Section on The Risk of Celiac Disease in the Offspring: The Teddy Study. J Pediatr Gastroenterol Nutr. 2017 Jul 27. [Epub ahead of print] PubMed PMID: 28753178
• Mårild K, Størdal K, Bulik CM, Rewers M, Ekbom A, Liu E, Ludvigsson JF. Celiac Disease and Anorexia Nervosa: A Nationwide Study. Pediatrics. 2017 May;139(5). PubMed PMID: 28557761
• Smith LB, Lynch KF, Kurppa K, Koletzko S, Krischer J, Liu E, Johnson SB, Agardh D. Psychological Manifestations of Celiac Disease Autoimmunity in Young Children. Pediatrics. 2017 Mar;139(3). PubMed PMID: 28219962
• Simmons JH, Foster NC, Riddlesworth TD, DuBose SN, Redondo MJ, Liu E, Freemark M. Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry. Pediatr Diabetes. 2018 Jun;19(4):741-748. PubMed PMID: 29271067
• Kemppainen KM, Vehik K, Lynch KF, Larsson HE, Canepa RJ, Simell V, Koletzko S, Liu E, Simell OG, Toppari J, Ziegler AG, Rewers MJ, Lernmark Å, Hagopian WA, She JX, Akolkar B, Schatz DA, Atkinson MA, Blaser MJ, Krischer JP, Hyöty H, Agardh D, Triplett EW. Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity. JAMA Pediatr. 2017 Dec 1;171(12):1217-1225. PubMed PMID: 29052687
• Hagopian W, Lee HS, Liu E, Rewers M, She JX, Ziegler AG, Lernmark Å, Toppari J, Rich SS, Krischer JP, Erlich H, Akolkar B, Agardh D. Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity. Pediatrics. 2017 Nov;140(5). PubMed PMID: 29018046
• Mehta P, Pan Z, Riley MD, Liu E. Adherence to a Gluten-free Diet: Assessment by Dietician Interview and Serology. J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):e67-e70. PubMed PMID: 28806297
• Koletzko S, Lee HS, Beyerlein A, Aronsson CA, Hummel M, Liu E, Simell V, Kurppa K, Lernmark Å, Hagopian W, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Krischer J, Agardh D. Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study. J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):417-424. PubMed PMID: 28753178
• Andrén Aronsson C, Lee HS, Hård Af Segerstad EM, Uusitalo U, Yang J, Koletzko S, Liu E, Kurppa K, Bingley PJ, Toppari J, Ziegler AG, She JX, Hagopian WA, Rewers M, Akolkar B, Krischer JP, Virtanen SM, Norris JM, Agardh D. Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk. JAMA. 2019 Aug 13;322(6):514-523. PubMed PMID: 31408136
• Uusitalo U, Andren Aronsson C, Liu X, Kurppa K, Yang J, Liu E, Skidmore J, Winkler C, Rewers MJ, Hagopian WA, She JX, Toppari J, Ziegler AG, Akolkar B, Norris JM, Virtanen SM, Krischer JP, Agardh D. Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk. Nutrients. 2019 Aug 2;11(8). PubMed PMID: 31382440
• Mårild K, Dong F, Lund-Blix NA, Seifert J, Barón AE, Waugh KC, Taki I, Størdal K, Tapia G, Stene LC, Johnson RK, Liu E, Rewers MJ, Norris JM. Gluten Intake and Risk of Celiac Disease: Long-Term Follow-up of an At-Risk Birth Cohort. Am J Gastroenterol. 2019 Aug;114(8):1307-1314. PubMed PMID: 31082869
• Liu E, Dong F, Barón AE, Taki I, Norris JM, Frohnert BI, Hoffenberg EJ, Rewers M. High Incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes. Gastroenterology. 2017 May;152(6):1329-1336.e1. PubMed PMID: 28188747
• Kemppainen KM, Lynch KF, Liu E, Lönnrot M, Simell V, Briese T, Koletzko S, Hagopian W, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Lernmark Å, Hyöty H, Triplett EW, Agardh D. Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life. Clin Gastroenterol Hepatol. 2017 May;15(5):694-702.e5. PubMed PMID: 27840181
• Lindfors K, Lin J, Lee HS, Hyöty H, Nykter M, Kurppa K, Liu E, Koletzko S, Rewers M, Hagopian W, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Petrosino JF, Lloyd RE, Agardh D. Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study. Gut. 2020 Aug;69(8):1416-1422. PubMed PMID: 31744911
• Andrén Aronsson C, Lee HS, Hård Af Segerstad EM, Uusitalo U, Yang J, Koletzko S, Liu E, Kurppa K, Bingley PJ, Toppari J, Ziegler AG, She JX, Hagopian WA, Rewers M, Akolkar B, Krischer JP, Virtanen SM, Norris JM, Agardh D. Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk. JAMA. 2019 Aug 13;322(6):514-523. PubMed PMID: 31408136
• Uusitalo U, Andren Aronsson C, Liu X, Kurppa K, Yang J, Liu E, Skidmore J, Winkler C, Rewers MJ, Hagopian WA, She JX, Toppari J, Ziegler AG, Akolkar B, Norris JM, Virtanen SM, Krischer JP, Agardh D. Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk. Nutrients. 2019 Aug 2;11(8). PubMed PMID: 31382440
• Stahl MG, Dong F, Lamb MM, Waugh KC, Taki I, Størdal K, Stene LC, Rewers MJ, Liu E, Norris JM, Mårild K. Childhood growth prior to screen-detected celiac disease: prospective follow-up of an at-risk birth cohort. Scand J Gastroenterol. 2020 Nov;55(11):1284-1290. PubMed PMID: 32941083
• Mehta P, Stahl MG, Germone MM, Nagle S, Guigli R, Thomas J, Shull M, Liu E. Telehealth and Nutrition Support During the COVID-19 Pandemic. J Acad Nutr Diet. 2020 Dec;120(12):1953-1957. PubMed PMID: 32792328
• Stahl MG, Geno Rasmussen C, Dong F, Waugh K, Norris JM, Baxter J, Yu L, Steck AK, Frohnert BI, Liu E, Rewers MJ. Mass Screening for Celiac Disease: The Autoimmunity Screening for Kids Study. Am J Gastroenterol. 2020 Jul 22. [Epub ahead of print] PubMed PMID: 32701732
• Stahl MG, Mehta P, Liu E, Shull MH. Pushing the Gluten-free Envelope: First Steps Towards Evidence-based Gluten-free Diet Recommendations. J Pediatr Gastroenterol Nutr. 2020 Mar;70(3):275-276. PubMed PMID: 31899732
• Liu E, Wolter-Warmerdam K, Marmolejo J, Daniels D, Prince G, Hickey F. Routine Screening for Celiac Disease in Children With Down Syndrome Improves Case Finding. J Pediatr Gastroenterol Nutr. 2020 Aug;71(2):252-256. PubMed PMID: 32304557
• Stahl MG, Geno Rasmussen C, Dong F, Waugh K, Norris JM, Baxter J, Yu L, Steck AK, Frohnert BI, Liu E, Rewers MJ. Mass Screening for Celiac Disease: The Autoimmunity Screening for Kids Study. Am J Gastroenterol. 2021 Jan 1;116(1):180-187. PubMed PMID: 32701732
• Mehta P, Pan Z, Riley MD, Liu E. Adherence to a Gluten-Free Diet: Assessment by Dietician Interview and Serology. J Pediatr Gastroenterol Nutr. 2017 Aug 11. [Epub ahead of print] PubMed PMID: 28806297
• Simmons JH, Foster NC, Riddlesworth TD, DuBose SN, Redondo MJ, Liu E, Freemark M. Sex- and age-dependent effects of celiac disease on growth and weight gain in children with type 1 diabetes: Analysis of the type 1 diabetes Exchange Clinic Registry. Pediatr Diabetes. 2017 Dec 22. [Epub ahead of print] PubMed PMID: 29271067
• Germone MG, Ariefdjohan M, Stahl M, Shull M, Mehta P, Nagle S, Tarbell S and Liu E. Family ties: the impact of celiac disease on children and caregivers. Qual Life Res. 2022 Jan 4.
• Germone M, Phu T, Slosky C, Pan Z, Jones A, Stahl M, Mehta P, Shull M, Ariefdjohan M, Liu E. Anxiety and Depression in Pediatric Patients with Celiac Disease: A Large Cross-Sectional Study. J Pediatr Gastroenterol Nutr. 2022 Aug 1;75(2):181-185.
• Cheung T, de Zoeten EF, Hoffenberg EJ, Liu E, Pan Z, Walker T, Stahl M.J. Characteristics of Children With Inflammatory Bowel Disease and Coexisting Celiac Disease Seropositivity. Pediatr Gastroenterol Nutr. 2022 Dec 1;75(6):737-742.
• Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study. PLOS ONE in press.
• Shuler B, Liu E, Stahl MG. Population level screening for celiac disease: is now the time?. Curr Opin Gastroenterol. 2023 Nov 1;39(6):455-462. PubMed PMID: 37678180
• Mehta P, Li Q, Stahl M, Uusitalo U, Lindfors K, Butterworth MD, Kurppa K, Virtanen S, Koletzko S, Aronsson C, Hagopian WA, Rewers MJ, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Agardh D, Liu E. Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study. PLoS One. 2023;18(2):e0275123. PubMed PMID: 36730234
• Stahl M, Li Q, Lynch K, Koletzko S, Mehta P, Gragert L, Norris JM, Andrén Aronsson C, Lindfors K, Kurppa K, Ilonen J, Krischer J, Alkolkar B, Ziegler AG, Toppari J, Rewers MJ, Agardh D, Hagopian W, Liu E. Incidence of Pediatric Celiac Disease Varies by Region. Am J Gastroenterol. 2023 Mar 1;118(3):539-545. PubMed PMID: 36219178
• Hård Af Segerstad EM, Mramba LK, Liu X, Uusitalo U, Yang J, Norris J, Virtanen SM, Liu E, Kurppa K, Koletzko S, Ziegler AG, Toppari J, Rewers M, Akolkar B, Krischer JP, Aronsson CA, Agardh D. Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk. Am J Clin Nutr. 2023 Dec;118(6):1099-1105. PubMed PMID: 38044022
• Corrado MM, Jia X, Geno Rasmussen C, Pyle L, Yu L, Liu E, Stahl M, Rewers MJ. Previous SARS-CoV-2 Infection Is Not Associated With Increased Celiac Disease Autoimmunity in Children and Adolescents. Am J Gastroenterol. 2023 Sep 1;118(9):1698-1700. PubMed PMID: 37159249
• Alexander E, Stahl M, Weaver A, Devara J, Fahey LM, Singh A, Leonard MM, Weisbrod V, Shull M, Silvester J, Kramer Z, Kerzner B, Liu E, Absah I. The Spectrum of Duodenal Histologic Findings in Patients With Trisomy 21: A Multicenter Study. J Pediatr Gastroenterol Nutr. 2023 Aug 1;77(2):184-190. PubMed PMID: 37184455
• Incidence of Pediatric Celiac Disease Varies by Region. American Journal of Gastroenterology. In press.

Professional Memberships

• North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN), Member
• Children’s Digestive Health and Nutrition Foundation (CDHNF), Member
• Pediatric Academic Societies (PAS), Member
• North American Society for the Study of Celiac Disease (NASSCD), Member

Practice Locations

• Children's Hospital Colorado
• University of Colorado Hospital

Specialty Information

• Pediatric Gastroenterology, Board Certification (2003, 2013)

• Digestive System - Gastroenterology (Stomach, Bowel, General GI Problems)
• Child and Teen Health
• Digestive System